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1
White, Gemma. "The role of fractalkine (CX₃CL1) and its receptor (CX₃CR1) in vascular biology". Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670108.
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Johansson, Alexander. "Produktionsanpassa ny konstruktionav en HD-topp på Cx-plog". Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-23692.
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Överums bruk AB är idag en ledande tillverkare av jordbruks maskiner där främst Europa är största marknaden. Deras främsta produkt är vändskiveplogen som är världsledande just nu på marknaden med lågt dragkrafts behov och hög effektivitet. Då konkurrensen ökar och kostnaderna inte minskar så krävs anpassning av nya konstruktioner till produktionen för att få ner kostnaderna men även minska antalet olika detaljer. I det här projektet utgår jag utifrån ett förslag på en ny huvudkomponent kallad topp till Cx-plogen. Den ska ersätta den gamla toppen men även den spanska toppen som används på den spanska marknaden. HD-toppen sitter längst fram på vändskiveplogen och dess funktion är att lyfta, dra och hålla upp plog ramen. Först gjordes en grundlig genomgång av processen så att problem och förbättringsmöjligheter upptäcks. Sedan gjordes olika beräkningar för att på så sätt få fram hur mycket man tjänade på de förändringar som gjordes. Slutsatsen är att kostnaderna är väldigt beroende av bearbetningstiden men också på vilken kapacitet som finns. Med kapacitet menar då produktions förmåga till anpassning till att göra olika moment för många produkter effektivt. En av slutsatserna av det här arbetet är att det ofta är svårt att konkurrera med företag som tillverkar special detaljer till olika industrier. Alltså det som kallas legotillverkning. Det är då i många fall bäst att skicka över en del moment i produktionen av detaljer till legotillverkare som gör det mer effektivt med andra maskiner för att det företaget kan vara expert på en viss tillverkningsprocess. På så sätt kan man reducera totala kostnaden på produkten. Ytterligare slutsatser av det här arbetet, är att kvalitets problem kan betyda stora kostnader om man inte åtgärdar det. Inga stora kostnader upptäcktes i arbetet men på lång sikt kan det bli ekonomiskt oförsvarbart. Då menas att kostnaderna kan öka okontrollerat till en nivå som direkt påverkar totala ekonomin för Överums brukÖverums Bruk AB is a leading manufacturer of agricultural machinery where primarily Europe's largest market. Their main product is the mouldboardplough, the world leader right now in the market with low draft requirement needs and high efficiency. As competition increases and the costs are not reduce the required adaptation of new designs to production in order to bring down costs but also reduce the number of different parts.In this project, I start by on a proposal for a new main component called top to the Cx-plough. It will replace the old top but also the Spanish top used in the Spanisk market. The top is seated at the fron of the mouldboardplough and its purpose is to lift, pull and hold up the plough frame. First, a thorough review of the process so that problems and improvement opportunities could be identified.I worked on with various calculations in order to conceive how much you could earn on the changes made. The conclusions is that the costs are very dependent on the processing time but also on the capacity available. With the capacity I mean the production capacity to adapt to make various parts for many products more effectively.One of my conclusions from special work is that it is often difficult to compete with companies that makes special parts for various industries. So what are known as contract manufacturing. It is the best in many cases to send over some elements of the production of details to contract manufacturer that makes them more effectively with other machines for the company to be experts on a certain manufacturing process. That way you can reduce the overall cost of the product.Additional findings of this study is that quality problems can mean significant costs if you do not fix it. No sized costs were discovered in the work but in the long run it may be economically indefensible. This meant that cost could increase uncontrollably to a level that directly affects the overall economics of Överums bruk.
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Durkan, Anne Maria. "The expression of CX₃CL1 (fractalkine) in renal tubular epithelial cells and the regulation of CX₃CL1 by stimulation of the thromboxane prostanoid receptor". Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/24546.
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Most renal diseases have a common end inflammatory pathway, which is associated with a leukocytic infiltrate. Chemokines are small proteins that are responsible for the chemoattraction of leukocytes into areas of injury or insult. CX3CL1, also known as fractalkine, exists as a transmembrane protein as well as a soluble protein. It acts as a cell adhesion molecule in addition to its chemoattractant properties. This thesis firstly examines the distribution of CX3CL1 in renal tubular epithelial cells (RTEC) and in the second part of the thesis the regulation of CX3CL1 by stimulation of the thromboxane prostanoid (TP) receptor is examined. The localisation of CX3CL1 was initially demonstrated primarily on the apical surface of tubular epithelial cells in human renal biopsy specimens with histological diagnoses of acute tubular necrosis and acute allograft rejection. A cell model was then developed in MDCK cells to examine the distribution more closely. There are a limited number of mechanisms potentially responsible for the trafficking of CX3CL1 to the apical membrane and it was established that N-glycosylation of CX3CL1 is required for its presence on the apical membrane of RTEC. The mobility of CX3CL1 within the cell membrane was next assessed and it was shown to be relatively immobile. We hypothesized that this would promote cell adhesion and indeed further experiments confirmed that CX3CL1 in RTEC does promote adhesion of cells bearing the cognate receptor. Given that CX3CL1 and thromboxane A2 are both found in similar inflammatory conditions, are both present early in the inflammatory process and that stimulation of the TP receptor has been shown to regulate other chemokines, we next evaluated the effect of stimulation of TP on CX3CL1. We found that both total and surface cellular levels of CX3CL1 were reduced following stimulation of TP. A maximal nadir was present after 30-60 minutes and the levels returned to baseline by 4 hours. The mechanism for the loss of CX3CL1 was then assessed. CX3CL1 is known to recycle between the cell surface and an internal compartment. No effect of TP stimulation was seen on the endocytosis or exocytosis of CX3CL1. Stimulation of TP was however, shown to stimulate tumour necrosis factor-a converting enzyme (TACE) via ERK phosphorylation. TACE inducibly cleaves CX3CLI, releasing the soluble chemokine. TACE siRNA was used to knock down TACE gene expression and this prevented the loss of cellular CX3CL1, confirming that TP stimulation induces TACE cleavage of CX3CL1. T he results of further experiments are discussed in the discussion chapter.
4
Rüttinger, Christina. "Untersuchungen zur Expression von Connexin (Cx)43 und Connexin (Cx)45 in Sertoli-Zellen und Keimzellen in der normalen Spermatogenese, Sertoli-Zelltumoren und Seminomen des Hundes". Giessen : VVB Laufersweiler, 2008. http://d-nb.info/989910296/34.
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Rüttinger, Christina [Verfasser]. "Untersuchungen zur Expression von Connexin (Cx)43 und Connexin (Cx)45 in Sertoli-Zellen und Keimzellen in der normalen Spermatogenese, Sertoli-Zelltumoren und Seminomen des Hundes / eingereicht von Christina Rüttinger". Giessen : VVB Laufersweiler, 2008. http://d-nb.info/989910296/34.
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Goldstein, P. "K-theoretic classification of canonical Z2-actions on certain purely infinite Cx-algebras". Thesis, Swansea University, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.637069.
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Canonical Z2-actions on certain C*-algebras are investigated. The algebras under consideration are C* -algebras on generators and relations associated to directed graphs, and, depending on the graph, they are shown to be either AF or purely infinite and simple. The class of graph C* -algebras contains Cuntz-Krieger algebras OA and the Cuntz algebra O∞, and can be regarded as a generalisation of those, corresponding to countably infinite matrices. Dynamical systems of the form (OA, α), where OA is an even Cuntz-Krieger algebra, and α the above canonical symmetry, are considered. If the pair (OA, α) satisfies certain conditions, it is shown to be classified by the following K-theoretic invariant: The proof uses the Rokhlin property of the canonical endomorphism on OA. It is shown that such a pair (OA, α) is isomorphic to the inductive limit system lim→ (An, αn), where each An is a direct sum of matrix algebras over even Cuntz algebras, and αn the canonical symmetry. Dynamical systems of the form (O∞, α) and (O∞β) are isomorphic. The proof is based on the corresponding results for the actions on Cuntz algebras, and approximate absorption.
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Hafar, Matthew Alan. "The psalmody of Monteverdi : choral settings of the vesper psalms CX and CXI". Diss., University of Iowa, 1992. https://ir.uiowa.edu/etd/6031.
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Sebastiani, Andrea. "Decomposizione CUR per una migliore analisi dei dati". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/14548/.
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Le tecniche comunemente utilizzate nell'analisi dei dati permettono di esprimere grandi matrici di dati in termini di un insieme di alcuni vettori ortogonali detti componenti principali. Solitamente questi vettori, essendo combinazioni lineari delle colonne e delle righe della matrice, risultano difficili da interpretare in termini del processo da cui provengono i dati. In questa tesi viene presentata e studiata la decomposizione CUR che permette di rappresentare la matrice in termini di alcune righe e/o colonne della matrice stessa. Tale proprietà rende più facile l'interpretazione dei risultati in termini dei dati di partenza. In particolare vengono presentati due algoritmi randomizzati per il campionamento delle righe/colonne della matrice e per la costruzione delle matrici della decomposizione. La tecnica utilizzata per il campionamento è una particolare strategia chiamata "subspace sampling" che permette di dimostrare l'esistenza di garanzie di tipo probabilistico per l'errore della decomposizione. Infine vengono presentati i risultati della riduzione delle informazioni di un dataset, proveniente da una directory web, ottenuta mediante la decomposizione CUR.
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Yilmaz, Bertan. "Customer Analytics and Cluster Analysis : A Clustering Application for CustomerSegmentation Based on CX Data". Thesis, Uppsala universitet, Tillämpad matematik och statistik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-377522.
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Montalti, Nicolas. "Prove di fatica a flessione rotante su provini in acciaio inossidabile CX realizzati con processo di Additive Manufacturing". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
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Sono state eseguite prove di fatica a flessione rotante su un acciaio inox ottenuto per DMLS (Direct Metal Laser Sintering) studiando l'effetto sulla vita a fatica risultante dalla lavorazione a macchina utensile.
I provini avevano forma cilindrica a clessidra; essi sono stati micro-pallinati e non hanno subito trattamenti termici. Sono state analizzate due configurazioni: un lotto di provini è stato lavorato alle macchine utensili, il secondo no.
Le norme utilizzate per realizzare lo studio sono la ISO 12107 e la ISO 1143.
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Fregnani, Cristiane Menezes Sirna. "Propriedades psicométricas de dois instrumentos para avaliação da qualidade de vida relacionada à saúde em mulheres com câncer de colo de útero". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/22/22133/tde-23052014-124457/.
