Gotowe bibliografie tematyczne / Dendrimers

Gotowa bibliografia na temat „Dendrimers”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 24 sierpnia 2024

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Artykuły w czasopismach na temat "Dendrimers"

1

Pattabiraman, K., M. Kameswari i M. Seenivasan. "Generalized Version of <i>ISI</i> Invariant for some Molecular Structures". Materials Science Forum 1048 (4.01.2022): 221–26. http://dx.doi.org/10.4028/www.scientific.net/msf.1048.221.

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Degree related topological invariants are the bygone and most victorioustype of graph invariants so far. In this article, we are interested in finding the generalized inverse indeg invariant of the nanostar dendrimers D[r],fullerene dendrimerNS4[r], and polymer dendrimerNS5[r]. Keywords: nanotubes; inverse indeg invariant; nanostar dendrimers; fullerene dendrimer; polymer dendrimer
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2

Qing, Xie, Zhen Wang, Mobeen Munir i Haseeb Ahmad. "Molecular Irregularity Indices of Nanostar, Fullerene, and Polymer Dendrimers". Journal of Chemistry 2020 (28.02.2020): 1–12. http://dx.doi.org/10.1155/2020/9437612.

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Dendrimers are highly branched organic macromolecules with successive layers of branch units surrounding a central core. Some properties like toxicity, entropy, and heats of vaporization of these dendrimers can be forecasted using topological indices. The present article is devoted to study of irregularity indices of three well-known classes of dendrimers, namely, nanostar dendrimer D[p], fullerene dendrimer NS4[p], and polymer dendrimerNS5[p], where p is the step size. We also see the relation of irregularity of these dendrimers on the step size graphically.
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3

Singh, Aditya, i Shubhrat Maheshwari. "DENDRIMERS FOR NEURO TARGETING". International Journal of Pharma Professional’s Research (IJPPR) 14, nr 1 (3.02.2023): 124–30. http://dx.doi.org/10.48165/ijppronline.2023.14111.

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Fortunately, the system is built with established principles that create a wide safety margin, making failure an occurrence with a low chance. The mechanical behaviour of the structure is numerically modelled in an effort to accurately reproduce the real response because it is difficult to assess such a probability level in an efficient manner. However, as the complexity of the numerical model is increased in an effort to increase accuracy and take specific mechanical behaviour into account, the model tends to become more time-consuming. Dendrimers are molecules with repeated branches that have a spherical three-dimensional appearance and form the centre of dendrimers. The drug molecules can be connected to the surface of the dendrimer and its sprouting branches in a structure termed a dendron, which is the dendrimer's sole functional unit. Dendrimers can be categorised by their generation number, which ranges from G0.5 to G5, depending on how they grow. Dendrimers come in a variety of forms, with some having significant uses in the administration of drugs, such as poly(amidoamine) (PAMAM) dendrimers, poly(propylene imine) (PPI) dendrimers, polyether copolyester (PEPE) dendrimers, PEGylated dendrimers, and peptide dendrimers. Dendrimers have an architecture that depends on things like sizes, forms, surface chemistries, stiffness or flexibility, architecture, or interior elemental compositions. This article provides an overview of a comprehensive and effective product design framework that supports concurrent dendrimer design optimization applications.
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4

Bober, Zuzanna, Dorota Bartusik-Aebisher i David Aebisher. "Application of Dendrimers in Anticancer Diagnostics and Therapy". Molecules 27, nr 10 (18.05.2022): 3237. http://dx.doi.org/10.3390/molecules27103237.

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The application of dendrimeric constructs in medical diagnostics and therapeutics is increasing. Dendrimers have attracted attention due to their compact, spherical three-dimensional structures with surfaces that can be modified by the attachment of various drugs, hydrophilic or hydrophobic groups, or reporter molecules. In the literature, many modified dendrimer systems with various applications have been reported, including drug and gene delivery systems, biosensors, bioimaging contrast agents, tissue engineering, and therapeutic agents. Dendrimers are used for the delivery of macromolecules, miRNAs, siRNAs, and many other various biomedical applications, and they are ideal carriers for bioactive molecules. In addition, the conjugation of dendrimers with antibodies, proteins, and peptides allows for the design of vaccines with highly specific and predictable properties, and the role of dendrimers as carrier systems for vaccine antigens is increasing. In this work, we will focus on a review of the use of dendrimers in cancer diagnostics and therapy. Dendrimer-based nanosystems for drug delivery are commonly based on polyamidoamine dendrimers (PAMAM) that can be modified with drugs and contrast agents. Moreover, dendrimers can be successfully used as conjugates that deliver several substances simultaneously. The potential to develop dendrimers with multifunctional abilities has served as an impetus for the design of new molecular platforms for medical diagnostics and therapeutics.
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5

Richter-Egger, Dana L., Hong Li i Sheryl A. Tucker. "Spectroscopic Investigations of Polyamido Amine Starburst Dendrimers with Reichardt's ET-30 Dye". Applied Spectroscopy 54, nr 8 (sierpień 2000): 1151–56. http://dx.doi.org/10.1366/0003702001950959.

