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Artykuły w czasopismach na temat "Correspondence Score (CRS)"
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Wang, Xinhua, Yu Chang, Dandan Zhu, Shiyong Li, Shuaipeng Geng, Yinyin Chang, Yan Chen, Mao Mao i Mingzhi Zhang. "Integrating Circulating Tumor DNA Features and Plasma Protein Markers to Detected Early Lymphoid Neoplasm". Blood 138, Supplement 1 (5.11.2021): 4489. http://dx.doi.org/10.1182/blood-2021-145683.
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Abstract Introduction The disease burden of lymphoid neoplasm has been rising in China over the last decade. But most patients manifest with advanced stage disease at initial diagnosis, and the prognosis is poor with a 5-year survival rate of 38.3%. Here we reported a novel multivariate cancer risk score (CRS) model which is used to detect early lymphoid neoplasm from the peripheral blood. It incorporates three cancer hallmarks, copy number aberrations (CNA) and fragment size (FS) via shallow whole genome sequencing (sWGS) from cell-free DNA (cfDNA), and a panel of seven tumor protein markers in a single blood draw (10ml). Methods 44 newly diagnosed and untreated stage I-IV lymphoid neoplasm patients and 247 healthy individuals with no cancer diagnosis were enrolled in this study. 10ml peripheral blood was collected from each participant after enrollment. cfDNA was extracted and subjected to sWGS whereas plasma was subjected to measure the levels of 7 PTMs. The cancer risk score (CRS) of a subject was calculated via an established CRS model [1]. Results Firstly, genomic and epigenetic features were explored from cfDNA sWGS results. CNA is a ubiquitous genomic hallmark in a wide spectrum of cancers. In this study, 26 of the 44 (59.1%) lymphoid neoplasm patients had CNA in at least one genomic segment (>5Mb). FS feature of cfDNA bears the correspondence of the epigenetic landscapes of cells that give rise to those cfDNA fragments. When CNA was combined with FS, 29 (65.9%) patients were able to be detected by the CNA+FS classifier. On the other hand, 13 (29.5%) patients were tested positive by PTMs alone, indicating non-DNA molecular surrogates can also serve as cancer biomarkers with acceptable performance. When CNA, FS and PTM were incorporated into a multidimensional and multivariate CRS model, it achieved the best performance allowing 31 (70.0%) lymphoid neoplasm cases to be identified with a positive predictive value (PPV) of 86.1% at 98.0% specificity. The sensitivity of CRS model increases with the advances of disease with a sensitivity of 50.0% in early stage (stage I -Ⅱ) and 90.0% in late stage (stage Ⅲ-Ⅳ). Conclusion In summary, this study provides an efficient and non-invasive method to detect lymphoid neoplasm. Instead of relying only on one dimension of cancer markers, the multidimensional approach which incorporating CNA, fragment size and protein markers is plausible in early detection of lymphoid neoplasm with sufficient accuracy and robustness. Disclosures Zhu: Clinical Laboratories, Shenyou Bio: Current Employment. Li: SeekIn Inc.: Current Employment, Current holder of individual stocks in a privately-held company. Geng: Clinical Laboratories, Shenyou Bio: Current Employment. Chang: Clinical Laboratories, Shenyou Bio: Current Employment. Chen: SeekIn Inc: Current Employment, Current holder of individual stocks in a privately-held company. Mao: SeekIn Inc: Current Employment, Current holder of individual stocks in a privately-held company.
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Frengley, J. Dermot, Giorgio R. Sansone i Robert J. Kaner. "Chronic Comorbid Illnesses Predict the Clinical Course of 866 Patients Requiring Prolonged Mechanical Ventilation in a Long-Term, Acute-Care Hospital". Journal of Intensive Care Medicine 35, nr 8 (1.10.2018): 745–54. http://dx.doi.org/10.1177/0885066618783175.
