Rozprawy doktorskie: „D-256”

1

Abu, Alabbas Belal. "Between scripture and human reason : an intellectual biography of Muḥammad ibn Ismā'īl al-Bukhārī (d.256/870)". Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:e4ee70d8-9b60-4982-b382-4a96cd6f0553.

Pełny tekst źródła

Streszczenie:

By the dawn of the fifth/eleventh century, al-Bukhārī (d. 256/870) was recognized as the most highly regarded hadith scholar and his Ṣaḥīḥ as the most authoritative book, after the Qur'an. This canonical status promoted a romanticized version of al-Bukhārī that does not reflect the reality that his pre-canonical historical record presents. This study recovers the reality of al-Bukhārī and provides a critical biography of him, tracing the progress of his career and detailing the objectives of his work. It provides a re-assessment of al-Bukhārī's own juridical, theological, and hadith-criticism principles based on an analysis of his own works, arguing that al-Bukhārī was shaped by the split between hadith and ra'y. It distinguishes three stages in his career: early education under ra'y authorities, conversion to hadith-based school, and his critique of the ra'y-based scholars in Transoxania. Al-Bukhārī was a significant contender of theology and law in his own day and certainly promoted a moderate position in theology and law that proved crucial to his future renown. He appears to have been Medinese in law and Iraqi in hadith criticism. His legal theory adopts some of Mālik ibn Anas' (d. 179/795) views and al-Shāfi'ī's (d. 204/820) hermeneutical concepts. His legal method and positive law appear to be systematically anti-ra'y and exhibit a virulent disparage of Abū Ḥanīfa (d. 150/767) and al-Shaybānī (d. 192/804-5). It appears that al-Bukhārī composed the Ṣaḥīḥ over a long period, at least a decade, as the Ṣaḥīḥ itself tends to confirm a chronological progress. This progress, the author contends, was the outcome of al-Bukhārī's long project in Transoxania, combating ra'y and promoting hadith. Al-Bukhārī achieved prominence within hadith-based circles for his unique transmitter-criticism (rijāl) works, particularly al-Tārīkh, but when he conceded that one's utterance (lafẓ) of the Qur'an is created, he was immediately denounced by the hadith-based school. This controversy caused the collapse of al-Bukhārī's career, leading to his demise in Khartank near Samarqand in 256/870.

Style APA, Harvard, Vancouver, ISO itp.

2

Barouni, Ahmad Yousef. "A critical study and edition of the manuscript of al-Du'afa' (weak narrators) of Muḥammad ibn Ismāʻīl Bukhārī (d. 256 AH/869 CE)". Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25227.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

3

Barouni, Ahmad Yousef. "A critical study and edition of the manuscript of al-Du’afa’ (weak narrators) of Muḥammad ibn Ismāʻīl Bukhārī (d. 256 AH/869 CE)". Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=25227.

Pełny tekst źródła

Streszczenie:

This thesis is primarily concerned with a study and critical examination of the manuscript al-Du’afa’ of al-Bukhārī, which is one of the earliest and most important manuscripts to be written on the subject of Al-Jarh wa al-Ta'dil (disparagement and validity). This thesis is one of the first to examine existing manuscripts of this work, and in it five copies of the same manuscripts are compared. It is one of very few studies in the English language that critically examine the books of Al-Jarh wa al-Ta'dil to try to understand the methodology of its scholars, and to attempt a reconciliation between their differing opinions. At the same time, it will enrich the current Arabic literature in this field, as there has not yet been a complete study of this crucial manuscript in the field of Hadīth. This thesis may be considered to be an exposition of two main points: firstly, it collates and critically examines the terms of disparagement that have been used by al-Bukhārī or transmitted by him from his teachers in the manuscript al-Du’afa’, and a comparison of his usage of these terms with other common opinions regarding them. Also a comparison is made between al-Bukhārī's usage of these terms in this manuscript with his usage in his other books. Secondly, it involves a presentation of the manuscript al-Du’afa’ in a clear academic fashion that makes it accessible to students and researchers of all backgrounds. This study makes it apparent the great importance of the manuscript al-Du’afa’ in the field of Al-Jarh wa al-Ta'dil.

Style APA, Harvard, Vancouver, ISO itp.

4

Balagura, V., I. Adachi, H. Aihara, K. Arinstein, V. Aulchenko, T. Aushev, A. M. Bakich i in. "Observation of D_s1(2536)^+ → D^+π^-K^+ and angular decomposition of D_s1(2536)^+ →D^*+K_S^0". American Physical Society, 2008. http://hdl.handle.net/2237/11346.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

5

Pinheiro, Tânia Marisa Macedo. "A importância clínica da vitamina D". Master's thesis, [s.n.], 2015. http://hdl.handle.net/10284/5301.

Pełny tekst źródła

Streszczenie:

Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas
Nos últimos anos, o papel fisiológico da vitamina D tem sido amplamente estudado. A sua ação primordial no metabolismo do cálcio é já bem conhecida, sendo esta uma das hormonas responsáveis pela manutenção dos níveis de cálcio sérico, através da promoção da absorção de cálcio e fósforo a partir do intestino e da reabsorção óssea de cálcio. No entanto, o interesse clínico na vitamina D não se restringe apenas ao metabolismo fosfocálcio, mas também se manifesta em várias outras condições médicas (diabetes, doenças cardiovasculares, esclerose múltipla, câncer, distúrbios psiquiátricos, doenças neuro-muscular). De facto, evidências recentes correlacionam níveis insuficientes de vitamina D, com um risco aumentado de desenvolvimento de outras doenças, não relacionadas com a componente óssea. A elevada prevalência de níveis inadequados de vitamina D é hoje em dia encarada como um problema de saúde pública que afeta vários países da Europa e os EUA. Por este motivo, e pelo conhecimento do crescente número de doenças associadas a esta deficiência, a medição exata dos níveis de vitamina D tem assumido elevada relevância na clínica. Desta forma, o número de análises para avaliação da quantidade de vitamina D para fins de diagnóstico aumentou significativamente. A concentração de 25- hidroxivitamina D (25(OH)D) é o parâmetro de rotina, mas a determinação de outros metabolitos, em particular a forma fisiologicamente ativa 1,25 dihidroxivitamina D (1,25(OH)2D) pode ser também de interesse clínico. No entanto, os níveis séricos de 25(OH)D são o melhor indicador do conteúdo corporal de vitamina D, uma vez que reflete a quantidade obtida a partir da ingestão e exposição à luz solar, assim como da conversão de vitamina D a partir de depósitos de gordura no fígado. As últimas orientações da Endocrine Society sugerem o rastreio do défice de vitamina D apenas em indivíduos em risco e não na população em geral. Nestes doentes, recomenda-se a medição da 25(OH)D sérica circulante, por um método analítico fiável. Ao longo dos anos, técnicas de quantificação de 25(OH)D e a 1,25(OH)D têm aumentado e evoluído. Estes métodos são baseados em ensaios de ligação competitiva por meio de imunoensaio e cromatografia líquida associados com espectrometria de massa, no entanto estes têm demonstrado vários desafios analíticos, sendo que as vantagens e desvantagens de cada método mudam constantemente com novos desenvolvimentos tecnológicos. Os imunoensaios continuam a ser o modo predominante de medição para 25(OH)D, embora os problemas com a recuperação equimolar dos metabolitos D2 e D3 permanecem um problema. O défice de vitamina D é definido por um valor de 25(OH)D inferior a 20 ng/mL (50 nmol/L). Em indivíduos em risco recomenda-se a ingestão de vitamina D na dieta, de acordo com a idade e situações especiais (gravidez, amamentação, obesidade e toma concomitante de alguns fármacos). Para o tratamento e prevenção do défice de vitamina D sugere-se a utilização de qualquer das isoformas de vitamina D (o colecalciferol ou vitamina D3 e o ergocalciferol ou vitamina D2, em dose dependente do grupo etário e das necessidades específicas.
In recent years, the physiological role of vitamin D have been widely studied intensively. Its primary action on the calcium metabolism is well known, this being one of hormones responsible for the maintenance of serum levels of calcium, by promoting calcium and phosphorus absorption from the intestine and from bone calcium resorption. However, clinical interest in vitamin D is not restricted to the fosfocalcium metabolism but also is affects several other medical conditions (diabetes, cardiovascular disease, multiple sclerosis, cancer, psychiatric disorders, neuro-muscular disease). In fact, recent evidences correlates insufficient levels of vitamin D with an increased risk of developing other diseases, not related to bone component. The high prevalence of inadequate vitamin D levels is nowadays seen as a public health problem that affects several countries in Europe and the USA. For this reason, and the knowledge of the growing number of diseases associated with this deficiency, the exact measurement of vitamin D levels has assumed great relevance in the clinic practice. Thus, the number of assays to determine circulating vitamin D for diagnostic purposes has increased significantly. Circulating 25 hydroxyvitamin D (25 (OH)D) concentration is routinely used, but measurement of other metabolites, especially the physiologically active 1,25 dihydroxyvitamin D (1,25 (OH)2D), are of clinical value. However, serum levels of 25(OH)D are the best indicator of vitamin D body content, as it reflects the vitamin obtained from dietary intake and exposure to sunlight, as well as the conversion of vitamin D from fatty deposits in liver. The latest Endocrine Society guidelines suggest screening for vitamin D deficiency only in individuals at risk and not in the general population. In these patients, it is recommended the measurement of 25(OH)D circulating in serum, by a reliable analytical method. Over the years, the development of the methods to quantify 25(OH)D and 1,25 (OH)2D have increased and evolved. These method are based in competitive binding assays through to immunoassay and liquid chromatography aligned to mass spectrometry, however these have demonstrated various analytical challenges, the advantages and disadvantages of each method are constantly changing with new technological developments. Immunoassay remains the predominant mode of measurement for 25(OH)D although problems with equimolar recovery of the D2 and D3 metabolites remain an issue. The vitamin D deficiency is defined by a value of 25 (OH) D lower than 20 ng/mL (50 nmol/L). In individuals at risk, the intake of dietary vitamin D according to the age and special medical conditions is recommended (pregnancy, breastfeeding, obesity and concomitant intake of drugs). For treatment and prevention of vitamin D deficiency it is suggested the use of any of the isoforms (cholecalciferol or vitamin D3 and ergocalciferol or vitamin D2) in an age-dependent and individual dose.

Style APA, Harvard, Vancouver, ISO itp.

6

Rondeau, Marc. "Dosage sanguin de la 25 hydroxyvitamine d chez 128 entrants d'un service de medecine generale et rhumatologie a nantes". Nantes, 1988. http://www.theses.fr/1988NANT002M.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

7

Börjesson, Emma. "Analys av 25-hydroxyvitamin D i primärvården". Thesis, Linköpings universitet, Institutionen för medicin och hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-120406.

Pełny tekst źródła

Streszczenie:

Background: The interest of vitamin D has increased in the last years. That is because there is so many possible positive effects of vitamin D and also because many individuals has vitamin D deficiency. Modern man spends much time indoors which leads to lower levels of vitamin D. People who have emigrated from a sunny climate to a Nordic climate often gets a deficiency due to a more pigmented skin which requires a larger amount of UVB to get an adequate synthesis of vitamin D. Aim: The aim with this study is to compare and evaluate how similar the instrument mini VIDAS measures 25(OH)D total against the current existing method cobas e 602. A discussion about if 25(OH)D total has a place in primary health care is included in the study. Method: The comparison was based on 39 samples. The samples was analyzed on cobas e 602 and mini VIDAS. A precision test was performed. External controls from DEQAS was also included in the study. The results have been presented with simple linear regression analysis, mean value, SD and CV. Results: The comparison between cobas e 602 and mini VIDAS gave a coefficient of determination of 81,34 %. mini VIDAS was closest to the external controls target values. Conclusion: There is no obvious conclusions about if mini VIDAS fulfills the requirement to be introduced to primary health care. The coefficient of determination of 81,34 % should be at least 95 %. However is mini VIDAS closer to the external controls target values then cobas e 602. There is factors that implies that 25(OH)D total has a place in primary health care with regards to demand, use and because many individuals has vitamin D deficiency. The instrument is also user-friendly to a primary health care laboratory.
Bakgrund: Intresset för vitamin D har ökat de senare åren. Det beror dels på att det finns många eventuella positiva effekter av vitamin D och dels på att många individer har brist på vitamin D. Nutidens människa spenderar mycket tid inomhus vilket leder till lägre nivåer av vitamin D. Personer som har utvandrat från ett soligt klimat till nordiskt klimat får ofta brist på grund av en mer pigmenterad hud som behöver större mängd UVB för att få en adekvat syntes av vitamin D. Syfte: Syftet med den här studien är att jämföra och utvärdera hur lika det patientnära instrumentet mini VIDAS mäter 25(OH)D total mot befintlig metod cobas e 602. Diskussion om analysen 25(OH)D total har en plats i primärvården ingår även i studien. Metod: Jämförelsen baserades på 39 st prover. Proven analyserades på cobas e 602 och mini VIDAS. Ett precisionsförsök gjordes. Externkontroller från DEQAS inkluderades även i studien. Resultaten har presenterats genom enkel linjär regressionsanalys, medelvärde, SD och CV. Resultat: Jämförelsen mellan cobas e 602 och mini VIDAS gav en förklaringsgrad på 81,43 %. mini VIDAS var närmst externkontrollernas målvärden. Slutsats: Det går inte att dra självklara slutsatser ifall mini VIDAS uppfyller kraven att införas i primärvården. Förklaringsgraden som är på 81,43 % bör vara minst 95 %. Däremot överensstämmer mini VIDAS med externkontrollerna bättre än cobas e 602. Det finns faktorer som tyder på att analysen 25(OH)D har en plats i primärvården med avseende på efterfrågan, användningsområde och antal individer med brist. Instrumentet är dessutom användarvänligt för ett primärvårdslaboratorium.

