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Alotaibi, Fayez Salem Marzoq, Wafa Jazi Alhamereen, Saosan Abdulrahman Almogisib, Ohoud Jazi Alhamereen, Tahani Mohammed Alanazi, Safa Diab Alokaili, Awad Lafi Almutairi, Sultan M. Abuqayyan i Yahya Mohammed alzain. "Assessment of Depression and Smoking in Chronic Obstructive Pulmonary Disease Patients". International Journal Of Pharmaceutical And Bio-Medical Science 02, nr 11 (30.11.2022): 557–60. http://dx.doi.org/10.47191/ijpbms/v2-i11-15.
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Background: Depression is common in COPD patients, and smokers are more likely to develop it. Methods: The smoking habits of 100 people with COPD were evaluated for the study during either an outpatient visit or a hospital stay. The Hamilton depression rating scale was used to assess depression in the study population (HAM-D). Result: The majority of the COPD patients in the current study were former smokers. The findings indicated that former smokers were more likely to experience depressed symptoms. Conclusion: Depression is a common condition among COPD patients. The findings revealed that patient age and smoking habits had a significant impact on the progression of COPD illness.
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Uryasev, O. M., S. V. Faletrova i L. V. Korshunova. "Combination of asthma and chronic obstructive pulmonary disease: features of etiology, pathogenesis, diagnosis, pharmacotherapy". Kazan medical journal 97, nr 3 (15.06.2016): 394–400. http://dx.doi.org/10.17750/kmj2016-394.
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Bronchial asthma and chronic obstructive pulmonary disease are the most common obstructive diseases of the respiratory system. 230 million people suffer from chronic obstructive pulmonary disease, from bronchial asthma - 300 million people worldwide. Annually 200-300 people in Europe and 2.74 million of world population die from chronic obstructive pulmonary disease, from asthma - 250 thousand people a year. The social and economic significance of these diseases determine the need for in-depth study of their combination in the same patient. Each disease has its own phenotypes, but in 10-20% of patients, there are symptoms of both chronic obstructive pulmonary disease and asthma. In spite of clear diagnostic criteria, in some cases it is difficult to distinguish these diseases. Morphological basis of these diseases is a chronic inflammation in the bronchial tree that causes damage to the epithelial continuity that initiates bronchoconstrictive reaction and leads to irreversible airway obstruction attributable for both severe bronchial obstruction and chronic obstructive pulmonary disease. However, the treatment strategy of bronchial asthma and chronic obstructive pulmonary disease has significant differences, it is important to have a clear diagnostic criteria to distinguish different phenotypes, including those of combined phenotype of asthma and chronic obstructive pulmonary disease. Rational starting therapy of asthma and chronic obstructive pulmonary disease overlap syndrome includes drugs acting on the pathogenic mechanisms of both diseases, and is a combination of inhaled corticosteroids with combined bronchodilator therapy - long-acting β2-agonists and long-acting anticholinergics.
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Preveden, Andrej, Mirko Todic, Vanja Drljevic-Todic, Mihaela Preveden, Ranko Zdravkovic i Biljana Zvezdin. "Use of beta blockers in patients with asthma and chronic obstructive pulmonary disease". Medical review 74, nr 3-4 (2021): 127–33. http://dx.doi.org/10.2298/mpns2104129p.
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Introduction. Beta blockers play an essential role in the treatment of cardiovascular diseases, but also various other endocrinological, gastroenterological, ophthalmological and neurological disorders. The most important effects of beta blockers are a reduction in myocardial oxygen consumption and inhibition of renin secretion. Beta blockers are divided into three generations according to their selectivity - non-selective, cardioselective and vasodilating beta blockers. Beta blockers and obstructive pulmonary diseases. Patients with obstructive pulmonary diseases are significantly more likely to develop cardiovascular diseases compared to general population, largely due to common risk factors such as smoking, systemic inflammation, age, and genetic predisposition. The use of nonselective beta blockers carries a great risk for patients with obstructive pulmonary diseases, while cardioselective beta blockers can be used more extensively. Reversible airway obstruction is predominantly present in asthma, so that the adverse effects of beta blockers on the airways are significantly more pronounced in asthma compared to chronic obstructive pulmonary disease. Conclusion. In both asthma and chronic obstructive pulmonary disease, the use of highly cardioselective beta blockers such as bisoprolol and nebivolol is preferred. The use of beta blockers in patients with asthma requires great caution due to the possibility of bronchial obstruction, while in patients with chronic obstructive pulmonary disease they are somewhat safer. Patients must be closely monitored by a physician, with special attention focused on clinical signs of airway obstruction such as wheezing, shortness of breath, and prolonged expiration.
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Rasputina, Lesya, i Daria Didenko. "PREVALENCE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN PATIENTS WITH CORONARY HEART DISEASE AND ARTERIAL HYPERTENSION". EUREKA: Health Sciences 2 (31.03.2017): 38–45. http://dx.doi.org/10.21303/2504-5679.2017.00320.
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The prevalence of chronic obstructive pulmonary disease among patients with cardio-vascular diseases is higher than in general population. At the same time the one of problems of internal medicine is a timely diagnostics of chronic obstructive pulmonary disease. The aim of the work was the study of prevalence of chronic obstructive pulmonary disease among patients with cardio-vascular diseases, especially arterial hypertension and coronary heart disease. Materials and methods. The retrospective analysis of statistical cards of patients, who were on stationary treatment at therapeutic departments, was carried out to estimate the prevalence of combination of chronic obstructive pulmonary disease with arterial hypertension. The target examination of 136 patients was realized for revelation of chronic obstructive pulmonary disease. All patients were interrogated by the original modified questionnaire of assessment of short breath by medical research council (mMRC), test for assessment of chronic obstructive pulmonary disease (CAT) and underwent spirography with bronchodilatation test. Results. It was established, that 10,2 % of patients had the combination of chronic obstructive pulmonary disease with arterial hypertension. Among persons, who were on treatment as to the stable coronary heart disease and had not obstructive disease of respiratory organs in anamnesis, in 26,4 % the chronic obstructive pulmonary disease was diagnosed for the first time.
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Sijapati, Milesh Jung, Narayan Bikram Thapa, Rajendra Rijal, Shiva Raj KC i Poojyashree Karki. "Bronchiectasis in patients with chronic obstructive pulmonary disease". Journal of Pathology of Nepal 8, nr 2 (6.09.2018): 1346–49. http://dx.doi.org/10.3126/jpn.v8i2.20870.
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Background: Chronic obstructive pulmonary disease is most common disease entity and third leading cause of mortality worldwide. The presence of bronchiectasis in severe chronic obstructive pulmonary disease patients had led to frequent exacerbation requiring hospitalizations. The purpose of this study was to identify the factors associated with bronchiectasis, using routine data collected during medical visits from patients diagnosed with chronic obstructive pulmonary disease.Materials and Methods: This is hospital based cross sectional study conducted on 120 chronic obstructive pulmonary disease patients. All patients were subjected through history, examination, pulmonary function test, sputum samples and imaging of chest.Results: Out of 120 patients among them 67 patients (55.8%) were chronic obstructive pulmonary disease without bronchiectasis while 53 patients (44.1%) had chronic obstructive pulmonary disease with bronchiectasis. Thirty patients (56.6%) having chronic obstructive pulmonary disease with bronchiectasis and 18 patient (26.8%) having chronic obstructive pulmonary disease without bronchiectasis had exacerbation in one year requiring hospitalisation. Most common organisms isolated were Pseudomonas Aeruginosa in 20 patients (55.5%), Klebsillae Pneumoniae in 6 patients (16.6%) among chronic obstructive pulmonary disease with bronchiectasis group.Conclusion: Chronic obstructive pulmonary disease patient with severe airflow limitation, with frequent exacerbation and colonisation with isolation of organisms resulting in bronchiectasis requiring frequent hospitalisation.