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Objective: To determine whether burdens of chronic comorbid illnesses can predict the clinical course of prolonged mechanical ventilation (PMV)patients in a long-term, acute-care hospital (LTACH). Methods: Retrospective study of 866 consecutive PMV patients whose burdens of chronic comorbid illnesses were quantified using the Cumulative Illness Rating Scale (CIRS). Based on increasing CIRS scores, 6 groups were formed and compared: group A (≤25; n = 97), group B (26-28; n = 105), group C (29-31; n = 181), group D (32-34; n = 208), group E (35-37; n = 173), and group F (>37; n = 102). Results: As CIRS scores increased from group A to group F, rates of weaning success, home discharges, and LTACH survival declined progressively from 74% to 17%, 48% to 0%, and 79% to 21%, respectively (all P < .001). Negative correlations between the mean score of each CIRS group and correspondent outcomes also supported patients’ group allocation and an accurate prediction of their clinical course (all P < .01). Long-term survival progressively declined from a median survival time of 38.9 months in group A to 3.2 months in group F ( P < .001). Compared to group A, risk of death was 75% greater in group F ( P = .03). Noteworthy, PMV patients with CIRS score <25 showed greater ability to recover and a low likelihood of becoming chronically critically ill. Diagnostic accuracy of CIRS to predict likelihood of weaning success, home discharges, both LTACH and long-term survival was good (area under the curves ≥0.71; all P <.001). Conclusions: The burden of chronic comorbid illnesses was a strong prognostic indicator of the clinical course of PMV patients. Patients with lower CIRS values showed greater ability to recover and were less likely to become chronically critically ill. Thus, CIRS can be used to help guide clinicians caring for PMV patients in transfer decisions to and from postacute care setting.
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Simpson, Andrew, i Arunima Choudhury. "The Nonuniform Syntax of Postverbal Elements in SOV Languages: Hindi, Bangla, and the Rightward Scrambling Debate". Linguistic Inquiry 46, nr 3 (lipiec 2015): 533–51. http://dx.doi.org/10.1162/ling_a_00191.
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Much debate in recent years has focused on whether postverbal elements (PVEs) in SOV Hindi are derived via leftward movement compatible with the Linear Correspondence Axiom ( Mahajan 1997a , b , 2003 ) or whether they must be assumed to result from some kind of rightward non-antisymmetric movement ( Bhatt and Dayal 2007 , Manetta 2012 ). A second phenomenon, scope restrictions on wh-in- situ elements in postverbal CPs, is often linked to the syntactic analysis of PVEs. Comparing Hindi with Bangla, this article shows that PVEs in Indic languages are not derived in a uniform way and that the wh-scope restriction needs to be considered independently of the syntax of nonclausal PVEs.
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Ishihara, Masumi, Tami Saito, Takashi Sakurai, Hiroyuki Shimada i Hidenori Arai. "Effect of a Positive Photo Appreciation Program on Depressive Mood in Older Adults: A Pilot Randomized Controlled Trial". International Journal of Environmental Research and Public Health 15, nr 7 (12.07.2018): 1472. http://dx.doi.org/10.3390/ijerph15071472.
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Safer and more effective programs are required to cope with an increasing number of older people with depression. Hence, we developed the Positive Photo Appreciation (PPA) program. A three-month pilot randomized controlled trial was conducted with healthy Japanese individuals aged 65–84 years, assigned to a PPA group (n = 28) or Photo Correspondence Education (PCE) (control group) (n = 27). We used the Center for Epidemiologic Studies Depression Scale (CES-D) score as the primary outcome measure. Secondary outcome measures, among others, were cognitive function and positive emotion. Data collected at baseline and post-intervention were analyzed using a linear mixed-effect model. Over 80% of the participants in the PPA group completed and were satisfied with the program. Compared with the PCE group, the CES-D score in the PPA group significantly improved (main effect of group: t = −4.30, p < 0.001; interaction effect of group by time: t = 4.39, p < 0.001), with an effect size of d = 1.23. Additionally, a positive significant interaction effect of group by time was found in the Positive and Negative Affect Schedule (t = −2.33, p = 0.024). The PPA program might be promising for mitigating depressive mood in older adults.
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Moebus, Susanne, i Wolfgang Boedeker. "Case Fatality as an Indicator for the Human Toxicity of Pesticides—A Systematic Scoping Review on the Availability and Variability of Severity Indicators of Pesticide Poisoning". International Journal of Environmental Research and Public Health 18, nr 16 (5.08.2021): 8307. http://dx.doi.org/10.3390/ijerph18168307.
