Rozprawy doktorskie na temat „Dementia, vascular”
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Cornett, Patricia F. "Risk Factors for Vascular Dementia". Thesis, University of North Texas, 2005. https://digital.library.unt.edu/ark:/67531/metadc4781/.
Pełny tekst źródłaHill, Jonathan. "Development of a Differential Neurocognitive Profile for Alzheimer’s Dementia and Vascular Dementia". Thesis, University of North Texas, 2013. https://digital.library.unt.edu/ark:/67531/metadc500158/.
Pełny tekst źródłaHecht, Moritz [Verfasser]. "The impact of vascular lesions in dementia / Moritz Hecht". Ulm : Universität Ulm, 2019. http://d-nb.info/1182430473/34.
Pełny tekst źródłaPurroy, Rodríguez Marina. "Canvis vasculars associats a l'envelliment en models animals de demència vascular". Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673556.
Pełny tekst źródłaLaukka, Erika Jonsson. "Cognitive functioning during the transition from normal aging to dementia /". Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-934-3/.
Pełny tekst źródłaEveritt, Alaina. "Differential Scoring Patterns on the Clock Drawing Test: a Comparison of Vascular Dementia and Alzheimer's Dementia". Thesis, University of North Texas, 2006. https://digital.library.unt.edu/ark:/67531/metadc5283/.
Pełny tekst źródłaSmith, Ronna M. "Cognitive and behavioral differences between Alzheimer's disease and vascular dementia /". View abstract, 2001. http://wilson.ccsu.edu/theses/etd-2002-??/ThesisTitlePage.html.
Pełny tekst źródłaThesis advisor: C. Charles Mate-Kole. " ... in partial fulfillment of the requirements for the degree of Master of Arts in Psychology." Includes bibliographical references (leaves 36-44). Also available via the World Wide Web.
Rönnemaa, Elina. "Predictors of Dementia : Insulin, Fatty Acids and Vascular Risk Factors". Doctoral thesis, Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-164528.
Pełny tekst źródłaULSAM
Sakamoto, Maiko Spiers Mary. "Comparing Alzheimer's Disease and vascular dementia profiles on neuropsychological tests among Japanese elders /". Philadelphia, Pa. : Drexel University, 2009. http://hdl.handle.net/1860/3021.
Pełny tekst źródłaJones, Sari. "Cognitive functioning in the preclinical stages of Alzheimer's disease and vascular dementia /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-366-3/.
Pełny tekst źródłaHagnelius, Nils-Olof. "Vascular mechanisms in dementia with special reference to folate and fibrinolysis". Doctoral thesis, Örebro universitet, Hälsoakademin, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7785.
Pełny tekst źródłaNishio, Keiko. "A mouse model characterizing features of vascular dementia with hippocampal atrophy". Kyoto University, 2011. http://hdl.handle.net/2433/142090.
Pełny tekst źródłaSilva, Magnolia Moreira da. "Associação entre fatores de risco cardiovasculares e demência vascular definitiva". Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/7/7139/tde-05112018-151715/.
Pełny tekst źródłaIntroduction: Previous studies have analyzed the association between cardiovascular risk factors (CVRF) associated with the diagnosis (probable or possible) of vascular dementia (VaD). However, there are no studies that have analyzed the association between CVRF and the occurrence of definitive VaD. The association between CVRF and the occurrence of definite VaD, neuropathologically defined and considered as gold-standard, remains obscure. Objectives: To evaluate the association between CVRF and the occurrence of definitive VaD, pure and mixed. Methods: This is a cross-sectional study which evaluated 707 cases belonging to the Bain Bank of the Brazilian Aging Brain Study Group (BBBABSG) of FMUSP, respecting the inclusion criteria. The history of existence of cardiovascular risk factors in life (hypertension, diabetes mellitus, dyslipidemia, smoking, alcoholism, obesity, and sedentarism) reported by a knowledgeable next-of-kin, with at least weekly contact with the deceased, was associated with the neuropathological diagnosis of vascular dementia reported by a neuropathologist after the autopsy exam. Logistic regression models (with and without adjustment for sex, age and race) were tested to show the association between CVRF and the diagnosis of VaD, pure Vad and mixed VaD. It was also tested the predictive capacity of the factors that proved to be predictors of VaD through the ROC Curve. Results: Sedentary lifestyle was an independent predictor of VaD (OR 1,943, CI 95% 1,198 - 3,151, p = 0.007) and of Pure VaD (OR 3,148, 95% CI, 1.428 - 6.941, p = 0.004). Hypertension was an independent predictor of Mixed VaD (OR 2,240, 95% CI 1,216 - 4,126, p = 0.01). Sedentary lifestyle did not present good predictive capacity for VaD and Pure VaD (AUC = 0.380 and 0.337, respectively), as Hypertension for Mixed DV did not either (AUC = 0.459). Conclusions: Among the CVRF, sedentarism and hypertension were those associated with an increase VaD risk.
