Artykuły w czasopismach na temat „D-341”
Kliknij ten link, aby zobaczyć inne rodzaje publikacji na ten temat: D-341.
Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych
Sprawdź 50 najlepszych artykułów w czasopismach naukowych na temat „D-341”.
Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.
Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.
Przeglądaj artykuły w czasopismach z różnych dziedzin i twórz odpowiednie bibliografie.
1
K�ckerling, F., M. Bartsch, J. Scheele i P. Hermanek. "341. D�nndarmtumoren". Langenbecks Archiv f�r Chirurgie 369, nr 1 (grudzień 1986): 854–55. http://dx.doi.org/10.1007/bf01274661.
Pełny tekst źródła
2
Zhou, Guangbiao, Zheng Hu, Dapeng Liu, Fuqun Wu, Jiang Zhu, Saijuan Chen, Xiaoli Liu, Juan Li, Xiaofeng Li i Fengxiang Zhang. "Synergic Effects of Proteasome Inhibitor PS-341 and Tyrosine Kinase Inhibitor STI571 on Chronic Myeloid Leukemia Cells and BCR-ABL Oncoprotein In Vitro and In Vivo." Blood 108, nr 11 (16.11.2006): 4771. http://dx.doi.org/10.1182/blood.v108.11.4771.4771.
Pełny tekst źródłaStreszczenie:
Abstract STI571/Gleevec/imatinib, a rationally-designed agent that occupies the ATP-binding site of BCR-ABL and stabilizes the protein in its closed, inactive conformation, has been a remarkable success for the treatment of chronic myeloid leukemia (CML). However, a significant proportion of patients chronically treated with STI571 develop resistance because of the acquisition of mutations in the kinase domain of BCR-ABL. Furthermore, the effects of STI571 on CML patients in accelerated phase or blastic crisis are unsatisfactory since many patients relapse after transient remission. Hence, additional drugs or STI571-based combination regimens are desired to circumvent resistance and to improve response rates. Here we reported that PS-341, a proteasome inhibitor which offers great promise to patients with multiple myeloma (MM), significantly enhanced the antileukemia activity of STI571 in vitro and in vivo. We found a synergy exists between low concentrations of PS-341 (5–10 nM) and STI571 (0.1–0.2 μM) in inhibition of cell growth and induction of apoptosis in K562 cell line and CD34+ leukemic cells isolated from CML patients. In K562 cells, combined use of PS-341 and STI571 accelerated activation of caspase-3, 9, and facilitated cleavage of poly-(ADP-ribose) polymerase (PARP) as compared to those in cells treated with PS-341 or STI571 alone. Moreover, PS-341/STI571 combination resulted in potentiated degradation of BCR-ABL and downregulation of phosphorylated BCR-ABL as compared to those in mono treatment. In nude mice inoculated subcutaneously with K562 cells, treatment with PS-341 (injected intraperitoneally, ip) alone (at doses of 0.05, 0.5, 1 mg/kg/d, twice a week for 4 weeks, respectively) decreased tumor growth in a dose-dependent manner. STI571 (ip) at 10 mg/kg/d also inhibited tumor growth. Intriguingly, combinatory administration of low dose PS-341 (0.05 mg/kg/d, twice a week for 4 weeks) and STI571 (10 mg/kg/d) yielded a much more profound inhibition of tumor growth and even clearance of leukemic cells in mice compared to either monotherapy. Taken together, these results demonstrate synergic effects of PS-341 and STI571, and provide the rationale to evaluate PS-341/STI571 combination in treating CML aiming to further improve clinical outcome of patients.
3
Dinisi, Patrice, Patrick Ohlmann, Olivier Morel, Bogdan Radulescu, Hélène Petit, Philppe Billaud, Michel Kindo i in. "341 Kinetics and prognostic value of D-Dimer in acute aortic dissection". Archives of Cardiovascular Diseases Supplements 2, nr 1 (styczeń 2010): 112–13. http://dx.doi.org/10.1016/s1878-6480(10)70343-8.
Pełny tekst źródła
4
WANG, Kun-Ching. "An Adaptive Wavelet-Based Denoising Algorithm for Enhancing Speech in Non-stationary Noise Environment". IEICE Transactions on Information and Systems E93-D, nr 2 (2010): 341–49. http://dx.doi.org/10.1587/transinf.e93.d.341.
Pełny tekst źródła
5
Tuppad, Pramod, Awadhesh Kishore, Srivatsa S. Kharad i Jai Dev Sharma. "Effect of Nitrogen Levels on the Growth and Yield of Barley (Hordeum vulgare L.) Varieties". Ecology, Environment and Conservation 29, nr 01 (2023): 156–60. http://dx.doi.org/10.53550/eec.2023.v29i01.025.
Pełny tekst źródłaStreszczenie:
A field experiment entitled “Effect of nitrogen levels on the growth and yield of barley (Hordeum vulgare L.) Varieties” was carried out during the Rabi season of 2021-22 near the polyhouse research farm of wheat, barley, and mustard section, ITM University, Gwalior. The experiment was carried out in a randomized block design with three replications. Twelve treatments consist of four levels of nitrogen (0, 40, 80, and 120 kg N ha-1) and three barley varieties (RD-2035, KBS-D-341, and BH-393). Results indicated that the application of different nitrogen levels and varieties had significant effects on plant growth parameters such as plant height, number of tillers, leaf area, and dry matter accumulation. Increased levels of nitrogen considerably influenced the yield characters and were maximum when 120 kg N ha-1 was applied; however, it was at par with 80 kg N ha-1. The highest grain yield (4312.23 kg ha-1) was recorded with the application of 120 kg N ha-1 which was significantly higher as compared to lower levels (0 and 40 kg N ha-1) of nitrogen except for 80 kg N ha-1.The application of 40, 80, and 120 kg N ha-1 increased the grain yield by 57.13, 73.48, and 74.29 per cent, respectively over 0 kg N ha-1. Among varieties, KBS-D-341 produced maximum plant height, number of tillers, leaf area, and dry matter accumulation compared to other varieties. It also recorded a maximum grain yield, no. of effective tillers, no of grains per spike, and 1000 grain weight. This was followed by the variety BH-393 and RD-2035 performed poorly. In terms of economics KBS-D-341 obtained maximum net returns of (Rs. 88887.05 ha-1) with a BC ratio of (2.11) at 80kg N ha-1 as compared to other varieties.
6
Rahma Nuryanti, Ineke Febrina Anggraini, Dian Kurnia Sari i Sonya. "UJI KUALITAS BAHAN BAKAR BIODIESEL DARI MINYAK JELANTAH ( PENGGORENGAN PECEL LELE) DENGAN PARAMETER UJI SPESIFIC GRAVITY 60/60 ˚F ASTM D-1298, DISTILASI ASTM D-86, VISKOSITAS KINEMATIK ASTM D-445, FLASH POINT PM ASTM D-93, POUR POINT ASTM D-97 DAN CETANE". Jurnal Cakrawala Ilmiah 3, nr 1 (25.09.2023): 229–36. http://dx.doi.org/10.53625/jcijurnalcakrawalailmiah.v3i1.6538.
Pełny tekst źródłaStreszczenie:
Biodiesel refers to one alternative fuel replacing diesel fuel obtained from renewable materials such as vegetable oil / animal fats (cooking oil). Used cooking oil is cooking oil which has been repeatedly used. Repeated use of cooking oil is by cause harm to the consumers. One of the utilizations of used cooking oil is by converting it into biodiesel. This study aims ti find out the process of converting used cooking oil into biodiesel and to investigate the quality of biodiesel produced from converted used cooking oil based on the parameters of Spesific gravity 60/60˚ F ASTM D-1298, distillation ASTM D-86, kinematic viscosity ASTM D-445, flash point ASTM D-93, pour point ASTM D-97, and cetane index ASTM D-4737. The process of making biodiesel from used cooking oil was conducted by two processes, namely esterification dan transesterification. On the process of esterification, ratio of used cooking oil and methanol was 1:2 and H2SO4 as the catalyst. On the process transesterification, on the other hand, the ratio of oil resulted from ester and methanol was 1:2 with NaOH as catalyst. Based on the analysis resul, Spesific gravity 60/60˚ F test showed 0.8562, 0.8569, 0.8569 (on specs), distillation on temperature 90% werw 340, 351 and 341 (on specs), kinematic viscosity resul showed 1,98 (off specs), flash point PM was 130˚ C, and 132˚ C (on specs), pour point result were 15˚ C, 17˚ C and 17˚ C (on specs), and cetane index result showed 51, 52, 51,5 (on specs).
7
Tomita, M., L. Xin, B. Freeman, S. Twomey, G. Pizzorno i J. R. Murren. "Pharmacokinetic and pharmacodynamic analysis of topotecan administered in combination with PS 341 in patients with advanced malignancy". Journal of Clinical Oncology 24, nr 18_suppl (20.06.2006): 2033. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.2033.
Pełny tekst źródłaStreszczenie:
2033 Background: In vitro exposure to camptothecin results in down-regulation of the target enzyme, topoisomerase I (topo) via multi-ubiquitination and proteasomal degradation of the protein-linked DNA breaks. To prevent loss of topo, and thus circumvent a possible mechanism of resistance to the topo inhibitors, we conducted a dose escalating phase I study of topotecan in combination with the proteosome inhibitor PS 341. We now report the pharmacokinetic and pharmacodynamic analysis of the trial. Methods: Patients with advanced cancer were treated with topotecan alone at the following dose escalating levels: 0.75, 1.0,1,25 and 1.5 mg/m2 as a 60 min infusion d x 5 during cycle 1. In subsequent cycles (21 days), cohorts of 3–6 patients received PS 341 as a 30 min infusion on days 1, 4, 8 and 11 at the following dose levels: 0.6, 0.8, 1.0 and 1.3 mg/m2. Topo expression was determined by western blot on peripheral blood mononuclear cells (PBMCs) sampled throughout the first 5-day treatment period of cycles #1 and 2. Total topotecan plasma pharmacokinetics were studied with the first doses of topotecan on cycle #1 (topotecan alone) and cycle #2 (topotecan after PS 341). Results: Samples were collected from 22 patients and 38 patient-cycles. In the first week of cycle #1, 9 of 22 (41 %) patients demonstrated a significant decrease in topo expression (range 0.2 - 1 fold) compared with the baseline level. Topo levels did not change (7/22, 32%) or increased (6/22, 27%) in the remaining patients. After administration of PS 341 during cycle #2, PBMC from 10 of 17 patients (59 %) analyzed showed a greater than 0.3 fold increase (range: 0.32 to 63) in topo concentration, and topo levels in 4 patients (23 %) were unchanged. Preliminary pharmacokinetic analysis indicates that PS 341 may interact with topotecan. Conclusions: There is a heterogeneous response in PBMC topo levels following administration of topotecan. However, addition of PS 341 to topotecan stabilized or increased PBMC topo I levels in the majority of patients, suggesting a possible role for PS341 in inhibiting camptothecin-induced topo protein degradation. Further studies combining proteasome inhibitors with topotecan to overcome drug resistance based on topo degradation are warranted. No significant financial relationships to disclose.
