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1
Chapel, Gwenda-ella. "Modélisation et diagnostic des conceptions d'élèves de niveau seconde sur l'information génétique, lors de l'élaboration d'expérience à l'aide de LabBrook". Phd thesis, Université de Grenoble, 2011. http://tel.archives-ouvertes.fr/tel-00721782.
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Les objectifs de ce travail (la modélisation et le diagnostic) sont réalisés grâce à la création et la mise en place d'une situation d'élaboration d'expérience où les élèves répondent au problème suivant : Comment modifier l'information génétique ? La situation de recueil des productions fait intervenir le site internet LabBook, comprenant plusieurs éditeurs dont COPEX, qui étaye l'activité d'élaboration de protocole expérimental. Cette situation permet de proposer un environnement de travail sur les neuf niveaux biologiques auxquels les élèves peuvent placer l'information génétique : Milieu, Organisme, Organe, Cellule, Noyau, Caryotype, Chromosome, Gène et ADN. Ces niveaux ont été déterminés à partir de l'étude de travaux sur les difficultés des élèves en génétique et d'une analyse épistémologique du savoir. La situation a été proposée à la suite d'une analyse a priori effectuée dans le cadre de la TSD de Brousseau (1998) et du modèle cK¢ de Balacheff (1995). L'analyse des productions d'élèves nous apporte des informations sur le niveau biologique auquel ils souhaitent réaliser leur expérience, sur l'objet biologique du niveau choisi, ainsi que le mode de modification de l'information génétique. Nous retrouvons un plus grand nombre de réponses aux niveaux Chromosome, Gène et ADN. Concernant les objets biologiques, ce sont ceux donnant leur nom aux niveaux qui sont les plus utilisés et la modification principale est un échange, une substitution. Le modèle cK¢ a aussi servi à formaliser les conceptions dégagées des productions des élèves. Nous avons pu modéliser neuf conceptions rassemblant la moitié des élèves et correspondant à la modification de l'information génétique.
2
Dufay, Amélie. "Conception et évaluation d'un vecteur ciblé de thérapie génique anticancéreuse destiné à la voie intraveineuse". Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00737496.
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L'administration intraveineuse d'ADN thérapeutique rencontre de nombreux obstacles liés à sa dégradabilité, ainsi qu'à sa difficulté à pénétrer les cellules en raison de sa taille importante et de son hydrophilie. Des lipoplexes conjugués à de l'acide hyaluronique (HA) de haut poids moléculaire ont été développés afin de délivrer de l'ADN plasmidique à l'intérieur de cellules cancéreuses exprimant le récepteur membranaire CD44, récepteur clé du développement tumoral. L'emploi d'HA conjugué au phospholipide DOPE (HA-DOPE) et d'un plasmide modèle GFP a permis d'obtenir des lipoplexes d'environ 250 nm, chargés négativement, protégeant efficacement l'ADN contre les nucléases et activant peu la fraction C3 du système du complément. Dans un modèle cellulaire exprimant CD44, la transfection optimale a été obtenue par l'utilisation de lipides avec 10% d'HA-DOPE complexés à de l'ADN selon un rapport 2:1. Ces lipoplexes sont internalisés par la voie des cavéoles et de façon dépendante du récepteur CD44. Cette formulation a été appliquée à la vectorisation d'un gène thérapeutique, codant pour le récepteur des estrogènes β (ERβ), qui est un potentiel suppresseur de tumeur. Sur un modèle in vivo de xénogreffes de cellules humaines de cancer du sein estrogéno-dépendant et exprimant CD44, la diminution du volume tumoral, ainsi que de l'indice de prolifération Ki67 ont permis de montrer l'effet anticancéreux par voie intraveineuse des lipoplexes conjugués à l'HA.
3
Adams, Patricia Lesley, i n/a. "The Implications for Artistic Expressions and Representations of Corporeality of the Experimental Techniques of Biomedical Engineering". Griffith University. Queensland College of Art, 2005. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20060707.144314.
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While biological scientists justify their research into human genetic engineering on the grounds of its 'therapeutic' potential, art - particularly the genre of science fiction (whose origins can be traced to Mary Shelly's famous tale, Frankenstein) - has acted on the social through culture to alert us to the perilous repercussions of usurping the role of the 'Creator of Life.' Now, at the dawn of the new millennium, the scientific project of mapping human DNA seemingly complete, the plight of the genetically-engineered human has become an intense focus of cultural critique. This doctoral project can be differentiated by its focus on aesthetic inquiry into the implications for expressions and representations of corporeality in relation to contemporary biomedical engineering. It has incorporated stem cell research that entails the manipulation and redirection of adult stem cell fates. The project takes the form of practical and theoretical investigations into cellular responses, and is framed within the matrices of both an innovative collaborative art/science research model and the evolving process of practice-led arts research. The exploratory research is discursively located within the system/environment paradigm. This allows for boundaries between the philosophic and scientific disciplines of: 1. epistemology, 2. ethics and aesthetics and 3. biology and technology to become nodes in a relational network associated with: 1. living and non-living, 2. sentience and consciousness and 3. conceptions of humanness. The cycle of practice-led research culminates in a body of work that began with a project entitled apoptosis, and developed into a three part quasi-scientific vital force series of installations. Each of these installations references nineteenth century scientific experimental processes employed in a search for the essential components of the human being itself. The series of interactive installations is discussed and the processual, pioneering research model, whereby the artist becomes the 'human guinea pig' is theoretically and visually articulated. In addition, time-lapse videomicrograph image data, collected through laboratory experiments is interpreted and recontextualised by the artist-researcher for representation in the vital force series of immersive installations. In these installations the implications of the issues raised by biomedical engineering processes are expressed as a very physical, tactile encounter. The aim is that these encounters engender a multi-sensory experience for the individual viewer, who, when immersed in the aesthetic, corporeal, interactive installations as a participant who completes the work through their engagement. Thus, the significance of the study lies in its re-privileging of the aesthetic experience of corporeality in the discourses surrounding genetic manipulation. This exegesis, like the doctoral project itself, is cyclical; following the inseparable processes of theory and practice through which the implications of the core research issues for a hybrid art/science practice are explored. It echoes the qualitative, post-positivist research methodology used throughout the project, which aimed to overcome the third person perspective through such strategies as interactivity and hybridity.
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Adams, Patricia Lesley. "The Implications for Artistic Expressions and Representations of Corporeality of the Experimental Techniques of Biomedical Engineering". Thesis, Griffith University, 2005. http://hdl.handle.net/10072/367521.
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While biological scientists justify their research into human genetic engineering on the grounds of its 'therapeutic' potential, art - particularly the genre of science fiction (whose origins can be traced to Mary Shelly's famous tale, Frankenstein) - has acted on the social through culture to alert us to the perilous repercussions of usurping the role of the 'Creator of Life.' Now, at the dawn of the new millennium, the scientific project of mapping human DNA seemingly complete, the plight of the genetically-engineered human has become an intense focus of cultural critique. This doctoral project can be differentiated by its focus on aesthetic inquiry into the implications for expressions and representations of corporeality in relation to contemporary biomedical engineering. It has incorporated stem cell research that entails the manipulation and redirection of adult stem cell fates. The project takes the form of practical and theoretical investigations into cellular responses, and is framed within the matrices of both an innovative collaborative art/science research model and the evolving process of practice-led arts research. The exploratory research is discursively located within the system/environment paradigm. This allows for boundaries between the philosophic and scientific disciplines of: 1. epistemology, 2. ethics and aesthetics and 3. biology and technology to become nodes in a relational network associated with: 1. living and non-living, 2. sentience and consciousness and 3. conceptions of humanness. The cycle of practice-led research culminates in a body of work that began with a project entitled apoptosis, and developed into a three part quasi-scientific vital force series of installations. Each of these installations references nineteenth century scientific experimental processes employed in a search for the essential components of the human being itself. The series of interactive installations is discussed and the processual, pioneering research model, whereby the artist becomes the 'human guinea pig' is theoretically and visually articulated. In addition, time-lapse videomicrograph image data, collected through laboratory experiments is interpreted and recontextualised by the artist-researcher for representation in the vital force series of immersive installations. In these installations the implications of the issues raised by biomedical engineering processes are expressed as a very physical, tactile encounter. The aim is that these encounters engender a multi-sensory experience for the individual viewer, who, when immersed in the aesthetic, corporeal, interactive installations as a participant who completes the work through their engagement. Thus, the significance of the study lies in its re-privileging of the aesthetic experience of corporeality in the discourses surrounding genetic manipulation. This exegesis, like the doctoral project itself, is cyclical; following the inseparable processes of theory and practice through which the implications of the core research issues for a hybrid art/science practice are explored. It echoes the qualitative, post-positivist research methodology used throughout the project, which aimed to overcome the third person perspective through such strategies as interactivity and hybridity.Thesis (Professional Doctorate)
Doctor of Visual Arts (DVA)
Queensland College of Art
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Chenu, Olivier. "Conception et validation d'un dispositif de suppléance perceptive dédié à la prévention des escarres". Phd thesis, Grenoble 1, 2009. http://tel.archives-ouvertes.fr/tel-00465531.
