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Suwake, Natsuko. "D-type cyclins and DNA damage response". Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506678.
Pełny tekst źródłaLu, Kan. "Dynamics Based Damage Detection of Plate-Type Structures". University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1133818717.
Pełny tekst źródłaSuwaki, Natsuko. "D-type cyclins and the DNA damage response". Thesis, Imperial College London, 2008. http://hdl.handle.net/10044/1/5718.
Pełny tekst źródłaBodin, Jean-Matthieu Marie Jacques Sebastien. "Buried Pipe Life Prediction in Sewage Type Environments". Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/9738.
Pełny tekst źródłaMaster of Science
Moy, Inge. "Parameter Sensitivity of Short-term Fatigue Damage of Spar-type Wind Turbine Tower". Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for marin teknikk, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-18511.
Pełny tekst źródłaRosales, HernaÌndez Alma L. "Mechanisms of β cell DNA damage and repair in type 1 diabetes mellitus". Thesis, University of Brighton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247817.
Pełny tekst źródłaConnaughton, M. D. "A study of cumulative fatigue and creep-fatigue damage in Type 316 steel". Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234153.
Pełny tekst źródłaPeat, D. S. "The effect of herpes simplex virus type 1 on chromosomes of human cells". Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383841.
Pełny tekst źródłaReiner, Joachim Christian. "Latent gate oxide damage induced by ultra-fast electrostatic discharge /". [S.l.] : [s.n.], 1995. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=11212.
Pełny tekst źródłaLyraki, Rodanthi. "Molecular mechanisms underlying Retinitis pigmentosa type 2". Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31254.
Pełny tekst źródłaEmam, Aly A. "Frequency response of laminated composite plates and shells with matrix cracks type of damage mode /". The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu148794915006947.
Pełny tekst źródłaLee, Matthew L., i Jonathan M. Peterson. "CTRP3 Protects Liver Cells From Alcohol-Induced Damage, But Not Through Enhanced Akt Signaling Type". Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/70.
Pełny tekst źródłaJones, Danielle Alice. "Adipose tissue as a mediator of inflammation and oxidative cellular damage in obesity and type 2 diabetes". Thesis, Swansea University, 2013. https://cronfa.swan.ac.uk/Record/cronfa42244.
Pełny tekst źródłaVeinhard, Matthieu. "Endommagement surfacique de la silice avec des faisceaux laser de type LMJ". Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0029.
Pełny tekst źródłaEach of the 176 beams of the Laser MégaJoule (LMJ) facility will deliver an energy of 8 kJ at 351 nm, in the nanosecond regime, on a millimeter scale target. This energy density is likely to be absorbed by sub-surface defects induced by the polishing processes. This absorption eventually leads to laser-induced damage sites. These initiated damage sites absorb the laser energy during the subsequent shots and are likely to grow in size. The thick (34mm) optical windows situated after the frequency conversion module are exposed to the highest laser energies at 351nm and are the most sensitive to these phenomena. The goal of this thesis is to study the initiation and growth of damage sites on thick optical components with a laser beam that have similar properties to those of a LMJ beam. Such a beam can be delivered by the MELBA facility which can reach similar energy densities to those that can be found on the LMJ. The beam energy is evenly distributed on a centimeter scale circular aperture and the pulse shape and duration can be defined by the user. Three main axes have been explored in this work. The measurement of damage initiation on thick fused silica optical components have firstly been studied with an accurate metrology of the energy density after the propagation through the optical component, thus taking Kerr small scale self focusing into account. The growth of a population of damage sites have secondly been studied as a function of the laser fluence and pulse duration. Finally, the growth of damage sites up to millimeter scales have been studied
Fritsche, Stefan. "Large historical earthquakes in Switzerland : multidisciplinary studies on damage fields and site-effects /". Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17710.
Pełny tekst źródłaPenchikala, Madhuri. "ANGIOTENSIN AT1 RECEPTOR BLOCKADE PROTECTS THE BRAIN FROM ISCHEMIC DAMAGE". Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1187382272.
Pełny tekst źródłaMorency, Eric. "The protein of herpes simplex virus Type 1 : from centromeres to the interphase centromere damage response". Lyon 1, 2007. http://www.theses.fr/2007LYO10317.
