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Artykuły w czasopismach na temat „Code with t-availability”

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Data publikacji: 6 września 2023

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1

Lu, Yanbo, Xinji Liu, and Shutao Xia. "On the Single-Parity Locally Repairable Codes with Multiple Repairable Groups." Information 9, no. 11 (2018): 265. http://dx.doi.org/10.3390/info9110265.

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Locally repairable codes (LRCs) are a new family of erasure codes used in distributed storage systems which have attracted a great deal of interest in recent years. For an [ n , k , d ] linear code, if a code symbol can be repaired by t disjoint groups of other code symbols, where each group contains at most r code symbols, it is said to have availability- ( r , t ) . Single-parity LRCs are LRCs with a constraint that each repairable group contains exactly one parity symbol. For an [ n , k , d ] single-parity LRC with availability- ( r , t ) for the information symbols (single-parity LRCs), th
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Häkkinen, Antti, Juha Koiranen, Julia Casado, et al. "qSNE: quadratic rate t-SNE optimizer with automatic parameter tuning for large datasets." Bioinformatics 36, no. 20 (2020): 5086–92. http://dx.doi.org/10.1093/bioinformatics/btaa637.

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Abstract Motivation Non-parametric dimensionality reduction techniques, such as t-distributed stochastic neighbor embedding (t-SNE), are the most frequently used methods in the exploratory analysis of single-cell datasets. Current implementations scale poorly to massive datasets and often require downsampling or interpolative approximations, which can leave less-frequent populations undiscovered and much information unexploited. Results We implemented a fast t-SNE package, qSNE, which uses a quasi-Newton optimizer, allowing quadratic convergence rate and automatic perplexity (level of detail)
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Galletly, G. D., and J. Błachut. "Torispherical Shells under Internal Pressure—Failure due to Asymmetric Plastic Buckling or Axisymmetric Yielding." Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science 199, no. 3 (1985): 225–38. http://dx.doi.org/10.1243/pime_proc_1985_199_117_02.

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In the diameter-to-thickness range 250 < D/t < 1000, internally pressurized torispherical shells can fail either by plastic buckling or by axisymmetric yielding. However, the present Code rules cater only for the axisymmetric yielding mode and they also restrict the D/t ratios to being less than 500. The rules are based on limit analysis results and these can be conservative for this problem. With regard to internal pressure buckling, there are as yet no design rules in either the American or the British pressure vessel Codes to prevent its occurrence. To provide guidance for a more accu
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Rega, Paul, Shaun Vallejo, John Accumanno, and Brian Fink. "The Integration of a Unique QR® Code and Video to Improve the Correct Application of a Hemorrhage-control Tourniquet by a Naïve Population - A Feasibility Study." Prehospital and Disaster Medicine 34, s1 (2019): s142. http://dx.doi.org/10.1017/s1049023x19003145.

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Introduction:The use of tourniquets by the civilian population has been deemed a critical aspect of the initial response during an active shooter situation. Tourniquet deployment in public-access must be accompanied by education. Studies indicate that the act itself is not an intuitive process and enclosed instructions may be inadequate. However, civilians for diverse reasons may not avail themselves of accepted training programs.Aim:To develop an alternative means of “Just-In-Time” education to enable a naïve responder to apply a commercial tourniquet efficaciously.Methods:A video (~40 second
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Sturm, Gregor, Tamas Szabo, Georgios Fotakis, et al. "Scirpy: a Scanpy extension for analyzing single-cell T-cell receptor-sequencing data." Bioinformatics 36, no. 18 (2020): 4817–18. http://dx.doi.org/10.1093/bioinformatics/btaa611.

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Abstract Summary Advances in single-cell technologies have enabled the investigation of T-cell phenotypes and repertoires at unprecedented resolution and scale. Bioinformatic methods for the efficient analysis of these large-scale datasets are instrumental for advancing our understanding of adaptive immune responses. However, while well-established solutions are accessible for the processing of single-cell transcriptomes, no streamlined pipelines are available for the comprehensive characterization of T-cell receptors. Here, we propose single-cell immune repertoires in Python (Scirpy), a scala
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6

Tyagi, Ruchi, and Suresh Vishwakarma. "Prospect of low-cost energy conservation in residential energy consumption." International Journal of Power Electronics and Drive Systems (IJPEDS) 12, no. 4 (2021): 2403. http://dx.doi.org/10.11591/ijpeds.v12.i4.pp2403-2413.

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The energy sector of trinidad and tobago (T&T), with its nationally determined contributions (NDCs), is still struggling for its place in mainstream academic literature. The review paper aims to identify the prospects of low-cost energy conservation measures in the residential sector of T&T. The review follows a four-step review methodology to serve as a basis for creating policy and practice guidelines. First, review articles are checked for their quality on a 5-point scale on the mixed methods appraisal tool (MMAT) to check the quality of review articles. Second, Microsoft Ex
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7

Hoot, Bradley, and Shane Ebert. "The That-Trace Effect: Evidence from Spanish–English Code-Switching." Languages 6, no. 4 (2021): 189. http://dx.doi.org/10.3390/languages6040189.