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Les escarres sont des plaies profondes causées par une compression mécanique des tissus. Les conséquences en termes de santé et d'économie sont dramatiques. Les personnes paraplégiques y sont particulièrement sujettes du fait de leur handicap moteur, mais surtout sensoriel leur empêchant de percevoir les signaux d'alerte naturels. Nous avons utilisé le paradigme de suppléance perceptive, consistant à suppléer un sens absent ou déficient en véhiculant les informations par une autre modalité, pour développer un dispositif dédié à rendre une perception des surpressions dangereuses aux personnes paraplégiques. Celui-ci consiste en une nappe de pressions posée sur l'assise du fauteuil et un stimulateur sensoriel tactile déclenché en cas de danger. Trois premières études ont montré l'efficacité du système sur des personnes valides et paraplégiques. Diverses études d'acceptabilité ont été menées et ont engendré des modifications profondes qui ont été validées à leur tour.
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Zeinyeh, Waël. "Conception et synthèse d'hétérocycles azotés et de dérivés stéroïdiens, modulateurs potentiels de transporteurs ABC (glycoprotéine-P)". Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00874305.
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La multichimiorésistance est caractérisée par une résistance simultanée à des agents chimiothérapeutiques de structures diverses, induite notamment par l'efflux des substances actives hors des cellules. Les transporteurs ABC (ATP-Binding Cassette) sont des protéines transmembranaires impliquées dans cet efflux et qui participent à l'échec du traitement de certains cancers. Par ailleurs, ce mécanisme d'efflux a également été évoqué dans le cadre de la résistance de certains microorganismes aux antimicrobiens. Dans cette étude, nous avons conçu et synthétisé des dérivés susceptibles d'inhiber certains transporteurs ABC, en particulier, la glycoprotéine-P (Pgp) impliquée dans la multichimiorésistance des tumeurs humaines, et CpABC3, rencontré chez le parasite Cryptosporidium parvum. Dans un premier temps, nous avons synthétisé trois dérivés de type 4-alkyl-imidazo[4,5-b]pyridin-7-one, hétérocycles destinés à se fixer sur le site à ATP des transporteurs ABC. L'activité de ces composés a été évaluée vis-à-vis d'un fragment recombinant (H6-NBD1) de CpABC3, et un de ceux-ci a montré une liaison (faible) à ce fragment. Nous avons ensuite préparé dix-sept dérivés bivalents susceptibles d'inhiber la Pgp, constitués d'une molécule d'adénine (ciblant le site à ATP) reliée à la progestérone (ciblant le site aux stéroïdes) par un bras de géométrie variable. Ces dérivés ont été testés sur des lignées cellulaires K562/R7 surexprimant la Pgp, et un de ceux-ci a montré une activité supérieure à celle de la progestérone. Enfin, nous avons mis au point une synthèse de chaînes de type oligocyclohexylidène, qui sont de bons candidats pour constituer des bras espaceurs rigides
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Aboussahoud, Wedad. "The role of toll-like receptors in assisted conception". Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-tolllike-receptors-in-assisted-conception(230bd2c9-e8bb-490f-b63f-9376667da89c).html.
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Background: In the last two decades the discovery of the Toll-Like Receptor (TLR) family in humans revealed the importance of innate immunity in providing host defence against invading pathogens. Moreover, TLRs have a vital role in mediating the interactions between the reproductive and immune systems. Similar to TLRs, (NOD)-like receptors (NLRs); retinoic acid-inducible gene-1, RIG-1-like receptors (RLRs) are also important pattern recognition receptors in the female reproductive system. Successful implantation requires effective reciprocal interactions between receptive endometrium and competent embryo. The endometrial innate immunity during implantation has been intensively investigated. However, little is known about the expression of innate immunity during the early stages of human embryo development. Objective: To investigate the expression of innate immunity molecules during the early stages of human embryo development and to determine the functions of TLRs in blastocysts. Material and methods: The expression of TLRs, a panel of downstream signalling molecules, NLRs, RLRs, inflammatory cytokines, chemokines and the hyaluronic acid system were investigated in the following developmental stages: oocyte, 4- cell, blastomeres, 8- cell, blastocyst, inner cell mass and trophectoderm using Affymetrix Human Genome U133 Plus 2.0 arrays. Microarray data were validated by Q-PCR. TLR function in human blastocysts was investigated by treating day five blastocysts with TLR3 or TLR5 specific ligands; Poly (I:C) and flagellin respectively, for 24 hours. The culture media was analysed for elevated cytokine and chemokine levels using cytometric bead array. Results: TLRs, NLRs, RLRs, TLR downstream signalling molecules, cytokines and chemokines involved during implantation event and the hyaluronic system were all found to be positively expressed in the early stages of human embryo development. The expression levels of the above molecules were generally moderate to low (CT 24-34) and varied across the embryonic developmental stages. Stimulation of TLR3 and TLR5 in day 5 blastocysts produced cytokines and chemokines. In addition, there were alterations in gene expression patterns in the Poly (I:C) and flagellin treated blastocysts in comparison to the untreated blastocysts. Conclusion: The varied expression levels of the investigated molecules involved in early embryonic developmental suggests a potential role for these molecules in early pregnancy loss and implantation failure. Specifically, the relationship between the level of TLR expression, function and embryo quality is worth investigating in the future as a potential marker for embryo competence.
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Byrd, Rebekah J., i K. Emelianchik. "College Students Conceptions of Relationship Violence". Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/2600.
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Stenbäck, Tomas. "Where Life Takes Place, Where Place Makes Life : Theoretical Approaches to the Australian Aboriginal Conceptions of Place". Thesis, Högskolan i Gävle, Religionsvetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-26156.
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The purpose of this essay has been to relate the Australian Aboriginal conceptions of place to three different theoretical perspectives on place, to find what is relevant in the Aboriginal context, and what is not. The aim has been to find the most useful theoretical approaches for further studies on the Australian Aboriginal conceptions of place. The investigation is a rendering of research and writings on Australian Aboriginal religion, a recording of general views on research on religion and space, a recounting of written material of three theoretical standpoints on place (the Insider standpoint, the Outsider Standpoint and the Meshwork standpoint), and a comparison of the research on the Aboriginal religion to the three different standpoints. The results show that no single standpoint is gratifying for studies of the Aboriginal conceptions of place, but all three standpoints contribute in different ways. There are aspects from all three standpoints revealing the importance of place to the Aboriginal peoples. The most useful theoretical approaches for studies on the Australian Aboriginal conceptions of place are: Place as a living entity, an ancestor and an extension of itself; place as movement, transformation and continuity; place as connection, existential orientation and the paramount focus, and; place as the very foundation of the entire religion.
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Verones, Valérie. "Conception, synthèse et évaluations pharmacologiques de nouveaux perturbateurs du fuseau mitotique". Phd thesis, Université du Droit et de la Santé - Lille II, 2011. http://tel.archives-ouvertes.fr/tel-00658236.