Kitamura, Akihiro. "Selective white matter abnormalities in a novel rat model of vascular dementia". Kyoto University, 2012. http://hdl.handle.net/2433/157460.
Pełny tekst źródłaFahlander, Kjell. "Cognitive functioning in aging and dementia : the role of psychiatric and somatic factors /". Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-246-9.
Pełny tekst źródłaLiu, Junguang. "Development of an evidence-based Chinese herbal medicine for the management of vascular dementia". Thesis, View thesis, 2008. http://handle.uws.edu.au:8081/1959.7/33046.
Pełny tekst źródłaLiu, Junguang. "Development of an evidence-based Chinese herbal medicine for the management of vascular dementia". View thesis, 2008. http://handle.uws.edu.au:8081/1959.7/33046.
Pełny tekst źródłaA thesis presented to the University of Western Sydney, College of Health and Science, Centre for Complementary Medicine, in fulfilment of the requirements for the degree of Doctor of Philosophy. Includes bibliographies.
Yamamoto, Yumi. "Characterization of the neurovascular pathology in CADASIL : a model for subcortical vascular dementia". Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1282.
Pełny tekst źródłaAshby, Emma Louise. "Involvement of the kallikrein-kinin system in Alzheimers disease and vascular dementia". Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535229.
Pełny tekst źródłaPantel, Johannes, Johannes Schröder, Marco Essig, Marek Jauss, G. Schneider, Katrin Eysenbach, Rüdiger von Kummer, Klaus Baudendistel, Lothar R. Schad i Michael V. Knopp. "In vivo Quantification of Brain Volumes in Subcortical Vascular Dementia and Alzheimer’s Disease". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135848.
Pełny tekst źródłaDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich
Pantel, Johannes, Johannes Schröder, Marco Essig, Marek Jauss, G. Schneider, Katrin Eysenbach, Rüdiger von Kummer, Klaus Baudendistel, Lothar R. Schad i Michael V. Knopp. "In vivo Quantification of Brain Volumes in Subcortical Vascular Dementia and Alzheimer’s Disease". Karger, 1998. https://tud.qucosa.de/id/qucosa%3A27682.
Pełny tekst źródłaDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Poljak, Anne Medical Sciences Faculty of Medicine UNSW. "Oxidative, inflammatory and vascular factors in Alzheimer's disease". Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/41273.
Pełny tekst źródłaAmar, Khaled. "White matter low attenuation in patients with cognitive impairment : a memory clinic population". Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324234.
Pełny tekst źródłaHung, Ka-lok Victor. "The role of astrocytic endothelin-1 in dementia associated with Alzheimer's disease and mild ischemic stroke". Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B42181987.
Pełny tekst źródłaHarris, Rebekah Lynn Guarnaccia Charles Anthony. "Neurocognitive implications of diabetes on dementia as measured by an extensive neuropsychological battery". [Denton, Tex.] : University of North Texas, 2008. http://digital.library.unt.edu/permalink/meta-dc-9774.
Pełny tekst źródłaVoss, Sarah. "Cognitive deficits in dementia : evaluation and application of a neuropsychological test battery in the differential diagnosis of Alzheimer's disease and vascular dementia". Thesis, University of Bristol, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289560.
Pełny tekst źródłaDynan, Kevin B. "A study of recently proposed cardiovascular risk factors in Alzheimer's disease and vascular dementia". Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322645.
Pełny tekst źródłaHampstead, Benjamin M. Chute Douglas L. "Dissociation of vascular dementia and Alzheimer's disease using a sequential working memory and recognition task /". Philadelphia, Pa. : Drexel University, 2006. http://dspace.library.drexel.edu/handle/1860%20/876.
Pełny tekst źródłaCornett, Patricia F. Hall James. "Factors of the geriatric depression scale that may distinguish between four cognitive diagnostic groups normal, mild cognitive impairment, dementia of the Alzheimer's type, and vascular dementia /". [Denton, Tex.] : University of North Texas, 2009. http://digital.library.unt.edu/ark:/67531/metadc12105.
