Gotowa bibliografia na temat „Dihydroxypyrimidines”
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Artykuły w czasopismach na temat "Dihydroxypyrimidines"
Powdrill, Megan H., Jerome Deval, Frank Narjes, Raffaele De Francesco i Matthias Götte. "Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines". Antimicrobial Agents and Chemotherapy 54, nr 3 (22.12.2009): 977–83. http://dx.doi.org/10.1128/aac.01216-09.
Pełny tekst źródłaGuo, Di-Liang, Xing-Jie Zhang, Rui-Rui Wang, Yu Zhou, Zeng Li, Jin-Yi Xu, Kai-Xian Chen, Yong-Tang Zheng i Hong Liu. "Structural modifications of 5,6-dihydroxypyrimidines with anti-HIV activity". Bioorganic & Medicinal Chemistry Letters 22, nr 23 (grudzień 2012): 7114–18. http://dx.doi.org/10.1016/j.bmcl.2012.09.070.
Pełny tekst źródłaNovais, H. M., i S. Steenken. "Reactions of oxidizing radicals with 4,6-dihydroxypyrimidines as model compounds for uracil, thymine, and cytosine". Journal of Physical Chemistry 91, nr 2 (styczeń 1987): 426–33. http://dx.doi.org/10.1021/j100286a034.
Pełny tekst źródłaTelvekar, Vikas N., i Kavitkumar N. Patel. "Pharmacophore Development and Docking Studies of the HIV-1 Integrase Inhibitors Derived from N-methylpyrimidones, Dihydroxypyrimidines, and Bicyclic Pyrimidinones". Chemical Biology & Drug Design 78, nr 1 (25.05.2011): 150–60. http://dx.doi.org/10.1111/j.1747-0285.2011.01130.x.
Pełny tekst źródłaAstrat'ev, A. A., D. V. Dashko, A. Yu Mershin, A. I. Stepanov i N. A. Urazgil'deev. "ChemInform Abstract: Some Specific Features of Acid Nitration of 2-Substituted 4,6-Dihydroxypyrimidines. Nucleophilic Cleavage of the Nitration Products." ChemInform 32, nr 51 (23.05.2010): no. http://dx.doi.org/10.1002/chin.200151070.
Pełny tekst źródłaWinterbourn, Christine C., i Rex Munday. "Concerted Action Of Reduced Glutathione And Superoxide Dismutase In Preventing Redox Cycling Of Dihydroxypyrimidines, And Their Role In Antioxidant Defence". Free Radical Research Communications 8, nr 4-6 (styczeń 1990): 287–93. http://dx.doi.org/10.3109/10715769009053361.
Pełny tekst źródłaJansa, Petr, Antonín Holý, Martin Dračínský, Viktor Kolman, Zlatko Janeba, Petra Kostecká, Eva Kmoníčková i Zdeněk Zídek. "5-Substituted 2-amino-4,6-dihydroxypyrimidines and 2-amino-4,6-dichloropyrimidines: synthesis and inhibitory effects on immune-activated nitric oxide production". Medicinal Chemistry Research 23, nr 10 (9.05.2014): 4482–90. http://dx.doi.org/10.1007/s00044-014-1018-9.
Pełny tekst źródłaShi, Daqing, Lihui Niu i Qiya Zhuang. "Clean synthesis of pyrido[2,3-d]pyrimidines in aqueous media". Journal of Chemical Research 2005, nr 10 (październik 2005): 648–50. http://dx.doi.org/10.3184/030823405774663048.
Pełny tekst źródłaKufelnicki, Aleksander, Jan Jaszczak, Urszula Kalinowska-Lis, Cecylia Wardak i Justyn Ochocki. "Complexes of Uracil (2,4-Dihydroxypyrimidine) Derivatives". Journal of Solution Chemistry 35, nr 5 (maj 2006): 739–51. http://dx.doi.org/10.1007/s10953-006-9017-1.
Pełny tekst źródłaNovais, H. M., i S. Steenken. "ESR studies of electron and hydrogen adducts of thymine and uracil and their derivatives and of 4,6-dihydroxypyrimidines in aqueous solution. Comparison with data from solid state. The protonation at carbon of the electron adducts". Journal of the American Chemical Society 108, nr 1 (styczeń 1986): 1–6. http://dx.doi.org/10.1021/ja00261a001.
Pełny tekst źródłaRozprawy doktorskie na temat "Dihydroxypyrimidines"
Garlatti, Laura. "Development of Bunyavirales endonucleases inhibitors by in situ click chemistry". Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0586.
