Gotowe bibliografie tematyczne / CGH

Gotowa bibliografia na temat „CGH”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 11 marca 2023

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Artykuły w czasopismach na temat "CGH"

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Caliebe, A., K. Platzer, L. Argyriou, S. Bens, Y. Hellenbroich, N. Husemeyer, I. Nagel i in. "Array-CGH". medizinische genetik 24, nr 2 (czerwiec 2012): 99–107. http://dx.doi.org/10.1007/s11825-012-0330-3.

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Autio, R., S. Hautaniemi, P. Kauraniemi, O. Yli-Harja, J. Astola, M. Wolf i A. Kallioniemi. "CGH-Plotter: MATLAB toolbox for CGH-data analysis". Bioinformatics 19, nr 13 (1.09.2003): 1714–15. http://dx.doi.org/10.1093/bioinformatics/btg230.

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Sifre, Vicente, Carme Soler, Sergi Segarra, José Ignacio Redondo, Luis Doménech, Amadeo Ten-Esteve, Laura Vilalta, Luis Pardo-Marín i Claudio Iván Serra. "Improved Joint Health Following Oral Administration of Glycosaminoglycans with Native Type II Collagen in a Rabbit Model of Osteoarthritis". Animals 12, nr 11 (30.05.2022): 1401. http://dx.doi.org/10.3390/ani12111401.

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A prospective, experimental, randomized, double blinded study was designed to evaluate the effects of glycosaminoglycans, with or without native type II collagen (NC), in an osteoarthritis model induced by cranial cruciate ligament transection. The following compounds were tested: chondroitin sulfate (CS), glucosamine hydrochloride (GlHCl), hyaluronic acid (HA) and NC. Fifty-four female 12-week-old New Zealand rabbits were classified into three groups: CTR (control–no treatment), CGH (CS + GlHCl + HA) and CGH-NC (CS + GlHCl + HA + NC). Each group was subdivided into three subgroups according to survival times of 24, 56 and 84 days. Over time, all rabbits developed degenerative changes associated with osteoarthritis. CGH-NC showed significantly improved values on macroscopic evaluation, compared to CTR and CGH. Microscopically, significantly better results were seen with CGH and CGH-NC, compared to CTR, and synovial membrane values were significantly better with CGH-NC compared to CGH. A significant improvement in magnetic resonance imaging biomarkers was also observed with CGH-NC in cartilage transversal relaxation time (T2) and subchondral bone D2D fractal dimension in the lateral condyle. In conclusion, our results show beneficial effects on joint health of CGH and CGH-NC and also supports that adding NC to CGH results in even greater efficacy.
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Farmer, Peter K., Suzanne J. Snodgrass, Anthony J. Buxton i Darren A. Rivett. "An Investigation of Cervical Spinal Posture in Cervicogenic Headache". Physical Therapy 95, nr 2 (1.02.2015): 212–22. http://dx.doi.org/10.2522/ptj.20140073.

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Background Cervicogenic headache (CGH) is defined as headache symptoms originating from the cervical spine. Cervical dysfunction from abnormal posture has been proposed to aggravate or cause CGH, but there are conflicting reports as to whether there is an association between posture and CGH. Objective The purpose of this study was to evaluate differences in cervical spinal posture, measured on radiographs, between patients with probable CGH and asymptomatic control participants. Design A single-blinded comparative measurement design was used. Methods Differences in postural variables from radiographs between participants with CGH (n=30) and age- and sex-matched asymptomatic control participants (n=30) were determined using paired t tests or the nonparametric equivalent. Postural variables were general cervical lordosis (GCL, Cobb angle C2–C7), upper cervical lordosis (UCL, sagittal alignment C2 compared with C3–C4), and C2 spinous process horizontal deviation. Logistic regression determined postural variables, increasing the likelihood of CGH. Results There were no significant differences in posture between the CGH and control groups. The mean GCL was 10.97 degrees (SD=7.50) for the CGH group and 7.17 degrees (SD=5.69) for the control group. The mean UCL was 11.86 degrees (SD=6.46) for the CGH group and 9.44 degrees (SD=4.28) for the control group. The mean C2 spinous process horizontal deviation was 3.00 mm (SD=1.66) for the CGH group and 2.86 mm (SD=2.04) for the control group. However, there was a significant association between greater GCL and an increased likelihood of having CGH (odds ratio=1.08; 95% confidence interval=1.001, 1.191). Limitations The findings are limited to an association between GCL and posture, as cause and effect cannot be determined. Conclusions The association between greater GCL and increased likelihood of having CGH suggests that GCL might be considered in the treatment of patients with CGH. However, as the data do not support posture as a cause of CGH, it is unknown whether addressing posture would reduce CGH.
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Bejjani, Bassem A., i Lisa G. Shaffer. "Targeted Array CGH". Journal of Molecular Diagnostics 8, nr 5 (listopad 2006): 537–39. http://dx.doi.org/10.1016/s1525-1578(10)60341-8.

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Lingjaerde, O. C., L. O. Baumbusch, K. Liestol, I. K. Glad i A. L. Borresen-Dale. "CGH-Explorer: a program for analysis of array-CGH data". Bioinformatics 21, nr 6 (5.11.2004): 821–22. http://dx.doi.org/10.1093/bioinformatics/bti113.

