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Atkinson, John David. "Regulation of the E. coli Replicative Helicase DnaB by the Helicase Loader DnaC". Thesis, University of Glasgow, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485809.
Pełny tekst źródłaArribas, Bosacoma Raquel. "Resolució de l'estructura tridimensional de l'helicasa hexamètrica DnaB". Doctoral thesis, Universitat de Girona, 2009. http://hdl.handle.net/10803/7639.
Pełny tekst źródłaDnaB is the main replicative helicase in bacteria. An atomic model for the DnaB from Aquifex aeolicus at a 4.5 Å resolution is presented. It´s a ring-shaped homohexamer (100 Å width and 80 Å hight) with two simmetry layers, a C3 N-terminal layer and an almost C6 C-terminal one. The diameter of the central channel is 25 Å along both layers, being the main diference with the previously solved structures, which were 25 Å smaller along the N-terminal layer. This is due to one of the previous interacting surphaces being lost in the current structure, thus enabling a higher felxibility of the subdomain involved. Only ssDNA can pass trhough the ring, while both ssDNA and dsDNA could in the previous structures. So, the present structure is closer to the functional conformation, while the previous ones would correspond to the inactive form or the conformation that is only able to translocate along dsDNA.
Weigelt, Johan. "Development of new NMR techniques and the structure of the N-terminal domain of Escherichia coli DnaB helicase /". Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3414-2.
Pełny tekst źródłaMcRobbie, Anne-Marie M. "Splitting, joining and cutting : mechanistic studies of enzymes that manipulate DNA". Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/951.
Pełny tekst źródłaSong, Daqing. "Homologous Strand Exchange and DNA Helicase Activities in Plant Mitochondria". Diss., CLICK HERE for online access, 2005. http://contentdm.lib.byu.edu/ETD/image/etd931.pdf.
Pełny tekst źródłaLeah, Labib. "Helicase Purification for DNA Sequencing". Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31341.
Pełny tekst źródłaRudolf, Jana. "Characterisation of XPD from Sulfolobus acidocaldarius : an iron-sulphur cluster containing DNA repair helicase". Thesis, St Andrews, 2007. http://hdl.handle.net/10023/159.
Pełny tekst źródłaKorhonen, Jenny. "Functional and structural characterization of the human mitochondrial helicase /". Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-102-2/.
Pełny tekst źródłaJohnson, Vinu. "Structural and Biophysical Studies of Single-Stranded DNA Binding Proteins and dnaB Helicases, Proteins Involved in DNA Replication and Repair". University of Toledo / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1198939056.
Pełny tekst źródłaTasleem, Arsala. "Helicase Attachment to Carbon Nanotubes for DNA Sensor". Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37392.
Pełny tekst źródłaDillingham, Mark Simon. "Biochemical studies on DNA helicases". Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312245.
Pełny tekst źródłaMankouri, Hocine William. "DNA helicases and yeast ageing". Thesis, University of Liverpool, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367550.
Pełny tekst źródłaTognetti, Silvia. "Helicase activation mechanisms during initiation of DNA replication". Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/40925.
Pełny tekst źródłaHarrison, Ryan M. "Molecular biophysics of strong DNA bending and the RecQ DNA helicase". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:f02fc167-b705-4275-a413-21d13b5d94c3.
Pełny tekst źródłaOzdemir, Ahmet Yunus. "BIOCHEMICAL STUDIES OF DNA POLYMERASE THETA". Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/560412.
Pełny tekst źródłaPh.D.
