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Rozprawy doktorskie na temat „COMT”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Gonçalves, Ana Margarida Ribeiro. "Isoformas da enzima catecol-O-metiltransferase como alvo farmacológico na doença de Parkinson." Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1636.

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Este trabalho encontra-se dividido em dois Capítulos. O Capítulo 1 aborda o estágio realizado em Farmácia Comunitária, na Farmácia Ferrer de Castelo Branco. Para além de serem descritas as instalações e a sua organização espacial, é apresentada a equipa técnica juntamente com suas funções e abordado de forma geral o sistema informático utilizado (Sifarma 2000). São ainda descritas as várias atividades realizadas durante o estágio, desde a elaboração de encomendas, receção e armazenamento, prestação de cuidados farmacêuticos, elaboração de medicamentos manipulados, dispensa de medicamentos suje

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Andersson, Anneli. "Katekol-O-Metyltransferas (COMT), tidigare övergrepp, gen-miljöinteraktion i förutsägelsen för våld." Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-42712.

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Flera kandidatgener har föreslagits spela en roll i utvecklingen av antisociala beteenden i samband med miljöfaktorer. Syftet med den föreliggande studien var därmed att undersöka sambandet mellan genen Katekol-O-Metyltransferas (COMT) och våld; och om det fanns interaktioner mellan exponering för tidigare övergrepp och COMT i samband med senare våld. Data hämtades från en Svensk populationsbaserad studie baserad på 2500 20-24 åringar. Den aktuella studien fann att beroende på vilken variant av genen man besitter, kommer man att påverkas i olika grad av negativa miljöfaktorer såsom försummelse

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CASTELLANO, FILIPPO. "Funzioni Esecutive e Facial Emotion Recognition in Persone Affette da Schizofrenia: ruolo del Polimorfismo del COMT e dell'Abuso di Alcol e Sostanze." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/94538.

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BACKGROUND: le caratteristiche cognitive e genetiche sono sempre più centrali nello studio della Schizofrenia. La compromissione delle Funzioni Esecutive (FE), definite come un complesso di abilità cognitive superiori attribuibili alle regioni della corteccia prefrontale, e della Facial Emotion Recognition (FER) rappresentano elementi centrali nel disturbo schizofrenico. Ad oggi, però, il paradigma del (dis)funzionamento cognitivo nella Schizofrenia poggia su studi che hanno escluso i soggetti schizofrenici con storia di abuso di sostanze (SUD), che ha mostrato un impatto peggiorativo sulla co

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4

da, Silva Costa Isis. "Variations in EEG and motor functions related to COMT gene in patients with fibromyalgia." Doctoral thesis, Universitat de les Illes Balears, 2017. http://hdl.handle.net/10803/399443.

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La fibromialgia (FM) es un síndrome crónico caracterizado por dolor generalizado, fatiga, sueño no reparador, quejas somáticas y alteraciones afectivas y cognitivas. Aunque existe evidencia reciente indicando que las emociones negativas pueden desempeñar un papel modulatorio relevante para el mantenimiento de los síntomas de la FM, poco se conoce de la influencia de los polimorfismos genéticos sobre la función motora, el sueño y el procesamiento afectivo en fibromialgia. El objetivo principal de esta tesis fue analizar la influencia del polimorfismo val158met del gen de la COMT, que se encuent

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Barbosa, Marta Cristina Fornelos. "Sistema Nervoso Central: planeamento químico-farmacológico para obtenção de um novo alvo terapêutico para a doença de Parkinson." Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3205.

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Trabalho apresentado à Universidade Fernando Pessoa como parte integrante dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>O presente trabalho pretende seguir uma linha de investigação pré-laboral, mas de enorme potencial devido à possibilidade de apresentar uma significativa redução nos custos aquando do lançamento de uma nova solução terapêutica. O trabalho será desenvolvido na área do sistema nervoso central (SNC) e a doença abordada será a doença de Parkinson. No decorrer deste trabalho irá ser feito uma abordagem ao tratamento farmacológico da DP, e realizado um

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6

Kawa, Kevin Hideyuki, and Kevin Hideyuki Kawa. "Genetic and Neuroanatomic Factors that Influence Executive Functions in Aging." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/622974.