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Sudar, Damir, Lucas van Vliet, Steve Clark, Rick Segraves, Stephen Lockett, Donna Albertson, Joe Gray i Pinkel Daniel. "Design of a Wide Field High Sensitivity Imaging System for Quantitative Analysis of CGHA Micro-Arrays." Microscopy and Microanalysis 3, S2 (sierpień 1997): 811–12. http://dx.doi.org/10.1017/s1431927600010941.

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Comparative Genomic Hybridization (CGH) is a quantitative technique for determining relative copy numbers of DNA sequences in whole-genomic test samples. In conventional CGH, test DNA labelled with one fluorochrome and reference DNA labelled with a spectrally different fluorochrome are hybridized to metaphase chromosomes. by measuring the ratio of intensities of the two fluorochromes, a relative copy number of sequences in the test DNA can be calculated for each point along each chromosome. While this approach is very useful for rapid surveying of the entire test genome, the spatial and dynamic resolution are compromised by the dense packing of DNA in the metaphase state. CGHa (array-based CGH) uses spots of cloned DNA arrayed onto a microscope slide which represent the entire genome or interesting sections thereof. Spatial resolution and dynamic range are now only limited by the size of the clones used. See the abstract by Pinkel et al. for more detail.We designed an imaging system for analyzing fluorescence signals from micro-arrays containing targets on the order of 100μm in diameter spaced at similar intervals.
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Sze, Jyh Rou, i An Chi Wei. "Development of a Computer Generation Holography for Generating Square Matrix Light Spots Applied to the Laser Patterning System". Key Engineering Materials 656-657 (lipiec 2015): 509–14. http://dx.doi.org/10.4028/www.scientific.net/kem.656-657.509.

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A computer generation holography (CGH) is proposed herein to synthesize square-matrix light spots. Such a design of CGH is possible by reducing the 2-D problem to two 1-D problems. The both 1-D CGHs are designed with the conjugate-gradient method and verified with the Fresnel-Kirchhoff diffraction theory. This quantized 8-levels CGH is fabricated by using optical contact lithography and reactive-ion etching techniques. Measurement demonstrates that the fabricated CGH has the desired optical function, i.e., it forms square-matrix light spots in the image plane at a distance of 40 mm from the CGH. The developed CGH can be applied to the laser patterning system by optical projection and direct etching.
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Zhang, Yixin, Mingkun Zhang, Kexuan Liu, Zehao He i Liangcai Cao. "Progress of the Computer-Generated Holography Based on Deep Learning". Applied Sciences 12, nr 17 (26.08.2022): 8568. http://dx.doi.org/10.3390/app12178568.

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With the explosive developments of deep learning, learning–based computer–generated holography (CGH) has become an effective way to achieve real–time and high–quality holographic displays. Plentiful learning–based methods with various deep neural networks (DNNs) have been proposed. In this paper, we focus on the rapid progress of learning–based CGH in recent years. The generation principles and algorithms of CGH are introduced. The DNN structures frequently used in CGH are compared, including U–Net, ResNet, and GAN. We review the developments and discuss the outlook of the learning–based CGH.
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Dietzel, Matthias, Clemens Kaiser, Katja Pinker, Evelyn Wenkel, Matthias Hammon, Michael Uder, Barbara Bennani Baiti, Paola Clauser, Rüdiger Schulz-Wendtland i Pascal Baltzer. "Automated Semi-Quantitative Analysis of Breast MRI: Potential Imaging Biomarker for the Prediction of Tissue Response to Neoadjuvant Chemotherapy". Breast Care 12, nr 4 (2017): 231–36. http://dx.doi.org/10.1159/000480226.

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Background: We aimed to investigate an automated semi-quantitative software as an imaging biomarker for the prediction of tissue response (TR) after completion of neoadjuvant chemotherapy (NAC). Methods: Breast magnetic resonance imaging (MRI) (1.5T, protocol according to international recommendations) of 67 patients with biopsy-proven invasive breast cancer were examined before and after NAC. After completion of NAC, histopathologic assessments of TR were classified according to the Chevallier grading system (CG1/4: full/non-responder; CG2/C3: partial responder). A commercially available fully automatic software (CADstream) extracted MRI parameters of tumor extension (tumor diameter/volume: TD/TV). Pre- versus post-NAC values were compared (ΔTV and ΔTD). Additionally, the software performed volumetric analyses of vascularization (VAV) after NAC. Accuracy of MRI parameters to predict TR were identified (cross-tabs, ROC, AUC, Kruskal-Wallis). Results: There were 37 (34.3%) CG1, 7 (6.5%) CG2, 53 (49.1%) CG3, and 11 (10.2%) CG4 lesions. The software reached area under the curve levels of 79.5% (CG1/complete response: ΔTD), 68.6% (CG2, CG3/partial response: VAV), and 88.8% to predict TR (CG4/non-response: ΔTV). Conclusion: Semi-quantitative automated analysis of breast MRI data enabled the prediction of tissue response to NAC.
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Rozprawy doktorskie na temat "CGH"

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Frater, Eric, i Eric Frater. "Optical Alignment with CGH Phase References". Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/621452.

