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Le, Fessant Elouan. "Etude expérimentale de la revaporisation de dépôt de produits de fission en cas d'accident grave". Electronic Thesis or Diss., Université de Lille (2022-....), 2023. https://pepite-depot.univ-lille.fr/ToutIDP/EDSMRE/2023/2023ULILR011.pdf.
In order to improve the prediction of possible delayed radioactive releases during a SA of a PWR, remobilization phenomena of Fission Product (FP) deposited in the Reactor Cooling System (RCS) have been investigated. These phenomena induce a modification of the FP state to gaseous species or aerosols suspended in the gas flow contributing to these delayed releases. This work, within the OECD ESTER project, is focusing on the revaporization of Cs and I as main contributors to radiological consequences. In addition, tellurium (Te) which may be a source of I by radioactive decay is also studied. To do so, two complementary methodologies are used:- Revaporization experiments aim at assessing the revaporization rate of each studied element, at identifying the revaporized species, and finally at characterizing the remaining solid species.- Thermodynamic simulations aim at defining the main revaporization reactions and the airborne species.Different simulants for FP deposits in the RCS were considered: CsI, CsOH, CdI2, H2TeO4 TeO2. Thanks to the ATMIRE experimental setup covering a large range of temperatures (from 200 to 600 °C), a large range of air partial pressures (from 4.5.10-4 to 0.5 atm) complemented by steam boron vapors in the carrier gas, revaporization behaviors of Cs, I, Cd and Te were characterized. The samples were characterized thanks to combined chemical and surface analyses such as ICP-MS, XPS, and ToF-SIMS. Thanks to these techniques, identification and quantification of both gaseous and solid species formed throughout the tests were possible. Then experimental results were compared to thermodynamic calculations to confirm the main revaporization paths of each FP simulant.Above 400 °C, the CsI revaporization result in both CsI vaporization and decomposition under an air/steam atmosphere. CsI decomposition leads to the formation of gaseous iodine (HOI, I, or I2) and Cs species such as CsOH and CsNO3 as well as Cs2CrO4 (due to Cs interaction with oxidized SS) or CsBO2 (by interaction with boron in the revaporization atmosphere).Under steam/air atmosphere, CdI2 is totally decomposed above 200 °C leading to the formation of gaseous I (mainly I2) and Cd (such as CdO or Cd(OH)2).Finally, at high temperatures (above 400 °C), H2TeO4 is reduced and dehydrated to form TeO2 whatever the proportion of air (from 4.5.10-4 atm to 1 atm). For TeO2, revaporization is not influenced by Pair but is strongly increased in presence of CsOH with the formation of Cs-Te-O species (such as Cs2TeO3 or Cs2TeO4)
Guimarães, Tathiane Barbosa. "Perfil psicossocial de portadores de CDI: COMFORT-CDI". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-24102016-154635/.
Introduction: Anxiety, depression, Type D personality, and implantable cardioverter-defibrillator (ICD) shocks are well-known risk factors for psychosocial maladjustment. Despite the fact that most of the studies were conducted in well-developed countries, little attention has been given to these and others factors and their influence on ICD patients\' perceptions of their heart disease. Coping strategies, the differences between ICD patient and heart disease patient perceptions, and the perception of family members has also been neglected. This project was aimed at describing the psychosocial profile of Brazilian ICD patients and evaluating the relationship between the aforementioned risk factors and patient perceptions about their heart disease and ICD, the temporal relation between occurrence and frequency of ICD shocks, and the understanding and perception of family members regarding the ICD. Methods: 250 ICD patients were evaluated (54.10 ±15.15 years, 67% male) regarding illness perception (Brief Illness Perception Questionnaire [B-IPQ]); anxiety, depression, distress (Hospital Anxiety and Depression Scale [HADS]); Type D personality (DS-14); occurrence and frequency of ICD shocks since implantation; and coping. Family members\' comprehension and emotional representations of the ICD were also assessed. Mann-Whitney, Wilcoxon and X2 were used for statistical analysis. Results: Ninety-nine patients (40%) had anxiety, 62 (25%) depression; 85 (34%) distress, 84 (34%) Type D personality, and 72 (29%) perceived the heart disease as a threat. Anxiety, distress, depression, and Type D personality were associated with perceiving heart disease as a health threat with odds ratios of 11 (p= <.0001); 7.4 (p= <.0001); 5.3 (p= <.0001); and 2.9 (p= 0.0001), respectively. Patients\' perceptions of their heart disease as a threat were also influenced by ICD shocks since implantation with odds ratios of 2.1 (p= 0.007), of 2.1 for >=3 shocks in 24 hours (p= 0.045) and of 2.4 for >= 5 shocks since implantation (p= 0.043). Anxious and Type D patients were also associated with poorer illness perceptions regarding: 1 - strong beliefs about more serious consequences of the illness; 2 - not being capable of controlling