8
Lyas, Colin. "Faith After Foundationalism By D. Z. Phillips London: Routledge, 1988, xviii + 341 pp., £40". Philosophy 64, nr 249 (lipiec 1989): 419–21. http://dx.doi.org/10.1017/s0031819100044776.
Pełny tekst źródła
9
Marwaha, Raman K., Mahendra K. Garg, Gomathy Sethuraman, Nandita Gupta, Ambrish Mithal, Navin Dang, Mani Kalaivani i in. "Impact of three different daily doses of vitamin D3supplementation in healthy schoolchildren and adolescents from North India: a single-blind prospective randomised clinical trial". British Journal of Nutrition 121, nr 5 (29.01.2019): 538–48. http://dx.doi.org/10.1017/s0007114518003690.
Pełny tekst źródłaStreszczenie:
AbstractIn India, there is a lack of information about the adequate daily dose of vitamin D3supplementation in school children. Hence, we undertook this study to evaluate the adequacy and efficacy of different doses of vitamin D3in schoolchildren. A total of 1008 vitamin D-deficient (VDD) children, aged 6–16 years with serum 25-hydroxyvitamin D (25(OH)D) levels <50nmol/l, were cluster randomised into three groups (A-344, B-341 and C-232) for supplementation (600, 1000 and 2000 IU daily) of vitamin D3under supervision for 6 months. Of the 1008 subjects who completed the study, 938 (93 %) were compliant. Baseline and post-supplementation fasting blood and urine samples were evaluated for Ca, phosphates, alkaline phosphatase, 25(OH)D and parathormone and urine Ca:creatinine ratio. The mean age of the subjects was 11·7 (sd2·4) years, and the overall mean baseline serum 25(OH)D level was 24·3 (SD9·5)nmol/l. Post-supplementation rise in serum 25(OH)D in compliant group was maximum with 2000 IU (70·0 (SD30·0)nmol/l), followed by 1000 IU (46·8 (SD22·5)nmol/l) and 600 IU (36·5 (SD18·5)nmol/l), and serum 25(OH)D levels of ≥50nmol/l were achieved in 71·5, 81·8 and 92·9 % by groups A, B and C, respectively. Secondary hyperparathyroidism decreased from 31·7 to 8·4 % post-supplementation. Two participants developed hypercalciuria, but none developed hypercalcaemia. Children with VDD benefit maximum with the daily supplementation of 2000 IU of vitamin D3. Whether recommendations of 400 IU/d by Indian Council of Medical Research or 600 IU by Indian Academy of Pediatrics or Institute of Medicine would suffice to achieve vitamin D sufficiency in children with VDD remains debatable.
10
Li, Ruijuan, Yanqin Cao i Xinhong Zhang. "On kernels by rainbow paths in arc-coloured digraphs". Open Mathematics 19, nr 1 (1.01.2021): 268–83. http://dx.doi.org/10.1515/math-2021-0019.
Pełny tekst źródłaStreszczenie:
Abstract In 2018, Bai, Fujita and Zhang [Discrete Math. 341 (2018), no. 6, 1523–1533] introduced the concept of a kernel by rainbow paths (for short, RP-kernel) of an arc-coloured digraph D D , which is a subset S S of vertices of D D such that ( a a ) there exists no rainbow path for any pair of distinct vertices of S S , and ( b b ) every vertex outside S S can reach S S by a rainbow path in D D . They showed that it is NP-hard to recognize whether an arc-coloured digraph has an RP-kernel and it is NP-complete to decide whether an arc-coloured tournament has an RP-kernel. In this paper, we give the sufficient conditions for the existence of an RP-kernel in arc-coloured unicyclic digraphs, semicomplete digraphs, quasi-transitive digraphs and bipartite tournaments, and prove that these arc-coloured digraphs have RP-kernels if certain “short” cycles and certain “small” induced subdigraphs are rainbow.
11
Soto, Díaz. "Manzanero, D.: El legado jurídico y social de Giner. Madrid: Universidad Pontificia Comillas, 2016, 341 pp." Araucaria, nr 38 (2017): 579–87. http://dx.doi.org/10.12795/araucaria.2017.i38.26.
Pełny tekst źródła
12
Lu, Q., L. L. Wallrath, H. Granok i S. C. Elgin. "(CT)n (GA)n repeats and heat shock elements have distinct roles in chromatin structure and transcriptional activation of the Drosophila hsp26 gene". Molecular and Cellular Biology 13, nr 5 (maj 1993): 2802–14. http://dx.doi.org/10.1128/mcb.13.5.2802-2814.1993.
Pełny tekst źródłaStreszczenie:
Previous analysis of the hsp26 gene of Drosophila melanogaster has shown that in addition to the TATA box and the proximal and distal heat shock elements (HSEs) (centered at -59 and -340, relative to the start site of transcription), a segment of (CT)n repeats at -135 to -85 is required for full heat shock inducibility (R.L. Glaser, G.H. Thomas, E.S. Siegfried, S.C.R. Elgin, and J.T. Lis, J. Mol. Biol. 211:751-761, 1990). This (CT)n element appears to contribute to formation of the wild-type chromatin structure of hsp26, an organized nucleosome array that leaves the HSEs in nucleosome-free, DNase I-hypersensitive (DH) sites (Q. Lu, L.L. Wallrath, B.D. Allan, R.L. Glaser, J.T. Lis, and S.C.R. Elgin, J. Mol. Biol. 225:985-998, 1992). Inspection of the sequences upstream of hsp26 has revealed an additional (CT)n element at -347 to -341, adjacent to the distal HSE. We have analyzed the contribution of this distal (CT)n element (-347 to -341), the proximal (CT)n element (-135 to -85), and the two HSEs both to the formation of the chromatin structure and to heat shock inducibility. hsp26 constructs containing site-directed mutations, deletions, substitutions, or rearrangements of these sequence elements have been fused in frame to the Escherichia coli lacZ gene and reintroduced into the D. melanogaster genome by P-element-mediated germ line transformation. Chromatin structure of the transgenes was analyzed (prior to gene activation) by DNase I or restriction enzyme treatment of isolated nuclei, and heat-inducible expression was monitored by measuring beta-galactosidase activity. The results indicate that mutations, deletions, or substitutions of either the distal or the proximal (CT)n element affect the chromatin structure and heat-inducible expression of the transgenes. These (CT)n repeats are associated with a nonhistone protein(s) in vivo and are bound by a purified Drosophila protein, the GAGA factor, in vitro. In contrast, the HSEs are required for heat-inducible expression but play only a minor role in establishing the chromatin structure of the transgenes. Previous analysis indicates that prior to heat shock, these HSEs appear to be free of protein. Our results suggest that GAGA factor, an abundant protein factor required for normal expression of many Drosophila genes, and heat shock factor, a specific transcription factor activated upon heat shock, play distinct roles in gene regulation: the GAGA factor establishes and/or maintains the DH sites prior to heat shock induction, while the activated heat shock factor recognizes and binds HSEs located within the DH sites to trigger transcription.
13
Lu, Q., L. L. Wallrath, H. Granok i S. C. Elgin. "(CT)n (GA)n repeats and heat shock elements have distinct roles in chromatin structure and transcriptional activation of the Drosophila hsp26 gene." Molecular and Cellular Biology 13, nr 5 (maj 1993): 2802–14. http://dx.doi.org/10.1128/mcb.13.5.2802.
Pełny tekst źródłaStreszczenie:
Previous analysis of the hsp26 gene of Drosophila melanogaster has shown that in addition to the TATA box and the proximal and distal heat shock elements (HSEs) (centered at -59 and -340, relative to the start site of transcription), a segment of (CT)n repeats at -135 to -85 is required for full heat shock inducibility (R.L. Glaser, G.H. Thomas, E.S. Siegfried, S.C.R. Elgin, and J.T. Lis, J. Mol. Biol. 211:751-761, 1990). This (CT)n element appears to contribute to formation of the wild-type chromatin structure of hsp26, an organized nucleosome array that leaves the HSEs in nucleosome-free, DNase I-hypersensitive (DH) sites (Q. Lu, L.L. Wallrath, B.D. Allan, R.L. Glaser, J.T. Lis, and S.C.R. Elgin, J. Mol. Biol. 225:985-998, 1992). Inspection of the sequences upstream of hsp26 has revealed an additional (CT)n element at -347 to -341, adjacent to the distal HSE. We have analyzed the contribution of this distal (CT)n element (-347 to -341), the proximal (CT)n element (-135 to -85), and the two HSEs both to the formation of the chromatin structure and to heat shock inducibility. hsp26 constructs containing site-directed mutations, deletions, substitutions, or rearrangements of these sequence elements have been fused in frame to the Escherichia coli lacZ gene and reintroduced into the D. melanogaster genome by P-element-mediated germ line transformation. Chromatin structure of the transgenes was analyzed (prior to gene activation) by DNase I or restriction enzyme treatment of isolated nuclei, and heat-inducible expression was monitored by measuring beta-galactosidase activity. The results indicate that mutations, deletions, or substitutions of either the distal or the proximal (CT)n element affect the chromatin structure and heat-inducible expression of the transgenes. These (CT)n repeats are associated with a nonhistone protein(s) in vivo and are bound by a purified Drosophila protein, the GAGA factor, in vitro. In contrast, the HSEs are required for heat-inducible expression but play only a minor role in establishing the chromatin structure of the transgenes. Previous analysis indicates that prior to heat shock, these HSEs appear to be free of protein. Our results suggest that GAGA factor, an abundant protein factor required for normal expression of many Drosophila genes, and heat shock factor, a specific transcription factor activated upon heat shock, play distinct roles in gene regulation: the GAGA factor establishes and/or maintains the DH sites prior to heat shock induction, while the activated heat shock factor recognizes and binds HSEs located within the DH sites to trigger transcription.