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O câncer de colo do útero é o segundo tumor mais frequente entre as mulheres brasileiras, os tratamentos disponíveis trazem complicações de curto a longo prazo e estudos que avaliam a qualidade de vida destas mulheres ainda são escassos no Brasil. Isto é justificado pela falta de instrumentos específicos e validados para esta finalidade em língua portuguesa (Brasil). Neste estudo objetivou-se testar as propriedades psicométricas dos questionários EORTC QLQ-CX24 e FACT-CX em uma amostra de mulheres brasileiras com câncer do colo do útero. O estudo é metodológico e foi realizado com 100 mulheres tratadas no Hospital de Câncer de Barretos, por meio de três avaliações (no início do estudo, 15 dias e 18 a 24 meses após o início). Foi testada a consistência interna (alfa de Cronbach), reprodutibilidade (coeficiente de correlação intraclasse), validade convergente (correlação com o questionário SF-36 e com o questionário EORTC QLQ-C30), a validade discriminante pelo estadiamento, tipo de tratamento e autoclassificação de saúde e a responsividade pelo método de distribuição dos dados, além da análise da facilidade de compreensão das questões e dos questionários. Confirmou-se a confiabilidade do questionário EORTC QLQ-CX24, a reprodutibilidade foi baixa nas escalas de preocupação sexual, atividade sexual e prazer sexual, bons resultados observou-se ao avaliar a validade convergente e discriminante. A análise da responsividade não confirmou todas as hipóteses. Ao avaliar o questionário FACT-CX, por meio da consistência interna, exceto pela escala de bem-estar emocional, as demais apresentaram valores de Alpha de Cronbach superiores a 0,70. A reprodutibilidade foi satisfatória nas cinco escalas que compõem o FACT- CX. Na análise da validade convergente, somente as escalas de bem-estar físico e bem-estar emocional mostrou boa correlação com as escalas do SF-36. Em geral, o questionário revelou boa validade discriminante, principalmente em relação a autoclassificação da saúde. Resultado satisfatório encontrou-se na análise da responsividade. Em geral observou-se um bom grau de entendimento das questões e dos questionário. Concluindo os questionários desenvolvidos para medir a QVRS em mulheres com câncer de colo do útero EORTC QLQ-CX24 e FACT-CX obtiveram resultados aceitáveis recomendando-se que outros estudos testem a responsividade por outros métodosCervical cancer is the second most common tumor among Brazilian women. Available treatments bring short and long-term complications, and studies assessing the quality of life of these women are still rare in Brazil. Such situation is warranted by the lack of specific and validated tools in (Brazilian) Portuguese for such a purpose. The goal of this study was to test the psychometric properties of EORTC QLQ-CX24 and FACT-CX questionnaires in a sample of Brazilian women affected by cervical cancer. This is a methodological study and it was conducted on 100 women treated at the Barretos Cancer Hospital by way of three assessments (at baseline, 15 days and 18 to 24 months after the onset). We tested the internal consistency (Cronbach\'s alpha), reproducibility (intraclass correlation coefficient), convergent validity (correlation with the SF-36 questionnaire and the EORTC QLQ-C30 questionnaire), the discriminant validity by way of staging, type of treatment and health self-classification and responsiveness by the method of data distribution, as well as the analysis of how easy it was their understanding of questions and questionnaires. The reliability of the EORTC QLQ-CX24 questionnaire was confirmed, reproducibility was low in the scales of sexual worry, sexual activity and sexual enjoyment, and good results were observed when evaluating the convergent and discriminant validity. The analysis of responsiveness did not confirm all hypotheses. Upon evaluation of the FACT-CX questionnaire through internal consistency, except for the scale of emotional well-being, the others showed Cronbach\'s alpha values above 0.70. Reproducibility was satisfactory in the five scales comprising FACT-CX. In convergent validity analysis, only the scales of physical well-being and emotional well-being showed good correlation with the scales of the SF-36. In general, the questionnaire demonstrated good discriminant validity, especially in relation to the self-ratings of health. Satisfactory result was found in the analysis of responsiveness. In general there was a good degree of understanding of questions and questionnaires. In conclusion, questionnaires developed to measure HRQOL in women with cervical cancer such as EORTC QLQ-CX24 and FACT-CX achieved acceptable results, and we do recommended that further studies are performed to assess responsiveness by other methods
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Miranda, da Rocha Ferreira Erliane. "Medicalização da vida como cuidado de si : pondera 20mg/10mg repasso 10 cx, por um ótimo preço!" Universidade Federal de Pernambuco, 2009. https://repositorio.ufpe.br/handle/123456789/9260.
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Previous issue date: 2009Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Essa dissertação tem como objeto o consumo contemporâneo de psicofármacos dos tipos ansiolítico e antidepressivo. A abordagem focaliza três temas para pensar esse objeto: i) o cuidado de si; ii) a medicalização da vida; iii) a cultura do consumo. Orientada em suas linhas gerais pelos estudos da sociologia da técnica, da saúde e da modernidade, a noção de cuidado de si de Michel Foucault é tomada como o eixo a partir do qual se busca entender o controle paulatino dos estados psicoafetivos humanos a fim de se compreender o significado contemporâneo do consumo de psicofármacos. Neste sentido, o objetivo geral dessa pesquisa foi investigar em que medida o consumo de psicofármacos corresponderia a uma forma de cuidado de si ou meramente um meio para a docilização dos corpos . O resultado obtido com a investigação empírica foi de que, embora o consumo de psicofármacos contenha elementos que remetem ao cuidado de si, especialmente no que diz respeito à inquietação que produz a reflexividade, algo se perdeu no processo de modernização. Diferentemente do cuidado de si, que depende da aprendizagem pelo erro e pela dor para a construção de uma subjetividade calcada na reflexão e na possibilidade da transformação de si, a reflexividade associada ao consumo de psicofármacos é contingente e localizada, impondo limites à reflexão e, portanto, ao autogoverno
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Simpson, Charlotte Louise. "Molecular mechanisms regulating the epithelial barrier : key roles for Cx26 and ADAM17 during bacterial infection". Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9059.
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This study investigated how gastrointestinal and skin bacterial infections were affected by differential expression of connexin (Cx) 26 and a disintegrin and metalloprotease (ADAM) 17 in vitro. Cx26 is a component of gap junctions, which facilitate the transfer of small molecules between two cells. Recessive mutations in Cx26 cause non syndromic hearing loss (NSHL), and in certain populations, specific mutations account for the majority of Cx26 related NSHL. Their common occurrence suggests that they may provide a heterozygous, protective advantage to carriers. In this study adherence by the attaching and effacing pathogen Enteropathogenic Escherichia coli (EPEC) was significantly reduced in cells expressing mutant Cx26 compared to wild type Cx26. Furthermore, EPEC adherence and invasion of an alternative enteric pathogen, Shigella flexneri were reduced following treatment with Cx26 short-interfering-RNA in intestinal cells. These findings suggest that the loss of functional Cx26 expression improves protection against enteric bacteria. ADAM17 releases substrates including tumour necrosis factor alpha and ligands of the epidermal growth factor receptor and therefore is involved in the induction of immune responses and maintenance of the epidermal barrier. This study demonstrated that ADAM17 provides protection during Staphylococcus aureus infection of keratinocytes. Subsequently the protective effects of ADAM17 mediated protection were explored. Secretion of the proinflammatory cytokines Interleukins 6 and 8 correlated with ADAM17 activity. Additionally gene expression profiling was performed which identified the IL-17 signalling pathway, which is known to be important during S. aureus infection, as a potential downstream target of ADAM17. In summary, based on these findings, Cx26 and ADAM17 may represent potential therapeutic targets for gastrointestinal and skin bacterial pathogens.
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TOTAL, ALINE. "Activation de liaisons cc, ch et cx (x=o, n) par le monocation metallique al#+. Approches theorique et experimentale". Paris 6, 1993. http://www.theses.fr/1993PA066478.
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L'objectif de ce travail est l'etude de la reactivite en phase gazeuse de complexes organometalliques formes entre le monocation al#+ et divers composes organiques contenant comme centre actif un atome d'oxygene ou d'azote. Ce manuscrit se compose de deux parties. Dans une premiere, sont decrites les methodologies theorique et experimentale utilisees dans cette etude. Dans une deuxieme partie, les deux premiers chapitres presentent sous la forme de deux articles, les resultats relatifs a: 1) l'etude theorique et experimentale de la complexation par al#+ de l'oxiranne, l'acetaldehyde et l'alcool vinylique; 2) l'etude theorique de la complexation par al#+ d'une serie de composes azotes: l'aziridine, la vinylamine, la n- et c-methylmethyleneimine et le carbene aminoethylidene. Dans les deux premiers chapitres de cette seconde partie sont rassemblees et analysees les donnees experimentales concernant la reactivite du cation al#+ vis-a-vis de bases oxygenees heterocycliques et aliphatiques obtenues a partir d'experiences realisees sur un spectrometre de masse a resonance cyclotronique ionique a transformees de fourier et sur un spectrometre a secteurs. L'ensemble de ce travail a permis d'evaluer les energies de complexation et la stabilite des differents isomeres. Il a egalement ete mis en evidence des activations des liaisons des bases considerees
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ElHarthy, Kamal. "Alternativ för kreosotimpregnerade stolpar för Skellefteå Kraft AB : Med energiteknisk kalkyl för utsläpp vid impregnering och transport av kreosotstolpar". Thesis, Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-66487.
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Kreosot är ett träskyddsmedel som förstärker träet mot röta och levande organismer vid impregnering. Problemet är att ämnet kreosot klassas som hälsofarligt och påverkar miljön i flera aspekter. Kemikalieinspektionen har beslutat om en förlängd användning av ämnet fram till år 2018. Därefter riskerar bekämpningsmedlet en gradvis utfasning i hela landet. En stor del av elkraftstolparna som Skellefteå Kraft AB använder i deras elnät är kreosotimpregnerade stolpar. Vid utfasning av ämnet kommer företaget att behöva ha en ny strategi angående elkraftstolpar. Med hjälp av undersökningar och analyser ska denna rapport beskriva en lämplig strategi för Skellefteå Kraft AB att använda sig av när kreosot förbjuds. På grund av de goda egenskaperna hos materialet trä och dess låga belastning på miljön avgränsas rapporten för just undersökning av metoder och medel som endast involverar materialet trä, bland annat furu på grund av dess goda förmåga vid inträngning av träskyddsmedlet. Rapporten undersöker först miljöpåverkan för kreosotstolpar genom studier av så kallade livscykelanalyser (LCA). En sådan undersökning inkluderar alla utsläpp som uppstår under en kreosotstolpes livslängd och dess påverkan på naturen och människan. Här utfördes en energiteknisk beräkning av det totala utsläppet för två olika exempel, en kortare (150 mil) och en längre (500 mil). Resultatet av denna analys visar att energiåtgången var bara ca 1/3 högre för den längre transporten. Det största utsläppet var växthusgasen koldioxid vilket skedde i betydligt större omfattning för den längre transportsträckan. Rapporten fortsätter att undersöka vilka impregneringsmetoder som används i Sverige och vilka medel som används. Detta görs för att analysera vilken av dessa metoder som kan vara en lämplig ersättning för kreosotimpregnering. En samlad bedömning av resultat och data från denna undersökning visade att Skellefteå Kraft AB kan fortsatt använda sig utav kopparsaltimpregnerade stolpar (Wolmanit CX-8 eller Wolmanit CX-8N) ifall kreosot fasas ut. Dessutom föreslås tryckimpregneringsmetoderna (fullcell eller Lowry metoden) behållas. Skellefteå Kraft AB har redan ett inköpsavtal med Rundvirke Poles AB angående beställning av nya stolpar. Rundvirke Poles AB tillverkar kopparsaltstolpar i alla dimensioner och storlekar och för Skellefteå Krafts del kan det tills vidare vara lämpligt att inköpsavtalet fortsätter gälla. Företag som Skellefteå Kraft bör dock vara öppna för nya och bättre medel och träskyddsmetoder som kan ge bättre prestanda och en mer fördelaktig livscykel. Ett sådant kan vara RVP Repellent som Poles AB utvecklar men här bör fördjupade tester, livscykelanalyser och kontroller utföras på träskyddsmedlet och produkten.