Pełny tekst źródłaSoares, Bruno Marques. "Hellebrigenina, um BufodienolÃdeo com Potencial AÃÃo CompatÃvel de Inibidor CatalÃtico da Topoisomerase II". Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10367.
Pełny tekst źródłaOs bufodienolÃdeos sÃo esterÃides cardioativos de 24 carbonos, isolados originalmente de um extrato de pele de sapos da famÃlia Bufonidae utilizado na medicina chinesa. Os bufodienolÃdeos possuem grande variedade de atividades biolÃgicas, incluindo atividades antineoplÃsicas. Em relaÃÃo à atividade antitumoral, os bufodienolÃdeos tem demonstrado inibir o crescimento de vÃrias linhagens de cÃlulas cancerÃgenas humanas por induzir apoptose e parada do ciclo celular. O presente estudo avaliou o potencial citotÃxico e genetÃxico de seis bufodienolÃdeos em seis linhagens tumorais humanos, trÃs linhagens murinas normais e cÃlulas mononucleadas do sangue perifÃrico (CMSP) humano. Todos os seis bufodienolÃdeos foram citotÃxicos para todas as linhagens tumorais e CMSP com valores de IC50 variando entre 0,002 e 3,17 ÂM. Os bufodienolÃdeos testados nÃo apresentaram citotoxicidade para linhagens murinas normais. Desta forma, o composto hellebrigenina foi escolhido para se determinar o mecanismo de aÃÃo envolvido. Uma sequÃncia de experimentos in vitro foram realizados utilizando-se a linhagem leucÃmica HL-60. As cÃlulas foram tratadas em diferentes concentraÃÃes da amostra hellebrigenina (0,03, 0,06 e 0,12 ÂM) por 24 horas. A viabilidade das cÃlulas (nÃmero de cÃlulas viÃveis e integridade de membrana) HL-60 avaliada por citometria de fluxo, mostrou que o nÃmero de cÃlulas reduziu a partir da menor concentraÃÃo (0,03 ÂM) testada e a porcentagem de cÃlulas com membrana integra reduziu a partir da concentraÃÃo 0,06 ÂM. A anÃlise morfolÃgica por citometria de fluxo revelou aumento de cÃlulas com padrÃo apoptÃtico a partir da concentraÃÃo de 0,06 ÂM. Jà a anÃlise do conteÃdo nuclear, nos mostrou aumento de fragmentaÃÃo de DNA sub-G1 indicativo de apoptose e acÃmulo de cÃlulas na fase G2/M a partir das concentraÃÃes de 0,03 e 0,06 ÂM, respectivamente. Outros testes por citometria de fluxo revelaram que houve externalizaÃÃo da fosfatidilserina, despolarizaÃÃo mitocondrial, ativaÃÃo da caspase iniciadora 8 e consequente ativaÃÃo das caspases efetoras 3 e 7. Estes dados indicam um mecanismo citotÃxico por induÃÃo de mais de uma via apoptÃtica. Hellebrigenina nÃo foi capaz de causar danos ao DNA de HL-60 e de CMSP e nem o surgimento de aberraÃÃes cromossÃmicas em CMSP. Por meio dos estudos de docking molecular foi possÃvel predizer a ligaÃÃo entre hellebrigenina e topoisomeraseIIα humana, resultado compatÃvel com a possÃvel inibiÃÃo dessa enzima. De forma geral, os resultados apontam o potencial citotÃxico do bufodienolÃdeo hellebrigenina
Bufodienolides are cardioactive steroids of 24 carbons, originally isolated from a frogâs skin extract of the family Bufonidae used in Chinese medicine. Bufodienolides shows many biological activities, including anticancer activities. Related to antitumor activity, the bufodienolÃdeos has been shown to inhibit the growth of several human cancer cell lines by inducing apoptosis and cell cycle arrest. This study evaluated the potential cytotoxicity and genotoxicity of six bufodienolides, in six human tumor cell lines, three normal murine lineages and PBMC (peripheral blood mononuclear cells). All six bufodienolides were cytotoxic to all cell lines and tumor PBMC with IC50 values ranging from 0.002 to 3.17 ÂM. Bufodienolides showed no cytotoxicity for normal murine strains. Thus, the compound