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In the present set of experiments, we investigated the effects of age and COMT genotypes on traditional measures of executive functions, e.g., Wisconsin Card Sorting Test (WCST; Hart et al., 1988), a battery of executive functions based on the 3 factor model (shifting, updating, inhibition) described by Miyake et al. (2000) and developed at the University of Arizona (Alexander et al., 2012), and two fMRI tasks of executive functions (shifting, updating). The results of experiment 1 showed that COMT influenced performance on several traditional measures of executive functions, with Met homozyg

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7

Ho-Yue-Kuang, Séverine. "Exploration des voies de biosynthèse de l’acide férulique dans les grains et tiges de Brachypodium distachyon." Nantes, 2015. https://archive.bu.univ-nantes.fr/pollux/show/show?id=ed667b2c-bd04-465a-bea7-b1ae49162a58.

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L’acide férulique joue un rôle clé dans les parois cellulaires des Poaceae en permettant la réticulation des chaînes de polysaccharides entre elles et avec les lignines. La connaissance de sa biosynthèse peut améliorer l’usage des céréales en permettant de moduler les propriétés mécaniques des parois et leur digestibilité enzymatique. La plante modèle des Poaceae, Brachypodium distachyon, a été utilisée pour explorer les voies de synthèse de l’acide férulique. Une stratégie de génétique inverse a été mise en place afin d’étudier deux enzymes candidates, la COMT et la CCoAOMT sélectionnées pour

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8

Soares, Rui Filipe Lopes. "Biosynthesis of human membrane-bound Catechol-O-methyltransferase: optimization using Plackett-Burman and Central Composite Design." Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/1120.

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Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is an S-adenosyl-L-methionine-dependent methyltransferase enzyme that catalyzes the methylation of catechol substrates (catecholamines, catecholestrogens). Physiologically, it is responsible for the elimination of biologically active or toxic catechols, making it a protein with great clinical relevance as therapeutic target in serious disorders, like schizophrenia and Parkinson´s disease. To fulfill pharmaceuticals requirements, new strategies of optimization and large-scale production of COMT enzyme are crucial. Statistical optimization approach

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9

Stitzinger, Johannes. "Der Einfluss genetischer Variationen im COMT Gen auf kognitive Phänotypen." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-59417.

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Laatikainen, Linda Maria. "The role of catechol-O-methyltransferase (COMT) in hippocampal function." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:d0c9e1fa-a052-4af7-aaff-00548365e024.

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Catechol-O-methyltransferase (COMT) metabolises catechol-containing compounds, including dopamine. The aim of this thesis was to investigate whether COMT is involved in hippocampal function. This thesis also explored the role of functional polymorphisms within the COMT gene in the pathogenesis of schizophrenia and schizophrenia-related phenotypes. First, as part of a study investigating the role of COMT in schizophrenia, human hippocampal COMT mRNA levels were shown to be neither altered in schizophrenia or bipolar disease, nor affected by COMT genotype. Hence, functional COMT polymorphisms do

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Sutela, S. (Suvi). "Genetically modified silver birch and hybrid aspen:target and non-target effects of introduced traits." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526206844.

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Abstract The efforts to improve forest trees could be accelerated by means of genetic engineering. Thus, the performance and effects of genetically modified (GM) trees have been investigated in numerous studies, which have generally concluded that GM trees have similar effects on environment and/or other organisms as do conventionally bred trees. In the present study, GM silver birch (Betula pendula Roth) and hybrid aspen (Populus tremula L. × tremuloides Michx.) lines were utilized to study the influence of transgenes to the transcription of related endogenous genes and to the production of s

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12

CRUZ, F. T. "Caracterização Bioquímica e Estrutural da Proteína Catecol O-metiltransferase (COMT) Como Potencial Alvo para Drogas Contra Paracoccidioidomicose." Universidade Federal do Espírito Santo, 2018. http://repositorio.ufes.br/handle/10/7868.

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Made available in DSpace on 2018-08-01T22:57:54Z (GMT). No. of bitstreams: 1 tese_10914_036 - Dissertação Final - Fabiano Torres Cruz.pdf: 3514218 bytes, checksum: 20031e96ad682d105ebeadd206639253 (MD5) Previous issue date: 2018-03-28<br>A paracoccidioidomicose (PCM), micose sistêmica causada por fungos do gênero Paracoccidioides, é endêmica na América Latina, sendo o Brasil o país mais afetado. Atualmente, o tratamento com os antifúngicos tradicionais é usualmente longo, de alto custo, restrito a poucas classes de fármacos e com casos de resistência já relatados. A proteína catecol O-metilt

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Meloto, Carolina Beraldo 1983. "Caracterização de uma nova isoforma da enzima COMT associada à DTM." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290517.