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The growing field of high-order aspheric and freeform optical fabrication has inspired the creation of optical surfaces and systems which are difficult to align. Advances in optical alignment technology are critical to fabricating and integrating aspheric components in advanced optical systems. This dissertation explores the field of optical alignment with a computer-generated hologram (CGH) used as a reference. A CGH is a diffractive optic which may be used to create a desired phase profile across a beam of light, project irradiance patterns, or serve as a mask for an incident beam. The alignment methods presented in this dissertation are concerned with the use of a CGH to create reference phase profiles, or "wavefronts" , in a beam. In one application a set of axisymmetric CGH references are co-aligned. Each CGH has also been aligned to an aspheric mirror so the co-alignment of the CGH references is also a co-alignment of the aspheric mirrors. Another application is concerned with aligning an interferometer to test an aspheric mirror surface. The interferometer measures a "null" interference pattern when its wavefront accommodates a known surface profile. In this alignment application the CGH creates wavefronts which accommodate a known set of small spherical reference features at the test surface. An interference null from all the "phase fiducial" reference features indicates an aligned projection of the CGH. The CGH co-alignment method is implemented on a 4-mirror prime focus corrector known as the Hobby-Eberly Telescope Wide Field Corrector (HET WFC). It is shown that this method was very successful for centration alignment of some mirrors, whereas mechanical stability was the hardware limitation for other degrees of freedom. The additional alignment methods used in this project are described in detail and the expected alignment of the HET WFC is reported.The fabrication, characterization and application of spherical phase fiducials is demonstrated in a CGH-corrected Fizeau test prototype. It is shown that these reference features achieve <±1.5µm transverse alignment precision. A pair of phase fiducials is also applied to constrain the clocking and magnification of a projected wavefront. Fabrication and coordinate measurement of the features present the dominant challenges in these demonstrations.
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Paiva, Greicy Helen Gambarini [UNESP]. "Genes candidatos a marcadores tumorais na progressão do adenocarcinoma de próstata indentificados por análise de HR-CGH e CGH-ARRAY". Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/102718.

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Made available in DSpace on 2014-06-11T19:32:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-01Bitstream added on 2014-06-13T19:02:40Z : No. of bitstreams: 1 paiva_ghrg_dr_botib.pdf: 1701322 bytes, checksum: d1fa5b5c562a2a6ce8ad0d14ab948d4a (MD5)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O câncer de próstata (CaP) é a neoplasia mais comumente diagnosticada entre homens no ocidente. Embora tratamentos efetivos para a doença localizada estejam disponíveis atualmente, não há terapia curativa para tumores metastáticos. Além disso, os marcadores diagnósticos utilizados na clínica não conseguem discriminar totalmente a evolução diferencial da doença. Desta forma, o conhecimento das diferenças biológicas entre tumores primários confinados ao órgão e metástases é essencial para o desenvolvimento de novos marcadores e identificação de alvos terapêuticos. Neste estudo a análise baseada na metodologia de HR-CGH cromossômico foi realizada para identificar alterações de ganhos e perdas genômicas em três grupos de amostras: o grupo I, que compreende amostras pareadas de tumor primário e respectivas metástases (11 casos); o grupo II, constituído de pacientes que apresentaram seguimento clínico favorável por mais de 10 anos (5 casos); e o grupo III, constituído por diferentes biópsias do mesmo paciente (5 pacientes com 2 biópsias cada). As amostras foram microdissecadas (amostras a fresco: a partir de lâminas de referência; em blocos de parafina: a laser) e após a obtenção de DNA foram amplificadas (amostras de arquivo: PCR-SCOMP) ou marcadas por nick-translation para a realização de HR-CGH. Os resultados de HR-CGH foram comparados com os dados obtidos da análise de CGH-array num subgrupo de amostras e revelaram concordâncias significativas. Os resultados obtidos na presente investigação revelaram perdas dos cromossomos 1p, 2, 3q, 4p, 5q, 7, 8, 9q, 10q, 11q, 12q, 14q, 15q, 16q, 17q, 18q, 19, 20q e 22q em 80% dos casos avaliados. Além disso, perdas em 17q11.2-25, por exemplo, foram detectadas exclusivamente nos tumores do grupo I e nas suas metástases, e não nos tumores do grupo II, sugerindo que esta alteração deve ser importante...
Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous malignancy and the second leading cause of cancer mortality in men from Occident. Although effective treatments for the localized disease are available, there is no efficient therapy for metastatic tumors. Additionally, clinical diagnostic markers are not able to completely discriminate the differential evolution of the disease. The knowledge of biological differences between localized primary tumors and metastasis can establish new molecular markers and therapeutic targets. In this study, an analysis based on HR-CGH methodology was performed to identify imbalances genomic in three groups of samples: group I, paired samples of primary tumors and its metastasis (11 cases); group II, patients that exhibited favorable follow-up over 10 years (5 cases); and group III, different biopsies from the same patient (5 patients with 2 biopsies each). The tumor samples were submitted to microdissection procedures (fresh samples: from reference slides; paraffin embedded samples: laser), DNA extracted and amplified (archive sample: PCR-SCOMP) or labeled by nick-translation to HR-CGH. The HRCGH results were compared with data obtained from CGH-array analysis of a subgroup of samples and revealed significant concordances. In the present investigation, there were observed losses on chromosomes 1p, 2, 3q, 4p, 5q, 7, 8, 9q, 10q, 11q, 12q, 14q, 15q, 16q, 17q, 18q, 19, 20q and 22q in 80% of the cases. Losses in 17q11.2-25, for instance, were detected exclusively in tumor from group I and its metastasis, but were not found in tumors from group II, suggesting that this alteration must be important in the progression of the disease. Five genes were selected after the comparison between the HR-CGH and CGH-array data. The tumor suppressor genes ARID1A, MTSS1, NME1 and S100A4 and TOP2A (oncogenes) were evaluated by quantitative real time... (Complete abstract click electronic access below)
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Paiva, Greicy Helen Gambarini. "Genes candidatos a marcadores tumorais na progressão do adenocarcinoma de próstata indentificados por análise de HR-CGH e CGH-ARRAY". Botucatu : [s.n.], 2009. http://hdl.handle.net/11449/102718.

