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Nordwall, Maria. "Long term complications in juvenile diabetes mellitus". Doctoral thesis, Linköping : Univ, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-6377.
Pełny tekst źródłaChoudhury, Maitrayee. "Complications in cystic fibrosis-related diabetes". Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/100648/.
Pełny tekst źródłaWu, Di. "Discovery of glyco-biomarkers for diabetes and complications in diabetes". Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/e2eee4c8-c74c-4fc6-8658-ab51ecd793de.
Pełny tekst źródłaOkafor, Eugene O. "Decreasing Acute Diabetes Complications Through Self-Management Education". ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5922.
Pełny tekst źródłaYu, Zhen. "Altered drug responses in diabetic and hypertensive-diabetic cardiomyopathy". Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29406.
Pełny tekst źródłaPharmaceutical Sciences, Faculty of
Graduate
Bunker, Richard David. "Enzymes associated with the complications of diabetes mellitus". Thesis, University of Auckland, 2010. http://hdl.handle.net/2292/7142.
Pełny tekst źródłaMorgan, Eileen. "Type 1 diabetes - epidemiology, risk factors and complications". Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678213.
Pełny tekst źródłaNaito, Masaki. "Therapeutic Impact of Leptin on Diabetes, Diabetic Complications, and Longevity in Insulin-Deficient Diabetic Mice". Kyoto University, 2012. http://hdl.handle.net/2433/157453.
Pełny tekst źródłaCross, Deborah F. "Genetic analysis of the microvascular complications of diabetes mellitus". Thesis, University of Plymouth, 2002. http://hdl.handle.net/10026.1/2316.
Pełny tekst źródłaCho, Chi Shing. "Proteomic and medicinal approaches to diabetes and its complications". HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/663.
Pełny tekst źródłaOchieng, Judith Muhonja. "Risk Perception of Developing Diabetes Complications among African American Women with Type 2 Diabetes". Diss., The University of Arizona, 2015. http://hdl.handle.net/10150/577503.
Pełny tekst źródłaLian, Jinxiao, i 連金曉. "A review of cost-effectiveness analysis of screening for diabetic complication". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42997240.
Pełny tekst źródłaVindedzis, Sally Ann. "The relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control". Thesis, Curtin University, 2008. http://hdl.handle.net/20.500.11937/248.
Pełny tekst źródłaMoffett, Henley Jasmine. "A Descriptive Analysis of Diabetic Complications and Antihypertensive Use Among Pima Indians". The University of Arizona, 2007. http://hdl.handle.net/10150/624406.
Pełny tekst źródłaObjectives: To determine the effect of antihypertensive use on renal function and other diabetic complications in adults over the age of 18 with type 2 diabetes mellitus (DM). Methods: A retrospective secondary analysis of the NIH Pima epidemiologic data included 1,828 individuals with type 2 DM were evaluated for antihypertensive use and DM complications. Statistical analysis was done using general linear model regression (GLM) or logistic regression models controlling for age, sex and DM duration. Three groups were established to evaluate antihypertensive use Group 1 those taking antihypertensives to those not taking antihypertensives, Group 2 those taking more than one (multiple) antihypertensives to those only taking one and Group 3 those taking an angiotensin converting enzyme (ACE) inhibitor to those not taking an ACE. Results: Group 1 those taking antihypertensives were significantly worse for all outcome measures than those taking no antihypertensives as evident with: renal function (ACR 43 mg/mmol versus 15.9 mg/mmol (ρ=0.0003) and albuminuria 55.8% versus 37.6% (p=0.0039), retinopathy, neuropathy and CVD. Group 2 those taking multiple antihypertensives had significantly worse renal function (ACR 69.2 mg/mmol versus 34.5 mg/mmol (p=0.0329) and albuminuria 63% versus 52% (p=0.0396)), CVD while retinopathy and neuropathy were not significantly different. Group 3 those taking ACE had significantly worse renal function (ACR 43.8 mg/mmol versus 35.2 mg/mmol (p=0.0329)) while CVD was improved and no difference was observed in retinopathy and neuropathy. Conclusions: Antihypertensive use had little impact on preventing diabetic complications. This is contrary to well- documented literature that supports the use of antihypertensives to slow disease progression and protect renal function.
McLaine, Catherine Clare. "Diabetes and oral health complications: Australian diabetes health care professionals' knowledge and scope of practice". Thesis, Curtin University, 2013. http://hdl.handle.net/20.500.11937/2373.
Pełny tekst źródłaOrr, Neil John. "Patterns of care for diabetes: risk factors for vision-threatening retinopathy". Thesis, The University of Sydney, 2005. http://hdl.handle.net/2123/1421.
Pełny tekst źródłaOrr, Neil John. "Patterns of care for diabetes: risk factors for vision-threatening retinopathy". University of Sydney, 2005. http://hdl.handle.net/2123/1421.
