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Artykuły w czasopismach na temat „De novo acute respiratory failure”

Autor: Grafiati

Data publikacji: 21 września 2024

Data aktualizacji: 31 lipca 2025

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1

Petitjeans, Fabrice, and Luc Quintin. "Noninvasive Failure in De Novo Acute Hypoxemic Respiratory Failure." Critical Care Medicine 44, no. 11 (2016): e1153-e1154. http://dx.doi.org/10.1097/ccm.0000000000001967.

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Carteaux, Guillaume, Teresa Millán-Guilarte, Nicolas De Prost, et al. "Failure of Noninvasive Ventilation for De Novo Acute Hypoxemic Respiratory Failure." Critical Care Medicine 44, no. 2 (2016): 282–90. http://dx.doi.org/10.1097/ccm.0000000000001379.

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García-de-Acilu, Marina, Bhakti K. Patel, and Oriol Roca. "Noninvasive approach for de novo acute hypoxemic respiratory failure." Current Opinion in Critical Care 25, no. 1 (2019): 54–62. http://dx.doi.org/10.1097/mcc.0000000000000570.

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Costa, Bárbara. "Ventilação Não-Invasiva na Falência Respiratória Aguda." Medicina Interna 28, no. 2 (2021): 133–39. http://dx.doi.org/10.24950/o/320/20/2/2021.

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Introdução: A ventilação não invasiva (VNI) é uma opção válida, ainda que não consensual, no tratamento de doentes com falência respiratória aguda. O presente artigo tem o objetivo de identificar fatores preditores de resposta à VNI neste grupo de doentes. Métodos: Estudo retrospectivo longitudinal que incluiu todos os doentes admitidos numa unidade de cuidados intensivos nos anos 2016 e 2017, nos quais a VNI foi utilizada no decurso de falência respiratória aguda de novo (PaO2/ FiO2 < 200). Foram incluídos doentes com pneumonia adquirida na comunidade (PAC) e síndrome da dificuldade respir

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Park, Sunghoon. "Treatment of acute respiratory failure: noninvasive mechanical ventilation." Journal of the Korean Medical Association 65, no. 3 (2022): 144–50. http://dx.doi.org/10.5124/jkma.2022.65.3.144.

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Background: Noninvasive ventilation (NIV) has been an important strategy to support patients with respiratory failure, while preventing complications assorted with invasive mechanical ventilation. Physicians need to be aware of the various roles of NIV and the challenges encountered in clinical practice.Current Concepts: Traditionally, the application of NIV has been well-known to be associated with reduced mortality in patients with chronic obstructive pulmonary disease (COPD) or acute pulmonary edema and those suffering from acute respiratory failure. However, despite some positive results o

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Zayed, Yazan, Mahmoud Barbarawi, Babikir Kheiri, et al. "Initial Noninvasive Oxygenation Strategies in Subjects With De Novo Acute Hypoxemic Respiratory Failure." Respiratory Care 64, no. 11 (2019): 1433–44. http://dx.doi.org/10.4187/respcare.06981.

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Martin-Agba, John Chukwuma, Elohor Omoefe Okoro, Owora Amadi, and Kene Maduemem. "De novo LMNA mutation in a migrant child presenting with respiratory failure." BMJ Case Reports 18, no. 4 (2025): e265340. https://doi.org/10.1136/bcr-2025-265340.

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We report a case of an unconscious Black African male child who recently migrated from a West African country. He has a background of undiagnosed muscular dystrophy, regression of gross motor skills from early childhood and GMCFS (Gross Motor Function Classification System) Level V. This child had developed respiratory failure following an acute febrile illness and altered sensorium. This resulted in a cascade of events to manage the index presentation while unravelling the previously undiagnosed pathology. Genetic testing revealed pathogenic LMNA missense variant (NM_170707.2:c.1072G>A p.G

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Spicuzza, Lucia, and Matteo Schisano. "High-flow nasal cannula oxygen therapy as an emerging option for respiratory failure: the present and the future." Therapeutic Advances in Chronic Disease 11 (January 2020): 204062232092010. http://dx.doi.org/10.1177/2040622320920106.

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Conventional oxygen therapy (COT) and noninvasive ventilation (NIV) have been considered for decades as frontline treatment for acute or chronic respiratory failure. However, COT can be insufficient in severe hypoxaemia whereas NIV, although highly effective, is poorly tolerated by patients and its use requires a specific expertise. High-flow nasal cannula (HFNC) is an emerging technique, designed to provide oxygen at high flows with an optimal degree of heat and humidification, which is well tolerated and easy to use in all clinical settings. Physiologically, HFNC reduces the anatomical dead

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Lindstedt, Sandra, Edgar Grins, Hillevi Larsson, et al. "Lung transplant after 6 months on ECMO support for SARS-CoV-2-induced ARDS complicated by severe antibody-mediated rejection." BMJ Open Respiratory Research 8, no. 1 (2021): e001036. http://dx.doi.org/10.1136/bmjresp-2021-001036.

