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1
Paquin, Jean-Nicolas. "Réalisation d'un modèle d'interconnexion CCHT sous EMTP-RV". Mémoire, École de technologie supérieure, 2007. http://espace.etsmtl.ca/597/1/PAQUIN_Jean%2DNicolas.pdf.
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Ce document traite de la réalisation d'une interconnexion CCHT sous EMTP-RV. Les travaux effectués dans ce domaine sont tout d'abord passés en revue. La problématique liée à cette technologie est ensuite présentée. Subséquemment, les divers éléments et les systèmes de commande et de protection développés dans le modèle sont détaillés. Les actions portées par les systèmes de protection lors de divers types de défauts sont ensuite mises en évidence. Une validation complète du modèle est présentée. Tout d'abord, ce dernier est comparé avec celui existant sous SPS, une librairie de Matlab/Simulink. Ensuite, la robustesse des commandes et protections est mise à l'épreuve par la simulation du modèle de référence du CIGRÉ dont les conditions d'opération sont sévères. Finalement, le comportement général du modèle en présence de multiples perturbations est analysé à l'aide de résultats obtenus de la simulation de l'interconnexion en configuration bipolaire.
2
Bertolucci, Miguel. "Étude et développement d'une représentation des systèmes de transport d'énergie en CCHT par des fonctions de conversion /". Thèse, Trois-Rivières, Université du Québec à Trois-Rivières, 1999. http://www.uqtr.ca/biblio/notice/resume/03-2205960R.html.
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Bertolucci, Miguel. "Étude et développement d'une représentation des systèmes de transport d'énergie en CCHT par des fonctions de conversion". Thèse, Université du Québec à Trois-Rivières, 1999. http://depot-e.uqtr.ca/3353/1/000663233.pdf.
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Ngo, Hoang-Trung. "Control of power electronics of future smart grids for ancillary services". Electronic Thesis or Diss., Ecole centrale de Nantes, 2023. http://www.theses.fr/2023ECDN0008.
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Afin de fournir des services système etde gérer les intéractions entre convertisseurs, cettethèse a proposé une technique de commandecoordonnée pour les systèmes de convertisseurs depuissance connectés au réseau, avec desimplémentations centralisées et décentralisées. Lesnouvelles structures de commande proposées sontdivisées en différents niveaux de commande/bouclesen fonction de la dynamique naturelle du système : laboucle très rapide est utilisée pour fournir desservices locaux (puissance active/réactive, tensionCC, et inertie du réseau / RoCoF support), la bouclerapide est pour MPPT, la réponse en fréquence et lesservices de tension CA, et la boucle lente estconstituée par sert les commandes secondaires de lafréquence et de la tension. À cet égard, ce contrôleest une alternative à la commande vectorielleclassique. De plus, des techniques de commandeavancées comme H2/H-infini, des approches flouesnon linéaires et des techniques d’IMT, sont utiliséespour obtenir des performances optimales tout enmaintenant une marge de stabilité (p. ex., FRT etCCT). Trois applications ont été traitées :commande décentralisée VSC-CCHT (non linéaire),commande décentralisé/centralisé du systèmeéolien PMSG (non linéaire) raccordé au réseau etcommande en tension (STATCOM) d’unconvertisseur connecté au réseau. La mise enoeuvre décentralisée renforce la résilience lors de lacommande de plusieurs générateurs d’énergierenouvelable, comme dans le concept de centraleélectrique virtuelle dynamique développé dans leprojet H2020 RIA POSYTYF. Les résultats ontdémontré que les structures de commandeproposées sont plus performantes que lacommande vectorielle classique en termes destabilité et de performance. Cette thèse présenteégalement une méthode de conception de systèmede commande conviviale sur la base des approchesprésentées, qui peut ensuite être appliquée auxapplications au niveau industrielIn order to provide ancillary servicesand handling coupling between converters, thisthesis proposed a coordinated control technique forpower converter systems connected to the grid, withboth centralised and decentralised implementations.The new proposed control structures are divided intodifferent control levels/loops based on the system’snatural dynamics: the very fast loop is used toprovide local services (active/reactive power, DCvoltage, and grid inertia/ RoCoF support), the fastloop is for MPPT, frequency response, and ACvoltage services, and the slow loop is for secondaryfrequency and voltage control. In this regard, suchcontrol is an alternative to traditional vector control.Furthermore, advanced control techniques includingMIMO state-space, resilient and optimal H2/H-infinitycontrol, nonlinear fuzzy approaches, and LMItechniques are used to obtain optimal performancewhile maintaining a stability margin (e.g., FRT andCCT). There are 3 applications: VSC-HVDC(nonlinear) decentralised control, grid-connectedwind system PMSG (nonlinear)decentralized/centralized control, and a gridconnectedSTATCOM LMI-based pole-placementcontrol. Decentralized implementation enhancesresilience when controlling several renewablegenerators, such as in the Dynamic Virtual PowerPlant concept developed in the H2020 RIAPOSYTYF project. The results demonstrated thatthe proposed control structures outperform classicalvector control in terms of stability and performance.This thesis also presents an engineering-friendlycontrol system design method based on thepresented approaches, which can then be appliedto industrial-level applications
5
Sethakul, Panarit. "Réseaux électriques et filtrage des harmoniques : mise en œuvre et méthode d’étude". Thesis, Vandoeuvre-les-Nancy, INPL, 2009. http://www.theses.fr/2009INPL083N/document.
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Cette thèse s’intéresse au problème de la qualité de l’énergie électrique sous l’angle particulier des harmoniques, leurs sources, leurs effets et les solutions permettant de les réduire. Deux solutions sont principalement considérées, les convertisseurs à indice de pulsation élevé et les filtres actifs. Ce travail a été mené en faisant porter l’accent sur le réseau électrique thaïlandais. C’est ainsi qu’une présentation de l’évolution de la façon dont l’électricité est produite, transportée et distribuée en Thaïlande est effectuée avant de décrire les contraintes imposées sur les harmoniques. Les différents systèmes de liaison à courant continu haute tension (CCHT) actuellement installés dans le monde sont rappelés avant de décrire en détails les différents composants et le contrôle de la liaison 300-600 MW existant entre la Thaïlande et la Malaisie. Après avoir ensuite présenté les différentes solutions envisageables de réduction des harmoniques, un exemple de réalisation, l’une des premières en Thaïlande utilisant un contrôle numérique, est détaillé afin d’illustrer les avantages de ce type de solution. La thèse se termine sur la présentation d’une méthode originale de modélisation des convertisseurs à indice de pulsation élevé. Cette modélisation repose sur une solution analytique exacte du problème d’état qui est considéré sur le plus petit intervalle permettant, en utilisant des propriétés de symétrie, de reconstruire la période de fonctionnement du dispositif. Le modèle ainsi développé donne des informations sur le fonctionnement du système tant dans les domaines fréquentiel que temporelThe problem of quality of electrical energy is the main object of this thesis. This problem is considered especially from the point of view of harmonics, sources, effects and solutions to reduce them. Two main solutions are considered, multi-pulse converters and active filters. This work is developed with a particular emphasis on the Thai electrical network. Then, the production, transmission and distribution system of electricity in Thailand and the harmonics regulations are presented. The different types of HVDC interconnection systems which are installed in the world today are detailed before presenting the 300/600 MW Thailand-Malaysia HVDC interconnection. After presenting the different possible solutions to avoid harmonics, a realized example, one of the first one developed in Thailand with a numerical control, is detailed to show the advantages of such a solution. The thesis ends on the presentation of an original modelling method of multi-pulse converters. The model is based on an exact analytical solution of the state problem which is considered on the smallest interval, which can, by using property of symmetry, rebuild the whole period. The result model gives the full information on the operation of the whole device both in time and frequency domains
6
Špaček, Matěj. "Návrh manipulátoru vzorku pro CCHM mikroskop". Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2021. http://www.nusl.cz/ntk/nusl-444981.
