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Rozprawy doktorskie na temat „Division of Veterinary Medicine”

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Data publikacji: 28 lipca 2024

Data aktualizacji: 30 lipca 2024

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1

Lincoln, Anne E. "A supply-side approach to occupational feminization veterinary medicine in the United States, 1976-1995 /". Online access for everyone, 2004. http://www.dissertations.wsu.edu/Dissertations/Spring2004/A%5FLincoln%5F050404.pdf.

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2

Wyse, Cathy. "Exhaled breath microanalysis in veterinary medicine". Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433584.

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3

Bidaisee, Satesh. "Females in veterinary medicine : why the choice?" Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7621/.

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Veterinary Medicine as a profession has undergone a change from a male-oriented one, to being predominantly female. The increase in female students is a reflection of the increasing interest in veterinary medicine by females. This study focused on reasons for the specific choice of veterinary medical education among female veterinary students. A life history approach was applied in order to explore the lives of six female veterinary students from St. George’s University, School of Veterinary Medicine in Grenada. This methodology involved using interviews to collect personal accounts of students’ life experiences that provided data about the reasons for the choice of female students to pursue veterinary medical education. The theoretical framework that served as the base for this thesis was grounded theory. Interviews were transcribed, exerted to concept identification, data reduction, and thematic representations for analysis. The study revealed that life experiences as well as socio-cultural realities surrounding the lives of the students were crucial in understanding the influences and reasons for their choice of veterinary medicine. A Life Stages Theory emerged from the use of grounded theory approach to data analysis which identified personal, financial and academic needs as primary to create interest in veterinary medicine. The experiential enquiry into the students’ lives also recognized pet ownership, exposure to knowledge of veterinary medicine as well as positive perceptions of veterinarians and veterinary medical practice as reasons for the choice of veterinary medicine. The final choice of veterinary medicine by females was found to be based on their personal interests, their ability to overcome financial and academic barriers and receive opportunities of alternative academic pathways. The new insights created on reasons for the choice of veterinary medicine can be applied to student career advisement and review of applicants for admission into veterinary schools.

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4

Villamil, José Armando Henry Carolyn J. "Use of the veterinary medical database to update the veterinary oncology literature". Diss., Columbia, Mo. : University of Missouri-Columbia, 2009. http://hdl.handle.net/10355/6741.

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The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on March 25, 2010). Vita. Thesis advisor: Carolyn J. Henry. "December 2009" Includes bibliographical references.

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5

Jeyaretnam, Joseph S. "Occupational hazards and radiation safety in veterinary practice including zoo veterinary practice in Australia". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2003. https://ro.ecu.edu.au/theses/1306.

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This thesis contains reviews and research on the occupational hazards of zoo veterinary practitioners in Australia. Although occupational hazards have long been recognised in the veterinary profession, little information is available on the number and magnitude of injuries to veterinarians in Australia, the United Kingdom or the United States. Apart from anecdotal accounts and some limited data, most of the available information is on occupational zoonoses, generally well recognized by veterinarians. Other occupational hazards to which veterinarians are exposed have received scant attention. The veterinary practitioner in a zoo environment has to treat a range of captive wild species which are much more unpredictable and dangerous than domesticated animals. A comprehensive study on occupational hazards sustained by veterinarians in zoological gardens has not been undertaken in Australia. Only one study had been undertaken in the US amongst zoo veterinarians, while comprehensive may not be able to be transposed to zoos in Australia as the species held in Australian zoos differ from those in the US. Personal communication with some senior veterinarians in the zoological gardens in Australia, have elicited further information on the prevalence of occupational hazards sustained by the zoo and wildlife park veterinarians. The prevalence of physical hazards including radiation, chemical and biological hazards reported by veterinary practitioners and the author's own experience as a veterinary practitioner, chairman of the safety committee, member of the animal ethics committee and manager, research In the zoological gardens in Perth, Western Australia have demonstrated a need for a comprehensive study on occupational hazards prevalent among zoo veterinarians. To investigate the occupational hazards including radiological hazards amongst zoo veterinarians in Australia, a self-administered 14-page comprehensive questionnaire comprising 58 questions was mailed to 27 practising zoo veterinarians in Australia. The questionnaire focused on physical injuries, chemical exposures, allergic and irritant reactions, biological exposures, radiological hazards including problems encountered with x-ray machines, use of protective gear and ancillary equipment for radiography, personnel involved in x-ray procedures and in restraining animals, compliance with the Australian National Health and Medical Research Council (NHMRC) Code of Practice (1982), Radiation Safety Regulations (1988) and National Standard for Limiting Occupational Exposure to Ionising Radiation (1995) The result of the study revealed that 60% of the participants sustained physical injuries such as crushes, bites and scratches inflicted by a range of species with some Injuries requiring medical treatment. Also, 50% of the participants suffered from back injuries while 15% reported fractures, kicks, bites necessitating hospitalization. Ninety percent of the participants sustained needlestick injuries ranging from one to 16+ times. Other significant findings include: necropsy injuries, animal allergies, formaldehyde exposure, musculoskeletal Injuries and zoonotic infections. The survey also identified that veterinary practitioners and their staff were exposed to radiation by not complying with the National Health and Medical Research Council (NHMRC) Australian Code of Practice for the Safe Use of Ionising Radiation (1982) which has been framed to minimize exposure to ionising radiation. The majority of the veterinarians in the study group indicated that radiation exposure Is a major occupational hazard to the veterinary profession. Subsequent to the review and research, discussions were held with few senior zoo veterinarians, the Registrar of the Veterinary Surgeons Board and a number of practising senior veterinarians In Australia to collect information on occupational hazards. Additional information was obtained on occupational injuries sustained by the zoo veterinarians through formal discussions with the Director and the two senior veterinarians In the zoological gardens in Sri Lanka. The discussions with the veterinary practitioners in government and private practice revealed that veterinarians experienced a range of occupational hazards including exposure to rabies. Discussions with the dean and the professor of the animal science department focused on the nature of injuries and preventive strategies. In order to obtain information on occupational hazards in the health care industry, the professor of anatomy of the faculty of medicine and a senior surgeon in Sri Lanka were interviewed. This study identified that the zoo veterinarians are routinely exposed to a wide range of occupational hazards. The literature review among veterinary practitioners In US, UK, Australia and Canada have also identified numerous occupational hazards sustained by the veterinarians. The discussions held in Sri Lanka with the professionals in veterinary and health care industry showed that occupational injuries have been common amongst them and they do not have appropriate preventive guidelines in place. This thesis has incorporated recommendations in the form of preventive strategies for minimizing occupational hazards among veterinary practitioners both in zoological gardens and veterinary practices In Australia and in the developed and developing countries.