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There have been a few reports of successful lung transplantation (LTx) in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS); however, all reports were with rather short follow-up. Here we present a 62-year-old man without prior lung diseases. Following SARS-CoV-2-induced ARDS and 6 months of extracorporeal membrane oxygenation, he underwent LTx. 3 months post-transplantation he developed acute hypoxia requiring emergency intubation. Chest imaging showed acute rejection, and de novo DQ8-DSA was discovered. He was treated with a high dose of corticosteroids and plasmaph

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Coudroy, Rémi, Jean-Pierre Frat, Stephan Ehrmann, et al. "High-flow nasal oxygen therapy alone or with non-invasive ventilation in immunocompromised patients admitted to ICU for acute hypoxemic respiratory failure: the randomised multicentre controlled FLORALI-IM protocol." BMJ Open 9, no. 8 (2019): e029798. http://dx.doi.org/10.1136/bmjopen-2019-029798.

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IntroductionNon-invasive ventilation (NIV) is recommended as first-line therapy in respiratory failure of critically ill immunocompromised patients as it can decrease intubation and mortality rates as compared with standard oxygen. However, its recommendation is only conditional. Indeed, the use of NIV in this setting has been challenged recently based on results of trials finding similar outcomes with or without NIV or even deleterious effects of NIV. To date, NIV has been compared with standard oxygen but not to high-flow nasal oxygen therapy (HFOT) in immunocompromised patients. Several stu

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Boulos, Peter K., Scott V. Freeman, Timothy D. Henry, Ehtisham Mahmud, and John C. Messenger. "Interaction of COVID-19 With Common Cardiovascular Disorders." Circulation Research 132, no. 10 (2023): 1259–71. http://dx.doi.org/10.1161/circresaha.122.321952.

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The onset and widespread dissemination of the severe acute respiratory syndrome coronavirus-2 in late 2019 impacted the world in a way not seen since the 1918 H1N1 pandemic, colloquially known as the Spanish Flu. Much like the Spanish Flu, which was observed to disproportionately impact young adults, it became clear in the early days of the coronavirus disease 2019 (COVID-19) pandemic that certain groups appeared to be at higher risk for severe illness once infected. One such group that immediately came to the forefront and garnered international attention was patients with preexisting cardiov

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Maquet, Emilie, Sabine Costagliola, Jasmine Parma, et al. "Lethal Respiratory Failure and Mild Primary Hypothyroidism in a Term Girl with a de Novo Heterozygous Mutation in the TITF1/NKX2.1 Gene." Journal of Clinical Endocrinology & Metabolism 94, no. 1 (2009): 197–203. http://dx.doi.org/10.1210/jc.2008-1402.

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Abstract Context: Thyroid transcription factor 1 (TITF1/NKX2.1) is expressed in the thyroid, lung, ventral forebrain, and pituitary. In the lung, TITF1/NKX2.1 activates the expression of genes critical for lung development and function. Titf/Nkx2.1−/− mice have pituitary and thyroid aplasia but also impairment of pulmonary branching. Humans with heterozygous TITF1/NKX2.1 mutations present with various combinations of primary hypothyroidism, respiratory distress, and neurological disorders. Objective: The objective of the study was to report clinical and molecular studies of the first patient w

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Peigh, Graham, Marysa V. Leya, Jayson R. Baman, Eric P. Cantey, Bradley P. Knight, and James D. Flaherty. "Novel coronavirus 19 (COVID-19) associated sinus node dysfunction: a case series." European Heart Journal - Case Reports 4, FI1 (2020): 1–6. http://dx.doi.org/10.1093/ehjcr/ytaa132.

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Abstract Background Novel coronavirus-19 disease (COVID-19) is associated with significant cardiovascular morbidity and mortality. To date, there have not been reports of sinus node dysfunction (SND) associated with COVID-19. This case series describes clinical characteristics, potential mechanisms, and short-term outcomes of COVID-19 patients who experience de novo SND. Case summary We present two cases of new-onset SND in patients recently diagnosed with COVID-19. Patient 1 is a 70-year-old female with no major past medical history who was intubated for acute hypoxic respiratory failure seco

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14

Novikova, A. A., G. A. Klyasova, E. O. Gribanova, V. A. Okhmat, V. V. Ryzhko, and V. G. Savchenko. "Infectious complications in patients with multiple myeloma on first chemotherapy cycle." Oncohematology 13, no. 3 (2018): 63–75. http://dx.doi.org/10.17650/1818-8346-2018-13-3-63-75.