14
Zhou, Huan-Huan, Xin-Li Zheng, Tian-Ming Ma, Meng Qi, Zong-Xi Cao, Zhe Chao, Li-Min Wei i in. "Genotype identification and phylogenetic analysis of Enterocytozoon bieneusi in farmed black goats (Capra hircus) from China’s Hainan Province". Parasite 26 (2019): 62. http://dx.doi.org/10.1051/parasite/2019064.
Pełny tekst źródłaStreszczenie:
Enterocytozoon bieneusi is an important pathogen commonly found in humans and animals. Farmed animals with close contact to humans are important hosts of E. bieneusi. The role of goats in the transmission of E. bieneusi, however, remains unclear. In this study, 341 fresh fecal samples of black goats were collected from five locations in Hainan Province, China. Enterocytozoon bieneusi was identified and genotyped by sequences of the internal transcribed spacer (ITS) region. Phylogenetic analysis was performed by constructing a neighbor-joining tree of the ITS gene sequences. The average prevalence of E. bieneusi in black goats was 24.0% (82/341) with rates ranging from 6.3% (4/63) to 37.2% (32/86) across the locations (χ2 = 17.252, p < 0.01). Eight genotypes of E. bieneusi were identified, including six known genotypes: CHG5 (n = 47); CHG3 (n = 23); CHG2 (n = 4); CM21 (n = 3); D (n = 2); and AHG1 (n = 1), and two novel genotypes termed HNG-I (n = 1) and HNG-II (n = 1). In the phylogenetic tree, genotype D was clustered into Group 1 and the other identified genotypes were included in Group 2. This represents the first report identifying E. bieneusi in black goats from Hainan Province, with a high prevalence and wide occurrence demonstrated. The two new genotypes identified provide additional insights into the genotypic variations in E. bieneusi. Due to the small percentage of zoonotic genotypes in these animals, there is minimal risk of zoonotic transmission of E. bieneusi.
15
Chasiotis, Vasilis, Stratis Kounias i Nikos Farmakis. "Corrigendum to “The D-optimal saturated designs of order 22” [Discrete Math. 341 (2018) 380–387]". Discrete Mathematics 342, nr 7 (lipiec 2019): 2161. http://dx.doi.org/10.1016/j.disc.2018.12.003.
Pełny tekst źródła
16
Radhakrishnan, Ramkumar. "A study on the Friedmann-like Universe with torsion using Noether symmetry". Modern Physics Letters A 35, nr 06 (12.11.2019): 2050027. http://dx.doi.org/10.1142/s0217732320500273.
Pełny tekst źródłaStreszczenie:
This paper deals with the symmetry analysis of the Einstein Cartan Theory [E. Cartan, C. R. Acad. Sci. (Paris) 174, 593 (1922); E. Cartan, Ann. Sci. Ec. Norm. Super 40, 325 (1923)] which is an extension of the general relativity and it accounts for the spacetime torsion [S. Basilakos et al., Phys. Rev. D 88, 103526 (2013)]. We begin by applying Noether theorem [S. Capozziello, La Rivista del Nuovo Cimento (1978–1999) 19(4), 1 (1996)] to the Lagrangian of the FRW type cosmology with torsion and choose a point transformation: [Formula: see text], such that one of the transformed variables is cyclic [S. Capozziello, M. De Laurentis and S. D. Odintsov, Eur. Phys. J. C 72, 2068 (2012)] for the Lagrangian. Then using the conserved charge [S. Capozziello, M. De Laurentis and S. D. Odintsov, Eur. Phys. J. C 72, 2068 (2012)], which is obtained by applying Noether theorem, and the constant of motion, we get the solutions and conclude that due to the presence of torsion, the FRW type cosmology is in the de Sitter phase [D. Kranas, C. G. Tsagas, J. D. Barrow and D. Iosifidis, Eur. Phys. J. C 79, 341 (2019)].
17
Else, P. L. "Plasma potassium may protect sodium pumps of toad hearts from an endogenous inhibitor". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 267, nr 3 (1.09.1994): R754—R761. http://dx.doi.org/10.1152/ajpregu.1994.267.3.r754.
Pełny tekst źródłaStreszczenie:
Resibufogenin (3-hydroxy-14,15-epoxy-20,22-dienolide glycoside) is a potent sodium pump inhibitor present in toad toxin. It is present in the skin of the cane toad (Bufo marinus) at a concentration equivalent to ouabain of approximately 1 mM. Because toads, like other amphibians, have permeable skin, resibufogenin is also found in high concentrations in the blood. In the cane toad the blood concentration is estimated to be 1 microM (D. Lichtstein, S. Kachalsky, and J. Deutsch. Life Sci. 38: 1261-1270, 1986; D. Lichtstein, S. Samuelov, J. Deutsch, H. Xu, R. A. Lutz, S. S. Chernick and S. S. Chernick. Klin. Wochenschr. 65, Suppl. 8: 40-48, 1987), a concentration thousands of times that required to produce toxicity in humans (J. S. Flier, E. Matatos-Flier, J. A. Pallotta, and D. McIsaac. Nature Lond. 279: 341-343, 1979). In examining how the cane toad avoids inhibiting its own sodium pumps, work on the heart showed that 1) cane toads possess a similar number of cardiac sodium pumps as other vertebrates, and 2) normal plasma K+ levels completely prevent ouabain, and presumably resibufogenin, from binding to cardiac sodium pumps of the cane toad. Other species, i.e., rat (Rattus norvegicus) and salamander (Ambystoma mexicanum), did not show K+ protection of their cardiac ouabain binding sites up to normal plasma K+ levels. These species do not possess the high level of endogenous ouabain-like substance found in the toad. K+ demonstrated a capacity to protect the enzymatic activity of the toad heart sodium pumps from the inhibitory effects of ouabain.
18
Jiang, Ning, Yuan Yang, Bingkun Yang i Wenli Huang. "VENTURE CAPITAL AND CORPORATE INNOVATION INPUT FROM THE PERSPECTIVE OF SYNDICATED INVESTMENT". Buletin Ekonomi Moneter dan Perbankan 22, nr 1 (30.04.2019): 29–46. http://dx.doi.org/10.21098/bemp.v22i1.1036.
Pełny tekst źródłaStreszczenie:
Using data for 341 enterprises listed on the Growth Enterprise Market (GEM) of the Shenzhen Stock Exchange and taking R&D expenditure as an indicator of innovation investment, this paper implements multiple linear regression to test whether venture capital promotes corporate innovation input. It also considers the relationship between the syndicated investment of venture capital and innovation input. The results showthat venture capital indeed promotes R&D in the invested enterprises. The innovation input of syndicated investment enterprises is significantly higher than that of sole investment enterprises. Under syndicated investment, the higher the number of syndicated investment members and the greater the heterogeneity of the shareholding ratio among the members, the higher is the innovation input. The reputation of the syndicated investment team, however, has no significant impact on innovation input.
19
He, Zhuoling, i Junyun Zhang. "Compaction Quality Inspection Method of Soil-Rock Filled Embankment Based on Continuous Compaction Control Technology". Advances in Civil Engineering 2021 (8.01.2021): 1–12. http://dx.doi.org/10.1155/2021/8894042.
Pełny tekst źródłaStreszczenie:
Affected by the site construction conditions, the measurement passes of the Taihang Expressway K8 + 105 ∼ K8 + 341 (K8 worksite) in the Taihang Expressway did not meet the requirements of data analysis, and the quantity of the control points was insufficient so that the linear correlation between the dynamic deformation modulus () and the vibratory compaction value (VCV) was not strong. Therefore, the target value of VCV cannot be used to diagnose the E v d compaction quality of soil-rock filler. This paper analyzes the roller measurement VCV value and in situ measurements E v d value separately. Results reveal the difference between the VCV mean measured in the last two passes and the standard deviation of the measured VCV mean in the last pass are used as the main basis for the actual compaction quality. In addition, the E v d mean in the last rolling can be used as an auxiliary judgment basis for the quality control of the compaction.
20
Journal, Baghdad Science. "Gene frequencies of ABO and rhesus blood groups in Sabians (Mandaeans), Iraq". Baghdad Science Journal 11, nr 2 (1.06.2014): 1035–42. http://dx.doi.org/10.21123/bsj.11.2.1035-1042.
Pełny tekst źródłaStreszczenie:
The present study aimed to determine the frequency of ABO and Rh blood group antigens among Sabians (Mandaeans) population. This paper document the frequency of ABO and Rh blood groups among the Sabians (Mandaeans) population of Iraq.There is no data available on the ABO/Rh (D) frequencies in the Sabians (Mandaeans) population. Total 341 samples analyzed; phenotype O blood type has the highest frequency 49.9%, followed by A 28.7%, and B 13.8% whereas the lowest prevalent blood group was AB 7.6%. The overall phenotypic frequencies of ABO blood groups were O>A>B>AB. The allelic frequencies of O, A, and B alleles were 0.687, 0.2 and 0.1122 respectively. Rhesus study showed that with a percentage of 96.2% Rh (D) positive is by far the most prevalent, while Rh (d) negative is present only in 3.8% of the total population. The Sabians (Mandaeans) ethnic group showed the same distribution of ABO and Rh blood groups with others ethnic groups in Iraqi population.
21
SIMONIC, Tatjana, Stefano DUGA, Armando NEGRI, Gabriella TEDESCHI, Massimo MALCOVATI, Maria L. TENCHINI i Severino RONCHI. "cDNA cloning and expression of the flavoprotein d-aspartate oxidase from bovine kidney cortex". Biochemical Journal 322, nr 3 (15.03.1997): 729–35. http://dx.doi.org/10.1042/bj3220729.