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In the Laboratory of the Experimental Biophotonics at Brno University of Technology, a new generation of the Coherence-Controlled Holographic Microscope (CCHM) is being developed. Because of the automation of certain microscope procedures, a fully motorized three axis computer controlled manipulator of the sample is to be employed. A fast and accurate lateral positioning in a range of several centimeters is required. For the focusing capability, very precise positioning in the optical axes is required as well. Initially, the basics of microscope manipulator design are presented. Then, commercially available solutions are introduced and compared with special focus on its possible implementation in the new generation of CCHM. However, due to the specific design of the new CCHM, available manipulators are not suitable. Therefore, a new optimized manipulator design is introduced in the second part of the thesis. A selection of its appropriate elements, especially actuators, is based on a review. For the new manipulator design, a technical documentation was made and a testing software was developed. A crucial part of the manipulator was assembled and tested.
7
Gao, Yu. "Innovative Self-Centering Connection for CCFT Composite Columns". Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/78390.
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Concrete filled steel tubes are regarded as ideal frame members in seismic resisting systems, as they combine large axial and flexural capacity with ductility. The combination of the two materials increases the strength of the confined concrete and avoids premature local buckling of the steel tube. These benefits are more prominent for circular than for rectangular concrete filled steel tubes. However, most common connection configurations for circular concrete filled tubes are not economic in the US market due to (a) the desire of designers to use only fully restrained connections and its associated (b) high cost of fabrication and field welding. Research indicates that well designed partially restrained connections can supply equal or even better cyclic behavior. Partially restrained connections also possess potential capability to develop self-centering system, which has many merits in seismic design.
The goal of this research is to develop a new connection configuration between circular concrete filled steel columns and conventional W steel beams. The new connection configuration is intended to provide another option for rapid assembling on site with low erection costs. The proposed connection is based on an extended stiffened end plate that utilizes through rods. The rods are a combination of conventional steel and shape memory alloy that provide both energy dissipation and self-centering capacity. The new connection configuration should be workable for large beam sizes and can be easily expanded to a biaxial bending moment connection.Ph. D.
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Medina, Porcile Catalina. "CCAT-prime telescope holography simulations and surface error analysis". Tesis, Universidad de Chile, 2019. http://repositorio.uchile.cl/handle/2250/170183.
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Tesis para optar al grado de Magíster en Ciencias de la Ingeniería, Mención EléctricaMemoria para optar al título de Ingeniera Civil Eléctrica
El radio-telescopio CCAT-prime (CCAT-p) será construido en el Cerro Chajnantor a 5.600 m.s.n.m en la Región de Antofagasta, Chile. Este telescopio tendrá una configuración CrossedDragone con dos reflectores de 6 m. Esta configuración le otorga un amplio campo de visión con el que podrá iluminar más de 105 detectores. El rango de operación del CCAT-p comprende longitudes de onda desde los 350 µm hasta los 3.100 µm, y en las mejores condiciones climáticas podrá llegar hasta la ventana de 200 µm. Para operar a estas longitudes de onda se necesita que la superficie de los reflectores tenga una alta precisión, por lo que se ha impuesto una meta para el error medio de frente de ondas entre 7 y 10 µm RMS. Los reflectores del telescopio serán construidos mediante un set de paneles que en conjunto conformarán el perfil deseado. Para lograr la precisión requerida, se necesitará implementar un método de medición de errores en la superficie de los reflectores. Se ha escogido con este fin la técnica de holografía de ondas milimétricas. La implementación de técnicas de holografía para el CCAT-p presenta desafíos, debido principalmente a su ubicación, a su configuración óptica y al alto nivel de precisión deseado. Se utilizará una fuente artificial a 300 m del telescopio, lo cual corresponde a su campo cercano , por lo que se necesita estudiar el comportamiento del patrón de radiación a esta distancia. En este trabajo se hacen simulaciones tanto en campo cercano como en campo lejano, bajo distintos escenarios, para así generar datos del comportamiento del telescopio ante estas circunstancias. Por otro lado, ya que el telescopio consta de dos grandes reflectores, el error medido por el sistema de holografía corresponderá a las contribuciones de los errores en la superficie de cada reflector. Para identificar y separar la contribución de cada reflector se propone utilizar los efectos de paralaje sobre la ubicación de los errores producidos al medir en distintas posiciones del plano focal. En este trabajo cada simulación se mide en 4 posiciones distintas del plano focal. Mediante software se generan mapas de error para los distintos escenarios. Con esto se encuentra que los errores en el reflector secundario experimentan un cambio considerablemente mayor en su posición en la apertura, al cambiar la posición de medición en el plano focal, en comparación con los errores en el primario. La holografía del CCAT-p ha sido simulada satisfactoriamente y se ha identificado un comportamiento diferente entre los errores de las superficies de los reflectores.
QUIMAL 180004
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Liou, Anthony Kian-Fong. "Characterisation of the eukaryotic Chaperonin CCT". Thesis, Institute of Cancer Research (University Of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362743.
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King, Mikayala D. A. "Studies on the eukaryotic chaperonin CCT". Thesis, University of Kent, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404534.
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Mucino, Marco. "CCGT performance simulation and diagnostics for operations optimisation and risk management". Thesis, Cranfield University, 2007. http://hdl.handle.net/1826/2806.
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This thesis presents a techno-economic performance simulation and diagnostics
computational system for the operations optimisation and risk management of a CCGT
power station. The project objective was to provide a technological solution to a
business problem originated at the Manx Electricity Authority (MEA).
The CCGT performance simulation program was created from the integration of
existing and new performance simulation codes of the main components of a CCGT
power station using Visual Basic for Applications (VBA) in Excel ®. The
specifications of the real gas turbine (GT) engines at MEA demanded the modification
of Turbomatch, a GT performance simulation code developed at Cranfield University.
The new capabilities were successfully validated against previous work in the public
domain. In the case of the steam cycle, the model for a double pressure once-through
steam generator (OTSG) was produced. A novel approach using theoretical thermohydraulic
models for heat exchangers and empiric correlations delivered positive
results. Steamomatch, another code developed at the university, was used for the steam
turbine performance simulation. An economic module based on the practitioners’
definition for spark spread was developed. The economic module makes use of the
technical results, which are permanently accessible through the user interface of the
system. The assessment of an existing gas turbine engine performance diagnostics
system, Pythia, was made. The study tested the capabilities of the program under
different ambient and operating conditions, signal noise levels and sensor faults. A set
of guidelines aimed to increase the success rate of the diagnostic under the data and
sensor restricted scenario presented by at MEA was generated.