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The aim of the study was to evaluate the profile and risk factors for acquisition of infections in patients with de novo multiple myeloma (MM) on the 1st chemotherapy cycle (CC).Materials and methods. Study included patients with de novo MM undergoing chemotherapy from January 2013 till November 2017 in National Research Center for Hematology, Russia.Results. A total of 156 patients with de novo MM (median age 61 years) were included in the study. Follow-up period was 21–82 days (median 26 days), first CC contained bоrtezomib. Infections occurred in 77 (49.4 %) of patients with MM, from them 2

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Mistrulli, Raffaella, Armando Ferrera, Melwyn Luis Muthukkattil, Massimo Volpe, Emanuele Barbato, and Allegra Battistoni. "SARS-CoV-2 Related Myocarditis: What We Know So Far." Journal of Clinical Medicine 12, no. 14 (2023): 4700. http://dx.doi.org/10.3390/jcm12144700.

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A minority of patients with severe acute respiratory syndrome coronavirus 2 (COVID-19) develop cardiovascular complications, such as acute cardiac lesions with elevated troponins, de novo systolic heart failure, pericardial effusion and, rarely, acute myocarditis. The prevalence of COVID-19-related myocarditis ranges from 10 to 105 cases per 100,000 COVID-19-infected individuals, with a male predominance (58%) and a median age of 50 years. The etiopathogenetic mechanism is currently unclear, but may involve direct virus-mediated damage or an exaggerated immune response to the virus. Mortality

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Ilieva, V., T. Mihalova, Yo Yamakova, R. Petkov, and B. Velev. "Cost-Minimization Analysis of Non-Invasive and Invasive Mechanical Ventilation for De Novo Acute Hypoxemic Respiratory Failure in an Eastern European Setting." Acta Medica Bulgarica 46, no. 1 (2019): 17–20. http://dx.doi.org/10.2478/amb-2019-0003.

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Abstract Introduction: In the light of constant pressure for minimizing healthcare costs we made a cost-minimization analysis comparing invasive mechanical ventilation (IMV) and non-invasive ventilation (NIV) as treatment for hypoxemic acute respiratory failure (ARF). Aim: The primary objective was to estimate the direct medical costs generated by a patient on IMV and NIV. A secondary objective was to identify which aspect of the treatment was most expensive. Material and Methods: This is a single center retrospective study including 36 patients on mechanical ventilation due to hypoxemic ARF,

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Schellongowski, Peter, Thomas Staudinger, Klaus Laczika, et al. "Prognostic Factors Predicting Survival in De Novo AML Patients Requiring Intensive Care." Blood 110, no. 11 (2007): 2860. http://dx.doi.org/10.1182/blood.v110.11.2860.2860.

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Abstract Acute myeloid leukemia (AML) is an acute life-threatening disease with variable clinical presentation. In this study, the percentage of patients (pts) with de novo AML requiring intensive care prior or during induction chemotherapy (ICT), as well as prognostic factors predicting survival in these pts were analyzed. A total of 471 consecutive pts (median age 62 years; range: 16–92) seen at the Vienna University Hospital between 1994–2006 were enrolled. In pts requiring critical care, simplified acute physiology score (SAPS) II as well as the need for invasive mechanical ventilation (IM

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Lodhi, F. A. K., T. Akcan, J. N. Mojarrab, S. Sajjad, and R. Blonsky. "A Case of De Novo Antiglomerular Basement Membrane Disease Presenting during Pregnancy." Case Reports in Nephrology 2021 (March 17, 2021): 1–5. http://dx.doi.org/10.1155/2021/5539205.

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Background. Acute kidney injury (AKI) requiring dialysis during pregnancy is uncommon. We present a case of a young female diagnosed with antiglomerular basement membrane (anti-GBM) disease during pregnancy. Case Presentation. A 23-year-old woman approximately 15 weeks pregnant experienced weakness, nausea, vomiting, and anorexia for one week and anuria for 48 hours. No known drug allergies and no significant social or family history for kidney or genitourinary disease were reported. Laboratory analysis revealed anemia, life-threatening hyperkalemia, AKI, and elevated antiglomerular basement m

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Gaddam, Mrunanjali, Samridhi Sinha, Rabia Iqbal, et al. "Factors Affecting the in-Hospital Mortality in Patients with Diffuse Large B-Cell Lymphoma: A National Inpatient Sample Study (2018-2020)." Blood 144, Supplement 1 (2024): 1705. https://doi.org/10.1182/blood-2024-211933.