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The that-trace effect is the fact that many languages (like English) ban the extraction of embedded-clause subjects but not objects over an overt complementizer like that, while many other languages (like Spanish) allow such extractions. The effect and its cross-linguistic variation have been the subject of intense research but remain largely a mystery, with no clear consensus on their underpinnings. We contribute novel evidence to these debates by using Spanish–English code-switching (the use of two languages in one sentence) to test five contemporary theoretical accounts of the that-trace ef
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8

Aliverti, Emanuele, Jeffrey L. Tilson, Dayne L. Filer, et al. "Projected t-SNE for batch correction." Bioinformatics 36, no. 11 (2020): 3522–27. http://dx.doi.org/10.1093/bioinformatics/btaa189.

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Abstract Motivation Low-dimensional representations of high-dimensional data are routinely employed in biomedical research to visualize, interpret and communicate results from different pipelines. In this article, we propose a novel procedure to directly estimate t-SNE embeddings that are not driven by batch effects. Without correction, interesting structure in the data can be obscured by batch effects. The proposed algorithm can therefore significantly aid visualization of high-dimensional data. Results The proposed methods are based on linear algebra and constrained optimization, leading to
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9

Isacchini, Giulio, Carlos Olivares, Armita Nourmohammad, Aleksandra M. Walczak, and Thierry Mora. "SOS: online probability estimation and generation of T-and B-cell receptors." Bioinformatics 36, no. 16 (2020): 4510–12. http://dx.doi.org/10.1093/bioinformatics/btaa574.

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Abstract Summary Recent advances in modelling VDJ recombination and subsequent selection of T- and B-cell receptors provide useful tools to analyse and compare immune repertoires across time, individuals and tissues. A suite of tools—IGoR, OLGA and SONIA—have been publicly released to the community that allow for the inference of generative and selection models from high-throughput sequencing data. However, using these tools requires some scripting or command-line skills and familiarity with complex datasets. As a result, the application of the above models has not been available to a broad au
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10

Alonsozana, G. L., and R. H. Christenson. "The case for cardiac troponin T: marker for effective risk stratification of patients with acute cardiac ischemia." Clinical Chemistry 42, no. 5 (1996): 803–8. http://dx.doi.org/10.1093/clinchem/42.5.803.

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Abstract Availability of markers such as cardiac troponin T (cTnT) has brought new insights into ischemic heart disease (IHD). cTnT is a distinct protein that differs from other markers in biological function, molecular mass, and cytosolic pool. cTnT has been utilized for diagnosis of acute myocardial infarction (AMI) and risk stratification of patients with IHD. For AMI diagnosis, cTnT showed high sensitivity (94-100%) but generally lower specificity (46-99%), possibly because of increases in non-AMI patients with minor myocardial damage. Outcome studies have demonstrated that IHD patients wi
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11

O’Connor, Timothy, Charles E. Grant, Mikael Bodén, and Timothy L. Bailey. "T-Gene: improved target gene prediction." Bioinformatics 36, no. 12 (2020): 3902–4. http://dx.doi.org/10.1093/bioinformatics/btaa227.

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Abstract Motivation Identifying the genes regulated by a given transcription factor (TF) (its ‘target genes’) is a key step in developing a comprehensive understanding of gene regulation. Previously, we developed a method (CisMapper) for predicting the target genes of a TF based solely on the correlation between a histone modification at the TF’s binding site and the expression of the gene across a set of tissues or cell lines. That approach is limited to organisms for which extensive histone and expression data are available, and does not explicitly incorporate the genomic distance between th
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12

Culbertson, Adam, Satyender Goel, Margaret Madden, et al. "The Building Blocks of Inter-operability." Applied Clinical Informatics 08, no. 02 (2017): 322–36. http://dx.doi.org/10.4338/aci-2016-11-ra-0196.

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SummaryBackground: Patient matching is a key barrier to achieving interoperability. Patient demographic elements must be consistently collected over time and region to be valuable elements for patient matching.Objectives: We sought to determine what patient demographic attributes are collected at multiple institutions in the United States and see how their availability changes over time and across clinical sites.Methods: We compiled a list of 36 demographic elements that stakeholders previously identified as essential patient demographic attributes that should be collected for the purpose of l
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13

Sethna, Zachary, Yuval Elhanati, Curtis G. Callan, Aleksandra M. Walczak, and Thierry Mora. "OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs." Bioinformatics 35, no. 17 (2019): 2974–81. http://dx.doi.org/10.1093/bioinformatics/btz035.

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Abstract Motivation High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and B-cell receptors of any specific nucleotide sequence. These generation probabilities are very non-homogeneous, ranging over 20 orders of magnitude in real repertoires. Since the function of a receptor really depends on its protein sequence, it is important to be able to predict this probability of generation at the amino acid level. However, brute-force summation over all the nucleotide sequences with the cor
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14

Tran, Stephen S., Qing Zhou, and Xinshu Xiao. "Statistical inference of differential RNA-editing sites from RNA-sequencing data by hierarchical modeling." Bioinformatics 36, no. 9 (2020): 2796–804. http://dx.doi.org/10.1093/bioinformatics/btaa066.