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6

Morse, Evan M. "Minority Student Perceptions of the Veterinary Profession: Factors Influencing Choices of Health Careers". Cleveland, Ohio : Cleveland State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=csu1232135567.

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Thesis (M.A.)--Cleveland State University, 2008.
Abstract. Title from PDF t.p. (viewed on Apr. 14, 2009). Includes bibliographical references (p. 82-86) and appendices. Available online via the OhioLINK ETD Center. Also available in print.

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7

Lambertini, Carlotta <1987&gt. "New applications of alpha2-agonists in veterinary medicine". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8427/2/tesi%20CLambertini.pdf.

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Alpha2-agonists are a class of drugs widely used in veterinary anaesthesia; moreover by means of their action on adrenoceptors that are widespread distributed in several tissues, they can be beneficial for different clinical applications. The aim of this work was to describe new applications of alpha2-agonists in veterinary medicine. In cats, high dose medetomidine is administered to perform semen collection by urethral catheterization. We have investigated the haemodynamic effects of high dose medetomidine (0.13 mg kg-1) administered to healthy male cats. Haemodynamic evaluations were performed before and after medetomidine administration and consisted of: clinical examination, blood pressure evaluation and transthoracic echocardiography. Significant hemodynamic alterations were observed, even if they were similar to that provided by lower dosages. The cats recovered without clinical alterations. Despite their cardiovascular side effects, low doses of alpha2-agonists can be beneficial for the maintenance of a good cardiovascular stability for specific conditions. In humans, dexmedetomidine helps in maintaining a good hemodynamic stability if administered for pheochromocytoma ablation. We have described the administration of dexmedetomidine for the anesthetic management of two dogs with a suspicion of pheochromocytoma undergoing adrenalectomy. Dogs received dexmedetomidine intramuscularly (0.001 mg kg-1) and dexmedetomidine and remifentanil were administered (0.0005 mg kg-1h-1 and 0.0003 mg kg-1min-1, respectively) throughout the surgery. In this study dexmedetomidine infusion together with remifentanil provided satisfactory intraoperative anesthetic and hemodynamic control in two dogs with a suspicion of pheochromocytoma. In patients undergoing craniotomy, dexmedetomidine, increasing the cerebral vascular resistance, prevents alteration of the cerebral blood flow. We have described the administration of dexmedetomidine in five Macaca fascicularis undergoing craniotomy for physiologic research. The Macaca were sedated with ketamine (8 mg kg-1) and dexmedetomidine (0.02 mg kg-1) intramuscularly. Dexmedetomidine was administered by infusion (0.012 mg kg-1h-1) throughout the procedure and provided adequate analgesia and a stable hemodynamic control in healthy Macaca.
I farmaci alfa2-agonisti sono largamente utilizzati in anestesia veterinaria; inoltre, grazie alla loro azione sui recettori alpha-adrenergici, distribuiti in diversi tessuti, sono utilizzati per diverse applicazioni cliniche. L'obiettivo del presente studio è stato quello di descrivere nuove applicazioni degli alfa2-agonisti in medicina veterinaria. Nel gatto, la medetomidina somministrata ad alte dosi consente la raccolta del seme mediante cateterismo uretrale. Abbiamo valutato gli effetti emodinamici della medetomidina somministrata al dosaggio di 0.13 mg kg-1 in gatti sani. Le valutazione emodinamiche sono state eseguite prima e dopo la somministrazione di medetomidina mediante visita clinica, misurazione della pressione sistemica ed ecocardiografia transtoracica. Dallo studio sono state evidenziate alterazioni emodinamiche significative, ma simili a quelle riportate dopo somministrazione di dosi più basse. I farmaci alpha2-agonisti, nonostante le alterazioni cardiovascolari che inducono, se somministrati a basse dosi, possono contribuire al mantenimento di una buona stabilità emodinamica in condizioni cliniche specifiche. Nell'uomo, la somministrazione di dexmedetomidina in pazienti sottoposti a rimozione di un feocromocitoma contribuisce a mantenere parametri emodinamici intraoperatori stabili. Abbiamo descritto la somministrazione perioperatoria di dexmedetomidina in due cani sottoposti a surrenalectomia per un sospetto di feocromocitoma. Entrambi hanno ricevuto dexmedetomidina intramuscolo (0.001 mg kg-1) e dexmedetomidina e remifentanil sono stati somministrati in infusione (0.0005 mg kg-1h-1 e 0.0003 mg kg-1min-1, rispettivamente) per tutta la chirurgia. Il protocollo utilizzata ha permesso di mantenere un piano anestesiologico e condizioni emodinamiche stabili in due cani con sospetto di feocromocitoma. Nei pazienti sottoposti a neurochirurgia, la dexmedetomidina previene alterazioni significative del flusso cerebrale. Abbiamo descritto la somministrazione di dexmedetomidina in esemplari di Macaca fascicularis sottoposti a craniotomia. I macachi sono stati sedati con ketamina e dexmedetomidina. La dexmedetomidina è stata somministrata in infusione continua (0.012 mg kg-1h-1) per tutta la procedura e ha permesso di mantenere un'analgesia adeguata e parametri emodinamici stabili in macachi sani.