Style APA, Harvard, Vancouver, ISO itp.

8

Wyatt, Candy. "Serum 25-hydroxyvitamin D concentration in relation to melanoma progress". Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/62441/2/Candy_Wyatt_Thesis.pdf.

Pełny tekst źródła

Streszczenie:

Dr Wyatt’s study investigated the complex relationship between vitamin D and melanoma, specifically if vitamin D status is associated with more aggressive melanomas. Exposure to solar ultraviolet radiation is the principal risk factor for melanoma and also the main source of vitamin D. This research found that insufficient vitamin D at time of melanoma diagnosis is significantly associated with poorer prognosis (as defined by tumour thickness). These results will contribute to a more refined public health message concerning melanoma and vitamin D, particularly in Queensland, which has the highest global incidence of melanoma, but vitamin D deficiency is not uncommon.

Style APA, Harvard, Vancouver, ISO itp.

9

Eisele, Susanne [Verfasser]. "Bildgebung koronarer Plaques mittels 256-Zeilen Multidetektor Computertomographie: Untersucher-Varianz bei der Plaquevolumetrie unter Verwendung einer semiautomatischen Plaqueerkennungs-Software / Susanne Eisele". Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1030316376/34.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

10

Quitzke, Marcus [Verfasser], i Gunnar [Akademischer Betreuer] Lund. "Detektionsgenauigkeit von Koronarplaques und Reproduzierbarkeit von Koronarplaquequantifizierungen mittels 256-Zeilen-Computertomographie unter Verwendung einer automatischen Koronarplaqueanalysesoftware / Marcus Quitzke. Betreuer: Gunnar Lund". Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/1074642473/34.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

11

Patel, Shalini. "Demographic, Dietary, and Lifestyle Determinants of Vitamin D Status in the US Population: National Health and Nutrition Examination Survey, 2005-2006". Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/nutrition_theses/37.

Pełny tekst źródła

Streszczenie:

Background: Determinants of vitamin D status are of interest when studying the epidemiology of disease in population groups because vitamin D is now recognized to decrease the risk of diseases such as osteoporosis, cancer, and cardiovascular disease. Understanding modifiable determinants of vitamin D status are important for managing vitamin D deficiency at the individual level and for addressing this issue at population level. Objective: The objective of this study was to evaluate the associations between serum vitamin D status (deficiency and insufficiency) and distinct demographic, dietary, and lifestyle characteristics of adults in the United States using a large, nationally representative sample survey, the National Health and Nutrition Examination Survey (NHANES) 2005-2006. Methods: The study sample consisted of 2340 adults aged 20-59 who had serum 25(OH)D measured and who had completed various questionnaires concerning dietary intake of vitamin D and other lifestyle factors. Multivariate logistic regression was used to estimate the odds ratio (OR) of vitamin D deficiency, insufficiency, and sufficiency in adults based on distinct demographic, dietary, and lifestyle characteristics. Statistical significance was set at α < 0.05. Results: The prevalence of vitamin D deficiency was higher in obese adults than in underweight to normal weight adults (50.9% ± 4.57 vs. 29.3% ± 3.57), higher in adults who reported no sunburns than in adults who reported ≥ 3 sunburns (49.9% ± 3.82 vs. 18.0% ± 3.07), and higher in adults who use sun protective measures regularly than in adults who do not (48.4% ± 3.93 vs. 27.0% ± 3.75). The prevalence of vitamin D deficiency increased as dietary intake of vitamin D decreased. Non-Hispanic black adults were significantly more likely to be vitamin D deficient (OR = 45.27, 95% CI = 17.27-118.64) and insufficient (OR = 9.37, 95% CI = 3.43-25.61) than non-Hispanic white adults. Significant positive associations were found between vitamin D deficiency and several characteristics, namely obesity (OR = 7.43, 95% CI = 4.33-12.77), physical inactivity (OR = 1.63, 95% CI = 1.03-2.58) poor dietary vitamin D intake (OR = 2.34, 95% CI = 1.44-3.81), non-supplement use or supplement use with a low amount of vitamin D (OR = 1.75, 95% CI = 1.05-2.89), and activities that decrease exposure to sunlight (from OR = 2.97, 95% CI = 2.14-4.13 to OR = 5.30, 95% CI = 3.17-8.85). Conclusion: The results of this nationally representative study demonstrate that obesity, physical inactivity, poor dietary intake of vitamin D, and low sunlight exposure increases the risk for vitamin D deficiency in U.S adults. Future studies are needed to investigate whether vitamin D supplementation, sunlight exposure, and vitamin D-fortified foods are efficient in correcting vitamin D deficiency and insufficiency among these groups.

Style APA, Harvard, Vancouver, ISO itp.

12

Ellfolk, Maria. "Regulation of Vitamin D 25-hydroxylases : Effects of Vitamin D Metabolites and Pharmaceutical Compounds on the Bioactivation of Vitamin D". Doctoral thesis, Uppsala universitet, Avdelningen för farmaceutisk biokemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9412.

Pełny tekst źródła

Streszczenie:

A 700bp portion of the promoter of CYP2D25, the porcine microsomal vitamin D 25-hydroxylase was isolated and sequenced. The computer analysis of the sequence revealed the existence of a putative VDRE at 220 bp upstream of the transcription start site. A CYP2D25 promoter-luciferase reporter plasmid was constructed in order to study the transcriptional regulation of the gene. Treatment with the vitamin D metabolites calcidiol and calcitriol suppressed the promoter, provided that the nuclear receptors VDR and RXR were overexpressed. Phenobarbital was also capable of suppressing the promoter if the nuclear receptors PXR or CAR were overexpressed. The 25-hydroxylases are not expressed solely in liver but in a wide array of other organs as well. It is therefore possible at least in theory to study the vitamin D 25-hydroxylation in human subjects using cells from extrahepatic organs, from which biopsy retrieval is easier than from the liver. Dermal fibroblasts are frequently used to study different pathological conditions in human subjects and they are easy to come by. Dermal fibroblasts were shown to express two vitamin D 25-hydroxylases: CYP27A1 and CYP2R1. The expression pattern of CYP2R1 displayed considerable interindividual variation. The fibroblasts were also capable of measurable vitamin D 25-hydroxylation, which makes dermal fibroblasts a possible tool in studying vitamin D 25-hydroxylation in human subjects. Little is known about the regulation of expression and activity of the human vitamin D 25-hydroxylases. Therefore dermal fibroblasts – expressing CYP2R1 and CYP27A1 – and human prostate cancer LNCaP cells, that express CYP2R1 and CYP2J2, were treated with calcitriol and phenobarbital and efavirenz, two drugs that give rise to vitamin D deficiency. Treatment decreased the mRNA levels of CYP2R1 and CYP2J2 provided that the treated cells also expressed the necessary nuclear receptors. CYP27A1 did not respond to any of the treatments. The treatments also managed to decrease the 25-hydroxylating activity of the cells. The results show that vitamin D 25-hydroxylases can be regulated by both endogenous and xenobiotic compounds.

Style APA, Harvard, Vancouver, ISO itp.

13

Peiris, Alan N., Beth A. Bailey, Todd Manning i Les N. Peiris. "Are 25-Hydroxyvitamin D Levels Adequately Monitors Following Evidence of Vitamin D Insufficiency in Veterans?" Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/6308.

Pełny tekst źródła

Streszczenie:

Vitamin D insufficiency remains a costly pandemic in veterans. Treatment requires achievement of desired 25-hydroxyvitamin D [25(OH)D] concentrations. The frequency with which 25(OH)D should be measured following treatment remains speculative. A retrospective analysis of veterans with vitamin D insufficiency was conducted. The group was stratified on the basis of initial 25(OH)D and assessed for frequency of follow-up 25(OH)D concentrations. Over 3 years, 278 patients with insufficient 25(OH)D concentrations were identified. Of these, 87 (31%) patients had subsequent levels assessed in the year following initial documentation of vitamin D insufficiency. The likelihood of follow-up testing was unrelated to the initial vitamin D level. In the patients with follow-up 25(OH)D levels, 90% eventually achieved a serum level of 30 ng/mL or greater. Veterans with vitamin D insufficiency have inadequate serial monitoring of 25(OH)D concentrations.

Style APA, Harvard, Vancouver, ISO itp.

14

Asano, Lisa. "Vitamin D metabolite, 25-Hydroxyvitamin D, regulates lipid metabolism by inducing degradation of SREBP/SCAP". 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225512.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

15

Rose, Stanley David. "Regulation of pituitary function by 1α,25-dihydroxyvitamin D₃". Thesis, Massachusetts Institute of Technology, 1985. http://hdl.handle.net/1721.1/95537.

Pełny tekst źródła

Streszczenie:

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Applied Biological Sciences, 1985.
MICROFICHE COPY AVAILABLE IN ARCHIVES AND SCIENCE.
Vita.
Includes bibliographical references.
by Stanley David Rose.
Ph.D.

Style APA, Harvard, Vancouver, ISO itp.

16

Bennett, Sarah. "3-epi-25 hydroxyvitamin D : assay development and measurement". Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.695221.

Pełny tekst źródła

Streszczenie:

Vitamin D is a prohormone produced in the skin following ultraviolet B (UVB) radiation exposure. It can also be obtained from natural sources such as oily fish, as well as from fortified foods or supplements. The main physiological role of vitamin 0 is in the maintenance of skeletal health. However, there is also emerging evidence that vitamin 0 may also be associated with several non-skeletal health outcomes including; type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD) and decreased pregnancy complications. Suboptimal vitamin 0 status is a common global issue. The accurate measurement of 250HD is hindered by epimers. Epimers are isomers which only differ in the configuration at one carbon atom. Subsequently, they have the same molecular weight, and can overlap chromatographically with vitamin 0 metabolites or internal standard peaks and give false estimates of true 250HD levels. In the present study, an ultra-performance liquid chromatography tandem mass spectrometry (UPLC/MS-MS) assay was developed, which was capable of assessing 250HD and 3-epi-250HD concentrations in human serum/plasma. The UPLC/MS-MS assay was used to measure 250HD and 3-epi-250HD levels in two cohorts; the first cohort consisted of pregnant women with type one diabetes and pregnant controls, while the other was a nested case-control cohort from the Prospective Epidemiological Study of Myocardial Infarction (PRIME) study, which consisted of men who had suffered a CVD event and controls. These results were then used to determine potential relationships between 250HD and 3-epi-250HD concentrations and; gestational and pregnancy outcomes, BMI, cardiovascular disease risk, as well as seasonal effects.

Style APA, Harvard, Vancouver, ISO itp.

17

Khan, Shanchita R. "Effect of sunlight exposure on 25-Hydroxyvitamin D concentration". Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/115121/2/Shanchita%20Khan%20Thesis.pdf.

Pełny tekst źródła

Streszczenie:

Sunlight generates vitamin D, but there is scant human data from randomised trials on which to base health policy advice about how much sun exposure is necessary to change 25(OH)D concentrations. This thesis studies the effect of solar ultraviolet (UV) radiation exposure on 25(OH)D concentration in a randomised controlled trial. The intervention group received nine standard erythemal dose of UV radiation over three weeks which caused a 2.5 nmol/L higher increase than that in the control group, although this was not statistically significant. This study identifies key issues to be considered in the design of a larger trial.

Style APA, Harvard, Vancouver, ISO itp.

18

Souza, Emily Fonseca de. "A unificação da Síria e o jihād de Nūr ad-Dīn na crônica Kitāb al-Kāmil fi l-ta\'rīkh, de Ibn al-Athīr". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/8/8138/tde-25102016-115357/.

Pełny tekst źródła

Streszczenie:

Em nossa dissertação, estudamos o excerto da crônica Kitāb al-Kāmil fi l-ta\'rīkh, de Ibn al-Athīr, que relata os anos de governo de Nūr ad-Dīn. Nossa pesquisa é dividida em três partes. Na primeira, apresentamos o autor e sua obra, a origem e a composição da crônica, além do debate historiográfico sobre a obra. Na segunda, abordamos os gêneros retóricos da Retórica de Aristóteles e a aplicação de dois destes gêneros, epidítico e deliberativo, na composição do discurso de Ibn al-Athīr. Na terceira, realizamos uma síntese das definições de jihād tanto no Alcorão quanto nos tratados jurídicos muçulmanos e mostramos como o nosso autor se apropria deles para legitimar as ações de Nūr ad-Dīn e construir, por meio de seu discurso, a figura do biografado como um exemplo de governante.
In our dissertation, we study the extract of Ibn al-Athīr\'s chronicle, Kitāb al-Kāmil fi l-ta\'rīkh, reporting the years of Nūr ad-Dīn\'s governmet. Our research is divided into three parts. The first presents the author and his work, the chronicles origin and the composition, besides presenting the historiographical debate on the work. The second approachs the rhetoric genres of Aristotles Rhetoric and the use of two of these genres, epideictic and deliberative, at the construction of Ibn al-Athīr\'s discourse. The third discusses the definitions of jihād both at Coran and at muslims juridical treatises, indicating how our author uses them to legitimate Nūr ad-Dīn\'s action in order to elaborate him, through his discourse, as an example of ruler.