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Objective: To investigate if case fatality and other indicators of the severity of human pesticide poisonings can be used to prioritize pesticides of public health concern. To study the heterogeneity of data across countries, cause of poisonings, and treatment facilities. Methods: We searched literature databases as well as the internet for studies on case-fatality and severity scores of pesticide poisoning. Studies published between 1990 and 2014 providing information on active ingredients in pesticides or chemical groups of active ingredients were included. The variability of case-fatality-ratios was analyzed by computing the coefficient of variation as the ratio of the standard deviation to the mean. Findings: A total of 149 papers were identified of which 67 could be included after assessment. Case-fatality-ratio (CFR) on 66 active ingredients and additionally on 13 groups of active ingredients were reported from 20 countries. The overall median CFR for group of pesticides was 9%, for single pesticides 8%. Of those 12 active ingredients with a CFR above 20% more than half are WHO-classified as “moderately hazardous” or “unlikely to present acute hazard”. Two of seven pesticides considered “unlikely to present hazard in normal use” showed a CFR above 20%. The cross-study variability of reported case fatality was rather low. Studies most often utilized the Glasgow Coma Score for grading the severity of poisoning. Conclusion: Although human pesticide poisoning is a serious public health problem, an unexpectedly small number of publications report on the clinical outcomes within our study period. However, CFRs of acute human pesticide poisoning are available for several groups of pesticides as well as for active ingredients showing moderate cross-study variability. Our results underline that CFR is an indicator of the human toxicity of pesticides and can be utilized to prioritize highly hazardous pesticides especially since there is limited correspondence between the animal-test-based hazard classification and the human CFR of the respective pesticide. The reporting of available poisoning data should be improved, human case-fatality data are a reasonable tool to be included systematically in the periodic statutory review of pesticides and their regulation.
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Wang, Xiaochuan, Susanny Beltran, Denise Gammonley, Norma Conner i Milo Leon. "Examining the Relationship Between Hospice Agency Characteristics and Complaint Deficiencies". Innovation in Aging 5, Supplement_1 (1.12.2021): 1003. http://dx.doi.org/10.1093/geroni/igab046.3598.
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Abstract The U.S. hospice industry has expanded over the last decade. Similar to nursing homes, research guided by the Donabedian framework has documented quality differences in hospice based on agency characteristics, including profit status and rural status. Yet, compared to nursing homes, quality oversight and transparency in hospice remain limited. When families report substandard care, a complaint survey is launched to investigate allegations. Using publicly available regulatory oversight data (e.g., CMS QCOR, Medicare PACPUF, CAHPS HIS, Hospice Compare), and guided by the Donabedian framework, this study describes hospice agency structure and process characteristics associated with care complaint deficiencies (outcome). Of the 4,415 hospice facilities examined, 453 (or 10.3%) have had complaint survey deficiency citations between January 2018 and December 2020. Chi-square and ANOVA tests were conducted to compare facility characteristics (e.g., ownership status, percentage of Medicare beneficiaries in rural zips), nursing and social work involvement, and CAHPS scores between hospices with and without complaint survey deficiencies. Results indicated that the average proportion of beneficiaries with a rural zip for Medicare correspondence was significantly lower in hospices with deficiencies (p<.001). Finding also suggested that weekly total nursing and social work minutes were significantly higher in hospices with deficiencies. Additionally, family ratings of hospice team communication, symptom management, and overall satisfaction were higher in facilities without complaint survey deficiencies. Future research and practice implications will be discussed.
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Benyahya, M., A. Ouasri, M. Bouziani Idrissi, N. Dkhireche, H. Zarrok, Z. Sadoune i H. Oudda. "ANALYSIS OF MOROCCAN STUDENT PERFORMANCE IN ELECTRICITY IN CORRELATION WITH MATHEMATICS AND FRENCH BY THE MULTIPLE CORRESPONDENCE ANALYSIS METHOD: CASE OF IBN TOFAIL UNIVERSITY". Journal of Southwest Jiaotong University 57, nr 5 (30.10.2022): 488–502. http://dx.doi.org/10.35741/issn.0258-2724.57.5.39.
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This study focuses on the statistical analysis of the performance of students of different ages in solving electricity problems, after learning Physical Matter Sciences (PMS), Chemical Matter Sciences (CMS), Mathematical Sciences and Applications (MSA) and Mathematical and Computer Sciences (MCS) programs in the first year at Ibn Tofail University in Morocco. The student’s scores were obtained in mathematics (analysis and algebra), French, and electricity exams in terms of the 2017/2018 year. The data collected from the written student responses in the electricity exams were analyzed by SPSS software (version 25) using the multiple correspondence analysis method to study the influence of diverse variables: gender (M/F), age, and performance in analysis, algebra and French. The Cronbach's alpha coefficient (0.81) reflects the consistency and reliability of the used method, where 50% of the variability is explained by Dimension 1, and 36% is explained by Dimension 2. The discussion is made on the basis of previous studies conducted in secondary and university cycles of various contexts. It was found that students who perform better in solving electricity problems do not necessarily have a high level in the French teaching language. The teaching language correlates weakly with students' performance in solving electricity problems and their learning electrical concepts and phenomena. A positive correlation between performance in mathematics, particularly algebra, and performance in electricity is confirmed as stated elsewhere. So, the learning electricity at the university level cannot be done without deep mathematical knowledge. The analysis showed that the performance in electricity was not affected by the gender and age of the students.