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Le cancer est l'une des principales causes de mortalité en France, après les maladies cardiovasculaires. Il est responsable de plus de 11 millions de décès dans le monde chaque année. Le cancer résulte d'une prolifération anarchique de cellules qui mène à la formation d'une tumeur. Les cellules tumorales peuvent ensuite migrer vers d'autres tissus pour former des métastases. La chimiothérapie est l'un des traitements les plus utilisés pour traiter le cancer. Elle consiste en l'utilisation d'agents antitumoraux qui provoquent la mort cellulaire en bloquant la mitose. Dans le but d'induire cette apoptose, nous nous sommes intéressés aux poisons du fuseau mitotique, agents cytotoxiques qui ont pour cible les microtubules et qui ont la particularité de se fixer sur leur constituant majeur, la tubuline. La dynamique des microtubules joue un rôle crucial dans la multiplication cellulaire. Bloquer cette dynamique est suffisant pour bloquer la mitose. Par ailleurs, suite à cet arrêt de la polymérisation, un second mécanisme se mettrait en place, notamment au niveau des cellules endothéliales, pour empêcher la néovascularisation, ce qui inhiberait ainsi l'angiogénèse. Notre travail consiste en la conception et la synthèse de nouveaux inhibiteurs de la polymérisation de la tubuline, potentiellement anti-angiogéniques et anti-vasculaires. Il s'agit de tricycles, qui ont la particularité d'interagir spécifiquement avec le site de fixation de la colchicine, au niveau de la tubuline, ce qui inhibe la polymérisation des microtubules et par conséquent la division cellulaire. Des tests d'inhibition enzymatique et de cytotoxicité sur plusieurs lignées cellulaires cancéreuses ont été réalisés et les résultats sont présentés dans ce rapport.
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Maherally, Uzma Nooreen. "Development and Validation of the Life Sciences Assessment: A Measure of Preschool Children's Conceptions of Basic Life Sciences". University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1396533078.
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Cauchois, Olivier. "Conception, Préparation & Caractérisation de Nanoparticules de Formes Complexes. Etude de leur Devenir In Vivo". Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00659379.
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La vectorisation est une stratégie pharmaceutique qui consiste non seulement à réduire les quantités de principe actif administrées, mais aussi à améliorer le rapport bénéfice/risque pour le patient. La délivrance cellulaire spécifique est augmentée alors que les effets secondaires causés par la délivrance non spécifique sont diminués. Pour être le plus efficace possible, différents vecteurs ont été proposés, non seulement capables d'encapsuler des molécules thérapeutiques, mais aussi d'interagir efficacement avec les cellules cibles. De ce point de vue, les nanoparticules polymères sont des objets intéressants pour cibler de manière spécifique certaines cellules, grâce à la combinaison unique d'une taille nanométrique et de la possibilité de moduler considérablement leurs propriétés physico-chimiques.A ce jour, l'influence de la morphologie des micro- et nanoparticules sur leur biodistribution est quasiment inconnue. Cependant, les rares études sur ce sujet suggèrent que la forme des objets introduits dans le corps a une influence majeure sur leur devenir dans les fluides [1], in vitro [2], et in vivo. Ainsi, l'observation des micro-organismes a déjà démontré que leur forme influence non seulement leur déplacement, mais aussi leur capacité à interagir avec les cellules et à être capturés par les macrophages.Comprendre, au niveau micro- et nanométrique l'influence de la forme sur les interactions entre les particules et les cellules présente un intérêt scientifique et pharmaceutique indéniable. Dans ce cadre, l'objectif de notre projet était d'identifier les différents mécanismes ou phénomènes que la forme peut impacter, et d'essayer de quantifier leur importance respective. De plus en plus d'études sur la fabrication de micro- et nanoparticules de formes originales émergent, mais quasiment aucune donnée ne fournit d'indication sur l'influence de la forme sur le comportement de ces objets.Pour mener à bien ce travail, nous nous sommes concentrés sur la production de particules non sphériques de formes et surfaces contrôlées, soit par une méthode d'auto-assemblage de copolymères de poly(gamma-benzyle-L-glutamate), soit par la déformation de particules sphériques. Enfin nous avons étudié l'influence in vitro de la forme sur les interactions avec des surfaces caractérisées, par résonance plasmonique de surface, sur les interactions avec des cellules (Cellules endothéliales humaines du cordon ombilical, HUVEC), et l'influence de la forme sur le devenir in vivo de ces particules. Tous ces éléments ont permis de démontrer que la forme des micro- et nanoparticules doit être considérée comme un facteur majeur pour moduler leur devenir in vivo.
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Lemoine, Hugues. "Les sécoiridoïdes d'Olea europaea et du Lonicera tatarica : matières premières destinées à la conception de nouveaux synthons chiraux pour la synthèse de composés biologiquement actifs et outils pour le développement de nouvelles méthodes d'extraction et de synthèse". Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00923156.
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Les sécoiridoïdes sont des monoterpènes hautement fonctionnalisés utilisés comme matières premières chirales renouvelables en hémisynthèse, lorsqu'ils sont abondants au sein des végétaux. Un nouveau procédé vert d'extraction aqueuse et de purification utilisant des résines et la chromatographie de partage centrifuge a permis l'isolement de plus de 100 g d'oleuropéine des feuilles d'Olea europaea et d'une douzaine de grammes de sécologanoside et de sweroside des feuilles de Lonicera tatarica. L'ouverture de la lactone du perpivaloylsweroside a été effectuée en milieu organique apolaire par le TMSONa. Cette réaction a été étendue à 8 lactones commerciales et 5 lactones de sécoiridoïdes. Une approche mécanistique de cette nouvelle réaction a été établie sur la γ-butyrolactone à l'aide d'une étude cinétique. Cette réaction a été utilisée pour la conversion du sweroside en sécologanoside en quatre étapes. Cette approche séquentielle a été appliquée avec succès sur les dérivés du sweroside. Quatre nouveaux analogues du sécologanoside et 9 synthons chiraux originaux ont ainsi été isolés. De plus l'étude de la réactivité de l'oleuropéine a permis l'obtention de 4 nouveaux synthons et un analogue isomérique du sécologanoside. Ces analogues de sécologanoside sont précurseurs de nouveaux alcaloïdes indolo-monoterpèniques. Enfin la double liaison exocyclique du sweroside a pu être sélectivement ozonolysée et épimérisée pour conduire à la formation d'un synthon clé pour la synthèse de diterpènes cytotoxiques marins de types xénicanes.
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Hewner, Michael. "Student conceptions about the field of computer science". Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45890.
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Computer Science is a complex field, and even experts do not always agree how the field should be defined. Though a moderate amount is known about how precollege students think about the field of CS, less is known about how CS majors' conceptions of the field develop during the undergraduate curriculum. Given the difficulty of understanding CS, how do students make educational decisions like what electives or specializations to pursue?
This work presents a theory of student conceptions of CS, based on 37 interviews with students and student advisers and analyzed with a grounded theory approach. Students tend to have one of three main views about CS: CS as an academic discipline focused on the mathematical study of algorithms, CS as mostly about programming but also incorporating supporting subfields, and CS as a broad discipline with many different (programming and non-programming) subfields. I have also developed and piloted a survey instrument to determine how prevalent each kind of conception is in the undergraduate population.
I also present a theory of student educational decisions in CS. Students do not usually have specific educational goals in CS and instead take an exploratory approach to their classes. Particularly enjoyable or unenjoyable classes cause them to narrow their educational focus. As a result, students do not reason very deeply about the CS content of their classes when they make educational decisions.
This work makes three main contributions: the theory of student conceptions, the theory of student educational decisions, and the preliminary survey instrument for evaluating student conceptions. This work has applications in CS curriculum design as well as for future research in the CS education community.
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Thomas, Christie Jane. "Conceptions of curriculum and classroom practice : an ethnographic study of family life education teachers". Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/31098.
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This ethnographic field study examined six female home economics teachers' conceptions of Family Life Education (FLE) curriculum, the perceived influences on these conceptions and the relationship of the conceptions to classroom practice. Data from classroom observations, interviews and selected documents were analyzed using a framework of conceptual categories from the literature of curriculum and of FLE, and two emergent analytic categories ("tensions and constraints" and "images of FLE curriculum practice").