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The association between Reichardt's ET-30 dye and amine- and carboxylate-terminated polyamido amine (PAMAM) dendrimers was investigated and shown to be different from results reported for micelles and traditional polymers. The absorption spectra illustrated that the solvatochromic, microenvironmental polarity probe associated with PAMAM dendrimers in less polar regions with a polarity comparable to 1-decanol. Model compounds that mimic PAMAMs' surface groups and branching moieties were used to better define the associated dye's location and demonstrated that ET-30 penetrated beyond the dendrimer's surface groups, into the interfacial region. Additionally, changing sample preparation methods controlled the nature and extent of the dye/dendrimer association. Under certain experimental conditions, the dye/dendrimer complexes formed large aggregates.
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6

Chirag M, Gowda D V, Sathish Babu i Famna Roohi N K. "A Comprehensive review on Dendrimers in current advanced Drug delivery". International Journal of Research in Pharmaceutical Sciences 11, nr 1 (5.02.2020): 1055–66. http://dx.doi.org/10.26452/ijrps.v11i1.1936.

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In this particular review, it is been noted that Dendrimers are novel three-dimensional globular nano-polymeric structure; having multiple functional groups on the surface enhances their function. Synonymous terms for dendrimer include arborols and cascade molecules. The importance of dendrimers in a large variety of fields has been detected, where the various types of dendrimers helps in various fields of drug delivery with the different types of dendrimers with the generation. Hence the dendrimer gains more attention from researchers among various nano-materials. Convenient synthesis of the structure makes them as a good nano-material for drug delivery. In recent, dendrimers showed their activity in different drug delivery systems having properties like cancer targeting, anti-bacterial, ocular drug delivery, etc.. The future direction about the dendrimers are been discussed. The present review is focused on types of dendrimers like Polypropylene Imine dendrimer (PPI), Poly(amidoamine) dendrimers (PAMAM), Poly-l-lysine dendrimers, Type of Frechet’s dendrimer, Core-shell tecto dendrimers, Chiral dendrimers, Liquid crystalline dendrimers, Peptide dendrimers, Multiple antigen peptide dendrimers, Glyco-dendrimers, Hybrid dendrimers, Polyester dendrimers in which among these type of dendrimers, the Polypropylene Imine dendrimer (PPI) and Poly(amidoamine) dendrimers are found to be good carriers for various targeting site, Dendrimers are synthesized through various methods like Divergent method, Convergent method, Hyper cores and branched monomer growth method, Double exponential growth method, Click chemistry method, recent advances in dendrimers are used in the Anti-cancer delivery, Anti-bacterial delivery, oral route delivery, pulmonary drug delivery, transdermal drug delivery, ocular delivery, and targeted drug delivery the safety aspects, and future strategies are also been discussed in the below article.
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7

Szota, Magdalena, Katarzyna Reczyńska-Kolman, Elżbieta Pamuła, Olga Michel, Julita Kulbacka i Barbara Jachimska. "Poly(amidoamine) Dendrimers as Nanocarriers for 5-Fluorouracil: Effectiveness of Complex Formation and Cytotoxicity Studies". International Journal of Molecular Sciences 22, nr 20 (16.10.2021): 11167. http://dx.doi.org/10.3390/ijms222011167.

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Two generations of positively charged poly(amidoamine) dendrimers (PAMAMs) were selected for study as potential carriers for the anticancer drug 5-fluorouracil (5FU), a drug primarily used in the treatment of colorectal cancer. Analytical techniques, such as UV-Vis spectrophotometry, NMR Spectroscopy and Laser Doppler Velocimetry (LDV), have shown that the most critical factor determining the formation of a PAMAM–5FU complex is the starting components’ protonation degree. The tests confirmed the system’s ability to attach about 20 5FU molecules per one dendrimer molecule for the G4PAMAM dendrimer and about 25 molecules for the G6PAMAM dendrimer, which gives a system yield of 16% for the fourth generation and 5% for sixth generation dendrimers. Additionally, using the QCM-D method, the adsorption efficiency and the number of drug molecules immobilized in the dendrimer structure were determined. A new aspect in our study was the determination of the change in zeta potential (ζ) induced by the immobilization of 5FU molecules on the dendrimer’s outer shell and the importance of this effect in the direct contact of the carrier with cells. Cytotoxicity tests (resazurin reduction and MTS tests) showed no toxicity of dendrimers against mouse fibroblast cells (L929) and a significant decrease in cell viability in the case of four human malignant cell lines: malignant melanoma (A375), glioblastoma (SNB-19), prostate cancer (Du-145) and colon adenocarcinoma (HT-29) during incubation with PAMAM–5FU complexes. The purpose of our work was to investigate the correlation between the physicochemical properties of the carrier and active substance and the system efficiency and optimizing conditions for the formation of an efficient system based on PAMAM dendrimers as nanocarriers for 5-fluorouracil. An additional aspect was to identify potential application properties of the complexes, as demonstrated by cytotoxicity tests.
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8

Milenin, Sergey A., Elizaveta V. Selezneva, Pavel A. Tikhonov, Viktor G. Vasil’ev, Alexander I. Buzin, Nikolay K. Balabaev, Andrey O. Kurbatov i in. "Hybrid Polycarbosilane-Siloxane Dendrimers: Synthesis and Properties". Polymers 13, nr 4 (17.02.2021): 606. http://dx.doi.org/10.3390/polym13040606.