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Orientador: Silvia Regina Rogatto
Banca: Spencer L. M. Payão
Banca: Carla Rosemberg
Banca: José Carlos de S. Trindade
Banca: Maria Aparecida M. Rodrigues
Resumo: O câncer de próstata (CaP) é a neoplasia mais comumente diagnosticada entre homens no ocidente. Embora tratamentos efetivos para a doença localizada estejam disponíveis atualmente, não há terapia curativa para tumores metastáticos. Além disso, os marcadores diagnósticos utilizados na clínica não conseguem discriminar totalmente a evolução diferencial da doença. Desta forma, o conhecimento das diferenças biológicas entre tumores primários confinados ao órgão e metástases é essencial para o desenvolvimento de novos marcadores e identificação de alvos terapêuticos. Neste estudo a análise baseada na metodologia de HR-CGH cromossômico foi realizada para identificar alterações de ganhos e perdas genômicas em três grupos de amostras: o grupo I, que compreende amostras pareadas de tumor primário e respectivas metástases (11 casos); o grupo II, constituído de pacientes que apresentaram seguimento clínico favorável por mais de 10 anos (5 casos); e o grupo III, constituído por diferentes biópsias do mesmo paciente (5 pacientes com 2 biópsias cada). As amostras foram microdissecadas (amostras a fresco: a partir de lâminas de referência; em blocos de parafina: a laser) e após a obtenção de DNA foram amplificadas (amostras de arquivo: PCR-SCOMP) ou marcadas por nick-translation para a realização de HR-CGH. Os resultados de HR-CGH foram comparados com os dados obtidos da análise de CGH-array num subgrupo de amostras e revelaram concordâncias significativas. Os resultados obtidos na presente investigação revelaram perdas dos cromossomos 1p, 2, 3q, 4p, 5q, 7, 8, 9q, 10q, 11q, 12q, 14q, 15q, 16q, 17q, 18q, 19, 20q e 22q em 80% dos casos avaliados. Além disso, perdas em 17q11.2-25, por exemplo, foram detectadas exclusivamente nos tumores do grupo I e nas suas metástases, e não nos tumores do grupo II, sugerindo que esta alteração deve ser importante... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous malignancy and the second leading cause of cancer mortality in men from Occident. Although effective treatments for the localized disease are available, there is no efficient therapy for metastatic tumors. Additionally, clinical diagnostic markers are not able to completely discriminate the differential evolution of the disease. The knowledge of biological differences between localized primary tumors and metastasis can establish new molecular markers and therapeutic targets. In this study, an analysis based on HR-CGH methodology was performed to identify imbalances genomic in three groups of samples: group I, paired samples of primary tumors and its metastasis (11 cases); group II, patients that exhibited favorable follow-up over 10 years (5 cases); and group III, different biopsies from the same patient (5 patients with 2 biopsies each). The tumor samples were submitted to microdissection procedures (fresh samples: from reference slides; paraffin embedded samples: laser), DNA extracted and amplified (archive sample: PCR-SCOMP) or labeled by nick-translation to HR-CGH. The HRCGH results were compared with data obtained from CGH-array analysis of a subgroup of samples and revealed significant concordances. In the present investigation, there were observed losses on chromosomes 1p, 2, 3q, 4p, 5q, 7, 8, 9q, 10q, 11q, 12q, 14q, 15q, 16q, 17q, 18q, 19, 20q and 22q in 80% of the cases. Losses in 17q11.2-25, for instance, were detected exclusively in tumor from group I and its metastasis, but were not found in tumors from group II, suggesting that this alteration must be important in the progression of the disease. Five genes were selected after the comparison between the HR-CGH and CGH-array data. The tumor suppressor genes ARID1A, MTSS1, NME1 and S100A4 and TOP2A (oncogenes) were evaluated by quantitative real time... (Complete abstract click electronic access below)
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Shah, Sohrab P. "Model based approaches to array CGH data analysis". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2808.