Pełny tekst źródłaOBJECTIVES: In Australia, diabetes causes significant morbidity and mortality. Whilst the need to prevent diabetes and its complications has been widely recognised, the capacity of health care systems - which organise diabetes care - to facilitate prevention has not been fully established. METHODS: A series of seven population-based case-control studies were used to examine the effectiveness of the Australian health care system and its capacity to manage diabetes. Six of the studies compared the patterns of care of patients who had developed advanced diabetes complications in 2000 (cases), to similar patients who remained free of the condition (controls) across Australia and for various risk groups. A secondary study investigated the role of treating GPs in the development of the outcome. RESULTS: A strong relationship between the patterns of care and the development of advanced diabetes complications was found and is described in Chapter 4. In Chapter 5, this same relationship was investigated for each Australian state and territory, and similar findings were made. The study in Chapter 6 investigated whether late diagnosis or the patterns of care was the stronger risk factor for advanced diabetes complications, finding that the greatest risk was associated with the latter. In Chapter 7 the influence of medical care during the pre-diagnosis period was explored, and a strong relationship between care obtained in this period and the development of advanced complications was found. In Chapter 8, which investigated the role of socio-economic status in the development of advanced complications, found that the risk of advanced diabetes complications was higher in low socio-economic groups. Chapter 9 investigated geographic isolation and the development of advanced diabetes complications and found that the risk of advanced complications was higher in geographically isolated populations. Finally, Chapter 10, which utilised a provider database, found that some GP characteristics were associated with the development of advanced diabetes complications in patients. CONCLUSION: A number of major risk factors for the development of advanced complications in Australia was found. These related to poorer diabetes management, later diagnosis, low socioeconomic status and geographic isolation. Strategies must be devised to promote effective diabetes management and the early diagnosis of diabetes across the Australian population.
Caracciolo, Dana Andriana. "Children's Literature and Diabetes". Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/31824.
Pełny tekst źródłaMaster of Arts
Östlund, Ingrid. "Aspects of Gestational Diabetes : Screening System, Maternal and Fetal Complications". Doctoral thesis, Uppsala University, Department of Women's and Children's Health, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3267.
Pełny tekst źródłaThe appropriateness of universal screening for gestational diabetes mellitus (GDM) has been strongly questioned, since it does not satisfy ethical principles for screening.
The aims of these studies were to determine the prevalence of GDM, expressed in terms of impaired glucose tolerance (IGT) and diabetes mellitus (DM), to evaluate different screening models using traditional anamnestic risk factors and repeated random B-glucose, to determine whether GDM increases risks for maternal complications such as preeclampsia, and to determine whether IGT during pregnancy, if left untreated, is associated with increased maternal or neonatal morbidity.
Of 4,918 pregnant non-diabetic women attending maternal health care, 73.5% agreed to have a 75 g oral glucose tolerance test (OGTT). GDM was diagnosed in 1.7%, IGT in 1.3% and DM in 0.4%. Traditional risk factor criteria were fulfilled by 15.8%. Prior GDM and a prior macrosomic infant showed the highest association with GDM. No selective or two-step universal screening model would have detected all cases of GDM. A constructed model comprising prior GDM, a prior LGA/macrosomic infant, or a cut-off random B-glucose level of 8 mmol/l as an indication for OGTT reduced the need for OGTT to 7.3% compared to the selective screening model with traditional risk factors. Such a universal two-step screening model had 100% sensitivity for DM, and 44.7% sensitivity for IGT.
The Swedish Medical Birth Register was used to evaluate GDM as risk factor for preeclampsia. GDM occurred in 0.8% and preeclampsia in 2.9% of 430,852 singleton pregnancies. There is an independent and significant association between GDM and preeclampsia. Obesity is a major confounding factor, but cannot explain the total excess risk.
In a prospective population-based case-control study 213 women with untreated IGT during pregnancy were identified. For each case, four controls were recruited from the same delivery department. The analyses confirmed that maternal and fetal morbidity were increased in the cases in terms of cesarean section rate, pre-term delivery, Erb’s palsy and admission to NICU. There was a marked, independent increase in the proportion of LGA infants (OR 7.3; 95% CI 4.1-12.7). To determine whether treatment has an effect when IGT is diagnosed during pregnancy, a randomized study is required.
Tossavainen, née Riihimaa P. (Päivi). "Markers of microvascular complications in adolescents with type 1 diabetes". Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:951426892X.
Pełny tekst źródłaLyons, Paul Anthony. "The erythrocyte polyol pathway, diabetes and its long term complications". Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46419.
Pełny tekst źródłaAjudua, Emmanuel Enuagwuna. "Profile of diabetic complications amongst diabetics attending internal medicine outpatient department and family medicine outpatient department in Dora Nginza Hospital, PE hospital complex". Thesis, Stellenbosch : University of Stellenbosch, 2015. http://hdl.handle.net/10019.1/97196.