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Awaijan, Sara, i Elin Karlsson. "Upplevelsestrategi vid kundinteraktioner : En jämförandestudie om kundupplevelsen i kundservice på bank och elhandelsbolag". Thesis, Mälardalens högskola, Industriell ekonomi och organisation, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-49126.
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The rapid development of today’s society is accelerated with digitalization and the customers have more possibilities to compare businesses with each-other than before. The focus on Customer Experience have increased in popularity during the last decade and an increasing number of companies have begun to consider the importance of their customers, the society, and their personnel. This study explores the customer experience in two companies in different industries and how it can be expanded to increase competitiveness and the emotional value towards the customers. An energy company and a bank are compared regarding their operations surrounding customer focus and employee commitment to identify challenges and possibilities in combination to increased digitalization. This study investigates how Customer Experience Management can be introduced, which is a corporate strategy to lift the emotional aspects of a company in order to increase the connection to its customers. The study compares two companies through qualitative interviews and a quantitative employee survey to answer three research questions; (1) the current way in which the companies operate, (2) possibilities to develop through Customer Experience Management, and finally (3) how digital tools can be introduced in order to elevate the customer experience. The analysis combines the empirical findings with literature and theories to enable development for businesses who aim to increase their customer focus and customer experience concerning customer service and the organization. The findings of this study show that the companies have opportunities to progress in areas such as strategic focus, organizational culture and the potential to implement digital tools in order to increase the customer experience. Important factors which are considered drivers in the customer experience are ways to increase the customer satisfaction and loyalty, the commitment and motivation of the employees, as well as expressed strategies to saturate the organization. An increased focus on emotional value creation is considered crucial for companies to differentiate and increasing their competitiveness.I dagens samhälle går utvecklingen snabbt med hjälp av digitaliseringens framfart och kunder har mer och mer möjligheter till att jämföra företag mellan varandra. Att fokusera på kundupplevelser har ökat i popularitet under de senaste åren där fler och fler företag inser vikten av att bry sig om sina kunder, samhället och sin personal. Denna studie undersöker kundupplevelsen på två företag och vad som kan göras för att utveckla den. Ett energibolag och en bank jämförs i deras arbetssätt kring kundfokus och medarbetarengagemang inom kundservice för att identifiera utmaningar och möjligheter i samband med ökad digitalisering. Studien undersöker hur man kan introducera Customer Experience Management, vilket är en ledningsstrategi som fokuserar på att lyfta företagens emotionella delar för att skapa starkare band till kunderna och öka konkurrenskraften. Studien jämför två företag genom djupintervjuer och en medarbetarenkät för att svara på tre forskningsfrågor som handlar om; (1) det nuvarande arbetssättet, (2) utvecklingsmöjligheter från ett perspektiv kring Customer Experience Management, och slutligen (3) hur digitala verktyg kan introduceras för att höja kundupplevelsen. Analysen kombinerar de empiriska fynden med litteratur och teorier för att ge möjligheter till utveckling för företag som vill utveckla sitt kundfokus och kundupplevelse inom kundservice och organisationen i sig. Slutsatserna visar att företagen har utmaningar inom områden så som strategiskt fokus, organisationskultur och potential för digitala verktyg som kan användas för att höja kundupplevelsen i företagen. Viktiga parametrar som identifieras som drivande för att öka kundupplevelsen är bland annat verktyg för att öka kundnöjdhet och lojalitet, medarbetarnas engagemang och motivation samt uttalade strategiska val som genomsyrar hela organisationen. Att fokusera på emotionellt värdeskapande i företagen ses som en grundläggande utvecklingsmöjlighet för företag som vill differentiera sig och öka konkurrenskraften.
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Vöckl, Josef Philipp [Verfasser], i Charlotte [Akademischer Betreuer] Wagner. "Untersuchungen zur Bedeutung von Connexin 40 für die Kontrolle des Reninsystems und die Lokalisation reninbildender Zellen - Tamoxifen-induzierte Cx 40 Deletion in der ausdifferenzierten Mausniere / Josef Philipp Vöckl ; Betreuer: Charlotte Wagner". Regensburg : Universitätsbibliothek Regensburg, 2016. http://d-nb.info/1117219380/34.
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Rjosk, Camilla. "Zuwanderungsbezogene Klassenzusammensetzung". Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17400.
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In der Dissertation wurden Effekte der zuwanderungsbezogenen Klassenzusammensetzung auf verschiedene Leistungsmaße und psychosoziale Schülermerkmale im Rahmen von drei Zeitschriftenbeiträgen untersucht. In Teilstudie eins wurden Effekte der sozialen und zuwanderungsbezogenen Zusammensetzung auf das Leseverständnis im Verlauf der neunten Klasse und deren Vermittlung durch Merkmale der Unterrichtsqualität analysiert. Der Klassenanteil von Heranwachsenden mit Zuwanderungshintergrund war unter Kontrolle des mittleren sozioökonomischen Status nicht mit der Leseleistung assoziiert. Es zeigten sich Hinweise einer partiellen Vermittlung des Effekts sozialer Zusammensetzung durch das Ausmaß herausfordernden Sprachunterrichts. Teilstudie zwei beschäftigte sich mit Effekten der Zusammensetzung auf die Lernmotivation im Verlauf der neunten Klasse und deren Vermittlung durch das Ausmaß schülerorientierten Unterrichtsklimas. Heranwachsende mit Zuwanderungshintergrund berichteten höhere Motivation, wenn sie Klassen mit einem höheren Anteil von Heranwachsenden mit Zuwanderungshintergrund besuchten. Es zeigten sich keine vermittelten Effekte durch Merkmale des Unterrichtsklimas. In Teilstudie drei wurden der Anteil von Kindern mit Zuwanderungshintergrund und Maße zuwanderungsbezogener Heterogenität in ihrer Assoziation mit Mathematik- und Leseleistung sowie dem Verbundenheitsgefühl mit Peers von Kindern der vierten Klasse verglichen. Es bestanden stärkere negative Effekte des Klassenanteils im Vergleich zu Heterogenitätsmaßen. Bei simultaner Berücksichtigung von Klassenanteil und Heterogenitätsmaßen waren Heterogenitätseffekte größtenteils nicht mehr signifikant. Es zeigten sich jedoch leicht positive Heterogenitätseffekte auf die Mathematikleistung. Es bestanden keine Effektunterschiede zwischen Heterogenitätsmaßen. Die Befunde verweisen auf die Bedeutung der Schulklasse für die akademische Entwicklung sowie für die Erklärung zuwanderungsbezogener Disparitäten im Bildungssystem.The thesis at hand explored effects of the language-related and ethnic makeup of classrooms on several achievement outcomes as well as psychosocial outcomes in three research articles. The first article investigated effects of socioeconomic and language minority classroom composition on ninth graders’ reading achievement across two measurement points and explored the mediating role of instructional quality. The proportion of minority students had no effect on achievement after controlling for the socioeconomic composition. The results suggest that the effect of the socioeconomic composition on achievement may be mediated partially by the teacher’s focus on language during instruction. The second article focused on effects of the proportion of language minority students on the development of ninth graders’ motivation and the mediating role of a student-oriented climate. The analyses revealed that minority students were increasingly motivated in classrooms with a higher proportion of minority students. The compositional effect was not mediated by the instructional climate. The third article explored various measures of the ethnic makeup of classrooms and their relationship with student outcomes. The proportion of minority students and measures of diversity were compared in their prediction of fourth graders’ achievement in math and reading as well as the feeling of belonging with one’s peers. The proportion of minority students showed stronger negative effects on student outcomes than the diversity measures. Including diversity measures and the proportion of minority students, the diversity effects mostly lost their significance. However, students showed slightly higher levels of math achievement in more diverse classrooms. The various measures of diversity led to similar results. The findings add to the evidence indicating that the classroom learning environment affects students’ academic development and contributes to ethnic disparities in the education system.
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Lidén, Andreas. "Hur kan telekomkunders användning av själv-serviceteknologi öka? : En kvalitativ studie". Thesis, Högskolan i Skövde, Institutionen för informationsteknologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-15826.
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Syftet med studien har varit att undersöka hur telekomkunder användning av själv-serviceteknologi (SST) kan öka. Relevant litteratur som SST, teknologisk acceptans, user experience (UX), customer experience (CX) och servicedesign (SD) har identifierats och förankrat studien vetenskapligt. Baserat på syftet och den teoretiska grunden har en designstrategi skapats för att undersöka detta på ett relevant sätt på ett telekomföretag i Sverige. Studien har utgått från en formativ utvärdering där expertanvändares upplevelser av telekomkunder, kundservice och själv-serviceteknologi har studerats, för att kunna identifiera möjliga problem och förbättringsområden. Semi-strukturerade djupintervjuer har använts som datainsamlingsmetoden på grund av de förutsättningar som fanns för studien. Detta har i kombination med analysstrategierna har medverkat till identifieringen av kontextuella fynd som kan öka användning av SST för telekomföretagets kunder. Några av dessa fynd är att SST behöver vara standardiserad inom telekombranschen och att telekomföretaget kan öka användandet genom att informera sina kunder mer om möjligheterna med SST. I Studien har också faktorer som tyder på ett samband mellan områdena service, SST och telekomkunder identifierats, detta kan öka förståelsen för hur SST i denna kontext bör utvecklas och designas framöver.
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Clark, Jessica Celeste. "Automated Identification of Adverbial Clauses in Child Language Samples". Diss., CLICK HERE for online access, 2009. http://contentdm.lib.byu.edu/ETD/image/etd2803.pdf.