Six curriculum conceptions were labelled according to the teachers' beliefs about the aims and purposes of FLE. Similarities were related to the nature of FLE subject matter, while differences suggested differing views of the educational enterprise. Although the teachers indicated that multiple factors had influenced their beliefs about FLE curriculum, all considered life experiences to have had the greatest impact, suggesting that the curriculum conceptions were personally derived and represent the teachers' personal visions of FLE curriculum.
The considerable consistency between the teachers' articulated beliefs and their classroom practice in this study implies that curriculum conceptions were significant influences on curriculum practice and confirms the belief in the field that the teacher is the FLE curriculum. Contextual factors (such as the institutional nature of schooling) appeared to mediate some beliefs and may have contributed to some inconsistencies between beliefs and practice and to the emergence of some unarticulated beliefs. For the most part, these factors were related to the subject matter itself and indicate that FLE teachers may experience some unique influences on their practice.
The images of curriculum practice provide insight into the role of beliefs in the translation of FLE curriculum in the classroom. Of particular significance was the extent to which these images reflected the influence of personal life experience. These images also situate teachers' beliefs about FLE curriculum within the classroom and indicate that teachers' beliefs interact with both the students and the subject matter of the curriculum. This interaction contributes to the character of the curriculum in use and suggests that while teachers' beliefs do play a central role in the translation of curriculum, other factors may also exert an influence.Education, Faculty of
Curriculum and Pedagogy (EDCP), Department of
Graduate
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Lindqvist, Gunilla. "Informal caregivers' conceptions of daily life with a spouse having chronic obstructive pulmonary disease". Doctoral thesis, Linnéuniversitetet, Institutionen för hälso- och vårdvetenskap, HV, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-23308.
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The overall aim of this thesis was to explore informal caregivers’ daily life with particular focus on those living with a spouse who has Chronic Obstructive Pulmonary Disease (COPD) in different grades, mild to severe, based on the ill person’s main concern. The study design was explorative, comparative and descriptive. The thesis included a literature review of 45 scientific articles and semi-structured interviews with 23 patients suffering from COPD, and 21 women and 19 men living with a spouse suffering from COPD. Data were analysed using content analysis, grounded theory, and phenomenography. Main findings: Men and women living with a spouse suffering from mild COPD did not experience changes in their daily life, and were not in need of support. It was when the COPD gradually escalated that their daily life was affected and they needed support. The caregiving women conceived that their daily life was socially restricted, they had changed roles, changes in health and changes in the couple’s relationship. The caregiving men’s daily life was conceived as burdened, restricted and the partner relationship was affected. The men’s attitude was to continue with their own life and own activities, and their approach to their caregiving situation was to view themselves as “Me and my spouse”. The main concern for people suffering from COPD was feelings of guilt due to self-inflicted disease associated with smoking habits. The thesis shows that there are differences in informal caregiving between males and females. Conclusion: This thesis shows that there are differences in male and female caregiving for a spouse suffering from COPD. The caregivers conceive and handle the caregiving situation in different ways. It is central that health professionals and municipality consider this along with the individual needs that are related to the development of the COPD. There is a need to identify the person who suffers from COPD and their spouses from the first contact onwards, to regularly follow the development of their situation and need of support.
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Hashemi, Dana. "The role vitamins in human life". Thesis, Київський національний університет технологій та дизайну, 2019. https://er.knutd.edu.ua/handle/123456789/13181.
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Rudyk, Y. I., i S. V. Solyonyj. "IoT components integration into human life". Thesis, Київський національний університет технологій та дизайну, 2021. https://er.knutd.edu.ua/handle/123456789/19356.
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Кобякова, Ірина Карпівна, Ирина Карповна Кобякова, Iryna Karpivna Kobiakova i V. V. Stepanov. "Modeling the human life frame concept". Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64767.
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Cognitive linguistics is a linguistic branch that considers ways of collecting, keeping and using verbalized knowledge. It is a science about language itself as well as about a reflected world picture. In its broadest meaning, world picture is regarded as a knowledge set about reality that was generated by public, group or individual consciousness. World pictures are divided into objective-reality, cognitive and linguistic pictures.
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Caron, Joachim. "Conception de nouveaux bioconjugués "squalénisés" anticancéreux dotés de propriétés d'auto-assemblage : synthèse, caractérisation des nanoparticules et évaluation biologique". Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00819390.
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La squalénisation est une méthode de vectorisation sous forme nanoparticulaire qui consiste àcoupler de manière covalente un dérivé du squalène à des principes actifs hydrophiles tels que lesanalogues nucléosidiques. Les conjugués amphiphiles obtenus sont capables de s'auto-organiserspontanément dans l'eau en nanoparticules d'une centaine de nanomètres de diamètre etpossèdent des activités anticancéreuses ou antivirales remarquables. Notre objectif était d'étendrecette stratégie à différentes classes d'antitumoraux, comme les antimétabolites, les antimitotiqueset les agents alkylants. Différents dérivés du squalène ont ainsi été synthétisés puis couplés à cesprincipes actifs pour former les bioconjugués squalénisés correspondants. Il a été montré que cesprodrogues étaient capables de s'auto-assembler en nanoparticules spontanément en milieuaqueux, que le principe actif soit hydrophile ou hydrophobe. Les suspensions nanoparticulaires deces prodrogues se sont montrées actives in vitro sur différentes lignées cellulaires cancéreuseshumaines et murines et in vivo chez la Souris sur des modèles de cancer. La squalénisation a donc étéétendue à diverses familles de composés anticancéreux confirmant qu'il s'agit d'une méthodegénérale de vectorisation pourvue d'un fort potentiel thérapeutique.
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Nugent, John Christopher. "Non-earthly conceptions of future hope in the Old Testament and Second Temple Jewish literature". Online full text .pdf document, available to Fuller patrons only, 2000. http://www.tren.com.
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Camara, Fatoumata. "Retours d'expérience sur la conception centrée valeur de Cocoon : vers des arbres de vie". Phd thesis, Université de Grenoble, 2012. http://tel.archives-ouvertes.fr/tel-00848189.
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Cette thèse porte sur la Conception Centrée Valeur (CCV) proposé par Gilbert Cockton dans le but d'aller au-delà de l'utilisabilité dans les systèmes interactifs. L'auteur propose un canevas pour la mise en oeuvre de la CCV. Cependant, les opérationnalisations restent partielles et sont réalisées par lui-même, d'où un manque de recul de la communauté vis-à-vis de la méthode. La thèse relate la conception centrée valeur de Cocoon, un système d'information mobile et sensible au contexte. Elle apporte des contributions à la fois sur les plans conceptuel et méthodologique. D'un point de vue conceptuel, elle introduit la taxonomie PIPE (Personnelle, Impersonnelle, Pérenne, Éphémère) pour la caractérisation de l'information. En outre, elle montre que les systèmes existants ne couvrent pas PIPE : ils sont surtout focalisés sur les informations impersonnelles. Alors, la thèse propose le concept d'arbre de vie et Cocoon. D'un point de vue méthodologique, la thèse apporte une compréhension meilleure de la notion de valeur. En outre, elle fournit un retour d'expérience sur la CCV accompagné de remarques et recommandations pour des mises en oeuvres futures plus performantes. Enfin, elle propose un canevas pour la construction des cartes de valeur et une stratégie pour l'estimation de la valeur.
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Abramovych, G. V., S. А. Ryndin i Г. В. Абрамович. "Implementation of artificial intelligence in human life". Thesis, ВНТУ, 2019. http://ir.lib.vntu.edu.ua//handle/123456789/24131.
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The article considers the advantages and disadvantages of using artificial intelligence in human life. The risks of its usage and thoughts of prominent developers are presented.В статті розглянуто переваги і недоліки використання штучного інтелекту у житті людини. Наводяться ризики його використання та думки відомих розробників.
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Leker, Laura. "Human Capital, Life Expectancy, and Economie Development". Paris, EHESS, 2015. http://www.theses.fr/2015EHES0127.