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8

Hammill, Bess Catherine. "Veterinary anatomy laboratory impact study". Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/11048.

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Thesis (M.S.)--West Virginia University, 2010.
Title from document title page. Document formatted into pages; contains vii, 56 p. : col. ill. Vita. Includes abstract. Includes bibliographical references (p. 35-36).

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9

Byington, Tori C. "Post-DVM educational intentions among third-year veterinary medical students : a hierarchical analysis of mentoring, gender, and organizational context". Online access for everyone, 2006. http://www.dissertations.wsu.edu/Dissertations/Spring2006/t%5Fbyington%5F042606.pdf.

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10

Folk, Lillian C. "A study of the Veterinary Medical Database /". Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1421133.

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Rathinasabapathy, G., i L. Rajendran. "Web-based Digital Resources for Small Animal Medicine Professionals". e-Science World, 2009. http://hdl.handle.net/10150/299578.

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The Internet which is also known as ‘Information Superhighway’, ‘Global Information Infrastructure’, ‘Cyberspace’, ‘Hyperspace’ etc., connects millions of computers in a web and makes almost immediate communication possible, irrespective of the location of its users. The Internet provides huge resources that are useful for veterinary and animal science professionals and the amount of accessible veterinary medicine information is increasing rapidly. Ideally, this could provide a formidable opportunity for Veterinarians to exchange and process veterinary medicine information with colleagues around the world from their desktop. Though the Internet offers virtually unlimited amount of information related to small animal medicine and surgery and provides a number of tools to access, it is useful in at least three aspects related to veterinary medicine and surgery viz., communication, education and research. This paper attempts to profile such important digital knowledge resources useful for small animal veterinary medicine professionals.

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12

Hammond, Jennifer. "Training for uncertainty in veterinary education". Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/9000/.

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This thesis addresses the question of how veterinary students learn to cope with uncertainty in professional practice. There is currently a lack of clarity in discussion of what constitutes effective coping with uncertainty in veterinary practice and indeed how this might be taught or assessed as part of the veterinary education process. This is despite wide recognition that managing uncertainty is central to practice in the health professions, reflected in the fact that the ability to cope with uncertainty is considered a “day one competency” for veterinary surgeons. This research adopted both extensive and intensive perspectives to address the central research question. Orienting concepts were developed form the literature on workplace learning, approaches to clinical uncertainty and individual differences in tolerance of uncertainty and ambiguity. The extensive perspective used a survey study to describe tolerance of ambiguity among veterinary students at a UK veterinary school. On average, ambiguity tolerance did not change during the classroom based part of veterinary training. Individual trajectories were often more erratic and some students moved between the highest and lowest categories during the course of training. Previous education and status as a mature student were both associated with greater tolerance of ambiguity, suggesting that educational and life experiences can produce changes in this disposition. The intensive perspective comprised a qualitative case study, using clinical case discussion recordings and semi-structured interviews to develop an understanding of the mechanisms which influence learning to cope with uncertainty in the context of an international elective placement. Using the language of situated learning theory, learning to cope with uncertainty was described as legitimate peripheral participation in the uncertainty work of a community of practice. Uncertainty work is a novel concept used to describe navigating ambiguity, complexity and risk in professional practice . Using this theoretical framework to draw together findings from both intensive and extensive perspectives suggested the central role of gaining access to uncertainty work in professional learning. Generative mechanisms have been proposed to explain the empirical findings. Access to uncertainty work was negotiated between students and staff in the context of clinical and educational practice. Trust was central to gaining access to uncertainty work, and this was reflected in increasing clinical responsibility. Ambiguity tolerance was described in this context as a disposition of individuals which can influence their engagement with and access to uncertainty work. Through an exploration of the significance of these mechanisms in the context of Veterinary education, implications for curriculum and policy have been highlighted. Although the use of measures of ambiguity tolerance in selection are considered problematic, there can be clear scope to support students in accessing uncertainty work and to highlight encounters with uncertainty work as integral to the professional role, providing opportunities to promote personal and professional development through reflective practice.

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13

Gardiner, Andrew A. "Small animal practice in British veterinary medicine 1920-1956". Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532236.