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Abstract Motivation RNA-sequencing (RNA-seq) enables global identification of RNA-editing sites in biological systems and disease. A salient step in many studies is to identify editing sites that statistically associate with treatment (e.g. case versus control) or covary with biological factors, such as age. However, RNA-seq has technical features that incumbent tests (e.g. t-test and linear regression) do not consider, which can lead to false positives and false negatives. Results In this study, we demonstrate the limitations of currently used tests and introduce the method, RNA-editing tests
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15

Wait, Eric, Mark Winter, and Andrew R. Cohen. "Hydra image processor: 5-D GPU image analysis library with MATLAB and python wrappers." Bioinformatics 35, no. 24 (2019): 5393–95. http://dx.doi.org/10.1093/bioinformatics/btz523.

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Abstract Summary Light microscopes can now capture data in five dimensions at very high frame rates producing terabytes of data per experiment. Five-dimensional data has three spatial dimensions (x, y, z), multiple channels (λ) and time (t). Current tools are prohibitively time consuming and do not efficiently utilize available hardware. The hydra image processor (HIP) is a new library providing hardware-accelerated image processing accessible from interpreted languages including MATLAB and Python. HIP automatically distributes data/computation across system and video RAM allowing hardware-acc
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16

Weber, Anna, Jannis Born, and María Rodriguez Martínez. "TITAN: T-cell receptor specificity prediction with bimodal attention networks." Bioinformatics 37, Supplement_1 (2021): i237—i244. http://dx.doi.org/10.1093/bioinformatics/btab294.

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Abstract Motivation The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing of TCRs and their antigenic targets (epitopes), allowing to research the missing link between TCR sequence and epitope binding specificity. Scarcity of data and a large sequence space make this task challenging, and to date only models limited to a small set of epitopes have achieved good performance. Here, we establish a k-nearest-neighbor (K-NN) classifi
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17

Ahmed, Syed Faraz, Ahmed A. Quadeer, David Morales-Jimenez, and Matthew R. McKay. "Sub-dominant principal components inform new vaccine targets for HIV Gag." Bioinformatics 35, no. 20 (2019): 3884–89. http://dx.doi.org/10.1093/bioinformatics/btz524.

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Abstract Motivation Patterns of mutational correlations, learnt from patient-derived sequences of human immunodeficiency virus (HIV) proteins, are informative of biochemically linked networks of interacting sites that may enable viral escape from the host immune system. Accurate identification of these networks is important for rationally designing vaccines which can effectively block immune escape pathways. Previous computational methods have partly identified such networks by examining the principal components (PCs) of the mutational correlation matrix of HIV Gag proteins. However, driven by
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18

Zimmerman Savill, Kristin M., Andrew J. Klink, Djibril Liassou, Dhruv Chopra, Jalyna Laney, and Ajeet Gajra. "Real-World Treatment of Patients with Large B-Cell Lymphoma in the United States with Chimeric Antigen Receptor T-Cell Therapy." Blood 138, Supplement 1 (2021): 4096. http://dx.doi.org/10.1182/blood-2021-150723.

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Abstract Introduction: The advent of chimeric antigen receptor (CAR) T-cell therapy has represented one of the most innovative therapeutic advances in oncology in recent years. Impressive clinical responses to CAR T-cell therapy observed in patients in clinical trials have led to the Food and Drug Administration (FDA) approval of five CAR T-cell therapies in the US since 2017 to treat large B-cell, mantle cell, and follicular lymphomas, as well as acute lymphoblastic leukemia (ALL) and multiple myeloma. The first two CAR T-cell therapies approved by the FDA, axicabtagene ciloleucel (axi-cel) a
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19

Neumann, Jacob, Yen Ting Lin, Abhishek Mallela, et al. "Implementation of a practical Markov chain Monte Carlo sampling algorithm in PyBioNetFit." Bioinformatics 38, no. 6 (2022): 1770–72. http://dx.doi.org/10.1093/bioinformatics/btac004.

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Abstract Summary Bayesian inference in biological modeling commonly relies on Markov chain Monte Carlo (MCMC) sampling of a multidimensional and non-Gaussian posterior distribution that is not analytically tractable. Here, we present the implementation of a practical MCMC method in the open-source software package PyBioNetFit (PyBNF), which is designed to support parameterization of mathematical models for biological systems. The new MCMC method, am, incorporates an adaptive move proposal distribution. For warm starts, sampling can be initiated at a specified location in parameter space and wi
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Murakami, Mark A., Alexandra N. Christodoulou, Amanda L. Christie, et al. "Proxe: A Public Repository of Xenografts to Facilitate Studies of Biology and Expedite Preclinical Drug Development in Leukemia and Lymphoma." Blood 126, no. 23 (2015): 3252. http://dx.doi.org/10.1182/blood.v126.23.3252.3252.