the disease on their own; 3 - a greater number of symptoms attributed to the illness; 4 - more concerns and negative reactions. Distressed or depressive patients\' perceptions are more negative on every item of the scale except for understanding. The majority of patients (68%) used emotion focused coping mechanisms. Twenty-five percent of the patients reported feeling limited by heart disease, while 75% reported feeling limited by having the ICD in place. Patients perceived more negative consequences with heart disease than with ICD placement. Family members manifested distress about the ICD and misunderstanding regarding its purpose and function. Conclusions: ICD patients treated in a tertiary heart center presented with incresead frequency of anxiety, depression, distress, Type D personality, and perception of their illness as threat. Limitation of activities of daily living was the most common complaint. Heart disease was reported as more debilitating than the ICD itself, but most patients still considered the device\'s shock aversive. Implication: Specific psychosocial interventions are essential for better adjustment of ICD patients and their families after ICD placement
Burman, Per. "Extending CDIF to support Enterprise Modeling". Thesis, University of Skövde, Department of Computer Science, 1997. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-287.
In recent years organizations developing information systems have started to demand that there should be an explicit connection between the rationale of the system developed and the system itself. In the "From Fuzzy to Formal" project an attempt to develop a methodology supporting this was made. Within the project a method called Enterprise Modeling was developed, aiming at creating this connection. This method contains five different sub-models. The sub-models are connected to each other by inter-model links. The models developed using EM are of high complexity. Therefore tool and repository support should be provided. To be flexible and extendible, such a tool set should be based upon a standardized meta-model. CDIF is an example of such a standard.
In this dissertation we develop a meta-model capable of capturing the information that is created using the Enterprise Modeling technique. We use the extensibility mechanism that is provided with the CDIF standard to extend the existing CDIF Integrated meta-model to support the models used in this work. We also develop a procedure supporting the mapping between the representations. Finally we discuss the functionality of a tool capable of supporting the work with the models.
Duncan, Tod. "Identifying substrates of CDK2:cyclin A". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396250.
Walker, Jennifer Anne. "CD22, autoimmunity and the B cell". Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612192.
Feliciano, Lisa. "Clostridium difficile Infection (CDI): Use of Preventive Bundle to Decrease CDI Incidences". ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5188.
Lam, Jennifer. "Dll1 is a Potential CDX2 Target Gene". Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28896.
Harris, Ruth V. "Phosphorylation of linker histones by cdc2 kinase". Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336626.
Colleypriest, Benjamin John. "The role of Cdx2 in Barrett's metaplasia". Thesis, University of Bath, 2010. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.524136.
LEBEL-BINAY, SOPHIE. "Caracterisation fonctionnelle d'une nouvelle proteine transmembranaire : cd82". Paris 7, 1995. http://www.theses.fr/1995PA077277.
Palmquist, Kristian. "Extending CDIF to support Business Rules targeting SQL3". Thesis, University of Skövde, Department of Computer Science, 1997. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-298.
Business Rules have gained attention in recent years and are now considered to be important organizational elements. Several sources in the literature argue that there are major achievements to be made with an explicit business rule focus in software engineering, e.g. promoting communication between analysts and users and accounting for changeability and maintenance aspects. However, to fully take advantage of an explicit rule focus in software engineering requires the ability to create business rule models. The problem is that business rule models of realistic size quickly become extensive and complex, hence there is a need for CASE tool support.
We choose a modeling technique from the literature which is suited to express business rules. Basec on this modeling technique we propose an extension to the Case Data Interchange Format standard (CDIF), thereby allowing the standard to express and support the transfer of business rule models. In addition, we define a mapping procedure that which maps business rules from the conceptual modeling level via CDIF (using the proposed extensions) to SQL3 triggers. The main idea is that the mapping algorithms could be used by a CDIF conformant CASE tool which allows traditional database design, together with extended modeling constructs for expressign business rules.
Meschini, Elisa. "Purine-based dual inhibitors of CDK2 and CDK7". Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1363.