Pełny tekst źródłaStreszczenie:
The isolation and sequencing of the complete cDNA coding for a d-aspartate oxidase, as well as the overexpression of the recombinant active enzyme, are reported for the first time. This 2022 bp cDNA, beside the coding portion, comprises a 5´ untranslated tract and the whole 3´ region including the polyadenylation signal and the poly(A) tail. The encoded protein comprises 341 amino acids, with the last three residues (-Ser-Lys-Leu) representing a peroxisomal targeting signal 1 (PTS1), hitherto unknown for this protein. The overexpression of recombinant d-aspartate oxidase was achieved in a prokaryotic system, and a soluble and active enzyme was obtained which accounted for about 10% of total bacterial protein. Comparisons with the known cDNAs for mammalian d-amino acid oxidase, another peroxisomal enzyme, are also made. The close structural and functional similarities shared by these enzymes at the protein level are not reflected at the nucleic acid level.
22
He, Zhuoling, i Junyun Zhang. "Compaction Quality Inspection Method of Soil-Rock Filled Embankment Based on Continuous Compaction Control Technology". Advances in Civil Engineering 2021 (8.01.2021): 1–12. http://dx.doi.org/10.1155/2021/8894042.
Pełny tekst źródłaStreszczenie:
Affected by the site construction conditions, the measurement passes of the Taihang Expressway K8 + 105 ∼ K8 + 341 (K8 worksite) in the Taihang Expressway did not meet the requirements of data analysis, and the quantity of the control points was insufficient so that the linear correlation between the dynamic deformation modulus () and the vibratory compaction value (VCV) was not strong. Therefore, the target value of VCV cannot be used to diagnose the E v d compaction quality of soil-rock filler. This paper analyzes the roller measurement VCV value and in situ measurements E v d value separately. Results reveal the difference between the VCV mean measured in the last two passes and the standard deviation of the measured VCV mean in the last pass are used as the main basis for the actual compaction quality. In addition, the E v d mean in the last rolling can be used as an auxiliary judgment basis for the quality control of the compaction.
23
Facon, Thierry, Gordon Cook, Saad Z. Usmani, Cyrille Hulin, Shaji Kumar, Torben Plesner, Cyrille Touzeau i in. "Daratumumab plus lenalidomide and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: frailty subgroup analysis of MAIA". Leukemia 36, nr 4 (2.01.2022): 1066–77. http://dx.doi.org/10.1038/s41375-021-01488-8.
Pełny tekst źródłaStreszczenie:
AbstractIn the phase 3 MAIA study of patients with transplant-ineligible newly diagnosed multiple myeloma (NDMM), daratumumab plus lenalidomide/dexamethasone (D-Rd) improved progression-free survival (PFS) versus lenalidomide/dexamethasone (Rd). We present a subgroup analysis of MAIA by frailty status. Frailty assessment was performed retrospectively using age, Charlson comorbidity index, and baseline Eastern Cooperative Oncology Group performance status score. Patients were classified as fit, intermediate, non-frail (fit + intermediate), or frail. Of the randomized patients (D-Rd, n = 368; Rd, n = 369), 396 patients were non-frail (D-Rd, 196 [53.3%]; Rd, 200 [54.2%]) and 341 patients were frail (172 [46.7%]; 169 [45.8%]). After a 36.4-month median follow-up, non-frail patients had longer PFS than frail patients, but the PFS benefit of D-Rd versus Rd was maintained across subgroups: non-frail (median, not reached [NR] vs 41.7 months; hazard ratio [HR], 0.48; P < 0.0001) and frail (NR vs 30.4 months; HR, 0.62; P = 0.003). Improved rates of complete response or better and minimal residual disease (10–5) negativity were observed for D-Rd across subgroups. The most common grade 3/4 treatment-emergent adverse event in non-frail and frail patients was neutropenia (non-frail, 45.4% [D-Rd] and 37.2% [Rd]; frail, 57.7% and 33.1%). These findings support the clinical benefit of D-Rd in transplant-ineligible NDMM patients enrolled in MAIA, regardless of frailty status.
24
Lamping, K. G., i W. P. Dole. "Flow-mediated dilation attenuates constriction of large coronary arteries to serotonin". American Journal of Physiology-Heart and Circulatory Physiology 255, nr 6 (1.12.1988): H1317—H1324. http://dx.doi.org/10.1152/ajpheart.1988.255.6.h1317.
Pełny tekst źródłaStreszczenie:
We tested the hypothesis that flow-mediated endothelium-dependent dilation can attenuate humorally mediated constriction of large coronary arteries in vivo. Accordingly, we measured constriction of large coronary arteries to serotonin when flow was allowed to increase and when flow was constant in the presence and absence of endothelium. The left anterior descending coronary artery of anesthetized dogs was perfused at constant pressure (100 mmHg) and diameter measured with an ultrasonic dimension gauge. Coronary flow was measured with an in-line electromagnetic flow probe. Flow-mediated dilation was demonstrated by measuring diameter (D) after increased flow in response to adenosine (1 mg/min ic). Adenosine (n = 9) increased flow (341 +/- 69%) and resulted in large artery dilation [diameter change (delta D) = 101 +/- 54 microns], which was abolished by maintaining constant flow (distal snare) or by removing endothelium. Serotonin (n = 9, 50 micrograms/min ic) increased flow (298 +/- 45%) while simultaneously decreasing large artery diameter (delta D = -58 +/- 22 microns). When flow was kept constant, serotonin produced a greater constriction (delta D = -173 +/- 29 microns). After the removal of endothelium (n = 10), constrictor responses to serotonin were similar when flow increased (delta D = -84 +/- 13 microns) and when flow was kept constant (delta D = -79 +/- 23 microns). We conclude that flow-mediated dilation of large coronary arteries can attenuate constriction to serotonin and that this effect is dependent on endothelium.
25
Wei, J., T. Jaleel, A. MacLeod i J. S. Ji. "341 Association between vitamin D and eczema among adults in the US National Health and Nutrition Examination Survey". Journal of Investigative Dermatology 138, nr 5 (maj 2018): S58. http://dx.doi.org/10.1016/j.jid.2018.03.347.
Pełny tekst źródła
26
Kulkarni, R. N., D. M. Smith, M. A. Ghatei, P. M. Jones i S. R. Bloom. "Investigation of the effects of antisense oligodeoxynucleotides to islet amyloid polypeptide mRNA on insulin release, content and expression". Journal of Endocrinology 151, nr 3 (grudzień 1996): 341–48. http://dx.doi.org/10.1677/joe.0.1510341.
Pełny tekst źródłaStreszczenie:
Abstract We have investigated the effects of antisense oligodeoxynucleotides (oligos) to islet amyloid polypeptide (IAPP) mRNA on the expression and secretion of IAPP and insulin, in the clonal β-cell line HIT-T15. Phosphorothioate-modified oligos were cytotoxic compared with phosphodiester (D)-oligos. Of the nine oligos tested using a lipofection reagent, 03, a 30-mer D-oligo complementary to a sequence downstream of the IAPP initiation codon, showed a significant dose-dependent suppression of IAPP mRNA, with a 42% decrease at 7·5 μm, compared with a scrambled (MS03) control oligo (n=3, P<0·01). A subsequent 89% suppression of IAPP release was observed in the 4-h period following antisense treatment (1·78 ± 0·13 (MS03) vs 0·19 ± 0·14 (03) pmol/106 cells per 240 min, n=7, P<0·01). A significant increase in insulin mRNA (100 ± 10% (MS03) vs 124 ± 8% (03), n=3, P<0·05) and insulin content (13·0 ± 0·9 (MS03) vs 17·4 ± 1·4 (03) pmol/106 cells, n=7, P=0·028) was observed following treatment with 03 at 7·5 μm. 08, a 20-mer D-oligo directed to a region of IAPP mRNA further downstream than 03, also showed a decrease in IAPP mRNA and peptide release and an increase in insulin content. No significant changes were observed in the expression and release of the unrelated β-cell peptide, neuropeptide Y. We thus show a suppression of synthesis and release of IAPP in HIT-T15 cells using antisense oligos. The associated increase in insulin mRNA and content in these cells after treatment with IAPP antisense oligos is in accord with an inhibitor action of IAPP on insulin availability. Journal of Endocrinology (1996) 151, 341–348
27
Khan, Amir Taj, Kalim Ullah Khan, Muhammad Ishfaq, Naveed Ahmad, Muhammad Khalid, Muhammad Zubair Khan i Izhar Ahmad. "Frequency of Vitamin D Deficiency among Patients Presenting with Stroke". Pakistan Journal of Medical and Health Sciences 16, nr 7 (30.07.2022): 731–33. http://dx.doi.org/10.53350/pjmhs22167731.
Pełny tekst źródłaStreszczenie:
Background: Stroke is the leading cause of both mortality and disability on a global scale. The documented incidence of cerebral hemorrhages at Pakistan's CT scan facilities varies from 31-40% of cases, whereas ischemic stroke is claimed to be responsible for 60-90% of cases Objectives: The objective of the study was to assess the prevalence of vitamin D deficiency in patients presenting with stroke Methodology: The current study was descriptive and cross-sectional carried out at the Medicine Department, Hayatabad Medical Complex Peshawar for duration of six months February 2018 to August 2018. Patients were enrolled from both the emergency and accident department and outpatient department. The blood samples were taken and transferred to the hospital diagnostic laboratory for the assessment of deficiency of vitamin D in serum. The data analysis was done by using IBM SPSS version 16. Results: In this study, totally 341 patients were enrolled. There were 239 (70.09%) male patients while female patients were 102 (29.91%). The vitamin D deficiency in serum was observed in 50.1% patients. Conclusion: Stroke is still a calamity, and vitamin D could have played pivotal role in the pathogenesis of stroke. Since most of our population is already deficiency in 25-hydroxyvitamin D, therefore, relationship between stroke and vitamin D deficiency cannot be studied at hospital settings. We recommend more analytical research projects not only at hospital level but also at community level to draw conclusions about the relationship between vitamin D status and occurrence of stroke. Keywords: Stroke, Cerebrovascular accident, acute ischemic stroke, hypertension, vitamin D, 25-hydroxyvitamin D
28
Li, Li, Xuemei He, Jian Sun, Changbao Li, Dongning Ling, Jinfeng Sheng, Xiangrong You i in. "Cloning, Characterization, and Functional Expression of Phospholipase Dα cDNA from Banana (Musa acuminate L.)". Journal of Food Quality 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/2510949.