Pełny tekst źródłaENGLISH ABSTRACT: Introduction: Diabetes is the most prevalent endocrinology problem encountered in primary care practice. If recent trends showing a dramatic increase in prevalence (believed to be a consequence of a decline in physical activity and excessive caloric intake) continue, then the condition will soon affect nearly 20 million people in the U.S a reflection of the global trend. Effective management requires care that is thoughtful and meticulous, incorporating intensive patient education. Euglycemic control, with the level of glycosylated haemoglobin (HbA1c) kept below 7.0mmol/L, has emerged as a major treatment objective because of its association with a marked reduction in the risk for micro vascular complications. The primary physician is in the unique position to provide comprehensive care to the diabetic patient. Setting: The aim of this study is to evaluate the profile of complications arising due to diabetes mellitus among adult diabetics attending internal medicine outpatient department and family medicine/primary care outpatient department in the Dora Nginza hospital, PE hospital complex. Method: The study is a descriptive retrospective study in which names of patients were collated from clinic records of both clinics, files sought at the records department covering the period between Jan 2007 and Jan 2008 inclusive. Prevalence of statistical variables was generated using frequency tables, bar graphs, cross tabulations and chi square test. Results: Hyperglycemia was the major complication which predominantly was associated with high haemoglobin A1c (HbA1c) levels. However, some hyperglycaemic cases were also found to be associated with normal HbA1c. Complications were found to be more in type 2 diabetics. Patients with hypertension, obesity, smoking and alcohol use were observed to have a higher risk of developing diabetic complications. The findings on retinopathy in this study was inconclusive in view of the fact that patients sent for fundoscopy did not return with documented results from the sister hospital PE provincial hospital. Family Medicine outpatient department overall did better in patient care compared to the Internal Medicine outpatient department. Conclusion: The challenge for the primary care physician is to design a therapeutic program that is safe practical and acceptable to the patient. The ultimate goal of therapy is the prevention of micro vascular and macro vascular complications, consequence of diabetes that makes the condition a major risk factor for cardiovascular disease, stroke, visual impairment, renal failure, impotence, peripheral neuropathy, limb loss and ultimately death. These can be averted through appropriate education of both hospital staff, patients and their care givers. The recommendations made are based on the findings of the study.
AFRIKAANSE OPSOMMING: Nie beskikbaar.
Ikombele, Botomwito. "Knowledge, attitudes and practices regarding lifestyle modifications among type 2 diabetic patients attending Mamelodi Hospital, Pretoria, South Africa". Thesis, University of Limpopo (Medunsa Campus), 2011. http://hdl.handle.net/10386/699.
Pełny tekst źródłaIntroduction The burden of type 2 diabetes mellitus continues to rise and constitutes a real threat especially in the developing world. As for most non-communicable diseases, change of behavior and adoption of healthy lifestyle habits help to prevent and slow down the increase of type 2 diabetes mellitus. Aim of the Study To establish the knowledge, attitudes and practices regarding lifestyle modifications among type 2 diabetic patients attending the diabetic clinic at Mamelodi hospital. Methods: This cross sectional study describes the knowledge, attitudes and practices regarding lifestyle modifications (KAP) among 217 type 2 diabetes mellitus patients attending Mamelodi Hospital, Pretoria, Republic of South Africa. A face-to-face interview using a structured questionnaire was carried out for data collection. Socio-demographic characteristics of the participants and anthropometric measurements were obtained and the body mass index (8MI) of participants were determined. The Knowledge, attitude and practice of participants were assessed. 2 Results: Majority of participants were female 176(81.1 %), while male were 41 (18.9%). This amounted to a female to male ratio of 4:1. Most participants were in the age group 51-60 years 93(42.9%). Majority of them had low level of education 108(49.5%) and low income 206(94.9%). Majority of participants were obese 153(71 %) with more female diabetic patients being obese 120 (78.4%) than male 33 (21.6%). 15 participants (14 females and 1 male) were morbidly obese (BMI~40kg/m2). 108 participants (49.5%) did not have a formal education. No respondent had good knowledge and 92.6% of respondents had poor knowledge of the benefits of exercise, weight loss and healthy diet. Majority of respondents (97.7%) had bad practices in relation to lifestyle modifications. Nevertheless, majority of them (84.3%) had positive attitudes toward lifestyle modifications. Significant positive correlation (r= 0.170, p=0.012) was found between the global knowledge level and attitude level alone, whereas there was no significant correlation found between the global knowledge level and practice level as well as the attitude level and practice level. Conclusion: In conclusion, despite positive attitudes of participants toward healthy lifestyle habits, the knowledge and practices regarding lifestyle modifications among type 2 diabetes mellitus patients attending Mamelodi Hospital were generally low. Nevertheless the positive attitudes of participants should be encouraged and the implementation of a lifestyle intervention program will help improve the knowledge and practices of type 2 diabetes mellitus patients attending Mamelodi Hospital for the better management and control of this current pandemic of type 2 diabetes mellitus.
