Gotowa bibliografia na temat „Dihydrolactucin”
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Artykuły w czasopismach na temat "Dihydrolactucin"
Fronczek, Chris F., Marco L. Gomez-Barrios, Nikolaus H. Fischer i Frank R. Fronczek. "11β,13-Dihydrolactucin-8-O-acetate hemihydrate". Acta Crystallographica Section E Structure Reports Online 65, nr 10 (30.09.2009): o2564—o2565. http://dx.doi.org/10.1107/s160053680903829x.
Pełny tekst źródłaShah, Shazia, Zulfiqar Ali, Abdul Malik, Ikhlas A. Khan i Sumayya Saied. "Sesquiterpene Lactones from Cichorium intybus". Zeitschrift für Naturforschung B 66, nr 7 (1.07.2011): 729–32. http://dx.doi.org/10.1515/znb-2011-0714.
Pełny tekst źródłaRuggieri, Francesca, Philippe Hance, Bruna Gioia, Alexandre Biela, Pascal Roussel, Jean-Louis Hilbert i Nicolas Willand. "A Three-Step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semisynthesis of Chicory STLs Standards". Pharmaceuticals 16, nr 5 (22.05.2023): 771. http://dx.doi.org/10.3390/ph16050771.
Pełny tekst źródłaWeng, Hui, Luanying He, Jiakun Zheng, Qing Li, Xiuping Liu i Dongliang Wang. "Low Oral Bioavailability and Partial Gut Microbiotic and Phase II Metabolism of Brussels/Witloof Chicory Sesquiterpene Lactones in Healthy Humans". Nutrients 12, nr 12 (28.11.2020): 3675. http://dx.doi.org/10.3390/nu12123675.
Pełny tekst źródłaKisiel, Wanda. "Sesquiterpene lactones from Picris pauciflora Willd." Acta Societatis Botanicorum Poloniae 64, nr 2 (2014): 159–61. http://dx.doi.org/10.5586/asbp.1995.021.
Pełny tekst źródłaHANCE, P., Y. MARTIN, J. VASSEUR, J. HILBERT i F. TROTIN. "Quantification of chicory root bitterness by an ELISA for 11β,13-dihydrolactucin". Food Chemistry 105, nr 2 (2007): 742–48. http://dx.doi.org/10.1016/j.foodchem.2007.01.029.
Pełny tekst źródłaMatos, Melanie S., José D. Anastácio, J. William Allwood, Diogo Carregosa, Daniela Marques, Julie Sungurtas, Gordon J. McDougall i in. "Assessing the Intestinal Permeability and Anti-Inflammatory Potential of Sesquiterpene Lactones from Chicory". Nutrients 12, nr 11 (19.11.2020): 3547. http://dx.doi.org/10.3390/nu12113547.
Pełny tekst źródłaIlgün, Selen, Esra Küpeli Akkol, Mert Ilhan, Derya Çiçek Polat, Ayse Baldemir Kılıç, Maksut Coşkun i Eduardo Sobarzo-Sánchez. "Sedative Effects of Latexes Obtained from Some Lactuca L. Species Growing in Turkey". Molecules 25, nr 7 (30.03.2020): 1587. http://dx.doi.org/10.3390/molecules25071587.
Pełny tekst źródłaZheleva-Dimitrova, Dimitrina, Alexandra Petrova, Gokhan Zengin, Kouadio Ibrahime Sinan, Vessela Balabanova, Olivier Joubert, Christian Zidorn, Yulian Voynikov, Rumyana Simeonova i Reneta Gevrenova. "Metabolite profiling and bioactivity of Cicerbita alpina (L.) Wallr. (Asteraceae, Cichorieae)". Plants 12, nr 5 (23.02.2023): 1009. http://dx.doi.org/10.3390/plants12051009.
Pełny tekst źródłaLang, Roman, Tatjana Lang, Andreas Dunkel, Florian Ziegler i Maik Behrens. "Overlapping activation pattern of bitter taste receptors affect sensory adaptation and food perception". Frontiers in Nutrition 9 (19.12.2022). http://dx.doi.org/10.3389/fnut.2022.1082698.
Pełny tekst źródłaRozprawy doktorskie na temat "Dihydrolactucin"
Ruggieri, Francesca. "Putting nature back into drug discovery : selection, design and synthesis of bioinspired chemical libraries for the discovery of new antibacterials". Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS013.
Pełny tekst źródłaNatural products (NPs) have declined in popularity since the introduction of synthetic small molecules several years ago. Many are the reasons behind this choice, such as difficulties in access and supply, complexities of NP chemistry and the advent of combinatorial chemistry. However, NPs offer many interesting properties compared to conventional synthetic molecules, which confer both advantages and challenges for the drug discovery process. Usually, NPs are characterized by a higher number of sp3 carbons and stereogenic centres, large scaffold diversity and structural complexity. With half of the drugs approved by the FDA since 1994 being NPs or hemisynthetic derivatives and the recent stagnation in new drug research and development, it is becoming more and more evident that NPs should be reintroduced in the drug discovery process as a source of inspiration.Therefore, many strategies are now emerging for the construction of nature-inspired chemical libraries, such as “top-down” and “bottom-up” strategies. In “bottom-up” approaches, complexity is created starting from simple building blocks. On the other hand, “top-down” approaches are assumed to make structural modifications to an already complex NP.Our presented work describes two different approaches to enrich the chemical library of our research unit with NP-derived compounds. A “top-down” semisynthetic strategy was planned to obtain derivatives of lactucin and 11β,13-dihydrolactucin, two sesquiterpene lactones extracted from chicory roots. Thirty-six ester derivatives were synthesized in three steps (classical synthesis), together with two amine derivative libraries (using parallel synthesis). All the compounds were then tested against Mycobacterium tuberculosis and some promising hits were found (MICGFP < 1.2 μM). On the other hand, a “bottom-up” strategy allowed the synthesis of two analogues of the known natural antibiotic hygromycin A. This approach started from simple commercially available building blocks and employed a dearomatization strategy in the synthetic process.Together, we explored a broader chemical space, increased the structural diversity of our chemical library and discovered new potential antibacterial hits. Moreover, this work paves the way for the discovery of new antibacterial targets