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14

PIGOLI, CLAUDIO. "MYCOBACTERIAL DISEASES IN VETERINARY MEDICINE: MORPHOPATHOLOGY AND MYCOBACTERIAL PHENOTYPES". Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/843675.

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Mycobacteria are an ancient bacterial taxon that has, over time, had a profound impact on mankind and domesticated animals. Mycobacteria are, in fact, responsible for significant human and animal diseases whose severe economic and public health repercussions make them still highly topical today. The first topic of research in this Thesis is a widely characterized phenomenon in the context of human tuberculosis, but one which has, to date, been little considered in animal tubercular infections, namely mycobacterial dormancy. As bovine tuberculosis (bTB) is undoubtedly the most significant of the animal tubercular infections, these aspects have been investigated precisely in the context of this pathology. In particular, this study aimed to verify the intralesional existence of non-acid-fast (non-AF) mycobacteria phenotypes that in human medicine have been associated to the phenomenon of mycobacterial dormancy. Another important objective of this study was to develop a histological method capable of detecting in the same section the mycobacterial cells by combining AF stains and techniques capable of highlighting the mycobacteria regardless of their AF features. In this retrospective study, 250 bovine lymph nodes (LNs) in which Mycobacterium bovis (Mb) has been identified by the diagnostic algorithm routinely applied by the Italian National Reference Center for bTB, were randomly enrolled. Ziehl-Neelsen (ZN) stained sections were evaluated for each sample. Only LNs with at least one granuloma containing more than 20 ZN-positive bacilli were selected, and the corresponding formalin-fixed and paraffin-embedded blocks were retrieved. For each block, a 4-µm thick section was obtained and, after reducing the autofluorescence through a photobleaching protocol and unmasking the Mb antigens with enzymatic digestion, the sections were submitted to a protocol combining Auramine O stain and an indirect immunofluorescence assay targeting Mb antigens; a DAPI-containing mounting medium was used. Processed slides were viewed with a Leica DM6 B upright microscope, and the obtained images were elaborated with a deconvolution algorithm. Of the 250 enrolled LNs, 24 contained at least one granuloma with more than 20 ZN-positive bacilli, and in all of them, AF and non-AF bacilli were identified. In all (24/24) selected LNs, the non-AF bacillary load resulted greater than the AF one, especially in the central parts of the granuloma; non-AF bacilli were also identified within the cytoplasm of multinucleated giant macrophages (MGMs). This study revealed for the first-time non-AF Mb phenotypes within bovine lymph nodal granulomatous lesions. It also demonstrated that a widely studied pathology such as bTB still poses new issues regarding pathogenesis and host-pathogen interaction and suggested that bTB can be considered an effective animal model for studying mycobacterial dormancy. The second study carried out was also focused on a tubercular infection but, in this latter case, both the mycobacterial species involved and the affected host were different. Indeed, in the second study, wild boar (WB) M. microti (Mm) infection, whose epidemiological and pathogenic dynamics are still largely unknown, was enquired into. Specifically, the natural WB Mm infection was investigated by evaluating the granulomatous lesions' histological features and Mm microbiological isolation. For this purpose, 103 WB retropharyngeal and submandibular LNs in which Mm was identified by gyrB restriction fragment length polymorphism PCR were retrospectively selected and histologically assessed. For each sample, Hematoxylin-eosin and ZN-stained slides were evaluated. Considered histological variables were the number of granulomas, size and maturational stage of granulomas, number of MGMs, and AF bacilli per granuloma. Furthermore, Mm microbiological results were also considered. Investigated parameters were statistically analyzed. Mm microbiological isolation was negatively influenced by granulomas maturation and positively affected by AF bacilli's presence within the section. Granuloma maturation was positively influenced by granuloma size and negatively affected by the number of granulomas in the section and the number of MGMs within the granuloma. The obtained results indicate that granulomas' maturation ensured an efficient containment of Mm infection in the WB, making the intraspecific transmission of the disease an unlikely event. Finally, an outbreak of paratuberculosis in a group of scimitar-horned oryxes (SHOs) kept in a zoological park, gave us the chance to describe various aspects of this disease in an endangered animal species subject to an international conservation and reintroduction plan encompassing several countries. In particular, after the death of six of the 10 SHOs, serial investigations of dead and alive animals were performed. Necropsy, carried out on five out of six animals, identified intestinal thickening and mesenteric lymphadenomegaly in one of the animals. Histopathology (5/6) revealed lepromatous (2/5) and tuberculoid (2/5) intestinal forms or lack of lesions (1/5). ZN and immunohistochemistry stains identified two multibacillary, two paucibacillary forms, and one negative case. M. avium subsp. paratuberculosis (Map) was identified by quantitative PCR (qPCR) in tissue samples in five out of five SHOs and was microbiologically isolated from two of the three animals whose fresh tissue samples were available. Fecal samples were collected in four of the six dead animals: all four resulted positive to qPCR and Map was isolated in three. ELISA identified Map-specific antibodies in three of the five dead animals whose serum was available. qPCR identified Map in the freshly deposited feces of two out of the four alive animals. From the feces of these two animals, Map was microbiologically isolated in one case. All isolates were classified as Map type C and profiled as INMV2 and MVS27 by molecular analysis. Genomic analysis of a field isolate revealed clusterization with a European clade but was more similar to Italian than East European isolates. Our findings highlight again that paratuberculosis should always be considered in zoological parks where endangered species are hosted. Infection can be subclinical, and multiple combined testing techniques may be necessary. The studies included in this Thesis made the examination of certain aspects of significant animal mycobacterial diseases possible, and the results obtained demonstrate that a multidisciplinary approach is the best option when studying infectious diseases, and this is especially true in case of infections deserving to be managed in a One Health perspective.