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Abstract To expedite the translation of biologic discoveries into novel therapeutics, there is a pressing need for panels of in vivo models that capture the molecular complexity of human disease. While traditional cell lines and genetically engineered mouse models are useful tools, they are insufficient to assess the broad diversity of human tumors within a context that recapitulates in situ biology. Patient-derived xenografts (PDXs), generated by transplanting primary human tumor cells into immune-deficient NOD.Cg-Prkdcscid/Il2rgtm1Wjl/SzJ (NSG) mice, surmount some of the limitations of these
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Yang, Yang, Timothy M. Walker, A. Sarah Walker, et al. "DeepAMR for predicting co-occurrent resistance of Mycobacterium tuberculosis." Bioinformatics 35, no. 18 (2019): 3240–49. http://dx.doi.org/10.1093/bioinformatics/btz067.

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Abstract Motivation Resistance co-occurrence within first-line anti-tuberculosis (TB) drugs is a common phenomenon. Existing methods based on genetic data analysis of Mycobacterium tuberculosis (MTB) have been able to predict resistance of MTB to individual drugs, but have not considered the resistance co-occurrence and cannot capture latent structure of genomic data that corresponds to lineages. Results We used a large cohort of TB patients from 16 countries across six continents where whole-genome sequences for each isolate and associated phenotype to anti-TB drugs were obtained using drug s
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Malangone, Elisabetta, Kathleen A. Foley, Kathleen Wilson, et al. "Treatment sequencing patterns of novel agents in patients with prostate cancer." Journal of Clinical Oncology 32, no. 30_suppl (2014): 296. http://dx.doi.org/10.1200/jco.2014.32.30_suppl.296.

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296 Background: The National Comprehensive Cancer Network (NCCN) guidelines recommend chemotherapy, immunotherapy or anti-androgen therapies for the treatment of advanced castration-resistant prostate cancer (CRPC). This study evaluated treatment sequencing of recently approved agents for CRPC [abiraterone (ABI), enzalutamide (ENZ), docetaxel (DOC), cabazitaxel (CAB), or sipuleucel-T (SIP)] among men with PC. Methods: This retrospective, observational study evaluated adult men with PC in the MarketScan Oncology EMR database, which includes data from over 900 contributing oncologists from over
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Simončič, M., D. Semenov, S. Krasnokutski, Th Henning, and C. Jäger. "Sensitivity of gas-grain chemical models to surface reaction barriers." Astronomy & Astrophysics 637 (May 2020): A72. http://dx.doi.org/10.1051/0004-6361/202037648.

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Context. The feasibility of contemporary gas-grain astrochemical models depends on the availability of accurate kinetics data, in particular, for surface processes. Aims. We study the sensitivity of gas-grain chemical models to the energy barrier Ea of the important surface reaction between some of the most abundant species: C and H2 (surface C + surface H2 → surface CH2). Methods. We used the gas-grain code ALCHEMIC to model the time-dependent chemical evolution over a 2D grid of densities (nH ∈ 103, 1012 cm−3) and temperatures (T ∈ 10, 300 K), assuming UV-dark (AV = 20 mag) and partly UV-irr
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Abdullah Hamid Salem and Ghadeer Razak Ahmed. "Study of the allelic frequency of HSPA6 gene and its genotypes and their effect on some characteristics of milk production in Holstein cows." University of Thi-Qar Journal of agricultural research 11, no. 2 (2022): 112–21. http://dx.doi.org/10.54174/utjagr.v11i2.189.

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The study was conducted at the Taj Al-Nahrain cattle station in Al-Diwaniyah Governorate, which is 200 km from the center of Dhi Qar Governorate. For the period from 10/15/2021 to 10/3/2022, 49 Holstein cows imported from Germany were used in this experiment, all in the third production cycle. And the laboratory part of the study was conducted in the laboratory of the Marsh Research Center \ Dhi Qar University for the purpose of separating the genetic material from cow blood samples and conducting genetic analysis on it and extracting the possible genotypes HSPA6 heat shock protein gene. The a
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Zakharyan, Aleksey A. "ON A PROSECUTOR AS A SUBJECT OF PROVING ON PRE-TRIAL STAGES OF A NATIONAL CRIMINAL PROCEDURE." Russian investigator 12 (December 17, 2020): 27–30. http://dx.doi.org/10.18572/1812-3783-2020-12-27-30.

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The participation of the prosecutor in the criminal process covers both his judicial and pre-trial stages. It is well known that the prosecutor in the Russian criminal process acts as the subject of evidence, not only as the state prosecutor, but mainly as the person conducting the criminal process or observing (supervising) his proceedings in the pre-trial stages of criminal proceedings. In the doctrine of the Russian criminal process, starting with the Charter of the Criminal Procedure of 1864 and up to and including the modern Code of Criminal Procedure of 2001, the prosecutor, to one degre
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Haymaker, Kathryn, Beth Malmskog, and Gretchen L. Matthews. "Locally recoverable codes with availability t≥2 from fiber products of curves." Advances in Mathematics of Communications 12, no. 2 (2018): 317–36. http://dx.doi.org/10.3934/amc.2018020.