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Shrestha, Ashis, i Sumana Bajrachraya. "Spirometry Findings in Patients with Chronic Obstructive Pulmonary Disease". Journal of Patan Academy of Health Sciences 1, nr 1 (20.07.2015): 33–35. http://dx.doi.org/10.3126/jpahs.v1i1.13014.
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Introductions: Clinical diagnosis of chronic obstructive pulmonary disease is often not accurate and treated for prolong duration. This study explores the use of pulmonary function test to confirm the diagnosis and further management of such patients. Methods: This was a cross sectional study conducted at Patan Hospital, Patan Academy of Health Sciences, Nepal. All patients coming for spirometry between June 2012 and May 2013 with the clinical diagnosis of chronic obstructive pulmonary disease were enrolled in the study. Results: Out of 338 patients with clinical diagnosis of chronic obstructive pulmonary disease that underwent spirometry, 80 (23.7%) patients had ratio of forced expiratory volume in one second and forced vital capacity less than 70%. Out of these 80 patients, 50 (14.8%) had irreversible airway obstruction and 30 (8.9%) had reversible airway obstruction. Patient with normal spirometry findings was 258(76.3%). Conclusions: Clinically diagnosed chronic obstructive pulmonary disease is best confirmed by spirometry for optimum management. Plain Language Summary: The study was done to see whether the clinical diagnosis of COPD is accurate of not. The study found that most of the patient diagnosed as COPD did not have the disease on spirometry. So, diagnosis of COPD should always be aided by spirometry before starting long term treatment. DOI: http://dx.doi.org/10.3126/jpahs.v1i1.13014 Journal of Patan Academy of Health Sciences. 2014 Jun;1(1):33-35
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Helena, González. "Body Composition, Functional Status and Clinical Outcomes in Patients with Chronic Obstructive Pulmonary Disease". Biomedical Research and Clinical Reviews 2, nr 1 (24.12.2020): 01–06. http://dx.doi.org/10.31579/2692-9406/025.
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Objective: To define the correlation between the Fat Free Mass Index (FFMI), the muscle function, degree of airflow obstruction, the respiratory symptoms and the number of exacerbations during the last year in patients with Chronic Obstructive Pulmonary Disease (COPD). Methods: Prospective and cross-sectional study of subjects older than 40 years with a clinical diagnosis of COPD who underwent measurement of the FFMI and muscular function to determine if these were correlated with the variables of severe COPD. Results: 55 patients Participated in the study. The FFMI was below 32.7% (n=18) and the strength diminished in 56.4% (n=31). In the sample, we found a direct and significant correlation between the FFMI and the FEV1* (predicted %), (p= 0,045). When analyzed by sex, men had a direct correlation between FFMI and the FEV1*(predicted %), (p=0,019), an inverse correlation between FFMI and the spirometric classification of the Global Initiative Obstructive Lung Disease (GOLD) (p=0,008) and between the muscular function and the symptoms (p=0, 03). In women no significant correlation was found. Conclusions: The conditions in mass and the muscular function were correlated with clinical variables and pulmonary function in men, but not in women. We did not find a correlation between corporal composition and the number of exacerbations.
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Lazovic, Biljana, Mirjana Zlatkovic-Svenda, Sanja Mazic, Zoran Stajic i Marina Djelic. "Analysis of electrocardiogram in chronic obstructive pulmonary disease patients". Medical review 66, nr 3-4 (2013): 126–29. http://dx.doi.org/10.2298/mpns1304126l.
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Introduction. Chronic obstructive pulmonary disease is the fourth leading cause of mortality worldwide. It is defined as a persistent airflow limitation usually progressive and not fully reversible to treatment. The diagnosis of chronic obstructive pulmonary disease and severity of disease is confirmed by spirometry. Chronic obstructive pulmonary disease produces electrical changes in the heart which shows characteristic electrocardiogram pattern. The aim of this study was to observe and evaluate diagnostic values of electrocardiogram changes in chronic obstructive pulmonary disease patients with no other comorbidity. Material and Methods. We analyzed 110 electrocardiogram findings in clinically stable chronic obstructive pulmonary disease patients and evaluated the forced expiratory volume in the first second, ratio of forces expiratory volume in the first second to the fixed vital capacity, chest radiographs and electrocardiogram changes such as p wave height, QRS axis and voltage, right bundle branch block, left bundle branch block, right ventricular hypertrophy, T wave inversion in leads V1-V3, S1S2S3 syndrome, transition zone in praecordial lead and QT interval. Results. We found electrocardiogram changes in 64% patients, while 36% had normal electrocardiogram. The most frequent electrocardiogram changes observed were transition zone (76.36%) low QRS (50%) and p pulmonale (14.54%). Left axis deviation was observed in 27.27% patients. Conclusion. Diagnostic values of electrocardiogram in patients with chronic obstructive pulmonary disease suggest that chronic obstructive pulmonary disease patients should be screened electrocardiographically in addition to other clinical investigations.
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Hayat, Atif Sitwat, Abdul Haque Khan, Ghulam Nabi Pathan i Mohammad Zubair Mushtaque. "CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)". Professional Medical Journal 23, nr 09 (10.09.2016): 1073–78. http://dx.doi.org/10.29309/tpmj/2016.23.09.1701.
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Objectives: Chronic obstructive pulmonary disease (COPD) leads to partialreversible obstruction of airways. The objective of our study is to determine frequency ofelevated C-reactive protein (CRP) level in patients of COPD at Liaquat University HospitalJamshoro/Hyderabad. Study Design: Cross-sectional study. Setting: Medical Unit-I of LiaquatUniversity Hospital Jamshoro/Hyderabad. Period: 1st March 2013 to 31st August 2013. Patientsand Methods: Patients of either sex and ages from 40-80 years old and having COPD for atleast two years duration were included. Patients below 40 years of age, having malignanciesor autoimmune disorders were excluded from this study. Results: We enrolled 186 patientswith COPD and their mean age was ± SD 57.63±8.45 years. Majority 182 (97.8%) had habitof smoking while 4(2.2%) were non-smokers. Mean CRP level in COPD patients was ± SD1.26±0.79 (range 0.1- 3.0 mg/d1). Out of 186 COPD patients, 94(50.6%) have raised CRP level(higher than 1.0 mg/dl). Median value of CRP level during this study was 1.10 mg/dl. About92(49.4%) patients have normal level of CRP (less than 1.0 mg/dl). Conclusion: On conclusion,frequency of raised C-reactive protein in our study was much higher (50.6%).
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Gupta, Nidhi, Gajendra Dubey, Citralekha Vora, Tarun Madan, Pankaj Garg i Usha Patel. "Cardiac Co-morbidities in Patients with Chronic Obstructive Pulmonary Disease: Prospective Observational Study". Journal of Cardiovascular Medicine and Surgery 4, nr 2 (2018): 108–13. http://dx.doi.org/10.21088/jcms.2454.7123.4218.6.
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Khan, Iqbal. "Stigma towards Patients with Chronic Obstructive Pulmonary Disease: To Help or To Judge?" Biomedical Research and Clinical Reviews 4, nr 3 (23.07.2021): 01–04. http://dx.doi.org/10.31579/2692-9406/063.
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Chronic Obstructive Pulmonary Disease (COPD), the third leading cause of mortality worldwide, is a highly incapacitating irrevocable health problem, with pulmonary and extra-pulmonary manifestations. According to Suzanne Hurd and Claude Lenfant, it is “the only chronic disease for which the finger of blame can be pointed to a single risk factor – tobacco smoking”. However, only 15-20% of smokers are afflicted. Whereas smoking is far from being the only cause, substantial proportion of COPD cases cannot be explained by smoking alone. The visibility of distressing and frightening physical manifestations of symptoms leads to serious ‘‘observable’’ consequences, such as disability or lack of control, public use of oxygen and rescue inhalers. As a result “they are disqualified from full social acceptance”. However, the stigma is not the only factor responsible for the miseries of those with COPD. In fact, there are many misconceptions in this scenario which have been discussed. The need of a huge awareness campaign for the public to improve their understanding of lung diseases (notably COPD) has been highlighted. The patient, healthcare professionals and the health services should be prepared to play their new role in the management of a chronic disease like COPD “requiring “ongoing management over a period of years or decades”. The importance of a self-management strategy has been emphasised.