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Streit, Timothy Michael. "KINETIC STUDY OF THE SIDE-DOOR MUTANTS OF THE MODEL CARBOXYLESTERASE PNB CE". MSSTATE, 2007. http://sun.library.msstate.edu/ETD-db/theses/available/etd-06212007-134428/.

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Carboxylesterases (CEs) metabolize a wide range of endogenous compounds and xenobiotics containing ester bonds. Crystal structures of mammalian CEs indicate a ?side door? located adjacent to the catalytic gorge that may act as an alternative pore for the trafficking of substrates and products. This study investigated the role of the ?gate? residue of the side door during para-Nitrobenzyl esterase (pnb CE)-catalyzed hydrolysis of esters. Purified recombinant pnb CE proteins were examined for their hydrolytic activity toward several esters. Mutation of the gate residue altered the kinetic parameters of pnb CE toward these substrates, demonstrated by increased Km values and decreased Vmax values. Site-specific mutations of the ?gate? residue also affected the sensitivity of the enzyme toward inhibiting organophosphate compounds. A distinct possibility is that the side door mutants affect substrate hydrolysis by increasing the steric hindrance and/or electrostatic repulsion between the substrate and the active site catalytic residues.

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16

Wan, Xiufeng. "AN AMINOPEPTIDASE ACTING AS A POTENTIAL FACTOR IN HOST ADAPTATION OF MYCOPLASMA GALLINARUM". MSSTATE, 2002. http://sun.library.msstate.edu/ETD-db/theses/available/etd-06242002-150613/.

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Unlike most other host-specific mycoplasmas, Mycoplasma gallinarum exists as a commensal with a host range including most poultry as well as some mammals. This property of M. gallinarum may reflect unique mechanisms for its colonization and persistence in hosts. Whereas M. gallinarum shows leucine and arginine aminopeptidase activity, the genes encoding the enzymes had not been cloned and characterized. We identified an aminopeptidase gene (APN) by oligonucleotide hybridization to a genomic library of M. gallinarum in lambda ZAPII bacteriophage. Nucleotide sequence analysis of overlapping phage clones identified a 1,362 bp open reading frame (ORF) encoding a putative leucine aminopeptidase gene. Database searches indicate that this ORF has 68% nucleotide identity and 51% amino acid identity with the M. salivarium leucine aminopeptidase gene. The active sites of the leucine aminopeptidases in other eukaryotes and prokaryotes were conserved in the cloned aminopeptidase gene. Northern-blot hybridization analysis showed that this ORF is expressed as a 1.5 kb transcript. Southern-blot hybridization analysis demonstrated this gene was present as a single copy in M. gallinarum. Characterization of the leucine aminopeptidase demonstrated that it is a metallo-aminopeptidase (EC 3.4.11.1) and is located in the cytoplasm with a weak interaction with the cell membrane. The subcellular location was further confirmed by immunoblotting with polyclonal anti-recombinant APN serum and M. gallinarum Triton-114 partitions. Immunoblotting results with sera from three chickens experimentally infected with M. gallinarum showed that there were very few proteins in M. gallinarum exposed to the host immune responses and that leucine aminopeptidase was not able to stimulate production of specific humoral antibody. Our results suggest that this leucine aminopeptidase play a role in nutrition supply for the host adaptation of M. gallinarum and that the enzyme was not strongly immunogenic.

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Horstman, Christopher Larry. "BIOMECHANICAL AND METABOLIC CHANGES WITHIN RABBIT ARTICULAR CARTILAGE FOLLOWING TREATMENT WITH RADIOFREQUENCY ENERGY". MSSTATE, 2005. http://sun.library.msstate.edu/ETD-db/theses/available/etd-11112005-081324/.

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The effects caused to articular cartilage by the remote use of arthroscopically-delivered RF energy to soft tissues in the joint are unknown. This investigation reported the short and long-term effects of bRF and mRF energy on the biomechanical properties and metabolic activity of articular cartilage. In addition, the effect of Cosequin® therapy was addressed. Thirty New Zealand white rabbits were randomly assigned to one of two treatment groups (Group 1 - placebo; Group 2 - Cosequin®). Histopathology, cell viability, GAG synthesis, and mechanical function of the articular cartilage were compared between groups. Data were analyzed using a mixed model ANOVA (p=0.05). Immediate chondrocyte death was created by both RF devices. This damage was noted to be superficial and did not lead to the progressive deterioration of the extracellular matrix or mechanical function of the articular cartilage. Cosequin® therapy was unable to demonstrate significant differences compared to the control group.

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18

Hawkins, Stacey M. "Opportunities and occupations in animal and veterinary sciences based on the current careers of West Virginia University alumni". Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2671.

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Thesis (M.S.)--West Virginia University, 2002.
Title from document title page. Document formatted into pages; contains viii, 57 p. Vita. Includes abstract. Includes bibliographical references (p. 44).