Style APA, Harvard, Vancouver, ISO itp.

19

Bandzaitė, Virginija. "Vitamino D, kalcitonino ir parathormono kiekių kaita karvių kraujo serume bei reikšmė mineralinių medžiagų apykaitos procesams". Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20051230_125132-51108.

Pełny tekst źródła

Streszczenie:

Change particularities of the blood serum levels of vitamin D, calcitonin and parathyroid hormone were analysed in healthy cows of different feeding, age and productivity and in sick cows with metabolic diseases. It was investigated how biochemical indicators vary in cows with metabolic diseases (parturient paresis, osteomalacia and mastitis) and the most informative indicators for diagnostics of these diseases (for levels of calcium, phosphorus and magnesium) were determined. Obtained findings were processed statistically. The method of electrochemiluminescence analysis used for analysis of the blood serum levels of PTH in humans was applied. Compared with radioimmunic method, this method is not expensive and quite fast; in addition, this method is sensitive and reliable, because it permits to detect low levels of PTH in the blood serum (up to 0.127 pmol/l). The method of chemiluminescence immunometric analysis used to find the level of CT in humans was tested. Also the method of immunoferment analysis (ELISA) was tested to measure the blood serum level of 25-OH vitamin D in cattle using human antibodies.

Style APA, Harvard, Vancouver, ISO itp.

20

Morris, Carolyn W. "The Relationship Between Serum 25-Hydroxyvitamin D, Vitamin D and Calcium Intake, and Adiposity in Infants". Digital Archive @ GSU, 2013. http://digitalarchive.gsu.edu/nutrition_theses/46.

Pełny tekst źródła

Streszczenie:

Purpose: National prevalence of childhood overweight and obesity has plateaued in recent years, but rates remain high, with approximately 10% among children“high weight.” The relationship between adiposity and serum 25-hydroxyvitamin D [25(OH)D] status has been well-explored in older individuals, with inconsistent results. Furthermore, previous studies have suggested a relationship between adequate consumption of calcium and vitamin D and healthy weight status in older children and adults. However, in the infant population, there are few studies detailing the interaction between body composition and serum 25(OH)D or intake of calcium and vitamin D. Our study aims were to assess the association between serum 25(OH)D and body composition and to examine the association between adiposity and dietary intake of calcium and vitamin D in a sample of infants and toddlers. Methods: Our population included healthy male and female infants and toddlers from Pittsburgh, PA who participated in the “Practices Affecting Vitamin D Status in Pittsburgh Infants and Toddlers” study. Parents completed a Vitamin D and Sunlight Exposure Questionnaire, which assessed dietary intake of foods high in calcium and vitamin D as well as daily sunlight exposure (≥2 hours vs. >2 hours). Anthropometric measures and bloodwork for serum 25(OH)D were obtained during at the time of the study visit. Weight-for-length (WFL) percentile status was determined using WHO growth standards (low weight97.7 %ile) and WFL z-scores were calculated. ANOVA was used to compare mean serum 25(OH)D and calcium and vitamin D intake by WFL status. Chi square analysis was used to evaluate the relationship between serum 25(OH) D status (deficient =/mL, insufficient = 12-20 ng/mL, sufficient >20 ng/mL), calcium intake status (sufficient = >700 mg), vitamin D intake status (sufficient = >400 IU) and WFL percentile status. Pearson’s correlation coefficient was used to assess the strength and significance of associations between serum 25(OH)D, calcium and vitamin D intake and WFL z-score. The analysis was repeated after subdivision by race and sun exposure. Results: 125 infants and toddlers (9 to 24 months of age, 68% African American) participated in the study. Approximately 11% of the population had a high weight. Mean vitamin D intake (~600 IU/d) and median calcium intake (~1550 mg/d) exceeded recommendations. Prevalence of high weight was higher among children with adequate intake compared to those who consumed less than the recommendations (calcium: 41% vs. 36%, respectively; vitamin D: 45% vs. 29%, respectively). However, this difference was not statistically significant. Mean serum 25(OH)D level (37 ng/mL) was sufficient. When compared across WFL status, neither mean serum 25(OH)D nor mean intake of calcium and vitamin D varied significantly. No significant correlation was found between WFL and serum 25(OH)D for the cohort or any of the subgroups examined. Conclusions: Rates of infant overweight and obesity in our sample are similar in comparison with the national average. Our results do not support a relationship between calcium and vitamin D intake on weight status or an association between serum vitamin D and body composition in children of this age. Future studies are needed to re-examine these relationships in a larger group of children of more evenly distributed weight status.

Style APA, Harvard, Vancouver, ISO itp.

21

Martineau, Bernadette. "Associations of Serum Vitamin D Concentrations with Dietary Patterns in US Children". Digital Archive @ GSU, 2012. http://digitalarchive.gsu.edu/nutrition_theses/33.

Pełny tekst źródła

Streszczenie:

Background: Contribution of dietary sources to vitamin D status is not clearly known. Some studies have shown that dietary intake of certain vitamin D rich foods had a significant positive influence on serum 25-hydroxyvitamin D [25(OH)D] concentrations, whereas other studies have shown no effect. Although sunlight exposure is a major source of circulating serum 25(OH)D, children and adolescents have been advised on the dangers of sun exposure. Diet may therefore be an important contributor of circulating serum 25(OH)D in absence of or reduced sunlight exposure. Objective: The aim of this study was to determine whether serum 25(OH)D concentrations were associated with any specific dietary patterns in US children and adolescents using assay-adjusted serum 25(OH)D data from National Health and Nutrition Examination Survey (NHANES) 2003-2004 and 2005-2006. Methods: Data from 2 cycles of the NHANES 2003-2004 and 2005-2006 for individuals aged 2 to ≤19 y, were used to study the association between dietary patterns and serum 25(OH)D. Dietary patterns were established using factor analysis based on food-frequency questionnaire data. Eigenvalues and Scree plot were used to derive 2 major principal factors. They were labeled as High Fat Low Vegetable (HFLV) and Prudent dietary patterns. Results: Serum 25(OH)D was significantly lower in HFLV dietary pattern group compared to Prudent dietary pattern group (25.1 vs 27.0 ng/mL; P=0.001). The highest serum 25(OH)D concentrations for all subjects were in the low-intake HFLV group or medium and high-intake Prudent groups (P=0.003 and P=0.012, respectively). In multivariate adjusted analysis, children with higher Prudent dietary contribution scores to overall diet showed a significant positive relation with serum 25(OH)D (β=62.01, P=0.016). When data were stratified by sex, a significant positive relation was observed in girls who consumed the Prudent diet (β=86.34, P=0.014) and a significant negative relation was observed in girls who consumed the HFLV diet (β=-84.32, P=0.022). Conclusion: Overall, serum 25(OH)D concentrations were associated with Prudent dietary pattern but not with HFLV dietary pattern in US children and adolescents. When stratified by sex, the relation between dietary patterns and serum 25(OH)D was confined to only girls. Children consuming HFLV pattern diet may benefit from vitamin D supplementation and sunlight exposure (outdoor activities), and should be encouraged to consume more vitamin D fortified foods.

Style APA, Harvard, Vancouver, ISO itp.

22

Yener, Mahmut Akkaş Selami. "Fibromyalji'li hastalarda serum 25-hidroksi D vitamini ve parathormon düzeyleri /". Isparta : SDÜ Tıp Fakültesi, 2005. http://tez.sdu.edu.tr/Tezler/TT00216.pdf.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

23

Milone, Cristiana. "Association between Serum Vitamin D Concentrations and Depression in the US Population: National Health and Nutrition Examination Survey, 1988-1994". Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/nutrition_theses/5.

Pełny tekst źródła

Streszczenie:

Background: The role of nutrients in mental health has recently been recognized and investigated. Vitamin D has been known to play a role in a wide range of diseases, such as bone, cardiovascular, and autoimmune diseases, and cancers. Recently, its role in cognitive function and mental health has been reported. Vitamin D receptor and hydroxylases have been mapped throughout the brain, suggesting a role for vitamin D in brain tissue. An inverse association between vitamin D and depression was observed in European epidemiologic studies. There is a paucity of data on the association between vitamin D concentrations and depression in the U.S. population. Objective: The objective of this study was to investigate the association between serum vitamin D concentrations and depression in a large, nationally representative sample survey, the third National Health and Nutrition Examination Survey 1988-1994 (NHANES III). Methods: The study sample included 7970 adults, ages 15-39 years, who completed the Diagnostic Interview Schedule for depression and had vitamin D concentrations measured. SAS and SUDAAN statistical software packages were used in data analysis. Multivariate logistic regression was used to estimate the likelihood of having depression in vitamin D deficient persons in relation to vitamin D sufficient persons, after taking several confounding variables into consideration. Significance was set at α < 0.05. Results: The prevalence of vitamin D deficiency was higher in women than in men (24 % vs. 15%), higher in African-Americans than in whites (60% vs. 10%), higher in people living in metropolitan rather than in rural areas (25% vs. 14%), and higher in subjects below the poverty threshold than in higher income subjects (29% vs. 14%). The prevalence of vitamin D deficiency increased as BMI increased. The diagnostic variables for depression did not show an association with vitamin D deficiency after adjusting for several confounding factors. However, subjects having a depressive episode at the time of the interview, were significantly more likely to exhibit vitamin D deficiencies (OR = 1.85; P = 0.0210). Conclusions: This is the first large epidemiologic study on the association between vitamin D and depression in a US representative sample survey. A significant positive association was found between subjects having an episode of depression and vitamin D deficiency. However, a causal relationship could not be established due to the cross-sectional nature of the study. Further studies need to investigate the mechanistic and causal relation between vitamin D and depression.

Style APA, Harvard, Vancouver, ISO itp.

24

Tommie, Jessica. "Serum Vitamin D Status and Breast Cancer Risk by Receptor Status: A Systematic Review". University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin150480332518945.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

25

Huang, Alice. "Calcium-sensing Receptor Mediated Control of CYP27B1 Promoter-dependent Gene & Protein Expression: Complex Extracellular Ca2+ Concentration Dependence". Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20127.

Pełny tekst źródła

Streszczenie:

Changes in extracellular Ca2+ (Ca2+o) differentially modulate 25-hydroxyvitamin D3 1α-hydroxylase (1αOHase; encoded by CYP27B1) mRNA and protein levels in cell types including the renal proximal tubule (inhibitory), parathyroid, and skeletal osteoblasts (stimulatory) to control 1,25-dihydroxyvitamin D3 synthesis. We hypothesised that the calcium-sensing receptor (CaSR) mediated Ca2+o concentration-dependent control of 1αOHase, either directly through Ca2+o, or through the local production of parathyroid hormone related peptide (PTHrP). To investigate promoter activity, I transfected a firefly luciferase reporter gene under the control of the 1501 bp human CYP27B1 promoter into HEK-293 cells that stably expressed the CaSR (HEK-CaSR cells) and measured luciferase activities from cells exposed to various Ca2+o concentrations. CYP27B1 promoter-controlled luciferase expression exhibited a biphasic Ca2+o-dependent response in luciferase activity and protein that peaked with a 2-fold increase from basal levels at around 3.0 mM Ca2+o in HEK-CaSR cells. This response was absent in HEK-293 cells and was shifted to the left or right in the presence of the CaSR positive allosteric modulator, cinacalcet, or negative allosteric modulator, NPS-2143, respectively, indicating that both the stimulatory and inhibitory phases were CaSR-mediated. Firefly luciferase and 1αOHase mRNA levels obtained from quantitative RT-PCR exhibited a monophasic Ca2+o-dependent increase and suggests that the stimulatory phase arises from increased mRNA expression, whereas the inhibitory phase arises from reduced protein levels. Inhibitor and mutational studies suggested that the stimulatory phase was dependent on Gq/11 signalling, whereas the inhibitory phase requires MEK and PKC-dependent phosphorylation of the crucial T888 site of the CaSR's C-terminal tail.

Style APA, Harvard, Vancouver, ISO itp.