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Mycroft, Katarzyna, i Katarzyna Górska. "Diagnosis and management of COPD in primary care". Medycyna Faktów 14, nr 4 (31.12.2021): 350–55. http://dx.doi.org/10.24292/01.mf.0421.3.
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Chronic obstructive pulmonary disease is a significant health problem. However, a large proportion of cases remain undiagnosed. Early diagnosis of chronic obstructive pulmonary disease leads to earlier treatment initiation, and in consequence, to improvement of patients quality of life. The gold standard for chronic obstructive pulmonary disease diagnosis is spirometry and the presence of irreversible obstruction after a bronchodilator. One of the most important interventions in the treatment of chronic obstructive pulmonary disease is anti-smoking education. The main group of drugs used in chronic obstructive pulmonary disease treatment are the long-acting bronchodilators.
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Rozenbaum, Wlodzimierz ‘Vlady’. "Patients with Chronic Obstructive Pulmonary Disease". Disease Management & Health Outcomes 16, nr 5 (2008): 353–58. http://dx.doi.org/10.2165/0115677-200816050-00012.
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Daga, Mradul Kumar. "Osteoporosis in Chronic Obstructive Pulmonary Disease: More than just a Comorbidity". Journal of Advanced Research in Medicine 07, nr 03 (22.12.2020): 7–21. http://dx.doi.org/10.24321/2349.7181.202011.
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Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of mortality and loss of Disability-Adjusted Life-Years (DALYs) worldwide. It often is accompanied by the presence of various systemic comorbidities including osteoporosis which may have an impact on the course of the disease. Osteopenia and osteoporosis are the consequences of loss of Bone Mineral Density (BMD) and have been widely known major comorbidities in COPD patients. Female sex, age, and smoking are common pathogenic factors for both COPD and osteoporosis, other factors such as reduced daily physical activity, malnutrition, low body mass index, hypogonadism, vitamin D deficiency, chronic renal insufficiency, chronic hypoxemia, and drugs like corticosteroids, have been invoked to explain such a frequent association between them. Osteoporosis in COPD is however often undertreated. It has been shown in recent studies that both decreased Bone Mineral Density (BMD) and impaired bone quality contribute to bone fragility, causing fractures in COPD patients. Pulmonary function and activities of the daily life of COPD patients may be further deteriorated by osteoporosis-associated fractures. Calcium and vitamin D, hormone replacement when indicated, calcitonin, and bisphosphonate administration are few effective strategies to tackle bone loss and osteoporosis. Awareness about this high prevalence of osteoporosis in COPD patients is critically important and physicians should look for such fracture risks. Routine screening and early diagnosis of osteoporosis will enable physicians to provide the appropriate treatment to prevent fracture, which leads to improved quality of life as well as better long-term prognosis.
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Ish, Pranav. "An Epidemiological Study on Risk Factors of Chronic Obstructive Pulmonary Disease". Epidemiology International 06, nr 01 (30.03.2021): 15–21. http://dx.doi.org/10.24321/2455.7048.202104.
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Introduction: Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of morbidity and mortality worldwide and is expected to increase in the coming decades due to increasing air pollution. In a country like India, it is a challenge to control the growing incidence of COPD. For this, it is imperative to understand the various risk factors that lead to the development of COPD including smoking and the ever-worsening environmental air pollution levels. Material and Methods: This prospective case-control study was carried out at the out-patient clinic of pulmonary medicine at our tertiary care centre. Clinical severity data, demographic characteristics, smoking history, and particulate matter (PM) 2.5 levels at the residence of the patients were recorded. A total of 182 cases of COPD and 365 controls were taken. Result: COPD was found to be common among males (69.2%), among the factory workers, drivers and roadside vendors and in elderly age groups. COPD was found to be associated with exposure to active and passive smoking (p < 0.05). Exposure to dust, fumes, and smoke at the workplace was significantly more prevalent among the COPD patients (13.2%) than the control group (2.7%). Besides, 61.5% of the COPD patients were residing in the area with PM 2.5 levels > 60μg/m3 which was significantly greater than the controls (44.9%). Conclusion: The main risk factor for COPD is exposure to active and passive tobacco smoking. Other environmental factors such as exposure to dust, fumes at the workplace and home are also associated with COPD. Level of PM 2.5 > 60 μg/m3 is associated with an increased risk of COPD. Thus, the environmental history of residence in Delhi or a city with high AQI is significant in evaluating a COPD patient. It is important to understand the contribution of these risk factors as curbing and curtailing them can help prevent and control the growing burden of COPD.
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Ish, Pranav. "An Epidemiological Study on Risk Factors of Chronic Obstructive Pulmonary Disease". Epidemiology International 06, nr 01 (30.03.2021): 15–21. http://dx.doi.org/10.24321/2455.7048.202104.
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Introduction: Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of morbidity and mortality worldwide and is expected to increase in the coming decades due to increasing air pollution. In a country like India, it is a challenge to control the growing incidence of COPD. For this, it is imperative to understand the various risk factors that lead to the development of COPD including smoking and the ever-worsening environmental air pollution levels. Material and Methods: This prospective case-control study was carried out at the out-patient clinic of pulmonary medicine at our tertiary care centre. Clinical severity data, demographic characteristics, smoking history, and particulate matter (PM) 2.5 levels at the residence of the patients were recorded. A total of 182 cases of COPD and 365 controls were taken. Result: COPD was found to be common among males (69.2%), among the factory workers, drivers and roadside vendors and in elderly age groups. COPD was found to be associated with exposure to active and passive smoking (p < 0.05). Exposure to dust, fumes, and smoke at the workplace was significantly more prevalent among the COPD patients (13.2%) than the control group (2.7%). Besides, 61.5% of the COPD patients were residing in the area with PM 2.5 levels > 60μg/m3 which was significantly greater than the controls (44.9%). Conclusion: The main risk factor for COPD is exposure to active and passive tobacco smoking. Other environmental factors such as exposure to dust, fumes at the workplace and home are also associated with COPD. Level of PM 2.5 > 60 μg/m3 is associated with an increased risk of COPD. Thus, the environmental history of residence in Delhi or a city with high AQI is significant in evaluating a COPD patient. It is important to understand the contribution of these risk factors as curbing and curtailing them can help prevent and control the growing burden of COPD.
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Weissler, Jonathan C., i Traci N. Adams. "Eosinophilic Chronic Obstructive Pulmonary Disease". Lung 199, nr 6 (5.11.2021): 589–95. http://dx.doi.org/10.1007/s00408-021-00492-0.
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AbstractRecent therapeutic advances in the management of asthma have underscored the importance of eosinophilia and the role of pro-eosinophilic mediators such as IL-5 in asthma. Given that a subset of patients with COPD may display peripheral eosinophilia similar to what is observed in asthma, a number of recent studies have implied that eosinophilic COPD is a distinct entity. This review will seek to contrast the mechanisms of eosinophilia in asthma and COPD, the implications of eosinophilia for disease outcome, and review current data regarding the utility of peripheral blood eosinophilia in the management of COPD patients.
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Cekerevac, Ivan, i Zorica Lazic. "Obesity and chronic obstructive pulmonary disease". Srpski arhiv za celokupno lekarstvo 139, nr 5-6 (2011): 322–27. http://dx.doi.org/10.2298/sarh1106322c.