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19

Ortega, Meyer Bruno de Jesus. "A proposed framework for harmonization of the veterinary medicine curriculum in Latin America". [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-2606.

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20

Reyes-Illg, Gwendolen. "Respect for Patient Autonomy in Veterinary Medicine| A Relational Approach". Thesis, Colorado State University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10640397.

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This thesis considers the prospects for including respect for patient autonomy as a value in veterinary medical ethics. Chapter One considers why philosophers have traditionally denied autonomy to animals and why this is problematic; I also present contemporary accounts of animal ethics that recognize animals’ capacity for and exercise of autonomy (or something similar, such as agency) as morally important. In Chapter Two, I review veterinary medical ethics today, finding that respect for patient autonomy is undiscussed or rejected outright as irrelevant. Extrapolating mainstream medical ethics’ account of autonomy to veterinary medicine upholds this conclusion, as it would count all patients as “never-competent” and consider determining their autonomous choices impossible; thus welfare alone would be relevant. Chapter Three begins, in Part I, by describing the ways we routinely override patient autonomy in veterinary practice, both in terms of which interventions are selected and how care is delivered. I also show that some trends in the field suggest a nascent, implicit respect for patient autonomy. Part II of Chapter Three presents feminist criticisms of the mainstream approach to patient autonomy. I argue that the relational approach to autonomy advocated by such critics can be meaningfully applied in the veterinary realm. I advance an approach that conceives respect for patient autonomy in diachronic and dialogic terms, taking the patient as the foremost locus of respect. In Chapter Four, I turn to issues of practical implementation, such as interpreting what constitutes an animal’s values and concerns, and assessing the effect of positive reinforcement training on autonomy. The Conclusion offers areas for future research while refuting the objection that a simpler, expanded welfare-based approach would yield the same substantive recommendations as my account.

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21

Barachetti, L. "AMNIOTIC MEMBRANE TRANSPLANTATION FOR OCULAR SURFACE RECONSTRUCTION IN VETERINARY MEDICINE". Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/150198.

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The fetal membrane is composed by the chorion, allantois and amnion. The AM is the inner layer. It consists of a single layer of ectodermally derived cuboidal to columnar cells, which form the epithelium, a basement membrane that connects with the chorion by a layer of mesenchyme which contains large amounts of collagen (stroma). Amniotic basement membrane and stroma contain cytokines, proteoglycans, collagen type I, III, IV, V and VII, laminin and fibronectin. Different interesting properties of the AM have been described. Amniotic basement membrane, by serving as a “transplanted basement membrane”, acts as a new healthy substrate that facilitates migration of epithelial cells, reinforces adhesion of basal epithelial cells, promotes epithelial differentiation, and prevents epithelial apoptosis. Additionally AM produces various growth factors, inhibits protease activity, has anti-inflammatory, anti-angiogenic and antifibrotic effects. The non-immunogenicity of the AM was believed to be another important property. AM transplantation (AMT) has been widely described in human ophthalmology for the reconstruction of corneal and/or conjunctival surface in different diseases, such as: ocular surface neoplasia, pterygium, chemical and thermal burns, cicatrizing conjunctivitis, symblepharon release, bleb leakage, filtering surgery, persistent epithelial defects, non healing stromal ulcers, deep stromal ulcers and descemetoceles, neurotrophic keratopathy, limbal stem cells deficiency, bullous keratopathy, infectious keratitis, Stevens Johnson syndrome, melting ulcers, scleral melt and band keratopathy. In veterinary ophthalmology AMT has been described for the treatment of ocular surface neoplasia, bullous keratopaty, melting ulcers, symblepharon, immun-mediated keratitis and in conjunction with penetrating keratoplasty. The objective of our study was to evaluate the effects of amniotic membrane transplantation for reconstruction of the ocular surface in different diseases in dogs, cats and horses. We evaluated the cosmesis and visual function. In our case series we performed AMT with the inlay technique in 3 dogs (3 eyes), 6 cats (7 eyes) and 11 horses (11 eyes). The diseases treated were: 7 feline corneal sequestra, 4 corneal melting (1 dog and 3 horses), 2 dermoids (2 dogs), 4 keratomycosis (4 horses), 2 corneo-conjunctival squamous cell carcinoma (2 horses), 1 immunomediate keratitis (1 horse) and 1 corneal edema (1 horse). In our results the objective was obtained: we had successful outcome in 17 of the 21 eyes treated; no ocular pain was detected in the immediately postoperative period, the AM epithelialized quickly and, after the fibrovascular invasion of the AM, all the corneas obtained a good transparency and no recurrence was detected in our follow-up periods.

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22

Done, Stanley Herbert. "Climate, aerial pollution and pneumonia in a pig finishing house". Thesis, Royal Veterinary College (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309249.

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McCarthy, Helen Elizabeth. "A case-control study to investigate risk factors for equine grass sickness with a particular reference to the role of Clostridium botulinum". Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250565.

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24

Luke, Cliff J. "In vitro characterisation of the protease, VP4 in infectious bursal disease virus". Thesis, University of Surrey, 1998. http://epubs.surrey.ac.uk/843479/.