Pełny tekst źródłaStreszczenie:
Phospholipase D (PLD) plays a key role in adaptive responses of postharvest fruits. A cDNA clone of banana (Musa acuminate L.) PLDα (MaPLDα) was obtained by RT-PCR in this study. The MaPLDα gene contains a complete open reading frame (ORF) encoding a 92-kDa protein composed of 832 amino acid residues and possesses a characteristic C2 domain and two catalytic H×K×××D (abbr. HKD) motifs. The two HKD motifs are separated by 341 amino acid residues in the primary structure. Relatively higher PLD activity and expression of MaPLDα mRNA were detected in developing tissues compared to senescent or mature tissues in individual leaves, flower, stem, and fruit organs, respectively. The expression profile of PLDα mRNA in postharvest banana fruits at different temperatures was determined, and the MaPLDα mRNA reached the highest expression peak on day 5 at 25°C and on day 7 at 12°C. The results provide useful information for maintaining postharvest quality and extending the storage life of banana fruit.
29
He, Aiwu Ruth, Benjamin R. Tan, Thatthan Suksombooncharoen, Hidenori Takahashi, Ming-Huang Chen, Vikas S. Ostwal, Sang Cheul Oh i in. "Outcomes by antibiotic use in participants with advanced biliary tract cancer treated with durvalumab or placebo plus gemcitabine and cisplatin in the phase 3 TOPAZ-1 study." Journal of Clinical Oncology 41, nr 4_suppl (1.02.2023): 550. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.550.
Pełny tekst źródłaStreszczenie:
550 Background: TOPAZ-1 (NCT03875235) is a double-blind, Phase 3 study of durvalumab (D), an immune checkpoint inhibitor (ICI), + gemcitabine and cisplatin (GC) in participants (pts) with advanced biliary tract cancer (BTC). D + GC improved overall survival (OS) in pts with advanced BTC versus placebo (PBO) + GC (Oh et al. NEJM Evid 2022). Use of antibiotics during ICI treatment has been correlated with poorer OS and progression-free survival (PFS; Jiang et al. Front Oncol 2022). Methods: Pts were randomized 1:1 to receive D (1500 mg) or PBO on Day 1 every 3 weeks (Q3W), + G (1000 mg/m2) and C (25 mg/m2) on Days 1 and 8 Q3W, for ≤8 cycles, followed by D or PBO monotherapy Q4W. This exploratory subgroup analysis of TOPAZ-1 assessed OS and PFS by systemic antibiotic use during the study (≥1 dose 14 days before first D/PBO dose to 14 days after last D/PBO dose). Hazard ratios (HRs) were estimated using an unstratified Cox proportional hazards model, adjusting for disease status (initially unresectable or recurrent) and primary tumor location (intrahepatic cholangiocarcinoma, extrahepatic cholangiocarcinoma, or gallbladder cancer). Data cut-off at primary analysis was Aug 11, 2021. Results: The number (%) of pts using antibiotics during the study (D + GC, 167/341 [49.0%]; PBO + GC, 167/344 [48.5%]) was similar between treatment arms. In the D + GC arm, median OS (95% CI) was similar regardless of antibiotics use: 12.6 (9.7–14.8) months in pts with antibiotics use vs 13.0 (10.8–14.7) months in pts without (Table). In the PBO + GC arm, median OS (95% CI) was 10.3 (8.7–12.5) in pts with antibiotics use vs 12.1 (11.0–13.8) in pts without. OS HRs (95% CI) in D + GC vs PBO + GC were 0.78 (0.59–1.02) in pts with antibiotics and 0.81 (0.62–1.07) in pts without. Median PFS (95% CI) was 7.3 (6.5–7.7) months in pts with antibiotics use vs 7.2 (5.9–7.4) months in pts without in the D + GC arm and 5.7 (5.4–6.6) months vs 6.1 (5.6–7.3) months, respectively, in the PBO + GC arm (Table). PFS HRs (95% CI) were 0.70 (0.55–0.89) in pts with antibiotics use and 0.82 (0.65–1.03) in pts without. Conclusions: In the TOPAZ-1 study of D in BTC, no meaningful difference was found in OS or PFS for participants who received antibiotics during the study period compared with those who did not, and results were consistent with the primary analysis. These results support that people receiving D may be treated with antibiotics when clinically indicated. Clinical trial information: NCT03875235 . [Table: see text]
30
Sands, Deanna J., Lois Adams i Donna M. Stout. "A Statewide Exploration of the Nature and Use of Curriculum in Special Education". Exceptional Children 62, nr 1 (wrzesień 1995): 68–83. http://dx.doi.org/10.1177/001440299506200106.
Pełny tekst źródłaStreszczenie:
This study reports the results of a statewide survey of the beliefs and practices, regarding curriculum, of 341 elementary and secondary special education teachers serving students with a variety of disabilities. Findings indicate that (a) teacher training in curriculum development occurs mostly on the job; (b) teachers want training in teaching compensatory skills and life skills; (c) teachers believe that the IEP constitutes the curriculum for students with disabilities; (d) teacher judgment primarily guides the content of classroom instruction; (e) teachers focus principally on academic remediation versus life-skill or other instruction; (f) curriculum focus varies little across service-delivery models, but does vary by grade level; and (g) minimal articulation of curriculum exists across grade levels.
31
Yusni, Yusni. "Calcidiol serum levels and blood pressure responses in normotensive patients with dietary goat milk". Bangladesh Journal of Medical Science 17, nr 3 (29.06.2018): 337–241. http://dx.doi.org/10.3329/bjms.v17i3.36986.
Pełny tekst źródłaStreszczenie:
Background: Calcidiol (25-hydroxyvitamin D or 25(OH) D) is the active form of vitamin D that can be measured in the blood. Vitamin D functions as a regulator of blood pressure and a vitamin D deficiency is associated with an increased risk of hypertension. Goat’s milk is thought to have anti hypertensive effect. That is likely due to the amount of vitamin D found in goat’s milk, but requires further investigation. This research was conducted to analyze the effect of consuming goat’s milk on blood pressure and its relationship with calcidiol serum in normotensive patients.Materials and Methods: The design of this research was experimental laboratory with randomized pretest-posttest with a control group using 18 sedentary women aged 18-19 years. The treatment was 250 ml/day of goat’s milk given in the morning after breakfast for 110 days. The data were analyzed by the statistical t-test (p<0.05).Results: A significant decrease of systolic blood pressure (p=0.00) and no significant decrease of diastolic blood pressure (p=0.51) were observed in the trial group. Levels of calcidiol serum did not increase significantly (p=0.06) after consuming goat’s milk in the trial group.Conclusion: It can be concluded that goat’s milk can decrease blood pressure but does not affect calcidiol serum in normotensive patients. Further research is needed to determine the effect of goat’s milk on blood pressure in hypertensive patients.Bangladesh Journal of Medical Science Vol.17(3) 2018 p.337-341
32
Zupo, Roberta, Fabio Castellana, Rodolfo Sardone, Luisa Lampignano, Carmen Di Noia, Silvia Savastano, Gianluigi Giannelli i Giovanni De Pergola. "Hydroxyvitamin D Serum Levels are Negatively Associated with Platelet Number in a Cohort of Subjects Affected by Overweight and Obesity". Nutrients 12, nr 2 (13.02.2020): 474. http://dx.doi.org/10.3390/nu12020474.
Pełny tekst źródłaStreszczenie:
Background: Hypovitaminosis D and higher platelet numbers are emerging as cardiovascular risk factors, in particular in obese subjects. Methods: This observational study was aimed at investigating the relationship between platelet number and serum 25-hydroxyvitamin D (25(OH)D) levels in a cohort of individuals affected by overweight and obesity (body mass index (BMI) ≥ 25 Kg/m2). A sample of 341 subjects (248 women, 93 men), aged 18–71 years, taking no medication, was examined. Anthropometric, hormone, metabolic and common routine hematochemical parameters were examined and evaluated in association with platelet count and serum 25(OH)D levels. Results: Platelet numbers were inversely related to age (p < 0.04), 25(OH)D (p < 0.05) and uric acid (p < 0.04) levels, and directly associated with white blood cells (p < 0.01), Thyroid Stimulating Hormone (TSH) (p < 0.04), insulin levels (p < 0.002) and Homeostasis Model Assessment – Insulin Resistance (HOMA-IR) (p < 0.002). We applied statistical regression models to examine the relationship between platelet count (dependent variable) and parameters that had univariate associations with platelet numbers, showing that the association between platelet count and 25(OH)D was not confirmed. Moreover, vitamin D showed a negative independent association with BMI, diastolic blood pressure and serum insulin levels. Conclusions: This study indicates, for the first time, that vitamin D deficiency is associated with a parallel increase in platelet number, suggesting that higher platelet numbers may be one of the possible mechanisms leading to a greater cardiovascular risk in obese subjects. It also shows that vitamin D deficiency, a common condition in obesity, has independent associations with higher BMI, diastolic blood pressure and serum insulin levels.
33
FELICIO, JOÃO CARLOS, CARLOS EDUARDO DE OLIVEIRA CAMARGO, ROGERIO GERMANI, JOSÉ GUILHERME DE FREITAS i ANTONIO WILSON PENTEADO FERREIRA-FILHO. "Rendimento de grãos e qualidade tecnológica de genótipos de trigo em três zonas tritícolas do Estado de São Paulo no biênio 1994-95". Bragantia 59, nr 1 (2000): 59–68. http://dx.doi.org/10.1590/s0006-87052000000100010.