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Orientador: Célia Marisa Rizzatti Barbosa<br>Tese (Doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-21T22:52:21Z (GMT). No. of bitstreams: 1 Meloto_CarolinaBeraldo_D.pdf: 1035478 bytes, checksum: c619d52bbc7d2858940483c9c5fc660e (MD5) Previous issue date: 2013<br>Resumo: Catecolamina-O-metiltransferase (COMT) é uma enzima com amplas funções biológicas, inclusive a modulação da dor, exercidas através da metabolização de substratos como a dopamina, adrenalina, e noradrenalina. Já é sabido que a atividade da COMT é gen

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14

Acosta, Conchucos Oscar. "Polimorfismo en el gen de la catecol o-metil transferasa (comt) y su asociacion con la esquizofrenia en una muestra peruana." Master's thesis, Universidad Nacional Mayor de San Marcos, 2015. https://hdl.handle.net/20.500.12672/4470.

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La Esquizofrenia es una enfermedad mental crónica y compleja que afecta al 1% de la población. El gen que codifica a la enzima catecol o-metil transferasa (COMT) es candidato de riesgo porque participa en el catabolismo de la dopamina. El polimorfismo funcional Val/Met (rs4680) en el gen COMT genera actividad enzimática diferencial, es variable en las poblaciones y ha sido asociado a la esquizofrenia. En el Perú, no existen estudios de asociación genética y es necesario implementarlas para la prevención, diagnóstico, pronóstico y farmacogenética de la enfermedad. El objetivo fue establecer la

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15

Herndon, Joseph Menzel. "Methylenedioxymethamphetamine-Induced Neurotoxicity: The Role of Hepatic Enzymes Cytochrome P450 2D6 and Catechol-O-Methyltransferase and Contribution of Microglia." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/306920.

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3,4-(±)-Methylenedioxymethamphetamine (MDMA, ecstasy) is a widely abused amphetamine derivative. The metabolism of MDMA is thought to be a necessary component of MDMA-induced neurotoxicity, as direct administration of MDMA into the central nervous system of rats failed to reproduce the hallmark serotonin deficits seen following systemic administration of MDMA. Mechanistic questions remain regarding how MDMA elicits this neurotoxicity. Work of this thesis was undertaken to examine how MDMA-induced neurotoxicity is affected by the activity of two polymorphic enzymes involved in the metabolism

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Santos, Raquel Alves dos. "Polimorfismos nos Genes CYP17, CYP1B1, CYP1A1 e COMT e as Lesões Genômicas Espontâneas em Pacientes com Câncer de Mama." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-11072008-143956/.

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O Câncer de Mama (CM) é o segundo tipo mais freqüente de câncer no mundo e a doença maligna mais comum entre as mulheres. Apesar do câncer ser considerado uma típica doença do envelhecimento, o CM apresenta algumas características distintas no que diz respeito às taxas de incidência. Os fatores de risco para o CM incluem idade da menarca precoce e menopausa tardia, terapias hormonais, exposição aos poluentes ambientais, tabagismo e etilismo, no entanto, a exposição prolongada aos estrógenos representa o fator de risco mais importante. A biossíntese e a metabolização dos estrógenos requerem um

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17

Leite, Daniela Batista [UNIFESP]. "Análise de polimorfismos nos genes CYP1A1, CYP17, COMT, GSTM1, receptor de estrogênios e progesterona em mulheres com carcinoma de ovário." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/8921.

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Made available in DSpace on 2015-07-22T20:49:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-05-27. Added 1 bitstream(s) on 2015-08-11T03:26:02Z : No. of bitstreams: 1 Publico-12476a.pdf: 514198 bytes, checksum: 306e8e833c955689b74e651234403df7 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:02Z : No. of bitstreams: 2 Publico-12476a.pdf: 514198 bytes, checksum: 306e8e833c955689b74e651234403df7 (MD5) Publico-12476b.pdf: 919832 bytes, checksum: 5b5b71d4ae84bf97e482da7ae01a38c5 (MD5). Added 1 bitstream(s) on 2015-08-11T03:26:02Z : No. of bitstreams: 3 Publico-12476a.pdf: 514198 b

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Duarte, Dante Galileu Guedes. "Estresse precoce e comportamento suicida em pacientes bipolares: estudo de associação com polimorfismos dos genes da COMT e do BDNF." Universidade Federal de Minas Gerais, 2013. http://hdl.handle.net/1843/BUOS-9AXFQE.