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Introduction. Nutritional abnormalities have one of the most important systematic effects on chronic obstructive pulmonary disease (COPD). A relationship between COPD and obesity has been observed and recognized. In COPD patients, beside changes in the total body weight, changes in body composition are also possible with the loss of fat-free mass (FFM). Objective. This study was undertaken to evaluate the impact of obesity and the change of body composition on the pulmonary function, dyspnoea level and the quality of life in COPD patients. Methods. Seventy-nine patients in the stable state of COPD were evaluated. Pulmonary function and arterial blood gas analysis were assessed. Nutritional status was analyzed according to Body Mass Index (BMI). Body composition was evaluated by using anthropometric measurement by fat free mass index (FFMI). Quality of life was assessed using the St. George Respiratory Questionnaire (SGRQ). The Visual Analogue Scale (VAS) was used to evaluate dyspnoea. Results. The highest prevalence of obesity (50.0%) was found in patients with mild COPD, while the lowest prevalence was detected in very severe COPD patients (10.0%). The loss of FFM occurred in 22.2% patients with normal body weight and in 9.0% of overweight COPD patients. The quality of life was lower in obese patients compared to other COPD patients. A higher dyspnoea level was also present in obese patients. The lowest airflow obstruction was in obese patients (p=0.023). We found a significant positive correlation between forced expiratory volume in the first second (FEV1%) and BMI (r=0.326, p=0.003), FEV1% and FFMI (r=0.321, p=0.004). Conclusion. The highest prevalence of obesity was in patients with mild COPD. Obese patients with COPD had the lowest level of airflow obstruction, higher dyspnoea level and lower quality of life in comparison to other COPD patients.
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Sukholytka, Mariia. "Hypothyroidism and chronic obstructive pulmonary disease". INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 16, nr 8 (6.04.2021): 643–47. http://dx.doi.org/10.22141/2224-0721.16.8.2020.222884.
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The risk of chronic obstructive pulmonary disease (COPD), as well as thyroid diseases increases with age. COPD is a common systemic disease associated with chronic inflammation. Many endocrinological disorders, including thyroid gland diseases are related to systemic inflammation. Epidemiological studies suggest that patients with COPD are at higher risk of thyroid disorders. These associations are not well-studied and thyroid gland diseases are not included on the broadly acknowledged list of COPD comorbidities. They may seriously handicap quality of life of COPD patients. Unfortunately, the diagnosis may be difficult, as many signs are masked by the symptoms of the index disease. The comprehension of the correlation between thyroid gland disorders and COPD may contribute to better care of patients. In this review, we attempt to revise available literature describing existing links between COPD and thyroid diseases. The signs or symptoms of thyroid disorders may be non-specific, especially among the elderly, therefore the differential diagnosis between symptoms of COPD and symptoms related to thyroid disease can cause difficulties. Many data show higher risk of thyroid hormones alterations in COPD patients. Hypothyroidism may influence respiration by different mechanisms, even in subjects with intact respiratory system. Therefore, it is hard to distinguish whether hormonal changes are the reason or a consequence of different respiratory signs and symptoms. In some instances, the correction of hormonal alternations may improve the quality of life of COPD patients and other disease outcomes. The comprehension of an association between COPD, thyroid gland function and thyroid disorders may provide important information about the systemic nature of COPD.
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Kulik, E. G., V. I. Pavlenko i S. V. Naryshkina. "СLINICAL EFFECTIVENESS OF COMPLEX LONG-TERM THERAPY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE". Amur Medical Journal, nr 15-16 (2016): 75–76. http://dx.doi.org/10.22448/amj.2016.15-16.75-76.
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Fattaeva, D. R., J. A. Rizaev, D. A. Raximova i A. A. Kholikov. "CLINICAL PICTURE OF SINUSITIS IN PATIENTS AFTER COVID-19 WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE". UZBEK MEDICAL JOURNAL 2, nr 2 (28.02.2021): 53–58. http://dx.doi.org/10.26739/2181-0664-2021-2-7.
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The significance of the combined pathology of the maxillary sinus and bronchi after coronavirus infection is determined not only by the prevalence and severity of the diseasebut also by the negative effect on the body as a whole andthe low effectiveness of the treatment. One of the main directions of therapeutic measuresisafter coronavirus infection is the correction of the imbalance of the hemostasis system detected in such patients (Orekhova L.Yu. et al., 2020; Shapavalov V.D., 2020). In the domestic and foreign literature, there are practically no scientifically substantiated data on the possibilities of an integrated approach to systemic methods of treating chronic sinusitis after suffering from covid-19 (CG -PC), combined with chronic obstructive pulmonary disease and bronchial asthma, which is due to the functional and industrial disunity of dentists with doctors’ other specialties
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Ji, Yafeng, Hongliang Gao, Yongli Wang i Xuesheng Jiang. "Diagnostic Significance of β-Collagen Degradation Products and Osteocalcin in Chronic Obstructive Pulmonary Disease Complicated with Osteoporosis". Current Topics in Nutraceutical Research 20, nr 2 (18.09.2021): 288–92. http://dx.doi.org/10.37290/ctnr2641-452x.20:288-292.
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Chronic obstructive pulmonary disease is a pulmonary dysfunction common to the middle-aged and elderly population. About 20–60% of patients with moderate or severe chronic obstructive pulmonary disease suffer from different degrees of osteoporosis. A strong relationship between β-collagen degradation products and osteocalcin has been shown in several bone diseases, but their roles in chronic obstructive pulmonary disease remain to be investigated. This study was designed to explore such a relationship in patients with chronic obstructive pulmonary disease complicated with osteoporosis. The β-collagen degradation products were the highest in the serum of patients diagnosed with both chronic obstructive pulmonary disease and osteoporosis followed by those with chronic obstructive pulmonary disease only and osteoporosis only. According to the receiver operating characteristic analysis curves, both β-collagen degradation products and osteocalcin had favorable predictive values for patients with chronic obstructive pulmonary disease, osteoporosis or both. In addition, β-collagen degradation products were negatively correlated with forced expiratory volume in 1 s and bone mineral density, while osteocalcin was positively correlated with them. β-collagen degradation products increase, and osteocalcin decreases in patients with both chronic obstructive pulmonary disease and osteoporosis.
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Muller, N. L. "Chronic obstructive pulmonary disease * 4: Imaging the lungs in patients with chronic obstructive pulmonary disease". Thorax 57, nr 11 (1.11.2002): 982–85. http://dx.doi.org/10.1136/thorax.57.11.982.
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Ruse, Charlotte E., i Andrew W. P. Molyneux. "Management and implications of chronic obstructive pulmonary disease (COPD) for older patients". Reviews in Clinical Gerontology 15, nr 2 (maj 2005): 91–104. http://dx.doi.org/10.1017/s095925980600178x.
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Airflow obstruction is common in older persons but frequently under-diagnosed. The term refers to a spectrum of chronic respiratory disorders characterized by cough, dyspnoea, mucus hypersecretion, wheeze and impaired pulmonary function tests. Patients may be diagnosed as having late-onset asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema or fixed airflow obstruction of the elderly.
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O'Kane, Lisa, i Michael Groher. "Oropharyngeal dysphagia in patients with chronic obstructive pulmonary disease: a systematic review". Revista CEFAC 11, nr 3 (21.08.2009): 449–506. http://dx.doi.org/10.1590/s1516-18462009005000040.