hellebrigenin was chosen to determine the action mechanism involved, a sequence of in vitro experiments were performed using HL-60 leukemia cell line. Cells were treated at different concentrations of hellebrigenin (0.03, 0.06 and 0.12 ÂM) for 24 hours. Cell viability (viable cell number and membrane integrity) HL-60 assessed by flow cytometry showed that the number of cells decreased from the lower concentration (0.03 ÂM) tested and the percentage of cells with reduced membrane integrity from 0.06 ÂM concentration. Morphological analysis by flow cytometry revealed increased apoptotic cells starting at concentrations of 0.06 ÂM. The analysis of nuclear content, showed an increase in DNA fragmentation indicative of sub-G1 apoptosis and accumulation of cells in G2 / M phase from the concentrations of 0.03 and 0.06 ÂM, respectively. Other tests by flow cytometry revealed that there was an externalization of phosphatidylserine, mitochondrial depolarization, activation of caspase 8 and initiating subsequent activation of effector caspases 3 and 7. These data indicate a cytotoxic mechanism induced by over an apoptotic pathway. Hellebrigenin was not able to cause DNA damage in HL-60 and PBMC nor the emergence of chromosomal aberrations in PBMC. Through the studies of molecular docking was possible to predict the connection between hellebrigenina and human topoisomeraseIIα, showing a result that is compatible with a possible inhibition of this enzyme. Overall, the results indicate the potential cytotoxicity of hellebrigenin
Windt, Leon Johannes de. "Ischemia and reperfusion-induced damage of the isolated mouse heart involvement of type IIA secretory phospholipase A2 /". [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1999. http://arno.unimaas.nl/show.cgi?fid=6892.
Pełny tekst źródłaHu, Shuting, i 胡舒婷. "Resorcinol-type phenolic compounds from natural sources inhibut α-MSH induced melanogenesis and UVA-induced DNA damage". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207207.
Pełny tekst źródłapublished_or_final_version
Biological Sciences
Doctoral
Doctor of Philosophy
Holtzapple, Emilee R. "RelA as a Potential Regulator of Inflammation and Tissue Damage in Streptozotocin-Induced Diabetic STAT5 Knockout Mice". Ohio University Honors Tutorial College / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1461342848.
Pełny tekst źródłaMartinez-Flores, Rene. "DAMAGE ASSESSMENT POTENTIAL OF A NOVEL SYSTEM IDENTIFICATION TECHNIQUE - EXPERIMENTAL VERIFICATION". Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1028%5F1%5Fm.pdf&type=application/pdf.
Pełny tekst źródłaBOTTRELL, John Robert, i John Bottrell@dsl-riotinto com au. "ACCIDENT DENOMINATORS RELATIVE TO AGE GROUPS IN HEAVY INDUSTRIES OF THE PORT HEDLAND REGION OF WESTERN AUSTRALIA". Edith Cowan University. Computing, Health And Science: School Of Exercise, Biomedical & Health Science, 2007. http://adt.ecu.edu.au/adt-public/adt-ECU2007.0045.html.
Pełny tekst źródłaGibbs-Seymour, Ian David. "The multiple roles of A-type lamins in cellular aging, cell cycle progression and the DNA damage response". Thesis, Durham University, 2011. http://etheses.dur.ac.uk/3491/.
Pełny tekst źródłaВіхрова, Ірина Олександрівна, Ирина Александровна Вихрова, Iryna Oleksandrivna Vikhrova, Андрій Миколайович Лобода, Андрей Николаевич Лобода i Andrii Mykolaiovych Loboda. "Significance of urinary Aminopeptidase N in early diagnosis of kidney damage in children with type 1 diabetes mellitus". Thesis, Lithuanian University of Health Sciences, 2021. https://essuir.sumdu.edu.ua/handle/123456789/83663.