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DNA copy number alterations (CNAs) are genetic changes that can produce adverse effects in numerous human diseases, including cancer. CNAs are segments of DNA that have been deleted or amplified and can range in size from one kilobases to whole chromosome arms. Development of array comparative genomic hybridization (aCGH) technology enables CNAs to be measured at sub-megabase resolution using tens of thousands of probes. However, aCGH data are noisy and result in continuous valued measurements of the discrete CNAs. Consequently, the data must be processed through algorithmic and statistical techniques in order to derive meaningful biological insights. We introduce model-based approaches to analysis of aCGH data and develop state-of-the-art solutions to three distinct analytical problems. In the simplest scenario, the task is to infer CNAs from a single aCGH experiment. We apply a hidden Markov model (HMM) to accurately identify CNAs from aCGH data. We show that borrowing statistical strength across chromosomes and explicitly modeling outliers in the data, improves on baseline models. In the second scenario, we wish to identify recurrent CNAs in a set of aCGH data derived from a patient cohort. These are locations in the genome altered in many patients, providing evidence for CNAs that may be playing important molecular roles in the disease. We develop a novel hierarchical HMM profiling method that explicitly models both statistical and biological noise in the data and is capable of producing a representative profile for a set of aCGH experiments. We demonstrate that our method is more accurate than simpler baselines on synthetic data, and show our model produces output that is more interpretable than other methods. Finally, we develop a model based clustering framework to stratify a patient cohort, expected to be composed of a fixed set of molecular subtypes. We introduce a model that jointly infers CNAs, assigns patients to subgroups and infers the profiles that represent each subgroup. We show our model to be more accurate on synthetic data, and show in two patient cohorts how the model discovers putative novel subtypes and clinically relevant subgroups.
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Ghaffari, Saeed R. "Development and application of comparative genomic hybridisation (CGH)". Thesis, University of Glasgow, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390763.

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Mohrmann, Inga [Verfasser]. "Array-CGH bei Patienten mit Intelligenzminderung / Inga Mohrmann". Lübeck : Zentrale Hochschulbibliothek Lübeck, 2014. http://d-nb.info/1046429280/34.

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Lee, Sansan. "Genetic counseling perspectives on prenatal array CGH testing". Waltham, Mass. : Brandeis University, 2009. http://dcoll.brandeis.edu/handle/10192/23259.

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Gamero, Angel Mauricio Castro. "Desequilíbrios cromossômicos em nove casos de osteossarcoma detectados através de hibridação genômica comparativa (CGH)". Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-22042013-095920/.

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O osteossarcoma (OS) é o tumor ósseo maligno mais freqüente da infância e adolescência com uma taxa de sobrevida livre de eventos de 50 70% após 3 anos.. O pico de incidência ocorre na segunda década da vida, característica que sugere uma relação entre o rápido crescimento ósseo da adolescência e o desenvolvimento da neoplasia. Ainda, o conhecimento das bases genéticas é insuficiente. Estudos de citogenética clássica têm demonstrado que o OS caracteriza-se por exibir alta heterogeneidade cariotípica, incluindo altos graus de aneuploidia e rearranjos estruturais complexos. A técnica de CGH constitui uma ferramenta valiosa na analise do perfil genômico de tumores sólidos, e tem confirmado a complexidade das alterações cariotípicas em OS, descrita pela citogenética convencional. Não obstante, os estudos existentes são divergentes, e poucos têm estudado as informações obtidas por CGH em relação com a progressão tumoral. O objetivo do presente estudo foi identificar a presença de desequilíbrios cromossômicos em amostras de OS por meio da técnica de CGH. Os experimentos de CGH foram realizados de acordo com o descrito por Kallioniemi et al (1994). Foram analisadas nove amostras (3 biópsias, 5 ixressecções após quimioterapia e 1 metástase). O CGH detectou desequilíbrios cromossômicos em todas as amostras. Os ganhos foram mais freqüentes que as perdas. Muitas alterações cromossômicas foram observadas, especialmente ganhos nos cromossomos 1q, 2, 3p, 4, 5p, 6, 7, 8, 11p, 14q, 16, 21q e X; e perdas nos cromossomos 1p, 2q, 3q, 5q, 9q, 11q e 17q. As regiões mínimas de sobreposição mais freqüentes foram ganhos de 2p13-p14, 2q36-q37, 4q21 e 8p22, e perdas de 1p34.2, 3q22-q23 e 3q24. Três pacientes apresentaram amostras pareadas, e as alterações cromossômicas detectadas foram muito variadas, refletindo a heterogeneidade cromossômica intratumoral em cada caso. A mais alta divergência clonal entre as amostras pareadas foi observada entre a amostra de ressecção e a amostra metastática correspondente, mostrando a complexidade cromossômica adquirida durante a progressão e metastatização no caso descrito. Ainda são necessárias investigações adicionais, que contribuíam para a caracterização completa dos genes localizados nessas regiões.
Osteosarcoma (OS) is the most frequent aggressive bone malignancy affecting children and young adults with an event-free survival of 50-70% after 3 years. The incidence peak occurs during the second decade of life, suggesting a relationship between rapid bone growth and the development of this tumor. The knowledge of the genetic basis behind tumor progression is still limited. Conventional cytogenetic studies have demonstrated that OS exhibits high cariotipic heterogeneity, with different degrees of aneuploidy and complex structural rearrangements. The CGH is an important tool for studying the genomic profiles of solid tumors, and has confirmed the complexity of cariotipic alterations in OS. However, previous studies have shown divergent results and few have correlated them with tumor progression. The objective of present study was to identify chromosome unbalances in nine samples of OS by CGH. 3 biopsies, 5 resections before quimioterapy and 1 metastasis were analyzed. The experiments were performed accordingly with Kallioniemi et al (1994). CGH detected chromosomal imbalances in all samples. Gains were more frequent than losses. Many chromosomal alterations were observed, especially gains at 1q, xi2, 3p, 4, 5p, 6, 7, 8, 11p, 14q, 16, 21q and X; and losses at 1p, 2q, 3q, 5q, 9q, 11q and 17q. The minimal regions of superposition were gains of 2p13-p14, 2q36-q37, 4q21 and 8p22, and losses of 1p43.2, 3q22-q23 and 3q24. Three patients had consecutive samples, and the chromosomal alterations varied, reflecting the chromosomal heterogeneity for each case. The highest clonal divergence among the consecutive samples was observed between resection and the corresponding metastatic sample, showing the chromosomal complexity acquired during the progression and dissemination in this case. Additional investigations for the characterization of genes at these regions are necessary.
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Herr, Alexander [Verfasser]. "Hochauflösende CGH mit Hilfe von DNS-Mikrorastern / Alexander Herr". Berlin : Freie Universität Berlin, 2005. http://d-nb.info/1021667471/34.