Pełny tekst źródłaMcCullagh, C. D. "An investigation of inflammatory and vascular genetic risk factors for stroke and dementia following stroke". Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403191.
Pełny tekst źródłaHelman, Alex Marian. "VASCULAR COGNITIVE IMPAIRMENT AND DEMENTIA: THE IMPORTANCE OF MIXED PATHOLOGIES FROM MOUSE MODELS TO HUMANS". UKnowledge, 2018. https://uknowledge.uky.edu/biochem_etds/38.
Pełny tekst źródłaÁvila, Funes José Alberto. "Fragilité et cognition chez le sujet âgé : approche épidémiologique". Thesis, Bordeaux 2, 2012. http://www.theses.fr/2012BOR21964/document.
Pełny tekst źródła“Frailty” is a clinical syndrome characterized by physiological loss of reserves and resilience and represents the summatory action of age, disease and living environment. This geriatric syndrome increases the vulnerability of elderly persons and their risk of disability, falls, hospitalization, institutionalization, and mortality. The definition most widely used, the one proposed by Fried and collaborators, only includes physical elements. Nonetheless, the inclusion of other non-physical components, in particular cognitive function is currently debated. Therefore, the aim of this thesis was the study, from an epidemiological point of view, of the association between cognitive function and frailty using the data of two population-based studies, a French cohort and a Mexican one. The results are in favor of the existence of an association between frailty and cognitive impairment. In the first two studies presented in this thesis, an increased risk of incident disability, hospitalization, and death was found. Therefore, including cognitive function in the phenotype of frailty may be relevant since both processes seem to contribute to the development of negative health-related outcomes. However, regarding the risk of dementia, the results of the third study show that only elderly subjects with cognitive impairment have an increased risk of developing dementia irrespective of their frailty status. Nevertheless, if frailty per se may not be a risk factor of dementia, all types confounded, the last study evidences a strong association between frailty and the incidence of vascular dementia. Such results along with previous studies reporting the existence of vascular and cerebrovascular damage in frail elderly lead us to postulate that frailty could be a prodromal state of vascular dementia
DenBesten, Nicholas Paul. "The Influence of Education and Age on Neurocognitive Test Performance in Alzheimer's Disease and Vascular Dementia". Thesis, NSUWorks, 2009. https://nsuworks.nova.edu/cps_stuetd/25.
Pełny tekst źródłaIsraelsson, Larsen Hanna. "Comorbidity and vascular risk factors associated with idiopathic normal pressure hydrocephalus : the INPH-CRasH Study". Doctoral thesis, Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120175.
Pełny tekst źródłaIdiopatisk normaltryckshydrocefalus (INPH, från engelskans ”idiopathic normal pressure hydrocephalus”) är en neurokirurgiskt behandlingsbar demens. Behandlingen är att operera in en shunt som dränerar cerebrospinalvätska från ventriklarna. Det har föreslagits att INPH skulle kunna orsakas av liknande patofysiologiska mekanismer som vid cerebrovaskulär sjukdom, men den vaskulära riskfaktorprofilen hos INPH-patienter har aldrig undersökts i en modern epidemiologisk studie. De kognitiva symtomen vid INPH påminner om symtomen vid depression, men prevalensen av depression hos INPH-patienter är okänd. Få studier undersöker hur shuntning påverkar livskvalitet och ingen studie har undersökt hur komorbiditet påverkar livskvaliteten vid INPH. Syftet med den här avhandlingen var att undersöka den vaskulära riskfaktorprofilen hos INPH-patienter samt att utforska hypotesen att INPH skulle kunna vara en undergrupp till vaskulär demens. Ytterligare ett syfte med avhandlingen var att undersöka hur många INPH-patienter som har depression samt undersöka hur shunting och komorbiditet påverkar livskvalitet vid INPH. I den första kohorten undersöktes kliniska och radiologiska fynd som tydde på INPH hos de patienter som blivit diagnostiserade med en TIA (från engelskans: transient ischemic attack) 2006-2008 på Norrlands Universitetssjukhus i Umeå. I den andra kohorten undersöktes konsekutivt shuntade INPH-patienter 2008-2010 från fem av sex neurokirurgiska kliniker i Sverige. De patienter som inkluderades i studien (n=176, ålder: 60-85 år, ej dementa) jämfördes med köns- och åldersmatchade kontroller från normalpopulationen (n=368, samma inklusionskriterier som för INPH-patienterna). De riskfaktorer som undersöktes var: hypertension, hyperlipidemi, diabetes, fetma, psykosociala faktorer (stress och depression), rökning, alkohol, fysisk aktivitet och diet. Även