Glasssmith, Gareth. "Characterisation of cdc2-related kinases from Trypanosoma brucei". Thesis, University of Glasgow, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363169.
Ko, Tun Kiat. "Characterization of Crk7-a novel Cdc2-related kinase". Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621784.
LAGAUDRIERE, GESBERT CECILE. "Caracterisation biochimique et fonctionnelle de la tetraspanine cd82". Paris 11, 1997. http://www.theses.fr/1997PA112138.
Strömsten, Eva-Lotta. "CDIO-modellen som stöd för teknikundervisning på gymnasiet". Thesis, Luleå tekniska universitet, Pedagogik, språk och Ämnesdidaktik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-78905.
Oakes, Vanessa Louise. "Cyclin A/CDK2 regulates multiple G2 phase pathways". Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/63534/1/Vanessa_Oakes_Thesis.pdf.
Wöhner, Miriam [Verfasser], i Lars [Akademischer Betreuer] Nitschke. "Entwicklung einer knockin Mauslinie mit Expression von humanem CD22 zum Test therapeutischer Anwendungen künstlicher CD22-Liganden / Miriam Wöhner. Betreuer: Lars Nitschke". Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1024608700/34.
Greenberg, David. "An analysis of CD2 expression and the use of CD2 sequences for thymus directed oncogenesis". Thesis, University College London (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315354.
Mateo, González Francesca. "Regulació del complex ciclina A-CDK2 per l'acetilasa PCAF". Doctoral thesis, Universitat de Barcelona, 2009. http://hdl.handle.net/10803/914.
En aquest treball presentem un nou mecanisme de regulació dels complexes ciclina-CDK. Concretament hem observat que els membres del complex ciclina A-CDK2 interaccionen amb l'acetilasa PCAF. Aquesta proteïna ha estat generalment considerada com a un co-activador transcripcional gràcies a la seva capacitat d'acetilar histones i activar la transcripció gènica. Tanmateix, també s'ha vist que és capaç d'acetilar proteïnes no-histones com ara p53 o MyoD, i com a conseqüència està implicada en altres funcions cel·lulars com la diferenciació o la resposta a dany al DNA. L'acetilasa PCAF s'uneix al complex ciclina A-CDK2 tot inhibint la seva activitat quinasa. A més, acetila la ciclina A, cosa que comporta la seva degradació pel sistema ubiquitina-proteasoma. PCAF també acetila CDK2 a la lisina 33, la qual es troba molt conservada a la família de les CDKs, ja que és un aminoàcid crucial per a la interacció amb l'ATP. L'acetilació de CDK2 a la lisina 33 comporta la inhibició de la seva activitat quinasa i la seva separació de la ciclina A.
En conclusió, els resultats d'aquesta tesi aporten un nou nivell de regulació dels complexes ciclina-CDK desconegut fins ara, i que cal tenir en compte com a possible mecanisme d'acció dels fàrmacs basats en compostos inhibidors de deacetilases els quals, d'altra banda, estan donant bons resultats en el tractament de malalties hematològiques i tumors sòlids.
"REGULATION OF CYCLIN A-CDK2 COMPLEX BY ACETYLATION"
TEXT:
Cell cycle proteins are regulated in different ways, being phosphorylation one of the most important and more studied mechanisms of regulation. On the other hand, acetylation is another kind of post-translational modification that was discovered in histones and initially it was associated with transcriptionally active chromatin. However, different studies indicate that acetylation can also play a role in the regulation of non-histone proteins and it has been linked to oncogenesis and cardiovascular and neurodegenerative diseases.
In this work we report that cyclin A/cdk2 complex, which is crucial for cell cycle progression during S phase, is acetylated by the acetyltransferase P/CAF. Cyclin A directly interacts with P/CAF and is acetylated at lysines 54, 68, 95 and 112. Maximal acetylation occurs simultaneously to ubiquitylation at mitosis, indicating a role of acetylation on cyclin A stability. A non-acetylatable mutant in which these lysines were substituted by arginines (cycA 4R) cannot be ubiquitylated, is more stable than cycA wild-type and arrests cell cycle at mitosis.
Increased expression of cyclin A has been detected in many types of cancers and it has a prognostic value to predict survival or early relapse. Our results indicate that acetylation is able to cause a decrease in the levels of cyclin A, suggesting that treatment with HDAC inhibitors (which potentiate acetylation in the cell) could be considered to treat this kind of tumors.