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Introduction: Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma and is the most common non-Hodgkin's lymphoma arising from mature B cells. It can occur either de novo by BCL6 rearrangement or by the transformation of many different types of low-grade lymphomas, including follicular lymphoma, marginal zone lymphoma, lymphoplasmacytic lymphoma and chronic lymphocytic leukemia (Richter's transformation). Patients often present with a rapidly growing symptomatic mass in nodal or extranodal tissues such as the stomach, gastrointestinal tract or lungs, central nervous system, or other

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Pandor, Abdullah, Praveen Thokala, Steve Goodacre, et al. "Pre-hospital non-invasive ventilation for acute respiratory failure: a systematic review and cost-effectiveness evaluation." Health Technology Assessment 19, no. 42 (2015): 1–102. http://dx.doi.org/10.3310/hta19420.

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BackgroundNon-invasive ventilation (NIV), in the form of continuous positive airway pressure (CPAP) or bilevel inspiratory positive airway pressure (BiPAP), is used in hospital to treat patients with acute respiratory failure. Pre-hospital NIV may be more effective than in-hospital NIV but requires additional ambulance service resources.ObjectivesWe aimed to determine the clinical effectiveness and cost-effectiveness of pre-hospital NIV compared with usual care for adults presenting to the emergency services with acute respiratory failure and to identify priorities for future research.Data sou

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Bzdęga, Katarzyna, Anna Kutkowska-Kaźmierczak, Gail H. Deutsch, et al. "Prenatal Detection of a FOXF1 Deletion in a Fetus with ACDMPV and Hydronephrosis." Genes 14, no. 3 (2023): 563. http://dx.doi.org/10.3390/genes14030563.

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Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a lethal lung developmental disorder caused by the arrest of fetal lung formation, resulting in neonatal death due to acute respiratory failure and pulmonary arterial hypertension. Heterozygous single-nucleotide variants or copy-number variant (CNV) deletions involving the FOXF1 gene and/or its lung-specific enhancer are found in the vast majority of ACDMPV patients. ACDMPV is often accompanied by extrapulmonary malformations, including the gastrointestinal, cardiac, or genitourinary systems. Thus far, most of the de

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Ghosh, Samit, Frances Weidert, Bethany Flage, Prithu Sundd, and Solomon F. Ofori-Acquah. "A Novel Role for P-Selectin in the Pathogenesis of Acute Chest Syndrome." Blood 128, no. 22 (2016): 157. http://dx.doi.org/10.1182/blood.v128.22.157.157.

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Abstract Acute chest syndrome (ACS) is a potentially fatal lung complication of sickle cell disease (SCD). There are currently no mechanistic based therapies for ACS and it continues to be a leading cause of death in SCD. Recent studies have identified independent links between extracellular heme with ACS, and with vaso-occlusive crisis (VOC) a common prodrome of ACS. Our experimental ACS model involves intravenous injection of purified hemin typically 35 µmoles/kg, which raises total plasma heme to a clinically relevant pathophysiologic level equivalent to ~0.5g/dl of hemoglobin, and causes r

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Salazar Lozano, Hugo Esteban, Ana Karina Pérez León, María Daniela Pérez León, Andrea Carolina Pérez León, and Diego Fernando Atapuma Madrid. "Rett syndrome in a pediatric patient: progressive clinical presentation and genetic confirmation via mecp2 mutation." Arandu UTIC 12, no. 2 (2025): 1722–31. https://doi.org/10.69639/arandu.v12i2.1022.

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Rett syndrome (RTT) is a rare X-linked neurodevelopmental disorder characterized by an early phase of apparently normal development, followed by rapid regression in language, motor coordination, and purposeful hand use. We report the case of a female pediatric patient with classic RTT confirmed by a de novo pathogenic mutation in the MECP2 gene. The patient developed typically until 18 months of age, when she began to lose speech, motor function, social interaction, and developed stereotypic hand movements. Initially misdiagnosed with autism spectrum disorder and cerebral palsy, genetic testin

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Bazhenov, Aleksei, Elena N. Parovichnikova, Gennadiy M. Galstyan, Vera V. Troitskaya, Elena O. Gribanova, and Valery G. Savchenko. "Long-Term Outcomes of De Novo Acute Myeloid Leukemia (AML) Patients (pts) with Life Threating Complications." Blood 132, Supplement 1 (2018): 5898. http://dx.doi.org/10.1182/blood-2018-99-116114.

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Abstract Background. Induction of remission in pts with AML is often associated with the life-threating complication and ICU admission. The long-term outcomes of these AML pts discharged from ICU are unknown. The aim was to estimate the long-term outcomes of de novo AML pts required ICU admission due to life-threating complications during induction of remission. Methods. All de novo AML pts, younger than 60 y.o, median age 34 (17-60 yo), from 2013 to 2016 were enrolled in the study. All pts were divided into 2 groups: pts who required ICU admission during induction chemotherapy due to life-thr

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Ocaña-Macchi, Manuela, Michael Bel, Laurence Guzylack-Piriou, et al. "Hemagglutinin-Dependent Tropism of H5N1 Avian Influenza Virus for Human Endothelial Cells." Journal of Virology 83, no. 24 (2009): 12947–55. http://dx.doi.org/10.1128/jvi.00468-09.