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A series of carbosilane dendrimers of the 4th, 6th, and 7th generations with a terminal trimethylsilylsiloxane layer was synthesized. Theoretical models of these dendrimers were developed, and equilibrium dendrimer conformations obtained via molecular dynamics simulations were in a good agreement with experimental small-angle X-ray scattering (SAXS) data demonstrating molecule monodispersity and an almost spherical shape. It was confirmed that the glass transition temperature is independent of the dendrimer generation, but is greatly affected by the chemical nature of the dendrimer terminal groups. A sharp increase in the zero-shear viscosity of dendrimer melts was found between the 5th and the 7th dendrimer generations, which was qualitatively identical to that previously reported for polycarbosilane dendrimers with butyl terminal groups. The viscoelastic properties of high-generation dendrimers seem to follow some general trends with an increase in the generation number, which are determined by the regular branching structure of dendrimers.
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9

Bosch, Paula, Desislava Staneva, Evgenia Vasileva-Tonkova, Petar Grozdanov, Ivanka Nikolova, Rositsa Kukeva, Radostina Stoyanova i Ivo Grabchev. "New Poly(Propylene Imine) Dendrimer Modified with Acridine and Its Cu(II) Complex: Synthesis, Characterization and Antimicrobial Activity". Materials 12, nr 18 (18.09.2019): 3020. http://dx.doi.org/10.3390/ma12183020.

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A second-generation poly(propylene imine) dendrimer modified with acridine and its Cu(II) complex have been synthesized for the first time. It has been found that two copper ions form complexes with the nitrogen atoms of the dendrimeric core by coordinate bonds. The new compounds have been characterized by nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), fourier-transform infrared spectroscopy (FTIR) and fluorescence spectroscopy. The spectral characteristics of the modified dendrimer have been measured in different organic solvents, and a negative fluorescence solvatochromism has been observed. The antimicrobial activity of the dendrimers has been tested against model pathogenic microorganisms in agar and by broth dilution method. The cotton fabric treated with both dendrimers has been evaluated towards pathogenic microorganisms. The obtained modified cotton fabrics have been shown to hamper bacterial growth and to prevent biofilm formation. Dendrimer cytotoxicity has been investigated in vitro in the model HEp-2 cell line.
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10

Nayak, Jyoti, Pushpendra Kumar Tripathi, Navneet Kumar Verma i Jai Narayan Mishra. "Pharmaceutical Applications and Safety Review of Dendrimers". International Journal of Pharmaceutical Sciences and Nanotechnology 12, nr 4 (31.07.2019): 4565–72. http://dx.doi.org/10.37285/ijpsn.2019.12.4.1.

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This article describes the innovative approaches to overcome the cationic toxicity inherently associated with the dendrimers. A dendrimer is a macromolecule characterized by its highly branched 3D structure that provides a high degree of surface functionality and versatility. The toxicity is attributed to the interaction of surface cationic charge of dendrimers with negatively charged biological membranes in vivo. Dendrimer toxicity in biological system is generally characterized by hemolytic toxicity, cytotoxicity and hematological toxicity. To minimize this toxicity, two strategies have been utilized; first, designing and synthesis of biocompatible dendrimers; and second, masking of peripheral charge of dendrimers by surface engineering. Biocompatible dendrimers can be synthesized by employing biodegradable core and branching units or utilizing intermediates of various metabolic pathways. Dendrimer biocompatibility has been evaluated in vitro and in vivo for efficient presentation of biological performance. Neutral and negatively charged dendrimers do not interact with biological environment and hence are compatible for clinical applications as elucidated by various studies examined in this review. Chemical modification of the surface is an important strategy to overcome the toxicity problems associated with the dendrimers.
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Rozprawy doktorskie na temat "Dendrimers"

1

Wang, Yang. "Novel amphiphilic dendrimers as nanovectors for siRNA delivery". Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4017.