26

Bahner, Johannes [Verfasser]. "Quantifizierung der Aortenklappenöffnungsfläche in der 256-Zeilen Computertomographie: Ein Vergleich mit der transösophagealen Echokardiographie und dem Herzkatheter bei Patienten mit hochgradiger Aortenklappenstenose vor perkutanem Aortenklappenersatz / Johannes Bahner". Ulm : Universität Ulm. Medizinische Fakultät, 2012. http://d-nb.info/1028862334/34.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

27

Kohlhaus, Rebekka Katharina Verfasser], i Guido [Akademischer Betreuer] [Sauter. "Die Rolle von p53, Ki-67, HER2 und TRRAP beim duktalen Adenokarzinom des Pankreas: Eine Gewebe - Mikroarray - Untersuchung an 256 Tumoren / Rebekka Katharina Kohlhaus. Betreuer: Guido Sauter". Hamburg : Staats- und Universitätsbibliothek Hamburg, 2011. http://d-nb.info/102041832X/34.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

28

Palaniswamy, S. (Saranya). "Vitamin D status and its association with leukocyte telomere length, obesity and inflammation in young adults:a Northern Finland Birth Cohort 1966 study". Doctoral thesis, Oulun yliopisto, 2018. http://urn.fi/urn:isbn:9789526219295.

Pełny tekst źródła

Streszczenie:

Abstract Vitamin D deficiency, obesity and short telomere length are reported to be associated with increased risk of metabolic diseases and all-cause mortality, through modulation of inflammatory pathways. The season of blood sampling, obesity and physical activity have been identified as determinants of 25-hydroxyvitamin D [25(OH)D], but their association with 25(OH)D2 (D2) and 25(OH)D3 (D3) is still poorly understood. In addition, relationships between 25(OH)D, body mass index (BMI), inflammation, and leukocyte telomere length (LTL) has not been previously established. A better understanding of the determinants, risk factors of vitamin D deficiency, and their relationship with BMI, inflammation, and LTL is needed. The study was based on the 31-year follow-up study of the Northern Finland Birth Cohort 1966 (N=4,758). Statistical analyses were used to 1) examine potential determinants of D2 and D3, and identify risk factors associated with hypovitaminosis D, 2) investigate the relationship of 25(OH)D and BMI with LTL and test whether it is independent of inflammatory pathways and, 3) assess how the association of BMI with inflammatory biomarkers might be mediated through 25(OH)D. Our results showed that D2 contributed 5% and D3 95% of the total 25(OH)D concentrations. When examined, the determinants for each isoform, periods of low sunlight exposure associated with increased D2, but with decreased D3. Oral contraceptives associated with increased concentrations of both. We confirmed the known risk factors of low vitamin D: low sunlight periods, residing in northern latitudes, and physical inactivity. Serum 25(OH)D was not an important determinant of LTL, and inflammation may partly mediate the BMI-LTL association. Higher serum 25(OH)D was inversely associated with inflammatory biomarkers, and the association between BMI and biomarkers was modestly mediated through lowered 25(OH)D. In conclusion, our results support the role of known risk factors in vitamin D deficiency and add information on specific determinants of D2 and D3. 25(OH)D did not associate with LTL in young adulthood. We have also provided new insights into a plausible role of vitamin D in BMI associated inflammation. An improved understanding of the role of vitamin D benefits public health in many ways (it can help prevent vitamin D deficiency by implementing lifestyle modification and supplementation)
Tiivistelmä D-vitamiinin puutos, lihavuus ja lyhyt telomeerien pituus liittyvät mahdollisesti lisääntyneeseen riskiin sairastua metabolisiin sairauksiin sekä yleisemmin kuolleisuuteen. Eräs selitys tälle voi löytyä tulehdustekijöistä. Lihavuuden, liikunnan puutteen ja verinäytteenoton ajankohdan tiedetään vaikuttavan 25-hydroksi-D-vitamiinin [25(OH)D]-pitoisuuteen, mutta niiden yhteys D-vitamiinin isomuotoihin (D2, D3) on vielä huonosti tunnettu. Aiemmin ei ole selvitetty 25(OH)D:n, painoindeksin (BMI), tulehduksen ja leukosyyttien telomeerien pituuden (LTL) välisiä yhteyksiä, ja siksi näistä tarvitaan lisätutkimusta. Tutkimusaineistona oli Pohjois-Suomen 1966 syntymäkohortin, 31-vuoden seurantaan osallistuneet henkilöt (N=4,758). Tutkimuksessa keskityttiin 1) selvittämään D2- ja D3-vitamiinipitoisuuksien määrittäviä tekijöitä ja tunnistamaan D-vitamiinin puutteeseen liittyviä riskitekijöitä, 2) tutkimaan 25(OH)D-pitoisuuden ja BMI:n suhdetta LTL:n kanssa sekä testaamaan, onko suhde riippumaton tulehduksellisista tekijöistä ja 3) arvioimaan ilmeneekö BMI:n ja tulehdussytokiinien välinen yhteys 25(OH)D-pitoisuuden kautta. Tutkimus osoitti, että D2-isomuodon osuus oli 5 % ja D3:n osuus 95 % koko 25(OH)D-pitoisuudesta. Näitä isomuotoja määrittäviä tekijöitä tutkittaessa havaittiin, että vähäisellä auringonvalolle altistumisella on todennäköisesti yhteys lisääntyneeseen D2-pitoisuuteen, mutta alhaisempaan D3-pitoisuuteen. Suun kautta otettavien ehkäisypillereiden käytöllä oli yhteys molempien muotojen lisääntyneisiin pitoisuuksiin. Tutkimus vahvisti alhaisten D-vitamiinipitoisuuksien tunnetut riskitekijät: lyhyt altistus auringon valolle sekä fyysinen passiivisuus. 25(OH)D-pitoisuus ei ollut yhteydessä LTL:ään mutta tulehdus näytti osittain vaikuttavan BMI-LTL-assosiaatioon. Korkeampi 25(OH)D-pitoisuus yhdistyi matalampiin tulehdussytokiinipitoisuuksiin, kun taas matala 25(OH)D-pitoisuus muokkasi BMI:n ja biomarkkereiden välisisiä yhteyksiä, tosin heikosti. Yhteenvetona voidaan todeta, että tulokset tukevat tunnettujen riskitekijöiden merkitystä D-vitamiinin puutoksessa ja tuovat lisää tietoa eri isomuotoihin vaikuttavista tekijöistä. Tutkimus antaa myös uusia näkemyksiä D-vitamiinin roolista lihavuuteen liittyvässä matala-asteisessa tulehduksessa. D-vitamiinin vaikutuksien tarkempi tunteminen on merkityksellistä myös kansanterveyden kannalta

Style APA, Harvard, Vancouver, ISO itp.

29

Marcondes, Natália Aydos. "Avaliação dos níveis de 25-hidroxivitamina D e fatores associados em população não pediátrica portadora de fibrose cística". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2013. http://hdl.handle.net/10183/115588.

Pełny tekst źródła

Streszczenie:

Introdução: Portadores de fibrose cística têm uma susceptibilidade à deficiência de vitamina D devido à má absorção de nutrientes. Os estudos da prevalência de hipovitaminose D em pacientes com fibrose cística apresentam resultados extremamente variáveis e não há dados a respeito da população não pediátrica no Brasil. Objetivos: Avaliar a prevalência de hipovitaminose D em pacientes não pediátricos portadores de fibrose cística e os fatores associados com as concentrações séricas de 25-hidroxivitamina D. Metodologia: Realizado estudo transversal. A população em estudo foi composta por pacientes maiores que 16 anos acompanhados no Ambulatório de Fibrose Cística do Hospital de Clínicas de Porto Alegre. Foi avaliada a prevalência de deficiência de vitamina D, definida como 25-hidroxivitamina D < 30ng/mL, de acordo com a Cystic Fibrosis Foundation, bem como os fatores clínicos e laboratoriais associados com o valor sérico desta. Foram avaliados o estado nutricional e internações hospitalares. Foi realizada coleta de dados em prontuário, entrevista com os pacientes e colheita de sangue. As análises laboratoriais foram realizadas no Laboratório de Patologia Clínica do Hospital. Foram dosados os valores séricos de proteína C-reativa, cálcio, fosfato, magnésio, albumina, 25-hidroxivitamina D (método: quimiluminescência) e paratormônio (método: imunoensaio para PTH intacto). A função pulmonar foi avaliada por espirometria e escores clínicos e radiológicos. O nível de significância estatística foi estabelecido como P<0,05. Resultados: A prevalência de hipovitaminose D foi de 61,0%, com valores séricos de 25-hidroxivitamina D de 28,42±10,94 ng/mL. Os pacientes com insuficiência pancreática apresentaram uma tendência a ter concentrações mais altas de vitamina D. Dezesseis pacientes apresentavam doença pulmonar grave, com FEV1% do predito inferior a 40%. Após análise multivariada, índice de massa corporal e hospitalizações no último mês permaneceram significativamente associados negativamente aos valores séricos de 25-hidroxivitamina D. Conclusões: A prevalência de hipovitaminose D no presente estudo foi inferior a previamente relatada. A insuficiência de vitamina D continua sendo um problema nos pacientes com fibrose cística, mesmo naqueles recebendo suplementação.
Introduction: Cystic fibrosis patients have a susceptibility to vitamin D deficiency due to nutrient malabsorption. Prevalence studies of hypovitaminosis D in patients with cystic fibrosis have highly variable results and there is no data about the non pediatric population in Brazil. Objectives: To evaluate the prevalence of hypovitaminosis D in non pediactric cystic fibrosis patients and the factors associated with serum 25-hydroxyvitamin D levels. Methods: Cross-sectional study. The study population was composed of patients older than 16 years accompanied in the Cystic Fibrosis Ambulatory of the Hospital de Clínicas de Porto Alegre. We evaluated the prevalence of vitamin D deficiency defined as 25-hydroxyvitamin D < 30 ng/mL, as suggested recently by the Cystic Fibrosis Foundation, and clinical and laboratory factors associated with its serum levels. Nutritional status and hospital admissions were evaluated. Data was collected from medical records and interviews with patient, blood was collected. Laboratory analisys were performed at Clinical Pathology Laboratory of the Hospital. Serum C-reactive protein, calcium, phosphate, magnesium, albumin, 25-hydroxyvitamin D (method: chemiluminescence), and parathyroid hormone levels (method: sandwich immunoassay to intact PTH) were measured. Lung function was evaluated by spirometry and clinical and chest radiographic scores were assessed. Statistical significance level was set at P<0.05. Results: Prevalence of hypovitaminosis D was 61.0 %, with serum 25-hydroxyvitamin D levels of 28,42±10,94 ng/mL. Patients with pancreatic insufficiency had a trend to have higher vitamin D levels. Sixteen patients had severe lung disease with FEV1% predicted below 40%. After multivariable analysis, body mass index and hospitalization in the last month remained significantly associated negatively with serum 25-hydroxivitamin D levels. Conclusions: The prevalence of hypovitaminosis D in the present study was inferior to previously related. Vitamin D insufficiency is still a problem in cystic fibrosis patients, even in those receiving supplementation.

Style APA, Harvard, Vancouver, ISO itp.

30

Chen, Nancy Nannan. "The effect of vitamin D supplementation during pregnancy and lactation on maternal & infant 25-hydroxyvitamin D concentration". Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44967.

Pełny tekst źródła

Streszczenie:

BACKGROUND: Adequate vitamin D during pregnancy and lactation is important for optimal health of mother and infant. Due to low levels of vitamin D occurring in breast milk, exclusively breastfed infants are recommended by Health Canada to be supplemented with 400 IU/day of vitamin D. A potential solution to this is maternal vitamin D supplementation during pregnancy and lactation to raise maternal, infant serum 25-hydroxyvitamin D (25OHD) and breast milk vitamin D content. OBJECTIVE: To determine the effect of three dose regimens of supplemental vitamin D (400 IU/d, 1000 IU/d and 2000 IU/d) during pregnancy and lactation on maternal and infant 25-hydroxyvitamin D concentrations at 8 weeks post-partum. METHODS: In a double-blind, randomized controlled trial healthy pregnant women (n=226) between 13-24 weeks of gestation were recruited from Vancouver, Canada and randomized to take one of three doses of supplemental vitamin D3 (400 IU/d, 1000 IU/d or 2000 IU/d) until 8 weeks postpartum. Maternal blood was collected at baseline, 36 weeks gestation, and maternal and infant blood were collected 8 weeks postpartum. RESULTS: Mean 25OHD was 66 nmol/L at baseline and 21% of participants had a 25OHD < 50 nmol/L. At 8 weeks postpartum, maternal serum 25OHD concentrations [mean (95% CI)] were highest in the 2000 IU/d [87 (83, 90) nmol/L] followed by the 1000 IU/d [78 (74,81) nmol/L] and the 400 IU/d [69 (66, 73) nmol/L] group using intent to treat analysis. Likewise, at 8 weeks serum 25OHD concentrations were highest in infants whose mothers received 2000 IU/d [75 (67, 83 nmol/L)] followed by the 1000 IU/d [52 (45, 58) nmol/L] and the 400 IU/d [45 (38,52) nmol/L]. CONCLUSION: Maternal vitamin D supplementation of 2000 IU/d during pregnancy and lactation was found to be protective against vitamin D deficiency in infants for the first two months after birth. Generally, vitamin D supplementation increased maternal and infant 25OHD concentrations in a dose response manner.

Style APA, Harvard, Vancouver, ISO itp.