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Dans un article de 1967, Ben-Porath a mis en évidence qu'un allongement de l'espérance de vie rendait plus rentable l'investissement en éducation. Cependant, la validité empirique de ce mécanisme au niveau macroéconomique est contestée. Le chapitre introductif de la thèse propose une revue de la littérature et discute les difficultés rencontrées pour définir une stratégie empirique pour tester l'effet Ben-Porath. La thèse apporte une contribution théorique en proposant des modélisations de l'effet Ben-Porath dont les simulations donnent une magnitude réaliste. Le chapitre 2 développe un modèle OLG dans lequel la décision d'éducation est prise selon un marchandage intergénérationnel, contrairement aux modèles existants qui supposent que la décision d'éducation revient soit entièrement au parent, soit entièrement à l'enfant. L'introduction d'un tel marchandage influe sur la dynamique de long-terme de l'économie, en particulier sur la probabilité qu'il existe une trappe à pauvreté ou une zone de croissance perpétuelle. Le chapitre 3 développe un modèle de décision d'éducation avec rendements minceriens et horizon de vie incertain. Une simulation du modèle donne une fourchette de la magnitude attendue de l'effet Ben-Porath : un gain d'une année d'espérance de vie incite à investir 0. 25 à 0. 4 années d'éducation supplémentaires. La thèse apporte également une contribution empirique en évaluant l'effet Ben-Porath sur un panel de pays de 1900 à 1980 (chapitre 3), et sur un panel de départements français sur la 2nde moitié du XIXème siècle (chapitre 4). Les résultats donnent tous un coefficient de Ben-Porath entre 0. 15 et 0. 4, ce qui correspond à l'effet théorique attendu d'après la simulation du modèle du chapitre 3.
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Wada, Mineko. "Balance in everyday life : conceptions of men and women in dual-income couples with young children". Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/42819.
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BACKGROUND: As the social justice movement has lessened the gender gap in occupational participation, the subject of balance in life is receiving enormous attention. A growing body of literature suggests that imbalance can increase individual’s health risks. Although various theories about balance have been developed, it remains elusive as a concept. Understanding how people experience and perceive balance is essential to conceptualizing balance and promoting individual and societal health. OBJECTIVE: To better understand the ways in which men and women in dual-income couples with at least one preschool-aged child perceive and experience balance in everyday life. METHODS: The study was primarily informed by a phenomenographic approach. Fifteen heterosexual, dual-income couples living with at least one child under six years old were recruited from a metropolitan area. Each partner in each couple individually participated in two semi-structured interviews. The first interview was designed to explore participants’ overall experiences of daily life, while the second interview aimed to elicit their experiences and perceptions of balance. Phenomenographic and critical discourse analyses were applied to the interview data. The quality of the findings was assured by peer-debriefing, reflexivity, and the verification of transferability. RESULTS: Two key conceptions of balance were identified: managing life and participating in a mix of occupations. In elucidating these conceptions, parents associated the former with meeting collective needs and the latter with meeting individual needs. Trying to simultaneously satisfy these two conceptions/constructions of balance created tension. Managing life reinforced parents’ intensive commitment to parenting and led to balance, but it limited their engagement in personal occupations, which led to imbalance. Conversely, participating in a mix of occupations allowed parents to meet their own needs and was associated with balance, but as it reduced the time they spent with their families, it led to imbalance. CONCLUSION: Employed parents with young children live with two competing conceptions/constructions of balance, which can create tension and affect health. Developing health care and employment policies that help parents to attain a greater sense of balance by harmonizing collective needs of the family and their personal needs may mediate this tension.
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Silvestru, Alexandra. "Decolonizing Ecology: How Do Indigenous Knowledge and Decolonization Contrast and Challenge Eurocentric Conceptions of Ecological Moral Worth?" Thesis, Högskolan Dalarna, Religionsvetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:du-35297.
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In a world on the brink of climate apocalypse the question if modern conceptions on the moral worth of nature are failing is no longer rhetorical. During this time of reckoning questioning core ideologies and the places where they originate from is necessary. In matters of ecology, Eurocentric colonial paradigms dominate the scientific and philosophical narrative. Increasing in reach and exposure, Indigenous people and the environmental movements they support, point to a coherent body of knowledge which teaches humans how to live in better relationship to the natural world. This inquiry will be comparing, contrasting, re-evaluating these radically different worldviews and value sets, while seeking to understand the differences between Indigenous knowledge and Eurocentric environmental ethics. The tool with which this will be attempted is decolonization, chosen for its radical questioning of the entrenched colonial and Eurocentric status quo. Perhaps by showing how Indigenous knowledge challenges and contrasts the dominant ecological culture, it can then guide and inform Eurocentric environmental ethics toward a new ecological epistemology and the work of decolonizing ecology can begin in earnest.
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Hungr, Nikolai. "Conception et évaluation de systèmes robotiques de ponction d'aguilles percutanées sous contrôle d'imagerie médicale". Phd thesis, Université de Grenoble, 2014. http://tel.archives-ouvertes.fr/tel-00997017.
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Cette thèse décrit la conception et l'évaluation de systèmes robotiques de ponctions percutanées d'aiguilles guidés par imagerie médicale. Les ponctions percutanées d'aiguilles sont devenues de plus en plus communs dans la diagnostique et le traitement d'un assortiment de maladies humaines. Des exemples d'interventions fréquentes sont les biopsies, les ablations de tumeurs par radiofréquence, la cryothérapie, le drainage et la curiethérapie, entre autres. Le couplage de l'imagerie médicale avec l'insertion d'une aiguille donne suite à un nombre de difficultés pour le clinicien, tels que l'alignement précis de l'aiguille à la trajectoire planifiée dans l'image, la réalisation de trajectoires complexes et hors-plans difficiles à visualiser, et la compensation du mouvement et déformation des tissus mous. La robotique peut être utilisé pour assister à ces procédures pour simplifier les défis et potentiellement améliorer leur précision, leur bénéfices cliniques et leurs taux d'inclusion. Cette thèse expose les défis techniques et cliniques auxquels il faut faire typiquement face pendant la conception et l'évaluation de tels robots de ponction, tout en restant sur les aspects qui les différentient d'autres robots médicaux. Une revue de l'état de l'art est utilisé pour décrire ces défis et pour présenter les divers solutions déjà proposés pour leur faire face. Sur cette base, deux tels systèmes robotiques, développés pendant cette thèse, sont décrits en détail, donnant ainsi des exemples concrètes des nombreuses contraintes imposés dans le cadre de ponctions d'aiguilles guidés par imagerie médicale. Le premier système, s'appelant PROSPER, est dédié aux interventions prostatiques transpérinéales guidés par imagerie ultrasonique, en particulier la curiethérapie. Le robot est fixé à la table chirurgicale et une sonde échographique 3D transrectale lui est rigidement relié, permettant ainsi un calibrage préopératoire entre l'espace du robot et l'espace image. Le protocole développé pour ce système inclue un recalage écho-écho peropératoire pour compenser le mouvement et la déformation de la prostate pendant l'insertion des aiguilles. Ce chapitre expose les défis d'un système qui n'est pas physiquement présent dans l'espace de l'image et qui tient en compte le divers contraintes intrinsèques à l'environnement des tissus mous. Le deuxième système s'appelle LPR et est destiné à la radiologie interventionnelle des régions thoraciques et abdominopelviennes, sous guidage TDM et IRM. Il est fixé sur le corps du patient et positionne et insère une aiguille selon une trajectoire et visant une cible choisis par le radiologue dans l'image. Le robot est calibré à l'image en peropératoire par moyens de mires multimodales incorporés dans la structure du robot. Il est entièrement compatible avec les deux modalités d'imagerie en terme de qualité d'image et contraintes de taille. Par rapport au robot PROSPER, ce chapitre montre comment la présence du robot dans l'espace de l'image donne suite à un nombre d'autres défis qui doivent être considérés pour permettre son acceptabilité clinique. Dans les descriptions des deux systèmes, l'accent est mis sur les solutions innovantes mises en place dans le but de fournir des vrais bénéfices cliniques aux patients ainsi qu'aux cliniciens. Des prototypes de chaque système ont été développés et évalués sur des fantômes synthétiques en termes de leur précision et compatibilité préclinique.