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Barriault, Patrick. "Développement d'une pédale dynamométrique pour vélo". Mémoire, Université de Sherbrooke, 2008. http://savoirs.usherbrooke.ca/handle/11143/1444.
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Ce mémoire de maîtrise a été effectué à l'Université de Sherbrooke pour VélUS, le groupe de R&D sur le vélo. Il présente en détails le cheminement suivi pour la réalisation d'une pédale dynamométrique interchangeable et compacte pour vélo, de la problématique jusqu'à sa mise en service. La pédale dynamométrique est compatible avec la plupart des pédaliers de vélo et avec les chaussures de pédales de piste Shimano PD-6400 et de route Look CX-7. Elle mesure in situ les forces de locomotion développées par le cycliste sur elle-même et aussi sa propre position angulaire par rapport au pédalier. Le mémoire illustre d'abord le concept mécanique permettant d'effectuer les mesures: un corps d'épreuve instrumenté de jauges extensométriques et d'un encodeur optique. Il s'attarde ensuite à la conception du capteur, qui consiste à dimensionner le corps d'épreuve pour satisfaire toutes les exigences: le positionnement du pied, la résistance mécanique, la sensibilité, la masse et l'encombrement; dans ce chapitre, on développe une méthode de travail pour assurer un bon fonctionnement du capteur et pour maximiser sa sensibilité. Par la suite, le mémoire présente l'instrumentation, l'étalonnage ainsi que des mesures effectuées par la pédale dynamométrique.
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Jansen, Malte. "Akademische Selbstkonzepte in den naturwissenschaftlichen Fächern". Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17105.
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Ziel des Dissertationsprojekts war eine differenzierte Betrachtung des akademischen Selbstkonzepts in den naturwissenschaftlichen Fächern. Unter anderen wurden die Abgrenzung des akademischen Selbstkonzepts von Selbstwirksamkeitserwartungen, seine dimensionale Struktur, Geschlechtsunterschiede sowie seine Beeinflussung durch die Konzeption des Naturwissenschaftsunterrichts und durch dimensionale Vergleiche untersucht. Im Mittelpunkt der ersten Teilstudie stand die Frage nach der empirischen Trennbarkeit von akademischem Selbstkonzept und Selbstwirksamkeitserwartung in den Naturwissenschaften. Es konnte gezeigt werden, dass die beiden Konstrukte messtheoretisch klar abgrenzbar sind und differentielle Zusammenhänge zu anderen Konstrukten aufweisen: Das Selbstkonzept wurde stärker durch soziale Vergleiche, Selbstwirksamkeitserwartungen stärker durch Unterrichtscharakteristika beeinflusst. In der zweiten Teilstudie wurde die fachspezifische Ausdifferenzierung naturwissenschaftlicher Selbstkonzepte untersucht. Es konnte gezeigt werden, dass Schüler zwischen den Selbstkonzeptfacetten in Biologie, Chemie und Physik unterscheiden und diese drei Facetten differentielle Zusammenhänge zu Leistungsmaßen und zum Geschlecht aufweisen. Die dritte Teilstudie beschäftigte sich mit interdisziplinärem Naturwissenschaftsunterricht als Einflussfaktor auf die Selbstkonzeptstruktur. Dabei konnte gezeigt werden, dass Schüler, die interdisziplinär beschult werden, deutlich höhere Zusammenhänge zwischen den Selbstkonzeptfacetten in Biologie, Chemie und Physik aufweisen als Schüler, die getrennt in den drei Fächern unterrichtet werden. In der vierten Teilstudie wurde der Einfluss dimensionaler Leistungsvergleiche auf naturwissenschaftliche Selbstkonzepte sowie Mathematik und Deutsch untersucht. Es zeigten sich Kontrasteffekte zwischen Mathematik, Physik und Chemie auf der einen und Deutsch auf der anderen Seite. Die Befunde haben Implikationen für die Theorie dimensionaler Vergleiche.In this dissertation project, academic self-concept in the science subjects is scrutinized. Amongst others, its separability from self-efficacy, its dimensionality, and gender differences were examined. The dissertation includes four research articles. All are based on data from large-scale assessment studies. In the first research article, we examined whether academic self-concept and self-efficacy in the science subjects can be distinguished empirically. We found a moderate positive correlation between self-concept and self-efficacy in science, advocating distinguishable constructs. Furthermore, science self-concept was better predicted by the average peer achievement, whereas science self-efficacy was more strongly affected by inquiry-based learning opportunities. The second research article focused on the internal structure of academic self-concept in the sciences. It could be shown that students differentiate between their abilities in biology, chemistry and physics and that the subject-specific self-concept facets are differentially related to achievement and gender. For example, stereotypical gender differences in favor of boys were found for chemistry and physics. The effect of interdisciplinary science teaching on the structure of academic self-concept in the sciences was examined in the third research article. Students who were taught science as an interdisciplinary subject showed substantially higher relations between the self-concept facets in biology, chemistry, and physics than students who were taught these subjects separately. In the fourth research article, the effects of dimensional comparisons on academic self-concepts in the sciences as well as mathematics and German were scrutinized. We found contrast effects between the German and math, physics, and chemistry as well as assimilation effects between math, physics, and chemistry. The results further advance dimensional comparison theory.
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Sachse, Karoline A. "Trendschätzung in Large-Scale Assessments bei differenziellem Itemfunktionieren". Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/21131.
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Differenzielles Itemfunktionieren bedeutet für die Trendschätzung durch Linking in querschnittlich angelegten Large-Scale Assessments eine Voraussetzungsverletzung. Solche Voraussetzungsverletzungen können sich negativ auf die Eigenschaften von Trendschätzern auswirken, woraus sich Einschränkungen für die Interpretierbarkeit der Trendschätzung ergeben können. Die vorliegende Arbeit umfasst, eingebettet in einen Rahmungstext, drei Einzelbeiträge, die sich mit der Prüfung der Auswirkung differenziellen Itemfunktionierens unterschiedlicher Provenienz auseinandersetzen.
Im ersten Einzelbeitrag wird die Interaktion von Linkingdesigns und Linkingmethoden mit zwischen Ländern und über die Zeit unsystematisch unterschiedlich funktionierenden Items untersucht. Dabei zeigte sich, dass die Wahl des Designs von großer Bedeutung sein kann, während der Performanzunterschied zwischen gängigen Linkingmethoden marginal war. Darüber hinaus führte der häufig praktizierte Ausschluss von differenziell funktionierenden Items zu einem Effizienzverlust.
Im zweiten Einzelbeitrag wird die Unsicherheit der Trendschätzung, die entsteht, wenn Items zwischen Ländern und über die Zeit unsystematisch unterschiedlich funktionieren, quantifiziert und in die Berechnung der zugehörigen Standardfehler integriert.
Im dritten Einzelbeitrag wird betrachtet, wie differenziellem Itemfunktionieren begegnet werden kann, das durch fehlende Werte und wechselnde Ausfallmechanismen zustande kommt. Wurden die fehlenden Werte inadäquat behandelt, verloren die Trendschätzer ihre Erwartungstreue und Konsistenz sowie an Effizienz.
In der Summe wird in der vorliegenden Arbeit identifiziert und hervorgehoben, dass es in den untersuchten Bedingungen je nach Art des differenziellen Itemfunktionierens effektive Möglichkeiten des Umgangs mit diesem gibt, die potenziellen Einschränkungen bei der validen Interpretation der Trendschätzung zumindest teilweise entgegenwirken können.Differential item functioning signifies a violation of the prerequisites required for trend estimation, which involves the linking of cross-sectional large-scale assessments. Such violations can negatively affect the properties of the trend estimators. Hence, the interpretability of trend estimates will be limited under such circumstances. Embedded within an overarching framework, three individual contributions that examine and deal with the effects of differential item functioning from different origins are presented in the current dissertation. The first article examines the interactions of linking designs and linking methods with items that show unsystematic and differential functioning between countries and across time. It showed that the choice of the design can be of great importance, whereas the difference in performance between common linking methods was marginal. In addition, the exclusion of differentially functioning items, an approach that is frequently used in practice, led to a loss of efficiency. In the second contribution, the uncertainty for the trend estimation resulting from items that show unsystematic and differential functioning between countries and across time is quantified and incorporated into the calculation of the trends' standard errors. The third article focuses on differential item functioning that is induced by missing values and nonresponse mechanisms that change over time. When the missing values were treated inappropriately, the trend estimators lost their unbiasedness, their consistency, and their efficiency. In sum, this dissertation identifies and emphasizes the ideas that, depending on the type of differential item functioning, there are effective ways to deal with it under the investigated conditions, and these can at least partially counteract potential limitations so that the trend estimates can still be interpreted validly.
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Ellis, Mark Charles. "Microwave studies of the internal rotors Xâ†3CNOâ†2 (X=Cl,F) and Fâ†3SiN(CHâ†3)â†2 : rotational spectra and zero-point average structures of CFâ†3C#ident to#CX (X=F,H), CHâ†3C#ident to#CCl, CFâ†3CN and the asymmetric tops HNOâ†3 and HONO". Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385663.
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Gordana, Lalić-Krstin. "Morfemizacija krnjih leksičkih osnova u engleskom jeziku:leksikološki i leksikografski aspekti". Phd thesis, Univerzitet u Novom Sadu, Filozofski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=100978&source=NDLTD&language=en.
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Ova disertacija se bavi procesom morfemizacije krnjih osnova koje su nastaleod leksičkihslivenica. Rekurzivinimslivanjem s različitim inicijalnim elementima,ove osnove se konsoliduju u svom skraćenomobliku ili oblicima, što za rezultat imaseparaciju novih tvorbenih jedinica. Najbitnijiciljevi istraživanja su sledeći: da se utvrditeorijski i terminološki status ovih elementa iodrede kriterijumi za njihovo članstvo u ovojkategoriji; da se na osnovu tih kriterijumanapravi popis morfemizovanih elemenata uzrazvoj metodologije potrebne za njihovuekscerpciju; da se sačini spisak leksema ukojima se javljaju; da se ustanove formalnevarijacije i njihova relativna učestalost kao itipovi i oblici inicijalnih elementa sa kojimase kombinuju, što bi za rezultat imaloformulisanje prototipskog tvorbenog modela;da istraži značenje ovih elemenata, eventualnirazvoj novih semema i smisaonih odnosa; dadâ pregled njihove zastupljenosti upostojećim rečnicima; da predloži modelnjihove leksikografske obrada i da se naosnovu tog predloga sačini rečnik kakomorfemizovanih krnjih osnova, tako i reči ukojima se javljaju.This dissertation investigates the process ofAB morphemization of truncated bases whichhave originated from lexical blends. Throughtheir recurrent blending with various initialelements, they become consolidated in theirtruncated form or forms, resulting in thesecretion of new word-formational units. Themost important goals of the research are thefollowing: to determine the theoretical andterminological status of these elements andestablish the criteria for categorymembership; to compile a list ofmorphemized elements based on thesecriteria by developing the methodology fortheir extraction; to compile a list of lexemescontaining these newly morphemizedelements; to determine formal variations andtheir relative frequency as well as the typesand forms of initial elements with which theycombine, resulting in theformulation of theprototypical word-formation pattern; toinvestigate the meaning of these elements andthe development of new senses and senserelations; to give an overview of theirrepresentation in existing dictionaries; topropose a model for their lexicographictreatment and to apply that model in thecompilation of a specialized dictionary ofmorphemized truncated bases and words inwhich they appear.