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Wang, Gang, Min-Yao Niu, and Fang-Wei Fu. "Constructions of (r,t)-LRC Based on Totally Isotropic Subspaces in Symplectic Space Over Finite Fields." International Journal of Foundations of Computer Science 31, no. 03 (2020): 327–39. http://dx.doi.org/10.1142/s0129054120500112.

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Linear code with locality [Formula: see text] and availability [Formula: see text] is that the value at each coordinate [Formula: see text] can be recovered from [Formula: see text] disjoint repairable sets each containing at most [Formula: see text] other coordinates. This property is particularly useful for codes in distributed storage systems because it permits local repair of failed nodes and parallel access of hot data. In this paper, two constructions of [Formula: see text]-locally repairable linear codes based on totally isotropic subspaces in symplectic space [Formula: see text] over f
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Schultz, Corinna L., Suzanne M. McCahan, H. Timothy Bunnell, Fang Fang Chen, and Melissa A. Alderfer. "On-Line Patient Portal Use By Caregivers in Pediatric Oncology: Are We Widening Sociodemographic Disparities?" Blood 134, Supplement_1 (2019): 2131. http://dx.doi.org/10.1182/blood-2019-131543.

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BACKGROUND: Financial and regulatory incentives stemming from the Health Information Technology for Economic and Clinic Health Act have encouraged and, hence, increased the availability of online patient portals ('portals') that connect to electronic health records. Through portals, caregivers have direct access to portions of their child's medical record. Direct access is intended to engage caregivers in treatment and, consequently, to improve disease management. However, demonstrated associations between portal use and engagement in care is limited within pediatrics and non-existent in pedia
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Zou, Xianghui, Daniel King, Baho Sidiqi, Sunita Patruni, Christopher Hollweg, and Noah D. Kauff. "Socioeconomic disparities causing delays in pancreatic cancer germline genetic testing." Journal of Clinical Oncology 41, no. 4_suppl (2023): 665. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.665.

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665 Background: Germline genetic testing is recommended for patients with pancreatic ductal adenocarcinoma (PDAC) and pre-diagnostic testing is offered to patients with a significant family history. However, only 36% of patients in our institution obtained genetic testing. We identified associations between patient social profiles (income, race, ethnicity, social work needs) and delays in obtaining germline genetic testing from New York’s largest healthcare system. Methods: Patients with PDAC were identified using billing records across our institution with an IRB-approved protocol. Median inc
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Timoshenko, Igor. "Developing automatic identification technologies at RNPLS&T: From the past into the future." Scientific and Technical Libraries, no. 12 (December 27, 2018): 64–72. http://dx.doi.org/10.33186/1027-3689-2018-12-64-72.

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The author examines the problems of automatic identification and publicizes RNPLS&T’s designing equipment and technologies of bar-coding and radiofrequency identification for libraries. He discusses the possibility for developing library automation systems through implementing radiofrequency identification and developing the concepts of Electronic Product Code and Internet of Things. The author argues that this would significantly increase integration of traditional library collections and digital documents into the modern information environment. He also discusses the possibility for usin
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Coleman, Craig I., Kimberly Snow Caroti, Khaled Abdelgawwad, et al. "Patient Characteristics and Temporal Changes in Anticoagulation Treatment Patterns in Patients Diagnosed with Cancer-Associated Thrombosis: An Oscar-US Analysis." Blood 138, Supplement 1 (2021): 2132. http://dx.doi.org/10.1182/blood-2021-151566.

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Abstract Background: Although guidelines include direct-acting oral anticoagulants (DOACs) as an alternative to low molecular weight heparins (LMWHs) for treatment of cancer associated venous thrombosis (CAT), specific recommendations for selection of patients for DOAC treatment vary. Recommendations for use of DOACs are driven predominantly by perceptions of risk: benefit ratio (often associated with different cancer subtypes). We sought to assess patient characteristics and temporal changes in DOAC (vs. LMWH) utilization in patients being treated in routine practice for CAT. Methods: This an
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Smith, Matthew Lee, T. S. Sunil, Camerino I. Salazar, Sadaf Rafique, and Marcia G. Ory. "Disparities of Food Availability and Affordability within Convenience Stores in Bexar County, Texas." Journal of Environmental and Public Health 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/782756.

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The American Diabetes Association (ADA) recommends healthful food choices; however, some geographic areas are limited in the types of foods they offer. Little is known about the role of convenience stores as viable channels to provide healthier foods in our “grab and go” society. The purposes of this study were to (1) identify foods offered within convenience stores located in two Bexar County, Texas, ZIP Codes and (2) compare the availability and cost of ADA-recommended foods including beverages, produce, grains, and oils/fats. Data were analyzed from 28 convenience store audits performed in
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Mukherjee, Sudipto, Weichuan Dong, Aaron T. Gerds, et al. "Abstract A062: Age-, sex-, and race-related disparities in receipt of HypomethyLating Agents (HMA) for the treatment of myelodysplastic syndrome (MDS)." Cancer Epidemiology, Biomarkers & Prevention 32, no. 1_Supplement (2023): A062. http://dx.doi.org/10.1158/1538-7755.disp22-a062.