Rodrigues, Brian Baltzar. "Hypertension and diabetic cardiomyopathy". Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24906.
Pełny tekst źródłaPharmaceutical Sciences, Faculty of
Graduate
Trifoglio, Emanuele. "Multi-level modeling and computational approaches to investigate long-term diabetes complications". Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3424554.
Pełny tekst źródłaIl diabete mellito rappresenta una delle patologie più diffuse nel mondo e si stima che la sua incidenza aumenterà del 50 % nell’arco di 15 anni, passando da 250 milioni a quasi 400 milioni di malati nel 2025. La patologia comporta l’insorgenza di devastanti complicanze croniche, tra cui disturbi legati al danneggiamento dei vasi sanguigni sia a livello macro-vascolare – come coronopatia, infarto, insufficienza cardiaca, angina pectoris, ictus – che micro-vascolare, con conseguente danno a carico dei reni (nefropatia) e degli occhi (retinopatia). La patologia diabetica ha un’enorme impatto sia in termini di qualità di vita dei pazienti, sia a livello economico, in quanto si stima che più del 10 % dei costi dell’assistenza sanitaria di tutta l’Europa siano imputabili alla cura del diabete. Per questo motivo, nuovi mezzi che permettano di prevenire l’insorgere e il progredire della malattia e delle sue complicanze sono assolutamente necessari. L’obiettivo del seguente lavoro di tesi è quello di proporre nuovi metodi computazionali per lo studio delle complicanze del diabete in un ambito di modellistica multi-livello. Il diabete mellito è una malattia fortemente multifattoriale, nella quale molteplici fattori di rischio di diversa natura (genetica e ambientale) concorrono a provocarne l’insorgenza e lo sviluppo. I meccanismi fisiologici che sottendono allo scatenarsi e al progredire della patologia sono ancora per la maggior parte sconosciuti. Data la natura multifattoriale del diabete, lo studio delle complicanze si presta ad essere affrontato con un approccio multi-livello. Lo schema generale di una malattia multifattoriale, come il diabete, prevede l’azione combinata di 3 elementi chiave sullo stato patologico (l’outcome) del paziente: i) il fenotipo, ovvero l’insieme di tutte le variabili metaboliche, antropometriche e ambientali caratteristiche del paziente, ii) il genotipo, ovvero la sequenza DNA del paziente, iii) il trattamento, ovvero l’insieme di interventi esterni effettuati sul paziente, come terapie ed utilizzo di farmaci. Queste 3 variabili sono interconnesse tramite interazioni e concorrono tutte insieme a determinare l’outcome del paziente. L’approccio multi-livello consente di scomporre il problema completo in sottoproblemi, focalizzando l’attenzione di volta in volta solo su un sottoinsieme di variabili e di interazioni, a seconda del livello di informazione contenuto nei dati a disposizione. Nel seguente lavoro, vengono considerati 3 principali livelli di studio delle complicanze diabetiche, e, per ognuno dei 3 ambiti, vengono proposti nuovi metodi sviluppati durante il periodo di dottorato. I 3 livelli di studio trattati sono: i) modellizzazione dell’effetto del genotipo sull’outcome, ii) modellizzazione dell’effetto combinato di fenotipo e trattamento sulla progressione dell’outcome, iii) modellizzazione dell’azione del trattamento sul fenotipo. Il primo livello di studio si propone di studiare le complicanze diabetiche da un punto di vista statico, ovvero senza considerare l’evolversi e il progredire di tali complicanze nel tempo, ed ha come obiettivo quello di identificare i principali biomarcatori genetici che consentano di predire lo stato di malattia dei pazienti, e di stratificare i pazienti in base al rischio di sviluppare o meno la malattia. I Genome Wide Association Studies (GWAS), sono studi di associazione volti a identificare gli SNPs che, da soli o in combinazioni con altri SNPs, consentono di spiegare le differenze che si osservano in un determinato outcome (a presenza o meno di una patologia) tra casi (soggetti malati) e controlli (soggetti sani) in una popolazione di studio. Diversi metodi di selezione univariata e multivariata sono presenti in letteratura per l’identificazione di marcatori genetici da studi GWAS. In questo ambito, è stato sviluppato un nuovo metodo per la selezione multivariata di biomarcatori genetici e per la classificazione di soggetti a partire da dati di SNPs di studi GWAS, basato sui classificatori di Bayes e arricchito da 3 principali componenti: i) una predizione ottenuta da un insieme di classificatori di Bayes, utilizzando una strategia basata sul bootstrap, ii) un nuovo metodo per ordinare e selezionare gli attributi selezionati da ogni classificatore, iii) una procedura, bastata sulle permutazioni, per selezionare i biomarcatori significativi, sulla base della loro utilità marginale nel processo di classificazione. Il metodo è