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Schantl, Helmut. "Schule als "triadischer Raum"". Doctoral thesis, Humboldt-Universität zu Berlin, Philosophische Fakultät IV, 2011. http://dx.doi.org/10.18452/16407.
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Ausgehend von der These, dass das Verhalten „schwieriger“ Kinder eine Folge kulturell-gesellschaftlicher Entwicklungen ist, die sich nachteilig auf den innerpsychischen Prozess der Triangulierung auswirken und auf die eine von zweckrationalen Organisationsstrukturen, von institutionsspezifischen Kommunikations- und Handlungsformen und von einem veränderten professionellen Selbstverständnis einzelner Lehrer dominierte Schule bislang keine befriedigenden Antworten gegeben hat, wird nach dem Potenzial der Psychoanalyse hinsichtlich der Möglichkeit gefragt, Pädagogen und Pädagoginnen bei der Konstituierung von Schule als ‚triadischer Raum’ im Sinne eines dyadisch geprägten und triadisch strukturierten, die kindliche Entwicklung fördernden psychosozialen Erfahrungsraums zu unterstützen. Am psychoanalytischen Theorem der Triangularität orientiert wendet sich die Erörterung zunächst drei von der Psychoanalyse beeinflussten sozialisationstheoretischen Konzepten unterschiedlicher Provenienz zu. Dieses methodische Vorgehen erweist sich jedoch im Kontext der zentralen Zielsetzung, ein umfassendes pädagogisches Konzept zur Stärkung kindlicher triangulärer psychischer Strukturen zu skizzieren, nur bedingt als hilfreich. Die anschließende Diskussion der Problem- und Fragestellung auf der Folie einer ‚kulturtheoretisch orientierten’ Psychoanalyse, die einem eigenständigen wissenschaftstheoretischen Selbstverständnis und Erkenntnisprozess folgend unbewusste individuelle und überindividuelle, kulturspezifische Subjektivitätsmomente wie auch biologische Determinanten seelischen Erlebens und Verhaltens berücksichtigt, führt zur Formulierung dreier Dimensionen des dialektischen Prinzips der Psychoanalyse, die sich im Bemühen um die Gestaltung triangulär organisierter Verständigungsprozesse als hilfreich erweisen können.Based on the theory that the behavior of „difficult“ children is a result of a socio-cultural evolution that has adversely affected the inner-psychological process of triangulation and, based on the school of thought of purposive-rational organizational structures and that of institution-specific forms of communication and action, along with the altered professional self-understanding of individual teachers – noneof which have yet to offer any satisfactory answers – the question arises in accordance with the potential of psychoanalysis concerning the possibilities for educators in the constitution of a school as a ‚triadic space’, dyadically characterized and triadically structured to support the constructive psycho-social realm of experience in childhood development. Oriented on the psychoanalytical theorem of triangularity, the analysis initially adresses the varied provenience of three concepts influencing the socializationtheoretically and psychoanalytically. In the context of a central target, this methodic approach proves to be only slightly helpful when outlining a comprehensive pedagogical concept to reinforce childhood triangular psychological structures. The subsequent discussion of the problems addressed on the slides of ‚cultural-theorist-oriented’ psychoanalysis, following an independent epistemological self-understanding and cognitive process, taking unconscious individual and supraindividualculture-specific moments of subjectivity as well as biological determinants of emotional experience and behavior into consideration, leads to the formulation of tree dimensions of the dialectic principle of psychoanalysis that might prove to be helpful when attempting to configure triangularly organized processes of understanding.
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Stahnke, Rebekka. "Teachers’ Situation-Specific Skills With a Particular Focus on Classroom Management". Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/23024.
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Situations-spezifische Fertigkeiten sind ein wichtiger Teil von Lehrerexpertise und insbesondere im Bereich des Klassenmanagements bedeutsam. Vor dem Hintergrund der Kompetenz- und Expertiseforschung synthetisiert die vorliegende Dissertation bisherige Befunde systematisch und untersucht, wie sich Novizen- und Expertenlehrpersonen in ihren Fertigkeiten hinsichtlich des Klassenmanagements unterscheiden. Studie 1 fasst den Forschungsstand in einem systematischen Review von 60 empirischen Studien zusammen und arbeitet Erkenntnisse zu Fertigkeiten und ihrer Förderung sowie zum konzeptuellen Rahmen der Studien heraus. Für Studie 2 und Studie 3 werden die Fertigkeiten von 20 Noviz*innen und 20 Expert*innen mit Hilfe von Videoausschnitten untersucht, die für das Klassenmanagement relevante Ereignisse zeigen. Studie 2 erforscht mit Hilfe von Eye-Tracking-Methoden insbesondere die Fertigkeit der Wahrnehmung sowie formatspezifische Expertiseeffekte. Es fand sich bei Expert*innen ein Fokus auf Schüler*innen, während Noviz*innen vor allem beim Partnerarbeitsformat weniger ausgeprägte Fertigkeiten zeigten. Studie 3 untersucht anhand von retrospektiven verbalen Analysen Expertiseeffekte hinsichtlich des Wahrnehmens, Interpretierens und Entscheidens. Expertise war erneut durch einen Fokus auf Schüler*innen gekennzeichnet. Zudem boten Expert*innen mehr Handlungsmöglichkeiten an als Noviz*innen. Zusammenfassend lässt sich feststellen, dass Expert*innen vor allem hinsichtlich des Entscheidens überlegen sind. Weiterhin deuten die Ergebnisse darauf hin, dass offenere Unterrichtsformate für Noviz*innen besonders herausfordernd sind. Die Bedeutung der Ergebnisse wird hinsichtlich der allgemeinen Expertise- und Kompetenzforschung sowie der Klassenmanagementforschung diskutiert. Die Studien zeigen theoretische Inkohärenz hinsichtlich des Konstrukts situations-spezifischer Fertigkeiten auf, sowie eine starke Fokussierung bisheriger Forschung auf Störungen in Frontalunterrichtsszenen.Situation-specific skills are an important part of teacher expertise and are particularly relevant in the area of classroom management. Against the background of general and classroom management-specific teacher competence and expertise research, this dissertation systematically synthesized previous findings and also investigated how novice and expert teachers differ in their skills with regard to classroom management. Study 1 summarized the state of research in a systematic review of 60 empirical studies, thereby identifying insights into teachers’ skills and their facilitation, as well as the conceptual frameworks of the studies. For Study 2 and Study 3, the skills of 20 novice and 20 expert teachers were examined using video clips that show events relevant to classroom management. Study 2 investigated format-specific expertise effects and, in particular, the skill of perception by using eye tracking methods. Experts were found to focus on students and their learning, while novices showed less pronounced skills, especially in the partner work format. Using teachers’ retrospective verbal analyses of classroom management events, Study 3 examined expertise effects with respect to teachers’ perception, interpretation and decision-making. Again, expertise was characterized by a focus on students. In addition, experts proposed more alternative courses of action than novices. In summary, it can be concluded that experts are superior to novices especially with regard to the skill of decision-making. Furthermore, the results indicate that more open formats of instruction are particularly challenging for novices. The relevance of the results is discussed with regard to general expertise and competence research as well as classroom management research. The studies point to theoretical ambiguities regarding the construct of situation-specific skills, as well as an overemphasis of previous research on behavioral management in whole-group instruction settings.
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Leisterer, Sascha. "Affekte und Emotionen im Sportunterricht – Pädagogisch-psychologische Unterrichtsforschung aus der Schülerinnen-Schüler-Perspektive". Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22878.
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In dieser Dissertation wurde zur Untersuchung von Affekten und Emotionen als zentrales Phänomen im Sportunterricht ein Modell entwickelt, das das affektiv-emotionale Erleben im Sportunterricht aus Schülerinnen-Schüler-Perspektive als eigenständiges Phänomen betrachtet und in Bezug zu seinen Auslösern, Unterrichtsmaßnahmen und Konsequenzen setzt. Zur Beschreibung des affektiv-emotionalen Erlebens wurden Auslöser von Affekten und Emotionen in einer qualitativen Interviewstudie exploriert: Attraktivität der Aufgabe, Zugehörigkeit, Kompetenz und Autonomie erscheinen als entscheidende Auslöser des affektiv-emotionalen Erlebens aus Sicht der Schülerschaft. Daran anknüpfend wurden Kompetenz und Zugehörigkeit experimentell untersucht, um die Wirkung dieser Auslöser auf das affektiv-emotionale Erleben zu überprüfen. Eine positive bzw. negative Kompetenzbedingung führt zu einem positiven bzw. negativen Affekt und soziale Interaktion (Zugehörigkeitsbedingung) führt zu einem positiven Affekt bei den Schülerinnen und Schülern. Weiterführend wurden in einer systematischen Review Arbeit Unterrichtsmaßnahmen untersucht, die das affektiv-emotionale Erleben der Schülerinnen und Schüler im Sportunterricht effektiv beeinflussen können, indem sie die explorierten Auslöser anwenden. Dabei kann gezeigt werden: Autonomieunterstützende Unterrichtsmaßnahmen, die mit den identifizierten Auslösern zusammenhängen, können zu einem positiven affektiv-emotionalen Erleben bei den Schülerinnen und Schülern führen. Die identifizierten Auslöser des affektiv-emotionalen Erlebens und die effektiven Unterrichtsmaßnahmen werden in dieser Dissertation in ein heuristisches Modell zur Erklärung des affektiv-emotionalen Erlebens von Schülerinnen und Schülern im Sportunterricht integriert und hinsichtlich zukünftiger Forschungsansätze inhaltlich und methodisch diskutiert. Diese Dissertation schließt mit zukünftigen Forschungsfragen und praktischen Implikationen für die Bildungslandschaft.This doctoral thesis focusses on affective and emotional states of students in the context of physical education (PE). Affects and emotions represent the theoretical framework. In order to investigate affects and emotions as a central phenomenon in PE, a model was developed that declares the affective and emotional states of students in PE to an independent phenomenon and relates this to its triggers, teaching styles and consequences. A qualitative interview study explored triggers of affects and emotions to describe the affective-emotional states: attractiveness of the task, belonging, competence, and autonomy appear to be decisive triggers of the affective-emotional states from the students' perspective. Based on this, competence and belonging were experimentally examined in order to successfully check the effect of these triggers on the affective and emotional states. A positive or negative trigger of competence influences students’ positive or negative affect and social interaction (belonging) influences students’ positive affect. In addition, teaching styles using the explored triggers were examined in a systematic review due to their influencing effects on the affective-emotional states of students in PE. It can be shown that autonomy-supportive teaching styles, which are related to the identified triggers, can positively influence the affective and emotional states of students. The identified triggers of the affective-emotional states and possible teaching styles are integrated into a heuristic model of affective-emotional states from students’ perspectives in PE. Based on this heuristic model, the contribution of this thesis will be critically reflected for further analysis of affective-emotional perception in future studies. Finally, the presented research is linked to future research questions. Practical implications are addressed for PE classes, schools, teacher training and general educational policy.