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Abstract Objective: Recent data suggest low use of HMAs in patients with MDS in real world. We sought to identify factors associated with HMA use. Methods: Using 2011-2014 Medicare data, we identified individuals ³65 years of age diagnosed with incident MDS during the years 2012-2013 and receiving their care exclusively through the Medicare fee-for-service system. Collected data included age, race, sex, morbidity burden based on their frailty status (robust, pre-frail, mildly frail, moderately, or severely frail), nursing home residence, presence of MDS-related clinical characteristics [cytope
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Schnittger, Susanne, Claudia Haferlach, Tamara Alpermann, Wolfgang Kern, and Torsten Haferlach. "IDH Mutations Can Be Detected In 28.7% of All Normal Karyotype AML and Have Unfavourable Impact on the NPM1+/FLT3-ITD- Genotype." Blood 116, no. 21 (2010): 102. http://dx.doi.org/10.1182/blood.v116.21.102.102.

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Abstract Abstract 102 Introduction: Mutations in IDH1 and IHD2 have recently been shown to play an important role in AML. As they code for enzymes from the citric acid cycle mutations within these genes from the mechanistical point of view are a totally new kind of mutation associated with AML. In IDH1 one mutational hot spot (amino acid R132) and in IDH2 two hotspots (R140 and R172) have been reported. We aimed at further delineating the impact of IDH1 and IDH2 mutations in AML and analyzed the interaction with other mutations in normal karyotype (NK) AML. Methods: 526 AML patients were selec
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du Plessis, Martin Johannes, Joubert van Eeden, and Leila Louise Goedhals-Gerber. "The Carbon Footprint of Fruit Storage: A Case Study of the Energy and Emission Intensity of Cold Stores." Sustainability 14, no. 13 (2022): 7530. http://dx.doi.org/10.3390/su14137530.

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Despite their importance in all transportation chains, logistical sites—and in particular refrigerated facilities—are the weakest link in current emissions literature. This is largely due to a lack of quantitative research that focuses on these facilities. This article is the first of its kind to assess the emissions of eight refrigerated facilities that handle and store fresh fruit. In 2020, the analyzed facilities moved a total of 646,572 pallets of fresh fruit and emitted 32,225 t of CO2e. Five of the largest facilities were responsible for handling 18.83% of the total fresh fruit exported
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Acquisgrana, María Del Rosario, Laura Cecilia Gómez Pamies, and Elisa Inés Benítez. "Hydrothermal Treatment to Remove Tannins in Wholegrains Sorghum, Milled Grains and Flour." Food Science and Nutrition Studies 3, no. 4 (2019): p122. http://dx.doi.org/10.22158/fsns.v3n4p122.

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Pigmented sorghum with high content of tannins were studied in this work. Tannins bind to proteins and reduce their availability. A hydrothermal treatment was carried out to reduce tannins. A control sample of non-pigmented pericarp variety was used. After the treatment, grains were milled, and a part was separated for wholegrain flour elaboration. Several determinations were done after treatment: tannins (T), total antioxidant capacity (TAC) and total polyphenols (TPP) content. TPP and TAC in wholegrain pigmented sorghum were 3.9 to 12.3 and 2.3 to 3.5 times higher than those of non-pigmented
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Sevindik, Tuğba Ongun, Hatice Tunca, Halim Aytekin Ergül, et al. "Lake morphometry underlies physical and chemical parameters affecting the distribution of phytoplankton functional groups in lakes of the Sakarya River Basin (Turkey)." Fundamental and Applied Limnology / Archiv für Hydrobiologie 194, no. 2 (2020): 125–40. http://dx.doi.org/10.1127/fal/2020/1338.

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To test the effects of lake morphometry (lake size and depth) on water quality parameters which affect the phytoplankton functional groups (FG) distribution, phytoplankton and some environmental parameters were sampled in November 2017 and May 2018 at the two or three monitoring stations in nine Lakes of Sakarya River Basin (Turkey). Lake size and depth affected phytoplankton FG distribution in both large-sized and small-sized lakes by affecting light availability which was mainly driven by the mixing events during the studied period. Al- though PO4 -P and alkalinity were the other main enviro
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Zhang, Lulu, Xiao Liu, Xiaoxiang Chen, et al. "SCANCell reveals diverse inter-cluster interaction patterns in systemic lupus erythematosus across the disease spectrum." Bioinformatics 38, no. 5 (2021): 1361–68. http://dx.doi.org/10.1093/bioinformatics/btab713.