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Infectious bursal disease virus (IBDV) is a member of the birnavirus family and is the causative agent of infectious bursal disease (IBD). The virus has a bisegmented dsRNA genome; the larger of these 2 segments is segment A and has 3 open reading frames (ORFs). One of these ORFs encodes a polyprotein that is processed to 3 polypeptides VPX, VP3, and VP4. VP4 has been demonstrated to be responsible for the cleavage of the polyprotein in an autocatalytic co-translational manner. The VP4 protein has not yet been characterised and has no homology with any other known protease except a limited homology with the Lon protease in bacteria. Several active sites are proposed; with the spacing of type I serine proteases, with spacing of type II serine proteases and with spacing of the beta-lactamase family of proteases. The cleavage sites have been proposed by molecular weight determination as being 2 dibasic residues at either end of VP4. Here I describe the expression of the full length polyprotein in a coupled transcription/translation system and in E. coli. Deletion mutagenesis of the VP4 revealed that VP4 is required for correct processing of the processing of VP3 and the processing of VPX to VP2. However, the processing of VP3 is only completely abolished when a deletion into VP3 passed the A-x-AAS cleavage site. Deletion mutagenesis of the N terminus of VP3 in the polyprotein showed that the cleavage sites of VP4 as being A-x-AAS sequences. Site directed mutagenesis studies within VP4 revealed several important residues for the correct processing, the most important of these being the S652. Of the residues mutated here, there does not seem to be a "classical" catalytic triad for this protease.

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25

Collins, Alison Jane. "Ontogeny of lactase-phlorizin hydrolase in the pig small intestine". Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388687.

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26

Wilkes, Margaret. "Clinical and morphological investigations into inner ear disease in the dog with special reference to deafness and vestibular deficit in the Doberman". Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385502.

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Otter, Arthur. "A study of the neuropathogenesis of listerial encephalitis". Thesis, University of Cambridge, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359880.

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Da, Costa Ana P. C. "Neurohumoral control of maternal behaviour in sheep". Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360634.

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Horsburgh, Brian Colin. "Molecular studies of canine coronvirus". Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240988.

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Littlewood, Janet Denise. "Factor VIII - phospholipid mixtures and factor VIII inhibitors : studies in haemophilic dogs". Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278069.

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31

McKerrell, Rosemary. "Labrador retriever myopathy : clinical and pathological investigation". Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306555.

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Baxi, Mohit K. "Molecular studies of equine herpesvirus 1 latency". Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390272.

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Awan, Aftab ur Rehman. "Studies on the pathogenesis of equine herpesvirus 1 and host responses to the infection in a mouse model". Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387109.

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34

Yu, Qingzhong. "Molecular analysis of the fusion (F), matrix (M) and M2 protein genes of turkey rhinotracheits pneumovirus and the role of F in immunity". Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241241.

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35

Anderson, Denise Veronica. "Construction and characterization of mouse X calf heterohybridomas and their use for bovine monoclonal antibody production". Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328564.

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36

Silva, D. D. N. de. "Central control of breathing in animals under anaesthesia". Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238393.

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37

Maldonado, Francisco A. Galindo. "The relationship between behaviour and occurence of lameness in dairy cows". Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363473.

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38

Stanley, Karen Nicola. "Seasonal varation of the thermophilic campylobacters in farm animals and the farm environment". Thesis, Lancaster University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337461.

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39

Watson, Patricia Roxburgh. "The role of toxins and invasion in the pathogenesis of bovine Salmonellosis". Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338348.

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Grognono-Thomas, Rosemary. "The role of (S)-layer proteins in ovine Campylobacter fetus infections". Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312325.

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41

Woodbury, Emma Louise. "Studies on the persistence of single and multiple foot-and-mouth disease virus serotypes in the bovine". Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244041.

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42

Ezaz, Zere. "Studies in Menz sheep". Thesis, Bangor University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276196.

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43

Saluja, Patricia Gail. "Vetting the vets : the regulation of the veterinary profession in the UK". Thesis, University of Aberdeen, 2010. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=158484.

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This thesis investigates the regulation of the veterinary profession in the UK. In the UK this profession is regulated by the Royal College of Veterinary Surgeons (RCVS) under the Veterinary Surgeons Act 1966 (VSA 1966). Since that date there have occurred vast changes in veterinary medicine and science and the delivery of veterinary services, legal developments in other areas, including professional regulatory law, and societal changes in attitudes towards animals and expectations of the professions. This research was undertaken in order to determine whether the regulatory system for the veterinary profession in the UK is well designed to achieve the aims appropriate to the present-day profession, and to propose reforms where these are indicated. The system was evaluated by applying a set of benchmark criteria used by the National Health Service Ombudsman for England whose jurisdiction encompasses clinical as well as administrative matters. The study shows that the current system is well suited to functions such as regulating and monitoring veterinary education and rule-making for the control of animal diseases and zoonoses. However, the overall conclusion is that the VSA 1966 is outdated and should be replaced by new legislation. Arguments are made in favour of the following key reforms: separation of regulatory role from Royal College functions; changes in the composition of the regulatory body; introduction of the regulation of paraprofessionals and veterinary practices; plus a range of changes across the disciplinary system involving revision of the grounds and sanctions for disciplinary action, clarification of the identity of the regulator, reforms in the investigation of complaints, disciplinary hearings, appeals and the position of the complainant in the disciplinary process. Whilst some improvements could be made under the current regime, the view remains that new legislation is needed. Although it appears that the RCVS is in favour of this, the necessary political will seems to be lacking on the part of government.

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Guthrie, Wendy. "Keeping clients in line : a grounded theory explaining how veterinary surgeons control their clients". Thesis, University of Strathclyde, 2000. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=21125.