Pełny tekst źródłaЦель. Целью настоящего исследования было изучить особенности уровней Аминопептидазы N (ANPEP) в моче у детей в зависимости от продолжительности диабета. Методы. Мы проанализировали 3 группы детей с сахарным диабетом 1 типа и группу сравнения детей без диабета из Областной детской клинической больницы г. Сумы. ANPEP измеряли с помощью иммуноферментного анализа с использованием набора антител к биомаркерам почек человека (R&D Systems, Миннеаполис, Миннесота, США). Результаты были получены с помощью BioRad ChemiDoc Touch. Массивы анализировали полуколичественно с использованием программного обеспечения BioRad Image Lab. Результаты. В исследование были включены 47 детей с диабетом и 8 детей без диабета. Уровень ANPEP в моче увеличился в 2,6 раза у детей с длительностью диабета менее одного года по сравнению с контрольной группой. Уровни ANPEP были повышены в 3,2 раза у детей с длительностью диабета от одного до пяти лет. У детей с длительностью диабета более 5 лет маркер увеличился в 2,7 раза. Заключение. Повышение уровня ANPEP в моче наблюдалось в первый год диабета у детей. Измерение уровня ANPEP в моче может быть полезно для диагностики диабетической нефропатии.
Aim. The aim of the current study was to investigate the features ANPEP levels in urine of children depending on the duration of diabetes. Methods. We analysed 3 groups of children with type 1 diabetes mellitus and comparison group of children without diabetes from Regional Children’s Clinical Hospital in Sumy. ANPEP was measured by ELISA using a Proteome Profiler Human Kidney Biomarker Antibody Array (R&D Systems, Minneapolis, MN, USA). Results were detected with BioRad ChemiDoc Touch. The arrays were analysed semiquantitatively, using BioRad Image Lab Software. Results. The study included 47 children with diabetes and 8 children without diabetes. The level of ANPEP in urine increased 2.6-fold in children with the duration of diabetes below one year compared to the control group. ANPEP levels were elevated 3.2-fold in children with duration of diabetes from one to five years. In children with duration of diabetes duration, the marker increased 2.7 times. Conclusion. Increase urinary ANPEP was observed in the first year of diabetes in children. Measuring the level of ANPEP in urine may be useful for the diagnosis of diabetic nephropathy.
Datta, Antara. "Human T Lymphotropic Virus Type 1 (HTLV-1) Accessory Protein p30 Modulates Cell Cycle and DNA Damage Signaling". The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1184007936.
Pełny tekst źródłaChitnis, Meenali M. "Type 1 insulin-like growth factor receptor inhibition as treatment for urological cancer". Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:21282ce9-ce6b-4d26-b262-a3fca6d9c9fc.
Pełny tekst źródłaDumas, Karine. "Implication de la protéine REDD1 dans les maladies métaboliques associées à l’obésité : REDD1 = Regulated in Development and DNA damage responses 1". Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://www.theses.fr/2019AZUR4045.
Pełny tekst źródłaObesity is defined as an abnormal fat accumulation which could lead to health disorders and its prevalence is in constant increase worldwide. Obesity is associated with insulin resistance, hepatic steatosis and type 2 diabetes. REDD1 (Regulated in Development DNA damages responses 1) regulates most of signaling pathways implicated in cell energetic balance. In my host lab, we have demonstrated that REDD1 is implicated in insulin signaling pathway. The goal of my thesis was to study the REDD1 implication in obesity associated metabolic diseases. We observed that REDD1 expression was increased in epidydimal adipose tissue and in liver of control high fat diet (HFD) fed-mice (WT). Furthermore, REDD1 expression was increased in liver biopsies from obese patients with hepatic steatosis and its expression was correlated with the severity of the pathology and insulin resistance. To identify the role of REDD1 in the development of obesity-induced diseases, we have characterized the phenotype of REDD1 knockout mice (REDD1-KO) fed with HFD. Under HFD, the REDD1-KO mice showed a similar weight gain and insulin resistance compared to WT mice. Interestingly, REDD1-KO mice were protected from hepatic steatosis under HFD. In liver of REDD1-KO mice, no modification of protein expression implicated in hepatic lipid flux was observed. In REDD1-KO mice liver, we observed a decrease of protein expression implicated in lipogenesis pathways associated to an increase of the expression of proteins involved in β-oxydation. In WT mice, hepatic steatosis is correlated with an increase of mitochondrial size. In REDD1-KO mice, HFD did not induce an enlargement of mitochondria. Moreover, the expression pattern of proteins involved in autophagy and mitophagy is increased in HFD REDD1-KO livers. Our results suggest that in HFD conditions, liver of REDD1- KO mice could be protected from mitochondrial dysfunction because of an increase of mitophagy. In a second part of my thesis, we have studied the effect of partial decrease of REDD1 expression on obesity-induced complications using REDD1 heterozygous mice (REDD1-He). Partial decrease of REDD1 did not influence weight gain and hepatic steatosis development under HFD compared to WT mice. However, REDD1-He mice have developed an important glucose and insulin resistance under HFD compared to WT mice. This is associated with an impairment of the use of lipid as substrate during fasting. To conclude, my thesis research project allows us to show for the first time that REDD1 is implicated in hepatic steatosis under obesity
Yu, Yanan. "NF1 Patient Missense Variants Predict a Role for ATM in Modifying Neurofibroma Initiation". University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1592395217393569.