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Harrison, Makiko Ito. "The human development index : a search for a measure of human values". Thesis, London School of Economics and Political Science (University of London), 2001. http://etheses.lse.ac.uk/2499/.
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The thesis investigates methods of evaluating indexes that measure concepts of human values. My understanding of indexes, especially on how they relate to the real world and concepts (that are the objectives of the measurement), is influenced by my study of literature on models used in economic and in physics. We learn from this study of models the following: (1) regularities described in theories do not represent real world phenomena, which consist of many different forces acting simultaneously; (2) but such regularities are true in models, because they describe specific conditions under which regularities in nature are displayed; (3) there are more than one model that can represent the same phenomenon depending on which particular aspect of the phenomenon to focus on; and (4) the success of a model has to be evaluated partly by criteria that are independent from theoretical ones. Since the role indexes play in relation to real world and concepts are similar to the role models play in relation to theories, I have applied the above knowledge to propose the following three criteria to evaluate successful indexes: (1) Purpose-dependent criteria: criteria that are based on particular motivations of the measurement project; (2) Theory-dependent criteria: criteria that are reflected in the theories that expressly or implicitly guide the development of the project of measurement; and (3) Conditions-dependent criteria: criteria that are based on the conditions under which the index measures what it is designed to measure. I apply these three criteria of successful indexes to examine two projects of measuring human values, one called the Human Development Index developed by the United Nations Development Programme and the other called the Life Satisfaction Indicator developed by an officer at the Economic Planning Agency in Japan. Among the findings from the examination of those two indexes are that they can be the products of a mixture of concerns that include convenience, conventions, practicality, politics and consistency with relevant theories, and some of these concerns may conflict with each other. Another important finding is that because there are many assumptions made and simplifications applied in order to choose a quantitative representation of a human value, the application of the measure is limited. I conclude that both in using and in evaluating indexes of human values, it is important that we are aware of such limitations, so that we can more effectively know both how to avoid misusing the indexes and how to improve them over time.
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Farrant, Anthony James. "An ethical consideration of increasing human life spans". Thesis, University of Hull, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422037.
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Gavryliuk, O. I. "Aromatic heterocycles and their significance in human life". Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18680.
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Sefcek, Jon Adam. "A Life-History Model of Human Fitness Indicators". Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194693.
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Recent adaptationist accounts of human mental and physical health have reinvigorated the debate over the evolution of human intelligence. In the tradition of strong inference the current study was developed to determine which hypothesis; Rushton’s (2000) differential K theory, or Miller’s (2000a) fitness indicator model (F), better accounts for general intelligence ('g') in an undergraduate university population (N = 194). Due to the lengthy administration time of the test materials a newly developed 18-item short form of the Ravens Advanced Progressive Matrices (APM-18; Sefcek, Miller, & Figueredo, 2007) was used. There was a significant positive relationship between K and F (r = .31, p < .001), however no significant relationships were found between 'g' and either K or F (for each, r = -.06, p ≥ .05). While contrary to both hypotheses, these results may be explained in relation to antagonistic pleiotropy and a potential failure to derive within species comparisons directly from between species comparisons.
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Larsen, Moen Øyfrid. "Everyday life in families with a child with ADHD and public health nurses’ conceptions of their role". Doctoral thesis, Karlstads universitet, Institutionen för hälsovetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-30940.
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ADHD is one of the most common behavioral disorders diagnosed in children. These children have difficulties regarding the regulation of emotions, maintaining attention and impulse control, all of which influence family and social life. The aim of this study was to describe and explore the everyday life of families with a child with ADHD and public health nurses’ role in relation to these families. The parents were contending with- and adapting to the parental role and social network. The family attempted to safeguard a functioning family in managing their everyday life, tuning themselves in on the child’s shifting moods, using strict boundaries and developing special skills. The family fought for acceptance and inclusion when interacting with their social network and professionals. Parents with ADHD and families with non-medicated children reported more problems in family functioning. Characteristics in parents and the child with ADHD, as well as support from the social network and community health services, all influenced family functioning. The PHNs described their role as both a peripheral and collaborating partner, asking for guidelines and multidisciplinary collaboration. The public health nurse is in a unique position to support and supervise these families.Aim: The overall aim of this thesis was to describe and explore everyday life in families with a child with ADHD and public health nurses’ role in relation to these families. Methods: An explorative and descriptive design with qualitative and quantitative methods was used. In Study I, data was collected with individual interviews with nine parents, and analyzed using phenomenology. In Study II, the data was collected with individual interviews with 17 family members, and analyzed with phenomenography. In Study III, data was collected with a questionnaire responded by 265 parents, and analyzed with statistics. In Study IV, data was collected with group- and individual interviews with 19 public health nurses, and analyzed with phenomenography. Main findings: The families’ everyday life was influenced by living in unpredictability, though they were striving for predictability. The experience of being a parent was described as contending and adapting every day, like windsurfing in unpredictable waters (I). The family tried to safeguard a functioning family in managing their everyday life and developing special skills, within the family and the society. They fought for acceptance and inclusion in relation to the social network and professionals (II). Parents’ sense of coherence, children’s behavior, support from social networks and community health services had all an impact on family functioning (III). The PHNs described their role as both a peripheral and a collaborating partner and they asked for guidelines and multidisciplinary collaboration (IV). Conclusions: Everyday life in families with ADHD is both demanding and giving. Acceptance and support from the social network and supervision from the professionals are essential. The public health nurse is in a unique position to support and supervise these families.
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Shushan, Gregory. "Universalism and culture-specificity in conceptions of the afterlife in early civilisations and near-death experience". Thesis, University of Wales Trinity Saint David, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.683275.
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Klimecki, Haley M. "Expression of Human Neutrophil Elastase in K. Lactis". Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/honors/2.
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Human neutrophils are the most abundant type of white blood cell and provide the body with a line of defense against foreign, infectious microorganisms. Contained within the azurophilic granules in the cytoplasm of neutrophils are three serine proteases, Human Neutrophil Elastase, Cathepsin G, and Protease 3. Once a foreign bacterium is engulfed by white blood cells, these enzymes attack and degrade the invading body, thus killing it (Reeves et al., 2002). The focus of this research is centered on the production of one of the serine proteases, human neutrophil elastase (HNE), and while the importance of HNE can be seen, genetic mutations or improper regulation can compromise a person’s immunity. Neutropenia (a low neutrophil count) is one such disease caused by a genetic mutation of HNE that results in susceptibility to infection (Li and Horwitz, 2001). Additionally, HNE is a powerful enzyme that can attack the elastin of the lung if not properly controlled. Consequently, genetic deficiencies of alpha-1 proteinase inhibitor protein in the blood can result in emphysema because active HNE released from neutrophils is free to degrade lung tissue (Laurell and Eriksson, 1965).
Recombinant HNE is not currently available, and the enzyme must be isolated from human blood cells, which has inherent hazards. Additionally, the lack of recombinant HNE has prevented studies involving site–directed mutagenesis to study the intracellular processing of HNE near its C-terminal end where mutations have been found to result in neutropenia. Kinetic studies of the full-length HNE might shed some light on why its C-terminal region is removed before storage in cytoplasmic granules.
The HNE DNA sequence was first codon optimized for yeast and commercially synthesized. It was then fused with DNA for eGFP (enhanced green fluorescent protein) via an enterokinase cleavage site (D4K). This DNA construct (eGFP-D4K-HNE) was then inserted into the Kluyveromyces lactis (K. lactis) pKLAC1 vector, downstream of the alpha mating factor which directs proteins for secretion. Then, chemically competent GG799 cells (a strain of K. lactis) were transformed with the linearized pKLAC1-eGFP-D4K-HNE insert through a protocol from New England Biolabs. Theoretically, the gene integrates into the yeast genome upon transformation via sequences within the pKLAC1 vector that are homologous with the LAC4 gene promoter that allows for galactose utilization (Colussi 2005). Acetamide was used as a selectable marker because wild type K. lactis cells are not able to use acetamide as a nitrogen source. The pKLAC1 vector, however, contains the Aspergillus nidulans gene acetamidase (amdS) that allows only transformants to grow on plates with acetamide as the sole nitrogen source (Read 2007).