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The Bipolar Disorder (BD) is a psychiatric disorder associated with high rates of suicide attempts. Early life stress (ELS) one of several factors that contribute to the appearance of Suicidal Behavior and negatively influences the course of BD. There are many articles that confirm this association. We selected 47 patients with BD I, attending the Affective Disorders Clinic of the Residence of Psychiatry, Federal University of Minas Gerais (UFMG). In addition, 48 randomly selected controls by sex, age and education. Were fulfilled Hamilton depression scales, the Young Mania Scale, and a struct

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Melton, Amanda M. A. "Influence of COMT gene variant on working memory in survivors of childhood brain tumors /." Full text available from ProQuest UM Digital Dissertations, 2009. http://0-proquest.umi.com.umiss.lib.olemiss.edu/pqdweb?index=0&did=1913291401&SrchMode=1&sid=1&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1278096109&clientId=22256.

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Ott, Cordula. "Assoziation des Single Nucleotid Polymorphismus V108/158M im COMT-Gen mit Suizidalität und Persönlichkeit." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-79505.

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Stumpenhorst, Katharina. "Separate and interactive effects of catechol-o-methyltransferase and tetrahydrocannabinol on frontostriatal dopamine function." Thesis, University of Oxford, 2017. http://ora.ox.ac.uk/objects/uuid:e8eb9eba-0e32-4b30-8349-c2678207f547.

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The frontostriatal dopamine system modulates brain function and is affected by both genetic and environmental factors. Dysfunction of this system is associated with many pathological states, including schizophrenia. The enzyme catechol-O- methyltransferase (COMT) metabolises dopamine and its gene contains a polymorphism (Val<sup>158</sup>Met) that affects enzyme activity. Delta-9- tetrahydrocannabinol (THC), the main psychoactive component of cannabis, has been suggested to interact with this polymorphism to increase the risk for psychosis and cognitive impairments. Dopaminergic mechanisms are

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Jacobs, Sarah. "Development of a COMT PCR multiplex to investigate resilience, anxiety and childhood trauma in a South African population." University of the Western Cape, 2020. http://hdl.handle.net/11394/7923.

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>Magister Scientiae - MSc<br>Anxiety, resilience and childhood trauma can be categorized as functional behavioural categories, with a wealth of research behind each. The research approach adopted for each, in most cases, is either from a genetic or neuropsychological standpoint, with few studies combining both to better understand all three functional behavioural categories as a multidimensional construct A number of candidate genes have been identified as markers for anxiety, resilience and childhood trauma, of which Catechol-methyl-transferase (COMT) and several respective single nucleotide

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Lerner, Christian Daniel. "Strukturbasiertes Design, Synthese und in vitro Bewertung von Bisubstrat-Inhibitoren der Catechol-O-Methyltransferase (COMT) /." [S.l.] : [s.n.], 2003. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=15033.

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Korn, Clio. "Contributions of COMT and DAT to regulation of phasic dopamine release and reward-guided behaviour." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:8772a01d-665d-454e-9e3c-bf734331a1c2.

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Fine temporal regulation of dopamine transmission is critical to its effects on behaviour. Dopamine can be cleared from the synapse either by recycling via the dopamine transporter (DAT) or by enzymatic degradation involving catechol-O-methyltransferase (COMT). DAT recycling predominates in striatum and contributes to dopaminergic regulation of reward-guided behaviour, while COMT degradation predominates in cortex and modulates executive functions. However, human functional imaging studies demonstrate interactive effects of DAT and COMT genotype, suggesting that the traditional division betwee

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Oliveira, Angélica Salatino de. "O polimorfismo Val158Met do gene COMT e TDAH : um estudo de suscetibilidade genética e farcogenética." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/139173.