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ABSTRACT Although current H5N1 highly pathogenic avian influenza viruses (HPAIV) are inefficiently transmitted to humans, infected individuals can suffer from severe disease, often progressing rapidly to acute respiratory distress syndrome and multiorgan failure. This is in contrast with the situation with human influenza viruses, which in immunocompetent individuals usually cause only a respiratory disease which is less aggressive than that observed with avian H5N1 viruses. While the biological basis of inefficient transmission is well documented, the mechanisms by which the H5N1 viruses caus

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Koga, Yasutaka, Kotaro Kaneda, Nao Fujii, et al. "Association between increased nonaerated lung weight and treatment failure in patients with de novo acute respiratory failure: Difference between high-flow nasal oxygen therapy and noninvasive ventilation in a multicentre retrospective study." Journal of Critical Care 65 (October 2021): 221–25. http://dx.doi.org/10.1016/j.jcrc.2021.06.025.

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Bereda, Gudisa. "COVID-19 increases a person’s risk of cardiovascular problems: how common is chronic heart failure in SARS-CoV-2 patients? a case report." Annals of Medicine & Surgery 85, no. 5 (2023): 2208–11. http://dx.doi.org/10.1097/ms9.0000000000000635.

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Background and importance: The coronavirus disease of 2019 (COVID-19) infection typically affects the lungs but can also cause life-threatening heart issues. Heart failure is a common condition that can occur either with an existing heart condition or de novo as part of the clinical course of COVID-19. Case presentation: On 11 October 2022, a 60-year-old middle-aged black African woman widow was admitted with a history of muscular weakness for 2 days, a lack of appetite, and occasional vomiting for 1 day. She arrived at the emergency room after complaining for 2 days of peeing less than usual,

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Schiller, Gary J., Daniel J. DeAngelo, Arnaud Pigneux, et al. "Phase II Study of VNP40101M (Cloretazine®) in Elderly Patients with De Novo Poor Risk Acute Myelogenous Leukemia (AML)." Blood 110, no. 11 (2007): 917. http://dx.doi.org/10.1182/blood.v110.11.917.917.

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Abstract VNP40101M (Cloretazine®) is a novel sulfonylhydrazine alkylating agent which preferentially targets the O6 position of guanine resulting in DNA cross-links. Data from a previously reported phase II multi-center single agent study (CLI-033) in patients ≥60 years old with newly diagnosed AML or high risk MDS showed an overall response rate of 31% after VNP40101M induction (Giles, 2007). Subgroup analysis showed significant activity in 54 elderly patients with de novo AML with 24 patients (45%) achieving a complete response (CR) or CRp (CI: 30.9;58.6). Subsequently a confirmatory phase I

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Ghosh, Samit, and Solomon F. Ofori-Acquah. "Extracellular Hemin Auto-Amplification Intensifies Tissue Injury In Sickle Cell Disease." Blood 122, no. 21 (2013): 972. http://dx.doi.org/10.1182/blood.v122.21.972.972.

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Abstract Acute organ failure is a major clinical concern in sickle cell disease (SCD). However, the mechanism responsible for this potentially lethal complication is poorly understood. We tested the hypothesis that extracellular hemin liberates an intracellular danger molecule that promotes acute organ failure in SCD. Transgenic homozygous SCD (SS), sickle-trait (AS) and normal human hemoglobin (Hb) AA mice were infused with purified hemin (35 µmoles/kg), which raised total plasma hemin by ∼0.45 mM (equivalent to 0.72 g/dl Hb) within 5 min in all three groups of mice. In agreement with our pre

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Massara, M., L. Zappelli, A. Lanari, et al. "LYME AND DENGUE FEVER: FROM BANGLADESH TO ITALY." European Heart Journal Supplements 26, Supplement_2 (2024): ii59. http://dx.doi.org/10.1093/eurheartjsupp/suae036.134.

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Abstract Background Dengue fever (Flavivirus) and Lyme disease (Borrelia burgdorferi) are rare tropical infectious diseases transmitted by hematophagous vectors (Aedes mosquitoes and ticks, respectively), and they are extremely uncommon in Italy. In European countries, both represent a public health concern as they manifest as imported diseases. Case Report A 54–year–old man from Bangladesh was admitted with symptoms of fever, dyspnea, and pericarditic chest pain. Laboratory and imaging examinations revealed severe acute respiratory failure secondary to left lower lobe pneumonia and pleuroperi

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Jéssica, Gonçalves de Lima, and Felipe Fonseca Reis Luís. "UTILIZAÇÃO DA OXIGENOTERAPIA NASAL DE ALTO FLUXO EM PACIENTES ADULTOS COM INSUFICIÊNCIA RESPIRATÓRIA HIPOXÊMICA: UMA REVISÃO DE LITERATURA." Revistaft 27, no. 127 (2023): 20. https://doi.org/10.5281/zenodo.10052120.