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This thesis explains how veterinary surgeons keep their clients in line through a melange of fact and fiction. Originating from the intimate study of veterinary interactions, it represents theory systematically grounded in data. Veterinarians employ mystification processes to manipulate clients' awareness. Vets engage in coaching clients to suit their own agendas. These activities may be benign or opportunistic. Cultivating strategies are also explained whereby vets seek apparently friendly relationships with clients. This disguises the instrumental nature of these interactions. The research indicates that keeping people in line is a robust process evident in diverse contexts. It has obvious commercial significance and is likely to be of relevance to veterinarians, their clients, marketers, researchers and potentially to those wishing to control others in diverse contexts.

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45

Barwick, Ian M. "Drug recovery from medicated animal feeds". Thesis, Loughborough University, 1993. https://dspace.lboro.ac.uk/2134/10360.

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Investigations into the poor recovery of sulphadimidine from medicated animal feeds have shown that irreversible drug-feed binding, and not drug degradation, is responsible for the poor recoveries. The experimental work involved the novel use of C-sulphadimidine in analytical studies and in autoradiography of C-sulphadimidine-bound feed. The latter showed that the drug was not bound preferentially to specific feed constituents but was widely distributed on nearly all the feed particles. Further work on sulphadimidine recovery from feeds demonstrated an inverse relationship between drug recovery and feed moisture content. The role of moisture in the binding mechanism was then considered, and experiments conducted on the adsorption of moisture by feeds showed that the rate controlling mechanism was diffusion. A hypothesis is presented in which sulphadimidine is partially dissolved by the moisture in the feed and the resulting solution then diffuses into the internal regions of the feed particles via pores and cracks in the constituent particles. The deep penetration of the drug into the feed prevents the drug from being recovered by the extraction solution. Experimental evidence was found to support this hypothesis. Experimental work also investigated the causes of poor recoveries of sulphadiazine, trimethoprim and dinitolmide.

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46

Kennedy, Seamus. "Pathology of experimentally induced nutritional degenerative myopathy in ruminant cattle". Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484303.

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McIlroy, Samuel George. "The epidemiology of bovine tuberculosis". Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484278.

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Prayitno, Slamet Budi. "Studies of bacteria causing prawn disease in Indonesia with special emphasis on luminous bacterial disease". Thesis, Bangor University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.483433.

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49

Rennie, Louise Frances. "The persistence of African swine fever virus in the argasid tick Ornithodoros moubata". Thesis, University of Hertfordshire, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245350.

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African swine fever virus (ASFV) usually causes a fatal haemorrhagic disease in domestic pigs. However ASFV has no apparent adverse effects on its vertebrate reservoir hosts, warthogs (Phacochoerus aethiopicus) and bushpigs (Potamochoerus porcus). The virus is maintained in the wild by a campestral cycle between wild members of the family Suidae, especially warthogs, and the argasid ticks which inhabit their burrows. Infection of Ornithodoros moubata with the VIC T90/1 or LIV 13/33 isolate of ASFV did not have an adverse effect on the oviposition rates of infected female ticks. Hatching rates of eggs laid by infected females were also unaffected. In addition infection with ASFV did not cause a significant reduction in the feeding and moulting rates of first nymphal stage ticks from infected females. The feeding rates of adult ticks infected with either of the two isolates of virus were also unaffected. However, infected adult ticks showed an increase in mortality rates over uninfected ticks. After the second blood meal 40.0% of ticks infected with the VIC T901l isolate of ASFV died and 33.3% of ticks infected with LIV 13/33 died, whereas only 4.0% ofuninfected ticks died. Similarly after the third blood meal 93.3% of ticks infected with the VIC T901l isolate of ASFV died and 84.2% of ticks infected with LIV 13/33 died whereas 9.1% ofuninfected ticks died. ASFV is capable of being passed transovarially and transstadially within the Pirbright colony of O. moubata. Filial infection rates were highly variable between individual ticks. After the second blood meal filial infection rates ranged from 1.8% to 31.8% for ticks infected with the VIC T90/1 isolate of ASFV and from 1.2% to 35.5%. After the third blood meal filial infection rates ranged from 15.0% to 32.4% and 1.7% to 44.0% respectively. An increase in the number of blood meals increased the number of females capable of laying infected eggs and increased the filial infection rates of these females. Transstadially infected individual second nymphal stage ticks were capable of excreting up to 104 . sHADsoitick, which is sufficient to infect a pig or warthog. Dissemination and localisation of ASFV within the tick vector was monitored by using anindirect immunoperoxidase staining technique. In ticks which had been infected either orally or by direct inoculation of virus into the haemocoel, viral antigen was detected first in the sexual organs of both male and female ticks. When comparing orally infected ticks and ticks infected by direct inoculation of virus into the haemocoel, the rate at which the various organs become infected did not differ substantially. Furthermore, since infection of ticks either by inoculation of virus directly into the haemocoel (bypassing the gut) or by oral ingestion of virus, resulted in similar infection rates in the organs in the organs (31.7% and 31.0% respectively). It seems unlikely that 0. moubata possesses a gut barrier to ASFV

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Lightfoot, Ruth M. "Retinal pigment epithelial dystrophy (RPED) in the dog". Thesis, Royal Veterinary College (University of London), 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339266.

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