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Baylé, Franck J., Marie Chantai Bourdel, Hervé Caci, Philip Gorwood, Jean-Michel Chignon, Jean Adés i Henri Lôo. "Structure factorielle de la traduction française de l'échelle d'impulsivité de Barratt (BIS-10)". Canadian Journal of Psychiatry 45, nr 2 (marzec 2000): 156–65. http://dx.doi.org/10.1177/070674370004500206.
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Même si le concept d'impulsivité demeure sujet à controverses, de nombreuses d'approches ont été tentées pour mesurer cette dimension. Seules les mesures psychométriques possèdent une bonne validité consensuelle et semblent aujourd'hui opérationnelles en routine. Barratt a élaboré la plus ancienne échelle mesurant spécifiquement l'impulsivité. De nombreuses révisions ont permis d'en améliorer la validité. Nous avons traduit en français sans difficultés majeures la dixième version validée de cette échelle (Barratt Impulsivity Scale [BIS-10]) et exploré sa structure factorielle. Nous l'avons assortie d'un autoquestionnaire évaluant l'anxiété. Nous avons recruté au sein de la population générale 280 sujets âgés en moyenne de 36,9 ans (18 à 79 ans). L'âge des sujets exerce une influence faible mais significative sur les scores d'impulsivité. L'analyse en composantes principales (ACP) montre que les 9 premiers facteurs expliquent 55,6% de la variance. Une nouvelle ACP sur ces facteurs de premier ordre permet d'extraire 3 facteurs de second ordre. Ceux-ci correspondent bien au regroupement proposé par Barratt. Nos résultats confortent ceux de l'analyse initiale de l'échelle qui n 'ont pu être reproduits par la suite. Il s'agit, à notre connaissance, de la première traduction française d'un instrument qui évalue spécifiquement l'impulsivité et dont la structure factorielle a été étudiée dans la population générale.
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Ait Ziane, Sarrah, Hanène Belabbassi, Amina Benbellal, Menel Arkam, Hanène Hamza, Kheira Louz i Houria Kaced. "Evaluation of the orthopedic and functional status of congenital dislocations of neglected hips, surgically treated". Batna Journal of Medical Sciences (BJMS) 6, nr 2 (30.12.2019): 104–8. http://dx.doi.org/10.48087/bjmsoa.2019.6205.
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Introduction. La luxation congénitale de hanche (LCH) est une anomalie de l’articulation coxo-fémorale décrite comme une perte des rapports anatomiques entre les surfaces articulaires du fémur et de l’acétabulum, dépistable dès la naissance lors de l’examen systématique du nouveau-né, permettant le dépistage de la LCH, avec une prise en charge précoce, mais malgré cela, sa découverte peut être tardive, le plus souvent à l’âge de la marche au prix d’une boiterie. La prise en charge sera lourde et couteuse avec un retard scolaire constituant un véritable problème de santé publique. L’objectif de ce travail est d’étudier le retentissement de la découverte tardive de cette pathologie, sur le plan orthopédique (l’inégalité de longueur et l’attitude vicieuse des membres inférieurs ainsi que le flessum des hanches), et fonctionnel (la marche) avant et après traitement chirurgical. Matériel et méthode. Il s’agit d’une étude descriptive rétrospective comportant 46 hanches, chez 35 malades suivis pendant 10 ans (2005 à 2016), présentant une LCH uni ou bilatérale, découverte à l’âge de la marche, traitée tardivement (traitement chirurgical et/ou orthopédique) et ayant bénéficié d’un complément de prise en charge à notre niveau. Résultats. L’âge moyen de découverte est de 1,96 ± 1,41 an avec un sexe ratio (F/M) de 6. L’atteinte est le plus souvent unilatérale avec plus de 57% des cas, soit 20 cas, 9 droites et 11 atteintes gauches, contre 42 % d’atteinte bilatérale. L’âge moyen de la PEC est de 4,81 ± 2,95 ans. Il existe une amélioration significative du flessum de hanche (p<0,003). Il n’y a pas de différence significative dans la récupération de l’inégalité de longueur des membres inférieurs et celles de l’attitude vicieuse ainsi que la marche selon le score d’Aubigné. Discussion-Conclusion. La prédominance de l’atteinte unilatérale gauche de la hanche et celle du sexe féminin correspondent aux données de la littérature.Le retard de prise en charge chirurgicale qui a atteint 5 ans serait à l’origine de la non amélioration des amplitudes articulaires de la hanche, de l’attitude vicieuse ainsi que la fonction de la marche.