Hayles, J. "Suppressor analysis of the cdc2 gene in Schizosaccharomyces pombe". Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377076.
Brown, Marion Hanbury. "Physical interactions of the CD2 antigen". Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277634.
Mongrain, Sébastien. "Caractérisation du mécanisme de régulation de Cdx2 par la MAP kinase p38 et implication de Cdx2 dans la différenciation des cellules épithéliales intestinales". Mémoire, Université de Sherbrooke, 2006. http://savoirs.usherbrooke.ca/handle/11143/3855.
Mongrain, Sébastien. "Caractérisation du mécanisme de régulation de Cdx2 par la MAP kinase p38 et implication de Cdx2 dans la différenciation des cellules épithéliales intestinales". [S.l. : s.n.], 2006.
Nair, Asmaa. "Expression ectopique du gène homéotique Cdx2 dans les pathologies du système digestif". Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ003/document.
The intestine-specific homeotic transcription factor CDX2 is required throughout life for intestinal homeostasis, the maintenance of intestinal identity and has tumor suppressor activity. In Human, ectopic expression of the gene Cdx2 is observed in several digestive organs as in intestinal metaplasia which is considered as pre-cancerous lesion. This work aimed to investigate the pathophysiological consequences and molecular mechanisms of ectopic expression of CDX2. We created and validated a conditional murine model of CDX2 induction in several digestive organs. Ectopic CDX2 causes intestinal metaplasias only in the stomach and the pancreas which do not spontaneously evolve to cancer, depending on cellular context. However, CDX2 promotes intestinal carcinogenesis in complete intestinal metaplasia of the stomach. Collectively, these results show that CDX2 is essential for the development of intestinal metaplasia but has no oncogenic function in ectopic situation
Delhorme, Jean-Baptiste. "Etude des mécanismes de chimiorésistance dans les cancers digestifs : impact de CDX2 et des transporteurs ABC". Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ119.
Chemoresistance represents a major drawback in digestive cancers’ management and may be achieved particularly through active efflux of the drug through overexpression of ABC transporters The transcription factor CDX2 is a master regulator of intestinal identity that acts as a tumor suppressor in the colon and may be important for drug resistance in colorectal cancer (CRC) as MDR1/ABCB1 was recently identified as one of its target genes. Here, we confirmed the role of CDX2 in the chemoresistance of CRC. We showed through a translational approach that CDX2 overexpression is implicated in 5-fluorouracil (5-FU) chemoresistance in CRC and described the molecular mechanisms implicated in this finding. We identified the 5-FU transporter ABCC11 as a new transcriptional target of CDX2 whose activity contributes to the 5-FU-chemoresistance of colon cancer cells. Remarkably, CDX2 expression correlates with the expression of ABCC11 in human colon tumors, but also with the one of the DPYD, enzyme involved in the 5-FU break down. Thus, our study links for the first time CDX2 to the 5-FU metabolism and provides a molecular mechanism for its impact on 5-FU-based chemotherapy
Michet, Florence. "Du CDI physique au CDI numérique : articulation des espaces documentaires réels et de l'offre numérique aux usagers". Thesis, Bordeaux 3, 2020. http://www.theses.fr/2020BOR30016.
This thinking process aims at perceiving the managerial, pedagogical and communication practices introduced by the school librarians in order to create links between the material and the digital school libraries. To the end, we have proceeded with a field survey in the south east of France : 41 school librarians (39 secondary school librarians and 2 high school librarians). Our investigation is organized in two successive periods : an exporatory study followed by a semi-structured interview. The established data has been analysed « step by step », relating the important moments of the participants : those which prove the routine and those which seem unusual. We have compared the words meaning, selecting the reccuring rationales in order to define the conjonctural and particular trends in some schools, leading to a double level. The school librarians appropriate digital tools according to their needs, possibilities and resources in absence of regulatory requirements. They are also constrainted by the school libraries, real documentary spaces they depend on. The current studies are interested in the purely pedagogical or digital aspects but they rarely connect the two facets. Therefore, how may the school librarian, torn between the institutional ordinances and the particular professional necessity, offer a service that could really and efficiently respond to the needs of the users considering its general management ?
Sundareshan, Padma. "Clostridium difficile Infection (CDI) Incidence Rate and CDI-Associated Length of Stay, Total Hospital Charges and Mortality". The University of Arizona, 2009. http://hdl.handle.net/10150/623982.