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Abstract Motivation High-dimensional mass cytometry (CyTOF), which provides both cellular signatures and inter-cluster interactions like the antagonism between immune activation and suppression, and the pro-inflammatory synergy, sheds light on the cellular and molecular basis of disease pathogenesis. However, revealing the aberrance of inter-cluster communication networks in CyTOF datasets remains a significant challenge. Results Here, we developed Sample Classification and direct Association Network among Cell clusters (SCANCell) that quantifies the direct association (DA) network of cell clu
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Yani Mulyani, Patonah Hasimun, and Hajar Sukmawati. "Effect of nori, a combination of turmeric (Curcuma longa) and gotu kola (Centella Asiatica) on blood pressure, modulation of ACE, eNOS and iNOS gene expression in hypertensive rats." International Journal of Research in Pharmaceutical Sciences 12, no. 4 (2021): 2573–81. http://dx.doi.org/10.26452/ijrps.v12i4.4908.

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Hypertension is a major risk factor for causing life-threatening cardiovascular diseases such as myocardial infarction, coronary heart failure, kidney failure, and stroke. Its cases continue to increase worldwide and it is estimated that 1.56 billion adults would live with the condition in 2025. Therefore, this study aims to examine the antihypertensive effect of nori supplement prepared with a combination of turmeric (Curcuma longa) and gotu kola (Centella Asiatica) on L-NAME-induced and non-induced rats. It was conducted for 28 days on 25 wistar rats that were randomly assigned to the negati
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40

Stepanov, Vladimir S. "Assessing SARS-CoV-2-related mortality rate in Russian regions, based on the econometric model." Russian Journal of Infection and Immunity 12, no. 4 (2022): 783–89. http://dx.doi.org/10.15789/2220-7619-asr-1846.

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The objects of the study were the daily data on the population morbidity and mortality due to coronavirus disease 2019 (COVID-19) in Russian regions, as well as regional medical, demographic and environmental data recorded in recent years. COVID-19 is a contagious disease caused by the novel coronavirus (SARS-CoV-2). The mathematical methods consist of correlation and regression analysis, methods of testing statistical hypotheses. First, a multiple Variable Structure Regression should be specified. The intercept in the model differs from region to region, depending on the combination of values
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Yoo, Woo Sik, Kitaek Kang, Jung Gon Kim, and Yeongsik Yoo. "Image-Based Quantification of Color and Its Machine Vision and Offline Applications." Technologies 11, no. 2 (2023): 49. http://dx.doi.org/10.3390/technologies11020049.

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Image-based colorimetry has been gaining relevance due to the wide availability of smart phones with image sensors and increasing computational power. The low cost and portable designs with user-friendly interfaces, and their compatibility with data acquisition and processing, are very attractive for interdisciplinary applications from art, the fashion industry, food science, medical science, oriental medicine, agriculture, geology, chemistry, biology, material science, environmental engineering, and many other applications. This work describes the image-based quantification of color and its m
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42

Wallace, Erik A., Julie E. Miller-Cribbs, and F. Daniel Duffy. "An Experiential Community Orientation to Improve Knowledge and Assess Resident Attitudes Toward Poor Patients." Journal of Graduate Medical Education 5, no. 1 (2013): 119–24. http://dx.doi.org/10.4300/jgme-d-12-00015.1.

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Abstract Background Future physicians may not be prepared for the challenges of caring for the growing population of poor patients in this country. Given the potential for a socioeconomic “gulf” between physicians and patients and the lack of curricula that address the specific needs of poor patients, resident knowledge about caring for this underserved population is low. Intervention We created a 2-day Resident Academy orientation, before the start of residency training, to improve community knowledge and address resident attitudes toward poor patients through team-based experiential activiti
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Liu, Tongxin, Guobin Yang, Zhengyu Zhao, et al. "Design of Multifunctional Mesosphere-Ionosphere Sounding System and Preliminary Results." Sensors 20, no. 9 (2020): 2664. http://dx.doi.org/10.3390/s20092664.

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This paper describes a novel sounding system for which the functions of the medium frequency (MF) radar and the ionosonde are integrated on the same hardware platform and antenna structure, namely the middle atmosphere-ionosphere (MAI) system. Unlike the common MF radar, MAI system adopts the pseudo-random (PRN) phase-coded modulation technology, which breaks the limitation of the traditional monopulse mode. Through the pulse compression, only a small peak power is needed to achieve the signal-to-noise ratio (SNR) requirement. The excellent anti-jamming performance is also very suitable for th
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44

AlTaiar, Abdul Rahman Saad. "Factors affecting on the use of E-Commerce from the Perspective of Saudi Consumers." مجلة العلوم التربوية و الدراسات الإنسانية 4, no. 9 (2020): 361–85. http://dx.doi.org/10.55074/hesj.v4i9.121.

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The study aimed to identify the factors affecting the practice of e-commerce from the perspective of Saudi consumer, and the impact (technical infrastructure, and environmental legislation, culture, and skills of human resources) on the use of e-commerce.The study adopted the descriptive survey methodology in order to describe these factors. The target population of t this research is Al-Baha Region at kingdom of Saudi Arabia. The researcher designed and distributed 320 questionnaire forms and excluded 70 forms due to the lack of information which means overall sample is 250. The data for the
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45

Forte, Alaya. "Pious Practice and Secular Constraints." American Journal of Islam and Society 33, no. 2 (2016): 118–21. http://dx.doi.org/10.35632/ajis.v33i2.910.