POLQ is a unique multifunctional replication and repair gene that encodes a multidomain protein with a N-terminal superfamily 2 helicase and a C-terminal A-family polymerase. Although the function of the polymerase domain has been investigated, little is understood regarding the helicase domain. Multiple studies have reported that polymerase θ-helicase (Polθ-helicase) is unable to unwind DNA. However, it exhibits ATPase activity that is stimulated by single-stranded DNA, which presents a biochemical conundrum. In contrast to previous reports, we demonstrate that Polθ-helicase (residues 1– 894) efficiently unwinds DNA with 3'–5' polarity, including DNA with 3' or 5' overhangs, blunt- ended DNA, and replication forks. Polθ-helicase also efficiently unwinds RNA-DNA hybrids and exhibits a preference for unwinding the lagging strand at replication forks, similar to related HELQ helicase. Finally, we find that Polθ-helicase can facilitate strand displacement synthesis by Polθ-polymerase, suggesting a plausible function for the helicase domain. Taken together, these findings indicate nucleic acid unwinding as a relevant activity for Pol theta in replication repair. DNA polymerase theta is a unique polymerase-helicase fusion protein that promotes microhomology-mediated end-joining of DNA double-strand breaks. How full-length human DNA polymerase theta performs microhomology-mediated end-joining and is regulated by the helicase and disordered central domain remains unknown. We find that the helicase upregulates DNA polymerase theta microhomology-mediated end-joining activity in an ATPase-independent manner. Using single-particle microscopy, we find that DNA polymerase theta forms large multimeric complexes that promote DNA accumulation and end-joining. We further find that the disordered central domain regulates DNA polymerase theta multimerization and governs its DNA substrate requirements for end-joining. In summary, these studies identify major regulatory functions for the helicase and central domains in DNA end-joining and the structural organization of DNA polymerase theta.
Temple University--Theses
Cavanagh, David R. "DNA helicase II and exonuclease V of Escherichia coli". Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293560.
Pełny tekst źródłaHuber, Michael D. "Structure-function analysis and substrate specific inhibition of RecQ helicases /". Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/9253.
Pełny tekst źródłaMcFarlane-Majeed, Laura. "A functional characterisation of the DNA helicase Ch1R1 in DNA replication and repair". Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5919/.
Pełny tekst źródłaSedman, Tiina. "Characterization of the yeast Saccharomyces Cerevisiae mitochondrial DNA helicase hmi1 /". Online version, 2005. http://dspace.utlib.ee/dspace/bitstream/10062/1332/5/sedman.pdf.
Pełny tekst źródłaLevin, Mikhail Konstantinovich. "DNA UNWINDING MECHANISM OF THE HELICASE FROM HEPATITIS C VIRUS". The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1017851412.
Pełny tekst źródłaJordan, Christian. "Helicase-SSB Interactions In Recombination-Dependent DNA Repair and Replication". ScholarWorks @ UVM, 2014. http://scholarworks.uvm.edu/graddis/270.
Pełny tekst źródłaManhi, Hoida Ismail Abdel-Aziz. "Bloom DNA helicase facilitates homologous recombination between diverged homologous sequences". Kyoto University, 2011. http://hdl.handle.net/2433/142044.
Pełny tekst źródłaZhong, Yichen. "Mechanistic Studies of Human Chromodomain-Helicase-DNA-Binding Protein 4". Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23473.
Pełny tekst źródłaTokonzaba, Etienne. "Molecular mechanism of SV40 large tumor antigen helicase /". Connect to abstract via ProQuest. Full text is not available online, 2007.
Znajdź pełny tekst źródłaTypescript. Includes bibliographical references (leaves 82-92; 128-134). Online version available via ProQuest Digital Dissertations.
Ali, Yusuf I. "Design, synthesis and characterisation of tool inhibitors targeting BLM helicase". Thesis, University of Sussex, 2018. http://sro.sussex.ac.uk/id/eprint/80487/.
Pełny tekst źródłaRichards, Jodi Dominique. "Helicases and DNA dependent ATPases of Sulfolobus solfataricus /". St Andrews, 2008. http://hdl.handle.net/10023/474.
Pełny tekst źródłaRichards, Jodi D. "Helicases and DNA dependent ATPases of Sulfolobus solfataricus". Thesis, University of St Andrews, 2008. http://hdl.handle.net/10023/474.