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BACKGROUND: oropharyngeal dysphagia in patients with chronic obstructive pulmonary disease. PURPOSE: patients with Chronic Obstructive Pulmonary Disease (COPD) can be vulnerable to respiratory incompetence that may lead to swallowing impairment. A systematic review was conducted to investigate the relationship between Chronic Obstructive Pulmonary Disease and oropharyngeal dysphagia. Forty-seven articles were retrieved relating to Chronic Obstructive Pulmonary Disease and dysphagia. Each article was graded using evidence-based methodology. Only 7 articles out of the 47 addressed oropharyngeal swallowing disorders in patients with Chronic Obstructive Pulmonary Disease. This review found few studies that documented the relationship between oropharyngeal swallowing disorders and Chronic Obstructive Pulmonary Disease. There were no randomized control trials. CONCLUSION: although the evidence is not strong, it appears that patients with Chronic Obstructive Pulmonary Disease are prone to oropharyngeal dysphagia during exacerbations. Future studies are needed to document the prevalence of oropharyngeal dysphagia in homogeneous groups of patients with Chronic Obstructive Pulmonary Disease, and to assess the relationship between respiration and swallowing using simultaneous measures of swallowing biomechanics and respiratory function. These investigations will lead to a better understanding of the characteristics and risk factors of developing oropharyngeal dypshagia in patients with Chronic Obstructive Pulmonary Disease.
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Re, Roberta. "Thromboembolic disease and chronic obstructive pulmonary disease". Clinical Management Issues 4, nr 3S (13.10.2015): 55–61. http://dx.doi.org/10.7175/cmi.v4i3s.1155.
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Venous thromboembolism is still a leading cause of mortality and morbidity for hospitalised patients. While the awareness of the risk for thromboembolic complications for surgical patients is high, and effective prophylactic treatment is normally and systematically prescribed, the situation is very different regarding patients admitted in a internal medical ward. Only recently the usefulness of prophylactic treatment was recognised also for medical patients. A thromboembolic event can be a life threatening complication especially for people affected by chronic obstructive pulmonary disease (COPD) that represents a significant part of medical hospitalised patients. Moreover symptoms and signs related to the chronic pulmonary disease can be confusing factors that may delay a timely and correct diagnosis of a thromboembolic complication.
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Gazizianova, V. M., O. V. Bulashova, E. V. Khazova, A. A. Nasybullina i M. I. Malkova. "Heart rate variability in patients with chronic heart failure and chronic obstructive pulmonary disease: clinical parallels". Kazan medical journal 97, nr 3 (15.06.2016): 421–25. http://dx.doi.org/10.17750/kmj2016-421.
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Diseases comorbidity issues are of concern of many researchers, in recent decades, there are attempts to understand the hierarchy of diseases cause-and-effect relationships. Integrative approach to the patient’s condition assessment, whose comorbidity index increases with aging, is of great practical importance, since it allows the practitioner to choose the best drug therapy strategy and to objectively assess the risk of adverse cardiovascular events. Cardiovascular diseases, including those associated with bronchopulmonary system diseases, occupy leading position in mortality rate. One of the most common combinations in clinical practice is a combination of heart failure and chronic obstructive pulmonary disease. Their pathogenetic relationship may be due to common for diseases neurohumoral imbalance. The review presents data on the prevalence and mortality of patients with congestive heart failure and chronic obstructive pulmonary disease, describes the importance of autonomic nervous system dysfunction assessment in cardiovascular and bronchopulmonary diseases combination. Data on the heart rate variability assessment informativeness from the perspective of the clinical characteristics determination relevance and prognosis in patients with congestive heart failure and chronic obstructive pulmonary disease are presented. The main assessed time-domain and spectral parameters are narrated. The results of the heart rate variability parameters study in multicenter clinical trials in patients groups with heart failure and bronchopulmonary obstruction, which define the clinical and prognostic predictors among the heart rate variability parameters, are presented. In general, information on heart rate variability in congestive heart failure in comorbidity with chronic obstructive pulmonary disease is scantily presented in the available literature.
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Müller, Veronika, Gabriella Gálffy i Lilla Tamási. "Asthma and chronic obstructive pulmonary disease overlap". Orvosi Hetilap 152, nr 3 (styczeń 2011): 114–18. http://dx.doi.org/10.1556/oh.2011.29025.
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Asthma bronchiale and chronic obstructive pulmonary disease are the most prevalent lung diseases characterized by inflammation of the airways. International and Hungarian guidelines privide proper definitions for clinical symptoms, diagnostics and therapy of both diseases. However, in everyday clinical practice, overlap of asthma and chronic obstructive pulmonary disease has become more frequent. As guidelines are mainly based on large, multicenter, randomized, controlled trials that exclude overlap patients, there is a lack of diagnostic and especially therapeutic strategies for these patients. This review summarizes clinical characteristics of asthma and chronic obstructive pulmonary disease overlap, and provides daily practical examples for its management. Orv. Hetil., 2011, 152, 114–118.
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Lіakh, O. I., M. I. Tovt-Korshуnska i M. A. Derbak. "Clinical Characteristics of the Combined Course of Chronic Obstructive Pulmonary Disease and Gastroesophagal Reflux Disease". Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 6, nr 4 (18.09.2021): 91–98. http://dx.doi.org/10.26693/jmbs06.04.091.
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The comorbid diseases can occur at any stage of bronchial obstruction, and, regardless of the severity or phase of chronic obstructive pulmonary disease, significantly affect disability, increase the frequency of hospitalizations, and increase the cost of medical care. The presence of concomitant gastroesophageal reflux disease in patients with chronic obstructive pulmonary disease is an independent aggravating risk factor for exacerbations and is associated with health deterioration of this group of patients. The purpose of the study was to study the features of the clinical course of chronic obstructive pulmonary disease in combination with gastroesophageal reflux disease. Materials and methods. Retrospective analysis of 138 patients who were treated in the pulmonology department for exacerbation of the disease and outpatient treatment by a gastroenterologist was carried out. 3 groups of patients were formed: 1 group (n=60) – patients with chronic obstructive pulmonary disease in combination with gastroesophageal reflux disease, 2 group (n=42) – patients with chronic obstructive pulmonary disease without signs of gastroesophageal reflux disease, who were treated in the pulmonology department for exacerbation of the disease and 3 group (n=36) – patients with gastroesophageal reflux disease who were treated on an outpatient basis. The patients were similar in age, stage of disease and duration of illness. The average age of the patients was 55±1.64. It should be noted, regarding the gender characteristics of the groups, that among the examined patients by gender, men predominated – 78.4% (80 out of 102). Results and discussion. The main clinical and anamnestic features of the combined pathology were studied. The significance of the assessment of functional changes in spirometry indexes in this category of patients is described. A significant decrease in external respiration function was revealed in the indicators of the external respiration function in patients of all groups. In the patients with chronic obstructive pulmonary disease in combination with gastroesophageal reflux disease the frequency of exacerbations increases. These exacerbations were associated with the presence and severity of gastrointestinal symptoms, namely increased heartburn, acid regurgitation causes worsening of respiratory symptoms, until the exacerbation of the disease with subsequent hospitalization. Also the length of stay in the hospital of the patients in this group increased by 1.5±0.4 days, which is associated with a severe exacerbation of chronic obstructive pulmonary disease and the need to use a double dose of glucocorticoids to control the symptoms of respiratory failure. Among the complaints of patients with combined pathology, extraesophageal manifestations of gastroesophageal reflux disease prevailed. Conclusion. The presence of concomitant gastroesophageal reflux disease in patients with chronic obstructive pulmonary disease expands and aggravates the clinical manifestations of the underlying disease
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Faludi, Réka. "Chronic obstructive pulmonary disease: a cardiologist’s point of view". Orvosi Hetilap 155, nr 37 (wrzesień 2014): 1480–84. http://dx.doi.org/10.1556/oh.2014.29989.
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Chronic obstructive pulmonary disease is often associated with cardiovascular diseases, such as pulmonary hypertension, ischemic heart disease, arrhythmias or heart failure. These co-morbidities may cause diagnostic or therapeutic difficulties and significantly worsen the morbidity and mortality of patients with chronic obstructive pulmonary disease. In this work the author reviews special considerations for the treatment of patients with chronic obstructive pulmonary disease who have cardiovascular co-morbidities. Orv. Hetil., 2014, 155(37), 1480–1484.