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Les dendrimères, font partie d'une famille particulière de polymères synthétiques, pouvant être utilisés comme nanovecteurs pour l'administration de médicaments grâce à leur structure polyvalente et leur action coopérative, ces fonctions étant confinées dans un volume de taille nanométrique. Notre groupe a récemment démontré que de petites unités dendritiques amphiphiles pouvaient s'auto-assembler en dendrimères supramoléculaires pouvant délivrer du siARN, avec une efficacité similaire à celle des dendrimères de grande génération construits de manière covalente. Dans cette thèse, ans le but de explorer des nouveaux dendrimères amphiphiles possédant des propriétés particulières d'auto-assemblage pour la délivrance de médicaments, j'ai synthétisé et caractérisé deux familles de dendrimères amphiphiles, à savoir des dendrimères bola-amphiphiliques de type PAMAM ainsi que des dendrimères amphiphiles biodégradables de type poly(aminoester). Leurs propriétés physico-chimiques et l'activité biologique pour la délivrance de siARN ont été étudiées. Nos résultats soulignent qu'elles constituent de nouveaux nanotransporteurs prometteurs pour la délivrance d'acide nucléique, voie dans laquelle nous poursuivons activement nos efforts
Dendrimers, a special family of synthetic polymers, emerge as appealing nanovectors for drug delivery thanks to their unique precisely-controlled achitecture along with multivalency and cooperativity confined within a nanosized volume. Our group has recently demonstrated that small amphiphilic dendrons could self-assemble into supramolecular dendrimers, which mimick the covalently constructed high generation dendrimers and effectively deliver siRNA therapeutics in vitro and in vivo. In order to further explore novel amphiphilic dendrimers with special self-assembly properties for nucleic acid delivery, in this Ph.D thesis, I have synthesized and characterized two families of amphiphilic dendrimers, namely bola-amphiphilic PAMAM dendrimer and biodegradable amphiphilic poly(aminoester) dendrimer. Their physico-chemical properties and biological activity for siRNA delivery have been investigated. Our results demonstrate that they may constitute, via supramolecular self-assembling, effective and promising nanocarriers for nuclide acid delivery, in which we are actively pursuing our effort
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2

Deakin, Peter C. "Optoelectronic dendrimers". Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510945.

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Frampton, Michael John. "Electroluminescent dendrimers". Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270614.

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4

Huang, Adela Ya-Ting. "Advancing dendrimer synthesis : solid-phase and self-assembly approach". Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0146.

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Les dendrimères sont très prometteurs du fait de leur structure unique et de leur multivalence. Cependant, leur synthèse souffre de problèmes de défauts de structure et de présence de produits secondaires très similaires. Des approches synthétiques alternatives sont donc fortement désirées. L'objectif de ma thèse consiste à explorer la synthèse sur support solide et l’approche d'autoassemblage pour la préparation de dendrimères.La première partie de ma thèse se concentre sur la synthèse de dendrimères en phase solide. Nous avons tout d'abord développé une méthode de synthèse pour les dendrimères poly(amidoamines) basée sur la chimie des peptides. Nous avons ensuite construit une petite bibliothèque de dendrimères de type triazine en faisant varier la taille et la terminaison des dendrimères pour créer une variété de dendrimères. Nous avons aussi tenté de synthétiser des dendrimères poly(aminoesters) bien que nous n'ayons pu les obtenir du fait du caractère labile de ces dendrimères.La deuxième partie de ma thèse vise à appliquer l’approche d'autoassemblage pour la construction de dendrimères supramoléculaires comme théranostiques combinant l'imagerie et la thérapie. Nous avons synthétisé un petit dendrimère amphiphile portant DOTA pour chélater le Gd (III). Ce dendrimère est capable de s'autoassembler en supramolécule et d’encapsuler l’agent anticancéreux doxorubicine, pour construire des agents théranostiques à base de dendrimères multivalents.L’ensemble de ma thèse se consacre au développement de stratégies en phase solide et de l'autoassemblage pour construire des dendrimères pour les applications dans les domaines biomédicaux et des matériaux
Dendrimers hold great promise for wide applications thanks to their unique structural architecture and multivalent cooperativity. However, dendrimer synthesis often suffers from structural defects caused by incomplete reactions and difficulties associated with purification. Consequently, alternative synthetic approaches to overcome the limitations of current dendrimer synthesis are in high demand.My first PhD project mainly focuses on establishing novel strategies and methodologies for solid-phase dendrimer synthesis with advantages of convenient complete synthesis and easy purification procedures. We first developed a new and concise solid-phase synthesis of PAMAM dendrimers based on the adoption of peptide synthesis chemistry. We then constructed a small library of triazine dendrimers varying in generations and surface groups with a view to rapidly synthesizing dendrimers with structural diversity. We also strived to synthesize poly(aminoester) dendrimers although we had difficult to get it thorough.My second PhD program aims to apply the self-assembly approach for constructing supramolecular dendrimer theranostics. A small DOTA-conjugated amphiphilic dendrimer with Gd(III)-chelation was synthesized and self-assembled into supramolecular nanomicelles to encapsulate the anticancer drug doxorubicin. The obtained system constitutes a multivalent nanotheranostic to combine imaging purpose with therapeutic utility.In summary, my PhD program mainly contributes to elaborating strategies for dendrimer synthesis using both solid-phase method and self-assembly approach in the view to realizing and broadening their applications in the arenas of biomedical and material sciences
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5

Wang, Yang. "Novel amphiphilic dendrimers as nanovectors for siRNA delivery". Electronic Thesis or Diss., Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4017.