stato validato sui dati genome-wide del Wellcome Trust Case-Control Consortium, (WTCCC) relativi a diabetici di tipo 1 e le sue performance confrontate con gli algoritmi rappresentanti lo stato dell’arte in letteratura per studi di associazione genetica, in particolare un classificatore di Bayes e un algoritmo di regressione logistica penalizzata (HyperLASSO). Il secondo livello di studio riguarda l’analisi dinamica delle complicanze, nella quale interviene anche la variabile tempo come fattore chiave. In quest’ottica, si vuole modellizzare l’insorgere e la progressione temporale delle principali complicanze legate al diabete utilizzando l’informazione fenotipica e terapeutica, con l’obiettivo di stimare la probabilità che il paziente diabetico possa o meno sviluppare una certa complicanza, ottimizzando quindi i trial clinici ed evitando esami costosi e invasivi. In letteratura, sono presenti diversi modelli delle complicanze di diabete, ma nessuno è in grado di integrare in maniera flessibile le diverse conoscenze –omiche (proteomica, metabolomica, genomica) ad un livello clinico macroscopico. I principali modelli presenti in letteratura sono infatti basati sui modelli di Markov (detti anche modelli si transizione di stato) e utilizzano l’informazione fenotipica senza la possibilità di integrare facilmente informazioni aggiuntive. In questo ambito di studio, viene proposto un nuovo modello in-silico delle complicanze cardiovascolari e renali del diabete, che propone come aspetto innovativo l’utilizzo delle reti dinamiche bayesiane (Dynamic Bayesian Networks, DBNs) per modellizzare le interazioni tra le variabili. Rispetto ai modelli di Markov, che richiedono tanti nodi quante sono le possibili combinazioni degli stati delle variabili, le DBN hanno il vantaggio di rappresentare ogni variabile tramite un singolo nodo e permettono quindi una maggiore facilità nella gestione della struttura e nell’integrazione di eventuale informazione aggiuntiva. Il modello è stato costruito utilizzando i dati del Diabetes Control and Complications Trial (DCCT), un trial clinico randomizzato condotto con lo scopo di confrontare gli effetti della terapia intensiva rispetto a quelli della terapia convenzionale sullo sviluppo delle complicanze vascolari e neurologiche a lungo termine. Il modello sviluppato, è in grado di predire la progressione delle complicanze diabetiche trattate con un’accuratezza superiore al 95% a livello di popolazione. Il modello si presta quindi ad essere utilizzato come tool di supporto nel processo di decisione terapeutica da parte dei clinici e, in quest’ottica, sta portando alla realizzazione di un’interfaccia web. La struttura flessibile del modello inoltre consentirà di integrare facilmente l’informazione genotipica, con l’obiettivo futuro di migliorare le prestazioni a livello di predizione. Il terzo ed ultimo livello di studio considerato è lo studio dell’azione di uno specifico farmaco su un particolare fenotipo, con l’obiettivo finale di sviluppare metodologie che consentano di personalizzare i farmaci, adattandoli alla specifica risposta dell’individuo. Nell’ambito specifico delle complicanze cardiovascolari del diabete, una delle terapie più diffuse è quella del trattamento con aspirina per la prevenzione di eventi avversi nei pazienti ad alto rischio. L’aspirina deve la sua azione preventiva alla capacità di inibire un enzima chiave (la prostaglandina-endoperossido sintase PTGS-1, conosciuta anche come cicloossigenasi COX-1) nella cascata che porta alla formazione di trombossano B2 (TxB2), il principale responsabile dell’aggregazione piastrinica nel sangue e della conseguente formazioni di trombi. È noto, da letteratura, come i pazienti diabetici rispondano in maniera differente alla terapia con aspirina rispetto ai soggetti sani, evidenziando una risposta ridotta al farmaco, tanto da portare in ambito clinico alla coniazione del termine ‘aspirino-resistenza’. Data la mancanza di una trattazione matematica del fenomeno in letteratura, si è deciso di studiare il problema utilizzando un approccio modellistico di farmacodinamica, con un intento. Utilizzando informazioni biologiche ricavate da letteratura, si è sviluppato un modello, in parte compartimentale e in parte distribuito, che descrive: i) la cinetica dell’enzima COX-1 a partire dalla sua produzione all’interno dei megacariociti del midollo osseo fino a giungere nelle piastrine del sangue, ii) la farmacocinetica e la farmacodinamica dell’aspirina, ovvero la distribuzione del farmaco nel corpo e la sua interazione con l’enzima COX-1. Il modello è stato testato su dati sperimentali relativi al recupero di trombossano B2 sierico dopo la sospensione di aspirina in pazienti sani. Sono stati infine discussi meccanismi potenzialmente candidati a spiegare il fenomeno dell’aspirino-resistenza in pazienti diabetici.