Once the development phase was concluded, technical and economic studies on the
particular generation schedule for a cold day of winter 2007 were conducted. Variable
ambient and operating conditions for each of the 48 time block forming the schedule
were considered. The results showed error values below the 2% band for key technical
parameters such as fuel flow, thermal efficiency and power output. On the economic
side, the study quantified the loss making operation strategy of the plant during the offpeak
market period of the day. But it also demonstrated the profit made during the peak
hours lead to an overall positive cash flow for the day.
A number of optimisation strategies to increase the profitability of the plant were
proposed highlighting the economic benefit of them. These scenarios were based on the
technical performance simulation of the plant under these specific conditions, increasing
the reliability of the study. Finally, a number of risk management strategies aimed to
protect the operations of a power generator from the main technical and economic risk
variables were outlined.
It was concluded that the use of techno-economic advanced tools such as eCCGT and
Pythia can positively affect the way an operator manages a power generation asset
through the implementation of virtually proven optimisation and risk management
strategies.
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Pan, Li. "CCGT power plant fault detection and performance analysis using statistical modelling". Thesis, Queen's University Belfast, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534599.
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Rohman, Mattias Jan. "Biochemical characterisation of chaperonin containing TCP-1 (CCT)". Thesis, Institute of Cancer Research (University Of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313692.
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Zivcec, Marko. "Characterization of the Interferon αβ receptor knockout mouse model of Crimean-Congo hemorrhagic fever (CCHF) and assessment of Adenovirus based CCHF virus vaccine efficacy and correlates of protection". Oxford Journals, 2013. http://hdl.handle.net/1993/23338.
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Crimean-Congo hemorrhagic fever (CCHF) is an inflammatory disease caused by the tick-borne pathogen CCHF virus (CCHFV). CCHFV is widely distributed with a endemic area including central and western Asia, the Middle East, southeastern Europe and the African continent, and can be transmitted to humans directly by tick bite or by contact with body fluids of infected animals or people. Most animals, while susceptible to CCHFV infection, do not display disease signs following infection, therefore, the development of CCHF disease models has been severely hampered. The lack of disease models has resulted in a lack of characterization of disease progression and lack of evaluated clinical countermeasures. The aims of this study were to further characterize a recently reported small animal model, the interferon alpha/beta receptor knockout (IFNAR-/-) mouse model of CCHF and to utilize this model to evaluate the protective efficacy of Adenovirus (Ad) vaccines as well as mechanisms of protection. To achieve the goals of the study hematological, coagulation, virological, pathological and cytokine/chemokine parameters of IFNAR-/- mice were assessed chronologically following CCHFV challenge. Vaccines were developed by construction of Ad expressing CCHFV nucleocapsid protein (Ad-NP) and glycoproteins (complete glycoprotein precursor Ad-GPC, and mature glycoproteins Ad-GN and Ad-GC). IFNAR-/- mice were then evaluated for adaptive immune responses following Ad vaccination and then challenged with a lethal dose of CCHFV and monitored for survival. To determine the roles of humoral and cell mediated adaptive immune responses in protection against CCHFV, experiments using adoptive transfers of Ad vaccinated IFNAR-/- mice to naïve IFNAR-/- mice and depletion of B- and/or T-cells were undertaken. The results demonstrate that IFNAR-/- mice develop an inflammatory, lethal disease following CCHFV challenge that resembles human CCHF; Ad-NP and Ad-NP/Ad-GPC vaccinated IFNAR-/- mice are protected from CCHFV
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challenge; and that humoral responses are essential for protection from CCHFV while T-cell responses are dispensable, at least in this vaccine platform, in this animal model. These studies provide the basis for more detailed work in vivo and suggest which mechanisms of protection may be important for subsequent advances in CCHFV vaccinology.
15
Cavallina, Francesco. "Progettazione elettromagnetica di un dipolo superconduttivo in configurazione CCT". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.
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La tesi analizza la configurazione magnetica con avvolgimenti inclinati (CCT),presentandone le caratteristiche e le principali applicazioni, e viene svolto un lavoro di progettazione elettromagnetica nell'ambito del progetto BISCOTTO; una collaborazione tra l'università di Bologna e l'INFN di Milano e Genova. In particolare, il primo passo consiste nella realizzazione della geometria che permetterà il successivo calcolo del campo di induzione al centro del magnete. Inoltre, viene effettuato il calcolo del campo sull'asse del conduttore e sulla superficie dello stesso, utilizzando il codice numerico Mag3ds per la risoluzione. In conclusione vengono presentate le considerazioni finali alla luce del confronto con il laboratorio di Milano sui risultati ottenuti.
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Altschuler, Gabriel Martin. "Protein folding studies on the actin-CCT chaperone system". Thesis, Institute of Cancer Research (University Of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440520.
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Stuart, Sarah Frances. "Kinetic studies of actin folding by the chaperonin CCT". Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/9702.
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The chaperonin containing TCP1 (CCT) is an essential protein in eukaryotes, and is vital for the correct folding of various obligate substrates including the cytoskeletal proteins actin and tubulin and the WD40 repeat containing proteins Cdc20 and Cdh1. CCT is highly complex and interacts with some proteins only transiently; as such the study of the mode of binding and the mechanism by which proteins are folded by the molecular chaperone is very challenging. I have used spectroscopic techniques to study the folding of Cdh1 and actin by CCT. The dimensions of CCT are such that Förster resonance energy transfer (FRET) could be used to measure distances within the complex, providing that fluorophores could be selectively introduced. Through labelling of a fragment of the WD40 propeller of Cdh1 and binding of a fluorescently labelled calmodulin (CaM) to the calmodulin binding peptide (CBP) tag introduced into two CCT subunits, it was hoped that subunits which bind to this region of Cdh1 could be identified. Following expression and purification of a stable Cdh1 fragment, methods for selective labelling of the protein were developed. The complex formed between the fluorescently labelled Cdh1 fragment, CaM and CCT was isolated by sucrose gradient. Unfortunately, no significant, reproducible FRET signal could be identified, indicating that this technique was not suited to the study of Cdh1 folding by CCT. Actin is an essential eukaryotic protein which polymerises to form filaments involved in many different cellular processes. CCT subunits which interact with actin have been identified, but the mechanism by which actin is folded is not well understood and has previously relied on the trapping of actin-CCT complexes from non-functional systems. Since the discovery of PLP2 as a cofactor involved in the actin folding process in yeast, pure in vitro actin assays have been possible. Through labelling of the C-terminus of actin with the environmentally sensitive fluorophore acrylodan, it was possible to monitor the kinetics of actin folding by CCT spectroscopically. Non-hydrolysable ATP analogues were used which allowed the identification of two separate stages in the actin folding process on CCT, an initial rearrangement of the two domains of actin followed by packing of the actin C-terminus. The importance of the actin C-terminus in actin folding and stability was highlighted by the effect of the probe with which actin was labelled on folding. The effect of mutations in CCT on the rate of actin folding was also investigated using the spectroscopic folding assay, as well as the effect of truncations of PLP2. It was found that the mutant CCTanc2, which is from a strain of yeast that produces defective actin structures and contains a mutation in subunit CCT4, behaves differently to wild type CCT at higher temperatures and concentrations of ATP. PLP2 appears to be exceptionally important for productive actin folding by CCTanc2.