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Les dendrimères, font partie d'une famille particulière de polymères synthétiques, pouvant être utilisés comme nanovecteurs pour l'administration de médicaments grâce à leur structure polyvalente et leur action coopérative, ces fonctions étant confinées dans un volume de taille nanométrique. Notre groupe a récemment démontré que de petites unités dendritiques amphiphiles pouvaient s'auto-assembler en dendrimères supramoléculaires pouvant délivrer du siARN, avec une efficacité similaire à celle des dendrimères de grande génération construits de manière covalente. Dans cette thèse, ans le but de explorer des nouveaux dendrimères amphiphiles possédant des propriétés particulières d'auto-assemblage pour la délivrance de médicaments, j'ai synthétisé et caractérisé deux familles de dendrimères amphiphiles, à savoir des dendrimères bola-amphiphiliques de type PAMAM ainsi que des dendrimères amphiphiles biodégradables de type poly(aminoester). Leurs propriétés physico-chimiques et l'activité biologique pour la délivrance de siARN ont été étudiées. Nos résultats soulignent qu'elles constituent de nouveaux nanotransporteurs prometteurs pour la délivrance d'acide nucléique, voie dans laquelle nous poursuivons activement nos efforts
Dendrimers, a special family of synthetic polymers, emerge as appealing nanovectors for drug delivery thanks to their unique precisely-controlled achitecture along with multivalency and cooperativity confined within a nanosized volume. Our group has recently demonstrated that small amphiphilic dendrons could self-assemble into supramolecular dendrimers, which mimick the covalently constructed high generation dendrimers and effectively deliver siRNA therapeutics in vitro and in vivo. In order to further explore novel amphiphilic dendrimers with special self-assembly properties for nucleic acid delivery, in this Ph.D thesis, I have synthesized and characterized two families of amphiphilic dendrimers, namely bola-amphiphilic PAMAM dendrimer and biodegradable amphiphilic poly(aminoester) dendrimer. Their physico-chemical properties and biological activity for siRNA delivery have been investigated. Our results demonstrate that they may constitute, via supramolecular self-assembling, effective and promising nanocarriers for nuclide acid delivery, in which we are actively pursuing our effort
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6

Huang, Adela Ya-Ting. "Advancing dendrimer synthesis : solid-phase and self-assembly approach". Electronic Thesis or Diss., Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0146.

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Les dendrimères sont très prometteurs du fait de leur structure unique et de leur multivalence. Cependant, leur synthèse souffre de problèmes de défauts de structure et de présence de produits secondaires très similaires. Des approches synthétiques alternatives sont donc fortement désirées. L'objectif de ma thèse consiste à explorer la synthèse sur support solide et l’approche d'autoassemblage pour la préparation de dendrimères.La première partie de ma thèse se concentre sur la synthèse de dendrimères en phase solide. Nous avons tout d'abord développé une méthode de synthèse pour les dendrimères poly(amidoamines) basée sur la chimie des peptides. Nous avons ensuite construit une petite bibliothèque de dendrimères de type triazine en faisant varier la taille et la terminaison des dendrimères pour créer une variété de dendrimères. Nous avons aussi tenté de synthétiser des dendrimères poly(aminoesters) bien que nous n'ayons pu les obtenir du fait du caractère labile de ces dendrimères.La deuxième partie de ma thèse vise à appliquer l’approche d'autoassemblage pour la construction de dendrimères supramoléculaires comme théranostiques combinant l'imagerie et la thérapie. Nous avons synthétisé un petit dendrimère amphiphile portant DOTA pour chélater le Gd (III). Ce dendrimère est capable de s'autoassembler en supramolécule et d’encapsuler l’agent anticancéreux doxorubicine, pour construire des agents théranostiques à base de dendrimères multivalents.L’ensemble de ma thèse se consacre au développement de stratégies en phase solide et de l'autoassemblage pour construire des dendrimères pour les applications dans les domaines biomédicaux et des matériaux
Dendrimers hold great promise for wide applications thanks to their unique structural architecture and multivalent cooperativity. However, dendrimer synthesis often suffers from structural defects caused by incomplete reactions and difficulties associated with purification. Consequently, alternative synthetic approaches to overcome the limitations of current dendrimer synthesis are in high demand.My first PhD project mainly focuses on establishing novel strategies and methodologies for solid-phase dendrimer synthesis with advantages of convenient complete synthesis and easy purification procedures. We first developed a new and concise solid-phase synthesis of PAMAM dendrimers based on the adoption of peptide synthesis chemistry. We then constructed a small library of triazine dendrimers varying in generations and surface groups with a view to rapidly synthesizing dendrimers with structural diversity. We also strived to synthesize poly(aminoester) dendrimers although we had difficult to get it thorough.My second PhD program aims to apply the self-assembly approach for constructing supramolecular dendrimer theranostics. A small DOTA-conjugated amphiphilic dendrimer with Gd(III)-chelation was synthesized and self-assembled into supramolecular nanomicelles to encapsulate the anticancer drug doxorubicin. The obtained system constitutes a multivalent nanotheranostic to combine imaging purpose with therapeutic utility.In summary, my PhD program mainly contributes to elaborating strategies for dendrimer synthesis using both solid-phase method and self-assembly approach in the view to realizing and broadening their applications in the arenas of biomedical and material sciences
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7

Liang, Liyuan. "Inorganic Aspects of “Click” Chemistry in Polymers and Dendrimers : synthesis, Nanoparticle Stabilization and Catalysis". Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14277/document.