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Ono, Manabu, Seiichi Kobayashi, Masakazu Hanagama, Masatsugu Ishida, Hikari Sato, Tomonori Makiguchi i Masaru Yanai. "Clinical characteristics of Japanese patients with chronic obstructive pulmonary disease (COPD) with comorbid interstitial lung abnormalities: A cross-sectional study". PLOS ONE 15, nr 11 (10.11.2020): e0239764. http://dx.doi.org/10.1371/journal.pone.0239764.
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Smoking-related interstitial lung abnormalities are different from specific forms of fibrosing lung disease which might be associated with poor prognoses. Chronic obstructive pulmonary disease with comorbid interstitial lung abnormalities and that with pulmonary fibrosis are considered different diseases; however, they could share a common spectrum. We aimed to evaluate the clinical characteristics of Japanese patients with chronic obstructive pulmonary disease and comorbid interstitial lung abnormalities. In this prospective observational study, we analyzed data from the Ishinomaki COPD Network Registry. We evaluated the clinical characteristics of patients with chronic obstructive pulmonary disease with and without comorbid interstitial lung abnormalities by comparing the annualized rate of chronic obstructive pulmonary disease exacerbations per patient during the observational period. Among 463 patients with chronic obstructive pulmonary disease, 30 (6.5%) developed new interstitial lung abnormalities during the observational period. After 1-to-3 propensity score matching, we found that the annualized rate of chronic obstructive pulmonary disease exacerbations per patient during the observational period was 0.06 and 0.23 per year in the interstitial lung abnormality and control groups, respectively (P = 0.043). Our findings indicate slow progression of interstitial lung abnormality lesions in patients with pre-existing chronic obstructive pulmonary disease. Further, interstitial lung abnormality development did not significantly influence on chronic obstructive pulmonary disease exacerbation. We speculate that post-chronic obstructive pulmonary disease interstitial lung abnormalities might involve smoking-related interstitial fibrosis, which is different from specific forms of fibrosing lung disease associated with poor prognoses.
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Lapteva, E. A., I. M. Lapteva i O. N. Kharevich. "Systemic manifestations in different stages of chronic obstructive pulmonary disease". Kazan medical journal 94, nr 5 (15.10.2013): 605–9. http://dx.doi.org/10.17816/kmj1901.
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Aim. To reveal the systemic manifestations of chronic obstructive pulmonary disease and to match them with respiratory function parameters and extrapulmonary manifestations as the disease progresses. Methods. 160 patients were examined (128 patients with different stages of chronic obstructive pulmonary disease - the study group, and 32 healthy volunteers - the control group). Clinical examination, serum cytokine concentration measurement, lung function tests, airway resistance and lung volumes evaluation, assessment of hemodynamic parameters, bone mineral density assessment were conducted. Correlations between listed parameters were estimated. Results. It was found that the activation of systemic inflammation occurs at the early stages of the disease with the further increase as it progresses, as was shown by the increase of interleukin-6, interleukin-8, tumor necrosis factor alpha (TNF-α), C-reactive protein levels in the study group compared to the control. The relation between spirometry parameters and inflammatory markers confirmed the role of systemic inflammation in chronic obstructive pulmonary disease progression and cardiovascular complications development. A correlation between the C-reactive protein level and forced expiratory volume at 1st second (FEV 1), as well as between TNF-α level and FEV 1, TNF-α level and lung vital capacity was found. The study also confirmed the role of lung hyperinflation in pulmonary hypertension and chronic cor pulmonale occurrence and progression: mean pulmonary arterial pressure correlated with residual volume to total lung capacity ratio in patients with FEV 1 50% and in patients with FEV 1 50%. Significant correlations between lung function and parameters of pulmonary hemodynamics (FEV 1 with right ventricular end-diastolic dimension) were revealed. Correlations between femoral neck bone mineral density and residual lung volume and diffusing lung capacity confirmed the role of progressive emphysema and hypoxia in the pathogenesis of osteoporosis in patients with chronic obstructive pulmonary disease. Conclusion. Correlations between the severity of airway obstruction and systemic manifestations of chronic obstructive pulmonary disease were revealed.
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Odler, Balázs, i Veronika Müller. "Asthma-COPD overlap szindróma". Orvosi Hetilap 157, nr 33 (sierpień 2016): 1304–13. http://dx.doi.org/10.1556/650.2016.30520.
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Obstructive lung diseases represent a major health problem worldwide due to their high prevalence associated with elevated socioeconomic costs. Bronchial asthma and chronic obstructive pulmonary disease are chronic obstructive ventilatory disorders with airway inflammation, however they are separate nosological entities based on thedifferent development, diagnostic and therapeutic approaches, and prognostic features. However, these diseases may coexist and can be defined as the coexistence of increased variability of airflow in a patient with incompletely reversible airway obstruction. This phenotype is called asthma – chronic obstructive pulmonary disease overlap syndrome. The syndrome is a clinical and scientific challenge as the majority of these patients have been excluded from the clinical and pharmacological trials, thus well-defined clinical characteristics and therapeutic approaches are lacking. The aim of this review is to summarize the currently available literature focusing on pathophysiological and clinical features, and discuss possible therapeutic approaches of patients with asthma – chronic obstructive pulmonary disease overlap syndrome. Orv. Hetil., 2016, 157(33), 1304–1313.
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Lee, Ruth, i Walter T. McNicholas. "Obstructive sleep apnea in chronic obstructive pulmonary disease patients". Current Opinion in Pulmonary Medicine 17, nr 2 (marzec 2011): 79–83. http://dx.doi.org/10.1097/mcp.0b013e32834317bb.
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Fuaad, Muazzam, Waheed Iqbal, Muhammad Omar Khan, Amjad Ali, Muhammad Imran i Muhammad Shahbaz Ashraf. "Prevalence of Gastroesophageal Reflux Disease in Asthma and Chronic Obstructive Pulmonary Disease". Pakistan Journal of Medical and Health Sciences 15, nr 9 (30.09.2021): 2568–71. http://dx.doi.org/10.53350/pjmhs211592568.
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Background: The esophagus exposure to stomach reflexes contents (or gastric content) causes an inflammatory sensation, bitter fluid movement from the abdomen to mouth and other troublesome symptoms are generally referred to as Gastro esophageal reflux disease (GERD). Aims: The present study aimed to evaluate the prevalence of gestroesophageal reflux disease in asthma and chronic obstructive pulmonary disease. Materials and Methods: This multi-center cross-sectional study was carried out on 150 chronic obstructive pulmonary disease patients admitted at Medicine ward and OPD at Divisional Headquarters Teaching hospital Mirpur and KMU IMS, Kohat for six months duration from October 2020 to March 2021. All the patients of either gender having an age range between 16-70 years and met the inclusive criteria were enrolled. The demographic details such as age, gender, duration, and severity of chronic obstructive pulmonary disease, and Gastroesophageal reflux disease prevalence were recorded in proforma after obtaining informed consent in written form. Patients with a ratio of forced expiratory volume to forced vital capacity (<70%) in one second and had no forced expiratory volume improvement after nebulization. SPSS version 20 was used for data analysis. Results: Of the total 150 chronic obstructive pulmonary disease patients, 93 (62%) were male while females were 57 (38%). The overall mean age ±SD was 54.37±16.06 years. Chronic obstructive pulmonary disease mean duration was 8.93±5.3 years. Out of 150 COPD patients, about 74 (49.3%) had Gastroesophageal reflux disease while 76 (51.7%) had no Gastroesophageal reflux disease. The GERD overall prevalence in COPD was 49.3%. Based on Gastroesophageal reflux disease symptoms, very severe, severe, moderate, and mild were 26 (17.6%), 23 (15.4%), 14 (9%), and 11 (7.3%) respectively. As per COPD severity, the prevalence of GERD was statistically insignificant (p-0.532). Conclusion: The present study concluded a significant association between chronic obstructive pulmonary diseases with gastro esophageal reflux disease. The prevalence of gastro esophageal reflux disease was reported at 49.3% among chronic obstructive pulmonary diseases patients. Keywords: Gastroesophageal reflux, chronic obstructive pulmonary disease, Asthma
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Milic-Emili, Joseph. "Inspiratroy Capacity and Exercise Tolerance in Chronic Obstructive Pulmonary Disease". Canadian Respiratory Journal 7, nr 3 (2000): 282–85. http://dx.doi.org/10.1155/2000/745686.