OBJECTIVES: The purpose of the study was to determine the rate of Clostridium difficile infections (CDI) in hospitalized patients and the various factors that were associated with the risk of developing CDI by examining patient discharge data for hospitals in 37 states in the United States using Healthcare Cost and Utilization Project (HCUP). METHODS: Patient discharge information for all patients obtained using HCUP census for the years 2002-2005, either for primary or secondary (all-listed) occurrences of CDI using the ICD-9-CM code (008.45) specific for intestinal infections due to C. difficile, were included in the study. Regression analysis, either Generalized Linear Model log-link or power-link, or a logistic regression was employed to control for the multiple independent variables. RESULTS: The incidence rate for CDI was 9.4% for the years 2002-2005. Among the concomitant diagnoses and procedures, essential hypertension, volume depletion, congestive heart failure, urinary tract infection and venous catheterization were the top 5. The length of stay (LOS) for CDI was associated with being Black, Hispanic or Other race category, number of diagnoses and procedures, primary expected payer of Medicaid, private insurance and other (including worker’s compensation, CHAMPUS,CHAMPVA etc), and all groups classified based on median household income category for patient’s zip code. Predictors of CDI related to inpatient total hospital charges were being female, race (other than black), number of diagnoses and procedures, Death, LOS, patient location and with self-pay and no charge categories as primary expected payer. Predictors of higher CDI related inpatient hospital deaths were age, female sex, Hispanic race, number of diagnoses and procedures, LOS and having Medicaid, self-pay or other as primary expected payer. CONCLUSIONS: LOS, inpatient total hospital charges, and inpatient mortality were dependent on several patient and other characteristics.
Hecker, Kim Ione. "Bleach-It-Away Clostridium difficile". ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5471.
Balbinot, Camille. "Fonction et mode d'action du gène homéotique intestinal Cdx2 dans les cancers de l'intestin". Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ006/document.
The intestine-specific transcription factor Cdx2 is required throughout life for intestinal homeostasis and for the maintenance of intestinal identity. Several recent studies showed that Cdx2 expression is dramatically reduced in some human colon cancers of poor prognosis. This work aimed to investigate the pathophysiological consequences of the loss of Cdx2 in the adult gut. Conditional mosaic ablation of Cdx2 in mice causes gastric-type metaplasia in the cecum which do not spontaneously evolve to cancer. However, these lesions strongly modify the inflammatory microenvironment which facilitates the malignant transformation of adjacent Cdx2-intact and cancer-prone epithelial cells. Collectively, these results unravel a novel and original function of Cdx2, namely its non-cell autonomous tumor suppressor activity in the gut
Klein, Jörg. "Verwendung von Gene-Targeting-Techniken zur Etablierung neuer Mauslinien mit Mutationen in B-Zell-Signalwegen". [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976107953.
Widström, Stefan. "Teknikämnets utveckling i GY11 : En analys av läromedel och lärares planering av den nya kursen Teknik 1 utifrån kursmålen". Thesis, Uppsala universitet, Institutionen för pedagogik, didaktik och utbildningsstudier, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170617.
Tschannen, Dominique. "Erlebensmodi und Soziale Arbeit : Erläuterungen zu den Erlebensmodi - Überlegungen zur Relevanz für die Soziale Arbeit - handlungstheoretische Folgerungen /". Zürich, 2007. http://www.infostelle.ch/filedownload.html?cdid=3654&file=0.
Schönfeld, Nicole. "Isolation und molekulare Charakterisierung des Apoptose-induzierenden Metastasensuppressors C33/CD82". Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-8675.
今宿, 芳郎. "シロイヌナズナのCDC2遺伝子群の研究". 京都大学 (Kyoto University), 1997. http://hdl.handle.net/2433/202465.
Jean, Bruno. "Propriétés électriques, optiques et électro-optiques du semiconducteur CdIn2 Te4". Bordeaux 1, 1994. http://www.theses.fr/1994BOR10553.
Soffar, Ahmed. "The Role of CDK2 and CDK9 in the Radiation Response of human HNSCC Cancer Cells". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-119407.
Жиляк, Іван Дмитрович. "Акваамінодифосфати Co2+, Ni2+, Cu2+, Zn2+ та Cd2". Rozprawa doktorska kandydata nauk chemicznych, Нац. аграрний ун-т, 2006.