Pełny tekst źródłaHemmings, K. E., Kirsten Riches-Suman, M. A. Bailey, D. J. O'Regan, N. A. Turner i K. E. Porter. "Role of microRNA-145 in DNA damage signalling and senescence in vascular smooth muscle cells of Type 2 diabetic patients". MDPI, 2021. http://hdl.handle.net/10454/18477.
Pełny tekst źródłaIncreased cardiovascular morbidity and mortality in individuals with type 2 diabetes (T2DM) is a significant clinical problem. Despite advancements in achieving good glycaemic control, this patient population remains susceptible to macrovascular complications. We previously discovered that vascular smooth muscle cells (SMC) cultured from T2DM patients exhibit persistent phenotypic aberrancies distinct from those of individuals without a diagnosis of T2DM. Notably, persistently elevated expression levels of microRNA-145 co-exist with characteristics consistent with aging, DNA damage and senescence. We hypothesised that increased expression of microRNA-145 plays a functional role in DNA damage signalling and subsequent cellular senescence specifically in SMC cultured from the vasculature of T2DM patients. In this study, markers of DNA damage and senescence were unambiguously and permanently elevated in native T2DM versus non-diabetic (ND)-SMC. Exposure of ND cells to the DNA-damaging agent etoposide inflicted a senescent phenotype, increased expression of apical kinases of the DNA damage pathway and elevated expression levels of microRNA-145. Overexpression of microRNA-145 in ND-SMC revealed evidence of functional links between them; notably increased secretion of senescence-associated cytokines and chronic activation of stress-activated intracellular signalling pathways, particularly the mitogen-activated protein kinase, p38a. Exposure to conditioned media from microRNA-145 overexpressing cells resulted in chronic p38a signalling in naïve cells, evidencing a paracrine induction and reinforcement of cell senescence. We conclude that targeting of microRNA-145 may provide a route to novel interventions to eliminate DNA-damaged and senescent cells in the vasculature and to this end further detailed studies are warranted.
Danga, Helga Tariro. "Investigation of electron-beam deposition and related damage in p-Si by means of Laplace and conventional deep-level transient spectroscopy". Thesis, University of Pretoria, 2019. http://hdl.handle.net/2263/77896.
Pełny tekst źródłaThesis (PhD)--University of Pretoria, 2019.
Physics
PhD
Unrestricted
Afsar, Nilufer. "Effect Of Cold Stress On Antioxidant Mechanism Of Winter And Spring Type Barley ( Hordeum Vulgare L.) Cultivars". Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12608514/index.pdf.
Pełny tekst źródłaC for 1, 3 and 7 days, and for freezing stress application acclimated cultivars (+4 º
C for 3 days) were treated with -3 º
C and -7 º
C. After freezing stress treatment, a recovery period was applied for 4 days at 4 º
C. Following analyses were performed on leaf and root tissues: growth parameters (length, wet-dry weights), malondialdehyde (MDA) content, proline content, hydrogen peroxide content (H2O2) electrolyte leakage, PS II fluorescence (Fv/Fm), antioxidant enzyme activities such as catalase (CAT: EC 1.11.1.6), ascorbate peroxidase (APX: EC 1.11.1.11) and glutathione reductase (GR: EC 1.6.4.2). It was observed that effect of cold was more at freezing temperatures than chilling temperature. Cold dependent damage was more obvious as the duration of chilling temperature increased. Growth retardation, membrane damage, leaf catalase deactivation were more apparent and leaf glutathione reductase activity increase was less in spring type cultivar Zafer than in winter type Tarm. These results indicated that winter type barley cultivar is more cold tolerant than spring type barley.
