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Artykuły w czasopismach na temat "COMT"
&NA;. "COMT inhibitors". Inpharma Weekly &NA;, nr 1135 (maj 1998): 6. http://dx.doi.org/10.2165/00128413-199811350-00009.
Pełny tekst źródłaMeloto, Carolina B., Samantha K. Segall, Shad Smith, Marc Parisien, Svetlana A. Shabalina, Célia M. Rizzatti-Barbosa, Josée Gauthier i in. "COMT gene locus". PAIN 156, nr 10 (październik 2015): 2072–83. http://dx.doi.org/10.1097/j.pain.0000000000000273.
Pełny tekst źródłaO’Tuathaigh, Colm. "S.12.2 - COMT". Behavioural Pharmacology 24 (październik 2013): e15. http://dx.doi.org/10.1097/01.fbp.0000434735.74603.db.
Pełny tekst źródłaPapaleo, F., M. C. Burdick, J. H. Callicott i D. R. Weinberger. "COMT–Dysbindin epistatic interaction". Molecular Psychiatry 19, nr 3 (21.02.2014): 273. http://dx.doi.org/10.1038/mp.2014.6.
Pełny tekst źródłaSemen, M. O., O. L. Lychkovska, I. E. Shymanska, V. D. Semen i H. V. Makukh. "High frequency of the 472AA COMT (Val158) homozygous genotype of the catechol-O-methyltransferase (COMT) gene in children with irritable bowel syndrome". Modern pediatrics. Ukraine, nr 6(126) (29.10.2022): 23–29. http://dx.doi.org/10.15574/sp.2022.126.23.
Pełny tekst źródłaAdler, Charles H. "COMT Inhibitors: Novel Treatments for Parkinson's Disease". CNS Spectrums 3, nr 2 (luty 1998): 53–56. http://dx.doi.org/10.1017/s109285290000554x.
Pełny tekst źródłaBelfer, I., i S. Segall. "COMT genetic variants and pain". Drugs of Today 47, nr 6 (2011): 457. http://dx.doi.org/10.1358/dot.2011.47.6.1611895.
Pełny tekst źródłaZammit, Stanley, Michael J. Owen, Jonathan Evans, Jon Heron i Glyn Lewis. "Cannabis, COMT and psychotic experiences". British Journal of Psychiatry 199, nr 5 (listopad 2011): 380–85. http://dx.doi.org/10.1192/bjp.bp.111.091421.
Pełny tekst źródłaMartinez-Martin, P., i C. F. O'Brien. "Extending levodopa action: COMT inhibition". Neurology 50, Issue 6, Supplement 6 (1.06.1998): S27—S32. http://dx.doi.org/10.1212/wnl.50.6_suppl_6.s27.
Pełny tekst źródłaDorflinger, E., G. Magni i F. Hoffmann. "COMT inhibition and Parkinson's disease". European Neuropsychopharmacology 8 (listopad 1998): S87—S88. http://dx.doi.org/10.1016/s0924-977x(98)80057-6.
Pełny tekst źródłaRozprawy doktorskie na temat "COMT"
Gonçalves, Ana Margarida Ribeiro. "Isoformas da enzima catecol-O-metiltransferase como alvo farmacológico na doença de Parkinson". Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1636.