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O transtorno de déficit de atenção e hiperatividade (TDAH) é uma doença psiquiátrica de etiologia complexa, muito comum em crianças e adolescentes. Caracteriza-se pelos sintomas de desatenção, hiperatividade e impulsividade, além de uma alta taxa de comorbidade com transtornos disruptivos do comportamento. Em relação a sua neurobiologia, uma hipótese atualmente aceita é de que crianças com TDAH apresentam um déficit funcional significativo do córtex pré-frontal, com um aparente desequilíbrio de catecolaminas. A enzima Catecol-O-metiltransferase (COMT) atua na degradação de catecolaminas na fen

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Masjost, Birgit. "Structure-based design, synthesis, and in vitro evaluation of bisubstrate inhibitors for catechol o-methyltransferase (COMT) /." [S.l.] : [s.n.], 2000. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13719.

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Choudhry, Zia Ulhaq. "Catechol-O-Methyltransferase (COMT) Val 108158 Met polymorphism and ADHD : pharmaco-behavioural genetic and neurocognitive study." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112389.

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The catechol-O-methyltransferase (COMT) gene is the predominant means of dopamine deactivation within the prefrontal cortex (PFC), a brain locus implicated in Attention deficit/hyperactivity disorder (ADHD). Dopamine dysregulation is a significant contributor to the pathophysiology of ADHD and Methylphenidate (MPH), an effective treatment for ADHD, and acts at least in part, through modulation of dopamine levels in the PFC. Thus, we tested the hypothesis that the Catechol-O-Methyltransferase (COMT) Val108/158 Met polymorphism modulates behavioral dimensions relevant for ADHD and/or response of

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García, García Manuel Antonio. "The role of COMT, DAT and DRD2 polymorphisms on brain mechanisms of involuntary attention and cognitive control." Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/2722.

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Our genetic background plays a role in the way we face environmental changes and adapt our behavior adequately to the requirements of everyday life. The present research focuses on the role of three genes related to dopamine (DA) transmission on relevant cognitive processes, such as shifting attention when required by the environmental demands or processing of unexpected but potentially relevant events. Prefrontal cortex (PFC) and striatum dopamine activity seem to play different roles in attentional processing and interact to regulate stability and flexible update of context information. Ther

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Wendler, Franziska Verfasser], and Stefan [Akademischer Betreuer] [Pollmann. "Genetic influences on long-term memory control : COMT and retrieval-induced forgetting / Franziska Wendler. Betreuer: Stefan Pollmann." Magdeburg : Universitätsbibliothek, 2014. http://d-nb.info/1054638551/34.

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Capitão, Luísa Maria Sousa Ribeiro. "Estudo dos polimorfismos CYP1B1 VAL432 LEU, MTHFR Ala225VAL e COMT VAL158 Met como factores de risco de cancro da mama em mulheres da Beira Interior." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2007. http://hdl.handle.net/10216/22131.

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Capitão, Luísa Maria Sousa Ribeiro. "Estudo dos polimorfismos CYP1B1 VAL432 LEU, MTHFR Ala225VAL e COMT VAL158 Met como factores de risco de cancro da mama em mulheres da Beira Interior." Dissertação, Faculdade de Medicina da Universidade do Porto, 2007. http://hdl.handle.net/10216/22131.

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Cuyàs, Navarro Elisabet. "Pharmacogenetic mechanisms (COMT and hSERT) modulating deleterious effects of MDMA and cannabis on cognitive performance in drug users." Doctoral thesis, Universitat Autònoma de Barcelona, 2011. http://hdl.handle.net/10803/48529.

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La neurotransmissió dopaminèrgica i serotonèrgica al còrtex preforntal i a les regions del sistema límbic són un dels principals substrats cerebrals de les funcions executives (implicades en l’organització i el control) i la regulació emocinal. Tant la MDMA com el cannabis alteren la funcionalitat d’aquests sistemes de neurotransmissió. Certs polimorfismes funcionals de la catecol-Ometiltransferasa (COMT) i del transportador de serotonina (hSERT) s’han associat a diferències individuals en el funcionament cognitiu. La interacció entre ambdós gens juntament amb factors ambientals poden e

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Lewandowski, Kathryn Eve. "The role of COMT in schizophrenic-like cognitive impairment and social functioning in children with 22q11 deletion syndrome." Greensboro, N.C. : University of North Carolina at Greensboro, 2007. http://libres.uncg.edu/edocs/etd/1480Lewandowski/umi-uncg-1480.pdf.

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Thesis (Ph. D.)--University of North Carolina at Greensboro, 2007.<br>Title from PDF t.p. (viewed Feb. 29, 2008). Directed by Thomas R. Kwapil; submitted to the Dept. of Psychology. Includes bibliographical references (p. 79-111).