kardiovaskulära och cerebrovaskulära sjukdomar undersöktes, liksom perifer vaskulär sjukdom samt livskvalitet. Datainsamling skedde genom frågeformulär, kliniska undersökningar, mätningar, EKG och blodprov. I den första kohorten hade 4% av TIA-patienterna kliniskt och radiologiskt verifierad INPH. I den andra kohorten var vaskulära riskfaktorer överrepresenterade hos INPH-patienterna jämfört med iv normalpopulationen. Hyperlipidemi (OR: 2.4, 95%CI: 1.4-4.0), diabetes (OR: 2.2, 95%CI: 1.2-3.9), fetma (OR: 5.4, 95%CI: 2.5-11.8) och psykosociala faktorer (OR: 5.3, 95%CI: 3.2-8.9) var associerade med INPH oberoende av kön, ålder och de andra riskfaktorerna. Hypertension och fysisk inaktivitet var också associerade med INPH, dock inte oberoende av övriga riskfaktorer. Sammanlagd PAR% (från engelskans: population attributable risk %) för de här sex riskfaktorerna var 24%. INPH-patienterna hade depression i högre utsträckning än kontrollerna (46% vs. 13%, p<0.001), och depression var den viktigaste prediktorn för låg livskvalitet. Resultaten tyder på att vaskulär sjukdom och vaskulära riskfaktorer är involverade i den patofysiologiska mekanismen vid INPH. INPH kan vara en undergrupp till vaskulär demens. En fullständig riskfaktoranalys och screening för depression bör ingå i den preoperativa utvärderingen såväl som i forskning på INPH-patienter, och ett mått på livskvalitet bör införas. Effekten av riktade insatser mot såväl vaskulära riskfaktorer som depression vid INPH bör utvärderas.
Cornett, Patricia F. "Factors of the Geriatric Depression Scale that may Distinguish between Four Cognitive Diagnostic Groups: Normal, Mild Cognitive Impairment, Dementia of the Alzheimer's Type, and Vascular Dementia". Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc12105/.
Pełny tekst źródłaHung, Ka-lok Victor, i 洪家樂. "The role of astrocytic endothelin-1 in dementia associated with Alzheimer's disease and mild ischemic stroke". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B42181987.
Pełny tekst źródłaHarris, Rebekah Lynn. "Neurocognitive implications of diabetes on dementia as measured by an extensive neuropsychological battery". Thesis, University of North Texas, 2008. https://digital.library.unt.edu/ark:/67531/metadc9774/.
Pełny tekst źródłaFreitas, Maria Isabel d'Avila. "Habilidades linguísticas de pacientes com demência vascular: estudo comparativo com a doença de Alzheimer". Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-27092010-140422/.
Pełny tekst źródłaINTRODUCTION: Dementia gradually affects all cognitive and behavioral domains. A progressive deterioration in language is also observed, and may be used as an important measure in the differential diagnosis. Little is known about the language pattern in Vascular Dementia (VaD). The few existing studies have addressed specific aspects of language and produced conflicting results. The Arizona Battery of Communication Disorders in Dementia (ABCD) was designed to identify and evaluate functional communication disorders and other abilities as episodic memory and visuospatial construction in dementia. The lack of studies using the ABCD in patients with VaD, and the need to expand the Brazilian experience in the use of this battery in patients with Alzheimer\'s Disease (AD), were the aspects that motivated this study. OBJECTIVES: To describe the linguistic abilities in mild VaD patients compared to AD patients and cognitively normal elderly. METHODS: We evaluated 23 mild VaD patients - VaDG (mean age: 71,7(6,9) and schooling: 9,1(5)), 20 mild AD patients - ADG (mean age: 77,3(3,9) and schooling: 6,7(4,3)) and 31 controls - CG (mean age: 72,7(6,9) and schooling: 9,0(4,4)) using the ABCD and tests to evaluate cognitive functions supporting language. RESULTS: There were statistically differences significant between VaDG and CG in all ABCD measures, except for the subtest Comparative Question from Linguistic Comprehension Construct. The accuracy of the ABCD was above 80% to discriminate VaDG and CG in all constructs. Comparison between VaDG and ADG showed statistically differences significant in two constructs of ABCD: in the Episodic Memory Construct, and in the Linguistic Expression Construct (Confrontation Naming subtest). CONCLUSIONS: Linguistic abilities of mild VaD patients were impaired in all measures of the Linguistic Expression and Linguistic Comprehension Constructs, except for the Comparative Questions subtest. Linguistic differences between mild VaD patients and mild AD patients were observed only in the Confrontation Naming subtest of ABCD
Al-Janabi, Omar M. "CEREBROVASCULAR RISK FACTORS, ARTERIOLAR SCLEROSIS, AND COGNITIVE DECLINE IN THE KENTUCKY APPALACHIAN “STROKE-BELT”". UKnowledge, 2016. http://uknowledge.uky.edu/medsci_etds/5.