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During the past half-century, many studies have investigated the correlation of exercise tolerance to routine lung function in patients with obstructive pulmonary disease. In virtually all of these studies, the degree of airway obstruction was assessed in terms of forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC). Because in most studies only a weak correlation was found between exercise tolerance and degree of airway obstruction, it has been concluded that factors other than lung function impairment (eg, deconditioning and peripheral muscle dysfunction) play a predominant role in limiting exercise capacity in patients with chronic airway obstruction. Recent work, however, suggests that in patients with chronic obstructive pulmonary disease, the inspiratory capacity is a more powerful predictor of exercise tolerance than FEV1 and FVC.
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Tahasildar, Kunal K., i Jagannath S. Shete. "The clinical profile of obstructive lung diseases patients attending tertiary care hospital in Nanded, Maharashtra: an observational study". International Journal of Research in Medical Sciences 6, nr 12 (26.11.2018): 3970. http://dx.doi.org/10.18203/2320-6012.ijrms20184892.
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Background: Obstructive lung diseases as asthma and Chronic Obstructive Pulmonary Disease (COPD) have considerable morbidity and mortality globally. Chronic obstructive pulmonary disease (COPD) remains a major public health problem. It is projected to rank fifth in 2020 in burden of disease worldwide, according to the WHO study. Aim and objectives was to evaluate clinical profiles of obstructive lung diseases patients attending tertiary care hospital.Methods: The data was collected from 112 obstructive lung diseases patients presenting to OPD of pulmonary medicine department from January 2009 to August 2010. Research tool comprised of questions about demographic characteristics, past or presenting symptoms, general and systemic examinations. For statistical analysis MS Excel and SPSS 16 were used.Results: Overall 72 (64.28%) were smokers. 63 (56.25%) were suffering from COPD and 49 (43.75%) were asthmatic. Breathlessness was found as most common symptom in 53 (84.12%) COPD and in 45 (91.83%) asthma patients. Among COPD patients, 26 (41.26%) were of moderate obstruction whereas in asthma patients, 17 (34.69%) were of moderate obstruction and 16 (32.65%) were of severe obstruction as per Pulmonary Function Tests (PFT).Conclusions: Males were most commonly affected in obstructive lung diseases. COPD was common after 35 years of age where as asthma occurs mostly before 35 years of age. Smoking was most common etiological factor. Breathlessness was the most common presenting symptom. Family history of asthma was most common risk factor for asthma patients. Most of the patients with both COPD as well as asthma had moderate type of obstructions.
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Hodson, Matthew, i Rebecca Sherrington. "Treating patients with chronic obstructive pulmonary disease". Nursing Standard 29, nr 9 (29.10.2014): 50–58. http://dx.doi.org/10.7748/ns.29.9.50.e9061.
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Bender, Bruce G. "Nonadherence in chronic obstructive pulmonary disease patients". Current Opinion in Pulmonary Medicine 20, nr 2 (marzec 2014): 132–37. http://dx.doi.org/10.1097/mcp.0000000000000027.
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Jørgensen, Niklas Rye, i Peter Schwarz. "Osteoporosis in chronic obstructive pulmonary disease patients". Current Opinion in Pulmonary Medicine 14, nr 2 (marzec 2008): 122–27. http://dx.doi.org/10.1097/mcp.0b013e3282f4efb6.
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Olszewska, Jolanta. "Rehabilitation for chronic obstructive pulmonary disease patients". Polish Annals of Medicine 18, nr 1 (styczeń 2011): 177–87. http://dx.doi.org/10.1016/s1230-8013(11)70037-6.
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Cortopassi, Felipe, Puncho Gurung i Victor Pinto-Plata. "Chronic Obstructive Pulmonary Disease in Elderly Patients". Clinics in Geriatric Medicine 33, nr 4 (listopad 2017): 539–52. http://dx.doi.org/10.1016/j.cger.2017.06.006.
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Bagisheva, N. V., A. V. Mordyk, I. A. Viktorova i D. I. Trukhan. "Cardiovascular pathology in patients with newly diagnosed tuberculosis and chronic obstructive pulmonary disease". Meditsinskiy sovet = Medical Council, nr 14 (18.10.2021): 142–48. http://dx.doi.org/10.21518/2079-701x-2021-14-142-148.
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Introduction. Chronic obstructive pulmonary disease and cardiovascular diseases (arterial hypertension, ischemic heart disease, chronic heart failure) are among the comorbid conditions that mutually aggravate each other. The addition of tuberculosis in this category of patients requires additional efforts from the doctor to improve treatment outcomes.Purpose. Тo assess the prevalence of chronic obstructive pulmonary disease, arterial hypertension, coronary heart disease and chronic heart failure in patients with newly diagnosed tuberculosis hospitalized in an anti-tuberculosis hospital.Materials and methods. We examined 462 patients with newly diagnosed tuberculosis, hospitalized in a tuberculosis dispensary, aged 17 to 88 years, the median (Me (P25; 75) age was 43.68 (32.00; 54.00) years, including 266 men (57.6%) and 196 women (42.4%) All patients underwent clinical, laboratory, instrumental examination to establish or confirm the diagnosis.Results. The incidence of chronic obstructive pulmonary disease among patients with newly diagnosed tuberculosis was 31.4%, with arterial hypertension – 12.1%, coronary heart disease – 6.1%, chronic heart failure – 6.1%. The incidence of cardiovascular pathology in the group of tuberculosis + chronic obstructive pulmonary disease was 40%, in the group of tuberculosis without chronic obstructive pulmonary disease 6%.Conclusions. The prevalence of comorbid cardiovascular pathology in patients with tuberculosis + chronic obstructive pulmonary disease is significantly higher than among patients with only tuberculosis, which requires the involvement of doctors of various specialties to manage this category of patients to prevent adverse treatment outcomes, disability and mortality.
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Pal’mova, L. Yu, A. A. Podol’skaya, Z. A. Shaykhutdinova, D. A. Zaplatova i E. B. Druzhkova. "Analysis of admissions with bronchial asthma and chronic obstructive pulmonary disease exacerbations". Kazan medical journal 97, nr 6 (15.12.2016): 958–62. http://dx.doi.org/10.17750/kmj2016-958.
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Aim. To study the factors worsening the course of chronic obstructive pulmonary disease and bronchial asthma.Methods. At the first stage, assessment of 1561 case histories of patients with internal diseases was performed, of whom 341 had lung diseases. A more detailed analysis with the assessment of the clinical characteristics of hospitalized patients was conducted at the second stage of our study, which included evaluation of 38 case histories of patients over a 6-month period in 2016.Results. In the structure of mortality from lung disease chronic obstructive pulmonary disease is the dominant cause (53.8%) predominating deaths from pneumonia (46.2%). Mean age of patients who died from chronic obstructive pulmonary disease was 67.2±5.97 years. Exacerbation of chronic obstructive pulmonary disease was the cause of hospitalization in 24 (63.2%) cases, bronchial asthma in 11 (28.9%) cases, chronic obstructive pulmonary disease and asthma overlap syndrome was observed in 3 (7.9%) cases. Exacerbation of chronic bronchoobstructive pathology was mostly caused by respiratory tract infections (84.2% of cases), which required administration of pluripotent antibacterial therapy. In 60.5% cases deterioration of concomitant diseases was observed with cardiovascular diseases prevailing (arterial hypertension, chronic heart failure decompensation).Conclusion. When organizing the strategy of urgent care for patients with chronic bronchoobstructive diseases, paying more attention to assessment of comorbidities is relevant; it is critical to raise awareness of practicing physicians of the criteria for the diagnosis of asthma and chronic obstructive pulmonary disease overlap syndrome.