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La thèse concerne les aspects inorganiques de la réaction des alcynes terminaux avec les azotures, la principale des réactions dites ”click”. La catalyse de cette réaction par des dendrimères centrés sur le cuivre (I) nous a permis de mettre en évidence des effets dendritiques originaux. Les assemblages dendritiques et polymériques fonctionnels réalisés à l’aide cette réaction “click”, en particulier avec des carboranes, nous ont conduits à la stabilisation de nanoparticules d’or et de palladium à partirde cations coordonnés aux triazoles “click”. La catalyse très efficace dans aqueux milieu et dans les conditions ambiantes de formation de liaison carbone-carbone a été réalisée à l’aide de très faibles quantités de ces nanoparticulesde palladium stabilisées
The thesis concerns aspects of inorganic reaction between organic azides and terminal alkynes, the main “click” reactions. Catalysis of this reaction by copper (I)-centered dendrimers allowed us to highlight the dendritic effects originals. The dendritic and polymeric functional assemblies produced using the "click" reaction, especially with carboranes, led us to the stabilization of gold nanoparticles and palladium from cation-coordinated "click" triazole. The highly efficient catalysis in aqueous medium under ambient conditions of formation of carbon-carbon was carried out using very small amounts of stabilized palladium nanoparticles
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8

Wang, Qi. "Synthesis of multi-functional dendrimers for targeted delivery of nucleic acids". Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4068/document.

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Nous avons démontré que structurellement flexibles poly(amidoamine) (PAMAM) dendrimères sont efficaces système de livraison de siRNA in vitro et in vivo récemment. Nous voulons mener une enquête plus approfondie sur la livraison de siRNA ciblés en utilisant des dendrimères conjugués avec des ligands spécifiques ou d'anticorps, qui peuvent reconnaître les récepteurs correspondants ou des protéines exprimées à la surface des cellules. De cette façon, le siRNA peuvent être livrés spécifiquement aux cellules d'intérêt, conduisant à une délivrance ciblée, ce qui peut améliorer l'efficacité livraison et de réduire la toxicité en évitant les interactions non spécifiques et à des doses plus faibles. À cette fin, nous avons développé des dendrimères portant une chaîne PEG long et un dendron individu polyvalent. La chaîne PEG est de libérer l'encombrement stérique entre dendrimère et ligand / anticorps, tandis que le dendron multivalent fournit une plate-forme d'une conjugaison contrôlable de ligands. Par ailleurs, nous avons également conçu et synthétisé une autre dendrimères PEGylées portant un groupe thiol libre pour la préparation des anticorps / dendrimère conjugués
We have demonstrated that structurally flexible poly(amido)amine (PAMAM) dendrimers are efficient siRNA delivery system in vitro and in vivo recently. We would like to undertake further investigation on targeted siRNA delivery using dendrimers conjugated with specific ligands or antibodies, which can recognize the corresponding receptors or proteins expressed on the cell surface. In this way, siRNA can be delivered specifically to the cells of interest, leading to targeted delivery, which can further improve the delivery efficiency and reduce the toxicity by avoiding non-specific interactions and at lower doses. To this end, we have developed dendrimers bearing a long PEG chain and an individual multivalent dendron. The PEG chain is to release the steric congestion between dendrimer and ligand/antibody, whereas the multivalent dendron provides a platform of a controllable conjugation for ligands. Besides, we also designed and synthesized another PEGylated dendrimers bearing a free thiol group for the preparation of antibody/dendrimer conjugates
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Appelhans, Dietmar, i Brigitte Voit. "Dendrimere als vielseitige, nano-skalige Objekte für biomimetische, biomedizinische und katalytische Fragestellungen". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1188377327860-73166.

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With their three-dimensional macromolecular structure and shape, and with their tuneable properties in both the inner and outer spheres, dendrimers are ideal model compounds in the nanometre range between 1 and 10 nm. The possibility to combine different properties within one macromolecule destines them for use in various high-end research fields such as medicine, pharmacy, biology, supramolecular chemistry, nanotechnology and material sciences. On the basis of their high end-group density and a compact, highly branched molecular structure, dendrimers are successfully investigated as carrier systems for active substances and metal ions (e.g. contrast agents for the visualisation of blood vessels), as templates for metal nanoparticles, as artificial enzymes with defined functions, and as materials for catalysis
Dendrimere sind aufgrund ihrer dreidimensionalen Makromolekülstruktur und -form und ihrer steuerbaren Eigenschaften sowohl an der Oberfläche als auch im Molekülinneren ideale Modellverbindungen im Nanometerbereich – sie sind zwischen 1 und 10 nm groß –, die vorzugsweise in der Medizin, Pharmazie, Biologie, Supramolekularen Chemie, Nanotechnologie und den Materialwissenschaften eingesetzt werden. Aufgrund ihrer hohen Endgruppendichte und der kompakten, stark verzweigten Molekülform werden Dendrimere unter anderem als Trägermaterialien und Transportsysteme für Wirkstoffe und Metallionen, zum Beispiel als Kontrastmittel zur Visualisierung von Organen und Blutgefäßen, als Template für metallische Nanopartikel, zur Erzeugung künstlicher Enzymfunktionen und in der Katalyse erfolgreich untersucht
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Dirksen, Anouk. "Photoinduced processes in dendrimers". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/87283.