Leksell, Janeth. "Diabetes-related blindness : studies of self-management, power, empowerment and health /". Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6262.
Pełny tekst źródłaLee, Kwanming. "Investigation on the correlation between methylglyoxal and diabetic complications : neurodegeneration and Osteoporosis". HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/589.
Pełny tekst źródłaLo, Che Sam, i mikewood@deakin edu au. "Relationship of nutritional and metabolic factors to non-invasive, indices of macrovascular disease in diabetes". Deakin University. School of Sciences, 1986. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051208.122550.
Pełny tekst źródłaSchenk, Johannes. "Examination of cardiovascular function in conscious hypertensive diabetic rats". Thesis, University of British Columbia, 1991. http://hdl.handle.net/2429/30318.
Pełny tekst źródłaMedicine, Faculty of
Anesthesiology, Pharmacology and Therapeutics, Department of
Graduate
Gin, Teck Ong Leslie. "The attenuation of chronic complications in experimental diabetes by l-arginine /". St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17871.pdf.
Pełny tekst źródłaЧернацька, Ольга Миколаївна, Ольга Николаевна Чернацкая, Olha Mykolaivna Chernatska, V. Dominas, R. Bessmertna, N. Bolotnikova i A. Gavrilenko. "Cardiovascular complications markers in hypertensive patients with type 2 diabetes mellitus". Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/55026.
Pełny tekst źródłaCleary, Liam. "HbA1c Test’s Accuracy as a Predictor for Diabetes with Complications Diagnosis: Further Analysis of the HbA1c Diabetes Mellitus Test". Thesis, Boston College, 2020. http://hdl.handle.net/2345/bc-ir:108925.
Pełny tekst źródłaHbA1c levels are the most frequently used test for diagnosis and prognosis of diabetes mellitus. Recent studies have shown the biases this test has in particular cohorts, that was not noted when it was originally accepted by the American Diabetes Association in 2008. This study examined how these biases affect HbA1c’s ability as a predictor for complications that arise due to diabetes in specific cohorts, those of ethnicity, age, weight, and other patient attributes, compared to other established diabetes prognosis tests. We discovered that both glucose and HbA1c share similar biases as predictors for particular cohorts (the high glucose, high BMI, Asian, African, and Hispanic descent cohorts), HbA1c works better as a predictor when it is combined with the results of a glucose test and more characteristics of the patient compared to a HbA1c test alone with fewer variables, and glucose and HbA1c are better predictors for different diseases, respectively, that may arise due to diabetes mellitus
Thesis (BA) — Boston College, 2020
Submitted to: Boston College. College of Arts and Sciences
Discipline: Departmental Honors
Discipline: Economics
Wong, Ching-keung, i 黃靜強. "The effects of streptozotocin-diabetes on adrenomedullin gene expression and peptide levels in the gastrointestinal system of therat". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B45011503.
Pełny tekst źródłaAdegbola, Saheed Adekunle. "Assessment of the level of adherence to treatment among type 2 diabetic patients in Matlala District Hospital". Thesis, University of Limpopo ( Medunsa Campus ), 2010. http://hdl.handle.net/10386/414.
Pełny tekst źródłaThe number of diabetic patients will continue to rise even in rural settings and the burden of this disease will continue to take its effect on the limited resources of these communities. The effect of such burden will be more pronounced if we are to add the various complications associated with substandard management of diabetes mellitus. The first step in assessing the level of care we give to this category of patients is to measure their level of adherence, in an effort to expose the pitfalls on both the side of the patients and on the side of the health care provider. The aim of the study is to assess the level of adherence to treatment among type2 diabetic patients in Matlala district hospital; Limpopo Province. This cross-sectional study used the convenience method of sampling with the aid of a tested, structured questionnaire, to obtain data from respondents between December 2009 and March 2010, a period of 4 months. The excel computer program was used for data capturing. Percentages and numbers were used for interpretation and cross tabulation was used to determine association. The result of the study indicated that 137 {70%} of the respondents adhere to diabetes treatment. There were two demographical characteristics that are significantly associated with non adherence: age {p=0.028} and employment status {p=0.018}. Of those respondents that keep their appointments, 98% are adherent to treatment. When considering reasons for poor adherence; 29% of respondents stated that the clinic did not have their pills, 16% stated that they forgot to take their medication and 14% stated that they travelled to visit ix and did not take enough pills with them. On the reasons for poor adherence to lifestyle: 29% of the respondents said that they were too old, 22% stated no specific reason, 13% struggled to motivate themselves and 10% simply forgot what to do. Most, 68%, of the respondents that adhere to the recommended use of medication agreed that they take it at meal time, 14% set a reminder, 8% employed the assistance of a treatment supporter and other respondents used other means to remember. The study revealed an above average level of adherence in my setting and it will be logical to assess whether this corresponds to the metabolic control expected of good adherence. More is needed to be done on the reasons why our patients do not adhere to both medication and lifestyle changes and each stake holder needs to address their short comings.