31

Beyer, Sarah. "Effekten av vitamin D2 vs. D3 på 25(OH)D-statusen : En litteraturstudie". Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-76417.

Pełny tekst źródła

Streszczenie:

Bakgrund: Vitamin D finns i två olika former, det animaliska D3 (kolekalciferol) och det vegetabiliska D2 (ergokalciferol). Det har rått olika åsikter bland läkarkåren och allmänheten om vilken av de två formerna som är mest potent för att höja 25(OH)D-statusen i blodet, det värde som mäts för att avgöra vitamin D-halten i kroppen. Då vitamin D-brist är vanligt förekommande bland befolkningen i Norden är det viktigt att veta vilken form som har bäst effekt och som därför bör användas för att behandla och förebygga vitamin D-brist. Det har även betydelse för veganer som inte äter det animaliska D3, där rekommendationen kanske behöver ändras. Syfte: Syftet med studien var att ta reda på om det finns någon skillnad i potensen av D2 respektive D3 för att höja 25(OH)D-statusen i blodet och i så fall, att hitta möjliga orsaker till denna skillnad. Metod: Sex relevanta vetenskapliga originalartiklar, som har undersökt effekten av D2 vs. D3 på 25(OH)D-statusen i blodet, hittades i databasen PubMed. Studierna genomfördes mellan 2008 och 2017. Studiedeltagarna var vuxna friska människor. Resultat: Fyra av studierna pekade på att D3 var mer effektivt än D2 för att höja 25(OH)D-statusen. En studie kom fram till att det inte fanns någon skillnad i potensen mellan D2 och D3 och en studie visade att D2 var mer effektivt jämfört med D3 när det gällde daglig behandling med låga doser men att D3 uppvisade bättre effekt vid behandling med höga doser med två eller fyra veckors avstånd. Slutsats: Majoriteten av studierna visade en bättre effekt av D3 än D2 för att höja 25(OH)D-nivåer i blodet. De blandade resultaten samt det begränsade antalet studier och deltagare gör att det inte är möjligt att kunna komma fram till en tydlig slutsats.
Background: Vitamin D comes in two different forms, D3 from animals (cholecalciferol) and D2 from plants (ergocalciferol). There has been different opinions among physicians and the general public about which of the calciferols is more potent to raise 25(OH)D-levels in the blood, which is the value that is measured to determine the vitamin D-status in the body. Since vitamin D deficiency is common among the people of the Nordic countries it is important to know which form has the best effect and should be used to treat and prevent vitamin D deficiency. Furthermore, it is relevant for vegans who do not eat the animalic D3, where recommendations might have to be changed. Aim: The aim of the study was to find out if there were differences in potency of D2 vs. D3 to raise 25(OH)D status in the blood and if so, to find possible explanations for those differences. Methods: Six relevant original articles that examined the effect of D2 vs. D3 on 25(OH)D status in the blood, were found in the database PubMed. The studies where published between the years 2008 and 2017. The participants were healthy adults. Results: Four of the studies suggested that D3 is more effective than D2 in order to raise the 25(OH)D status. One study concluded that there is no difference in the effectiveness of D2 vs D3 and one study showed that D2 is more effective than D3 when it comes to daily treatment but that D3 has a better effect than D2 when treatment happens on a two or four weekly basis with large doses. Conclusion: Most of the articles suggested a better effectiveness of D3 than D2 to raise 25(OH)D levels in the blood. However, besides the mixed results, the number of studies and participants was too small to come to a clear conclusion.

Style APA, Harvard, Vancouver, ISO itp.

32

Omoike, Gracious. "Har D-vitamintillskott effekt vid behandling av Systemisk Lupus Erythematosus? : En litteraturstudie". Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-85942.

Pełny tekst źródła

Streszczenie:

Introduktion: Systemisk Lupus Erythematosus är en prototypisk autoimmun sjukdom som gör att immunförsvarets antikroppar angriper kroppens egna vävnader, vilket leder till kronisk inflammation i kroppens organsystem. Idag finns ingen verksam behandling för Systemisk Lupus Erythematosus. Syftet med denna studie var att undersöka hur Dvitamintillskott påverkar Systemisk Lupus Erythematosus. Metod: Artiklarna hittades i databasen ”Pubmed” med sökningen ”Systemic Lupus Erythematosus and vitamin D supplementation”. Bland sökresultaten fanns sex relevanta artiklar som hade undersökt effekten av D-vitamintillskott på SLE. Resultat: Mer än hälften av patienterna i samtliga studier nådde serum 25(OH) D-nivåer som ansågs vara tillräckliga. D-vitamintillskottet minskade Th1/Th17-cellerna men ökade också Treg-celler och Th2-celler. Tre studier visade sig ha en signifikant minskning i sjukdomsaktivitet och anti-dsDNA antikroppar. Komplement C3 minskade i studie 2. Diskussion: Fem av studierna tyder på att oral administrering av D-vitamin tillskott har gett positiv inverkan på SLE. Två av de granskade studierna rapporterades inge positiv klinisk effekt hos deltagarna. Slutsats: D-vitamintillskott dämpar immunsystemet genom att öka Treg-celler och Th-2-celler men även minska Th1/Th17-celler och B-celler samt produktionen av autoantikroppar och anti-dsDNA-antikroppar. Effekten av D-vitamintillskott på komplement C3 och C4 är oklar. Det krävs dock fler studier med fler deltagarantal för att dra en slutsats om Dvitamintillskott kan användas som behandling för SLE.
Background: Systemic Lupus Erythematosus is a prototypical autoimmune disease in which antibodies attack healthy tissues in the body, causing inflammation in several organs. Aim: The aim of this literature study was to investigate the effect of Vitamin Dsupplementation on SLE. Method: The articles were searched in the database called ”Pubmed” using the search terms ”Systemic Lupus Erythematosus and Vitamin D supplementation”. Six of the articles which examined the effects of D-vitamin supplementation on SLE were relevant for this study. Result: More than half of the patients in all six studies reached sufficient serum 25(OH)D. Vitamin D-supplement reduced Th1/Th17-cells but increased Tregs-cells and Th2-cells. 3 studies showed a decrease in disease-activity and anti-dsDNA. C3 decreased in study 2. Discussion: Five studies indicated that the oral administration of vitamin-D supplementation had a positive effect on SLE. Two of the examined studies did not observe any clinical effect of the vitamin-D supplement. Conclusion: Vitamin-D supplement suppresses the immunesystem by increasing Treg cells and Th-2 cells but also reducing Th1/Th17-cells and B-cells as well as the production of autoantibodies and anti-dsDNA antibodies. The effect of vitamin D-supplement is unclear. More studies with more participants are required to determine if vitamin-D supplement can be used as a treatment for SLE.

Style APA, Harvard, Vancouver, ISO itp.

33

Velarde, Laos Edmundo. "Fatty acid and lipid chemistry / F. D. Gunstone. London: Chapman and Hall, 1996. 252 p". Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/99752.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

34

Marsura, Lucia <1996&gt. "La disclosure sul capitale intellettuale nella Relazione sulla gestione dopo il D. Lgs. 254/2016". Master's Degree Thesis, Università Ca' Foscari Venezia, 2020. http://hdl.handle.net/10579/18074.

Pełny tekst źródła

Streszczenie:

Negli ultimi decenni le imprese sono state coinvolte da due aspetti rilevanti. Il primo concerne il passaggio da un’economia industriale a una basata sulla conoscenza. Il capitale intellettuale (CI) ha assunto una crescente importanza all’interno del processo di creazione di valore delle imprese, fino a diventare il protagonista alla base del vantaggio competitivo. Il secondo riguarda la responsabilità sociale diventata sempre più pervasiva nella realtà aziendale. Sia il legislatore italiano, tramite delle generiche richieste all’interno della Relazione sulla gestione, sia organismi professionali, tramite linee guida e raccomandazioni, hanno cominciato a incentivare le imprese ad una maggiore responsabilizzazione. Il D. Lgs. n. 254/2016 esige la presentazione di una Dichiarazione di carattere non finanziario (DNF) i cui temi sono connessi al concetto di CI. La DNF segna il punto di svolta all’interno del processo di inclusione dei cosiddetti elementi Environmental, Social and Governance nei sistemi di rendicontazione delle grandi imprese. Il legislatore ha lasciato ampia libertà circa la comunicazione della DNF che può essere redatta in una specifica sezione all’interno della Relazione sulla gestione o in un documento a parte. L’obiettivo del presente lavoro è scoprire le scelte compiute dalle imprese in merito alle nuove disposizioni e capire, inoltre, se e come la comunicazione sia cambiata rispetto al passato in termini di CI.

Style APA, Harvard, Vancouver, ISO itp.

35

Guenther, Isabel. "The relationship between serum leptin, 25-hydroxyvitamin D₃, and body composition". Connect to this title, 2008. http://scholarworks.umass.edu/theses/196/.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

36

Herdick, Michaela. "Modulation der Interaktion von Vitamin D3-Rezeptor-Komplexen mit Kernproteinen durch 1[alpha],25(OH)2D3 [1 alpha,25(OH) 2 D 3] und 1[alpha],25(OH)2D3-Analoge [1 alpha,25(OH) 2 D 3-Analoge]". [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=960407987.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

37

Bella, Leonardo Mendes. "Estudo da suplementação de vitamina D em modelo experimental de diabetes mellitus". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04052015-090905/.

Pełny tekst źródła

Streszczenie:

O diabetes mellitus (DM) é uma doença com prevalência e morbidade elevadas em todo o mundo, sendo que o DM1 é responsável por 5-10% dos casos. A vitamina D, hormônio de ação pleiotrópica, pode melhorar o curso do DM1, embora os mecanismos não estejam completamente elucidados. Dessa forma, ampliar o conhecimento sobre a ação desse hormônio pode auxiliar no prognóstico, bem como na compreensão dos possíveis mecanismos envolvidos na prevenção do DM. Neste trabalho, foram avaliados os efeitos fisiológicos da suplementação de vitamina D (800 UI/dia/sete dias; via oral) em camundongos machos (n=31; linhagem C57BL/6) distribuídos em quatro grupos: Controle + Água (CA; n=9); Controle + Vitamina D (CV; n=9); Diabético + Água (DA; n=6) e Diabético + Vitamina D (DV; n=7). Os camundongos tornados diabéticos (aloxana, 60 mg/Kg, intravenosa), quando comparados aos controles, exibiram redução do peso corporal e concentrações plasmáticas de glicose mais elevadas durante o período experimental de 10 dias (características do estado insulinopênico). Entretanto, a suplementação com vitamina D não alterou essa condição. Camundongos tornados diabéticos, em relação aos controles, exibiram redução do peso corporal (p<0,05) e concentrações plasmáticas de glicose (p<0,001) mais elevadas durante o período experimental. Animais suplementados com vitamina D apresentaram, em relação aos controles, níveis de 25(OH)D mais elevados (CA vs CV, p<0,001; DA vs DV, p<0,001). Níveis séricos maiores de ureia (CA vs DA, p<0,05; CA vs DV, p<0,01; CV vs DA, p<0,05; CV vs DV, p<0,01) e creatinina (CA vs DA, p<0,001; CA vs DV, p<0,001; CV vs DA, p<0,001; CV vs DV, p<0,001), espessamento da cápsula de Bowman, hipertrofia glomerular e destruição de hepatócitos foram observados em camundongos diabéticos em relação aos controles. Entretanto, a suplementação com vitamina D não alterou estas condições. O grupo DA apresentou menor nível sérico de albumina em relação aos grupos CA (p<0,05) e CV (p<0,05); níveis inferiores de hemoglobina (p<0,05) e hematócrito (p<0,05) em relação ao grupo DV; e menor leucometria (p<0,05) e mononucleares sanguíneos (p<0,05) em relação ao grupo CA. Os resultados sugerem que a vitamina D possa influenciar a resposta imunológica em animais diabéticos, modulando hematócrito, hemoglobina, bem como os níveis séricos de albumina
Diabetes mellitus (DM) is a disease with high prevalence and morbidity worldwide, and the DM1 is responsible for 5-10% of cases. The vitamin D hormone pleiotropic action, can improve the course of T1DM, although the mechanisms are not fully elucidated. Thus, better understanding the action of this hormone can aid in prognosis as well as in understanding the possible mechanisms involved in the prevention of diabetes. We evaluated the physiological effects of vitamin D (800 IU/day/seven days, v.o.) in male mice (n=31, C57BL/6 strain) divided into four groups: Control + Water (CW, n=9); Control Vitamin D + (CV n=9); Diabetic + Water (DW, n=6) Diabetic + Vitamin D (VD, n=7). The mice induced-diabetes by alloxan (60 mg/kg, i.v.), when compared to controls, exhibited reduced body weight and plasma glucose concentrations were higher during the experimental period of 10 days (features insulinopenic state). However, vitamin D supplementation did not alter this condition. Diabetic mice, compared to controls, exhibited reduced body weight (p<0,05) and plasma glucose concentrations (p <0.001) higher during the trial period. Animals supplemented with vitamin D showed higher levels of 25 (OH) D than controls (CW vs CV, p <0,001; DW vs DV, p<0,001). Higher serum urea (CW vs. DW, p <0,05; CW vs DV, p <0,01; CV vs DA, p <0,05; CV vs DV, p <0,01) and creatinine (CW vs. DW, p <0,001; CW vs DV, p <0,001; CV vs DW, p <0,001; CV vs DW, p <0,001), thickening of Bowman\'s capsule, glomerular hypertrophy and destruction of hepatocytes were observed in diabetic mice compared to controls. However, vitamin D supplementation did not alter these conditions. The DW group showed lower serum albumin compared to CW (p<0,05) and CV (p<0,05) groups; lower hemoglobin (p<0,05) and hematocrit (p <0,05) compared to the DV group; and lower leukocyte counts compared to CW (p <0,05) and mononuclear blood (p <0,05) compared to the CW group. The results suggest that Vitamin D may influence the immune response in diabetic animals, modulating hematocrit, hemoglobin and serum albumin

Style APA, Harvard, Vancouver, ISO itp.