Pełny tekst źródłaGueniot, Florian. "Contribution de la voie Wnt dans la stabilité de la barrière hémato-encéphalique". Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0386.
Pełny tekst źródłaDementia is characterized by a progressive deterioration of mental capacity that inevitably compromises independent living. Advancing age is the main risk factor, and due to the aging of the world population and lack of effective treatments, the number of affected individuals, estimated at 50 million worldwide, is anticipated to triple by 2050 at a cost approaching 4 trillion dollars. Recent studies tend to show a crucial role of vascular dysfunction in dementia pathologies. Indeed, a large autopsy-based neuropathological study has revealed that 80% of patients diagnosed with Alzheimer’s disease (AD) exhibit vascular pathology. However, the cellular and molecular mechanisms underlying vascular dysfunction and alteration of the blood brain barrier (BBB) integrity associated with dementia and AD remain to be elucidated. Body of evidences point out the Wnt pathway role in the maintenance of BBB integrity. The laboratory recently identified an E3-ubiquitin-ligase, PDZRN3 acting like Wnt non-canonical pathway modulator in endothelial cells repressing canonical Wnt pathway. This ubiquitin-ligase is involved in vascular permeability, making it a promising modulatory target to act upon alterations of the BBB integrity. We then hypothesized that: BBB is destabilized in the early onset of dementia & AD, keeping EC in a differentiated “barrier” state through Wnt signaling modulation should modulates early onset of dementia. We have generated Pdzrn3 inducible EC knockout (iECKO) mice and submitted them to gradual cerebral hypoperfusion by implanting ameroïd constrictors on both common carotid arteries. While memory performance of wild-type littermates is impaired under hypoperfusion, that of iECKO mice is preserved. Importantly, our data show that iECKO mice exhibit a significant decrease in the number of brain lesions (microinfarctions) as well as reduced neuronal loss in the CA1 hippocampal region known to play a crucial role in spatial recognition memory. Conversely, endothelial PDZRN3 overexpression (iECOE) produces phenotypes opposite to those of Pdzrn3-deleted mice (iECKO) with a clear deterioration of memory function associated with increased BBB leakage, brain lesions, hippocampal neuronal loss and inflammation compared to controls. We also wanted to investigate the impact of endothelial deletion of Pdzrn3 in AD. To this end, we have generated and validated a dedicated triple transgenic mouse model by crossing APP/PS1, AD mouse model with with Pdzrn3 iECKO mice to generate APP/PS1;Pdzrn3 iECKO colonies. Strikingly, our findings point to a significant decrease of Aβ-deposits at 6 months in APP/PS1;Pdzrn3 iECKO compared to APP/PS1 littermate control mice. At 8 months, APP/PS1 littermate controls appears severely impaired in a spatial recognition memory paradigm whereas APP/PS1;Pdzrn3 iECKO performed as well as non-demented age-matched Pdzrn3 iECKO and littermate controls
Anastácio, Janine Beatriz Ramos. "Efeito neuroprotetor do resveratrol no modelo de demência por hipoperfusão encefálica crônica em ratos". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/77994.