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A Oxigenoterapia Nasal de Alto Fluxo (ONAF) é um tipo de tratamento considerado novo. Essa terapia vem tornando-se comum na UTI a fim de gerenciar pacientes com insuficiência respiratória aguda hipoxêmica. Nesse sentido, muitas são as aplicações desta terapêutica, tais como assegurar a oxigenação durante procedimentos invasivos, por exemplo, na broncoscopia ou no processo de intubação orotraqueal (IOT), no pós extubação, na apneia do sono, na insuficiência cardíaca aguda, no pós operatório de cirurgia torácica e na insuficiência respiratória hipercápnica. <strong>MÉTODOS:</strong> Revisão livr

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Su, Jingdong, Hazem E. El-Osta, Reinhold Munker, Glenn M. Mills, and Srinivas S. Devarakonda. "Concomitant Acute Promyelocytic Leukemia and Chronic Lymphocytic Leukemia: Molecularly Two Distinct Diseases." Blood 126, no. 23 (2015): 4904. http://dx.doi.org/10.1182/blood.v126.23.4904.4904.

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Abstract Introduction: Acute myeloid leukemia (AML) developing in chronic lymphocytic leukemia (CLL) patients is very uncommon and is usually treatment-related. Acute promyelocytic leukemia (APL) occurring concurrently with CLL is extremely rare and there is only one published case of treatment-related APL. No case of concomitant APL and CLL in patients without history of malignancy has been found in the literature. We report such a case of coexisting CLL and APL. Case report: A 52-years-old Caucasian male with past medical history of hypertension, diabetes mellitus, and coronary artery diseas

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Nakar, Charles, Neelam Thukral, Heather L. McDaniel, Joseph M. Parker, Diane Trybul, and Amy D. Shapiro. "Acute Airway Obstruction in 4 Pediatric Patients with Congenital Plasminogen Deficiency (C-PLGD) Treated with Intravenous Plasminogen (Human) Replacement Therapy Under an Expanded Access Protocol." Blood 136, Supplement 1 (2020): 2. http://dx.doi.org/10.1182/blood-2020-137177.

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C-PLGD is a rare autosomal recessive multisystem disorder of the fibrinolytic system. Mutations in the PLG gene result in extravascular fibrinous deposits, termed ligneous for their woody appearance, that accumulate on mucous membranes such as the conjunctiva and airways, with resultant tissue injury or organ dysfunction. Ligneous conjunctivitis (LC) is the most common manifestation (&gt; 80%) of C-PLGD. Ligneous lesions affecting the respiratory system have been reported in 20% of patients in a large case series (Schuster et. al. JTH 2007). We report 3 new cases in addition to a previousl

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Nelson, Blessie Elizabeth, Adrian Gerard Murphy, and Jacquelyn W. Zimmerman. "Expecting the unexpected." Journal of Clinical Oncology 37, no. 15_suppl (2019): e14066-e14066. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14066.

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e14066 Background: Myasthenia gravis is an autoimmune neuro-muscular disorder traditionally seen in bi-modal distribution in young women or older men. Discovery of immunotherapy has brought hope in survival outcomes for patients with malignant melanoma, lung, renal and head/neck cancers but it also opens Pandora’s box of immune-related toxicities for which early recognition and appropriate clinical management are paramount. Here we describe a case of immunotherapy induced myasthenia gravis de novo. Methods: A 77-year-old man with HPV+ stage IVA squamous cell carcinoma of the tongue presented w

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Knoebl, Paul, Peter Schellongowski, Thomas Staudinger, Wolfgang R. Sperr, and Christian Scheibenpflug. "Treatment Of Infection-Associated Purpura Fulminans With Protein C Zymogen Is Associated With a High Survival Rate." Blood 122, no. 21 (2013): 3606. http://dx.doi.org/10.1182/blood.v122.21.3606.3606.