38

Yousef, Fatimah Mohammadali. "Vitamin D Status and Breast Cancer in Saudi Arabian Women: Case Control Study". Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/202986.

Pełny tekst źródła

Streszczenie:

Vitamin D is an essential nutrient in the human diet. A unique property of vitamin D is that it can be produced by endogenous synthesis in the skin following sufficient Ultraviolet B (UVB) radiation. In fact, our understanding of this compound has changed, such that it is no longer consider a true vitamin, but rather a steroid hormone. De-identified data for this analysis were derived from women residing in Jeddah, Saudi Arabia who completed routine medical visits in the summer of 2009 at King Fahad Hospital (KFH). In Chapter 1,“THE ASSOCIATION BETWEEN VITAMIN D STATUS IN NORMAL WEIGHT VERSUS OBESE WOMEN RESIDING IN WESTERN SAUDI ARABIA” we evaluate the relationship between body size and serum 25(OH)D concentrations including the association between change in body size during adulthood and vitamin D status. This study examines whether the current weight and weight change since age 18 years are associated with vitamin D status. This study found that neither current weight nor adult weight gain were associated with vitamin D status in Saudi Arabian women. In chapter 2,“IS AVOIDING SUN EXPOSURE VIA SUN PROTECTION PRACTICES ASSOCIATED WITH LOW VITAMIN D STATUS IN SAUDI ARABIAN WOMEN?” we investigate whether women who avoid UV exposure have lower 25(OH)D concentrations than women who do not avoid exposure. UV exposure was defined by time in outdoor activities, use of protective clothing and sunscreen. This study demonstrated that avoiding UV exposure via indoor activity and the use of sunscreen or/and wearing protective clothing was not associated with vitamin D status. Chapter 3, “VITAMIN D STATUS AND BREAST CANCER IN SAUDI ARABIAN WOMEN: A CASE CONTROL STUDY” we examine if vitamin D status as assessed by serum concentrations of 25(OH)D would be lower in breast cancer cases as compared to controls. This study demonstrated that there is a significant relationship between higher serum concentrations of 25(OH)D and lower risk of breast cancer. Chapter 4, “IMPLICATIONS AND FUTURE DIRECTIONS” is presented a summary of key findings from the three studies in this dissertation to determine avenues of further research. The appendices consist of materials related to the dissertation work.

Style APA, Harvard, Vancouver, ISO itp.

39

Antonoglou, G. (Georgios). "Vitamin D and periodontal infection". Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526209166.

Pełny tekst źródła

Streszczenie:

Abstract The aim of the present study was to examine associations between serum 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D[(1,25(OH)2D]—the circulating and active forms of vitamin D—and periodontal infection. The data were gathered from a case-control study (63 periodontitis patients and 30 periodontally healthy controls) and an intervention study among individuals with type 1 diabetes mellitus (T1DM, 80 patients at the baseline and 65 after periodontal treatment). The periodontal data and the levels of serum 25(OH)D, 1,25(OH)2D and parathyroid hormone (PTH) were available. A third data set included periodontal data and the serum level of 25(OH)D of 1262 non-smoking and non-diabetic 30–49-year-old individuals (Health 2000 Survey). Serum 25(OH)D analyses were done using enzyme-linked immunoassay and radioimmunoassay, 1,25(O)2D analyses using enzyme-immunoassay after purification of 1,25(OH)2D by immunoextraction and PTH analyses using electrochemiluminescence immunoassay. In the case-control study individuals with a low serum 1,25(O)2D level were more likely to belong to the periodontitis group than to the periodontally healthy group and an inverse association was observed between serum 1,25(OH)2D and severity of periodontitis at the baseline of the intervention study. Serum 1,25(OH)2D increased significantly after periodontal treatment in the T1DM patients; a finding that was considered suggestive of a causal relationship between serum 1,25(OH)2D and periodontal infection. Also, serum PTH increased after periodontal treatment; this increase, which was statistically significant (p = 0.016) in patients with moderate or severe periodontitis, may partly account for the earlier observed post-treatment increase in serum 1,25(OH)2D level. Possible explanations for low serum 1,25(OH)2D in periodontal infection may be increased degradation of 1,25(OH)2D, increased use of 1,25(OH)2D, or decreased hydroxylation of 25(OH)D The association between serum 25(OH)D level and periodontal infection was weak, if existent. An inverse association between serum 25(OH)D and the severity of periodontal infection was observed only in the T1DM patients. Among individuals with low plaque level, those in higher 25(OH)D quintiles tended to have fewer teeth with deepened periodontal pockets than those in lower quintiles; a finding which was interpreted to mean a slight protective role of 25(OH)D against periodontal infection
Tiivistelmä Tutkimuksen tarkoituksena oli selvittää seerumin 25-hydroksivitamiini D:n [25(OH)D, D-vitamiinin varastomuoto] ja 1,25-dihydroksivitamiini D:n [1,25(OH)2D, D-vitamiinin aktiivinen muoto] tasojen yhteyttä parodontiumin alueen infektiosairauksiin. Tulokset perustuvat kolmeen tutkimusasetelmaan: tapaus-verrokki-tutkimus (63 parodontiitti-potilasta, 30 verrokkia), interventio-tutkimus [80 tyypin 1 diabetes mellitus (T1DM) potilasta, joista 65 osallistui seurantaan parodontologisen hoidon jälkeen] ja poikittaistutkimus Terveys 2000 tutkimuksen osa-aineistossa (1262 30-49 vuotiasta tupakoimatonta ei-diabeetikkoa). Tapaus-verrokki- ja interventiotutkimuksissa tutkittiin myös seerumin parathormoonin (PTH) yhteyttä parodontaali-infektioon sekä PTH:n vaikutusta seerumin 1,25(OH)2D tasoon infektion hoidon jälkeen. D-vitamiinin ja PTH:n tasot määritettiin immunologisin menetelmin. Yhteyksiä tutkittiin käyttäen vakioituja monimuuttujamalleja. Tapaus-verrokki-tutkimuksessa yksilöt, joilla seerumin 1,25(OH)2D taso oli alhainen, kuuluivat todennäköisemmin parodontiitti- kuin verrokkiryhmään. Interventiotutkimuksen alkutilanteessa seerumin 1,25(OH)2D:n ja parodontaali-infektion vaikeusasteen välillä vallitsi tilastollisesti merkittävä käänteinen yhteys ja taso nousi merkittävästi infektion hoidon jälkeen. Myös seerumin PTH taso nousi parodontaali-infektion hoidon jälkeen; nousu oli tilastollisesti merkittävä (p = 0.016) pitkälle edennyttä parodontiittia sairastavilla. Interventiotutkimuksen tulokset viittaavat kausaaliseen yhteyteen 1,25(OH)2D:n ja parodontaali-infektion välillä. Alhainen seerumin 1,25(OH)2D pitoisuus infektion vallitessa voi selittyä sen suurella käytöllä immuunipuolustukseen infektion aikana tai lisääntyneellä hajoamisella. Tason nousu hoidon jälkeen tukee edellä mainittua. PTH on 25(OH)D:n hydroksylaation pääsäätelijä ja 1,25(OH)2D:n nousua hoidon jälkeen voi osittain selittää myös seerumin PTH tason kohoaminen. Seerumin 25(OH)D:n ja parodontaali-infektion välillä havaittu yhteys oli heikko, mutta ei täysin sulje pois 25(OH)D:n suojaavaa vaikutusta. Käänteinen yhteys löytyi vain interventiotutkimuksen alkutilanteessa T1DM potilailla. Infektion hoito ei vaikuttanut 25(OH)D tasoon. Terveys 2000 tutkimuksen osa-aineistossa havaittiin hyvän suuhygienian omaavilla jonkin verran alhaisempi määrä syventyneitä ientaskuja ylemmissä kuin alemmissa 25(OH)D kvintiileissä

Style APA, Harvard, Vancouver, ISO itp.

40

Borradale, David. "Investigating the links between muscle strength, sun exposure, dietary vitamin D intake and the vitamin D status of ambulatory older adults in South East Queensland". Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/26359/1/David_Borradale_Thesis.pdf.

Pełny tekst źródła

Streszczenie:

Vitamin D deficiency and insufficiency are now seen as a contemporary health problem in Australia with possible widespread health effects not limited to bone health1. Despite this, the Vitamin D status (measured as serum 25-hydroxyvitamin D (25(OH)D)) of ambulatory adults has been overlooked in this country. Serum 25(OH)D status is especially important among this group as studies have shown a link between Vitamin D and fall risk in older adults2. Limited data also exists on the contributions of sun exposure via ultraviolet radiation and dietary intake to serum 25(OH)D status in this population. The aims of this project were to assess the serum 25(OH)D status of a group of older ambulatory adults in South East Queensland, to assess the association between their serum 25(OH)D status and functional measures as possible indicators of fall risk, obtain data on the sources of Vitamin D in this population and assess whether this intake was related to serum 25(OH)D status and describe sun protection and exposure behaviors in this group and investigate whether a relationship existed between these and serum 25(OH)D status. The collection of this data assists in addressing key gaps identified in the literature with regard to this population group and their Vitamin D status in Australia. A representative convenience sample of participants (N=47) over 55 years of age was recruited for this cross-sectional, exploratory study which was undertaken in December 2007 in south-east Queensland (Brisbane and Sunshine coast). Participants were required to complete a sun exposure questionnaire in addition to a Calcium and Vitamin D food frequency questionnaire. Timed up and go and handgrip dynamometry tests were used to examine functional capacity. Serum 25(OH)D status and blood measures of Calcium, Phosphorus and Albumin were determined through blood tests. The Mean and Median serum 25-Hydroxyvitamin D (25(OH)D) for all participants in this study was 85.8nmol/L (Standard Deviation 29.7nmol/L) and 81.0nmol/L (Range 22-158nmol/L), respectively. Analysis at the bivariate level revealed a statistically significant relationship between serum 25(OH)D status and location, with participants living on the Sunshine Coast having a mean serum 25(OH)D status 21.3nmol/L higher than participants living in Brisbane (p=0.014). While at the descriptive level there was an apparent trend towards higher outdoor exposure and increasing levels of serum 25(OH)D, no statistically significant associations between the sun measures of outdoor exposure, sun protection behaviors and phenotypic characteristics and serum 25(OH)D status were observed. Intake of both Calcium and Vitamin D was low in this sample with sixty-eight (68%) of participants not meeting the Estimated Average Requirements (EAR) for Calcium (Median=771.0mg; Range=218.0-2616.0mg), while eighty-seven (87%) did not meet the Adequate Intake for Vitamin D (Median=4.46ug; Range=0.13-30.0ug). This raises the question of how realistic meeting the new Adequate Intakes for Vitamin D is, when there is such a low level of Vitamin D fortification in this country. However, participants meeting the Adequate Intake (AI) for Vitamin D were observed to have a significantly higher serum 25(OH)D status compared to those not meeting the AI for Vitamin D (p=0.036), showing that meeting the AI for Vitamin D may play a significant role in determining Vitamin D status in this population. By stratifying our data by categories of outdoor exposure time, a trend was observed between increased importance of Vitamin D dietary intake as a possible determinant of serum 25(OH)D status in participants with lower outdoor exposures. While a trend towards higher Timed Up and Go scores in participants with higher 25(OH) D status was seen, this was only significant for females (p=0.014). Handgrip strength showed statistically significant association with serum 25(OH)D status. The high serum 25(OH)D status in our sample almost certainly explains the limited relationship between functional measures and serum 25(OH)D. However, the observation of an association between slower Time Up and Go speeds, and lower serum 25(OH)D levels, even with a small sample size, is significant as slower Timed Up and Go speeds have been associated with increased fall risk in older adults3. Multivariable regression analysis revealed Location as the only significant determinant of serum 25(OH)D status at p=0.014, with trends (p=>0.1) for higher serum 25(OH)D being shown for participants that met the AI for Vitamin D and rated themselves as having a higher health status. The results of this exploratory study show that 93.6% of participants had adequate 25(OH)D status-possibly due to measurement being taken in the summer season and the convenience nature of the sample. However, many participants do not meet their dietary Calcium and Vitamin D requirements, which may indicate inadequate intake of these nutrients in older Australians and a higher risk of osteoporosis. The relationship between serum 25(OH)D and functional measures in this population also requires further study, especially in older adults displaying Vitamin D insufficiency or deficiency.