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Herrmann, Lennard Manes Richard [Verfasser], Siegfried Martin [Gutachter] Muhlack, and Ludgera Martina [Gutachter] Ossege-Pohle. "COMT-Inhibitoren in der Parkinson-Therapie / Lennard Manes Richard Herrmann. Gutachter: Siegfried Martin Muhlack ; Ludgera Martina Ossege-Pohle." Bochum : Ruhr-Universität Bochum, 2016. http://d-nb.info/1102524948/34.

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Schuh, Artur Francisco Schumacher. "Farmacogenética da levodopa na doença de Parkinson : estudo de polimorfismos nos genes da COMT, MAO-B e DAT." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/39639.

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A doença de Parkinson é a segunda enfermidade neurodegenerativa mais frequente e acomete entre 1 a 2% das pessoas acima de 65 anos. Com a expectativa de envelhecimento da população, espera-se um aumento proporcional da prevalência desta doença, o que justifica uma preocupação crescente com o manejo dessa condição. A levodopa é fundamental para o manejo farmacológico desses pacientes, uma vez que é possível um controle quase ótimo dos sintomas, pelo menos nos primeiros anos de tratamento. Entretanto, em cinco anos, cerca de metade dos pacientes apresentarão complicações pelo uso crônico desta m

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Alazizi, Adnan. "Molecular Cloning, Expression, purification and Characterization of the Zebrafish Catechol-O-methyltransferases." University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1303391786.

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Giannunzio, Valeria. "Different Types of Decision Making Impairments in Anorexia Nervosa." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3424927.

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Research on neurocognitive aspects in Anorexia Nervosa (AN) has outlined a cognitive profile characterized by deficiency in the ability to set-shifting (cognitive flexibility) and weak central coherence. A smaller agreement emerges in relation to the compromission of decisional profiles frequently observed in patients with AN since both the complexity of the pathology and the executive function itself make it unclear the nature of these alterations and its relationships with specific or independent clinical and enviornmental variables. The aim of this study was: to investigate different types

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Nüsser, Corinna. "Neuronale Korrelate von Delay Discounting." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-23427.

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Delay Discounting im Sinne eines Abwertens zukünftiger Belohnungen ist ein weit verbreitetes Phänomen. Es zeigt sich z. B. in persönlichen Angelegenheiten, wie der Entscheidung für den kurzfristigen Genuss von Süßigkeiten und gegen die langfristigen, durchaus größeren Vorteile einer schlanken Figur. Auch internationale wirtschaftliche und politische Diskussionen zum Klimaschutz oder der Finanzkrise werden von der Präferenz für sofortige, kleinere Belohnungen über verzögerte, größere Belohnungen getrieben. In der Psychologie wird Delay Discounting als Maß für Impulsivität bzw. Selbstkontrolle m

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Fasolo, Juliana Maria de Mello Andrade. "Aplicação de CLAE-DAD-EM e CG-EM na caracterização de Blechnum sp. e abordagens in vitro e in silico para a avaliar o perfil multifuncional do ácido rosmarínico em alvos relacionados à neurodegeneração e toxicidade em células-tronco." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/149457.

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As plantas medicinais são consideradas importantes fontes de compostos biologicamente ativos. Para muitas doenças crônicas, como as neurodegenerações, substâncias que apresentam atividades simultâneas em mais de um alvo relacionado à etiopatologia dessas desordens, constituem potenciais agentes terapêuticos. Nesse contexto, os objetivos deste trabalho foram a avaliação química e biológica de três espécies de samambaias de ocorrência no sul do Brasil: Blechnum binervatum, B. brasiliense e B. occidentale. O isolamento bioguiado foi utilizado para a identificação da(s) substância(s) com potencial

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Miguita, Karen. "Estudo de associação de genes candidatos no transtorno obsessivo-compulsivo: investigação dos loci SLC6A4, HTR1B, HTR2A, SLC6A3, COMT e SLC6A2." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-23102007-110042/.