Pełny tekst źródłaOchem, Alexander. "Properties of two DNA helicases of human cells". Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299015.
Pełny tekst źródłaSyed, Salahuddin. "Nonreplicative DNA Helicases Involved in Maintaining Genome Stability". Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6408.
Pełny tekst źródłaChilton, Scott S. "A mutational analysis of the Bacillus subtilis competence helicase ComFA". Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11560.
Pełny tekst źródłaMarkham, Jonathan Edward. "Biotin-containing enzymes from Brassica napus and Arabidopsis thaliana". Thesis, Durham University, 1996. http://etheses.dur.ac.uk/1648/.
Pełny tekst źródłaCassidy, Sarah Anne. "Stabilisation of DNA triple helices". Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242535.
Pełny tekst źródłaNovoa, Carolina. "RecQ-like helicase SGS1 counteracts DNA : RNA hybrid induced genome instability". Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/60964.
Pełny tekst źródłaScience, Faculty of
Graduate
ROSSI, SILVIA EMMA. "INTERPLAY BETWEEN THE DNA HELICASES PIF1 AND RRM3, THE NUCLEASE DNA2 AND THE CHECKPOINT PATHWAYS IN THE MAINTENANCE OF THE DNA REPLICATION FORK INTEGRITY". Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/471797.
Pełny tekst źródłaKlaue, Daniel. "DNA Unwinding by Helicases Investigated on the Single Molecule Level". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-97596.
Pełny tekst źródłaJeder Organismus ist bestrebt, die genetischen Informationen intakt zu halten, die in seiner DNA gespeichert sind. Dies wird durch präzise gesteuerte zelluläre Prozesse wie DNA-Replikation, -Reparatur und -Rekombination verwirklicht. Ein wesentlicher Schritt ist dabei das Entwinden von DNA-Doppelsträngen zu Einzelsträngen. Diese chemische Reaktion wird von Helikasen durch die Hydrolyse von Nukleosidtriphosphaten katalysiert. Obwohl bei allen Helikasen bestimmte Aminosäuresequenzen hoch konserviert sind, können sie sich in Eigenschaften wie Struktur, Funktion oder DNA Substratspezifität stark unterscheiden. Gegenstand der vorliegenden Arbeit ist es, die Entwindungsmechanismen von drei verschieden Helikasen aus zwei unterschiedlichen Organismen zu untersuchen, die sich in ihrer Struktur sowie ihrer Funktion unterscheiden. Es handelt sich dabei um die replikative, hexamerische Helikase Large Tumor-Antigen (T-Antigen) vom Simian-Virus 40 und die DNA-Reparatur-Helikasen RecQ2 und RecQ3 der Pflanze Arabidopsis thaliana. Um DNA-Entwindung in Echtzeit zu untersuchen, wird eine biophysikalische Einzelmolekültechnik, die \"Magnetische Pinzette\", verwendet. Mit dieser Technik kann man ein DNA-Molekül, das an ein magnetisches Partikel gebunden ist, strecken und gleichzeitig dessen Gesamtlänge messen. Mit speziellen DNA-Konstrukten kann man so bestimmte Eigenschaften der Helikasen bei der DNA-Entwindung, wie z.B. Geschwindigkeit, Länge der entwundenen DNA (Prozessivität) oder den Einfluß von Kraft, ermitteln. Es wird gezeigt, dass T-Antigen eine der langsamsten und prozessivsten Helikasen ist. Im Gegensatz zu prokaryotischen Helikasen ist die Entwindungsgeschwindigkeit von T-Antigen kaum kraftabhängig. Aktuelle Modelle sagen dieses Verhalten nicht vorraus, weshalb ein alternatives Modell entwickelt wird. Die untersuchten RecQ-Helikasen zeigen ein Entwindungsverhalten bei dem permanent kurze Abschnitte von DNA entwunden und wieder zusammengeführt werden. Dieses Verhalten wird hier zum ersten Mal unter dem Einfluß externer Kräfte gemessen. Es wird gezeigt, dass die permanente Entwindung auf die Fähigkeit beider Helikasen, von einem einzelen DNA-Strang auf den anderen zu wechseln, zurückzuführen ist. Obwohl RecQ2 und RecQ3 beide das Verhalten des permanenten Entwindens aufzeigen, unterscheiden sie sich stark in anderen Eigenschaften. Der gravierendste Unterschied ist, dass RecQ2 wie eine klassische