Pełny tekst źródłaChronic cerebral hypoperfusion (CCH) is an important risk factor for cognitive decline and other brain dysfunctions, such as Alzheimer’s Disease and Vascular Dementia. The aim of the present study was to investigate the neuroprotective effect of Resveratrol (RSV) on behavioral, biochemical and morphological parameters in an experimental model of Vascular Dementia. Adult Wistar rats were submitted to the CCH modified model by means of permanent 2-vessel occlusion (2VO) and daily treatment, initiated one hour after permanent vessel occlusion, with intraperitoneal injections (20 mg/kg) of RSV for 7 days. Behavioral testing was performed between the 35th and the 45th day after 2VO surgery in the Morris Water Maze task, allowing for the evaluation of spatial memory function. At the end of the behavioral assessment, half of the animals were transcardially perfused for histological analysis and the remaining were euthanized in 3 times (3. 14 and 45 days after ischemic injury) for NGF expression evaluation (neural growth factor). Results demonstrate that the treatment with RSV significantly attenuated pyramidal cell death in CA1 hippocampal field and prevented spatial memory impairment. The increase of NGF expression was evidenced on the 3rd day after CCH induction in all ischemic animals and on the 45th day after CCH induction in animals treated with RSV. On the basis of these data, we hypothesize that the long term increase in NGF expression in the hippocampus after CCH may characterize one pathway involved in the neuroprotective mechanisms of RSV.
Schmid, Benedikt [Verfasser], i Wolfgang [Akademischer Betreuer] Müllges. "Relation between cerebral arterio-venous transit time and neuropsychological performance in patients with vascular dementia / Benedikt Schmid. Betreuer: Wolfgang Müllges". Würzburg : Universität Würzburg, 2013. http://d-nb.info/1102820040/34.
Pełny tekst źródłaMatioli, Maria Niures Pimentel dos Santos. ""Estudo comparativo do desempenho em testes neuropsicológicos de pacientes com diagnóstico de doença de Alzheimer e demência vascular"". Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-01022006-212034/.
Pełny tekst źródłaAlzheimers disease (AD) and vascular dementia (VaD), especially its subcortical form, are responsible for the majority of dementia cases in the elderly and are not always easily differentiated from a clinical point of view. The aim of this study was to compare the performance of mild VaD and AD patients in a series of brief cognitive tests (Mini-mental State Examination and Neuropsi battery, in order to confirm the diagnosis of dementia; CLOX 1 and 2, category and letter fluency, a delayed recall test of 10 simple figures and the EXIT 25), and to evaluate the potential use of these tests for the differential diagnosis between them. The performance of the VaD group was significantly impaired, in relation to the AD group, in the tests CLOX 2, category verbal fluency and letter verbal fluency, while the AD patients performed significantly worst in the delayed recall test.
Behensky, Adam Alexander. "Sigma Receptor Activation Mitigates Toxicity Evoked by the Convergence of Ischemia, Acidosis and Amyloid-beta". Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5641.
Pełny tekst źródłaBaptista, Miguel José de Carvalho Viana. "Alterações da substância branca cerebral relacionadas com o envelhecimento". Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2009. http://hdl.handle.net/10362/5194.
Pełny tekst źródłaYasuda, Ken. "Effect of fingolimod on oligodendrocyte maturation under prolonged cerebral hypoperfusion". Kyoto University, 2020. http://hdl.handle.net/2433/253172.
Pełny tekst źródłaMcDonald, Alexa. "Assessing the robustness of the Test of Premorbid Functioning (TOPF) as a measure of premorbid intelligence in Alzheimer's and vascular dementia, and clinical research portfolio". Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6793/.
Pełny tekst źródłaBarei, Moniri Lenoir Hermine. "Relations entre dépression, symptômes dépressifs et démences chez le sujet âgé : rôle de la pression artérielle". Thesis, Paris 11, 2012. http://www.theses.fr/2012PA11T035/document.