Fiskin, Gokce. "A Case Study On The Stability Of Berm Type Coastal Defense Structures". Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605604/index.pdf.
Pełny tekst źródłas approach and berm design guidelines, with a scale of 1/31.08 and they were tested both for breaking and non-breaking waves. The experiments took place in the Coastal and Harbor Engineering Laboratory of the Middle East Technical University, Civil Engineering Department. The models were constructed and tested with different berm widths and armor stone sizes forming the back armor layer in order to examine the effect of these design parameters on the stability and serviceability of the coastal defense structure to obtain the optimum alternative cross-section. Cumulative damage was minimum for the cross-section constructed with berm width 15 m assigning the width of the prototype. Water spray and run-up values were also not significant. The test results were confirming with Van Der Meer design approach.
Gaborit, Pierre. "Unification des modèles d’endommagement de type Lemaitre, pour la fatigue LCF/HCF, multiaxiale et aléatoire". Thesis, Cachan, Ecole normale supérieure, 2015. http://www.theses.fr/2015DENS0041.
Pełny tekst źródłaThis work presents the proposal of a unifying predictive model to deal with LCF and HCF problems. It is based on a two-scale approach initially developed by Lemaitre. As the damage evolution law is rate written, complexity due to non proportional and random loadings may also be treated. An experimental fatigue campaign of 12 cross shaped samples made of TA6V alloy for aerospace applications is presented. It includes not only proportional and non proportional biaxial tests but also pseudo random loadings. Digital Image Correlation is used to evaluate the local strains from pictures taken in the zone of interest. Loadings are the simulated and both strains and lifetimes are compared to experimental observations. Among the theoretical contributions presented in this work, the main are: - A new kinematic hardening evolution law for the modeling of elasto-plasticity of TA6V alloy under cyclic loadings; - Use of local elastoplastic correction from linear Finite Element Calculation to estimate plastic strains in the structure zone of interests; - Improvements of the micro-plastic yield function to take into account mean stress effect and triaxiality effects in the lifetime prediction in HCF domain; - A unifying method of two damage variables in order to extend the validity domain of the initial model to shorter lifetimes (LCF). As the model is based on a thermodunamical framework for continuum mechanics, several extension are mentioned as future propects
Sweetman, Sandra Frances. "An investigation of bleomycin induced DNA damage and repair in wild-type and thymidine kinase deficient human and murine cell lines". Thesis, University of Ulster, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242069.
Pełny tekst źródłaSánchez, Peña Enric. "Estudi DMAGE: Diabetes Mellitus and damage caused by Advanced Glycation End-products". Doctoral thesis, Universitat de Lleida, 2018. http://hdl.handle.net/10803/663150.
Pełny tekst źródłaLos productos finales de glicación avanzada (AGEs) constituyen un grupo complejo de compuestos formados por la lenta glicación no enzimática de proteínas, lípidos y ácidos nucleicos, de los que se han dilucidado aproximadamente 20 hasta el presente. No existe evidencia de si la magnitud de la deposición de AGEs en el tejido subcutáneo está relacionada con la enfermedad ateromatosa, las primeras etapas de la enfermedad renal crónica, la función pulmonar y la obesidad. Estos son los primeros estudios en que la autofluorescencia cutánea (SAF) se ha evaluado en una cohorte asintomática de mediana edad sin eventos cardiovasculares conocidos que muestran una estrecha relación entre la SAF y la carga de placas ateromatosas así como con la disfunción renal y pulmonar. También hay una SAF aumentada en pacientes con obesidad mórbida y síndrome metabólico principalmente a expensas de la presencia de diabetes mellitus tipo 2. Durante los primeros 5 años después de la cirugía bariátrica, no se observó una disminución de la SAF.
The advanced glycation end-productsAGEs constitute a complex group of compounds formed by the slow non-enzymatic glycation of proteins, lipids, and nucleic acids, of which about 20 have been elucidated to date. No evidence exists whether the magnitude of the AGEs deposition in subcutaneous tissue are related with the atheromatous disease, the first stages of chronic kidney disease, the pulmonary function as well as obesity. These are the first studies in which skin autofluorescence (SAF) has been evaluated in a middle-aged asymptomatic cohort without known cardiovascular events displaying a close relationship between SAF and atheromatous plaque burden as well as kidney and pulmonary dysfuncion. There is also an increased SAF in patients with morbid obesity and metabolic syndrome mainly at the expense with the presence of type 2 diabetes. During the first 5 years after bariatric surgery, are not associated with a decrease in SAF.