Helikase die DNA entwindet, während RecQ3 eher bestrebt ist, die DNA-Einzelstränge wieder zusammenzuführen. Die unterschiedlichen Eigenschaften könnten die verschieden Aufgaben beider Helikasen während DNA-Reparaturprozessen widerspiegeln. Weiterhin werden die experimentellen Methoden optimiert, um möglichst hohe Auflösungen der Daten zu erreichen. Dazu zählen der Aufbau einer verbesserten und stabileren \"Magnetischen Pinzette\" mit sub-nanometer Auflösung und die Entwicklung neuer Methoden, um DNA Konstrukte herzustellen. Außerdem wird die Torsions\\-steifigkeit von magnetischen Partikeln in externen magnetischen Feldern untersucht. Dabei finden sich Auswahlkriterien für DNA-gebundene magnetische Partikel, durch die eine hohe Auflösung erreicht wird
Bailey, Scott. "Structural investigations of the Bacillus subtilis SPP1 phage G39P helicase inhibitor loading protein". Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246919.
Pełny tekst źródłaLangland, Gregory Todd. "Interaction Between the BLM Helicase and the DNA Mismatch Repair Protein, MLH1". University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1052316756.
Pełny tekst źródłaBrüning, Jan-Gert. "Underpinning replication of protein-bound DNA by the accessory replicative helicase Rep". Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/8220/.
Pełny tekst źródłaChou, Ta-Chung. "The molecular role of the Saccharomyces cerevisiae DNA helicase Srs2 during meiosis". Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/8446/.
Pełny tekst źródłaLee, Myung Soo. "Studies on the DNA helicase activities of the Escherichia coli primosome : involved in DNA replication fork movement /". Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=744115351&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Pełny tekst źródłaBernard, Emmanuelle Alexa. "Cloning and characterisation of the Xenopus laevis bloom's protein". Thesis, University of Sussex, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367351.
Pełny tekst źródłaPaes, Hazel Margaret. "The kinetics of DNA triple helices". Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242691.
Pełny tekst źródłaFletcher, Ryan James. "Structural and biochemical studies of mini-chromosomal maintenance proteins /". Connect to full text via ProQuest. IP filtered, 2005.
Znajdź pełny tekst źródłaTypescript. Includes bibliographical references (leaves 84-97). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
Meistermann, Isabelle. "DNA major groove recognition by supramolecular helicates". Thesis, University of Warwick, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246782.
Pełny tekst źródłaYu, Jei-Hwa. "MAPKs regulate nuclear import of human papillomavirus type 11 replicative helicase E1". Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008d/yu.pdf.
Pełny tekst źródłaZecevic, Alma. "Role of WRN helicase in repair of chromate induced DNA damage : final version". View abstract/electronic edition; access limited to Brown University users, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3318377.
Pełny tekst źródłaBurrage, Joseph. "Analysis of the function of LSH in DNA damage repair". Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/9416.
Pełny tekst źródłaHunt, Laura. "Investigating the role of the Srs2 DNA helicase during meiosis in S. cerevisiae". Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19942/.
Pełny tekst źródłaLitman, Rachel. "Characterization of the BACH1 Helicase in the DNA Damage Response Pathway: a Dissertation". eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/329.
Pełny tekst źródłaLeon, Ronald P. "Structural and functional analysis of MCM helicases in eukaryotic DNA replication /". Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.
Znajdź pełny tekst źródłaTypescript. Includes bibliographical references (leaves 90-98). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;