Pełny tekst źródłaStreszczenie:
Foram avaliados o rendimento de grãos, a estabilidade e adaptabilidade ambiental, a tolerância ao alumínio tóxico e a qualidade tecnológica da farinha de vinte genótipos de trigo em três regiões tritícolas do Estado de São Paulo (Zonas A e B, sequeiro; Zona H, com irrigação por aspersão), no biênio 1994-95. Os resultados mostraram que: (a) os genótipos tiveram comportamento regional diferenciado quanto ao rendimento de grãos; (b) os genótipos IAC 289, IAC 340 e BR 18 mostraram-se, em média os mais produtivos, não diferindo do 'IAC 304', 'OCEPAR 14', 'IAC 350', 'Panda', 'IAC 60' e 'IAC 348'; (c) os genótipos apresentaram, em geral, boa estabilidade produtiva nas diferentes condições ambientais; (d) os genótipos IAC 289, IAC 340 e IAC 304 foram responsivos à melhoria ambiental e 'IAC 227', adaptado a ambientes desfavoráveis; (e) os genótipos IAC 24, IAC 120, IAC 227, OCEPAR 14, IAC 348, Panda, BR 18, IAC 319, IAC 346, IAPAR 60, IAC 332 e IAC 347 foram tolerantes à toxicidade de Al3+; (f) a farinha dos diferentes genótipos apresentou baixa atividade amilásica; (g) os genótipos IAC 340, IAC 227, IAC 319 e IAC 60 propiciaram farinha com baixos valores de W (energia de deformação da massa) e baixa estabilidade, características próprias de farinha de glúten fraco. Os demais genótipos revelaram característica de glúten forte.
34
Peponis, Marios, Maria Antoniadou, Eftychia Pappa, Christos Rahiotis i Theodoros Varzakas. "Vitamin D and Vitamin D Receptor Polymorphisms Relationship to Risk Level of Dental Caries". Applied Sciences 13, nr 10 (13.05.2023): 6014. http://dx.doi.org/10.3390/app13106014.
Pełny tekst źródłaStreszczenie:
Dental caries is a multifactorial disease with multiple risk factors. Vitamin D levels (VDLs) and vitamin D receptor polymorphisms (VDRPs) have been investigated for this reason. The aim of this narrative review is to investigate the relation and the factors affecting vitamin D deficiency (VDD), VDRP, Early Childhood Caries (ECC) and Severe Early Childhood Caries (S-ECC) in children (primary and mixed dentition) and dental caries risk in adults (permanent dentition). Additionally, we present a model incorporating factors and interactions that address this relationship. Methods: Three databases (PubMed/MEDLINE, Web of Science, Cochrane Library) were comprehensively searched until 17 January 2023 using the following keywords: “vitamin D”, “vitamin D receptor polymorphism”, “dental caries”, and “dental caries risk”, finding 341 articles. Two reviewers searched, screened, and extracted information from the selected articles. All pooled analyses were based on random-effects models. Eligibility criteria were articles using dmft/DMFT diagnostic criteria with calibrated examiners, probability sampling, and sample sizes. We excluded studies conducted on institutionalized patients. A total of 32 studies were finally used. Results: In most studies, TaqI, FokI, and BsmI polymorphisms affected the prevalence of dental caries. A strong correlation between ECC, S-ECC, and the prevalence of dental caries was reported in association with VDD and maternal intake of VD in primary dentition. Regarding the influence in mixed dentition, the results were found to be inconclusive. A slight positive influence was reported for permanent dentition. Conclusions: Factors affecting caries risk were maternal intake, socioeconomic factors, and level of VD. There is a certain need for more well-conducted studies that will investigate the association between VDR gene polymorphisms and the prevalence of dental caries in mixed and permanent dentition, specifically in adult patients.
35
Stoler, Genevieve B., James R. Johnston, Judy A. Stevenson i Joe Suyama. "Preparing Emergency Personnel in Dialysis: A Just-in-Time Training Program for Additional Staffing During Disasters". Disaster Medicine and Public Health Preparedness 7, nr 3 (czerwiec 2013): 272–77. http://dx.doi.org/10.1001/dmp.2011.34.
Pełny tekst źródłaStreszczenie:
AbstractBackgroundThere are 341 000 patients in the United States who are dependent on routine dialysis for survival. Recent large-scale disasters have emphasized the importance of disaster preparedness, including supporting dialysis units, for people with chronic disease. Contingency plans for staffing are important for providing continuity of care for a technically challenging procedure such as dialysis. PReparing Emergency Personnel in Dialysis (PREP-D) is a just-in-time training program designed to train individuals having minimum familiarity with the basic steps of dialysis to support routine dialysis staff during a disaster.MethodsA 5-module educational program was developed through a collaborative, multidisciplinary effort. A pilot study testing the program was performed using 20 nontechnician dialysis facility employees and 20 clinical-year medical students as subjects.ResultsWhen comparing pretest and posttest scores, the entire study population showed a mean improvement of 28.9%, with dialysis facility employees and medical students showing improvements of 21.8% and 36.4%, respectively (P < .05 for all comparisons).ConclusionsPREP-D participants were able to demonstrate improved tests scores when taught in a just-in-time training format. The knowledge gained by using the PREP-D program during a staffing shortage may allow for continuity of care for critical services such as dialysis during a disaster. (Disaster Med Public Health Preparedness. 2013;7:272-277).
36
Marques, Carlos, Sylvain Moreno, São Luís Castro i Mireille Besson. "Musicians Detect Pitch Violation in a Foreign Language Better Than Nonmusicians: Behavioral and Electrophysiological Evidence". Journal of Cognitive Neuroscience 19, nr 9 (wrzesień 2007): 1453–63. http://dx.doi.org/10.1162/jocn.2007.19.9.1453.
Pełny tekst źródłaStreszczenie:
The aim of this study was to determine whether musical expertise influences the detection of pitch variations in a foreign language that participants did not understand. To this end, French adults, musicians and nonmusicians, were presented with sentences spoken in Portuguese. The final words of the sentences were prosodically congruous (spoken at normal pitch height) or incongruous (pitch was increased by 35% or 120%). Results showed that when the pitch deviations were small and difficult to detect (35%: weak prosodic incongruities), the level of performance was higher for musicians than for nonmusicians. Moreover, analysis of the time course of pitch processing, as revealed by the event-related brain potentials to the prosodically congruous and incongruous sentence-final words, showed that musicians were, on average, 300 msec faster than nonmusicians to categorize prosodically congruous and incongruous endings. These results are in line with previous ones showing that musical expertise, by increasing discrimination of pitch—a basic acoustic parameter equally important for music and speech prosody—does facilitate the processing of pitch variations not only in music but also in language. Finally, comparison with previous results [Schön, D., Magne, C., & Besson, M. The music of speech: Music training facilitates pitch processing in both music and language. Psychophysiology, 41, 341–349, 2004] points to the influence of semantics on the perception of acoustic prosodic cues.
37
Baker, James F., Brian Dilworth, Samrath J. Bhimani, Kevin L. Ong, Edmund C. Lau, Langan S. Smith i Arthur L. Malkani. "Risk of Reinfection after Irrigation and Debridement of Acute Periprosthetic Joint Infection following TKA". Journal of Knee Surgery 33, nr 07 (25.03.2019): 623–28. http://dx.doi.org/10.1055/s-0039-1683920.
Pełny tekst źródłaStreszczenie:
AbstractThe purpose of this study was to determine the risk factors associated with reinfection in patients treated with irrigation and debridement (I&D) with liner exchange for an acute (less than 3 months) prosthetic joint infection following the index primary total knee arthroplasty (TKA). Medicare claims database was queried to identify patients with periprosthetic joint infection within 3 months of their index TKA who underwent I&D with tibial polyethylene liner exchange. Exclusion criteria included age < 65 years and < 1 year of claims prior to TKA. A total of 341 patients met our criteria and were analyzed by age, sex, diabetes, obesity, Charlson comorbidity score, and time between TKA and I&D with liner exchange. Average time to I&D with liner exchange following primary TKA was 38.5 ± 21.3 days and multivariate analysis showed a significantly higher risk of reinfection within 1 year in patients > 85 years old (p < 0.001) and diabetes (p < 0.02). The risk of reinfection was lowest for patients treated with I&D with liner exchange within 14 days after TKA (p = 0.028). The incidence of reinfection was 223% greater if I&D with liner exchange was performed 2 to 4 weeks after primary TKA (p < 0.03), and 277% higher if performed > 6 weeks after index procedure compared with those performed within 2 weeks. Patients older than 85 years, diabetics, or treated with I&D with liner exchange > 14 days following the primary TKA had a significantly higher risk of reinfection within 1 year. Patients should be cautioned on the risk of reinfection prior to proceeding with I&D with liner exchange > 2 weeks following the index procedure.
38
Brown, William P. "The Way of the Lord: Essays in Old Testament Theology: Patrick D. Miller: Grand Rapids: Eerdmans, 2007. 341 pp. $30.00". Theology Today 65, nr 4 (styczeń 2009): 499–501. http://dx.doi.org/10.1177/004057360906500408.
Pełny tekst źródła
39
Arnedo-Pena, A., J. V. Juan-Cerdán, M. Romeu-Garcia, S. Sorribes-Segura, M. Tirado-Balaguer, M. Gil-Fortuño, D. Garcia-Ferrer i in. "Vitamin D status and latent tuberculosis infection: conversion in nursing homes, Spain". International Journal of Tuberculosis and Lung Disease 24, nr 3 (1.03.2020): 278–86. http://dx.doi.org/10.5588/ijtld.19.0365.
Pełny tekst źródłaStreszczenie:
OBJECTIVE: To examine the potential association between vitamin D (VitD) deficiency and latent tuberculosis infection (LTBI) and its effect on TB infection conversion (TBIC) incidence.MATERIAL AND METHODS: We carried out a cross-sectional and prospective cohort study of nine pulmonary TB cases that occurred in 2015–2016 in five nursing homes and one mental disability institution in Castellon, Spain. QuantiFERON®-TB Gold and the tuberculin skin test were used to detect LTBI and TBIC, respectively. Serum 25-hydroxyvitamin D was measured using chemiluminescence immunoassay. Poisson regression and inverse probability weighting were used for statistical analyses.RESULTS: The study included 448 residents, 341 staff members with 48 relatives of TB cases (participation rate 82%): of these, respectively 122 (27.2%), 37 (10.9%) and 7 (14.6%) were LTBI-positive; and respectively 22 (7.7%), 10 (3.8%) and 1 (3.7%) were TBIC-positive. LTBI was not associated with VitD status. Severe VitD deficiency (SVDD; defined as VitD level < 10 ng/ml), found in 45.1% of residents, as well as VitD levels of <30 ng/ml (aRR 10.41 95% CI 1.48–73.26), were associated with increased TBIC risk (adjusted relative risk [aRR] 12.1, 95% CI 1.51–97.10), suggesting SVDD as a threshold effect. CONCLUSION: Severe VitD deficiency is a TBIC risk factor.