Ozler, Basar. "A Case Study On The Submerged Berm Type Coastal Defense Structures". Master's thesis, METU, 2004. http://etd.lib.metu.edu.tr/upload/12605605/index.pdf.
Pełny tekst źródłas approach and berm design guidelines. Models were constructed with a model scale of 1:31.08 in the wave flume in the Coastal and Harbor Engineering Laboratory, Civil Engineering Department, METU. The newly designed and optimized berm type structure was proved to be successful and economical.
Bottrell, John R. "Accident denominators relative to age groups in heavy industries of the Port Hedland region of Western Australia". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2007. https://ro.ecu.edu.au/theses/8.
Pełny tekst źródłaGuillaud, Nicolas. "Tolérance aux dommages générés par impact de structures composites épaisses. Application aux réservoirs composites hyperbares". Thesis, Paris, ENSAM, 2015. http://www.theses.fr/2015ENAM0040/document.
Pełny tekst źródłaThis thesis took place within the framework of the project TOLEDO (Tolerance in the damage by impact of the hyperbaric reservoirs) managed by Air Liquide in partnership with the CEA Le Ripault and PPRIME institute.The hydrogen is stored within the type IV vessel at a servive pressure of 700 bar.These composite structures present as peculiarities to be thick (> 30 mm), to have a strong curvature and to be precharged in pressure during a possible impact.Our work showed that these peculiarities modify the type, the quantity and the localization of the various usually observed damages (fiber breakage, délamination and matrix cracking).The damages were able to be quantified by means of simple and original methods.The influence of the peculiarities on the behavior in the impact was able to be determined by the use of two experimental devices designed and realized during this thesis.The first one allows to preload a thick composite plates in uniaxial tension thick composite plates.The second allows to preload in state of membrane a composite pipe and allowed to show that the most critical impact towards reservoirs is when they are empty.This study allowed to highlight the criticality of the fiber breakage on the loss of performance within the hyperbaric reservoirs.A digital model taking into account the dispersal of the failure stress and various types of damages was developed.It also allows to introduce an initial damage and confirm some experimental results
Keller, Seitz Monika U. "The role of recombination in aflatoxin B₁-induced DNA damage in Saccharomyces cerevisiae and the Seg1 protein of Saccharomyces cerevisiae is a membrane-associated multidrugtransporter /". Zürich, 2001. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=14321.
Pełny tekst źródłaArmentrout, Erin I. "Sensing of Host Cell Contact by the Pseudomonas aeruginosa Type III Secretion System". Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1499965816504161.
Pełny tekst źródłaLaribi, Mohamed Amine. "Caractérisation et Modélisation du comportement micromécanique des matériaux composites SMC sous chargement thermomécanique de type quasi-statique et fatigue". Thesis, Paris, ENSAM, 2018. http://www.theses.fr/2018ENAM0062/document.
Pełny tekst źródłaThe composite materials are strongly conditioned by the ability of the company to design the automotive structures under various complexes loadings such as fatigue. The aim of this thesis is to develop a multi-scale modeling coupled to a phenomenological approach in order to provide a response to the dimensioning need of structural parts subjected to cyclic loading at different temperatures of 23°C, 80°C and -30°C. By this way, the work was conducted along two main lines; firstly, an experimental investigation under monotonic and fatigue loadings. The results of this experimental study provide the necessary data for the construction of a micromechanical model which constitute the basis of the second part of this work; the predictive approaches of the fatigue lifetime for SMC composite. Thus, two hybrid, phenomenological/micromechanical, modeling approaches have been proposed. Both are based on a micromechanical modeling that allows describing the mechanical behavior of our material under monotonic loading, taking into account the microstructure and the damage phenomenon. These two predictive models require only a limited number of experimental tests and investigations but remain very reliable in their capacity to predict the lifetime of an SMC composite material under fatigue loading. The approach is validated in the case of thermomechanical sequential loadings at variable temperatures or amplitudes
Doolittle, Lauren May. "The Impact of Alveolar Type II Cell Mitochondrial Damage and Altered Energy Production on Acute Respiratory Distress Syndrome Development During Influenza A Virus Infection". The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu159224389333959.