Pełny tekst źródłaWith a worldwide repartition and limited therapeutic options Bunyavirales viruses represent a major public health issue. The replication machinery of these viruses is governed by the intricate L-protein that displays an endonuclease activity responsible for the cap-snatching mechanism that allows viral transcription. This key enzyme was identified as a promising target to develop antivirals. Its catalytic mechanism of RNA hydrolysis mediated by Mg2+ ions enables the development of diketo acid (DKA) metal-chelating inhibitors. Target-Guided-Synthesis (TGS) is a powerful method that directly involves the therapeutic target that assembles its own inhibitors in its active site like LEGOs®. Herein, we describe the use of Bunyavirales endonucleases as reaction vessels for the In Situ generation of metal-chelating inhibitors. A library of 25 N-triazolyl-DKA (NT-DKA), C-triazolyl-DKA (CT-DKA) and C-triazolyl-DHP (CT-DHP) compounds was generated with new and original synthesis pathways via click chemistry. The compounds were biophysically characterized by Microscale Thermophoresis (MST) and Differential Scanning Fluorimetry (DSF) and their inhibitory potency was evaluated in vitro and in infected cells culture. Moreover, a fluorescein-DKA ligand was synthesized for the development of a competition Fluorescence Polarization (FP) assay to determine the activity of the compounds. High-affinity ligands that demonstrated a potent efficiency in vitro and in cellula were identified. In the context of the COVID-19 pandemic, the compounds library was repositioned against SARS-CoV-2 exonuclease which opened new possibilities for the development of metal-chelating Coronavirus inhibitors
Chen, Hui-Fang, i 陳惠芳. "Self-Assembly of dihydroxypyrimidine-based Metal Complexes". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/40715693163039617195.
Pełny tekst źródła中國文化大學
應用化學研究所
95
Abstract This thesis focuses on the preparation of novel-based metal-organic frameworks based on nucleobases via self-assembly strategy and the study of the influence of pH-values and alkali hydroxide (NaOH, KOH, CsOH). We chosen two uracil-derivatives 4,6-dihydroxypyrimidine (dhp-H2) and 2,4-dihydroxypyrimidine-5-carboxylic acid (H3L1), and 2-methyl-1H-benzo[d]imidazole-5-carboxylic acid (H2L2), as potential organic ligands. At first, assembly of Ni2+, Co2+or Zn2+ ions with dhp-H2 in water or alcohol at ambient temperature led to the formation of discrete molecules, [Ni(Hdhp)2(H2O)4] (HF-1) and [Co(Hdhp)2(H2O)4] (HF-2), and three-dimensional metal-organic frameworks [Co(dhp)(H2O)]n (HF-3) and [Zn(dhp)(H2O)]n (HF-4). It is found that pH-values has a dramatically effect for the preparation of HF-1-HF-4. The aptitude range of pH-values for HF-1 and HF-2 is from 9 to 10, while for HF-3 and HF-4, the values range from 11 to12. When Tb3+and Eu3+ is reacted with H3L in water or alcohol at ambient temperature, compound {K2[Tb(H2L1)4(OH)].2H2O}n (HF-5), {K2[Eu(H2L1)4(OH)].2H2O}n (HF-6) and [Tb(H2L1)(HL1)(H2O)4].3H2O (HF-7) were obtained. In this system, the influence of pH-value to the formation of HF-5-HF-7 was also observed. The aptitude range of pH-values for HF-5-HF-7 is from 9 to 10. Finally, the self-assembly reaction of Cu2+ and 2-methyl-1H-benzo[d]imidazole-5-carboxylic acid in water or alcohol at ambient temperature gave compound {[Cu(HL2)2(H2O)].1/2 H2O }n (HF-8) , which adopts a one-dimensional chain-like architecture. The solid-state structures of the products were characterized by single-crystal X-ray diffraction analyses and their properties were examined by TGA and PXRD, etc.
Chen, Han-Yin, i 陳函听. "Self-assembly, Structures, and Properties of Coordination Compounds Based on Dihydroxypyrimidine". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/psfr2d.
Pełny tekst źródła國立臺北科技大學
化學工程研究所
101
This thesis focuses on the preparation of based metal–organic frameworks based on nucleobases via a self-assembly strategy. Two uracil-derivatives, 4,6-dihydroxypyrimidine (H2dhp) and 2,4-dihydroxypyrimidine-5-carboxylic acid (H3dhpca), were selected for use as potential organic ligands. The assembly of CaII, NiII ions with 4,6-dihydroxypyrimidine (H2dhp) in water or alcohol at ambient temperature led to the formation of the discrete molecule [Ni(Hdhp)2(H2O)4] (1) and a 2D metal–organic frameworks {[Ca(Hdhp)2(H2O2)]•THF}n (2). When MnII, MgII and ZnII were reacted with 2,4-dihydroxypyrimidine-5-carboxylic acid (H3dhpca) in water or alcohol at ambient temperature, the discrete compounds [Mn(H2dhpca)2(H2O)2] (3), {[Mg(H2-dhpca)2(H2O)2]•2H2O} (4) , and {[K2(H2O)6][Zn(H2dhpca)2(H2O)2]} (5) were produced. The solid-state structures of the products were characterized by single-crystal X-ray diffraction analyses and their thermal stabilities were examined by TGA method.
Części książek na temat "Dihydroxypyrimidines"
Ishikawa, T. "From 5-Amino-2,6-dihydroxypyrimidine-4-carboxylic Acid". W Six-Membered Hetarenes with Two Identical Heteroatoms, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-01777.
Pełny tekst źródłaStreszczenia konferencji na temat "Dihydroxypyrimidines"
Vu, Tuan, Xuan Nguyen, Nikolai Yudin i Alexander Kushtaev. "KINETICS AND NITRATION MECHANISM OF 4,6-DIHYDROXYPYRIMIDINE AND ITS DERIVATIVES IN THE PRESENCE OF NITROUS ACID". W Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m752.aks-2019/199-205.
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