40
Shankar, Subbakrishna, Timothy J. Teyler i Norman Robbins. "Aging Differentially Alters Forms of Long-Term Potentiation in Rat Hippocampal Area CA1". Journal of Neurophysiology 79, nr 1 (1.01.1998): 334–41. http://dx.doi.org/10.1152/jn.1998.79.1.334.
Pełny tekst źródłaStreszczenie:
Shankar, Subbakrishna, Timothy J. Teyler, and Norman Robbins. Aging differentially alters forms of long-term potentiation in rat hippocampal area CA1. J. Neurophysiol. 79: 334–341, 1998. Long-term potentiation (LTP) of the Schaffer collateral/commissural inputs to CA1 in the hippocampus was shown to consist of N-methyl-d-aspartate receptor (NMDAR) and voltage-dependent calcium channel (VDCC) dependent forms. In this study, the relative contributions of these two forms of LTP in in vitro hippocampal slices from young (2 mo) and old (24 mo) Fischer 344 rats were examined. Excitatory postsynaptic potentials (EPSP) were recorded extracellularly from stratum radiatum before and after a tetanic stimulus consisting of four 200-Hz, 0.5-s trains given 5 s apart. Under control conditions, a compound LTP consisting of both forms was induced and was similar, in both time course and magnitude, in young and old animals. NMDAR-dependent LTP (nmdaLTP), isolated by the application of 10 μM nifedipine (a voltage-dependent calcium channel blocker), was significantly reduced in magnitude in aged animals. The VDCC dependent form (vdccLTP), isolated by the application of 50 μM d,l-2-amino-5-phosphonvalerate (APV), was significantly larger in aged animals. Although both LTP forms reached stable values 40–60 min posttetanus in young animals, in aged animals vdccLTP increased and nmdaLTP decreased during this time. In both young and old animals, the sum of the two isolated LTP forms approximated the magnitude of the compound LTP, and application of APV and nifedipine or genestein (a tyrosine kinase inhibitor) together blocked potentiation. These results suggest that aging causes a shift in synaptic plasticity from NMDAR-dependent mechanisms to VDCC-dependent mechanisms. The data are consistent with previous findings of increased L-type calcium current and decreased NMDAR number in aged CA1 cells and may help explain age-related deficits in learning and memory.
41
Fujishige, A., K. R. Smith, J. L. Silen i D. A. Agard. "Correct folding of alpha-lytic protease is required for its extracellular secretion from Escherichia coli." Journal of Cell Biology 118, nr 1 (1.07.1992): 33–42. http://dx.doi.org/10.1083/jcb.118.1.33.
Pełny tekst źródłaStreszczenie:
alpha-Lytic protease is a bacterial serine protease of the trypsin family that is synthesized as a 39-kD preproenzyme (Silen, J. L., C. N. McGrath, K. R. Smith, and D. A. Agard. 1988. Gene (Amst.). 69: 237-244). The 198-amino acid mature protease is secreted into the culture medium by the native host, Lysobacter enzymogenes (Whitaker, D. R. 1970. Methods Enzymol. 19:599-613). Expression experiments in Escherichia coli revealed that the 166-amino acid pro region is transiently required either in cis (Silen, J. L., D. Frank, A. Fujishige, R. Bone, and D. A. Agard. 1989. J. Bacteriol. 171:1320-1325) or in trans (Silen, J. L., and D. A. Agard. 1989. Nature (Lond.). 341:462-464) for the proper folding and extracellular accumulation of the enzyme. The maturation process is temperature sensitive in E. coli; unprocessed precursor accumulates in the cells at temperatures above 30 degrees C (Silen, J. L., D. Frank, A. Fujishige, R. Bone, and D. A. Agard. 1989. J. Bacteriol. 171:1320-1325). Here we show that full-length precursor produced at nonpermissive temperatures is tightly associated with the E. coli outer membrane. The active site mutant Ser 195----Ala (SA195), which is incapable of self-processing, also accumulates as a precursor in the outer membrane, even when expressed at permissive temperatures. When the protease domain is expressed in the absence of the pro region, the misfolded, inactive protease also cofractionates with the outer membrane. However, when the folding requirement for either wild-type or mutant protease domains is provided by expressing the pro region in trans, both are efficiently secreted into the extracellular medium. Attempts to separate folding and secretion functions by extensive deletion mutagenesis within the pro region were unsuccessful. Taken together, these results suggest that only properly folded and processed forms of alpha-lytic protease are efficiently transported to the medium.
42
Stadler, Zsofia K., Francesca Battaglin, Sumit Middha, Jaclyn F. Hechtman, Christina Tran, Andrea Cercek, Rona Yaeger i in. "Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels". Journal of Clinical Oncology 34, nr 18 (20.06.2016): 2141–47. http://dx.doi.org/10.1200/jco.2015.65.1067.
Pełny tekst źródłaStreszczenie:
Purpose Tumor screening for Lynch syndrome is recommended in all or most patients with colorectal cancer (CRC). In metastatic CRC, sequencing of RAS/BRAF is necessary to guide clinical management. We hypothesized that a next-generation sequencing (NGS) panel that identifies RAS/BRAF and other actionable mutations could also reliably identify tumors with DNA mismatch repair protein deficiency (MMR-D) on the basis of increased mutational load. Methods We identified all CRCs that underwent genomic mutation profiling with a custom NGS assay (MSK-IMPACT) between March 2014 and July 2015. Tumor mutational load, with exclusion of copy number changes, was determined for each case and compared with MMR status as determined by routine immunohistochemistry. Results Tumors from 224 patients with unique CRC analyzed for MMR status also underwent MSK-IMPACT. Thirteen percent (n = 28) exhibited MMR-D by immunohistochemistry. Using the 341-gene assay, 100% of the 193 tumors with < 20 mutations were MMR-proficient. Of 31 tumors with ≥ 20 mutations, 28 (90%) were MMR-D. The three remaining tumors were easily identified as being distinct from the MMR-D tumors with > 150 mutations each. Each of these tumors harbored the P286R hotspot POLE mutation consistent with the ultramutator phenotype. Among MMR-D tumors, the median number of mutations was 50 (range, 20 to 90) compared with six (range, 0 to 17) in MMR-proficient/POLE wild-type tumors (P < .001). With a mutational load cutoff of ≥ 20 and < 150 for MMR-D detection, sensitivity and specificity were both 1.0 (95% CI, 0.93 to 1.0). Conclusion A cutoff for mutational load can be identified via multigene NGS tumor profiling, which provides a highly accurate means of screening for MMR-D in the same assay that is used for tumor genotyping.
43
Oliveira, Dimas Estrasulas de, Marcelo de Queiroz Manella, Luis Orlindo Tedeschi, Sila Carneiro da Silva i Dante Pazzanese Duarte Lanna. "N-alkanes to estimate voluntary forage intake of cattle using controlled-release capsules". Scientia Agricola 65, nr 3 (2008): 230–38. http://dx.doi.org/10.1590/s0103-90162008000300002.
Pełny tekst źródłaStreszczenie:
N-alkanes have been used as internal markers in digestibility trials with ruminants and non-ruminants for more than 20 years. In this study, two trials were conducted under different feeding regimes to (i) evaluate the release rate of n-alkanes of controlled-release capsules in the rumen of rumen-cannulated steers either grazing or restrained in metabolic stalls and (ii) estimate voluntary forage intake of the same steers in metabolic stalls. Six rumen-cannulated Nelore steers were allocated to individual metabolic stalls and were fed diets with varying forage to concentrate ratios (80:20, 60:40, and 40:60; respectively). Corn silage was the only forage source. In the grazing trial, the same steers were evaluated under three feeding managements (Brachiaria brizantha cv. Marandu unsupplemented or supplemented with either 0.3% or 0.6% of live weight of a concentrate). The release rate of the n-alkanes (mg d-1) was measured by multiplying the distance (mm d-1) the capsule plunger travelled after 3, 7, 10, 13, and 17 d of rumen infusion to the n-alkanes concentration of capsule tablets (mg mm-1). There was an effect of day of measurement (P < 0.05) on the release rate of animals restrained in metabolic stalls and grazing. However, no effect (P > 0.05) of feeding management or feeding management x day of measurement interaction was observed. Values averaged 6.9 and 14.8%, lower than proposed by the manufacturer for the C32, when animals were restrained in metabolic stalls and at grazing, respectively. Similarly, the values of C36 were 15.9 and 23.1% lower for those animals in metabolic stalls and grazing, respectively. The average release rate of C32 into the rumen was 372 and 341 mg d-1 for animals restrained in metabolic stalls and grazing, respectively. There was no difference in the release rate between feeding regimes (P > 0.05). The regression of the pooled data indicated an average release rate of 345 mg d-1. Estimated values of voluntary forage intake using the pair of C33:C32 n-alkanes using the animals restrained in metabolic stalls was not different from those effectively measured (P > 0.05). These findings indicated that n-alkanes capsules can be used to estimate forage intake of stall-fed animals, but concentration of n-alkanes in capsules and the release rate has to be measured before dosing animals to accurately predict intake.
44
Bracken, G. K. "SUSCEPTIBILITY OF FIRST-INSTAR CABBAGE MAGGOT, DELIA RADICUM (L.) (ANTHOMYIIDAE: DIPTERA), TO STRAINS OF THE ENTOMOGENOUS NEMATODES STEINERNEMA FELTIAE FILIPJEV, S. BIBIONIS (BOVIEN), HETERORHABDITIS BACTERIOPHORA POINAR, AND H. HELIOTHIDIS (KHAN, BROOKS, AND HIRSCHMANN)". Canadian Entomologist 122, nr 4 (sierpień 1990): 633–39. http://dx.doi.org/10.4039/ent122633-7.