Selected colonies were transferred to both liquid and agar-based synthetic media with galactose to induce transcription and translation of the HNE gene to produce the eGFP-D4K-HNE fusion, and screened via fluorescence microscopy for production of eGFP. None of the screened colonies tested positive for the presence of the fusion protein.
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Левковець, Олег Григорович, Олег Григорьевич Левковец i Oleh Hryhorovych Levkovets. "Physical education, as a social phenomenon in human life". Thesis, Sumy State University, 2015. http://essuir.sumdu.edu.ua/handle/123456789/48637.
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Physical education - the kind of culture of the society and people. This activity and its results from the formation of physical readiness for life; on the one hand, the specific process, on the other - the result of human activity, and the means and manner of physical perfection people. In relation to culture a person acts in three ways: it develops its (consumption) is the carrier of culture and creating new cultural values. The development of "consumption" physical culture manifested in the results of this activity – in mastering knowledge of physical properties and motor abilities, "owner" of which he is [1, 3].
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Cockerman, S., Cecil Blankenship, Teresa Brooks Taylor, Jamie Branam Kridler i Mary R. Langenbrunner. "Life After College: What Do Human Services Graduates Say?" Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/3477.
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Gleeson, Margaret McDonnell. "Language learning and life processes /". View thesis View thesis, 1997. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030514.092005/index.html.
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Thesis (M. Sc. of Soc. Ecology (Hons.))--University of Western Sydney, Hawkesbury, 1997."Submitted as partial requirement for Master of Science (Hons.) Social Ecology, University of Western Sydney, Hawkesbury, 1997." Includes bibliographical references (p. 165-170).
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Bernard, Julia M., Amber Seidel, Mary Oglesby i Colleen Pagnan. "Mothers in HDFS Academic Life: When Your Professional Life and Real Life Intertwine". Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/5808.
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Martin, Vivienne. "A narrative inquiry into the effects of serious illness and major surgery on conceptions of self and life story". Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495891.
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Coope, Jonathan. "Pathologizing modernity : critical implications of the conceptions of 'pathology' and 'higher sanity' in the works of Theodore Roszak and Ken Wilber". Thesis, University of Chichester, 2008. http://eprints.chi.ac.uk/826/.
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In this thesis I argue that 'critical theorists', and the left in general, have paid insufficient attention to the psychological and pathological dimensions of the problems of modernity, including its environmental predicaments. To address this theoretical lacuna, I critically examine the conceptions of 'collective pathology' and 'higher sanity' as articulated in the relatively neglected work of Theodore Roszak and Ken Wilber, my position being that these two thinkers offer the most sophisticated readings of modernity and its 'ecological crises' in terms of pathology currently available. I also demonstrate a number of crucially significant implications of their work for contemporary critical theory. Consequently, the thesis is organized in two parts: in Part One I examine the work of Roszak and Wilber; in Part Two I explore major, critical implications of their work. The thesis begins with a critical examination of the concepts of 'pathology' and 'higher sanity' in Roszak and Wilber. I subsequently show how a critique in terms of these concepts alerts us to specific legimating tropes in ecocritical theory which have deligitimized competing discursive practices, and how such conceptions address and illuminate an ecological 'blind spot' in contemporary historical theorizing: no such study has been previously attempted. I then argue that conceptions of 'pathology' and 'higher sanity' indicate that debates between eco-centric notions of nature as 'real' and postmodernist notions of nature as a 'social construction' represent a double-bind; a false problem caused by specific unconscious and/or unacknowledged presuppositions. I go on to demonstrate how this double-bind can be overcome by, for example, exploring the psychology of Derridean deconstruction. In its examination of the critical implications of 'pathology' and 'higher sanity', this thesis can be read overall as a way of regrounding a radical ecological critique that is fully 'postmodem' - in the sense of aporetic - yet 'transcendent' at the same time. Consequently, this study is offered as an original resource for radical environmental activists who consider that the 'grounding' of their critique is undermined by postmodern and/or deconstructionist anti-foundationalism; I argue that such fears are 'groundless'.
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Defontaine, Antoine. "Modélisation multirésolution et multiformalisme de l'activité électrique cardiaque". Phd thesis, Université Rennes 1, 2006. http://tel.archives-ouvertes.fr/tel-00121024.
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Une méthode originale de modélisation de l'organe coeur complet basée sur une considération multirésolution et multiformalisme de l'activité électrique cardiaque est proposée.Les notions de cardiologie et d'électrophysiologie ainsi qu'une synthèse de modèles du système cardiovasculaire sont présentées dans la partie 1.
La partie 2 reprend les contributions du travail qui concernent:
– la proposition d'un cadre formel à la modélisation prenant en compte les exigences de la multirésolution et une volonté de structuration des outils utilisés pour une meilleure portabilité;
– la proposition d'une librairie générique de modélisation et simulation multiformalisme développée sous forme objet et permettant une définition standardisée des modèles et simulateurs;
– l'intérêt de la librairie est illustré sur des applications physiologiques et cliniques.
Un chapitre prospectif et présentant une réflexion pour une considération multirésolution clôt ce mémoire et ouvre des perspectives intéressantes.
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Schwartz, Sarah L. (Sarah Leah). "Owning the code of life : human gene patents in America". Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/101364.
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Thesis: S.M., Massachusetts Institute of Technology, Department of Comparative Media Studies, 2015.Cataloged from PDF version of thesis.
Includes bibliographical references (pages 49-54).
In 2013, the United States Supreme Court heard the case of Association of Molecular Pathology v. Myriad Genetics. The case asked one question: are human genes patentable? Gene patents became commonplace during the biotechnology revolution of the 1980s, but generated a complex web of moral, legal, and biological questions. While some viewed gene patents as necessary in promoting and sustaining innovation, others felt that owning the code of life was morally and legally misguided. This tension played a central role in the early years of the Human Genome Project, and continued as people experienced the challenging consequences of assigning property rights to our shared biology. Several patients with genetic diseases were forced to navigate limited or expensive testing because of a company's genetic monopoly. Some scientists worried that their research might infringe a patent. When the Supreme Court decided the Myriad trial, ruling that unaltered human genes were not patent-eligible, their decision marked a surprising and historic shift in the relationship between patent law and fundamental biology-but questions and uncertainty about a future without gene patents remain.
by Sarah L. Schwartz.
S.M.
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Borges, Carla Débora Gonçalves. "Interaction of human foraging behaviour and prey life-history traits". Master's thesis, Universidade de Aveiro, 2008. http://hdl.handle.net/10773/774.
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Mestrado em Ecologia, Biodiversidade e Gestão de EcossistemasO presente trabalho propõe-se divulgar a pesquisa passada e recente no âmbito das consequências da exploração de recursos costeiros pelo homem na biologia das espécies alvo e na comunidade onde estas estão inseridas. A ênfase das pesquisas aqui apresentadas recai principalmente sobre moluscos bentónicos e lapas em particular, dada a ocorrência de protandria (mudança de sexo de macho para fêmea ao longo do ciclo de vida) em algumas das espécies usadas como recurso alimentar. Questões relacionadas modos de reprodução, hermafroditismo e mudança de sexo no mundo animal são igualmente focadas como introdução aos últimos capítulos da dissertação onde se aborda essas questões mais profundamente. No capítulo final são apresentados trabalhos científicos que retratam a importância das áreas marinhas protegidas na conservação de espécies costeiras. ABSTRACT: The present work aims to bring to public, past and present research in the costal resources exploitation by Man and its consequences upon target species and the surrounding community. Particular attention is given to benthic molluscs and limpets in particular due to the occurrence of protandry (sex change from male to female during the life cycle) in some of the harvested species. The issues related to reproduction mode, hermaphroditism and sex change in animals are presented first as to introduce later chapters where these subjects are deepened. The final chapter presents relevant research of the use marine protected areas to the conservation of coastal species.