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Reichow, Insa. "Students’ Affective-Motivational Research Dispositions". Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22673.
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In dieser Dissertation wurden drei zentrale Ziele mit einem Mixed-Methods-Ansatz verfolgt.
Ein erstes Ziel war es, ein umfassendes Modell affektiv-motivationaler Forschungsdispositionen für Studierende der Sozialwissenschaften zu entwerfen, da sich existierende Konzeptionen von Forschungskompetenz ausschließlich auf kognitive Leistungsdispositionen konzentrieren. Mithilfe von Experteninterviews und einem Expertenrating wurden neun affektiv-motivationale Forschungsdispositionen identifiziert, die notwendig sind, um die Anforderungen eines sozialwissenschaftlichen Forschungsprozesses zu meistern.
Ein zweites Ziel lag in der Entwicklung und Validierung von Testinstrumenten zur Erfassung der identifizierten affektiv-motivationalen Forschungsdispositionen. Basierend auf den Standards der psychologischen Testkonstruktion konnten Selbsteinschätzungsskalen für alle neun affektiv-motivationalen Forschungsdispositionen erarbeitet und Validierungsnachweise erbracht werden.
Diese Arbeiten bildeten die Grundlage für das Erreichen des dritten Ziels: Es sollte getestet werden, inwieweit die Teilnahme am Forschenden Lernen zu einer Entwicklung kognitiver und affektiv-motivationaler Forschungsdispositionen führt. Das Forschende Lernen ist ein didaktisches Format, bei dem Studierende eigenständig einen Forschungszyklus durchlaufen, um eine Forschungsfrage zu beantworten. Bis dato lagen zwar theoretische Postulate zur Wirksamkeit Forschenden Lernens in den Sozialwissenschaften vor, aber kaum empirische Befunde. Im Rahmen einer Prä-Post-Studie (N=952) in Veranstaltungen des Forschenden Lernens zeigte sich, dass Studierende sowohl positive als auch negative Entwicklungen verschiedener Forschungsdispositionen aufweisen. Als zentral erwies sich die Rolle der begleitenden Lehrperson.This dissertation addressed three central goals using a mixed-methods approach: The first goal was to develop a comprehensive model of affective-motivational research dispositions for students of the social sciences since existing models of research competence concentrate on cognitive dispositions. With the help of expert interviews and an expert rating, nine affective-motivational research dispositions were identified. The second goal was the development and validation of test instruments to assess the identified affective-motivational research dispositions. Based on the standards of psychological test construction, self-assessment scales were developed for all nine affective-motivational research dispositions and evidence for their validity was generated. These previous steps formed the basis for addressing the third goal: To test whether research-based learning is a suitable format to foster different cognitive and affective-motivational research dispositions in the social sciences. Research-based learning is a didactic format in which students complete a full research cycle to answer a research question. So far, there are many theoretical claims on the effectiveness of research-based learning in the social sciences but a lack of empirical evidence. In a pre-post study (N=952) in research-based learning courses, it was shown that students benefit from a favourable development of some of the research dispositions, whereas other dispositions decreased. The role of the facilitating instructor proved to be central.
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Bono, Jason S. "First Time Measurements of Polarization Observables for the Charged Cascade Hyperon in Photoproduction". FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1520.
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The parity violating weak decay of hyperons offers a valuable means of measuring their polarization, providing insight into the production of strange quarks and the matter they compose. Jefferson Lab’s CLAS collaboration has utilized this property of hyperons, publishing the most precise polarization measurements for the Λ and Σ in both photoproduction and electroproduction to date. In contrast, cascades, which contain two strange quarks, can only be produced through indirect processes and as a result, exhibit low cross sections thus remaining experimentally elusive.
At present, there are two aspects in cascade physics where progress has been minimal: characterizing their production mechanism, which lacks theoretical and experimental developments, and observation of the numerous excited cascade resonances that are required to exist by flavor SU(3)F symmetry. However, CLAS data were collected in 2008 with a luminosity of 68 pb−1 using a circularly polarized photon beam with energies up to 5.45 GeV, incident on a liquid hydrogen target. This dataset is, at present, the world’s largest for meson photoproduction in its energy range and provides a unique opportunity to study cascade physics with polarization measurements.
The current analysis explores hyperon production through the γp → K+K+Ξ− reaction by providing the first ever determination of spin observables P, Cx and Cz for the cascade. Three of our primary goals are to test the only cascade photoproduction model in existence, examine the underlying processes that give rise to hyperon polarization, and to stimulate future theoretical developments while providing constraints for their parameters. Our research is part of a broader program to understand the production of strange quarks and hadrons with strangeness. The remainder of this document discusses the motivation behind such research, the method of data collection, details of their analysis, and the significance of our results.
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Tu, Hsin-Chieh, i 杜欣潔. "Implementation of the IP Multimedia Subsystem Cx Interface". Thesis, 2003. http://ndltd.ncl.edu.tw/handle/79435590400688450262.
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碩士國立交通大學
資訊工程系
91
In recent years, the operators over the world all face the phase of transferring the second generation mobile communication system (2G) to the third generation (3G). However, there are few ones to really provide the services of the 3G mobile system. So far, only the NTT DoCoMo in Japan has published the 3G services. Therefore, before the technology of developing the 3G communication system becomes mature, it is still such an issue that we are concerned about to improve the technique for deploying the 3G system. In this thesis, based on the requirements and functionalities defined by the 3GPP, we designed an overall architecture for implementing the IP Multimedia Subsystem (IMS) Cx Interface. The Cx Interface provides a reliable bridge for the HSS and the CSCF in the IMS. The HSS and the CSCF could process the authentication and the authorization for the IMS users, and exchange the information needed while providing the services.The Cx Interface presented in this thesis could be used on the testing platform of the 3G system for the academic research. It also provides a thorough solution for the Cx Interface, for the operators who are interested in deploying the 3G networks.
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陳思寰. "Mechanical properties and microstructures of the (CrNbTaTiZr)Cx coatings". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/38193542443807910804.
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Liu, Yu-Wen, i 劉育妏. "Role of CX in increasing the antibacterial photodynamic inactivation". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/88471357671310077126.
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碩士國立臺灣大學
微生物與生化學研究所
97
Previously, we have found that coincubation of compound X (CX) with Hematoprophyrin can enhance the photodynamic inactivation (PDI) effect against bacteria. In this study, we further investigate whether CX can also enhance the PDI efficacy mediated by other photosensitizers (PSs) in Gram positive as well as in Gram negative bacterium Staphylococcus aureus. We found that CX can also synergistically enhance the PDI antimicrobial effect mediated by Chlorin e6, Rose Bengal, Methylene Blue, and Toluidine Blue O with different charges and polarities. These results show the possibility of CX working in different PSs mediated PDI. Furthermore, we address the uptake and PDI effect by the hydrophobic PS, Chlorine 6 (Ce6) in its free form or encapsulated by micelle (PF127-Ce6) for different incubation times and concentrations in S. aureus. We found that the uptakes of free form Ce6 and PF127-Ce6 reached the maximum after 10 minutes incubation. Besides, the uptake and PDI efficacy is proportional to the concentration of Ce6. We found that if the PDI can exert more than 2 logs in bacterial killing, 0.025% CX can synergistically result in complete killing. Meanwhile, CX can also enhance the PDI effect in Gram negative bacteria such as Pseudomonas aeruginosa and Methicillin-resistant S. aureus (MRSA).
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Amaral, Ricardo Miguel Palos Peres do. "Master thesis: customer experience return on investment (Cx ROI)". Master's thesis, 2019. http://hdl.handle.net/10362/73211.
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Nowadays, Customer Experience is in the center of every company’s strategy. However, executives struggle to accurately compute Customer-based investments’ ROI using currently available tools. Based on recent KPMG studies, this research aims to determine, statistically, which are the main drivers of a successful CX delivered by a given firm, measured through the NPS. Using real evidence from a Portuguese Bank and Alteryx software, a practical case was performed to validate the robustness of the research methodology. Final conclusions advocate that different customers’ behavior lead to different CX drivers, suggesting the importance of Personas’ Analysis to efficiently reach a better CX.
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Brodmann, Tobias. ""Eine vergleichende Genexpressionsanalyse von Gap- Junction- Strukturproteinen in oralen Plattenepithelkarzinomen und gesunder Schleimhaut"". Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-0006-B31D-1.
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Lin, Chi-Wei, i 林季薇. "Study on the Microstructure and Properties of Multi-element (CrNbSiTiZr)Cx Coatings". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/12763328048008910437.
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Stringer, Megan. "The identification of increased Dyrk1a protein levels in Ts65Dn mice guides the targeted administration of the novel Dyrk1a inhibitor CX-4945". Thesis, 2018. https://doi.org/10.7912/C2Q94K.
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Indiana University-Purdue University Indianapolis (IUPUI)Down syndrome (DS) is caused by three copies of human chromosome 21 (Hsa21) and results in phenotypes including intellectual disability. Ts65Dn mice, the most extensively studied DS model, have three copies of ~50% of the genes on Hsa21 and display many phenotypes associated with DS, including cognitive deficits. DYRK1A is a dosage-sensitive gene found in three copies in humans with Trisomy 21 and in Ts65Dn mice and is involved in CNS development. Overexpression of DYRK1A is hypothesized to cause many of the cognitive and developmental deficits observed in DS and has been touted as a target for drug development in DS. Definitive evidence that excessive expression/activity of Dyrk1a directly contributes to specific phenotypes in DS mouse models is limited, and there is no direct evidence that verified pharmacological inhibition of Dyrk1a in vivo causes enduring improvement in DS cognitive phenotypes. In part, this reflects the remarkably limited knowledge of the temporal regulation of Dyrk1a expression and activity in different brain regions across development in DS mouse models. To establish the therapeutic potential of Dyrk1a inhibitors, the first aim of this study was to determine when and in what brain regions excessive Dyrk1a is evident and to identify developmental periods when elevated expression of Dyrk1a may be contributing to enduring aberrant functional development. This aim provided systematic quantification of Dyrk1a protein level at key postnatal (P) ages (P12, P15, P18, P24 P30, P42) in Ts65Dn mice, at ages of translational relevance to clinical applications in humans (birth, early adolescence, late adolescence, young adult). Western blot analysis showed that significant elevation of Dyrk1a with the largest effect sizes occurred in trisomic mice on P15. The second aim of this study was to test whether treating Ts65Dn with a novel Dyrk1a inhibitor (CX-4945) during the time of Dyrk1a elevation would rescue the behavioral and structural abnormalities observed. From P14-P18, Ts65Dn and euploid mice were treated with 75mg/kg CX-4945 or DMSO (vehicle) and tested on a homing task and locomotor activity in a novel arena on P17-P18, counterbalanced for order. At the cessation of treatment, hippocampal cell proliferation was assessed. While there was a lack of statistically significant improvements with CX-4945 treatment, there were modest effect sizes. In addition, several of the behavioral studies were significantly underpowered, making it difficult to conclusively ascertain the efficacy of CX-4945 on specific phenotypes. Nevertheless, this study demonstrates that Dyrk1a is dynamically expressed across development in mice, and suggests that consideration of the spatial and temporal expression of Dyrk1a may well be critical in the development of therapeutics for DS.