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Kruger, J. C. "Adaptation of Luborsky's Core Conflictual Relationship Theme (CCRT) method a phenomenological case study /". Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-10222007-110453/.
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Erler, Jens [Verfasser]. "Spectro-spatial observations of galaxy clusters with Planck and CCAT-prime / Jens Erler". Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1218475005/34.
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Allaire, Tanguay Dominique. "Étude d'un système de trigénération décentralisé en climats canadiens". Mémoire, Université de Sherbrooke, 2011. http://hdl.handle.net/11143/5945.
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Ce mémoire présente l'étude d'un système de trigénération ou CCHP (combined cooling, heating and power) au gaz naturel fournissant les besoins thermiques à un immeuble à logement typique de 13 étages. Un groupe électrogène permettant de générer de l'électricité tout en fournissant de l'eau chaude assure le chauffage du bâtiment et de l'eau chaude sanitaire tandis qu'une machine à absorption ammoniac-eau permet de transformer cette chaleur en puissance frigorifique afin de climatiser le bâtiment en période chaude. Le modèle de cette machine à absorption a spécialement été conçu pour fonctionner avec une température de désorption basse et permet d'évaluer les performances de telles machines dans des situations hors design. Ce modèle a été vérifié à l'aide d'autres modèles avérés et propose des coefficients de performance de l'ordre de 0,7 à 0,8. L'évaluation des performances horaires de ce système est présentée pour une année standard sous trois climats canadiens. Ces performances sont ensuite comparées aux différentes méthodes employées pour assurer ces besoins ainsi que pour générer l'électricité supplémentaire. Les résultats démontrent d'excellentes performances même lorsque comparées aux plus récentes technologies. Les résultats passent d'une légère augmentation de la consommation de gaz naturel dans un climat chaud comme Toronto à une importante réduction dans un climat froid comme Edmonton. Ce système permet donc de combler les besoins thermiques d'un bâtiment tout en générant de l'électricité dans des périodes de pointes annuelles et possiblement journalières. Plusieurs études dont notamment l'optimisation du système et le couplage à d'autres types de bâtiment permettrait cependant de mieux évaluer les possibilités complètes de la trigénération.
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Seaby, Thomas David. "Single molecule studies on actin folding by the eukaryotic chaperonin CCT". Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/25137.
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The eukaryotic, cytosolic chaperonin containing TCP-1 (CCT) is a protein folding nanomachine. CCT is a 1 MDa double-ring-structured ATPase which assists nascent polypeptides to reach their native conformational state. Obligate substrates include the cytoskeletal components actin and tubulin. Whilst significant structural studies have been conducted, relatively little is known about the dynamics of the ATP-dependent folding process. Total Internal Reflection Fluorescence (TIRF) microscopy is a high signal to noise, single molecule, microscopy technique which has been previously used to observe both protein dynamics and extract enzyme kinetics at the single molecule level. We have immobilised functional CCT onto silica surfaces in order to extract dwell times and kinetics of the folding process, as CCT captures, folds and releases actin from its unfolded state to the folded G-actin monomer. A method for the immobilisation of CCT, via a calmodulin protein, has been developed. Mutant CCT-6CBP has a calmodulin binding peptide tag inserted into the apical domain of the CCT6 subunit and can be affinity captured via calmodulin immobilised to a borosilicate surface. The calmodulin-CCT interaction is calcium dependent and can be reversed allowing for discrimination between specific versus non-specific binding. ATP-dependent release of unfolded actin from CCT complexes immobilised to silica surfaces has proven to be problematic. Complexes can be specifically bound but subsequently seem to lose functional folding behaviour. Attempts to count the numbers of the stimulatory cofactor phosducin-like protein 2 (PLP2) and actin monomers bound to the CCT complex, utilising photobleaching, is described. A program for the analysis of single molecule traces was written. Incorporating a Chung-Kennedy non-linear filter, this program provides stoichiometric data consistent with spectrophotometric methods. Analysis of CCT-actin-PLP2 complexes was not possible due to time constraints.
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Tensmeyer, Nicole C. "The Role of the Chaperone CCT in Assembling Cell Signaling Complexes". BYU ScholarsArchive, 2020. https://scholarsarchive.byu.edu/etd/9192.
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In order to function, proteins must be folded into their native shape. While this can sometimes occur spontaneously, the process can be hindered by thermodynamic barriers, trapped intermediates, and aggregation prone hydrophobic interactions. Molecular chaperones are proteins that help client proteins or substrates overcome these barriers so that they can be folded properly. One such chaperone is the chaperonin CCT, a large MDa protein made up of 16 paralogous subunits that form a double ring structure. CCT encapsulates its substrates in a central cavity, where they are sequestered and folded, using ATP binding and hydrolysis to drive conformational changes in the CCT-substrate complex. CCT mediates the folding of many substrates involved in a variety of cellular process, including the cytoskeletal proteins actin and tubulin, and the G protein subunit Gabg, which signals downstream of GPCRs in a variety of cellular processes. We showed that CCT is responsible for folding the b-propeller containing proteins, mLST8 and Raptor, which are subunits of the mTOR complexes. The mTOR complexes (mTORC1 and mTORC2) are master regulators of cell growth and survival by controlling processes such as protein synthesis, energy metabolism, cell survival pathways and autophagy. CCT folds mLST8 and Raptor and help them assemble into the mTOR complexes. As a result, CCT is required for functional mTOR signaling. Furthermore, we solved a 4.0 Ǻ resolution structure of mLST8 bound to CCT. Surprisingly, mLST8 is found in the center of the folding cavity, in between the rings, despite previous evidence suggesting that substrates bind only in the apical domains. Given its role in folding and assembling the mTOR complexes, G proteins, and many other proteins involved in cell survival pathways, CCT has been implicated in cancer. CCT upregulation often correlates with a worse prognosis, likely because uncontrolled growth requires increased chaperone capacity. The peptide CT20P has been shown to have cytotoxic effects in cancer cells, likely through its binding to CCT. We characterized CT20P, showing that it binds to CCT and inhibits its substrate-folding functions in cells. We specifically showed that a GFP-CT20P fusion protein inhibited the assembly of two important signaling complexes Gbg and mTORC1. These results show that CT20P is a useful inhibitor for the study of CCT function.
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Whitmire, Brian Edward. "OPTIMIZATION OF COMBINED COOLING, HEATING, AND POWER SYSTEMS (CCHP) OPERATIONAL STRATEGIES FOR DIFFERENT CLIMATE CONDITIONS". MSSTATE, 2009. http://sun.library.msstate.edu/ETD-db/theses/available/etd-04032009-122031/.
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This thesis investigates the different strategies of operation and optimization criteria that a CCHP system can be operated under. As energy concerns increase, a major issue for the United States will be the efficiency of energy production. Due to this desire for the most efficient supply of energy CCHP will play an increasingly important role in both domestic and commercial applications as waste heat utilization provides an added measure of efficiency. The different strategies of operation under which a CCHP system can be operated under, electric load following and thermal load following, are defined in addition to the different optimization criteria that a CCHP system can be operated under. The different strategies and optimization criteria of CCHP operation are simulated for five various climate regions in the United States and the results for primary energy consumption, CO2 emissions, and cost of operation are compared.