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Bourbeillon, Julie. "Vers une synthèse d'information orientée tâche - Application à la conception et l'évaluation de Tissue MicroArrays". Phd thesis, Université Joseph Fourier (Grenoble), 2007. http://tel.archives-ouvertes.fr/tel-00192285.
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Dans un contexte où des technologies et matériels nouveaux permettent un traitement en masse d'échantillons et où les données acquises sont de plus en plus partagées entre équipes de recherche, les scientifiques sont confrontés à un problème majeur d'exploitation de données. Plus précisément, utiliser ces données par des outils de fouille de données ou les replacer dans une démarche expérimentale classique nécessite une appréhension préalable de l'espace informationnel disponible afin de diriger le processus. Or cette appréhension de données est un problème complexe, peu supporté par les outils informatiques actuels. L'objectif de cette thèse est de proposer une solution à ce problème d'appréhension des données scientifiques. Illustrée dans le domaine applicatif des Tissue MicroArrays, la proposition se base sur la notion de synthèse, inspirée des paradigmes de Recherche d'Information. Le modèle de synthèse envisagé, qui donne un rôle central à l'étude que le chercheur veut mener, par la notion de tâche, permet l'opérationnalisation d'un concept de Recherche d'Information orientée tâche par un prototype. Le prototype mis en place est validé par des étude de cas et une étude utilisateurs et ouvre des perspectives intéressantes d'extension du modèle ou d'extension à d'autres domaines applicatifs.
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Wehrspaun, Claudia Constanze. "Transcriptional brain networks and their key regulators across the human lifespan". Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8f6e0ce4-86ea-4034-ad16-753edb7717de.
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The human brain’s transcriptome undergoes substantial changes over the lifespan and shows characteristic patterns that reflect anatomical regions and cellular compositions. In this thesis, I applied combinations of network algorithms and tools from computational biology to analyse transcriptional networks and their key regulators in the human brain across space (brain regions) and time (the human life course). First, I identified an age-dependent transcriptional network enriched for microglial markers. The microglia network recapitulated haematopoietic master regulators that are crucial for early microglia development using data from the ageing human brain only. In the second project, I demonstrated that gene clusters linked to neurogenesis during fetal life show moderate to strong preservation in the human adult brain. In addition to temporal development, I analysed transcriptional network dynamics across the spatial axis and detected a network of ion channel/transporter genes that express their longest 3’ untranslated regions (3’UTRs) exclusively in the brain. Enrichment for predicted miRNA response elements that are often shared among the ion channel/transporter genes, along with increased co-expression of this gene set, indicated that the extended 3’UTRs could serve as a hub for an endogenous competitive RNA network. I extended the analysis to differentiate between brain regions and additional regulatory RNA elements, namely long noncoding (lnc) RNAs. I found that genes in the hypothalamus express a region-specific network to which are also associated co-expressed lncRNAs. Finally, I added global metrics to the analysis of local networks. The dynamics of global network metrics indicated strong coordination of expression across the lifespan compared to similar variance within age groups. This work shows that the transcriptome of human post-mortem brains at least partially preserves the network structure of cell types and functionally related genes, and how it may be dissected using suitable combinations of bioinformatic algorithms.
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Mountain, Travis Patrick. "Life Insurance and Financial Vulnerability". The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1437387344.
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Mann, Michael Frank. "Students' Use Of Formal And Informal Knowledge About Energy And The Human Body". Thesis, Curtin University, 2003. http://hdl.handle.net/20.500.11937/1917.
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During the past three decades, much research has occurred into students' conceptions as well as factors influencing them and how the conceptions are formed. This study reports on students' conceptions involving energy and the human body. Initially, a number of student conceptions within the overarching area of energy and the human body were identified by developing and administering questionnaires to 610 students ranging from Year 8 through to Year 12. Students' responses to the questionnaire items resulted in previously identified conceptions as well as a number of unreported ones. The unreported notions included: carbohydrates are different to sugars; energy is needed for organs to function; fats and their role in energy storage; the eye and ear do not convert energy but transfer it to the brain; sweat cools the skin due to contact with air; objects need energy to start moving but not to move; and aspects of respiration and digestion. Conceptions such as the particulate nature of energy, energy's usefulness, conservation and transfer of energy, role of digestion and respiration, sources of energy were associated with previously identified notions which were derived from both informal and formal learning situations. But, it was not possible to distinguish which source knowledge was derived from. From these notions, a series of possible pathways for conceptual development within the area of energy and the human body were described. Further analysis of the data indicated a number of ontological changes that can occur as the student-cohort became older. These ontological changes included a decline in the notion of energy being particulate to being non-particulate and not being described, through to being involved in the chemical bonds of molecules, the role and processes of digestion, the number of energy types and energy sources and how the eye and ear function.All these conceptions changed with student age and became more scientifically acceptable in their nature as students' formal education increased. Based upon the findings of the above questionnaires, a diagnostic paper and pencil instrument set of 20 items based upon a modified two tier multiple-choice format was developed to identify student held conceptions on energy and the human body. Subsequently, an interventionist strategy was designed and implemented to help students avoid the development of misconceptions as they construct acceptable concepts related to digestion and to respiration. This strategy follows the passage of food from its ingestion through to the absorbed foods conversion into ATP for use by the body. The findings of this study are to be of use to science teachers worldwide, not only in Western Australia as the findings of this thesis are relevant to educators of students in Years 8 to 12. The findings are related to energy in general but specifically to the students' own body. These findings relate directly to an intrinsically interesting feature, the student's own body. Another outcome of these misconception findings are two instruments which are likely to be of value to educators of Years 8 to 12 students. These are a diagnostic instrument designed to identify a number of alternative conceptions learners may hold and secondly a lesson sequence dealing with digestion and respiration and the role these have in the conversion and transfer of energy in the body.
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Smart, Emily. "Expanding conceptions of privacy a comparative study of the European Court of Human Rights and the United States Supreme Court /". Connect to resource, 2009. http://hdl.handle.net/1811/37108.
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Paris, Christian. "The role of CTCF in the life cycle of human papillomavirus". Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/6367.
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Papillomaviruses (PV) are epithelium specific DNA viruses that can cause health problems ranging from harmless warts to invasive cancer. Papillomavirus induced tumours most often arise in the cervix where human papillomavirus (HPV) infections were shown to cause 99.7 % of all malignancies. This study aims to map binding sites of the multifunctional host protein CCCTC binding factor (CTCF) to the papillomavirus genome, validate them and determine the function of CTCF in the papillomavirus life cycle. Computer predictions of CTCF binding sites in the sequence of 8 different PV revealed a CTCF binding pattern including a conserved high-affinity binding site around nucleotide 3000 in high risk HPV and around nucleotide 5400 in low risk HPV. This binding pattern was experimentally confirmed using electrophoretic mobility shift assays (EMSA). The binding site around nucleotide 3000 in HPV18 was mutated and human foreskin keratinocytes (HFK) were transfected with mutant and wild type HPV18 to analyse the effect of the mutation on viral gene expression and life cycle. Western blotting of methylcellulose differentiated HFK revealed earlier expression of E2 and decreased expression of E1^E4 in the mutant compared to the wild type. Immunostaining of organotypic raft cultures grown from the mutant maintaining cells showed a significant increase in proliferating cells compared to the HFK maintaining the wild type. This was accompanied by pseudo-differentiation of keratinocytes since the cells of the granular layer of the raft expressed the terminal differentiation marker loricrin but maintained the morphology of undifferentiated cells. Thus CTCF was shown to have a major impact on the HPV life cycle and it may play a role in HPV induced carcinogenesis. Furthermore a function of CTCF in long term maintenance of the viral episome was revealed as cells maintaining the CTCF mutant were shown to lose episomes more quickly compared to wild type maintaining cells.
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Johnson, Leah R. "Mathematical modeling of cholera : from bacterial life histories to human epidemics /". Diss., Digital Dissertations Database. Restricted to UC campuses, 2006. http://uclibs.org/PID/11984.
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