Pełny tekst źródłaThis work is divided in two chapters. Chapter I covers the stage held in Community Pharmacy, on Pharmacy Ferrer - Castelo Branco. Besides describing the facilities and their spatial organization, the technical team and its functions, there is an approach to the informatics system used (Sifarma 2000), and there are also described the various activities carried out during the stage, from the ordering process, reception and storage, providing pharmaceutical care, preparation of compounded medications, dispensing prescribed and non-prescribed medications, billing, among others. Pharmaceutical legislation, involved in pharmaceutical practice is also explored in this chapter. Chapter 2 covers a bibliographic review on the isoforms of catechol-O-metiltransferase enzyme as pharmacological target in Parkinson's disease. Parkinson's disease is a neurodegenerative disease, which is involved in the loss of dopaminergic neurons of the substantia nigra (pars compacta). It affects about 1% of the population over 65 years and it is thought that genetic and environmental factors are at their origin. The catechol-O-methyltransferase (COMT) is present in both eukaryotic and prokaryotic. It is an intracellular protein, and in mammals is distributed uniformly throughout the body, presenting highest activity in the liver, kidney and gastrointestinal tract. Its main function is the metabolism of molecules with catechol structure biologically active, whether endogenous or exogenous. Presents several polymorphisms, where the polymorphism involved in the replacement of Valine by Methionine is the only one in which the function is known. Manifests as two isoforms, the soluble form (S-COMT) and the membrane form (MB-COMT), being the soluble form more prevalent in the body, except the brain. In addition to the distribution in the body, they also differ in subcellular localization, kinetic properties, substrate specificity and molecular weight. Levodopa is considered the most effective therapy in Parkinson's disease, since the 60s. It is administered with decarboxylase inhibitors of aromatic amino acid (DAAA). In patients with motor fluctuations, is co-administered with COMT inhibitors. Currently entacapone is the only available inhibitor, however, opicapone, in the third Phase of clinical trials, presents a greater inhibition, in which a single daily dose is enough, unlike entacapone.
Andersson, Anneli. "Katekol-O-Metyltransferas (COMT), tidigare övergrepp, gen-miljöinteraktion i förutsägelsen för våld". Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-42712.
Pełny tekst źródłaSeveral candidate genes have been suggested to play a role in the development of antisocial behavior in association with social and environmental factors. Therefore, the purpose of the present study was to investigate the relationship between the gene Catechol-O-Methyltransferase (COMT) and violence; and to examine whether there were interactions between earlier abuse and COMT in the association of violence. Data were drawn from a Swedish population-based study including 2,500 20-24 year olds. The present study found that depending on which variant of the gene one possess, one will be affected to different degree of adverse environmental factors in association with violence.
CASTELLANO, FILIPPO. "Funzioni Esecutive e Facial Emotion Recognition in Persone Affette da Schizofrenia: ruolo del Polimorfismo del COMT e dell'Abuso di Alcol e Sostanze". Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/94538.
Pełny tekst źródłaBACKGROUND: cognitive and genetic features are increasingly important in the study of schizophrenia. The impairment of executive function (FE) and facial emotion recognition, are central issues in schizophrenic disease. To date, however, the paradigm of the (dis) cognitive functioning in schizophrenia is based on studies that excluded subjects with schizophrenia and a history of substance abuse (SUD)(5), which is actually a phenomenon that showed a derogatory impact on cognition in the population with substance use disorder. The literature has also over the years defined polymorphisms potentially implicated in both schizophrenia and in alcohol and substance use disorders, such as the one (rs4680) related to the gene of catechol-O-methyltransferase (COMT). Given the prevalence of the phenomenon and the association between cognition, functional outcome and genetic polymorphisms, the study of these related in schizophrenic patients with substance abuse is an important issue for a more precise stratification diagnosis, prognosis and treatment. AIM: to evaluate the impact of the COMT polymorphism and alcohol and substance abuse on cognitive performance in a population of subjects with schizophrenia. MATERIALS AND METHODS: this is a observational study. We recruited 62 subjects (M = 50, F = 12) diagnosed with schizophrenia according to DSM-IV (assessed by the Structured Clinical Interview for DSM-IV, SCID I). The sample was subdivided according to the presence or not of alcohol abuse and related substances (evaluated with the Alcohol and Drug Use Scale -Aus and DUS) into two groups (SKZ+SUD and SKZ-SUD), which were then compared with regard to socio-demographic and clinical characteristics (Positive and Negative Syndrome Scale - PANSS). It was then analysed the association between the condition of abuse, COMT polymorphism and score on Intra-Extra Dimensional Shift September (IED), which evaluates the FE and on test Ekman, evaluating the FER, controlling for socio-demographic and clinical variables. RESULTS: the two groups SKZ+SUD (n= 8) and SKZ-SUD (n = 34) show a statistically significant difference by age with mean (SD) of 47.21 (9.41) in abusers and 36.04 (10.09) in non-abusers (p <0.001). Abusers tend to make fewer errors on IED (IED errors adjusted Total 47.32 (47.77) vs 70.59 (70.84); p = 0:26), fewer trials (IED trials Total Adjusted 136.61 (85.65) vs 178.35 (128.02); p = 0:24) to reach the criterion to overcome the stage and a greater number of stages completed (IED stages completed 7.79 (2.11) vs 6.85 (3.12), p = 0:35). Abusers (mean = 41.86 (7:50)) show a score statistically higher (p = 0.02) compared with non-abusers (mean = 35.29 (11.79) on Ekman test. On IED (stage completed), checking for the PANSS, the Met-Met genotype compared with Val-Val genotype was different in the group of abuse compared with the group not abusing (interaction coefficient -4.09 CI [-8.06, -0.13]; p = 0.043): Met-Met show a worse performance than in the group of Val-Val. The same type of interaction is confirmed also with regard to the Ekman , although not reaching statistical significance (interaction with coefficient -6.46 CI [-0.83, 13.76]; p = 0.081). CONCLUSIONS: subjects with schizophrenia and substance abuse seems to be less compromised from a neuropsychological point of view than those without abuse. Furthermore it is shown an interaction between the polymorphism for COMT gene and the condition of alcohol and substance abuse with regard to the FE and FER performance.
da, Silva Costa Isis. "Variations in EEG and motor functions related to COMT gene in patients with fibromyalgia". Doctoral thesis, Universitat de les Illes Balears, 2017. http://hdl.handle.net/10803/399443.
Pełny tekst źródłaLa fibromialgia (FM) és una síndrome crònica caracteritzada per dolor generalitzat, fatiga, son no reparador, queixes somàtiques i alteracions afectives i cognitives. Encara que existeixen evidències indicant que emocions negatives poden tenir un paper modulador rellevant en el manteniment dels símptomes de la FM, poc es coneix de la influència dels polimorfismes genètics sobre la funció motora, el son i el processament afectiu en la fibromiàlgia. L’objectiu principal d’aquesta tesi doctoral va ser analitzar la influència del polimorfisme val158met del gen de la COMT, que es troba associat a l’activitat enzimàtica de la degradació de les catecolamines, sobre la marxa i l’equilibri, el son i la regulació emocional. Per això, s’ha adoptat un enfocament multidisciplinari en el qual s’han tingut en conte paràmetres biomecànics de la funció motora, l’activitat cerebral durant el son i durant la modulació afectiva del reflex de sobresalt per comparar subjectes que mostren una baixa o alta activitat de COMT (homozigots met i portadors d’al·lel val, respectivament). La funció motora fou avaluada mitjançant l’anàlisi de la marxa i l’equilibri amb gravacions de video en persones sanes i en pacients amb FM (estudi 1). A més, dos grups de pacients amb FM basats en el polimorfisme de la COMT participaren en un registre polisomnogràfic nocturn (estudi 2), i en una tasca experimental ambla presència d’estímuls acústics de sobresalt durant la visualització d’imatges afectives (estudi 3). L’estudi 1 mostrà que les pacients amb FM presenten una disminució significativa en paràmetres de la marxa com són la velocitat, la longitud de cada pas i del pas complet o cadència, així com dèficits en el control postural i de l’equilibri. L’estudi 2 desvetllà que les pacients amb FM amb baixa activitat de l’enzim COMT pareixen estar més impactades físicament, més deprimides i amb pitjor qualitat de son (major nombre de despertars durant la nit, major quantitat de temps en el llit i un son més fragmentat durant la fase REM), que les pacients amb FM amb alta activitat de l’enzim COMT. Per últim, l’estudi 3 mostrà que les pacients con FM amb baixa activitat de l’enzim COMT presenten alteracions significatives en els components primerencs de l’activitat cerebral desencadenada per estímuls agradables o desagradables, comparades amb les pacients con FM amb alta activitat del COMT. Aquests estudis suggereixen: 1) la marxa i l’equilibri es troben alterats en les pacients amb FM comparades amb les persones sense dolor, i 2) que el son i el processament afectiu de les pacients amb FM port estar modulat pel polimorfisme val158met del gen del COMT que regula l’activitat enzimàtica de les catecolamines. En resum, aquests resultats remarquen encara més la idea de que els símptomes de la fibromiàlgia precisen d’una avaluació i d’una intervenció terapèutica de caràcter multidimensional amb l’objectiu de proporcionar les òptimes condicions per la millora de la qualitat de vida d’aquetes pacients. Així mateix, aquestes troballes subratllen la rellevància de considerar els marcadors genètics i neurofuncionales per a una compressió més completa de la síndrome de fibromiàlgia.
Fibromyalgia (FM) is a chronic syndrome characterized by widespread pain, fatigue, unrefreshing sleep, somatic complaints, and affective and cognitive alterations. Although there is recent evidence indicating that negative affect may play a relevant modulatory role for the maintenance of fibromyalgia symptoms, little is known about how genetic polymorphisms may influence motor function, sleep and affective processing in fibromyalgia. The major goal of the present thesis was to analyze the influence of the val158met polymorphism of the COMT gene which is associated with the enzymatic activity level of cathecolamine degradation on gait and balance, sleep and emotional regulation. For this purpose, a multidisciplinary approach taking into account biomechanical parameters of motor function and parameters of the brain activity during sleep and during affective processing was used to compare individuals displaying either low (met homozygotes) or high COMT activity (val carriers). Motor function was assessed by analyzing gait and balance through video recordings in healthy controls and FM patients (study 1). In addition, two subsamples of FM patients based on the val158met polymorphism participated in a night polysomnography recording (study 2) and an experimental task with presentation of startle noise stimuli when viewing affective pictures (study 3). Study 1 showed that FM patients display a significant reduction in gait parameters such as speed, step length and full step, cadence and etc., as well as deficits in postural control and balance. Study 2 revealed that FM patients with low-activity of the COMT enzyme appear to be more physically impacted and depressed, and to have poorer quality of sleep (greater number of awakenings during the night, longer in bed and more fragmented sleep during REM) than FM patients with high-activity of the COMT enzyme. Finally, Study 3 showed that patients with low-activity of the COMT enzyme display significant alterations of the early components of the event-related brain potentials elicited by pleasant and unpleasant stimuli as compared with FM patients displaying high COMT activity. These studies suggest: 1) that gait and balance are altered in patients with FM compared to pain-free controls, and 2) that sleep and affective processing in FM patients may be modulated by the val158met polymorphism of the COMT gene that regulates the enzyme activity of catecholamines. In summary, these findings provide further support for the notion that FM symptoms would require multidimensional assessment and intervention to provide optimal conditions for improving quality of life in these patients. Moreover, our findings underline the relevance of considering genetic and neurofunctional markers for a complete understanding of fibromyalgia.
Barbosa, Marta Cristina Fornelos. "Sistema Nervoso Central: planeamento químico-farmacológico para obtenção de um novo alvo terapêutico para a doença de Parkinson". Master's thesis, [s.n.], 2012. http://hdl.handle.net/10284/3205.
Pełny tekst źródłaO presente trabalho pretende seguir uma linha de investigação pré-laboral, mas de enorme potencial devido à possibilidade de apresentar uma significativa redução nos custos aquando do lançamento de uma nova solução terapêutica. O trabalho será desenvolvido na área do sistema nervoso central (SNC) e a doença abordada será a doença de Parkinson. No decorrer deste trabalho irá ser feito uma abordagem ao tratamento farmacológico da DP, e realizado um estudo químico-farmacológico de potenciais novos inibidores da COMT. A Doença de Parkinson (DP) é uma patologia cerebral em que ocorre morte dos neurónios numa zona do cérebro designada de substância negra. É a segunda doença neurodegenerativa mais frequente depois da doença de Alzheimer. This work intends to pursue a line of pre-employment investigation, but with great potential due to the possibility of presenting a significant cost reduction at the launch of a new therapeutic solution. The work will be developed in the area of the central nervous system (CNS) and the disease discussed will be Parkinson's disease. We will make an approach to the pharmacological treatment of PD, and we will conduct a chemical and pharmacological study of potential new COMT inhibitors. Parkinson's disease (PD) is a brain pathology in which occurs neuronal death in an area of the brain called substantia nigra. It is the second most common neurodegenerative disorder after Alzheimer's disease.
Ho-Yue-Kuang, Séverine. "Exploration des voies de biosynthèse de l’acide férulique dans les grains et tiges de Brachypodium distachyon". Nantes, 2015. https://archive.bu.univ-nantes.fr/pollux/show/show?id=ed667b2c-bd04-465a-bea7-b1ae49162a58.
Pełny tekst źródłaFerulic acid plays a key role in grass cell walls, allowing the reticulation between chains of polysaccharides and with lignins. The understanding of its biosynthesis could improve cereals end-uses in allowing the modulation of the cell wall mechanical properties and enzymatical digestibility. The model plant of Poaceae, Brachypodium distachyon, was used to explore the ferulic acid biosynthesis pathways. A reverse genetic strategy has been established to study two candidate enzymes, the COMT and the CCoAOMT selected for their capacity to produce in vitro ferulic acid and feruloylCoA respectively. Since these OMTs are encoded by multigenic families, a selection of candidate genes has been performed based on phylogenetic and transcriptomic analyses. Mutant lines have been obtained through chemical mutagenesis and identified by TILLING for the BdCOMT6 gene. The analysis of these lines showed that BdCOMT6 is a COMT involved in lignin biosynthesis in B. Distachyon stems and grains. However it would not produce the ferulic acid linked to cell walls. RNA interference lines targeting five CCoAOMT genes belonging to a Poaceae specific clade have been generated. Ferulic acid linked to stem cell walls was detected by preliminary analyses of the regenerated plants. Complementary analyses of the next generations are in progress, they will allow to determine if these CCoAOMT genes have a role in the biosynthesis of ferulic acid linked to cell wall. Lignins have been studied in details over the last few years, only stem lignins were characterized in B. Distachyon, this doctoral work allowed to precisely characterize, and for the first time, the structure of the grain lignins
Kawa, Kevin Hideyuki, i Kevin Hideyuki Kawa. "Genetic and Neuroanatomic Factors that Influence Executive Functions in Aging". Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/622974.
Pełny tekst źródłaStitzinger, Johannes. "Der Einfluss genetischer Variationen im COMT Gen auf kognitive Phänotypen". Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-59417.
Pełny tekst źródłaLaatikainen, Linda Maria. "The role of catechol-O-methyltransferase (COMT) in hippocampal function". Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:d0c9e1fa-a052-4af7-aaff-00548365e024.
Pełny tekst źródłaSoares, Rui Filipe Lopes. "Biosynthesis of human membrane-bound Catechol-O-methyltransferase: optimization using Plackett-Burman and Central Composite Design". Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/1120.
Pełny tekst źródłaCatecol-O-metiltransferase (COMT, CE 2.1.1.6) é uma enzima metiltransferase dependente de S-adenosil-L-metionina (SAM) que catalisa a metilação de substratos catecóis (catecolaminas, catecolestrogénios). Fisiologicamente, é responsável pela eliminação de catecóis biologicamente activos ou tóxicos, tornando-a uma proteína de elevado interesse clínico e utilizada como alvo terapêutico em doenças graves, como a esquizofrenia e a doença de Parkinson. Para suprir as necessidades farmacêuticas, novas estratégias de otimização e produção em larga escala desta enzima são fundamentais. Abordagens de otimização estatística têm demonstrado o seu enorme valor à escala laboratorial e industrial, nomeadamente nos processos de produção biotecnológicos, em que um pequeno detalhe melhorado pode significar um grande passo para o sucesso. Neste trabalho, objetivou-se a otimização do nível de atividade enzimática da proteína recombinante COMT, na sua forma membranar, através do recurso a modelos de otimização estatística como uma abordagem resolutiva. Numa primeira fase de otimização e de seleção dos fatores mais significativos para a atividade enzimática da proteína em estudo foi utilizada a técnica de desenho experimental Plackett-Burman. Após esta seleção foi aplicada a Metodologia de Superfície de Resposta (RSM), através de desenho composto central (DCC), para otimização da concentração dos fatores que revelaram ser mais significativos e, consequentemente, do processo. Foi utilizado o sistema de expressão Brevibacillus choshinensis para a biossíntese da proteína membranar COMT e um meio semi-definido para o seu crescimento. Este meio foi submetido a uma primeira triagem através do desenho experimental Plackett-Burman, avaliando-se desta forma a influência dos parâmetros de cultura (produtos químicos e físicos) nos níveis de actividade enzimática da COMT membranar. Os níveis de actividade enzimática foram medidos num sistema de cromatografia líquida de alta eficiência acoplado a um detector amperométrico. Entre as onze variáveis testadas, a polipeptona, sulfato de amónio, glucose e temperatura foram as variáveis selecionadas dado o seu significativo efeito na actividade enzimática da COMT membranar. Os níveis de atividade enzimática obtidos nesta primeira triagem revelaram-se bastante promissores, sendo mais elevados do que os obtidos com o meio 2SYNm, meio de crescimento mais comum para as células usadas neste trabalho. Foram obtidos valores de 93nmol/h para a actividade enzimática total e cerca 30 nmol/h/mg de actividade enzimática específica com a proteína na sua forma nativa, sem o uso de qualquer tipo de detergentes no processo de solubilização. Com base nos resultados do desenho Plackett Burman foi aplicado o desenho Composto Central para a otimização dos quatro fatores em causa a fim de maximizar a nossa resposta. Este apresentou um valor do coeficiente de correlação múltipla de 0,635 e uma falta de ajuste significativa, demonstrando a falta de adequação do modelo para a otimização do processo.
Książki na temat "COMT"
Royal Society of Medicine (Great Britain), red. Parkinson's disease: Extending the effectiveness of levodopa through COMT and MAO-B inhibition. London: Royal Society of Medicine Press, 2006.
Znajdź pełny tekst źródłaOliver, Cookie Dawkins. Come Comet, come Cupid. Nashville, TN: Winston-Derek Publishers, 1992.
Znajdź pełny tekst źródłaWinn, Steven. Come Back, Como. New York: HarperCollins, 2009.
Znajdź pełny tekst źródłaProença, Ruy. Como um dia come o outro. São Paulo, SP, Brasil: Nankin Editorial, 1999.
Znajdź pełny tekst źródłaJ, Brinker Barry, red. Guide to cost management. New York: Wiley, 2000.
Znajdź pełny tekst źródłaYi, Li Yuyao, red. Hui lai ba, Ke mo: Come back, Como. Nanjing: Yi lin chu ban she, 2011.
Znajdź pełny tekst źródłaShaffer, Marvin. Multiple account benefit-cost analysis: A practical guide for the systematic evaluation of project and policy alternatives. Toronto: University of Toronto Press, 2010.
Znajdź pełny tekst źródłaCutting costs effectively in recession & recovery. [United States?]: RecessionStormingMedia, 2009.
Znajdź pełny tekst źródłaShaffer, Marvin. Multiple account benefit-cost analysis: A practical guide for the systematic evaluation of project and policy alternatives. Toronto: University of Toronto Press, 2010.
Znajdź pełny tekst źródłaAnderson, Lee G. Analyse coûts-avantages: Un guide pratique. Sillery, Qué: Presses de l'Université du Québec, 1990.
Znajdź pełny tekst źródłaCzęści książek na temat "COMT"
Hoyer, Daniel, Eric P. Zorrilla, Pietro Cottone, Sarah Parylak, Micaela Morelli, Nicola Simola, Nicola Simola i in. "COMT Inhibitor". W Encyclopedia of Psychopharmacology, 324. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_948.
Pełny tekst źródłaPeter, Helga, i Thomas Penzel. "COMT-Hemmer". W Springer Reference Medizin, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-54672-3_407-1.
Pełny tekst źródłaMännistö, P. T., I. Ulmanen, K. Lundström, J. Taskinen, J. Tenhunen, C. Tilgmann i S. Kaakkola. "Characteristics of catechol O-methyltransferase (COMT) and properties of selective COMT inhibitors". W Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques, 291–350. Basel: Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-7144-0_9.
Pełny tekst źródłaO’Tuathaigh, Colm M. P., Lieve Desbonnet i John L. Waddington. "Cannabinoids, Monoamines, COMT and Schizophrenia: Pathobiological Mechanisms in Psychosis". W Endocannabinoid Regulation of Monoamines in Psychiatric and Neurological Disorders, 297–323. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-7940-6_14.
Pełny tekst źródłaHe, Zhaohui, Xiaochuan Sun, Zongduo Guo i John H. Zhang. "Expression and Role of COMT in a Rat Subarachnoid Hemorrhage Model". W Early Brain Injury or Cerebral Vasospasm, 181–87. Vienna: Springer Vienna, 2011. http://dx.doi.org/10.1007/978-3-7091-0353-1_32.
Pełny tekst źródłaValente, Nina Leão Marques, Jose Paulo Fiks i Marcelo Feijó de Mello. "Catechol-O-Methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD". W Comprehensive Guide to Post-Traumatic Stress Disorders, 1019–31. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-08359-9_27.
Pełny tekst źródłaValente, Nina Leão Marques, Jose Paulo Fiks i Marcelo Feijó de Mello. "Catechol-O-Methyltransferase (COMT) val158met Polymorphism as a Risk Factor for PTSD". W Comprehensive Guide to Post-Traumatic Stress Disorder, 1–11. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-08613-2_27-1.
Pełny tekst źródłaZürcher, G., A. Colzi i M. Prada. "Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues". W Amine Oxidases and Their Impact on Neurobiology, 375–80. Vienna: Springer Vienna, 1990. http://dx.doi.org/10.1007/978-3-7091-9113-2_51.
Pełny tekst źródłaKostić, Vladimir S. "COMT Inhibition in the Treatment of Parkinson’S Disease: Neuroprotection and Future Perspectives". W Advances in Experimental Medicine and Biology, 75–90. Boston, MA: Springer US, 2004. http://dx.doi.org/10.1007/978-1-4419-8969-7_5.
Pełny tekst źródłaRuß, H. M., W. Kuhn i H. Przuntek. "Der Einfluß von R-(-)-Deprenyl auf die COMT-Aktivität beim Morbus Parkinson". W Verhandlungen der Deutschen Gesellschaft für Neurologie, 209–11. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83771-5_41.
Pełny tekst źródłaStreszczenia konferencji na temat "COMT"
Lu, Liping, i Jiannong shi. "Association between Creativity and COMT Genotype". W 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5515671.
Pełny tekst źródłaLu, Liping, i Jiannong Shi. "Association between Intelligence and COMT Genotypes in Chinese Healthy Children". W 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5515844.
Pełny tekst źródłaIvanova, Svetlana, Diana Paderina, Anastasiia Boiko, Olga Fedorenko, Ivan Pozhidaev, Vladimir Tigunsev, Elena Kornetova, Nikolay Bokhan, Bob Wilffert i Anton Loonen. "COMT gene polymorphism and antipsychotic- induced hyperprolactinemia in schizophrenia patients". W 2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB). IEEE, 2020. http://dx.doi.org/10.1109/csgb51356.2020.9214668.
Pełny tekst źródłaSurendran, R., i T. Tamilvizhi. "Cloud of medical things (CoMT) based smart healthcare framework for resource allocation". W 3rd Smart Cities Symposium (SCS 2020). Institution of Engineering and Technology, 2021. http://dx.doi.org/10.1049/icp.2021.0855.
Pełny tekst źródłaDong, Daiyun. "COMT, DRD1, DRD2, DRD4: Genetic evidence for the dopamine hypothesis in schizophrenia". W 7TH INTERNATIONAL CONFERENCE ON MATHEMATICS: PURE, APPLIED AND COMPUTATION: Mathematics of Quantum Computing. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0112965.
Pełny tekst źródłaValenzuela, Brayan, Isail Salazar i Fabio Martinez. "Lagrangian center of mass (CoMt) magnification to stand out main parkinsonian gait events". W 2019 XXII Symposium on Image, Signal Processing and Artificial Vision (STSIVA). IEEE, 2019. http://dx.doi.org/10.1109/stsiva.2019.8730254.
Pełny tekst źródłaNasr, Ali, i John McPhee. "Control-Oriented Muscle Torque (COMT) Model for EMG-Based Control of Assistive Robots". W The 7th International Conference of Control, Dynamic Systems, and Robotics. Avestia Publishing, 2020. http://dx.doi.org/10.11159/cdsr20.144.
Pełny tekst źródłaSmolnikova, Marina, i Sergey Tereshchenko. "Genetic association of the rs4680 COMT and rs1044396 CHRNA4 with internet addiction in Siberian adolescents". W 2020 Cognitive Sciences, Genomics and Bioinformatics (CSGB). IEEE, 2020. http://dx.doi.org/10.1109/csgb51356.2020.9214680.
Pełny tekst źródłaBlagosklonov, O., J. C. Cardot, C. Roux, T. Gharbi i P. Picart. "The First Experience of a Dedicated Biomedical Education Unit at the University of Franche-Comté". W 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1616419.
Pełny tekst źródłaLi, J., S. F. Jiang, H. Y. Chen, K. Liu, F. L. Niu i G. Z. Zhang. "A case-control study on 5 kinds of heavy metal, COMT genetic polymorphisms and risk of breast cancer". W International Conference on Environmental Science and Biological Engineering. Southampton, UK: WIT Press, 2014. http://dx.doi.org/10.2495/esbe140651.
Pełny tekst źródłaRaporty organizacyjne na temat "COMT"
Balut, Stephen J. Cost in Cost-Effectiveness. Fort Belvoir, VA: Defense Technical Information Center, lipiec 2002. http://dx.doi.org/10.21236/ada407699.
Pełny tekst źródłaFerreira, Douglas, i Claudia Costa. Impacto das condições atmosféricas em atividades da Vale ao longo do corredor Norte. ITV, 2020. http://dx.doi.org/10.29223/prod.tec.itv.ds.2020.38.ferreira.
Pełny tekst źródłaFonseca, William D'Andrea. Introdução ao LaTeX e como iniciar um novo projeto no Overleaf: Trabalho com acabamento profissional (diretamente em PDF). William D'Andrea Fonseca, lipiec 2020. http://dx.doi.org/10.55753/aev.v35e52.40.
Pełny tekst źródłaFachinelli, Ana Cristina, Cíntia Paese Giacomello, Bianca Libardi, Catiane Borsatto, Rafael de Lucena Perini, Suane de Atayde Moschen i Suélen Bebber. Perfil socioeconômico de Caxias do Sul 2021. UCS - Universidade de Caxias do Sul, czerwiec 2022. http://dx.doi.org/10.18226/9786500465075.
Pełny tekst źródłaMilligan, M., E. Ela, B. M. Hodge, B. Kirby, D. Lew, C. Clark, J. DeCesaro i K. Lynn. Cost-Causation and Integration Cost Analysis for Variable Generation. Office of Scientific and Technical Information (OSTI), czerwiec 2011. http://dx.doi.org/10.2172/1018105.
Pełny tekst źródłaGranderson, Jessica, Samir Touzani, Eliot Crowe, Samuel Fernandes, Shankar Earni i Kaiyu Sun. Realizing High-Accuracy Low-Cost Measurement and Verification for Deep Cost Savings (BPA Cost Share CRADA). Office of Scientific and Technical Information (OSTI), luty 2020. http://dx.doi.org/10.2172/1599182.
Pełny tekst źródłaChrispin, Thyeres Teixeira Bueno, Claudia Cristina Takano Novoa i Marair Gracio Ferreira Sartori. Dilatadores vaginais produzidos por impressora 3d para uso em Ginecologia. Universidade Federal de São Paulo., 2022. http://dx.doi.org/10.34024/agits20220002.
Pełny tekst źródłaHARTLEY, D. S. III, i S. L. PACKARD. OOTW COST TOOLS. Office of Scientific and Technical Information (OSTI), wrzesień 1998. http://dx.doi.org/10.2172/3095.
Pełny tekst źródłaSmith, Larry L. Cost Improvement Analysis. Fort Belvoir, VA: Defense Technical Information Center, czerwiec 1986. http://dx.doi.org/10.21236/ada200215.
Pełny tekst źródłaStrait, R. S. Cost analysis guidelines. Office of Scientific and Technical Information (OSTI), styczeń 1996. http://dx.doi.org/10.2172/219299.
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