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O Transtorno obsessivo-compulsivo (TOC) é um transtorno psiquiátrico comum e heterogêneo caracterizado por obsessões (pensamentos, imagens ou impulsos intrusivos e recorrentes) e compulsões (comportamentos ou atos mentais repetitivos realizados para aliviar as obsessões). O TOC tem uma prevalência de 2 a 3% na população geral e apresenta distribuição aproximadamente igual entre os sexos, porém os homens tendem a apresentar os sintomas obsessivo-compulsivos mais precocemente quando comparado com as mulheres. Os estudos de genética epidemiológica têm demonstrado que o fator genético é um importa

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Wortmann, Viola [Verfasser], and Volker [Akademischer Betreuer] Arolt. "Hippokampale Volumenveränderung und COMT-Val-108/158-Met-Polymorphismus bei Patienten mit akuter unipolarer Depression / Viola Wortmann. Betreuer: Volker Arolt." Münster : Universitäts- und Landesbibliothek der Westfälischen Wilhelms-Universität, 2011. http://d-nb.info/1027017762/34.

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Armbruster, Diana. "The impact of serotonergic and dopaminergic genetic variation on endophenotypes of emotional processing." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-63574.

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Decades of research in quantitative genetics have found substantial heritability for personality traits as well as for mental disorders which formed the basis of the ongoing molecular genetic studies that aim to identify genetic variations that actually contribute to the manifestation of complex traits. With regard to psychological traits, genetic variation impacting neurotransmitter function have been of particular interest. Additionally, the role of environmental factors including gene × environment interactions has been further investigated and the impor-tance of developmental aspects has b

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Caldú, i. Ferrús Xavier. "Influència de les variants genètiques de la COMT i el DAT en l'activació cerebral i en el processament cognitiu i emocional." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/2703.

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D'entre totes les catecolamines, la dopamina és la més important del sistema nerviós central, on regula funcions com la conducta motora, les emocions i la cognició. Donada la implicació del sistema dopaminèrgic en diverses disfuncions cerebrals, com ara l'esquizofrènia, la malaltia de Parkinson o el trastorn per dèficit d'atenció amb hiperactivitat, l'estudi d'aquest sistema ha esdevingut de gran importància. Els dos mecanismes més importants de terminació de l'activitat dopaminèrgica a nivell sinàptic són la recaptació mitjançant el transportador de la dopamina (DAT) i la degradació a través

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Chau, Cecil Ming Yeung. "Neonatal pain and COMT Val158Met genotype in relation to serotonin transporter (SLC6A4) promoter methylation in very preterm children at school age." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/55054.

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Children born very preterm are exposed to repeated neonatal procedures that induce pain and stress during hospitalization in the neonatal intensive care unit (NICU). The COMT Val158Met genotype is involved with pain sensitivity, and early life stress is implicated in altered expression of methylation of the serotonin transporter. We examined: (1) whether methylation of the serotonin transporter gene (SLC6A4) promoter differs between very preterm children and full-term controls at school age, (2) relationships with child behavior problems, and (3) whether the extent of neonatal pain exposure in

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Godinez, Detre. "The Wisconsin Card Sorting Task: An analysis of the construct validity, heritability, and association with the COMT Val(158)Met polymorphism." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3273679.

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Kube, Johanna [Verfasser]. "Varianten im COMT-Gen und neue Urinmarker zur Risikoabschätzung der Entwicklung einer akuten und chronischen Nierenschädigung nach kardiochirurgischen Eingriffen / Johanna Kube." Magdeburg : Universitätsbibliothek, 2018. http://d-nb.info/1174626607/34.

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Wright, Galen Egan Buckley. "Molecular genetic analysis of two genes, CYP2D6 and COMT, in the schizophrenia-susceptibility locus on chromosome 22q in the Xhosa population." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20366.

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Büttner, Claudia Sophia [Verfasser], and Caroline [Akademischer Betreuer] Jung-Sievers. "Assoziation von Polymorphismen im COMT-Gen mit der Schizophrenie und dem Arbeitsgedächtnis als Endophänotyp / Claudia Sophia Büttner. Betreuer: Caroline Jung-Sievers." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1106854578/34.

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Daubitz, Torsten [Verfasser], and Andreas J. [Gutachter] Fallgatter. "Einfluss des COMT-Polymorphismus auf das Sensorische Gating bei erwachsenen ADHS-Patienten und gesunden Kontrollen / Torsten Daubitz. Gutachter: Andreas J. Fallgatter." Würzburg : Universität Würzburg, 2014. http://d-nb.info/1110028075/34.

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Akdenizli, Kemal [Verfasser]. "Bedeutung genetischer Polymorphismen in BDNF, Bcl-2 sowie COMT und MAO-A für den Erfolg der Therapie mit Antidepressiva / Kemal Akdenizli." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023783568/34.

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