Style APA, Harvard, Vancouver, ISO itp.

41

Borradale, David. "Investigating the links between muscle strength, sun exposure, dietary vitamin D intake and the vitamin D status of ambulatory older adults in South East Queensland". Queensland University of Technology, 2008. http://eprints.qut.edu.au/26359/.

Pełny tekst źródła

Streszczenie:

Vitamin D deficiency and insufficiency are now seen as a contemporary health problem in Australia with possible widespread health effects not limited to bone health1. Despite this, the Vitamin D status (measured as serum 25-hydroxyvitamin D (25(OH)D)) of ambulatory adults has been overlooked in this country. Serum 25(OH)D status is especially important among this group as studies have shown a link between Vitamin D and fall risk in older adults2. Limited data also exists on the contributions of sun exposure via ultraviolet radiation and dietary intake to serum 25(OH)D status in this population. The aims of this project were to assess the serum 25(OH)D status of a group of older ambulatory adults in South East Queensland, to assess the association between their serum 25(OH)D status and functional measures as possible indicators of fall risk, obtain data on the sources of Vitamin D in this population and assess whether this intake was related to serum 25(OH)D status and describe sun protection and exposure behaviors in this group and investigate whether a relationship existed between these and serum 25(OH)D status. The collection of this data assists in addressing key gaps identified in the literature with regard to this population group and their Vitamin D status in Australia. A representative convenience sample of participants (N=47) over 55 years of age was recruited for this cross-sectional, exploratory study which was undertaken in December 2007 in south-east Queensland (Brisbane and Sunshine coast). Participants were required to complete a sun exposure questionnaire in addition to a Calcium and Vitamin D food frequency questionnaire. Timed up and go and handgrip dynamometry tests were used to examine functional capacity. Serum 25(OH)D status and blood measures of Calcium, Phosphorus and Albumin were determined through blood tests. The Mean and Median serum 25-Hydroxyvitamin D (25(OH)D) for all participants in this study was 85.8nmol/L (Standard Deviation 29.7nmol/L) and 81.0nmol/L (Range 22-158nmol/L), respectively. Analysis at the bivariate level revealed a statistically significant relationship between serum 25(OH)D status and location, with participants living on the Sunshine Coast having a mean serum 25(OH)D status 21.3nmol/L higher than participants living in Brisbane (p=0.014). While at the descriptive level there was an apparent trend towards higher outdoor exposure and increasing levels of serum 25(OH)D, no statistically significant associations between the sun measures of outdoor exposure, sun protection behaviors and phenotypic characteristics and serum 25(OH)D status were observed. Intake of both Calcium and Vitamin D was low in this sample with sixty-eight (68%) of participants not meeting the Estimated Average Requirements (EAR) for Calcium (Median=771.0mg; Range=218.0-2616.0mg), while eighty-seven (87%) did not meet the Adequate Intake for Vitamin D (Median=4.46ug; Range=0.13-30.0ug). This raises the question of how realistic meeting the new Adequate Intakes for Vitamin D is, when there is such a low level of Vitamin D fortification in this country. However, participants meeting the Adequate Intake (AI) for Vitamin D were observed to have a significantly higher serum 25(OH)D status compared to those not meeting the AI for Vitamin D (p=0.036), showing that meeting the AI for Vitamin D may play a significant role in determining Vitamin D status in this population. By stratifying our data by categories of outdoor exposure time, a trend was observed between increased importance of Vitamin D dietary intake as a possible determinant of serum 25(OH)D status in participants with lower outdoor exposures. While a trend towards higher Timed Up and Go scores in participants with higher 25(OH) D status was seen, this was only significant for females (p=0.014). Handgrip strength showed statistically significant association with serum 25(OH)D status. The high serum 25(OH)D status in our sample almost certainly explains the limited relationship between functional measures and serum 25(OH)D. However, the observation of an association between slower Time Up and Go speeds, and lower serum 25(OH)D levels, even with a small sample size, is significant as slower Timed Up and Go speeds have been associated with increased fall risk in older adults3. Multivariable regression analysis revealed Location as the only significant determinant of serum 25(OH)D status at p=0.014, with trends (p=>0.1) for higher serum 25(OH)D being shown for participants that met the AI for Vitamin D and rated themselves as having a higher health status. The results of this exploratory study show that 93.6% of participants had adequate 25(OH)D status-possibly due to measurement being taken in the summer season and the convenience nature of the sample. However, many participants do not meet their dietary Calcium and Vitamin D requirements, which may indicate inadequate intake of these nutrients in older Australians and a higher risk of osteoporosis. The relationship between serum 25(OH)D and functional measures in this population also requires further study, especially in older adults displaying Vitamin D insufficiency or deficiency.

Style APA, Harvard, Vancouver, ISO itp.

42

Prosser, David Eric. "Modeling and mechanistic studies of the mitochondrial vitamin D¦3, 25-hydroxylase". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0003/NQ38327.pdf.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

43

Dahl, Anna. "25(OH)D-brist hos överviktiga barnoch ungdomar och desskorrelation till insulinresistens". Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207668.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

44

Hill, Natasha Tremayne. "Vitamin D receptor and 1alpha, 25-dihydroxyvitamin D3 mediated regulation of DeltaNp63alpha". Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1450456950.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

45

Penlou, Sébastien. "Préparation d'haptènes de la vitamine D et obtention d'anticorps monoclonaux anti 25 hydroxyvitamine D pour la mise au point d'un immunodosage simultané des deux 25 hydroxyvitamines D2 et D3". Phd thesis, Université Claude Bernard - Lyon I, 2004. http://tel.archives-ouvertes.fr/tel-00952865.

Pełny tekst źródła

Streszczenie:

Dans le but d'accéder à un radioimmunodosage simultané des 25-hydroxyvitamines D2 et D3, qui sont un bon indicateur de la quantité de vitamine D disponible dans l'organisme, 5 haptènes de la vitamine D de chaînons variables à fonction acide carboxylique terminale ont été préparés par hémisynthèse à partir de la chaîne latérale de la vitamine D2. Ces 5 haptènes ont été couplés à la sérum albumine bovine pour immuniser des souris, des rats et des lapins ou bien à l'histamine pour donner des traceurs radioactifs, marqués par l'iode (125I). Les animaux ont bien répondu en sécrétant des anticorps dirigés contre les deux 25-hydroxyvitamines D2 et D3 avec des reconnaissances presque identiques. Les cellules spléniques de 3 de ces rats ont pu être fusionnées avec un myélome de souris afin de les immortaliser. Deux hybridomes sécréteurs d'anticorps monoclonaux qui reconnaissent les deux vitamines similairement et ne croisent pas avec l'hormone 1α,25-dihydroxyvitamine D ont pu être sélectionnés.

Style APA, Harvard, Vancouver, ISO itp.

46

Fakler, Johannes, Antonia Grafe, Jamila Dinger, Christoph Josten i Gabriela Aust. "Perioperative risk factors in patients with a femoral neck fracture – influence of 25-hydroxyvitamin D and C-reactive protein on postoperative medical complications and 1-year mortality". Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206107.

Pełny tekst źródła

Streszczenie:

Background: This study examined the association of 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) with postoperative medical complications and one year mortality of elderly patients sustaining a low-energy cervical hip fracture scheduled for surgery. We hypothesized that vitamin D deficiency and CRP in these patients might be associated with an increased 1-year mortality. Methods: The prospective single-center cohort study included 209 patients with a low-energy medial femoral neck fracture; 164 women aged over 50 years and 45 men aged over 60 years. Referring to 1-year mortality and postoperative medical complications multiple logistic regression analysis including 10 co-variables (age, sex, BMI, ASA, creatinine, CRP, leukocytes hemoglobin, 25(OH)D, vitamin D supplementation at follow-up) was performed. Results: Vitamin D deficiency was prevalent in 87 % of all patients. In patients with severe (<10 ng/ml) and moderate (10–20 ng/ml) vitamin D deficiency one year mortality was 29 % and 13 %, respectively, compared to 9 % in patients with > 20 ng/ml 25(OH)D levels (p =0.027). Patients with a mild (CRP 10–39.9 mg/l) or active inflammatory response (CRP ≥ 40 mg/l) showed a higher one year mortality of 33 % and 40 % compared to 16 % in patients with no (CRP < 10 mg/l) inflammatory response (p = 0.002). Multiple logistic regression analysis identified CRP (OR 1.01, 95 % CI 1.00- 1.02; p = 0.007), but not 25(OH)D (OR 0.97, 95 % CI 0.89-1.05; p = 0.425) as an independent predictor for one year mortality. 20 % of patients suffered in-hospital postoperative medical complications (i.e. pneumonia, thromboembolic events, etc.). 25(OH)D (OR 0.89, 95 % CI 0.81–0.97; p = 0.010), but not CRP (OR 1.01, 95 % CI 1.00-1.02; p = 0.139), was identified as an independent risk factor. Conclusion: In elderly patients with low-energy cervical hip fracture, 25(OH)D is independently associated with postoperative medical complications and CRP is an independent predictor of one year mortality.

Style APA, Harvard, Vancouver, ISO itp.

47

Rockwell, Michelle S. "Vitamin D in Human Health and Performance: The Pursuit of Evidence-Based Practice in an Era of Scientific Uncertainty". Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/93168.

Pełny tekst źródła

Streszczenie:

Background: Calciferol (vitamin D) is an essential nutrient that can be synthesized in the skin upon exposure to ultraviolet-B (UVB) light, or obtained through dietary and supplement sources. Traditionally known for its role in bone metabolism, vitamin D is currently described as a pleiotropic hormone with genomic and non-genomic roles in most body tissues. Clinical practice guidelines related to vitamin D are inconsistent and controversial. The purpose of this dissertation was to describe current patterns of vitamin D-related clinical care in a variety of settings, and to evaluate the impact of vitamin D supplements on the health and performance of collegiate athletes, a group with high prevalence of low vitamin D (LVD). Methods: This dissertation consists of five studies: 1) a scoping review of the health services literature related to clinical management of vitamin D; 2) a retrospective analysis of clinical care following non-indicated vitamin D testing using electronic health record (EHR) data from a regional health system; 3) a survey study to assess vitamin D-related practices among National Collegiate Athletic Association (NCAA) Division I programs; 4) an open clinical trial to evaluate the efficacy of a specific vitamin D supplement protocol in treating collegiate basketball athletes with LVD; and 5) a randomized, double-blind clinical trial to determine health and performance effects of vitamin D supplements in collegiate swimmers participating in fall season training. Results: Substantial inconsistency in vitamin D-related care was observed throughout the first three studies. Exponential increases in vitamin D testing and treatment, and associated costs, were identified in the U.S. and several other countries. A high proportion of this care was considered non-indicated (i.e., counter to professional guidelines). A lower rate of non-indicated vitamin D-related services was conducted within the health system we studied, but a cascade of low value services followed non-indicated vitamin D testing. Vitamin D testing was regularly performed by more than 65% of NCAA programs. In basketball athletes, 10 weeks of daily vitamin D3 supplements (5000 or 10,000 IU based on initial vitamin D status) improved serum 25-hydroxyvitamin D [25(OH)D], the common biomarker of vitamin D status. In swimmers, a vitamin D supplement protocol (5,000 IU vitamin D3 daily for 12 weeks) was efficacious in attenuating a seasonal decline in 25(OH)D compared with placebo. Swimmers taking vitamin D supplements also showed greater improvements in strength, power, and fat free mass. In both athlete studies, taking vitamin D supplements was associated with higher free testosterone concentration. Conclusions: The provision of evidence-based care related to vitamin D is complicated by contradictory clinical practice guidelines, resulting in inconsistent and sometimes, non-indicated care. Focused research on specific populations at high-risk for LVD can inform best practices. Our results suggest that taking vitamin D supplements is an efficacious strategy for athletes to improve 25(OH)D, especially when UVB exposure is low, and to enhance strength and power in collegiate swimmers.
Ph.D.
Vitamin D is known as the “sunshine vitamin” since it can be synthesized by the human body when exposed to specific wavelengths of ultraviolet-B (UVB) light. Some foods and dietary supplements also contain vitamin D. A relationship between vitamin D and bone health is well-established, but emerging research has also associated vitamin D status with a number of different diseases and health problems, including cancer, cardiovascular disease, autoimmune conditions, and depression. Unfortunately, this research is currently inconclusive, and healthcare providers’ professional guidelines related to vitamin D are highly variable. Thus, providing evidence-based care related to vitamin D is complicated. This dissertation consists of a series of three research studies that describe healthcare providers’ vitamin D-related care considering the uncertain landscape, and two research studies that explore the role of vitamin D in collegiate athletes. We chose athletes since a high proportion of them have deficient or insufficient vitamin D status, and because some research has shown that this low vitamin D status affects athletic performance. Results of these studies showed that vitamin D-related health services such as blood testing have increased dramatically over the past 15 years, as have costs associated with these services. Opportunities to improve consistency and quality of care were observed in multiple settings. In the athlete studies, a high rate of vitamin D deficiency and insufficiency was observed among basketball athletes, and we identified vitamin D supplement treatment protocol effective in improving vitamin D status. In addition, swimmers who took vitamin D supplements performed better on strength and conditioning tests than those who took placebo supplements. A favorable relationship between testosterone concentrations and vitamin D status was shown in both basketball athletes and swimmers. Continuing to conduct research focused on specific populations can help healthcare providers develop consistent, high quality, evidence-based care related to vitamin D.