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Knight, D. W. "Microwave studies of molecules with asymmetric internal rotors : CH₂DNO, CHD₂NO and CIF₂CCHO". Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356220.
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Du, Eliane. "Factors that impact on the usability of computerised cognitive behavioural therapy (CCBT) : mixed methods studies". Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/22999.
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Computerised Cognitive Behavioural Therapy (CCBT) has been recommended for patients in the National Health Service (NHS) Primary Care across the United Kingdom for management of mild to moderate anxiety and depression. This approach also promises financial savings, and may fill the gap between demand and supply of face-to-face therapy. Studies have shown that CCBT is feasible and effective. However, dropout rates can be as high as 86%, but the reasons remain unclear and the information available is limited. This thesis explores factors that may impact on the usability and user experience of this computer-mediated therapy. Espousing the “real world” research philosophy and widely used methods in the Human-Computer Interaction (HCI) field for usability evaluations, four studies using a mixed-methods design were conducted. Study I was an online usability survey, which investigated if usability evaluations had been conducted for CCBT applications. Two versions of questionnaires were sent to four CCBT software developers and ten authors of randomised controlled trials. The categories and responses of the questionnaires gathered from five respondents were reviewed and summarised. The findings suggested that usability evaluations for CCBT were still in their infancy when compared to other healthcare interventions to which HCI approaches have been widely applied. Study II was a usability Heuristic Evaluation (HE) conducted with four expert evaluators to assess two different CCBT applications’ interfaces (MoodGYM and Living Life to the Full) against the self-designed usability heuristics for their compliance. The findings revealed numerous usability issues. Major problems related to navigation and inconsistency of the interfaces were identified. These could be rectified to enhance the user experience. Study III focused on other factors besides usability that might have an influence on the effective use of CCBT. Perceptions of service providers who were involved in both decision-making about CCBT availability and supporting its use were gathered. Nine service providers at different NHS organisations were interviewed. The interviews were analysed using techniques from Grounded Theory (GT). The findings suggested that the practitioners’ attitudes towards CCBT might have affected its service delivery. Four categories from the data analysis were identified: (1) shaping behaviour, (2) implementing and delivering, (3) making an appropriate referral, and (4) technology/CCBT packages - advancing with time. A conceptual model was also generated, “building support around CCBT”: a road-map that could address some of these issues. Study IV examined patients’ perceptions and acceptance of a CCBT application (Beating the Blues), its usability and the user experience, and also whether the user characteristics (e.g. computer experience (CE) and computer self-efficacy (CSE)) had any influence on patients’ use of this technology. A mixed-methods approach was utilised with a sample of 33 participants. Face-to-face and email interviews were conducted. Feedback was also gathered from a usability questionnaire and think-aloud protocol with seven participants selected from the sample. The data were analysed using Thematic and Saliency Analysis to uncover themes. Descriptive statistics were used to describe data from questionnaires. Two overarching themes from the interviews were identified: (1) access to CCBT services, and (2) perceptions and attitudes towards CCBT. Both themes revealed issues which might have significantly impacted on patients’ engagement with CCBT. Numerous flaws were also discovered in the application’s design and functionality (e.g. navigation, aesthetics, relevance of content, and inflexibility). However, the results from CE and CSE questionnaires suggested that participants were confident in using this technology. The four studies provided an in-depth understanding of factors that affect the usability and user experience of CCBT and possible reasons for the high attrition rates. The implications of this research point to the need for health policymakers to focus on the current implementation issues and on how best to deploy this treatment therapy to patients. Further development of CCBT is pivotal to its success, in particular, expanding contexts of use and increasing usability evaluations. Keeping users interested and engaged will improve treatment efficiency, completion rates and will achieve better clinical outcomes.
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Curto, Rita de Cássia Siqueira. "Estudo comparativo entre duas cepas de Saccharomyces cerevisiae CCT 1530 e CCT 1531 para a produção de proteínas unicelulares a partir de hidrolisado de amido de mandioca /". reponame:Repositório Institucional da UFSC, 1998. http://repositorio.ufsc.br/xmlui/handle/123456789/77994.
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Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.Made available in DSpace on 2012-10-17T09:23:06Z (GMT). No. of bitstreams: 0Bitstream added on 2016-01-08T23:25:19Z : No. of bitstreams: 1 137698.pdf: 29310314 bytes, checksum: 914f12035ecedbbf41bf1c8ffe85a7b5 (MD5)
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Choi, Young-Chool. "Privatisation of local government services : the politics of transaction cost". Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242380.
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Silveira, Silvana Magayevski da. "Conflitos nos relacionamentos de genitores em situação de disputa de guarda: uma contribuição para a compreensão da alienação parental". Universidade do Vale do Rio dos Sinos, 2013. http://www.repositorio.jesuita.org.br/handle/UNISINOS/4897.
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Esta dissertação de mestrado partiu da constatação de que existe a necessidade de um aprofundamento no estudo de situações de disputa de guarda, especialmente no que diz respeito à avaliação e intervenção em situações que implicam alienação parental. Está dividida em dois artigos. O primeiro artigo é teórico e apresenta os termos alienação parental e síndrome de alienação parental, descreve os comportamentos apresentados pelos genitores envolvidos neste tipo de configuração relacional conflitiva e revisa as discussões e estudos brasileiros sobre o tema, visando contextualizar este problema ainda pouco conhecido e estudado empiricamente. O segundo artigo é um estudo de casos múltiplos que propõe avaliar os padrões conflitivos nos relacionamentos apresentados por genitores envolvidos na alienação parental, sendo 2 alienados e 2 alienadoras. Os casos foram coletados e analisados em conformidade com o método CCRT (Core Conflictual Relationship Theme), de Lester Luborsky. Através de entrevistas, colheu-se o depoimento dos participantes sobre a separação e situação atual e obteve-se o relato de diversas situações interpessoais, o que possibilitou a obtenção do CCRT ou tema central de conflito nos relacionamentos. Os resultados indicam que o desejo principal das pessoas envolvidas na dinâmica de alienação parental é de ser amado e compreendido e que a perda deste amor seja um fator de vulnerabilidade.
This thesis started from the finding that there is a need for a deeper study of child custody situations, especially regarding to assessment and intervention in situations which parental alienation is involved. It is divided into two articles. The first article is theoretical and introduces he terms parental alienation and parental alienation syndrome. It describes the behavior displayed by the parents involved in this type of conflictual relationship and reviews the discussions and Brazilian studies on this issue in order to contextualize this problem still little known and empirically studied. The second article is a multiple case study that aims to evaluate standard conflicts in relationships presented by parents involved in parental alienation, being 2 alienated and 2 alienating. The cases were collected and analyzed in accordance with the method CCRT (Core Conflictual Relationship Theme) by Lester Luborsky. Through interviews, a testimony about separation and current situation of participants was collected and an account of several interpersonal situations was obtained, which allowed obtaining the CCRT or central theme of conflict in relationships. The results indicate that the main desire of the people involved in the dynamics of parental alienation is to be loved and understood and that the loss of this love is a vulnerability factor.