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A research study grounded in both anthropology and ethnography, the aim ofJeanette S. Jouili’s Pious Practice and Secular Constraints: Women in the IslamicRevival in Europe is threefold: (1) to explore how women cultivate Islamicsubjectivities in secular European contexts that stigmatize and politicizesuch religious practices; (2) reveal the practical and discursive techniques theyhave devised to deal with the difficulties that emerge from engaging in piouspractices; and, finally, (3) attempts to show how living as a religious minorityin a secular-majority society can reshape traditional Islam
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Neil Sharma, Aakriti Bhatnagar, S. Vasudev, and Anamika Kohli. "A Cross-Sectional Study to Assess Awareness and Practices Related to Prevention of COVID-19 Amongst Local Vendors around Medical and Dental Establishments." International Healthcare Research Journal 5, no. 9 (2021): OR1—OR4. http://dx.doi.org/10.26440/ihrj/0509.12447.

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INTRODUCTION: Even as the world is returning to normalcy after COVID-19, there is still a need to be cautious and adopt proper hygiene practices and social distance norms. AIM: To assess the awareness and practices related to prevention of Covid-19 amongst local vendors around medical and dental establishments in Northern India. MATERIALS AND METHOD: This cross-sectional study was conducted over a period of one month using a pre-tested and pre-validated questionnaire. Vendors near ten medical and dental establishments in north India were contacted by standardized volunteers to prevent bias. Th
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Bibi, Shabana, Dong Wang, Yuanbing Wang, Ghazala Mustafa, and Hong Yu. "Mitogenomic and Phylogenetic Analysis of the Entomopathogenic Fungus Ophiocordyceps lanpingensis and Comparative Analysis with Other Ophiocordyceps Species." Genes 14, no. 3 (2023): 710. http://dx.doi.org/10.3390/genes14030710.

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Ophiocordyceps lanpingensis (O. lanpingensis) belongs to the genus Ophiocordyceps, which is often found in Yunnan Province, China. This species is pharmacologically important for the treatment of renal disorders induced by oxidative stress and an inadequate immune response. In the present study, the mitogenome of O. lanpingensis was determined to be a circular molecule 117,560 bp in length, and to have 31% G + C content and 69% A + T content. This mitogenome comprised 82% of the whole genome that codes for significant genes. The protein-coding regions of the O. lanpingensis mitogenome, contain
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Aung, Fleur M., Roland Bassett, Benjamin Lichtiger, and Emil J. Freireich. "Comparison of Two Apheresis Instruments (Old vs. New) for Granulocyte Collection: A Single Institutional Experience." Blood 128, no. 22 (2016): 5036. http://dx.doi.org/10.1182/blood.v128.22.5036.5036.

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Abstract Background: A retrospective analysis was performed to evaluate the collection efficiency of two apheresis devices for granulocytes using the Spectra Optia (TerumoBCT) vs. the Cobe Spectra (Cobe: TerumoBCT) which served as control. Study Design and Methods: A total of 410 granulocyte collections (GCs) were collected from volunteer healthy blood donors (<4%) and family and friends of severely neutropenic oncology patients requiring GCs from July 2014 to November 2015. All healthy male and females donors eligible to donate blood with peripheral venous access were allowed to donate gra
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Gálvez, David Morillón, Iván García Kerdan, and Germán Carmona-Paredes. "Assessing the Potential of Implementing a Solar-Based Distributed Energy System for a University Using the Campus Bus Stops." Energies 15, no. 10 (2022): 3660. http://dx.doi.org/10.3390/en15103660.

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Large educational facilities hold great potential for the implementation of solar-based distributed energy systems. The aim of this paper is to present a prototype and an assessment of a solar-based bus shelter photovoltaic system intended to be implemented at a campus scale that serves as an energy-distributed system. The National Autonomous University of Mexico (UNAM), a campus with an area of 7.3 km2 and bus stops’ roof area availability of around 1100 m2 was selected as a case study. The proposed system, apart from considering on-site generation, also considers an increase in end-use servi
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Gershwin, M. E., I. R. Mackay, A. Sturgess, and R. L. Coppel. "Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis." Journal of Immunology 138, no. 10 (1987): 3525–31. http://dx.doi.org/10.4049/jimmunol.138.10.3525.

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Abstract Mitochondrial autoantibodies are characteristic of the disease primary biliary cirrhosis (PBC), but the immunoreactive mitochondrial antigens have not been defined. We used a rat liver cDNA library in lambda gt 11-Amp3 to clone a 1370-base pair insert that coded for a polypeptide reactive with PBC sera. This insert was subcloned for expression into pBTA224, a plasmid vector in the same reading frame as lambda-Amp3. A positive clone, designated pRMIT, that expressed a fused polypeptide of 160 kd, was recognized by 25 of 25 sera from patients with PBC and none of 96 sera from normal per
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