Pełny tekst źródłaStreszczenie:
AbstractThe susceptibility of first-instar cabbage maggot, Delia radicum (L.), to parasitism by seven strains or species of entomogenous nematodes was compared in Petri dishes lined with moist filter paper. The effective doses for 50% mortality (ED50) of the Mexican, Breton, and All strains of Steinernema feltiae Filipjev, of S. bibionis (Bovien), and of Heterorhabditis heliothidis (Khan, Brooks, and Hirschmann) ranged from 98 to 341 infective juveniles per host larva with overlapping 95% confidence intervals; the slopes ranged from 1.36 to 1.07. The DD136 strain of S. feltiae and the species H. bacteriophora Poinar were significantly less lethal with ED50 values of 1113 and 1719 nematodes per host larva, respectively. The addition of a thin disc of rutabaga into the test dishes increased ED50 values by a factor of 20 or more. Application of the Mexican strain of S. feltiae at 5 × 105 nematodes per plant to small caged field plots of rutabaga artificially infested with eggs of D radicum provided control similar to that with diazinon applied at 1.4 L AI per hectare. Practical control of D. radicum on rutabaga with entomogenous nematodes would require strains or species considerably more lethal than those tested here.
45
Oliveira, Solange Artimos de, Akira Homma, Léa Camillo-Coura, Maria Lucília P. Loureiro i Maria Teresa G. N. de Almeida. "Antimeasles antibodies in children submitted to different vaccination schedules". Revista da Sociedade Brasileira de Medicina Tropical 26, nr 2 (czerwiec 1993): 77–82. http://dx.doi.org/10.1590/s0037-86821993000200002.
Pełny tekst źródłaStreszczenie:
ln order to study the measles antibody behavior of three vaccination schedules, 684 children were divided into 4 Groups: Group A (341 vaccinated children under the age of one); Group B (101 children at the age of one); Group C (74 children under the age of one and one at the age of one); Group D (163 unvaccinated children with a history of measles in the past - Group control). Children of Group A presented lower rates and 25.9% of the age group under two did not show any measles antibodies. In Group B, all the children presented antibodies. In Group C onby 4.0% did not. In all age groups, the geometric mean HI antibody titers of Group A were lower than the valuesfound in the other groups. The age at vaccination was the factor of greater influence on the results of this study.
46
Shapira, I., Y. Goldin, O. Rogowski, P. Halpern, J. Serov i S. Berliner. "PO13-341 THE DIAGNOSTIC YIELD OF D-DIMER IN RELATION TO TIME FROM SYMPTOM ONSET IN PATIENTS EVALUATED FOR VENOUS THROMBOEMBOLISM". Atherosclerosis Supplements 8, nr 1 (czerwiec 2007): 101. http://dx.doi.org/10.1016/s1567-5688(07)71351-x.
Pełny tekst źródła
47
Léonard, Marie-Jeanne, Daniel Saumier i Alain Brunet. "When the Lawyer Becomes Traumatized: A Scoping Review". SAGE Open 10, nr 3 (lipiec 2020): 215824402095703. http://dx.doi.org/10.1177/2158244020957032.
Pełny tekst źródłaStreszczenie:
Lawyers can be exposed to cases involving traumatic elements of crimes. Such exposure may result in symptoms of posttraumatic stress disorder (PTSD) and have adverse effects on the lawyers’ capacities to work. A scoping review was conducted to summarize original investigations of work-related PTSD among lawyers in terms of (a) trauma exposure conceptualization and operationalization, (b) symptom severity, (c) prevalence, and (d) risk factors. The scoping review also aimed to highlight potential directions for future studies and clinical implications. Literature searches were conducted in PsycINFO, Embase, Pubmed, MEDLINE, PILOTS, and Google Scholar. Of 341 initial publications, 9 were included. A majority conceptualized the impact of work-related trauma exposure as secondary traumatic stress and operationalized work-related trauma exposure as the number of cases or clients involving traumatic material. Levels of PTSD symptoms reported by lawyers were positively related to levels of work-related trauma exposure.
48
Erbeznik, Milutin, Herbert J. Strobel, Karl A. Dawson i Chris R. Jones. "The d-Xylose-Binding Protein, XylF, from Thermoanaerobacter ethanolicus 39E: Cloning, Molecular Analysis, and Expression of the Structural Gene". Journal of Bacteriology 180, nr 14 (15.07.1998): 3570–77. http://dx.doi.org/10.1128/jb.180.14.3570-3577.1998.
Pełny tekst źródłaStreszczenie:
ABSTRACT Immediately downstream from the Thermoanaerobacter ethanolicus xylAB operon, comprising genes that encoded-xylose isomerase and d-xylulose kinase, lies a 1,101-bp open reading frame that exhibits 61% amino acid sequence identity to the Escherichia coli d-xylose binding periplasmic receptor, XylF, a component of the high-affinity binding-protein-dependent d-xylose transport. The 25-residue N-terminal fragment of the deduced T. ethanolicus XylF has typical features of bacterial leader peptides. The C-terminal portion of this leader sequence matches the cleavage consensus for lipoproteins and is followed by a 22-residue putative linker sequence rich in serine, threonine, and asparagine. The putative mature 341-amino-acid-residue XylF (calculated molecular mass of 37,069 Da) appears to be a lipoprotein attached to the cell membrane via a lipid anchor covalently linked to the N-terminal cysteine, as demonstrated by metabolic labelling of the recombinant XylF with [14C]palmitate. The induced E. coli avidly bound d-[14C]xylose, yielding additional evidence that T. ethanolicus XylF is thed-xylose-binding protein. On the basis of sequence comparison of XylFs to other monosaccharide-binding proteins, we propose that the sequence signature of binding proteins specific for hexoses and pentoses be refined as (KDQ)(LIVFAG)3IX3(DN)(SGP)X3(GS)X(LIVA)2X2A. Transcription of the monocistronic 1.3-kb xylF mRNA is inducible by xylose and unaffected by glucose. Primer extension analysis indicated that xylF transcription initiates from two +1 sites, both situated within the xylAB operon. Unlike in similar transport systems in other bacteria, the genes specifying the membrane components (e.g., ATP-binding protein and permease) of the high-affinity d-xylose uptake system are not located in the vicinity of xylF in T. ethanolicus. This is the first report of a gene encoding a xylose-binding protein in a gram-positive or thermophilic bacterium.
49
Chiplonkar, Shashi, Neha Kajale, Nikhil Lohiya, Lavanya Parthasarhty, Vaman Khadilkar i Anuradha Khadilkar. "Dietary Patterns in Underprivileged Indian Children and Adolescents with Type 1 Diabetes". Current Nutrition & Food Science 16, nr 6 (15.07.2020): 945–52. http://dx.doi.org/10.2174/1573401315666191126091201.
Pełny tekst źródłaStreszczenie:
Background: Children with diabetes are likely to have different food and nutrient composition due to dietary restrictions. Studies on dietary intakes in Indian underprivileged children with Type1 diabetes are scarce. Objective: To study dietary patterns and nutrient intakes of underprivileged children and adolescents with type1 diabetes in comparison with their healthy siblings. Methods: Cross-sectional study, diet assessed by 24-h recall on 3-non-consecutive days in 120 children with type1 diabetes (11.2 ± 3.8 yrs) and 65-age-gender matched healthy siblings. Dietary patterns determined by cluster analysis. Nutrient composition was compared by one-way ANOVA. Results: Children with diabetes belonged to middle/lower economic class. Mean HbA1C of children with diabetes was 9.7 ± 2.0% with higher intakes of whole cereals, milk, fruits, vegetables and lower intakes of refined cereals, pulses, animal products than healthy siblings (P <0.05). Four diet patterns were characterized on the basis of major foods: i) wheat, ii) millets, iii) rice and pulse and iv) milk and fruits. Though patterns were similar in both groups, significantly higher intakes of vitamin C (35 ± 23 vs. 24.7 ± 16.3 mg/d), zinc (5.6 ± 2 vs. 4.5 ± 2.3 mg/d), thiamin (812 ± 383 vs. 570 ± 254 μg/d), riboflavin (782 ± 341 vs. 352 ± 182 μg/d) and calcium (673 ± 272 vs. 461 ± 253 mg/d) noted in children with diabetes. Total energy, protein and carbohydrate intakes were comparable; fat consumption was significantly lower amongst children with diabetes, though above recommended daily allowance (RDA) 41.6 ± 14.1 gm vs. 47.4 ± 18.9 gm, P=0.029. Conclusion: Underprivileged children with diabetes and siblings had similar dietary patterns; children with diabetes consumed healthier diet than siblings, still glycemic control was not optimum. Dietary interventions are needed to improve micronutrient intake and reduce fat intake in underprivileged children with type1 diabetes to improve their glycemic control.
50
Dodson, W. Edwin, Marc Kamin, Lesley Kraut, William H. Olson i Shu-Chen Wu. "Topiramate Titration to Response: Analysis of Individualized Therapy Study (TRAITS)". Annals of Pharmacotherapy 37, nr 5 (maj 2003): 615–20. http://dx.doi.org/10.1345/aph.1c133.
Pełny tekst źródłaStreszczenie:
OBJECTIVE: To evaluate the relationship between baseline seizure frequency and stabilized topiramate dosage and the effect of individualized treatment on tolerability in adults with partial-onset seizures receiving other antiepileptic drugs (AEDs). METHODS: In this 20-week, open-label trial, dosages of medications were adjusted according to clinical response. Dosage and seizure response data were analyzed for 2 groups defined by baseline seizure frequency: <4 and ≥4 seizures per month. RESULTS: In the outcome evaluable population (n = 471), the mean ± SEM stable topiramate dosage was 303 ± 139 mg/d when baseline seizure frequency was <4 seizures/month and 341 ± 153 mg/d when baseline seizure frequency was ≥4 seizures/month (p = 0.005). The most common adverse events were somnolence (8.5%), fatigue (7.3%), nausea (5.3%), and dizziness (5.0%). Cognitive complaints were reported by <3% of patients. When concomitant AED dosages were reduced, 14% of patients discontinued topiramate due to adverse events compared with 23% if the concomitant AED dosage was unchanged or increased. CONCLUSIONS: When clinicians individualize topiramate dosage according to clinical response, the stabilized topiramate dosage as add-on therapy is influenced by baseline seizure frequency. Topiramate tolerability is improved when dosages of concomitant AEDs are reduced.