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Massei, Ariane Cristina. "Propriedades psicom?tricas do question?rio de relacionamento central (CRQ) em portadores de HIV/AIDS". Pontif?cia Universidade Cat?lica de Campinas, 2009. http://tede.bibliotecadigital.puc-campinas.edu.br:8080/jspui/handle/tede/235.
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Previous issue date: 2009-02-27Pontif?cia Universidade Cat?lica de Campinas
The interpersonal relationships are important facets of individuals lives, and for those who suffer from chronic diseases, the presence of relationships helps on facing the illness and acceptation of the treatment. The AIDS is an infectious disease, chronic and transmittable, caused by the HIV virus contamination. This contamination caused by AIDS brings physical consequences (lipodystrophy and metabolically disturbs, for example) and psychological ones too, such as anxiety, depression, impotence feelings and apathy, affecting specifically the relation-affective field (prejudice, rejection). The aim of study was to evaluate the psychometrical properties of the Portuguese version of the Central Relationship Questionnaire (CRQ 6.0) of HIV positive outpatients. The CRQ 6.0 is a self-report instrument, based on the Core Conflictual Relationship Theme (CCRT) whose as goal is to assess the central relationship pattern of romantic partners, according to three components: Wish (W), Responses from de Other (RO) and Responses of Self (RS). To the Valid Convergent of CRQ 6.0 study, it was used as external criteria the Symptoms Evaluation Scale (EAS-40), which evaluates psychopathological symptoms. The sample was composed of 50 individuals diagnosed with HIV(G1; 60% male; average age:41,84 years old) and 40 people accompanying other patients to the hospital (G2; 62,5% female; average age: 34 years old). As about the results, the CRQ 6.0 has presented good internal consistence, with Cronbach Alpha coefficients ranging from 0.80 to 0.87 similarly to other international researches. The CRQ 6.0 has presented as well, evidences of convergent validity, with positive and significant association between each one of the CRQ 6.0 components and factors from EAS-40 (from 0.23 to 0.57). Results pointed yet to evidences of discriminant validity of the CRQ 6.0 and EAS-40, with significant differences between G1 and G2 (Mdn from G1= 3,09; Mdn from G2= 2,78; p= 0,032) and between female and male to D from G1 (Mdn fem. = 2,43; Mdn male= 2,03; p= 0,014). Researches with large samples should be conducted .
Os relacionamentos interpessoais s?o parte importante da vida dos indiv?duos, e, para pessoas que sofrem de doen?as cr?nicas, a presen?a dos relacionamentos auxilia no enfrentamento da doen?a e ades?o ao tratamento. A S?ndrome da Imunodefici?ncia Adquirida (SIDA/AIDS) ? uma doen?a infecciosa, cr?nica e transmiss?vel, causada pela contamina??o pelo V?rus da Imunodefici?ncia Humana (HIV). A contamina??o pela AIDS traz conseq??ncias f?sicas (lipodistrofia e disturbios metab?licos, por exemplo) e psicol?gicas, como ansiedade, depress?o, sentimentos de impot?ncia e apatia, afetando especificamente no campo afetivo-relacional (preconceito, rejei??o).O estudo teve como objetivo avaliar as qualidades psicom?tricas da vers?o em portugu?s do Question?rio de Relacionamento Central (CRQ 6.0) junto a pacientes HIV positivos, em tratamento ambulatorial. O CRQ 6.0 ? um instrumento de auto-relato, baseado no m?todo Tema Central de Relacionamento Conflituoso (CCRT) que tem como objetivo identificar o padr?o de relacionamento central de parceiros amorosos, de acordo tr?s componentes: Desejo (D), Respostas do Outro (RO) e Respostas do Eu (RE). Para o estudo de validade convergente do CRQ 6.0, foi utilizado como crit?rio externo a Escala de Avalia??o de Sintomas (EAS-40), que avalia sintomas psicopatol?gicos. A amostra foi composta por 50 indiv?duos com diagn?stico de HIV (G1; 60 % do g?nero masculino; idade m?dia de 41,84 anos) e 40 acompanhantes de pacientes de outras enfermarias (G2; 62,5% do g?nero feminino; idade m?dia de 34 anos). Quanto aos resultados, o CRQ 6.0 apresentou boa consist?ncia interna, com coeficientes de alfas de Cronbach variando de 0,80 a 0,87 semelhantes aos dados encontrados em outras pesquisas internacionais. Apresentou tamb?m evid?ncias de validade convergente, com associa??es positivas e significantes entre alguns componentes do CRQ 6.0 e fatores da EAS-40 (de 0,23 a 0,57). Os resultados apontam ainda para evid?ncias de validade discriminante do CRQ 6.0 e EAS-40, com diferen?as significantes nos escores entre G1 e G2 para o componente RE (Mdn do G1= 3,09; Mdn do G2= 2,78; p= 0,032) e entre sexo feminino e masculino para D do G1 (Mdn do sexo fem. = 2,43; Mdn do sexo masc.= 2,03; p= 0,014). Pesquisas com amostras maiores devem ser realizadas.
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Dchar, Ilyas. "Conception d’un module d’électronique de puissance «Fail-to-short» pour application haute tension". Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEI042/document.
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Les convertisseurs de forte puissance sont des éléments critiques des futurs réseaux HVDC. À ce titre, leur fiabilité et leur endurance sont primordiales. La défaillance d’un composant se produit soit en circuit ouvert, ou en court-circuit. Le composant défaillant en circuit ouvert est inadmissible pour les convertisseurs utilisant une topologie de mise en série. En particulier, dans certaines applications HVDC, les modules doivent être conçus de telle sorte que lorsqu'une défaillance se produit, le module défaillant doit se comporter comme un court-circuit et supporter ainsi le courant nominal qui le traverse. Un tel comportement est appelé “défaillance en court-circuit” ou “failure-to-short-circuit”. Actuellement, tous les modules de puissance ayant un mode de défaillance en court-circuit disponibles dans le commerce utilisent des semi-conducteurs en silicium. Les potentialités des semi-conducteurs en carbure de silicium (SiC) poussent, aujourd’hui, les industriels et les chercheurs à mener des investigations pour développer des modules Fail-to-short à base des puces SiC. C’est dans ce contexte que se situe ce travail de thèse, visant à concevoir un module à base de puces SiC offrant un mode de défaillance de court-circuit. Pour cela nous présentons d’abord une étude de l’énergie de défaillance des puces SiC, afin de définir les plages d’activation du mécanisme Fail-to-short. Ensuite, nous démontrons la nécessité de remplacer les interconnexions classiques (fils de bonding) par des contacts massifs sur la puce. Enfin, une mise en œuvre est présentée au travers d’un module “demi pont” à deux transistors MOSFETThe reliability and endurance of high power converters are paramount for future HVDC networks. Generally, module’s failure behavior can be classified as open-circuit failure and short-circuit failure. A module which fails to an open circuit is considered as fatal for applications requiring series connection. Especially, in some HVDC application, modules must be designed such that when a failure occurs, the failed module still able to carry the load current by the formation of a stable short circuit. Such operation is referred to as short circuit failure mode operation. Currently, all commercially available power modules which offer a short circuit failure mode use silicon semiconductors. The benefits of SiC semiconductors prompts today the manufacturers and researchers to carry out investigations to develop power modules with Fail-to-short-circuit capability based on SiC dies. This represents a real challenge to replace silicon power module for high voltage applications in the future. The work presented in this thesis aims to design a SiC power module with failure to short-circuit failure mode capability. The first challenge of the research work is to define the energy leading to the failure of the SiC dies in order to define the activation range of the Fail-to-short mechanism. Then, we demonstrate the need of replacing the conventional interconnections (wire bonds) by massive contacts. Finally, an implementation is presented through a "half bridge" module with two MOSFETs
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Hanna, Melissa. "Decision-making processes and experiences of older people using the Beating the Blues computerised cognitive behavioural self-help programme : a qualitative study". Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7801.
