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Rozprawy doktorskie na temat „Cellular Delivery - Anionic Nanoparticles”

Autor: Grafiati

Data publikacji: 7 września 2023

Data aktualizacji: 31 lipca 2025

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1

Zhang, Mengzi. "DEVELOPMENTS OF LIPID-BASED NANOPARTICLES FOR THERAPEUTIC DRUG DELIVERY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417025932.

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2

Mendez, Eladio A. "Conjugated Polymer Nanoparticles for Biological Labeling and Delivery." FIU Digital Commons, 2015. http://digitalcommons.fiu.edu/etd/1837.

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Cancer remains one of the world’s most devastating diseases, with more than 10 million new cases every year. However, traditional treatments have proven insufficient for successful medical management of cancer due to the chemotherapeutics’ difficulty in achieving therapeutic concentrations at the target site, non-specific cytotoxicity to normal tissues, and limited systemic circulation lifetime. Although, a concerted effort has been placed in developing and successfully employing nanoparticle(NP)-based drug delivery vehicles successfully mitigate the physiochemical and pharmacological limitati

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3

Khan, Md Arif. "NANOHARVESTING AND DELIVERY OF BIOACTIVE MATERIALS USING ENGINEERED SILICA NANOPARTICLES." UKnowledge, 2019. https://uknowledge.uky.edu/cme_etds/110.

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Mesoporous silica nanoparticles (MSNPs) possess large surface areas and ample pore space that can be readily modified with specific functional groups for targeted binding of bioactive materials to be transported through cellular barriers. Engineered silica nanoparticles (ESNP) have been used extensively to deliver bio-active materials to target intracellular sites, including as non-viral vectors for nucleic acid (DNA/RNA) delivery such as for siRNA induced interference. The reverse process guided by the same principles is called “nanoharvesting”, where valuable biomolecules are carried out and

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4

Duong, Anthony David. "Electrohydrodynamic Spray Fabrication of Microparticles and Nanoparticles for Use as Biomedical Delivery Vehicles." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1376913508.

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5

Li, Miao [Verfasser], and Jochen [Akademischer Betreuer] Feldmann. "Optical cellular delivery and intracellular sensing of fN forces using gold nanoparticles / Miao Li. Betreuer: Jochen Feldmann." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1110748965/34.

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6

Graf, Franziska. "DNA Origami Nanoparticles for Cell Delivery: The Effect of Shape and Surface Functionalization on Cell Internalization." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10259.

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An outstanding challenge in modern medicine is the safe and efficient delivery of drugs. One approach to improve drug delivery yield and increase specificity towards diseased cells, is to employ a drug carrier to facilitate transport. Promising steps towards developing such a carrier have been taken by the nascent field of nanomedicine: nanometer-sized particles designed to evade premature excretion, non-specific absorption, and the body’s immune response, can reduce undesired drug loss, while also increasing specific drug uptake into diseased cells through targeting surface modifications. How

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7

Nitin, Nitin. "Optical and MR Molecular Imaging Probes and Peptide-based Cellular Delivery for RNA Detection in Living Cells." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-08102005-120350/.

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Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2006.<br>Dr. X. Hu, Committee Member ; Dr. Al Merrill, Committee Member ; Dr. Niren Murthy, Committee Member ; Dr. Gang Bao, Committee Chair ; Dr. Nicholas Hud, Committee Member. Includes bibliographical references.

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8

Huang, Xiaomeng. "Targeted Delivery of MicroRNAs by Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405095496.

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9

Liebsch, Nicole Verfasser], and Claus-Michael [Akademischer Betreuer] [Lehr. "Cationic polymer coating of PLGA nanoparticles for enabling cellular delivery of siRNA / Nicole Liebsch ; Betreuer: Claus-Michael Lehr." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:291-scidok-ds-271196.

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10

Liebsch, Nicole [Verfasser], and Claus-Michael [Akademischer Betreuer] Lehr. "Cationic polymer coating of PLGA nanoparticles for enabling cellular delivery of siRNA / Nicole Liebsch ; Betreuer: Claus-Michael Lehr." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2017. http://d-nb.info/1155760522/34.

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11

Sun, Bingyun. "Spatially and temporally resolved delivery of stimuli to single cells using nanocapsules and laser manipulation /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/8544.

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12

PERIN, ELENA. "Passive drug targeting and delivery of antitumor Pt(IV) prodrugs." Doctoral thesis, Università del Piemonte Orientale, 2017. http://hdl.handle.net/11579/86923.

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Cisplatin and its analogues are important drugs for the treatment of many malignant tumors, but many side effects and deactivation processes may occur. In order to overcome these limits, the Pt(IV) complexes higher inertness can be exploited. They are activated to their corresponding Pt(II) active metabolite only in the tumor site, taking advantage of the hypoxic and reducing milieu of neoplastic cells: for this reason, they are considered prodrugs. Furthermore, passive Drug Targeting and Delivery (DTD) strategies can be developed to improve the selective accumulation of such species. The tumo

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13

Johnston, Alyssa N. "A Ternary Drug Delivery Complex to Target CD44 Over Expressing Cancerous Cell Lines." Kent State University Honors College / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1335737666.

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14

Manandhar, Prakash. "Understanding the Functional Group-dependent Self-assembly and Cellular Entry of Cationic Conjugated Polymer Nanoparticles." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3673.