Vindedzis, Sally Ann. "The relationship between low blood thiamin levels in diabetes to thiamin intake and diabetic control". Curtin University of Technology, School of Public Health, 2008. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=118316.
Pełny tekst źródłaAlabi, Toyin Dorcas. "Effect of anchomanes difformis extract on biochemical and histological parameters in streptozotocin-induced diabetes and diabetic complications". Thesis, Cape Peninsula University of Technology, 2019. http://hdl.handle.net/20.500.11838/3074.
Pełny tekst źródłaDiabetes mellitus is one of the major health challenges facing the world today and it is not restricted by age, gender, education or urbanisation. Increased oxidative stress, inflammation and apoptosis are implicated in the pathogenesis of diabetes mellitus. The progression of diabetes mellitus leads to pathological events and alterations in many tissues of the body, thereby causing damage to these tissues and organs. Anchomanes difformis is has a strong ethnopharmacological relevance and it is known for its diverse traditional uses against hyperglycemia, kidney damage, pain, wounds, inflammation, onchocerciasis and gastrointestinal pathologies amongst others. Scientific investigations have been performed on some of these ethnobotanical claims on Anchomanes difformis using animal models. While some of these claims have been established scientifically, others are yet to be explored. In vivo experimental study on the leaves of Anchomanes difformis revealed its hypoglycemic effect, however, there is no information on the possible effect of Anchomanes difformis on oxidative stress, inflammatory mediators and apoptosis in diabetes mellitus. Therefore, this study investigated the potential benefits of Anchomanes difformis in increased oxidative stress, inflammation and apoptosis in a diabetic model. The study also assessed the ameliorative effect of Anchomanes difformis in diabetes-induced damage in the organs such as the liver, heart, kidney, testis and epididymis. The first phase of the study compared the antioxidant capacity and phytochemical characterisation of three different solvent extracts; aqueous, ethanolic and methanolic from the leaves and rhizome of Anchomanes difformis. All these six extracts (3 extracts each from the leaves and rhizome) exhibited antioxidant properties, however aqueous extract demonstrated the highest antioxidant potential, hence it was selected for further experiment in the study. Furthermore, certain bioactive compounds with antioxidant, antidiabetic and anti-inflammatory properties were identified in Anchomanes difformis. The second phase of the study involved the induction of diabetes, treatment with AD and standard drug and euthanasia followed by biochemical investigations in male Wistar rats. Type 2 diabetes was induced with two-weeks administration of 10% fructose, followed by a single intraperitoneal injection of streptozotocin (40mg/kgBW). Dosages of 200 and 400 mg/kgBW of Anchomanes difformis leaves extract were administered for six weeks to diabetic and normal rats which served as treatment controls. The effect of Anchomanes difformis on glycemic indices, body weights, relative organ weights, organ function markers, antioxidant statuses, inflammatory biomarkers, apoptosis and structural integrity of the liver, kidney, pancreas, testis and the epididymis were conducted. The administration of streptozotocin led to hyperglycemia, hyperlipidemia, body weight loss, increased inflammation, oxidative stress and apoptosis, reduced sperm concentration, viability and distorted sperm morphology. It also induced tissue damage in the liver, kidney, pancreas, testis and epididymis. Treatment with both doses of Anchomanes difformis improved organ functions, markedly reduced and repaired tissue damage in a dose-dependent manner and comparable to the standard drug; glibenclamide. Furthermore, Anchomanes difformis distinctly lowered blood glucose, abnormal lipid levels, enhanced antioxidant status, modulated inflammation, reduced apoptosis and increased sperm functions better than glibenclamide in diabetic rats. In conclusion, the protective and ameliorative properties of Anchomanes difformis projects it as a potential new, reliable therapeutic agent that should be explored and considered in the management of diabetes mellitus and its associated complications.
Yan, Yu North Kari E. "Diabetes susceptibility polymorphisms and risk of prediabetes and diabetes complications in the Atherosclerosis Risk in Communities ARIC study". Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2456.
Pełny tekst źródłaTitle from electronic title page (viewed Sep. 3, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the School of Public Health Epidemiology." Discipline: Epidemiology; Department/School: Public Health.
Berhan, Yonas. "Epidemiological studies of childhood diabetes and important health complications to the disease". Doctoral thesis, Umeå universitet, Pediatrik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85248.
Pełny tekst źródłaIngberg, Claes-Mårten. "Type 1 diabetes mellitus: Aspects of long-term complications and body composition". Doctoral thesis, Uppsala University, Department of Medical Sciences, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3287.