Pełny tekst źródłaShirinbayan, Mohammadali. "Étude du comportement mécanique et de l’endommagement de divers matériaux composites smc soumis à des chargements de type dynamique, fatigue et dynamique post-fatigue". Thesis, Paris, ENSAM, 2017. http://www.theses.fr/2017ENAM0013/document.
Pełny tekst źródłaClassically, crash design of automotive composite structures made of discontinuous reinforcements such as SMC is usually based on experimental data obtained from virgin materials without any history of loading. However, crash events always occur after a few years of use during which composite structure is generally subjected to more or less important fatigue loading. Taking into account of a potential pre-damage in fatigue becomes essential if we want to stay realistic. Moreover, new formulations of SMC composites have been developed recently. Up to now, their fatigue and dynamic behavior were never being explored. This study, of a mostly experimental nature, aims to provide the knowledge necessary for design of structures made of various SMC formulations including A-SMC and LD-SMC. The first one is a vinylester matrix reinforced with a high content of glass fibers (50%). The second corresponds to a standard SMC formulation in which we added a high content of hollow glass micro-sphere in order to reduce density. A systematic multi-scale analysis allows to highlight the influence of the microstructure on damage phenomena under quasi-static, dynamic and fatigue loading. Original experimental methods are developed to correlate these mechanisms to the observed macroscopic behavior. Optimized dynamic tests are performed at strain rate up to 80 s-1 and highlight a visco-damageable behavior for the two SMC materials in study. Damage threshold delay and reduction of damage kinetics observed at the macroscopic scale are directly correlated to the threshold and kinetic of damage development observed at the local scale such as fiber-matrix or matrix-microsphere interfaces, matrix micro-cracking and pseudo-delamination between the bundles of glass fiber. Moreover, a similar multi-scale analysis is also performed under fatigue loading in which the frequency ranges from 10 to 100 Hz. A study of the influence of the self-heating phenomenon on the fatigue damage behavior of A-SMC is proposed. Finally, an original analysis of the remaining dynamic properties of samples which were previously submitted to fatigue loading until different levels of lifetime highlights a strong influence of the history of the loading on the strain rate sensitivity of the A-SMC. Considering the high contribution of this study in term of comprehension of the phenomena involved in the mechanical response of SMC materials, all of the experimental findings of this study provide the physical background crucial to build structural design tools for SMC subjected to cyclic and dynamic loading
Dompierre, Benoît. "Fiabilité mécanique des assemblages électroniques utilisant des alliages du type SnAgCu". Phd thesis, Ecole Centrale de Lille, 2011. http://tel.archives-ouvertes.fr/tel-00604954.
Pełny tekst źródłaRytter, Elisabet. "Effect of Dietary Antioxidants on Oxidative Stress, Inflammation and Metabolic Factors : Studies in Subjects with Overweight and with Type 2 Diabetes". Doctoral thesis, Uppsala universitet, Oxidativ stress och inflammation, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-134938.
Pełny tekst źródłaÅsgård, Rikard. "Effects of Antioxidants and Pro-oxidants on Oxidative Stress and DNA Damage using the Comet Assay : Studies on Blood Cells from Type 2 Diabetes Subjects and Mouse Lymphoma Cells". Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-217886.
Pełny tekst źródłaLautrou, Nicolas. "Amorçage de fissure de fatigue dans un joint soudé de type naval : étude expérimentale et numérique". Université de Bretagne occidentale, 2007. http://www.theses.fr/2007BRES2051.
Pełny tekst źródłaMay, Abdelghani. "Etude du comportement cyclique et de l'endommagement par fatigue d'un alliage d'aluminium anisotrope du type 2017A". Phd thesis, INSA de Rouen, 2013. http://tel.archives-ouvertes.fr/tel-00925413.
Pełny tekst źródłaNakov, Philipp [Verfasser], i Felix [Akademischer Betreuer] Bischof. "The role of C-C motif chemokine ligand 7, C-C motif chemokine ligand 11 and interleukin-9 in T helper type 9 cell mediated neuronal damage / Philipp Nakov ; Betreuer: Felix Bischof". Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1204879877/34.
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