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Abstract Purpura fulminans (PF) is rapidly progressing, life-threatening disorder, characterized by skin lesions with a typical morphology, disseminated intravascular coagulopathy, multiple organ failure, septic shock, most often, but not exclusively caused by infections (meningococci, pneumococci, and others). It is associated with a breakdown of the protein C system, an important regulator of blood coagulation, leading to consumption coagulopathy, intravascular fibrin deposition, downregulated fibrinolysis, disturbance of microcirculation and finally death from multiple organ failure. Mortal

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Kavcic, Marko, Brian T. Fisher, Yimei Li, et al. "Mortality and Resource Utilization in Children with De Novo Acute Myeloid Leukemia Treated with Chemotherapy and Gemtuzumab Ozogamicin in the United States." Blood 120, no. 21 (2012): 4283. http://dx.doi.org/10.1182/blood.v120.21.4283.4283.

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Abstract Abstract 4283 Background The role of Gemtuzumab ozogamicin (GO) for acute myeloid leukemia (AML) remains controversial. GO was removed from the U.S. market in 2010 due to concerns of increased induction mortality in adults. Other studies have shown a survival benefit without increased treatment related mortality. Moreover, no data are available on the resources required to deliver GO based chemotherapy. Since pediatric data are limited, we evaluated in-hospital mortality and resource utilization in pediatric AML patients treated with GO and standard chemotherapy. Methods We used the P

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Schuettpelz, Laura, Daniel C. Link, Dong Shen, et al. "DNA Sequence of the Cancer Genome of a Patient with Therapy-Related Acute Myeloid Leukemia." Blood 116, no. 21 (2010): 580. http://dx.doi.org/10.1182/blood.v116.21.580.580.

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Abstract Abstract 580 Therapy-related acute myeloid leukemia/myelodysplasia (t-AML/t-MDS) accounts for 10–20% of all cases of AML, and its incidence is rising. Treatment options are limited and the prognosis very poor, highlighting the need for new therapies in t-AML/t-MDS. However, the genetic mutations contributing to transformation in t-AML/t-MDS are largely unknown, limiting the development of novel targeted therapeutics. Our group previously reported the sequence of the first two cancer genomes, both in patients with de novo AML (Nature 456:66, 2008; NEJM 361:1058, 2009). Herein, we repor

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Zhou, Xiaoqin, David B. Loran, Dongfang Wang, Brannon R. Hyde, Scott D. Lick, and Joseph B. Zwischenberger. "Seventy-two hour gas exchange performance and hemodynamic properties of NOVALUNG®iLA as a gas exchanger for arteriovenous carbon dioxide removal." Perfusion 20, no. 6 (2005): 303–8. http://dx.doi.org/10.1191/0267659105pf838oa.

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Objective: Acute respiratory failure is complicated by acidosis and altered end-organ perfusion. NOVA-LUNG®iLA is an interventional lung assist (ILA) device for arteriovenous carbon dioxide removal (AVCO2R). The present study was conducted to evaluate the device for short-term CO2 removal performance and hemodynamic response. Methods: Six adult sheep received cannulation of the jugular vein and carotid artery. The ILA-AVCO2R circuit was placed on the sheep for 72 hours. Hemodynamics and PaCO2 were measured; CO2 removal was calculated while varying sweep gas flow rates (Qg), device blood flow r

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Ma, Jun, Junbin Hu, Li Liu, et al. "Analysis of short-term efficacy and safety of mitoxantrone hydrochloride liposome regimen therapy in adult acute myeloid leukemia." Journal of Clinical Oncology 41, no. 16_suppl (2023): 7039. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.7039.

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7039 Background: Acute myeloid leukemia (AML) is highly heterogeneous, and more than half of patients (pts) will experience refractory or relapse, with poor prognosis. Currently, chemotherapy and hematopoietic stem cell transplantation (HSCT) are the main treatments for AML. Mitoxantrone is a synthetic anthracenedione anti-cancer drug that is effective in lymphoma, leukemia, and other solid tumors. Mitoxantrone hydrochloride liposome (PLM60) is the first approved mitoxantrone nano-drug, which has shown favorable pharmacokinetic characteristics and significantly prolong the survival time of ani

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Schellongowski, Peter, Philipp Wohlfarth, Kundi Michael, et al. "Incidence of Intensive Care Unit Admission, Outcome, and Post Intensive Care Survival in Patients with Acute Lymphocytic Leukemia or Burkitt Lymphoma." Blood 124, no. 21 (2014): 2633. http://dx.doi.org/10.1182/blood.v124.21.2633.2633.

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Abstract Acute lymphocytic leukemia (ALL) and Burkitt lymphoma (BL) are highly aggressive hematologic neoplasms. We analyzed reasons for and the incidence of admission to the intensive care unit (ICU) in de novo ALL/BL patients (pts) as well as their ICU and long-term outcome. A total of 177 consecutive pts (age 15-88 years, f/m ratio 1:1.3), including 135 with ALL (B-ALL, n=12; c-ALL, n=26; prae-B-ALL, n=33; T-ALL, n=28; bcr/abl+ ALL, n=29; T-LBL, n=3; ALL NOS, n=4) and 42 with BL were analyzed retrospectively. First-line chemotherapy (CHT) was administered between 02/1995 and 01/2013 accordi

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Ingram, Kara, Robert Wilson, Jason M. Doherty, Daniel B. Eaton, and Martin W. Schoen. "Hospitalizations in veterans treated with monotherapy vs combination therapy for metastatic hormone sensitive prostate cancer." Journal of Clinical Oncology 43, no. 5_suppl (2025): 72. https://doi.org/10.1200/jco.2025.43.5_suppl.72.