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Marioni, John Carlo. "Statistical methods for array CGH and copy number variation experiments". Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611877.

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Książki na temat "CGH"

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Palabra de CGH: El testimonio de los huelguistas. [México]: Ediciones del Milenio, 2000.

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Kim, Ho-jung. array-CGH rŭl iyong han piso sepʻo pʻyeam ŭi chogi chaebal pʻyojija mit chindan mohyŏng kaebal =: Development of early-recurrence detection marker and diagnostic model using array-CGH in NSCLC. [Seoul]: Pogŏn Pokchibu, 2007.

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Arnold, David B., i Peter R. Bono. CGM and CGI. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-61378-4.

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Alheit, Bernd, Martin Göbel, Max Mehl i Rolf Ziegler. CGI und CGM. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-662-06229-6.

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McKay, Lucia. CGI/CGM primer. Austin, TX, USA (1515 Capital of Texas Highway S., Suite 300, Austin 78746): Nova Graphics International Corp., 1987.

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B, Alheit, red. CGI und CGM: Graphische Standards für die Praxis. Berlin: Springer, 1991.

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1945-, Bono Peter R., red. CGM and CGI: Metafile and interface standards for computer graphics. Berlin: Springer-Verlag, 1988.

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Ed, Tittel, red. CGI bible. Foster City, CA: IDG Books Worldwide, 1996.

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CGI/Perl. Boston: Course Technology, 2002.

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Perpar-Prokić, Nada. Ceh: Roman. Beograd: Žagor, 2009.

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Części książek na temat "CGH"

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Liehr, Thomas, Anita Glaser i Nadezda Kosyakova. "Comparative Genomic Hybridization (CGH) and Microdissection-Based CGH (Micro-CGH)". W Springer Protocols Handbooks, 561–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-52959-1_54.

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Arnemann, J. "Array-CGH". W Springer Reference Medizin, 206–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_3439.

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Calistri, Daniele. "Array CGH". W Encyclopedia of Cancer, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_401-2.

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Arnemann, J. "Array-CGH". W Lexikon der Medizinischen Laboratoriumsdiagnostik, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-49054-9_3439-1.

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Dimitriadou, Eftychia, i Joris R. Vermeesch. "Array CGH". W Springer Protocols Handbooks, 567–86. Berlin, Heidelberg: Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-52959-1_55.

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Calistri, Daniele. "Array CGH". W Encyclopedia of Cancer, 362–64. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-46875-3_401.

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Henn, Traudl, i Oskar A. Haas. "Comparative Genomic Hybridisation (CGH)". W Diagnostic Cytogenetics, 376–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1999. http://dx.doi.org/10.1007/978-3-642-59918-7_21.

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Kothmaier, Hannelore, Elvira Stacher, Iris Halbwedl i Helmut H. Popper. "Comparative Genomic Hybridisation (CGH)". W Guidelines for Molecular Analysis in Archive Tissues, 203–14. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-17890-0_32.

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Schwaenena, Carsten, Michelle Nesslinga, Bernhard Radlwimmera, Swen Wessendorf i Peter Lichtera. "Applications of Matrix-CGH (Array-CGH) for Genomic Research and Clinical Diagnostics". W Biological and Medical Physics, Biomedical Engineering, 251–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/3-540-26578-3_12.

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Matsushima, Kyoji. "Fabrication of High-Definition CGH". W Series in Display Science and Technology, 395–441. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-38435-7_15.

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Streszczenia konferencji na temat "CGH"

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Wang, Min, i Simon Thibault. "CGH null design and fabrication for CFH telescope simulator". W Optical Systems Design, redaktorzy Roland Geyl, David Rimmer i Lingli Wang. SPIE, 2004. http://dx.doi.org/10.1117/12.513382.

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Morris, James E., i Michael R. Feldman. "Dynamic optical interconnect systems". W OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1991. http://dx.doi.org/10.1364/oam.1991.tuff7.