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Jiang, Yaw-Jang, i 江耀章. "TAB/Cx Application in the operating efficiency improvement of ice storage system in office building". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/pj9x3t.
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碩士國立臺北科技大學
能源與冷凍空調工程系碩士班
96
The major spirit of TAB/Cx is confirmed that the entirety function and performance of HVAC system since design, construction, install, functional test to system operation and maintenance and achieve the whole function of design intent.This article illustrates the ice storage system with TAB/Cx to raise the advantageous that ice storage volume, saved power bill, reduce contract volume effectively and spread the limited power crisis etc. by the example of office buildings in Taipei. With the DOE-2 software simulation result to discuss the TAB/Cx achievement points, it illustrates the benefit to owner, the necessary professional of design, supervisor and PCM Unit and the improvement quality of Construction businesses. Hope to supply the objective simulation and actual teat value to supply the all walk of life for pay attention to the importance of TAB/Cx and try the best effort to adjust the original design intent with accepted ice storage system for the devices works with optimize and reduce to waste energy to achieve the stuff feel comfortable in the building.The result indicates that the ice storage HVAC system raises 924RT-HR ice storage volume has been implemented TAB/Cx and then to achieve the design reference values. It not only makes the equipments develop the optimum efficiency and useful life, but also avoids improper selection equipment to add performing cost. Compare the consumption and power bill of the design values and real testing result with e-Quest software simulation, the result is that when the HVAC system installed ice storage equipments, the total consumption follows the ice storage volume add, but the power bill reduce. Finally, compare the result and verify the inaccuracy value is closed by the software simulation and the saved service cost that the before and after implement TAB/Cx commission.
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Huang, Chih-Wei, i 黃志維. "Effects of CH4 flow ratio on the structure and properties of reactively sputtered (CrNbSiTiZr)Cx coatings". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/29629150254084387236.
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Chen, Shih Ji, i 陳世基. "Rational Design of Amide Ligand Precursors to Prepare Abnormal and Normal Carbene Complexes and CX-type Palladacycles". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/05316004699868353783.
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碩士國立彰化師範大學
化學系
101
The preparation of a series of ligand precursors featuring imidazo[1,2-a]pyridine and amido functional groups is reported. The reactions between the new ligand precursors, pyridine, and palladium acetate in DMF afforded monodentate Pd(II) abnormal carbene complexes. An isomeric Pd(II) normal carbene complex with a formally identical steric environment to that of the abnormal carbene counterpart was also prepared. The isomeric pairs were characterized by X-ray structural studies. Under a different complexation condition of employing PdCl¬2 as metal precursor, a CC-type palladacycle formed by the C–H activation at the ortho-N-phenyl and methylene carbons was obtained. The use of a similar ligand precursor with a NH instead of NMe group produced a palladalactam complex. In contrast to the previous work in the literature, due to the rigidity of the fused heterocyclic ring, the palladalactam complex did not undergo intramolecular proton transfer via the coordinated N atom. Overall, we demonstrated that proper modification of the structures of ligand precursors and complexation conditions allowed us to obtain a full range of intriguing Pd(II) complexes including abnormal and normal carbene complexes, palladalactam, and CC-type palladacycles via A–H bond (A = N, C) activations.
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Weigel, Martin Christian [Verfasser]. "Molekulargenetische und physiologische Analysen von Plastocyanin und Cytochrom-cx-Mutanten bei Arabidopsis thaliana / vorgelegt von Martin Christian Weigel". 2006. http://d-nb.info/979203767/34.
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Liu, Jungtung, i 劉榮東. "From the point of healthy dominance to inspect medical device industry in Taiwan - A case study of CX company". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/99668239310153357980.
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碩士東海大學
管理碩士在職專班
100
In the past 30 years, medical device industry was regarded as another economic miracle by Taiwan government. In recent years, although the trade quantity of medical devices had a slight increase, the majority of products were classified as low-end or easily-involved equipment such as blood sugar testing machine, blood pressure monitor or electric wheelchair. These products have not only narrow profits, but have no much help for medical care quality upgrading. In fact, as Dr. 翁啟惠Academia Sinica Dean said, the outcome of development on medical device in Taiwan was disappointed. Before 1949, the medical system in Taiwan was established by Japan. Since then, English becomes a major foreign language by education system due to the government encouraged, the medical caring model and knowledge sources were shifted to US-based healthy system. Most of medical-related materials were imported from US or other countries which were licensed by FDA. There are almost no high-end equipments which were designed or manufactured in Taiwan. People will pay higher cost to maintain our healthy system, on the other hand, Taiwan would not be able to dominate the trends of medical care. The nature of healthy care should be interacted with economic activities. How to integrate the energy of government, industry and academia to formulate a workable policy is the main discourse of this article. This paper was assembled and summarized aspirations by interviewing a key CEO of a selected high-tech domestic company, 20 experienced clinical practitioners and analysis the success factors of foreign companies and made following conclusions: (A)The policy-making should be included the characteristics of the domestic medical industry, the R & D performance of academia, revising and discarding the outdated regulation. (B)The industry has to respect the value of intellectual properties and provide an attractive incentives to inspire the medical practitioners to join R & D. (C)Practitioners should be kept in mind to find out the possible way to resolve the medical drawback anytime.
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Chia-LingTsai i 蔡佳綾. "Investigating the Functional Interplay and Interaction Sites between Hepatitis C Virus Core Protein and a Cellular Protein CX for HCV replication". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/tb3q27.
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Emadi, Matthew Habib. "The royal priest: Psalm 110 in biblical-theological perspective". Diss., 2016. http://hdl.handle.net/10392/5178.
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ABSTRACT
THE ROYAL PRIEST: PSALM 110 IN BIBLICAL-
THEOLOGICAL PERSPECTIVE
Matthew Habib Emadi, Ph.D.
The Southern Baptist Theological Seminary, 2016
Chair: Dr. James M. Hamilton, Jr.
This dissertation develops the biblical-theological rationale for the union of kingship and priesthood in Psalm 110 in the context of the entire canon. The thesis of this project is that a canonical reading of David’s depiction of the eschatological Melchizedekian priest-king develops God’s creational purpose for humanity to establish God’s kingdom (king) by mediating God’s covenantal blessings from his temple sanctuary (priest), and simultaneously advances God’s redemption project by depicting the order of royal priesthood that would bring the promises of the Abrahamic covenant to fruition.
Chapter 1 introduces the thesis and methodological issues pertaining to this study, and surveys the research in the modern period in order to identify how scholars have handled the union of kingship and priesthood in a single figure in Psalm 110.
Chapter 2 examines the concept of royal priesthood in the Torah. This examination demonstrates that Adam is the Bible’s royal priestly prototype and that his royal priesthood is recapitulated in important covenantal figures—Noah, Abraham, Melchizedek, Israel, and Aaron. Melchizedek, in particular, is a priest-king uniquely associated with Abraham and the Abrahamic covenant.
Chapter 3 situates Psalm 110 in its Old Testament context and hones in on the patterns of David’s own life experiences—revealed in 1–2 Samuel—and the content of the Davidic covenant in order to show how David would have arrived at the conclusion that the messiah was to be a royal priest after the order of Melchizedek.
Chapter 4 briefly investigates the intertestamental literature in order to show how the union of priesthood and kingship in Psalm 110 influenced the messianic expectations of the authors of the Testament of Levi, 1 Enoch, 2 Enoch, and 11QMelchizedek.
Chapter 5 focuses on how the New Testament develops the union of priesthood and kingship in the person and work of Jesus Christ on the basis of Psalm 110. The Gospel of Mark and the epistle to the Hebrews pick up the royal priestly logic of Psalm 110 in their respective Christological arguments.
Chapter 6 is the conclusion. It summarizes the arguments of the previous chapters and proposes some theological implications from this study.
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Nilsson, Morgan. "Morgondagens handel : Smartmobilen länken till en sömlös upplevelse". Thesis, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-15963.
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Konkurrensen inom detaljhandeln har blivit allt tuffare sedan internets uppkomst vilket har lett till att kunders beteende har börjat förändrats, samtidigt som upplevelsen både på internet och iden fysiska butiken har hamnat alltmer i fokus. En bra användarupplevelse och kundupplevelseär idag en av de viktigaste konkurrensfördelarna ett företag kan ha inom detaljhandeln. Forskning inom detaljhandeln har visat att kunder idag efterfrågar bättre personliga upplevelser vid rätt tidpunkt och plats, vilket smartmobilen potentiellt skulle kunna uppfylla i den fysiskabutiken. Studiens syfte är således att undersöka om upplevelsen i den fysiska butiken potentiellt skulle kunna förbättras av dagens smartmobiler, studien har avgränsats till kläd- och skobutiker. Genom att besvara problemformuleringen kan studien inte endast förhoppningsvis hjälpa dagens fysiska butiker att potentiellt förbättra upplevelsen för sin kunder utan även ge forskningen nya insikter om hur den digital och fysiska världen kan sammanföras i ett. Resultatet av examensarbetet indikerar att smartmobilen kan förbättra upplevelsen för kunden genom attsammanväva den personliga informationen från internet med den fysiska butikens sortiment och layout.57 s. totalt, inkl. bil.
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Garcia, Christopher. "Caractérisation morphologique, biochimique et physiologique des protéines de jonction lacunaire, les connexines 46 et 50, dans les cellules folliculo-stellaires TtT/GF de l’hypophyse antérieure". Thèse, 2014. http://hdl.handle.net/1866/19225.