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72 Background: Current treatment of metastatic hormone sensitive prostate cancer (mHSPC) includes androgen deprivation therapy (ADT) monotherapy or combination therapy (ADT + docetaxel or an androgen receptor pathway inhibitor). However, no comparative studies have been conducted to assess the hospitalization rates and causes of admission between the two treatment groups. We assessed the hospitalization rates of the different therapies to determine adverse events and improve treatment selection in mHSPC. Methods: A nationwide retrospective study of 6,651 US Veterans with de novo mHSPC in the V

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Carregosa Ribeiro, Keyse Mirelle, Karen Monique Carregosa Ribeiro, Aloisio Santos Neto, et al. "ACOMETIMENTO E INCIDÊNCIA POR COVID-19 EM PACIENTES PEDIÁTRICOS NOS ESTADOS DE ALAGOAS E DA BAHIA." Diálogos & Ciência 1, no. 42 (2021): 113–22. http://dx.doi.org/10.7447/1678-0493.2021v1n42p113-122.

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RESUMO Introdução: O novo coronavírus, descoberto aproximadamente em 2019, recebeu o nome de SARS-CoV-2 (coronavírus 2 da síndrome respiratória aguda grave), cujo foi denominado pela Organização Mundial da Saúde (OMS) de COVID-19. Surgiu na China, disseminando por todo o mundo e rapidamente se tornou um grande desafio a ser enfrentado pela sociedade. Tal comorbidade está associada a amplo cenário de óbitos mundialmente. Entretanto, na pediatria apresentam menores taxas de incidências e complicações. Material e Métodos: Base de dados do LILACS, SCIELO e PUBMED. Os descritores utilizados:

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Sun, Jie, Zhen Wang, Yi Luo, et al. "Imatinib Combined with Chemotherapy and Allogeneic Stem Cell Transplantation Results In Long Time Survival In Patients with De Novo Ph+ AML." Blood 116, no. 21 (2010): 4368. http://dx.doi.org/10.1182/blood.v116.21.4368.4368.

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Abstract Abstract 4368 De novo Philadelphia chromosome-positive acute myeloid leukemia is a rare condition with a poor prognosis. Allogeneic stem cell transplantation (allo-SCT) is always recommended to treat this disease although its results are not always satisfactory even in young patients. Imatinib is a protein tyrosine kinase inhibitor that has now been shown to be active in Ph+ chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia, however its role in Ph+ AML has not been extensively investigated. We present two patients with de novo Ph+ AML who received Imatinib combined with ch

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Villgran, Vipin Das, Caitlan Lyons, Adeel Nasrullah, Charmaine Clarisse Abalos, Eric Bihler, and Ahmad Alhajhusain. "Acute Respiratory Failure." Critical Care Nursing Quarterly 45, no. 3 (2022): 233–47. http://dx.doi.org/10.1097/cnq.0000000000000408.

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Nishikawa, Masanori. "Acute Respiratory Failure." Nihon Naika Gakkai Zasshi 100, no. 7 (2011): 2000–2005. http://dx.doi.org/10.2169/naika.100.2000.

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Birkun, A. A., and O. O. Osunsanya. "Acute Respiratory Failure." EMERGENCY MEDICINE, no. 7.78 (December 20, 2016): 102–8. http://dx.doi.org/10.22141/2224-0586.7.78.2016.86102.

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Hankins, Gary D. V. "Acute Respiratory Failure." Clinical Obstetrics and Gynecology 33, no. 3 (1990): 493–501. http://dx.doi.org/10.1097/00003081-199009000-00015.

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Klein, E. F. "ACUTE RESPIRATORY FAILURE." Critical Care Medicine 16, no. 8 (1988): 820. http://dx.doi.org/10.1097/00003246-198808000-00027.

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Kelly, Maryann. "Acute Respiratory Failure." American Journal of Nursing 96, no. 12 (1996): 46. http://dx.doi.org/10.1097/00000446-199612000-00046.

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Frat, Jean-Pierre, Damien Marie, and Arnaud W. Thille. "Acute respiratory failure." Current Opinion in Critical Care 25, no. 6 (2019): 591–96. http://dx.doi.org/10.1097/mcc.0000000000000670.

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