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Dynamic optical interconnect systems are being investigated. These systems consist of fixed, high frequency, computer-generated holograms (CGHs) and dynamic spatial light modulators (SLMs). The CGH is used to achieve a high space-bandwidth product that is currently not available in SLMs and the SLMs provide the dynamic properties. Each modulator changes the wavefront that hits a large area of CGH. The CGH is designed so that different wavefronts will send light to different positions. This method allows for local control (modulators in same plane as processors) or external control (modulators in different plane than processors) of the connections. Computer simulations have been preformed on various system configurations to test this theory. Iterative optimization techniques are used to design the CGHs and take into account quantizations in the CGHs and SLMs.
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Lohmann, Adolf W., i Stefan Sinzinger. "Improvements of the graphic code of computer generated holograms". W OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1991. http://dx.doi.org/10.1364/oam.1991.turr4.

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During recent years, research in the area of computer generated holography (CGH) almost exclusively dealt with the improvement of the algorithms to produce CGHs with enhanced performance. Now we would like to concentrate on improvements of the CGH quality by using certain tricks during the actual manufacturing process. In most CGHs the sampling cells contain one or sometimes two black rectangles. The size of the rectangle is responsible for the local light amplitude. The location of the rectangle determines the phase of the light, which is diffracted at that cell.
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Nakkar, Mouna, Jared Stack, W. Hudson Welch i Michael R. Feldman. "Computer generated holograms for large deflection angle optical interconnects". W OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1992. http://dx.doi.org/10.1364/oam.1992.fp4.

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Although many papers have recently been published on computer generated holograms (CGHs) or diffractive optics for optical interconnects, most research has concentrated on connections that involve relatively small angles. Small angle connections require relatively low CGH spatial frequencies and can be implemented efficiently with many CGH design and encoding methods. Large angle connections, however, are needed to implement long distance interconnects with a high connection density. For example, an optically interconnected multichip module system is currently under development. Connection lengths of up to 40 mm and angles as large as 27° are needed. For such large deflection angles, the CGH spatial frequencies are so large that with conventional encoding methods only two phase levels can be employed, and the resulting diffraction efficiency through two successive holograms is limited to a maximum value of 16%. Therefore we developed a new encoding method that allowed us to increase the number of phase levels in the CGH, thereby increasing the diffraction efficiency.
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Burmeister, Frank, Sascha Ehrhardt, Tino Benkenstein, Tom Lammers, Antonia Klein, Philipp Schleicher, Thomas Flügel-Paul i in. "CGH for ESO’s ELT M2 reference plate: fabrication of high precision CGHs". W Advances in Optical and Mechanical Technologies for Telescopes and Instrumentation IV, redaktorzy Roland Geyl i Ramón Navarro. SPIE, 2020. http://dx.doi.org/10.1117/12.2562827.

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Cederquist, J. N., J. R. Fienup i A. M. Tai. "Cgh Fabrication Techniques And Facilities". W 1988 Los Angeles Symposium--O-E/LASE '88, redaktor Sing H. Lee. SPIE, 1988. http://dx.doi.org/10.1117/12.944158.

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Arima, Yasuaki, Kyoji Matsushima i Sumio Nakahara. "Hybrid CGH by Digitized Holography: CGH for Mixed 3D Scene of Virtual and Real Objects". W Digital Holography and Three-Dimensional Imaging. Washington, D.C.: OSA, 2011. http://dx.doi.org/10.1364/dh.2011.dwc28.

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Ikeda, Sukai, i Kyoji Matsushima. "Holographic 3D Portrait Created by Full-Parallax High-Definition Computer Holography and 3D Face Reconstruction". W Digital Holography and Three-Dimensional Imaging. Washington, D.C.: Optica Publishing Group, 2022. http://dx.doi.org/10.1364/dh.2022.w2a.1.

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A technique using the 3D Face Reconstruction technology is proposed to create 3D portrait CGHs from a single 2D portrait image. An actual full-parallax portrait CGH is demonstrated to verify the technique.
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"ROBUSTNESS OF EXON CGH ARRAY DESIGNS". W International Conference on Bioinformatics Models, Methods and Algorithms. SciTePress - Science and and Technology Publications, 2011. http://dx.doi.org/10.5220/0003153201730182.

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Kley, Ernst-Bernhard, Werner Rockstroh, Holger Schmidt, Andreas Drauschke, Frank Wyrowski i Lars-Christian Wittig. "Investigation of large null-CGH realization". W International Symposium on Optical Science and Technology, redaktorzy Ernst-Bernhard Kley i Hans Peter Herzig. SPIE, 2001. http://dx.doi.org/10.1117/12.448033.

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Raporty organizacyjne na temat "CGH"

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Cavalli, Luciane R. Detection of Genetic Alterations in Breast Sentinel Lymph Node by Array-CGH. Fort Belvoir, VA: Defense Technical Information Center, październik 2005. http://dx.doi.org/10.21236/ada444833.

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Cavalli, Luciane R. Detection of Genetic Alterations in Breast Sentinel Lymph Node by Array-CGH. Fort Belvoir, VA: Defense Technical Information Center, październik 2006. http://dx.doi.org/10.21236/ada460808.

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Seroussi, Eyal, i George Liu. Genome-Wide Association Study of Copy Number Variation and QTL for Economic Traits in Holstein Cattle. United States Department of Agriculture, wrzesień 2010. http://dx.doi.org/10.32747/2010.7593397.bard.