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Introduction: Current recommendations by National Institute of Clinical Excellence (Technology Appraisal 51) emphasise the need for future research to examine the effectiveness of CCBT across the age span. Kaltenthaler et al. (2008) recommended future research focuses on acceptability of CCBT through using ‘survey and intensive qualitative methods, include the process of initial engagement, continuation versus drop-out, and in those completing, satisfaction or regret undertaking CCBT’ (p.1528). The pilot study by McMurchie (2011) was the first to explore the acceptability and effectiveness of the CCBT package Beating the Blues (BTB) solely with older people. Using qualitative methodology, the aim of the current study was to explore the experiences of older people who, when participating in the pilot study chose to use BTB compared to those who chose to remain with their treatment as usual (TAU). The current study aimed to gain a deeper understanding of the acceptability of BTB as well as factors that influence decisionmaking in terms of uptake to BTB and discontinuation from BTB. Method: Individual semi-structured interviews were carried out with 20 older people who took part in the pilot study (McMurchie, 2011). Participants were in one of three groups, these were: BTB-completers, BTB-discontinuers and TAU. Transcripts were analysed using Interpretative Phenomenological Analysis (IPA) (Smith et al., 2009). Findings: Five master themes emerged from the interviews: Beating the Blues as a Process of Change; Relevance of Beating the Blues to Older People; Challenges of Using Beating the Blues; Motivation to Try Something New and Barriers to Beating the Blues at Time of Uptake. Conclusions: Overall, the master themes reflected the experiences of either “regaining control” or a sense of “hopelessness” when opting whether or not to use BTB in the first instance and to then continue with the treatment. Experiences of using BTB appeared to be linked to the outlook participants had about using a novel treatment with either a sense of hope or impending failure. Participants who chose BTB had a more positive outlook which impacted their ability to manage perceived challenges and work towards recovery. The sense of impending failure seemed to be linked to participants perceiving more barriers to using BTB and struggling to overcome these challenges, resulting in them either declining BTB or feeling they were not benefiting from BTB and therefore discontinuing it.
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Kane, Michael J. "The management of change in Scottish Local Authorities : the experience of CCT". Thesis, Glasgow Caledonian University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320701.
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Kuang, Yin. "Generation of TTT and CCT curves for cast Ti-6Al-4V alloy". [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0004560.
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Parizzi, Jocemar Biasi. "Utilização avançada da capacidade excedente de sistemas de transmissão CCAT para produção de oxigênio e hidrogênio". Universidade Federal de Santa Maria, 2008. http://repositorio.ufsm.br/handle/1/3654.
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Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorThis PhD thesis discusses the use of the power plant capacity in HVDC transmission systems during inactive periods of the main converters to feed local loads, aiming at a better AC power quality and DC transmission. The power available in the inactive periods is drained by an auxiliary converter connected in parallel with the HVDC converter. This energy can be used to: feed thermal equipments; battery charging; supply of local services; AC power re-injection; and to produce high purity hydrogen and oxygen through electrolysis. The overall control was designed to improve the power transmission quality at the AC side of the HVDC plant. Simulated and lab practical results from a reduced model of a HVDC plant and from the auxiliary converter connected in parallel with the main converter are presented. The proposed arrangement of converters demonstrates the possibility of THD reduction and increase of the power and utilization factors, without disturbing the efficiency of the HVDC transmission system, and making evident loss reduction, sizing of the harmonic filters and PF reactors. For their special characteristics, at the end of this thesis it is presented the state of art of the auxiliary converter energy utilization to produce hydrogen and oxygen through water electrolysis.
Esta tese discute o uso da capacidade instalada dos sistemas de transmissão CCAT nos períodos inativos das chaves eletrônicas dos conversores de potência para alimentar cargas locais, de tal modo que a qualidade da energia e a transmissão em corrente contínua possam ser amplamente melhoradas. A energia dos períodos inativos é drenada por um conversor auxiliar conectado em paralelo com o conversor CCAT. Esta energia pode servir para: alimentar equipamentos térmicos; carregar baterias; suprir serviços ancilares; retro-injeção na rede; e produção de hidrogênio e oxigênio por eletrólise com alto grau de pureza, entre outras cargas. O controle dos conversores conectados em paralelo foi projetado criteriosamente visando melhorar a qualidade da energia no lado CA da planta de CCAT. São apresentados dados provenientes da adição do conversor auxiliar em paralelo com o conversor CCAT, tanto de simulações como de dados reais e ensaios de laboratório em um protótipo em escala reduzida. Com o arranjo de conversores proposto nesta tese fica demonstrada a possibilidade de uma redução considerável da distorção harmônica total e o aumento dos fatores de potência e de utilização, sem prejudicar o rendimento da transmissão CCAT. Também fica evidente a redução de perdas e do tamanho dos filtros harmônicos e reatores de compensação de reativos por diminuir a corrente nos mesmos. Pela sua peculiaridade, no final desta tese é apresentado um estudo sobre o estado da arte da utilização da energia processada por conversores auxiliares junto a conversores CCAT para a produção de hidrogênio e oxigênio através da eletrólise de água.
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CARVALHO, Suzana Mensch de. "Implementação de um Sistema de Transmissão em CCAT utilizando um Simulador Digital em Tempo Real - RTDS". reponame:Repositório Institucional da UNIFEI, 2017. http://repositorio.unifei.edu.br/xmlui/handle/123456789/840.
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A validação de sistemas de proteção através do uso do simulador RTDS (Real Time Digital Simulator) permite a criação de um ambiente de testes que, em termos de transitórios eletromagnéticos, se aproxima muito das condições reais às quais os equipamentos de proteção estarão submetidos quando estiverem instalados em campo. A fidelidade deste ambiente criado em laboratório dependerá das características do modelo do sistema de potência em questão implementado no software do RTDS. No caso de ITAIPU, por exemplo, até o desenvolvimento da pesquisa apresentada nesta dissertação, todos os ensaios de sistemas de proteção do setor de 50 Hz consideravam o sistema de transmissão em CCAT (Corrente Contínua em Alta Tensão) de forma simplificada, através de uma carga. Desta forma, o intuito desta dissertação é a apresentação de um novo modelo do sistema de transmissão de ITAIPU no RTDS, com um detalhamento maior do setor de 50 Hz, através da representação monopolar do sistema em CCAT. Através de análises comparativas entre este novo modelo e aqueles utilizados anteriormente chegou-se à conclusão de que as diferenças entre eles são sutis e que a escolha de um modelo mais simplificado ou de um mais detalhado deverá ser feita considerando-se o compromisso entre os fenômenos transitórios que se deseja representar e as limitações de hardware e software impostas pelo RTDS.