Stell, David Andrew. "Anti-CD2 mediated prolongation of allograft survival". Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340254.
Chen, Ho Ann. "Biophysical characterisation of rat CD2 domain 1". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392332.
Соловйов, М. В., В. А. Франів, О. В. Футей, О. В. Бовгира i А. І. Кашуба. "Динаміка гратки кристалу TI[4]CdI[6]". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45757.
Ravindranath, Priya. "Förmågor utvecklade genom projektarbete inom Teknik1 i förhållande till CDIO : Förmågor och färdigheter som utvecklas i förhållande till CDIO-modellen, genom projektarbete i gymnasiekursen Teknik1". Thesis, KTH, Lärande, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-293164.
In today's world, society has become dependent on technology and most professions use technology in various constellations. With increasing technical development, the competence requirements and working methods have changed. What was previously perceived as an engineer’s way of working has now become a general way of working. That is - working in groups and projects is the way to work in most professions. In a team-based environment, in addition to developed technical competence, a range of non-technical (soft) skills - such as interaction and collaboration with other people, are also required. Technology 1, which is an introductory course to technology in upper secondary schools in Sweden, can be seen as the very first step towards engineering studies - which are at the university level organized and driven according to the CDIO (Conceive, Design, Implement,Operate). CDIO is a model that is widely used in engineering education to improve the way technology is taught and to improve the quality of the workforce. From this perspective, it is interesting to see if the teaching methods of technology 1 at the upper secondary schools - especially group and project work - develop certain abilities and skills that are common to those described in the CDIO-Syllabus. This study will help us better understand whether the National Agency for Education's choice to base technology education with the inspiration from CDIO, introduces students to an engineering way of working and the skills needed for engineering studies that is based on the CDIO-concept. In this study, three technology teachers and six Technology 1 students from different upper secondary schools in Sweden were interviewed, in order to find out their perspectives on abilities and skills - according to the subject's purpose and degree goals - that they perceive that they achieve / develop through group and project work. Furthermore, it was studied whether there is agreement between the students' and the teachers' answers and the learning objectives stated in the CDIO-syllabus. The results of this study show that there are many similarities between learning objectives written in the CDIO-syllabus in relation to the abilities that teachers and students mentioned that they developed by working in project and group work. Mostly, skills related to individual and professional development were developed that include taking responsibility, creative problem solving and analytical skills, communication, systems thinking and collaboration and work in groups of different constellations are a few of them.
Saandi, Thoueiba. "Le gène homéotique Cdx2 : fonctions in-vivo et régulation dans les pathologies intestinales". Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ030.
The Cdx2 gene exerts many functions during embryonic development. Its expression is maintained specifically in the adult intestinal epithelium. Cdx2 expression is reduced in colorectal cancers (CRC); moreover, this reduction promotes migration and the spread of colon tumor cells. The alteration of Cdx2 in CRC is reversible, suggesting a deregulation of the gene. The objectives of my project were to study the functions of Cdx2 during intestinal development and in adults and to study the molecular mechanisms associated with the deregulation of Cdx2 in CRC. An approach of conditional invalidation of Cdx2 in mice has been used. We show that Cdx2 plays a key role in establishing the intestinal identity during development. In addition, at the adult stage Cdx2 is involved in the maintaining of the intestinal stem cells identity and in the control of terminal differentiation of intestinal epithelial cells. Crossing the transgenic mouse model pCdx2-9LacZ with spontaneous colon carcinogenesis model ApcΔ14/+ indicates that the elements necessary for the decrease of Cdx2 expression are located on the Cdx2 promoter of 9kb. Earlier team works have highlighted HNF4α as a transcriptional regulator of Cdx2 expression. In this work, we have demonstrated a correlation between HNF4α and Cdx2 protein expression in samples of human and mouse intestinal tumors. The conditional invalidation of Hnf4α in the intestine is associated with a reduction of Cdx2 expression, and a greater susceptibility for mice to chemo-induced colonic tumorigenesis. HNF4α is an important factor in the deregulation of Cdx2 in CRC and it exerts itself a tumor suppressor function in the gut
Lundin, Jeanette. "Targeted CD52 therapy in lymphoid malignancies : a clinical and immunological study /". Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-441-0/.
Taylor, Vanessa Claire. "Biology of the CD52 antigen, a major glycoprotein of human lymphocytes". Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242883.
Piperi, Christina. "Structural and functional studies on the B cell surface molecule CD22". Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299109.
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