Style APA, Harvard, Vancouver, ISO itp.

48

Monticielo, Odirlei André. "Estudo dos polimorfismos BsmI e FokI do receptor da vitamina D e avaliação dos níveis séricos da 25-hidroxivitamina D em pacientes com lúpus eritematoso sistêmico". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/28358.

Pełny tekst źródła

Streszczenie:

Introdução: A vitamina D tem ações pleiotrópicas em muitas doenças crônicas. A expressão do receptor da vitamina D (VDR - vitamin D receptor) em diversas células do sistema imune reforça a possível influência da vitamina D nas doenças autoimunes. Polimorfismos genéticos localizados no gene VDR podem determinar alterações nos mecanismos de ação da vitamina D, porém com resultados ainda pouco conhecidos. O polimorfismo BsmI do gene VDR foi associado com lúpus eritematoso sistêmico (LES) em pacientes asiáticos. Estudos com pacientes lúpicos no Brasil ainda não foram realizados. Objetivos: Investigar a possibilidade dos polimorfismos BsmI e FokI do gene VDR aumentarem o risco para o desenvolvimento do LES e avaliar a possível associação destes polimorfismos com manifestações clínicas e laboratoriais da doença. Determinar os níveis séricos da 25-hidroxivitamina D [25(OH)D)] nos pacientes e investigar a possível associação das suas concentrações com os polimorfismos estudados e expressões clínicas e laboratoriais do LES. Materiais e métodos: Estudo caso-controle envolvendo 195 pacientes com LES e 201 controles saudáveis da mesma área geográfica. Foram pesquisados os polimorfismos BsmI e FokI do gene VDR. Os níveis séricos da 25(OH)D foram dosados nos casos. A genotipagem foi realizada por Restriction Fragment Length Polymorphism-Polimerase Chain Reaction (RFLP-PCR), usando primers e enzimas de restrição específicas para cada polimorfismo. A dosagem da 25(OH)D foi realizada por quimioluminescência. Os dados clínicos e laboratoriais foram coletados dos prontuários. Resultados: Não houve diferença estatisticamente significativa nas frequências genotípicas e alélicas dos polimorfismos BsmI e FokI entre casos e controles eurodescendentes. Não houve associação entre as manifestações clínicas e laboratoriais do LES e os polimorfismos estudados. Os níveis séricos médios da 25(OH)D foram de 25,51±11,43 ng/ml nos pacientes com LES. Quando os pacientes foram classificados pelo estado de vitamina D, a seguinte distribuição foi observada: 55 (30,4%) normais (≥30 ng/ml), 63 (34,8%) insuficientes (20-30 ng/ml), 52 (28,7%) deficientes (<20 ng/ml) e 11 (6,1%) com níveis criticamente baixos (<10 ng/ml). Cinquenta e seis por cento dos pacientes com deficiência estavam usando pelo menos 800 UI de vitamina D por dia. Baseada na distribuição genotípica, a concentração da 25(OH)D foi significativamente maior nos pacientes com genótipo f/f, quando comparados com os pacientes com genótipo F/F (31,614,1 ng/ml versus 23,09,2 ng/ml, p=0,004). Níveis de vitamina D não foram associados com aspectos clínicos e laboratoriais do LES. Conclusões: Os polimorfismos BsmI e FokI não apresentaram associação com LES nos nossos pacientes eurodescendentes estudados. O polimorfimo FokI mostrou influência significativa nos níveis da 25(OH)D, o que reforça o papel deste polimorfismo na atividade funcional do VDR. Este achado poderia ser considerado em futuros estudos clínicos e experimentais envolvendo dosagem da vitamina D. A concentração da 25(OH)D necessária para manter o bom funcionamento do sistema musculoesquelético, cardiovascular e imunológico deveria ser individualizada para cada paciente e novas orientações sobre a suplementação de vitamina D poderiam ter que levar em consideração a ancestralidade genética. Assim, estudos adicionais são necessários para estabelecer definições dos níveis ideais de vitamina D geneticamente especificados.
Introduction: Vitamin D has pleiotropic actions on many chronic diseases. The expression of the VDR (vitamin D receptor) in various cells of the immune system strengthens the possible influence of vitamin D on autoimmune diseases. Genetic polymorphisms located in VDR gene may determine changes in the mechanisms of action of vitamin D, but with results still unknown. The BsmI VDR polymorphism was associated with systemic lupus erythematosus (SLE) in Asian patients. Studies with SLE patients in Brazil have not been conducted. Objectives: To investigate the possibility of BsmI and FokI polymorphisms of VDR gene causing increased risk for development of SLE and to evaluate the possible association of these polymorphisms with clinical and laboratory manifestations of the disease. To determine serum levels of 25-hydroxyvitamin D [25(OH)D)] in patients and to investigate the possible association of their concentrations with the studied polymorphisms and clinical and laboratory expressions of SLE. Materials and methods: Case-control study involving 195 SLE patients and 201 healthy controls from the same geographical area. The BsmI and FokI polymorphisms of VDR gene were studied. Serum 25(OH)D levels were measured in the cases. Genotyping was performed by Restriction Fragment Length Polymorphism-Polymerase Chain Reaction (RFLP-PCR), using primers and restriction enzymes specific for each polymorphism. The measurement of 25(OH)D was performed by chemiluminescence. The clinical and laboratory data were collected from medical records. Results: There was no statistically significant difference in genotypic and allelic frequencies of BsmI and FokI polymorphisms among European-derived cases and controls. There was no association between clinical and laboratory features in SLE patients and the studied polymorphisms. The mean serum levels of 25(OH)D were 25.51±11.43 ng/ml in SLE patients. When patients were classified according to vitamin D status, the following distribution was observed: 55 (30.4%) had normal (≥30 ng/ml), 63 (34.8%) insufficient (20-30 ng/ml), 52 (28.7%) deficient (<20 ng/ml) and 11 (6,1%) critically low serum levels (<10 ng/ml). Fifty six percent of patients with deficiency received at least 800 IU of vitamin D per day. Based on genotype distribution, 25(OH)D levels were significantly higher in patients carrying the f/f genotype, when compared to patients carrying the F/F genotype (31.614.1 ng/ml versus 23.09.2 ng/ml, p=0.004). Vitamin D levels were not associated with clinical and laboratory features of SLE. Conclusions: The BsmI and FokI polymorphisms did not present association with SLE in our European-derived studied patients. The FokI polymorphism showed significant influence on 25(OH)D levels, reinforcing its role in functional activity of VDR. This finding may be considered in future clinical and experimental studies involving vitamin D measurements. Serum concentrations of 25(OH)D required to maintain optimal musculoskeletal, cardiovascular and immune health should be individualized for each patient and new guidelines about vitamin D supplementation may have to take into consideration the individual genetic background. Genetic-specific definitions of ideal levels of vitamin D in SLE should therefore be established in future studies.

Style APA, Harvard, Vancouver, ISO itp.

49

Rockell, Jennifer, i n/a. "Serum 25-hydroxyvitamin D concentrations and their determinants in the New Zealand population". University of Otago. Department of Nutrition, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080929.142611.

Pełny tekst źródła

Streszczenie:

Adequate vitamin D status plays an important role in bone health and may also protect against Type 1 Diabetes (T1D), multiple sclerosis and certain cancers. Vitamin D is obtained from two sources; diet and through skin synthesis through the action of ultraviolet (UV) light. Dietary intakes of vitamin D are low in New Zealand (NZ) and the majority of our vitamin D comes from UV exposure. The NZ population may be at risk of low vitamin D status because of low dietary intakes, the country�s latitude (35-46 �S), and high proportion of darker skinned Maori and Pacific People. While case reports have described the occurrence of rickets, predominantly in immigrant groups, there are currently no national data on the vitamin D status of the NZ population. Reports of low vitamin D status in countries of similar latitude to NZ justify an examination of New Zealanders� vitamin D status. The best method to assess of vitamin D status is to measure circulating 25-hydroxyvitamin D concentrations. This thesis comprises three main studies. The first two had the following aims: to measure 25-hydroxyvitamin D concentrations and their determinants in a national sample (n=1585) of NZ children aged 5-14 y and to measure serum 25-hydroxyvitamin D concentrations and their determinants in a national sample (n=2948) of New Zealanders aged 15 y and over. The 2002 Children�s Nutrition Survey CNS02 was a year long (December, March-November) cross-sectional survey of a nationally representative sample of NZ school children 5-14 y. Over-sampling of Maori and Pacific children allowed ethnic specific analyses. The 1997 National Nutrition Survey (NNS97) participants were recruited over one year according to an area-based sampling frame with a 3 stage stratified design consisting of primary sampling units, households within each unit, and one randomly selected respondent from each household. Mean (99% CI) serum 25-hydroxyvitamin D concentrations were similar in children and adults (both 50 nmol/L). Among Maori, Pacific and NZEO children respectively, prevalence (%, 99% CI) of serum 25-hydroxyvitamin D deficiency (< 17.5 nmol/L) was 5% (2, 12), 8% (5, 14), and 3% (1,7). Based on a cutoff of < 37.5 nmol/L, prevalence of insufficiency was 41% (29, 53), 59% (42, 75) and 25% (15, 35), respectively. Based on a cutoff of 50 nmol/L, 56% of children were insufficient. Three percent of adult New Zealanders had serum 25-hydroxyvitamin D concentrations indicative of deficiency ([less than or equal to] 17.5 nmol/L); 48% and 84% were insufficient based on cutoffs of [less than or equal to] 50 and [less than or equal to] 80 nmol/L The main determinants of vitamin D status in NZ children were season, ethnicity and sex. After adjustment for other factors and covariates, boys had an adjusted mean (99% CI) 25-hydroxyvitamin D concentration 5 (1, 9) nmol/L higher than girls, Maori children were 7 (2, 11) and Pacific children 15 (11, 20) nmol/L lower than NZ European and Other (NZEO) children. Obese children were 7 (2, 11) nmol/L lower than overweight or �normal� weight. Children�s mean 25-hydroxyvitamin D concentrations (adjusted for other variables) peaked in March (69 nmol/L) and was at its lowest in August (36 nmol/L). In adults, there were effects of a similar magnitude of ethnicity and season on serum 25-hydroxyvitamin D concentrations. Obesity, latitude and age were determinants of vitamin D status in women but not men. Obese (BMI > 30) women had an adjusted mean vitamin concentration 6 (3, 10) nmol/L lower than women with BMI < 25. Women living in the South Island were 6 (3, 9) nmol/L lower than women living in the North Island. Additionally, adjusted mean serum 25-hydroxyvitamin D was 13 (8, 18) higher in women 15 -18 y than women 65 y or older. The third and final study aimed to determine whether the higher rates of vitamin D inadequacy reported in the winter than summer months in NZ also result in higher PTH concentrations, which would provide evidence for functional effect of inadequate vitamin D status. We also aimed to objectively explore the effect of natural skin colour on vitamin D status, given the higher prevalence of vitamin D insufficiency in dark-skinned groups living far from the equator. Skin colour measurements were taken with a hand-held light reflectometer (Datacolor Mercury[TM] 1000 colorimeter, Lawrenceville, NJ). In the 342 residents of Invercargill and Dunedin, mean serum 25-hydroxyvitamin D concentrations were lower in the late summer versus early spring (79 vs 51 nmol/L; P< 0.001). The lower serum 25-hydroxyvitamin D in early spring versus summer was associatedwith a 2 pg/mL (P< 0.001) higher parathyroid hormone (PTH) concentration. Interestingly, no significant effect of natural skin colour, based on light reflectance at the inside of the upper arm, was discovered, though there was a positive effect of tanning, based on light reflectance at the upper forearm, on serum 25-hydroxyvitamin D concentrations. Ethnicity and season are major determinants of serum 25-hydroxyvitamin D in New Zealanders. There is a high prevalence of vitamin D insufficiency in NZ children and adults, which may contribute to increased risk of osteoporosis and other chronic disease. While there is a pressing need for more convincing evidence with regards to the health risks associated with the low vitamin D status in children, evidence from the study of adults, where higher PTH concentrations were found during spring versus summer, suggests that the low 25-hydroxyvitamin D concentrations are having an adverse effect on bone health of adults. The high prevalence of vitamin D insufficiency in New Zealanders, warrants serious consideration of strategies such as fortification, to improve the vitamin D status of the population.

Style APA, Harvard, Vancouver, ISO itp.

50

Byrd, Alyson. "Evidence for a receptor binding 24R,25-dihydroxyvitamin D¦3 in developing bone". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0022/MQ50730.pdf.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

Rozprawy doktorskie na temat „D-256”

Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych