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Rozprawy doktorskie na temat „Colorectal neoplasia”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Pye, G. "Gastrointestinal pH and colorectal neoplasia." Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381466.

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Kim, Sangmi Sandler Robert Samuel. "Obesity, inflammation and colorectal neoplasia." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,2164.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Feb. 26, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Epidemiology, School of Public Health." Discipline: Epidemiology; Department/School: Public Health.

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LaPointe, Lawrence C., and larry lapointe@flinders edu au. "Gene expression biomarkers for colorectal neoplasia." Flinders University. School of Medicine, 2009. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20091011.090028.

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The aim of this research was to assemble sufficient experimental evidence about candidate gene transcript expression changes between non-neoplastic and neo- plastic colorectal tissues to justify future assay development involving promis- ing leads. To achieve this aim, this thesis explores the hypothesis that gene expression-based biomarkers can be used to accurately discriminate colorectal neoplastic tissues from non-neoplastic controls. This hypothesis was tested by first analysing multiple, large, quality controlled data sets comprising gene expression measurements across colorectal phenot

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Bhaskar, P. "Molecular mechanisms of colorectal neoplasia in acromegaly." Thesis, University of Newcastle upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405070.

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Hubner, Richard Anthony. "Low penetrance polymorphisms and colorectal neoplasia susceptibility." Thesis, Institute of Cancer Research (University Of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499095.

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Liu, Lin, Karen Messer, John A. Baron, et al. "A prognostic model for advanced colorectal neoplasia recurrence." SPRINGER, 2016. http://hdl.handle.net/10150/621531.

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Following colonoscopic polypectomy, US Multisociety Task Force (USMSTF) guidelines stratify patients based on risk of subsequent advanced neoplasia (AN) using number, size, and histology of resected polyps, but have only moderate sensitivity and specificity. We hypothesized that a state-of-the-art statistical prediction model might improve identification of patients at high risk of future AN and address these challenges. Data were pooled from seven prospective studies which had follow-up ascertainment of metachronous AN within 3-5 years of baseline polypectomy (combined n = 8,228). Pooled data

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7

Parra, del Riego A., Sparks A. Olivares, B. F. Barreda, and Nilton Yhuri Carreazo. "Advanced colorectal neoplasia: The importance of adequate classification." Asociación Mexicana de Gastroenterología, 2016. http://hdl.handle.net/10757/605890.

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Botteri, E. "IMPACT OF LIFESTYLE FACTORS ON SCREENING-DETECTED COLORECTAL NEOPLASIA." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/215071.

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Background and aims: The detection and removal of precancerous lesions through colorectal cancer (CRC) screening, and the intervention on modifiable risk factors for CRC - such as smoking habits, physical activity, red meat consumption and alcohol intake - represent the two possible ways for reducing CRC incidence and mortality. The aim of this project was to investigate whether lifestyle factors, gender, family history and daily low-dose Aspirin use are important factors in predicting endoscopy findings at a first round screening level and whether they can have a significant impact on the nat

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9

Basso, G. "MOLECULAR HETEROGENEITY AND PROGNOSTIC IMPLICATIONS OF SYNCHRONOUS ADVANCED COLORECTAL NEOPLASIA." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/222721.

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Introduzione e scopo. In letteratura molte ipotesi sono state formulate sull’insorgenza dei tumori sincroni del colon retto (S-CRC). Infatti, non è ancora del tutto chiaro se questo tipo di malattia sviluppa attraverso un particolare pathway molecolare legato ad una elevata suscettibilità della mucosa colica a divenire neoplastica e se a livello clinico evidenzia una prognosi peggiore. Dal momento che i tumori con instabilità dei microsatelliti (MSI) possono costituire un bias nel valutare la presenza di metilazione e l’andamento clinico dei S-CRC, abbiamo analizzato per neoplasia sincrona e p

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Sardo, Christine Louise. "The Biological Role of Fruit Phenolics, Sedentary Behavior, and Inflammation on Colorectal Neoplasia." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/297045.

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Background: Clinical and epidemiologic studies have investigated the effects of diet, physical activity, and inflammation on the risk of colorectal adenoma occurrence and recurrence. Inflammation has been proposed as a mechanism of action for the development of colorectal adenoma and cancer. Research indicates that fruit phenolic exposure may attenuate the inflammatory response and some data suggest that berries are effective in mitigating this process. Inflammatory cytokines such as interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor alpha (TNF-α) are of particular in

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11

Wong, Justin Jong Leong Medical Sciences Faculty of Medicine UNSW. "The role of DNA methylation in the development of colorectal neoplasia." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/43359.

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DNA methylation is increasingly recognised as a significant epigenetic event that may initiate and drive the process of neoplasia in humans. In the colon, DNA methylation of key genes is common in a subset of colorectal cancers. The extent to which DNA methylation at various genes contributes to initiation of colorectal neoplasms is less clear. This study sought to clarify the biological and clinicopathological significance of methylation of various genes in the development of sporadic and familial colorectal neoplasia. Quantitative methylation-specific PCR (qMSP) assays (capable of detecting

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12

Ibrahim, A. E. K. "The role of DNA methylation in the progression of colorectal neoplasia." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604918.

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I optimized a microarray method for identifying genome-wide CpG island methylation changes called Microarray-based Methylation Assessment of Single Samples (MMASS). A prospective sample set of matched normal colorectal mucosa, adenoma and adenocarcinoma tissues were collected as well as a retrospective set of primary colorectal carcinomas and where present their metastatic tissues. All cases were assayed for microsatellite instability. Genome-wide methylation patterns were profiled using MMASS and were correlated with their corresponding genome-wide expression changes for a subset of the cases

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13

Moorehead, Robert John. "A study of some aspects of the pathogenesis of colorectal neoplasia." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328030.

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Clark, Andrew J. E. "Investigation of mutant DNA in plasma of patients with colorectal neoplasia." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/24459.

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Introduction: Colorectal cancer is a major clinical and public health problem. Early stage colorectal cancer is amenable to surgical intervention with a high cure rate. Screening for the disease has now been rolled out throughout the UK, although current screening modality of faecal occult blood testing (FOBT) is suboptimal. Specific genetic alterations found in primary tumours, including mutations in proto-oncogenes, microsatellite instability and loss of heterozygosity (LOH), have been shown to be detectable in the host plasma. Colorectal cancer is an excellent paradigm in which to investiga

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15

Khoo, Kong Kheong. "The influence of metabolic phenotypes upon the development of colorectal neoplasia /." Title page, table of contents and conclusions only, 1995. http://web4.library.adelaide.edu.au/theses/09MD/09mdk45.pdf.

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16

Will, Olivia Constance Claire. "The initiation and progression of neoplasia in inherited and sporadic colorectal cancer." Thesis, Queen Mary, University of London, 2009. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1651.

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This dissertation describes investigations into aspects of neoplastic initiation and progression in the gut, in the context of inherited and sporadic gastrointestinal cancer. In familial adenomatous polyposis, there is marked locoregional variation in polyp density. This work investigated the relationship between gut location and somatic inactivation of APC. It demonstrated that the frequency of APC loss of heterozygosity (LOR) varied along the colon, suggesting a colonic gradient in "just right" signalling. It investigated adenomas of the ileoanal pouch, where small bowel functions as rectum.

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17

Lee, Thomas Jonathan William. "Detection and management of colorectal neoplasia in the NHS bowel cancer screening programme." Thesis, University of Newcastle Upon Tyne, 2012. http://hdl.handle.net/10443/1783.

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Background Screening for colorectal cancer aims to reduce mortality by detecting cancer at an earlier stage. The NHS Bowel Cancer Screening Programme (BCSP) offers faecal occult blood testing (FOBt) followed by colonoscopy for those with a positive FOBt. This thesis examines the detection and management of colorectal neoplasia in the BCSP. Aims and Methods 1. Explore adenoma detection rate (ADR) as a measure of colonoscopic performance and examine which factors influence adenoma detection rate by analysing data gathered from the BCSP. 2. Describe the findings at 12 month surveillance colonosco

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18

Basavaraju, Umesh. "Inflammatory biomarkers of colorectal neoplasia and their manipulation by an anti-inflammatory diet." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=182290.

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Colorectal neoplasia (CRN) continues to be a leading cause of morbidity and mortality in the developed world and with westernisation, similar trends are now emerging in the developing world. Although secondary prevention through screening programmes has reduced mortality, uptake remains poor due to the invasive nature of colonoscopy, which also exerts increased costs to the health care system. Primary prevention remains the ultimate aim to reduce the morbidity and mortality associated with CRN. In this regard, chemoprevention strategies through regular use of aspirin and other NSAIDS have show

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19

Mitrou, Panagiota N. "Genetic polymorphisms in NQ01, mEH and MTHFR, environmental factors and sporadic colorectal neoplasia." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615633.

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Egan, Jan Bailey. "Evaluating the Role of VDR Polymorphisms and Beta-catenin Signaling in Colorectal Neoplasia." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/195709.

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Colorectal cancer is estimated to cause approximately 50,000 deaths each year in the United States. Epidemiological studies have demonstrated an inverse association between sunlight exposure, which stimulates the formation of vitamin D in the skin, and colorectal carcinoma. Laboratory studies report that metabolites of vitamin D, acting through the vitamin D receptor (VDR), regulate cellular proliferation, differentiation and apoptosis. In addition, VDR contains a polymorphic variant, FokI, which results in two different isoforms of VDR. We have demonstrated a differential suppression of β-cat

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21

Quirke, P. "The role of flow cytometry in the assessment of the pathobiology of colorectal neoplasia." Thesis, University of Leeds, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384672.

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Tafner, Edmar. "A colonoscopia com e sem auxílio de métodos de cromoscopia no diagnóstico das lesões planas, deprimidas e elevadas do cólon e reto." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-15062011-145410/.

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O câncer colorretal (CCR) é uma das maiores causas de óbito no mundo industrializado, com uma incidência anual de 800.000 casos novos, o que significa 8,5% de todos os novos e 12% das mortes relacionadas a essa doença. No Brasil, excluindo-se os cânceres de pele não melanoma, o CCR é o quarto mais freqüente entre os homens e o terceiro entre as mulheres. O risco de desenvolver CCR é de aproximadamente 5% a 6% na população ocidental. Existem evidências epidemiológicas de redução do CCR em 60% -90% quando a colonoscopia com polipectomia é usada preventivamente A colonoscopia ainda é o melhor mét

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23

Silva, Ana Luísa Brás Dos Santos Ribeiro. "Identification of differentially methylated genes as potential biomarkers for the early detection of colorectal neoplasia." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610752.

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Hartley, John Edward. "An evaluation of the use of laparoscopic techniques for the resection of colorectal carcinoma." Thesis, University of Hull, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322452.

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Brauer, Paula Mae. "Familial aggregation of diabetes, hypertension and cardiovascular conditions in a case-control study of colorectal neoplasia." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0023/NQ49836.pdf.

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Aslam, Muhammad Imran. "MicroRNAs are novel biomarkers for the detection of colorectal neoplasia and high risk Dukes' B cancers." Thesis, University of Leicester, 2016. http://hdl.handle.net/2381/37943.

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Aims: This study aimed to identify which circulating miRNAs can be used for the early detection of colorectal cancers (CRCs) and to assess the utility of tissue miRNAs combined with common gene mutations, to predict the development of metastasis in patients with Dukes’ B CRCs. Methods: microRNA (miRNA) expression profiling was performed for total RNA extracted from plasma samples (colonoscopy negative controls=11, adenomas=9, carcinomas=12) and formalin-fixed paraffin embedded (FFPE) matched paired cancerous with adjacent normal tissue (n=20, 5 cases from each group of Dukes’ A, Dukes’ B with

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Hibler, Elizabeth Anne. "Genetic and Environmental Factors Influencing Circulating Concentration of Vitamin D Metabolites and Odds of Colorectal Neoplasia." Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/145300.

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Circulating concentrations of vitamin D metabolites are associated with risk for a variety of diseases, including colorectal cancer. It is not known what level of circulating 25(OH)D is optimal for health; however, over-the-counter (OTC) vitamin D supplements are commonly used to improve status, though their effectiveness is unknown. It is also not known if polymorphic variation in genes associated with the vitamin D endocrine system is associated with differences in vitamin D metabolite levels or colorectal neoplasia.METHODS: A double-blind, randomized, placebo-controlled trial examined the e

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Bessa, Caserras Xavier. "Interacció leucòcit-endoteli i mobilització de cèl·lules neoplàsiques en el càncer colorectal." Doctoral thesis, Universitat de Barcelona, 2003. http://hdl.handle.net/10803/2161.

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El procés de disseminació metastàsic en el càncer colorectal és un procés complex multifactorial. La present tesi ha pretès aprofundir en dos aspectes: els mecanismes de defensa immunològic a través de la caracterització dels fenòmens de interacció leucocitària, i el procés de mobilització tumoral a través de la detecció i pronòstic de les cèl·lules neoplàsiques circulants.<br/>En la present tesi s'ha confirmat que existeix una deficient interacció dels leucòcits circulants amb l'endoteli dels vasos tumorals respecte a l'endoteli no tumoral, tant de rodament en condicions basals com d'adhes

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Bessa, Caserras Xavier. "Interacció leucòcit-endoteli i mobilització de cèl.lules neoplàsiques en el càncer colorectal." Doctoral thesis, Universitat de Barcelona, 2003. http://hdl.handle.net/10803/2161.

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El procés de disseminació metastàsic en el càncer colorectal és un procés complex multifactorial. La present tesi ha pretès aprofundir en dos aspectes: els mecanismes de defensa immunològic a través de la caracterització dels fenòmens de interacció leucocitària, i el procés de mobilització tumoral a través de la detecció i pronòstic de les cèl·lules neoplàsiques circulants.En la present tesi s'ha confirmat que existeix una deficient interacció dels leucòcits circulants amb l'endoteli dels vasos tumorals respecte a l'endoteli no tumoral, tant de rodament en condicions basals com d'adhesió re

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Sigglekow, Nicholas David Garvan Institute of Medical Research Faculty of Medicine UNSW. "Mutated in colorectal cancer (MCC): a putative tumour suppressor gene in colorectal cancer." Publisher:University of New South Wales. Garvan Institute of Medical Research, 2009. http://handle.unsw.edu.au/1959.4/43617.

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Colorectal cancer (CRC) remains a significant burden in contemporary society due to an aging population, unhealthy dietary choices and an increasingly sedentary lifestyle. While the underlying defects for many hereditary forms of CRC have been determined, many genetic and epigenetic changes promoting common sporadic CRCs have yet to be identified. The Mutated in Colorectal Cancer (MCC) gene, identified in 1991, was initially thought to be responsible for the hereditary form of CRC, familial adenomatous polyposis, before the discovery of the susceptibility gene Adenomatous Polyposis Coli (APC),

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Allison, Andrew S. "The insulin-like growth factor type 1 receptor and colorectal neoplasia : modelling the somatic evolution of cancers." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/26957.

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This thesis examines the temporal expression of the Insulin-like growth factor type 1 receptor gene (IGF-IR) in the evolution of human colon cancer. These studies examine IGF-1R expression in human colo-rectal neoplasia by means of Northern blotting and Immunohistochemistry validated by tissue and reagent controls and by Western blotting. The studies show that in the normal human colon, adult stem cells in the basal crypt region expression high IGF-1R levels which decrease to low levels when these cells migrate to and differentiate in the mid and upper crypt regions. In the aberrant crypt focu

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Digby, Jayne. "The relationship between faecal haemoglobin concentration and risk of significant colorectal neoplasia in screening and symptomatic populations." Thesis, University of Dundee, 2016. https://discovery.dundee.ac.uk/en/studentTheses/278e46d6-762b-4a0e-a2cc-3a3cbf475d52.

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Faecal immunochemical tests for haemoglobin (FIT) are replacing traditional guaiac-based faecal occult blood (gFOBT) tests in bowel screening programmes due to their many advantages. An evaluation of using quantitative FIT within the Scottish Bowel Screening Programme (SBSP) has taken place with faecal haemoglobin (Hb) concentration recorded for 38,720 participants. Subsequently, it has been established that faecal Hb concentration is related to severity of colorectal neoplastic disease, with higher median faecal Hb concentration in participants with advanced neoplasia compared to those with l

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SANTOS, Alex Caetano dos. "Aspectos clínicos e patológicos de pacientes com tumores colorretais diagnosticados durante cirurgia abdominal de urgência." Universidade Federal de Goiás, 2011. http://repositorio.bc.ufg.br/tede/handle/tde/1732.

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Made available in DSpace on 2014-07-29T15:29:11Z (GMT). No. of bitstreams: 1 Dissertacao Alex Caetano dos Santos.pdf: 982242 bytes, checksum: f685e405b1e872acdf53a2790d29d70b (MD5) Previous issue date: 2011-04-25<br>Context In 85% of the cases, colorectal cancer is diagnosed at an advanced stage during investigation of symptomatic patients. Currently, 10% to 33% of the cases may present emergency situations (obstruction or perforation), requiring immediate surgical treatment, and may result in higher mortality compared with elective surgical procedures. Objective Analyze clinical and pat

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Watson, Mark Alexander. "Inter-individual variation in susceptibility to colorectal neoplasia : the interaction between diet, measures of DNA damage and genetic polymorphisms." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404833.

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Banu, Nahida Arjumand. "The role of selective cyclooxygenase-2 inhibitor NS398 in the regulation of cell adhesion and cell migration in colorectal neoplasia." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404309.

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Gruppo, Mario. "Subclinical myopathy and colorectal cancer: identification and role of new muscle damage and regeneration biomarkers." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424623.

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Background Skeletal muscle is the major reservoir of body proteins and it can be affected in conditions associated to altered protein turnover and metabolism such as cancer. Although severe wasting is seen primarily in patients with advanced malignancy, some of them present degree of wasting at the onset of disease. Autophagy has been recently described to play a relevant role in muscle wasting. Materials and Methods We performed morphometric studies and immunohistochemical analyses on intraoperative rectus abdominis muscle biopsies from 50 consecutive weight stable colorectal patients and

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Hanks, Joanna. "The influence of the MTHFR C677T genotype and folate status on genomic DNA methylation and uracil misincorporation in the colon of subjects without colorectal neoplasia." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/the-influence-of-the-mthfr-c677t-genotype-and-folate-status-on-genomic-dna-methylation-and-uracil-misincorporation-in-the-colon-of-subjects-without-colorectal-neoplasia(4175b8e8-1b3d-4dbc-99eb-a3badc61f907).html.

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Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality in the UK. Folate deficiency and the MTHFR C677T polymorphism may increase colorectal cancer risk by altering normal patterns of DNA methylation and by causing uracil misincorporation into DNA which can in turn induce deletions and double-strand breaks. The methylenetetrahydrofolate reductase (MTHFR) enzyme is pivotal in maintaining the balance between these two critical folate-mediated pathways (DNA methylation and uracil misincorporation) and the commonly occurring MTHFR C667T polymorphism has been associated

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Pinheiro, Rafael Soares Nunes. "Avaliação das margens cirúrgicas e do tipo de borda tumoral nas ressecções hepáticas por metástase de câncer colorretal e seu impacto na mortalidade e recidiva." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5154/tde-09082012-143141/.

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INTRODUÇÃO: Aproximadamente 50% dos pacientes com tumor colorretal apresentam metástase hepática e a hepatectomia é o procedimento terapêutico de escolha. Discutem-se diversos fatores prognósticos, entre eles a margem cirúrgica é um fator sempre recorrente, pois não existe consenso da distância mínima necessária entre o nódulo metastático e a linha de secção hepática. Alguns autores identificaram que a margem cirúrgica maior que 1cm é um fator de melhor prognóstico com maior sobrevida e menor recidiva. Contudo, outros estudos demonstram resultados semelhantes entre pacientes com margens cirúrg

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Majumdar, Debabrata. "Expression and post-translational modification of intermediate filament proteins in colonic mucosa of patients with ulcerative colitis : role in pathogenesis of colitis associated colorectal neoplasia and dysplasia." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/16564/.

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Background: Ulcerative colitis(UC) is a chronic inflammatory disease of the colon associated with increased cancer risk of colitis associated cancer(CAC). Keratins(K) are intermediate filament(IF) proteins, and are key component of the cellular cytoskeleton. K8 null mice develop colitis; a subset of IBD patients have mutation in K8 gene. Keratins play a role in cell-death signalling pathways; epithelial cells lacking K8 and K18 are more sensitive to TNF-mediated apoptosis. Methods: Colonic biopsies obtained from UC patients (and controls) were grouped into eight categories based on risk of can

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Marques, Carlos Frederico Sparapan. "Tratamento da neoplasia retal pela microcirurgia endoscópica transanal- TEM: fatores de risco para complicações pós-operatórias." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-29102014-155628/.

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INTRODUÇÃO: A microcirurgia endoscópica transanal (TEM) é uma técnica minimamente invasiva segura e eficiente para o tratamento de neoplasia retal benigna e maligna precoce. As complicações pós operatórias podem ser graves. Existe controvérsia na literatura a respeito da sua incidência e gravidade. OBJETIVOS: Avaliar os fatores de risco relacionados a incidência e gravidade das complicações pós operatórias e seu comportamento temporal em pacientes com neoplasia retal tratados por TEM. MÉTODOS: Estudo prospectivo das complicações pós-operatórias usando a classificação e graduação de Clavien-Din

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Jansson, Agneta. "Molecular alterations in colorectal cancer /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/med743s.pdf.

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Boetto, Riccardo. "Extreme hepatectomies and non-resectability technical breakthrough for liver neoplasia, focusing on colorectal metastases: experimental pilot study on safety, efficacy, and regeneration patterns with new insight on ALLPS-LT hybrid techniques." Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3426225.

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BACKGROUND New strategies to broaden resectability criteria in hepatobiliary surgery has led to the development of two-stage hepatectomy techniques, multi-step procedures with the aim of promoting effective regeneration of the future liver residue (FLR). The first multicentre international case study was published in 2012 for a new surgical technique defined ALPPS (Associating Liver partition and Portal vein ligation for Staged hepatectomy), which implies in Step1 (laparotomy) ligation of the right portal branch (PVL) with subtotal parenchymal transection (in situ splitting), in order to sti

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Malieno, Paula Braz. "Avaliação sensitiva de doentes com câncer colorretal tratados com oxaliplatina." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-05012017-163025/.

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A avaliação sensitiva de pacientes tratados com oxaliplatina tem se tornado objeto de estudo, pelo fato deste medicamento causar como efeito colateral, uma neuropatia periférica com características sensitivas, imediatamente após início da infusão. Sintomas que causam restrições nas atividades de vida diárias e na qualidade de vida do paciente durante o tratamento. Para uma melhor compreensão do mecanismo das alterações sensitivas, atualmente tem se utilizado o teste quantitativo da sensibilidade (TQS), que através da mensuração quantitativa dos limiares de detecção aos estímulos quente, frio e

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Dahl, Kjell. "Human colorectal cancer : experimental staging and therapeutics /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-154-8/.

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Gudzuhn, Andrej. "Virulenzfaktoren von E.coli aus gewaschenen Kolonbiopsien von Patienten mit kolorektalen Neoplasien." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/15059.

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Hintergrund: Die Pathogenese nicht-familiärer kolorektaler Neoplasien ist heute noch nicht bekannt. Die Besonderheiten der Epidemiologie der Erkrankung sprechen für die Beteiligung von Umweltfaktoren, wie sozioökonomischer Faktoren, der Ernährung oder der bakteriellen Flora des Darmes. Eine intrazelluläre, von E.coli dominierte Flora wurde in Kolonbiopsien dieser Patienten beschrieben. Methoden: Es wurden Virulenzfaktoren von Escherichia coli untersucht, die aus gewaschenen koloskopischen Biopsien von 43 Patienten mit kolorektalen Adenomen und Karzinomen isoliert worden waren. 100 Stämme wur

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Habermann, Jens Karsten. "Colorectal cancer : genome, transcriptome, and proteome dynamics /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-411-2/.

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Fontana, Rafael. "Resultados do tratamento cirúrgico e de estudo dos fatores prognósticos de sobrevida em pacientes com metástases hepáticas sincrônicas do câncer de cólon e reto." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5154/tde-13062011-150536/.

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O câncer colorretal (CCR) é a neoplasia mais prevalente no mundo e, cerca de 60% apresentarão metástases hepáticas, representando uma importante causa de mortalidade. Aproximadamente 35% dos pacientes apresentam metástases hepáticas no momento do diagnóstico do tumor primário ou desenvolverão metástases durante o primeiro ano após o tratamento da neoplasia colorretal, conhecidas como metástases sincrônicas. Inúmeros trabalhos têm demonstrado que as metástases sincrônicas representam importante fator prognóstico negativo na evolução destes pacientes, representando um grupo de pacientes que nece

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An, Zhengwen. "Integrin-interacting proteins in human cancer progression." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-877-8/.

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Araujo, Raphael Leonardo Cunha de. "Análise comparativa da sobrevida entre pacientes submetidos à cirurgia exclusiva ou associada à quimioterapia para o tratamento de metástases hepáticas de câncer colorretal: revisão sistemática e meta-análise." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-01042015-112159/.

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Introdução: A ressecão hepática é considerada um tratamento potencialmente curativo para metástases hepáticas de câncer colorretal (MHCCR), mas os benefícios a longo prazo oferecidos pela complementação do tratamento com quimioterapia sistêmica não foram completamente comprovados. Existe ganho já bem estabelecido para sobrevida livre de doença com o uso de quimioterapia perioperatória, mas não existe ganho de sobrevida global demonstrado em ensaios clínicos randomizados (ECR). Objetivo: Comparar sobrevida global e livre de doença em pacientes com MHCCR submetidos apenas ao tratamento cirúrgico

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Williams, Alistair Robert William. "Expression of oncogenes in human colorectal neoplasms." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/19415.

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