Pełny tekst źródłaStudies concerning social consequences, gastrointestinal and urinary tract symptoms were conducted in a population-based cohort comprising patients with long-standing type 1 diabetes and matched control persons. Three different questionnaires were sent by mail to diabetic patients and control persons. After a mean duration of 28.7±2.6 years, compared to the controls the diabetic patients showed an almost 10 times higher mortality, a lower employment rate and greater need for welfare benefits. These differences were mainly due to diabetic late complications. Education, housing conditions, life-style, civil state, alcohol and smoking habits were similar in the two groups. The prevalence of gastrointestinal symptoms was significantly higher in the diabetic patients than in the controls, and this was found to be attributable to the female diabetic patients. Female diabetic patients had been treated with antibiotics for urinary tract infections more often than controls, they experienced more social problems than controls in daily life because of urinary tract problems and used clamps to prevent wetting more often than did controls.
Body composition and bone mineral density were evaluated in parts of the cohort with long-standing type 1 diabetes and control persons in another population-based cohort comprising diabetic females aged 16-19 years with type 1 diabetes since childhood and matched controls. Besides a tendency to reduced abdominal fat mass in diabetic males, no difference was observed in fat mass, muscle mass or bone mineral density between the patients with long-standing type 1 diabetes and controls. Significant correlations were found between insulin dosage and whole body fat mass in diabetic females and between serum cholesterol levels and abdominal fat mass in diabetic males. The female adolescents had a higher body mass index than the controls, and their overweight was shown to consist almost entirely of an increased fat mass. The distribution of fat, expressed as abdominal-to-leg ratio, correlated significantly to HbA1c and daily dosage of insulin. Bone mineral density did not differ between the groups. IGF I was significantly lower both in patients with long-standing type 1 diabetes and in the adolescent diabetic females compared with their matched controls.
Ahmed, Ijaz. "Effects of Momordica charantia fruit juice on experimental diabetes and its complications". Thesis, University of Central Lancashire, 1999. http://clok.uclan.ac.uk/20106/.
Pełny tekst źródłaRobertson, Douglas Paul. "Oral complications of Type 1 diabetes mellitus in a non-smoking population". Thesis, University of Glasgow, 2011. http://theses.gla.ac.uk/3009/.
Pełny tekst źródłaInyang, Cornelia E. "Patients' Perceptions of Diet-Only Therapy in the Prevention of Diabetes Complications". Thesis, Walden University, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13807269.
Pełny tekst źródłaType 2 diabetes is a chronic metabolic disorder and the seventh leading cause of death in the United States. Type 2 diabetes is linked to many chronic diseases, including cardiovascular disease, stroke, and chronic kidney failure. African American adults have a high prevalence of Type 2 diabetes with early onset of diabetes complications. Poor dietary behavior is the primary cause of Type 2 diabetes and its complications, changing dietary behaviors can prevent the onset of diabetes complications or impede existing ones. The purpose of this phenomenological study was to explore patients’ perceptions of diet-only therapy in the prevention of diabetes complications. Face-to-face interviews were conducted with six African American adults with Type 2 diabetes between 40 to 64 years using purposeful sampling method. Health belief model formed the conceptual framework of the study. I applied inductive coding process and manually analyze data for themes. Participants expressed fear of diabetes complications, acknowledged effectiveness of dietary therapy, physician communication and strong family support in Type 2 diabetes management. Findings can produce positive social change among African American adults with type 2 diabetes. Patients can be motivated to change their dietary behaviors to prevent disability and death from diabetes complications. Adherence to diet can reduce medical costs associated with Type 2 diabetes and its complications at the individual, family, community, and government levels. Health care providers can apply the findings in their interactions with patients to provide a more patient-centered education that integrates patients’ cultural and dietary preferences to facilitate adoption of dietary interventions and long-term adherence.
Inyang, Cornelia Emmanuel. "Patients' Perceptions of Diet-Only Therapy in the Prevention of Diabetes Complications". ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/6588.
Pełny tekst źródłaVulesevic, Branka. "Endothelium and Cardiovascular Complications of Diabetes Mellitus: the Role of the Glyoxalase System". Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/33159.
Pełny tekst źródłaDuffy, Seamus. "Investigating genetic, epigenetic and biological ageing mechanisms in complications of type 1 diabetes". Thesis, Queen's University Belfast, 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.725835.
Pełny tekst źródłaGiardina, Marisol. "Knowledge-based supervised learning models for the assessment of type 2 diabetes complications". Thesis, University of Ulster, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.446252.
Pełny tekst źródłaRahman, Mushtaqur. "Evaluation of the effects of screening on the development of complications of diabetes". Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613270.
Pełny tekst źródłaRice, Ellen. "The impact of treatment and screening for diabetes complications on emergency department use". CONNECT TO ELECTRONIC THESIS, 2008. http://hdl.handle.net/1961/6863.
Pełny tekst źródłaSavu, Octavian. "Mechanisms of chronic complications of diabetes with focus on mitochondria and oxygen sensing". Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-764-1/.
Pełny tekst źródłaConstantino, Maria Ines. "The Utility of Electronic Health Records: A Study of diabetes and its complications". Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21211.
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