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Les cellules folliculo-stéllaires (FS) de l'hypophyse antérieure possèdent une forme étoilée et étendent de longues projections cytoplasmiques qui forment des pseudo-follicules entourant les cellules endocrines. Les cellules FS sont connectées entre elles par des jonctions lacunaires (des fois aussi connu sous le nom de jonction communicante) formant ainsi un réseau tridimensionnel continu. Un des rôles principaux des cellules FS est le maintien du microenvironnement de l'hypophyse antérieure, une activité qui est en partie réalisée par la sécrétion de divers facteurs de croissance et de cytokines. Ces messagers chimiques, y compris le bFGF, le VEGF, l’IL-6 et l’IL-1 contrôlent de nombreux processus cellulaires tels que l’expression des gènes d’hormones. Notre intérêt est de déterminer si la communication entre les cellules FS contribue à leur activité régulatrice. Dans notre étude, nous avons utilisé la lignée cellulaire TtT/GF qui partage de nombreuses caractéristiques morphologiques, physiologiques et biochimiques avec les cellules FS.
Les jonctions lacunaires/communicantes sont formées par l’association de deux connexons de cellules adjacentes qui unissent le cytoplasme des cellules connectées et permet la diffusion de petites molécules. Chaque connexon est formé par l’oligomérisation de six protéines connexine (Cx) de la famille α, β ou γ. Les connexons, intégrés dans la membrane d’une vésicule du cytoplasme, se migrent vers la membrane cellulaire où ils s’incorporent dans la couche bilipidique.
L’expression de la Cx43 (α) par les cellules FS est régulée en réponse à des facteurs de croissance et des cytokines. Des changements dans le microenvironnement de l'hypophyse antérieure causés par des molécules de signalisation sont susceptibles de modifier la Cx43, en particulier l’état de phosphorylation de la protéine. Ces modifications de la Cx43 peuvent ensuite déclencher des changements du comportement de jonctions lacunaires/communicantes formées par la Cx43, comme leur perméabilité et le renouvellement de la protéine Cx43.
Les tissus expriment généralement plus d’un type de connexine. Jusqu’aujourd’hui, la Cx43 est la seule connexine à avoir été identifiée dans les cellules FS. Le cristallin exprime les connexines α: Cx43, Cx46 et Cx50. Leur expression est modulée par des facteurs de croissance. Notre hypothèse de travail a été de vérifier si la Cx46 et la Cx50 étaient exprimées par les cellules FS et si celles-ci contribuaient au rôle modulateur des cellules FS hypophysaires.
Dans cette étude, nous avons identifié et caractérisé la Cx46 et la Cx50 dans la lignée cellulaire TtT/GF. Nous avons identifié les produits de transcription de Cx46 et de Cx50 par la technique d’analyse northern blot (PCR). Par la suite, les protéines Cx46 et Cx50 ont été identifiées en utilisant des anticorps dans des analyses western blot. Par microscopie confocale, nous avons déterminé la co-localisation de la Cx46 avec certaines marqueurs d’organites : réseau trans-Golgien, endosomes précoces et lysosomes. La Cx50 co-localise avec des marqueurs du réticulum endoplasmique, du réseau cis-Golgien et des endosomes précoces. Un protocole d’isolation des membranes résistantes aux détergents non-ionique a révélé que la Cx46 et la Cx50 n’étaient pas associées à des radeaux lipidiques ni aux cavéoles. Cependant, la microscopie confocale a montré une co-localisation cytoplasmique de la Cx50 et de la flotilline-1.
Nous avons poursuivi l’étude sur la localisation de la Cx46 dans le noyau en utilisant une technique d’isolation des fractions enrichies en noyau. Nous avons établi que plusieurs isoformes de la Cx46 sont exclusivement associées au noyau. De plus, avec la microscopie confocale nous avons démontrée une co-localisation de la Cx46 avec un marqueur du nucléole/corps de Cajal.
Nous avons démontré un effet du bFGF sur l'expression temporelle de la Cx46 et de la Cx50. L’expression de la Cx46 diminue au cours de longues expositions au bFGF tandis que les niveaux de Cx50 augmentent de façon transitoire au cours du traitement. Dans une autre étude nous avons démontré des changements importants dans les niveaux de la Cx46 et de la Cx50 dans l’hypophyse antérieure des visons durant le cycle de reproduction annuel.
Notre étude démontre que les cellules FS expriment la Cx46 et la Cx50. Nous avons aussi établi que la Cx46 et la Cx50 sont localisées dans différentes structures sous-cellulaires, ce qui suggère des rôles différents dans les cellules FS pour ces protéines de jonction lacunaire/communicante. Il est possible que la Cx46 et la Cx50 ne jouent pas un rôle majeur dans la communication intercellulaire dans les cellules FS quiescentes. Nos résultats suggèrent que la Cx46 et la Cx50 peuvent avoir d'autres fonctions : des isoformes de la Cx46 peuvent contribuer à la biogenèse des ribosomes tandis que la Cx50 pourrait avoir un rôle dans la communication dans les cellules stimulées au bFGF. Nos études établissent une base pour des recherches futures.The folliculo-stellate (FS) cells of the anterior pituitary are star-shaped and extend long cytoplasmic processes forming pseudo-follicles encircling hormone-secreting cells. Dispersed throughout the anterior pituitary gland, FS cells are joined to form a continuous three dimensional network through communicating gap junctions. One of the primary roles of FS cells is the maintenance of the anterior pituitary microenvironment, accomplished through the expression and secretion of various growth factors and cytokines. These chemical messengers, including bFGF, VEGF, IL-6 and IL-1 mediate a range of cellular processes such as hormone gene expression. Our aim is to study whether intercellular communication among FS cells contributes to the modulatory activity of the FS cells within the anterior pituitary gland. To pursue this, we use the TtT/GF cell line that shares many morphological, physiological and biochemical characteristics with FS cells. Gap junctions are formed by the joining of two connexons/hemichanels from adjacent cells that link their cytoplasms allowing for the passive diffusion of small molecules. Connexons/hemichannels are themselves formed by the oligomerization of six connexin (Cx) proteins from the family α, β or γ, which then migrate into the lipid bilayer of the cell membrane. FS cells express Cx43 (α-connexin), which is regulated in response to growth factors and cytokines. Changes in the anterior pituitary microenvironment due to signaling molecules results in modifications to Cx43, particularly in the phosphorylation status of the protein. Such alterations yield alterations in the physiological behaviour of Cx43 gap junctions such as permeability and turnover. Tissues generally express more than one connexin type and to date, Cx43 has been the sole connexin to be identified in FS cells. The ocular lens expresses the α-connexins: Cx43, Cx46 and Cx50, which are modulated by growth factors that are also present in the anterior pituitary. Based on these facts, we hypothesize that Cx46 and Cx50 are also expressed by the FS cells and contribute to the FS modulatory role in the anterior pituitary gland. In the present study, we have identified and characterized Cx46 and Cx50 in the TtT/GF cell line. We identified Cx46 and Cx50 transcripts through northern blots and identified the corresponding protein products using antibodies and western blot analyses. Through confocal microscopy, we determined that Cx46 co-localized with the organelle markers: trans-Golgi, early endosomes and lysosomes. Cx50 co-localized with markers for the ER, cis-Golgi and early endosomes. An isolation procedure using a non-ionic detergent we showed that neither Cx46 nor Cx50 were associated to lipid rafts or caveolae. However, confocal microscopy showed a cytoplasmic co-localization between Cx50 and flotillin-1. We pursued a finding that localized Cx46 to the nucleus and using a nuclear isolation technique, demonstrated that several isoforms of Cx46 are exclusively located in the nuclear compartment. Furthermore, with confocal microscopy we found a co-localization of Cx46 with a nucleolus/coiled body marker. We demonstrated an effect of bFGF on the temporal expression patterns of Cx46 and Cx50 and showed that Cx46 levels decreased over longer exposures to the growth factor while Cx50 levels transiently increased. Lastly, drastic changes were noted in an in situ study of Cx46 and Cx50 in the male and female mink anterior pituitary during the annual reproductive cycle. Our study indicates that addition to Cx43, FS cells also express Cx46 and Cx50. We also demonstrated that Cx46 and Cx50 localize to different sub-cellular structures, suggesting different roles in the FS cells. While they may not play a major role in intercellular communication in quiescent FS cells, our results suggest that Cx46 and Cx50 may serve other functions: Cx46 isoforms may contribute to ribosome biogenesis and Cx50 may have communication-related responsibilities in stimulated cells. Importantly, our identification and characterization studies provide a foundation on which future studies can be built.
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Canadas, Nuno Miguel Evangelista. "Modelação da parte física de sistemas mecatrónicos e estudo da sua influência em simulação MiL (Model-in-the-loop)". Master's thesis, 2013. http://hdl.handle.net/1822/28206.
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Dissertação de mestrado integrado em Engenharia MecatrónicaA implementação de sistemas automatizados na indústria implica o treino de pessoal especializado para trabalhar/desenvolver sistemas constituídos por autómatos programáveis (vulgarmente denominados como PLC’s, do inglês programmable logic controller), sensores e atuadores de vários tipos e funções, desde o simples comando de uma válvula até complexos controladores de processos. A principal vantagem desta plataforma de simulação é a possibilidade de fornecer aos alunos novas estratégias e metodologias de aprendizagem, tendo como base as práticas laboratoriais direcionadas ao que irão encontrar no mercado de trabalho. Através da utilização do seu computador pessoal, os alunos serão capazes de aprender ao seu próprio ritmo, autonomamente, tendo a capacidade de descobrir e incidir na resolução das suas próprias dificuldades. Esta dissertação apresenta todo o processo de construção de plataformas de simulação virtuais de sistemas automatizados, réplicas de sistemas reais, para que o controlo do sistema possa ser simulado virtualmente utilizando a simulação Model-In-the-Loop. Devido às vantagens destes processos, esta plataforma foi desenvolvida no contexto do ensino da área de automação aos estudantes das várias áreas da Engenharia. Dado isto, ao longo desta tese são enunciados todos os passos para o desenvolvimento da plataforma, assim como os formalismos e ferramentas utilizados.
The implementation of automated systems in the industry involves training specialized personnel to work / develop systems consisting of programmable logic controllers (commonly referred to as PLC's), sensors and actuators of various types and functions, from the simple command of a valve to complex processes controllers. The main advantage of this simulation platform is the ability to provide students new learning strategies and methodologies, based on laboratory practices directed at what they will find in their labor market. Through the use of their personal computer, students will be able to learn at their own pace, independently, having the ability to discover and focus on solving their own problems. This thesis presents the entire process of building platforms for virtual simulation of automated systems, replica of real systems, so that the control system can be simulated using the simulation virtually Model-In-the-Loop. Due to the advantages of these processes, this platform has been developed in the context of teaching automation to the students of the most extensive areas of Engineering. Given that, along this thesis are listed all the steps for the development of the platform, as well as formalisms and tools used.