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Książki na temat "Dendrimers"

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Caminade, Anne-Marie, Cédric-Olivier Turrin, Régis Laurent, Armelle Ouali i Béatrice Delavaux-Nicot, red. Dendrimers. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119976530.

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de Meijere, Armin. Dendrimers. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/3-540-69779-9.

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Vögtle, Fritz, red. Dendrimers III. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/3-540-44924-8.

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Schalley, Christoph A., i Fritz Vögtle, red. Dendrimers V. Berlin, Heidelberg: Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/bfb0121312.

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Vögtle, Fritz, i Christoph A. Schalley, red. Dendrimers IV. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/3-540-45003-3.

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Vögtle, Fritz, red. Dendrimers II. Berlin, Heidelberg: Springer Berlin Heidelberg, 2000. http://dx.doi.org/10.1007/3-540-46577-4.

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Colonna, Barbara. Carbohydrate dendrimers. Birmingham: University of Birmingham, 1998.

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Campagna, Sebastiano. Designing dendrimers. Hoboken, NJ: Wiley, 2012.

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Mehra, Neelesh Kumar, i Keerti Jain. Dendrimers in Nanomedicine. Redaktorzy Neelesh Kumar Mehra i Keerti Jain. First edition. | Boca Raton : CRC Press, 2021.: CRC Press, 2021. http://dx.doi.org/10.1201/9781003029915.

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R, Arshady, i Guyot Alain, red. Dendrimers, assemblies, nanocomposites. London: Citus Books, 2002.

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Części książek na temat "Dendrimers"

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Feuerbacher, Nina, i Fritz Vögtle. "Iterative Synthesis in Organic Chemistry". W Dendrimers, 1–18. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/3-540-69779-9_1.

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Narayanan, Venkatraj V., i George R. Newkome. "Supramolecular Chemistry within Dendritic Structures". W Dendrimers, 19–77. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/3-540-69779-9_2.

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Majoral, Jean-Pierre, i Anne-Marie Caminade. "Divergent Approaches to Phosphorus-Containing Dendrimers and their Functionalization". W Dendrimers, 79–124. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/3-540-69779-9_3.

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Seebach, Dieter, P. Beat Rheiner, Guy Greiveldinger, Thomas Butz i Holger Sellner. "Chiral Dendrimers". W Dendrimers, 125–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/3-540-69779-9_4.

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Schlüter, A. D. "Dendrimers with Polymeric Core: Towards Nanocylinders". W Dendrimers, 165–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/3-540-69779-9_5.

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Venturi, Margherita, Scolastica Serroni, Alberto Juris, Sebastiano Campagna i Vincenzo Balzani. "Electrochemical and Photochemical Properties of Metal-Containing Dendrimers". W Dendrimers, 193–228. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/3-540-69779-9_6.

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Caminade, Anne-Marie. "Syntheses of Dendrimers and Dendrons". W Dendrimers, 1–33. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119976530.ch1.

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Laurent, Régis, i Anne-Marie Caminade. "Catalysis with Dendrimers in Particular Media". W Dendrimers, 215–38. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119976530.ch10.

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Laurent, Régis, i Anne-Marie Caminade. "Heterogeneous Catalysis with Dendrimers". W Dendrimers, 239–65. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119976530.ch11.

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Laurent, Régis, i Anne-Marie Caminade. "Dendrimers Inside Materials". W Dendrimers, 267–311. Chichester, UK: John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119976530.ch12.

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Streszczenia konferencji na temat "Dendrimers"

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Dreyer, Christian, Alfred Blume, Monika Bauer, Jörg Bauer i Jens Neumann-Rodekirch. "Triazine based Dendrimers". W The 4th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2000. http://dx.doi.org/10.3390/ecsoc-4-01879.

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Tato, José, Mercedes Alcalde, Aida Jover, Francisco Meijide, Luciano Galantini, Nicolae Pavel i Alvaro Antelo. "Host-Guest Supramolecular Dendrimers". W The 11th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2007. http://dx.doi.org/10.3390/ecsoc-11-01357.

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Cumpstey, Neil, Raghu N. Bera, Ruth E. Harding, Paul L. Burn i Ifor D. W. Samuel. "Highly branched phosphorescent dendrimers". W Optics & Photonics 2005, redaktorzy Zakya H. Kafafi i Paul A. Lane. SPIE, 2005. http://dx.doi.org/10.1117/12.620443.