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Aisanov, Z. R., A. G. Chuchalin i E. N. Kalmanova. "Chronic obstructive pulmonary disease and cardiovascular comorbidity". Kardiologiia 59, nr 8S (16.09.2019): 24–36. http://dx.doi.org/10.18087/cardio.2572.
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In recent years, a greater understanding of the heterogeneity and complexity of chronic obstructive pulmonary disease (COPD) has come from the point of view of an integrated clinical assessment of severity, pathophysiology, and the relationship with other pathologies. A typical COPD patient suffers on average 4 or more concomitant diseases and every day about a third of patients take from 5 to 10 different drugs. The mechanisms of the interaction of COPD and cardiovascular disease (CVD) include the effects of systemic inflammation, hyperinflation (hyperinflation) of the lungs and bronchial obstruction. The risk of developing CVD in patients with COPD is on average 2–3 times higher than in people of a comparable age in the general population, even taking into account the risk of smoking. The prevalence of coronary heart disease, heart failure, and rhythm disturbances among COPD patients is significantly higher than in the general population. The article discusses in detail the safety of prescribing various groups of drugs for the treatment of CVD in patients with COPD. Achieving success in understanding and managing patients with COPD and CVD is possible using an integrated multidisciplinary approach.
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M. Ali, Kosar M. Ali, Shirwan H. Omer H. Omer i Razhan Y. Abdalla Y. Abdalla. "NON INVASIVE DIAGNOSIS AND ASSESSMENT OF THE SEVERITY OF PULMONARY HYPERTENSION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE". Journal of Sulaimani Medical College 9, nr 1 (21.03.2019): 1–10. http://dx.doi.org/10.17656/jsmc.10184.
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Nikolaieva, K. L. "Dynamics of Inflammatory Markers in Patients with Pulmonary Hypertension on the Background of COPD combined with Hypertension under the Influence of Treatment". Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 5, nr 6 (12.12.2020): 150–57. http://dx.doi.org/10.26693/jmbs05.06.150.
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Chronic obstructive pulmonary disease significantly affects the quality of life, considerably limiting the physical capabilities of patients and is one of the main causes of morbidity and mortality in modern society. Currently, the problem of the comorbidity for the patients with chronic obstructive pulmonary disease is very relevant. The most common in patients of this category is hypertension. Today, it has been established that disorders in the immune system are detected in a very large group of diseases, including both chronic obstructive pulmonary disease and hypertension. The purpose of the study was to evaluate the dynamics of inflammatory markers in the patients with pulmonary hypertension on the background of chronic obstructive pulmonary disease in combination with hypertension under the influence of treatment. Material and methods. The results of the study are based on data from a comprehensive survey of 170 patients aged 40 to 65 years with chronic obstructive pulmonary disease, of which 123 had pulmonary hypertension (of which 87 had stage II hypertension and 36 were without hypertension) and 47 people were without pulmonary hypertension. The patients were chosen in the period from 2015 to 2018 on the basis of the municipal institution "Zaporizhzhia regional clinical hospital" of the Zaporizhzhia regional council. Results and discussion. The results of this study indicate the role of inflammation, or rather the levels of hs-CRP and IL-6, in the pathogenesis of pulmonary hypertension in patients with chronic obstructive pulmonary disease. The level of hs-CRP among the patients with pulmonary hypertension on a background of chronic obstructive pulmonary disease made up 10.46 [6,24 ; 15,30] mg/l and was significantly higher as against the values in the group of patients with chronic obstructive pulmonary disease without pulmonary hypertension and compared with group of healthy persons. The increase in the level of IL-6 in the group of patients having pulmonary hypertension with chronic obstructive pulmonary disease is significantly higher by 57 % compared to the value in the group of chronic obstructive pulmonary disease without pulmonary hypertension and by 7.4 times the value in the group of healthy individuals (p <0.05). Comparing the subgroups of patients, and depending on the variant of exacerbation of chronic obstructive pulmonary disease, the level of hs-CRP and IL-6 was considerably higher in the subgroup with the infectious type of exacerbation compared with the subgroup of the non-infectious type of exacerbation of chronic obstructive pulmonary disease. Conclusion. After 12 months of treatment, when roflumilast was added to the basic therapy, we revealed a statistically significant difference in the levels of IL-6, hs-CRP and IL-10 in the plasma of patients with pulmonary hypertension on the background of chronic obstructive pulmonary disease combined with hypertension
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Sarkar, Malay, Rajeev Bhardwaj, Irappa Madabhavi i Jasmin Khatana. "Osteoporosis in Chronic Obstructive Pulmonary Disease". Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine 9 (styczeń 2015): CCRPM.S22803. http://dx.doi.org/10.4137/ccrpm.s22803.
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Chronic obstructive pulmonary disease (COPD) is a lifestyle-related chronic inflammatory pulmonary disease associated with significant morbidity and mortality worldwide. COPD is associated with various comorbidities found in all stages of COPD. The comorbidities have significant impact in terms of morbidity, mortality, and economic burden in COPD. Management of comorbidities should be incorporated into the comprehensive management of COPD as this will also have an effect on the outcome in COPD patients. Various comorbidities reported in COPD include cardiovascular disease, skeletal muscle dysfunction, anemia, metabolic syndrome, and osteoporosis. Osteoporosis is a significant comorbidity in COPD patients. Various risk factors, such as tobacco smoking, systemic inflammation, vitamin D deficiency, and the use of oral or inhaled corticosteroids (ICSs) are responsible for its occurrence in patients with COPD. This review will focus on the prevalence, pathogenesis, risk factors, diagnosis, and treatment of osteoporosis in COPD patients.
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Shmeleva, N. M., V. P. Sidorova, A. S. Belevsky i E. I. Shmelev. "Chronic obstructive pulmonary disease in ambulatory practice". PULMONOLOGIYA, nr 6 (28.12.2008): 29–33. http://dx.doi.org/10.18093/0869-0189-2008-0-6-29-33.
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Quality of outpatient management of patients with chronic obstructive pulmonary disease (COPD) and ways to improve it have been studied in this trial. The study included analysis of 560 medical recorders of outpatients followed up in one and the same outpatient clinic by one and the same physician for 5 to 10 yrs and who were currently newly diagnosed for COPD, epidemiological investigation using questionnaire and spirometry in all patients attending the outpatient clinic, and organization of educational COPD center for physicians, nurses and patients. We assessed concordance of the patients' management according to medical records to national guidelines. Most frequent discrepancies were inaccurate recording of the patient's symptoms and history, incomplete and inadequate examination, incorrect diagnosis, inadequate therapy. Functional disorders were not estimated in 95.9 % of the patients, COPD stage was not determined in 100 % of the cases, severity was not assessed in 83.9 %, and 70.7 % of the patients were not diagnosed for complications and exacerbations of the disease. Inhaled bronchodilators were not administered in 41.9 % of the patients, 90 % of the patients were inadequately treated with antibiotics, 100 % of the patients were not vaccinated. The main reasons for this mismatching were thought to be poor awareness of COPD by physicians, lack of pneumologists in outpatient clinics, and insufficient technical provision of the outpatients clinics with spirographs, oxymeters, etc. The epidemiological examination involved 8 672 patients, among them 38 % reported respiratory symptoms and 24 % had ventilatory disorders. COPD was firstly diagnosed in 768 patients. Implementation of educational programmes have led to necessary functional investigations to be used twice more frequent.
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Purushothaman, Sangeetha. "Adverse Drug Reaction Monitoring in Chronic Obstructive Pulmonary Disease Patients in a Tertiary Care Centre". Journal of Medical Science And clinical Research 05, nr 04 (4.04.2017): 19884–89. http://dx.doi.org/10.18535/jmscr/v5i4.28.
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