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Highly fluorescent conjugated polymers (CPs) are an important class of biomaterials used for various biological applications including labelling, sensing, and delivery of biological substances. Synthetic versatility and tunable emission make CPs a superior class of biomaterials. Understanding the structure-function relationship of CPs plays a vital role in designing high performing biomaterials. The cationic CPs are self-assembled to conjugated polymer nanoparticles (CPNs) in an aqueous environment due to their amphiphilicity. The physical and biophysical properties of CPNs are highly dependen

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15

Shokouhimehr, Mohammadreza. "Prussian Blue Nanoparticles and its Analogues as New-Generation T1-Weighted MRI Contrast Agents for Cellular Imaging." Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1275612500.

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16

Sauer, Anna Magdalena [Verfasser], and CHRISTOPH [Akademischer Betreuer] BRAEUCHLE. "Live-cell imaging of drug delivery by mesoporous silica nanoparticles : Drug loading, pore sealing, cellular uptake and controlled drug release / Anna Magdalena Sauer. Betreuer: Christoph Bräuchle." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1018847219/34.

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17

Ribeiro, Caroline Arana da Silva. "Influência de parâmetros estruturais sobre a eficiência de encapsulação, perfil de liberação e captura celular de nanopartículas poliméricas biodegradáveis." reponame:Repositório Institucional da UFABC, 2017.

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Orientador: Prof. Dr. Fernando Carlos Giacomelli<br>Dissertação (mestrado) - Universidade Federal do ABC, Programa de Pós-Graduação em Biotecnociência, 2017.<br>O uso de nanopartículas poliméricas vem progressivamente se intensificando nos últimos anos, principalmente em que pese a aplicações na área biomédica. Neste cenário, o foco principal reside na utilização de polímeros biodegradáveis para fabricação de sistemas nanocarregadores de agentes ativos. Particularmente no campo da nanomedicina, a habilidade de se controlar a dimensão de nanopartículas, bem como se entender o perfil de liberaçã

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18

Casajus, Hubert. "Étude de la polymérisation enzymatique de la malolactonates en présence de lipases." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1S090/document.

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Les polyesters aliphatiques, comme le poly(acide malique) et ses dérivés, sont une famille de polymères aux propriétés de bio(comptabilité) et de bio(dégradabilité) remarquables, qui en font des candidats de choix pour l'élaboration de systèmes de vectorisation de principes actifs. Généralement, ces polymères sont synthétisés via des réactions de polymérisation utilisant des amorceurs, voir des catalyseurs, organiques, organométalliques ou métalliques. La présence de ces molécules, même à l'état de traces, peut être à l'origine d'une toxicité non souhaitée. Par conséquent, l'utilisation de bio

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19

Maity, Amit Ranjan. "Functionalised nanoparticle and quantum dot as cellular imaging probe." Thesis, 2019. http://hdl.handle.net/10821/8298.

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Preface One of the fundamental goals in biology is to understand the complex spatiotemporal interplay of biomolecules from the molecular to the integrative level. To study these interactions, researchers commonly use imaging tool both in in-vitro and invivo under different imaging modalities. Conventionally used fluorescent based molecular probes have several potential limitations, such as lower brightness, photo bleaching problem and broad absorption/emission spectra. In contrast nanoparticles based imaging probes have advantages as they have high molar extinction coefficients, high resistanc

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20

Shrestha, Ritu 1984. "Multi-functional Bio-synthetic Hybrid Nanostructures for Enhanced Cellular Uptake, Endosomal Escape and Targeted Delivery Toward Diagnostics and Therapeutics." Thesis, 2012. http://hdl.handle.net/1969.1/148332.

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Applications of nanotechnology in medicine, also known as nanomedicine, is a rapidly growing field as it holds great potential in the development of novel therapeutics toward treatment of various diseases. Shell crosslinked knedel-like nanoparticles (SCKs) that are self assembled from amphiphilic block copolymers into polymeric micelles followed by crosslinking selectively throughout the shell domain have been investigated as theranostic agents for the delivery of nucleic acids and incorporation of imaging probes. The main focus of this dissertation is to design and develop unique multifunct

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21

Rebanda, Magda Mora. "Poly : l-lactide-co-caprolactone-co-glycolide : based nanocarriers for drug delivery : synthesis optimization and cellular studies." Master's thesis, 2018. http://hdl.handle.net/10400.14/30648.

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Nanomedicine has viewed countless breakthroughs in drug implementation. Nanomaterials have been used to enable enhanced drug delivery to tumor cells with lower toxicity to healthy ones. Controlled Drug Delivery Systems (DDS) have several advantages compared to the traditional forms of drugs. Indeed, when a drug is transported efficiently to the place of action its influence on vital tissues and undesirable side effects can be significantly minimized. Its accumulation at the target site increases and, consequently, the required doses are lower. Different nanoparticles (NPs) have been developed

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22

Ghotbi, Zahra. "PLGA-based nanoparticles for targeting of dendritic cells in cancer immunotherapy and immunomonitoring." Master's thesis, 2010. http://hdl.handle.net/10048/1016.

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Thesis (M.Sc.)--University of Alberta, 2010.<br>A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science in Pharmaceutical Sciences. Title from pdf file main screen (viewed on February 17, 2010). Includes bibliographical references.

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