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Park, Eun-Young. "Factor Structure of the Short-Form of Center for Epidemiological Studies Depression Scale for People With Physical Disabilities". Frontiers in Psychiatry 12 (14.04.2021). http://dx.doi.org/10.3389/fpsyt.2021.536499.
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This study aimed to examine the factor structure of the short-form of Center for Epidemiological Studies Depression Scale (CES-D-11) using confirmatory factor analysis (CFA). We extracted data from 670 people with physical disabilities (PWPD) from the Korea Welfare Panel. To investigate the model fit regarding factor structure, a one-factor model, four-factor model, and four-factor within bifactor model, as reported in previous studies, were examined using CFA, and goodness-of-fit indices were compared. As a result of the analysis, the four-factor model and the four-factor within bifactor model satisfied the criteria of correspondence with goodness-of-fit indices. Reliability of the four individual factors ranged from 0.722 to 0.834, indicating acceptable reliability. Validity and reliability of the four-factor within bifactor structure was confirmed through CFA and reliability analysis. In future studies using the CES-D-11 to measure depression in PWPD, comparison between four sub-factors and total scores might be possible.
Rozprawy doktorskie na temat "Correspondence Score (CRS)"
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Gadiyaram, Vasundhara. "Graph Spectral Methods for Analysis of Protein Structures". Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4280.
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Network representation of protein structures is an information-rich mode of examining protein structure, dynamics and its interactions with biomolecules. Graph spectral methods are extremely useful and powerful in analysing complex networks. This thesis is concerned with development of graph spectral methods for analysing networks and applying them to protein structure analysis. Some of the key problems of network science that are addressed here are network similarity assessment and identification of key components in networks. A new network similarity score (NSS) has been developed and has shown to be useful in comparing different networks considering both local and global changes. The applicability of this scoring scheme as a protein structure model validation tool has been demonstrated using models from various sources such as CASP experiments, mutant structures and molecular simulation trajectories. Also, a method to identify nodes and edges crucial in the network has been developed using NSS and perturbation analysis.
Although the methods developed in the thesis are inspired by the topology and functions related to protein structures, they are general and are applicable to problems in many other disciplines.
Streszczenia konferencji na temat "Correspondence Score (CRS)"
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Cendrasilvinia, Herose, The Maria Meiwati Widagdo i Widya Christine Manus. "Burden and Quality of Life of Dependent Elderly Caregivers in Pakuncen Village Yogyakarta". W The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.01.08.
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Background: Elderly people face health problems associated with reduced health and increased disability. Dependent elderly on caregivers who cause a burden affecting the quality of life of caregivers. The aim of this study was to analyze the correlation between the burden and quality of life among dependent elderly caregivers. Subjects and Method: A cross-sectional study was carried out in Pakuncen Village, Yogyakarta. The study subjects were 30 informal caregivers who cared for their family member aged ≥ 60 years with moderate dependence. Instruments used to screen dependent elderly included Activities of Daily Living (ADL) and Instrument Activities of Daily Living (IADL) to measure level of independence, MMSE and AD-8 to assess cognitive function of elderly. Caregivers aged ≥ 60 years underwent MMSE and those with scores <24 was excluded. Caregivers’ burden ware measured using The Zarit Burden Interview (ZBI) and Caregiver Reaction Assessment (CRA). Measurements of quality of life among caregivers was conducted by WHOQOL-BREF. Data were analyzed using Spearman-rank correlation. Results: Out of 30 caregivers, 24 were female and 6 were male with an average age of 49 years. Most respondents had light to moderate burden (Mean= 34.27; SD=18.94). Caregivers’ quality of life were low (<60) in psychological (Mean= 58.17; SD= 12.31), social relation (Mean= 59.77; SD= 9.04), and the environment domains (Mean= 51.90; SD= 10.00). Caregivers’ quality of life was high (≥60) in physical health domain (Mean= 63.30; SD=12.83). There were negative correlations between caregiver burden (ZBI and CRA) and the quality life of caregivers (WHOQOL-BREF). Conclusion: In Yogyakarta, the burden of caregivers (ZBI and CRA) and the quality of caregivers’ lives (WHOQOL-BREF) are negatively correlated. Keywords: caregiver, burden, quality of life, dependent, elderly Correspondence: Herose Cendrasilvinia. Faculty of Medicine, Universitas Duta Wacana Christian, Yogyakarta. Jl. Dr. Wahidin Sudirohusodo 5-25 Yogyakarta, 55224. Email: herosecendrasilvinia@gmail.com. Mobile: 081226466770. DOI: https://doi.org/10.26911/the7thicph.01.08