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REYMOND, JEAN-LOUIS. "PEPTIDE DENDRIMERS AND POLYCYCLIC PEPTIDES". W 23rd International Solvay Conference on Chemistry. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814603836_0003.

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Lewis, Donald G., Larissa B. Krasnova, Philip J. Skinner i Valery V. Fokin. "Conductive dendrimers obtained by click chemistry". W SPIE NanoScience + Engineering, redaktorzy Stefano Cabrini i Taleb Mokari. SPIE, 2010. http://dx.doi.org/10.1117/12.860879.

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Taylor, Richard, Yuhua Lu i Fahad Alminderej. "A Divergent Synthesis of Polyurethane Dendrimers". W The 17th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-d003.

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Hasni, Roslan, i Nabeel Ezzulddin Arif. "Fourth order connectivity index of polyphenylene dendrimers". W PROCEEDINGS OF THE 20TH NATIONAL SYMPOSIUM ON MATHEMATICAL SCIENCES: Research in Mathematical Sciences: A Catalyst for Creativity and Innovation. AIP, 2013. http://dx.doi.org/10.1063/1.4801165.

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Calabretta, Aurora. "Modelling Hydrogen Storage in 3D Polyphenylene Dendrimers". W STRUCTURAL AND ELECTRONIC PROPERTIES OF MOLECULAR NANOSTRUCTURES: XVI International Winterschool on Electronic Properties of Novel Materials. AIP, 2002. http://dx.doi.org/10.1063/1.1514193.

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Milowska, Katarzyna, Rafael Gomez-Ramirez, Francisco Javier de la Mata, Teresa Gabryelak i Maria Bryszewska. "Carbosilane dendrimers affect the fibrillation of α-synuclein". W THE SECOND ICRANET CÉSAR LATTES MEETING: Supernovae, Neutron Stars and Black Holes. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4937302.

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Nowacka, Olga, Katarzyna Miłowska, Maksim Ionov i Maria Bryszewska. "Influence of PAMAM dendrimers on the human insulin". W THE SECOND ICRANET CÉSAR LATTES MEETING: Supernovae, Neutron Stars and Black Holes. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4937306.

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Raporty organizacyjne na temat "Dendrimers"

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Kukowska Latallo, J. F., A. U. Bielinska, C. Chen, M. Rymaszewski i D. A. Tomalia. Gene Transfer Using StarburstTM Dendrimers. Fort Belvoir, VA: Defense Technical Information Center, styczeń 1998. http://dx.doi.org/10.21236/ada406313.

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Lin, Terri C. Poly(amido amine) Dendrimers in Supercapacitors. Office of Scientific and Technical Information (OSTI), sierpień 2013. http://dx.doi.org/10.2172/1091321.

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Edwards, Stephanie L. The Use of Dendrimers in Supercapacitors. Office of Scientific and Technical Information (OSTI), marzec 2013. http://dx.doi.org/10.2172/1068956.

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Rebane, Aleksander. Two-Photon Porphyrin Core Dendrimers for Optical Power Limiting. Fort Belvoir, VA: Defense Technical Information Center, wrzesień 2006. http://dx.doi.org/10.21236/ada495180.

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Uppuluri, Srinivas, Petar R. Dvornic, June W. Klimash, Peter I. Carver i Nora C. Tan. The Properties of Dendritic Polymers I: Generation 5 Poly(amidoamine) Dendrimers. Fort Belvoir, VA: Defense Technical Information Center, maj 1998. http://dx.doi.org/10.21236/ada346880.

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Thayumanavan, Sankaran. Design, Synthesis and Study of Dendrimers as Nanoscaffolds for Solar Energy Harvest. Office of Scientific and Technical Information (OSTI), styczeń 2008. http://dx.doi.org/10.2172/922581.

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Thayumanavan, Sankaran. Design, Synthesis and Study of Dendrimers as Nanoscaffolds for Solar Energy Harvest. Office of Scientific and Technical Information (OSTI), styczeń 2008. http://dx.doi.org/10.2172/946075.

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Uppuluri, Srinivas, Petar R. Dvornic, Nora C. Beck Tan i Gary Hagnauer. The Properties of Dendritic Polymers 2: Generation Dependence of the Physical Properties of Poly(amidoamine) Dendrimers. Fort Belvoir, VA: Defense Technical Information Center, styczeń 1999. http://dx.doi.org/10.21236/ada359423.

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Arias, Eduardo, Ivana Moggio i Ronald Ziolo. Liquid Crystals of Dendron-Like Pt Complexes Processable Into Nanofilms Dendrimers. Phase 2. Cholesteric Liquid Crystal Glass Platinum Acetylides. Fort Belvoir, VA: Defense Technical Information Center, sierpień 2014. http://dx.doi.org/10.21236/ada619975.

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C. J. Bardeen, T. J. Martinez i J. S. Moore. Final Technical Report - A Combined Synthetic, Spectroscopic, and Theoretical Approach to the Rational Design of Photophysical and Photochemical Properties of Dendrimers. Office of Scientific and Technical Information (OSTI), październik 2006. http://dx.doi.org/10.2172/892903.

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