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Copy number variation (CNV) has been recently identified in human and other mammalian genomes and increasing awareness that CNV might be a major source for heritable variation in complex traits has emerged. Despite this, little has been published on CNVs in Holsteins. In order to fill this knowledge-gap, we proposed a genome-wide association study between quantitative trait loci (QTL) for economic traits and CNV in the Holstein cattle. The approved feasibility study was aimed at the genome-wide characterization of CNVs in Holstein cattle and at the demonstrating of their possible association with economic traits by performing the activities of preparation of DNA samples, Comparative Genomic Hybridization (CGH), initial association study between CNVs and production traits and characterization of CNVSNP associations. For both countries, 40 genomic DNA samples of bulls representing the extreme sub-populations for economically important traits were CGH analyzed using the same reference genome on a NimbleGen tiling array. We designed this array based on the latest build of the bovine genome (UMD3) with average probe spacing of 1150 bases (total number of probes was 2,166,672). Two CNV gene clusters, PLA2G2D on BTA2 and KIAA1683 on BTA7 revealed significant association with milk percentage and cow fertility, respectively, and were chosen for further characterization and verification in a larger sample using other methodologies including sequencing, tag SNPs and real time PCR (qPCR). Comparison between these four methods indicated that there is under estimation of the number of CNV loci in Holstein cattle and their complexity. The variation in sequence between different copies seemed to affect their functionality and thus the hybridization based methods were less informative than the methods that are based on sequencing. We thus conclude that large scale sequencing effort complemented by array CGH should be considered to better detect and characterize CNVs in order to effectively employ them in marker-assisted selection.
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Godwin, Andrew K. Identification of Candidate Breast Cancer Susceptibility Genes Using a cDNA Microarray/CGH Approach. Fort Belvoir, VA: Defense Technical Information Center, maj 2002. http://dx.doi.org/10.21236/ada408112.

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Godwin, Andrew K. Identification of Candidate Breast Cancer Susceptibility Genes Using a cDNA Microarray/CGH Approach. Fort Belvoir, VA: Defense Technical Information Center, maj 2003. http://dx.doi.org/10.21236/ada417397.

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Burton, Donald, Nathaniel Morgan, Theodore Carney i Mark Kenamond. Reduction of dissipation in Lagrange cell-centered hydrodynamics (CCH) through corner gradient reconstruction (CGR). Office of Scientific and Technical Information (OSTI), styczeń 2015. http://dx.doi.org/10.2172/1164015.

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Mudge, Christopher, i Michael Netherland. Evaluation of new endothall and florpyrauxifen-benzyl use patterns for controlling crested floating heart and giant salvinia. Engineer Research and Development Center (U.S.), listopad 2020. http://dx.doi.org/10.21079/11681/38859.

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The purpose of this research was to (1) evaluate concentration exposure time (CET) relationships for florpyrauxifen-benzyl (ProcellaCOR) for control of the floating leaved plant crested floating heart (Nymphoides cristata, CFH) and (2) evaluate foliar applications of endothall (Aquathol K) for control of CFH and the floating fern giant salvinia (Salvinia molesta).
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Schoen, Robert C., Wendy S. Bray, Amanda M. Tazaz i Charity K. Buntin. A Description of the Cognitively Guided Instruction Professional Development Program in Florida: 2013–2020. Florida State University Libraries, luty 2022. http://dx.doi.org/10.33009/fsu.1643828800.

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Cognitively Guided Instruction (CGI) is a teacher PD program that has been found to have a potentially positive impact on student learning in mathematics through randomized controlled trials. Through a series of grant-funded projects led by FSU, approximately 2,000 Florida teachers have participated in CGI-based professional development in the past 8 years. This paper describes the core features of the CGI-based PD programs that were implemented in Florida during that time period. We provide this information to help researchers and practitioners to understand the context in which the associated research studies occurred and interpret the available and forthcoming findings related to the impacts of the interventions.
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Семеріков, Сергій Олексійович, i Ілля Олександрович Теплицький. Побудова найпростішої системи тестового контролю знань на основі Web-технологій. НПУ імені М. П. Драгоманова, 2004. http://dx.doi.org/10.31812/0564/799.

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Filippo, Agustín, i Carlos Guaipatín. Modelo de intervención en las cadenas globales de valor de las industrias pesadas y otros sectores estratégicos en México. Inter-American Development Bank, sierpień 2021. http://dx.doi.org/10.18235/0003756.

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El nuevo entorno económico global en el que se inserta México, marcado fundamentalmente por el impacto del COVID-19 en una potencial relocalización de las Cadenas Globales de Valor (CGV), la entrada en vigor del T-MEC desde mediados de 2020 y la continuidad de las tensiones comerciales entre Estados Unidos y China, plantea nuevos desafíos y oportunidades para el fortalecimiento de la inserción de México en las CGV que resultan relevantes de identificar como un primer insumo para la política pública. A partir de esos antecedentes, el principal objetivo de este trabajo es analizar cómo México puede aprovechar las oportunidades que se abren ante las nuevas condiciones del entorno global, a través de la identificación de sectores estratégicos, bienes y procesos con potencial de desarrollo de proveeduría local, tal que permitan aumentar la participación del país en las CGV.
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