Pełny tekst źródłaDepression is highly common throughout the life course and dementia is common in late life. Depression has been linked with dementia, yet the direction and pathological mechanisms of this association (whether depression is a prodromal feature or consequence of, or a risk factor for dementia) remains unclear. Vascular risk factors are associated to the risk of incident cognitive impairment and dementia and comorbid vascular disease is a feature of depression in latelife. Therefore, the hypothesis that vascular risk factors are the ultim denominator of psychological perturbations and dementia is to be verified. The aim of this work was to study the links between blood pressure, depression and dementia. In a cohort of 9294 community-dwelling elderly individuals aged 65 years and over, participating to the longitudinal population-based 3 City Study, followed up for 4 years, we found an association between baseline depressive symptoms’ severity and the incident dementia risk (particularly of vascular type). Conversely, we found no association between history of depression and incident dementia. Moreover, our cross sectional analyses exhibited an inverse association between systolic and diastolic blood pressure values and depression. Overall, however, the association between depressive symptoms and dementia was not mediated by hypertension. These results indicate that depression is rather a prodromal symptom of vascular dementia than a risk factor for it. The explanation for the inverse association found between blood pressure values and depression is not straightforward. Low blood pressure may lead to cerebral hypoperfusion found to be associated with white matter lesions in cerebral regions vulnerable to alterations of cerebral blood flow, and associated with cognitive impairment and depression. This work offers the opportunity for the definition of group of populations at high risk to develop dementia, vascular one in particular. It also gives the perspective of research on the biological mechanisms linking blood pressure and depression. From a methodological point of view, it emphasizes the need for instruments assessing precisely and thoroughly these two conditions which influence the assessment of each other
Örulv, Linda. "Fragile identities, patched-up worlds : Dementia and meaning-making in social interaction". Doctoral thesis, Linköpings universitet, Hälsa och samhälle, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11736.
Pełny tekst źródłaThis thesis focuses on the identity work and the meaning- or sense-making that continue in the face of evolving dementia diseases, in social interaction, and the challenges for care this involves. The study adopts an actor-oriented approach and addresses the question of how persons with age-related progressive dementia diseases in everyday communication make sense of their situations, their surroundings, and their lives – all within the context of daily life in residential care. Of particular interest is how these persons handle issues of joint action in a shared world and how they establish and maintain an identity in the inte-raction. This is in spite of severe memory problems, disorientation in time and space, dif-fering understandings of the current situation, and difficulties in telling “accurate” and temporally ordered stories about their lives. The thesis also addresses the question of how caregivers may handle the complex interplay between residents in daily care, in maintain-ing and respecting these persons’ dignity. The study follows a growing tradition of studying interaction in dementia as mean-ing-based and situated in a context rather than merely as behavior caused by cognitive impairment. Methodologically, this is an ethnographic study based on observations made within a period of six months. The data consist of around 150 hours of video recordings and complementary field notes. This extensive material has made it possible to study the social interaction both in detail and situated in a larger context. The findings point to remaining competences and strategies that persons with demen-tia use actively and creatively in the ongoing interaction – and, given the premises, often in a rational way. This is discussed in terms of resources for dementia care, in relation to the great challenge of patching up and putting together a comprehensive socially shared world as well as maintaining continuity with the persons’ previous life histories in a way that preserves a positive self-identity.
Matioli, Maria Niures Pimentel dos Santos. "Associação entre diabetes mellitus e demência: estudo neuropatológico". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-18112016-111336/.
Pełny tekst źródłaThe scientific literature has been debating the existence of an association between diabetes mellitus (DM) and dementia, Alzheimer\'s disease (AD) and vascular dementia (VaD). DM is a known risk factor for cerebrovascular disease (CVD) and VaD, but there is still no consensus on the real role of DM in the development of AD neuropathology. Objectives: to investigate the association among DM and dementia, neuropathology (NP) of AD and VaD. Methods: Data were collected from the cases included in the Brain Bank of the Brazilian Aging Brain Study Group between 2004 and 2015. Cases were divided into 2 groups: no diabetics and diabetics. Clinical diagnosis of dementia was determined by the scores >= 1.0 in the Clinical Dementia Rating (CDR) and >= 3.42 in the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Etiological diagnoses of dementia were determined by neuropathological examination, using immunohistochemistry. The proportion of dementia cases, AD and VaD of no diabetics and diabetics were investigated as well as the relationship among DM and neuritic plaques (NPq) and neurofibrillary tangles (NFT). Mann-Whitney test and multiple linear regression for quantitative variables, and chi-square test and multiple logistic regression for categorical variables were the statistical analyses applied. Results: Total sample included 1037 subjects, divided in 758 (73.1%) no diabetics and 279 diabetics (26.9%). Dementia was present in 27.8% of diabetics. DM did not increase the frequency for dementia (OR: 1.22; IC 95%: 0.81-1.82; p=0.34). DM was not associated with NFT (p=0.81), NPq (p=0.31), infarct group (0.94), cerebral amyloid angiopathy (0.42) and hyaline arteriolosclerosis (p=0.07). After adjustment for demographic variables and vascular risk factors, DM was not associated with DA and vascular NP. Conclusion: DM is not associated with dementia, AD and vascular neuropathology