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Lin, Yung-Wei (Dennis). "Contemporary Research on Child-Centered Play Therapy (CCPT) Modalities: A Meta-Analytic Review of Controlled Outcome Studies". Thesis, University of North Texas, 2011. https://digital.library.unt.edu/ark:/67531/metadc68001/.
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The present meta-analytic study estimated the overall effectiveness of child therapy interventions using CCPT methodology and explored the relationships between study characteristics and treatment effects. Fifty-two studies between 1995 and the present were included based on the following criteria: (a) the use of CCPT methodology, (b) the use of control or comparison repeated measure design, (c) the use of standardized psychometric assessment, and (d) clear reports of effect sizes or sufficient information for effect size calculation. Hierarchical linear modeling (HLM) techniques were utilized to estimate the overall effect size for the collected studies and explore relationships between effect sizes and study characteristics. Dependent variable included 239 effect sizes, and independent variables included 22 study characteristics. The mean age of all child participants in the collected studies was 6.7. In 15 studies, the majority of participants were Caucasian. An equal number of studies were made up of non-Caucasian participants, including 3 with majority African American, 4 with majority Hispanic/Latino participants, 5 with majority Asian/Asian American participants, and 3 with other ethnic populations. Study collection included 33 studies with majority of boys and 11 studies with majority of girls. HLM analysis estimated a statistically significant overall effect size of 0.47 for the collected studies (p < 0.001). This result indicated that the overall improvement from pre to post treatment demonstrated by children in experimental groups was approximately 1/2 standard deviation better than by children in control groups. A statistically significant amount (49.2%) of between-study variance was found (p < 0.001), indicating the heterogeneity among the 52 studies Statistically significant relationships were found between effect sizes and study characteristics including child age, child ethnicity, clinical level of referral, treatment integrity, presenting issue, source of data, population, and caregiver involvement. Effect size findings for CCPT and its moderators should be interpreted in light of the specific, and perhaps more rigorous statistical analysis method (HLM) and effect size calculation formula used for the present study, particularly in comparison to previous meta-analytic findings. Overall findings support CCPT's beneficial treatment effect. Specifically, CCPT can be considered a developmentally and culturally responsive effective mental health intervention across presenting issues.
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Prione, Lilian Parra. "Adaptação bacteriana: plasticidade fenotípica de Pantoea ananatis CCT 7673 exposta ao herbicida mesotrione". UNIVERSIDADE ESTADUAL DE PONTA GROSSA, 2014. http://tede2.uepg.br/jspui/handle/prefix/979.
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Herbicides are widely used to increase crop production and account for 35% of all agrochemicals applied annually. After application, the herbicides can remain in the soil as hazardous residues. Mesotrione, (2-[4-methylsulfonyl-2-nitrobenzoyl]1,3-cyclohenanedione), is the active ingredient of Callisto, an herbicide commonly used in corn. Pantoea ananatis CCT 7673, an Enterobacteria isolated from water, has been previously cited as mesotrione-degrading strain. The aim of this study was to evaluate the influence of mesotrione and Callisto as oxidative stress-inducing agents for cellular metabolism of Pantoea ananatis CCT7673 and identify possible mechanisms of tolerance. SOD, CAT and GR activities were evaluated in non-denaturing PAGE and CAT, GR and GST in spectrophotometer. Also, the rates of malonaldehyde (MDA), superoxid and peroxide hydrogen (H2O2) were measured in a spectrophotometer. Minimal medium with no herbicide (MM) was used as control. Lipid peroxidation, superoxide and peroxide hydrogen quantification and SOD, CAT, GR and GST activities were analyzed before and after degradation of mesotrione. The herbicide proved to be the cause of oxidative stress, according to peroxide hydrogen data. Unexpectedly, the rates of lipid peroxidation (MDA) and GR showed to be lower in the presence of the herbicide when compared to the control, with no changes in bacterial growth. The activity of GST was higher in mesotrione treatment in comparison to control and Callisto, during and after degradation. These results suggest that this enzyme may be related to the mesotrione degradation, probably by cometabolism. The rates of lipid peroxidation were shown to be lower in the presence of the herbicide compared to the control, with no changes in growth rates when exposed to herbicide. P. ananatis CCT 7673 showed changes in the saturation of membrane lipids. These changes may interfere with herbicide entry into the cell. These characteristics may be associated with a level of phenotypic plasticity in P. ananatis CCT 7673, making this an interesting bacterium for studies of herbicide tolerance and evolution of microbiota in environments subjected to different degrees of selective pressure model.
Herbicidas são amplamente utilizados para aumentar a produção agrícola e são responsáveis por 35% de todos os agrotóxicos aplicados anualmente. Após a aplicação, os herbicidas podem permanecer no solo como resíduos perigosos. O mesotrione (2 - [ 4 - metilsulfonil - 2 - nitrobenzoil ] 1,3- cyclohenanedione ) é o ingrediente ativo de Callisto, um herbicida utilizado no milho . Pantoea ananatis CCT 7673, é uma enterobactéria isolada de água e foi previamente caracterizada como linhagem degradadora do mesotrione. Os objetivos deste trabalho foram o avaliar a influência do mesotrione e Callisto como agentes indutores de estresse oxidativo para o metabolismo celular de Pantoea ananatis CCT7673, bem como identificar possíveis mecanismos de tolerância a estes herbicidas. As atividades enzimáticas de SOD, CAT e GR foram avaliadas em PAGE não desnaturante e de CAT, GR e GST em espectrofotômetro. Além disto, as taxas de malondialdeído (MDA), radical superóxido e peróxido de hidrogênio (H2O2) foram medidas em espectrofotômetro. Todas as análises foram realizadas antes e após a degradação do mesotrione. Meio mínimo sem herbicida (MM) foi utilizado como controle. O herbicida provou ser agente causal do estresse oxidativo pelos dados de peróxido de hidrogênio. Inesperadamente, as taxas de MDA e GR mostraram-se inferiores nos tratamentos com herbicida em relação ao controle, sem alteração no crecimento bacteriano. A atividade de glutationa-S-transferase foi maior no tratamento com mesotrione em comparação com o controle e Callisto, durante e após a degradação. Estes resultados sugerem que essa enzima pode estar relacionada com o processo de degradação do mesotrione, provavelmente por cometabolismo. As taxas de peroxidação lipídica mostraram ser menores na presença do herbicida em comparação com o controle, sem mudanças na taxa de crescimento Quando exposta ao herbicida, P. ananatis CCT 7673 apresentou alterações na saturação de lipídios de membrana. Estas mudanças podem interferir na entrada do herbicida na célula. Tais características podem estar associadas a um nível de plasticidade fenotípica em P. ananatis CCT 7673, tornando essa bactéria um modelo interessante para estudos de tolerância a herbicidas e evolução de microbiotas em ambientes submetidos a diferentes graus de pressão seletiva.
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Sergeeva, Oksana A. "Assembly and substrate recognition properties of human CCT subunits of the TRiC chaperonin". Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/92595.
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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2014.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis. "September 2014." Vita. Page 214 blank.
Includes bibliographical references (pages 162-181).
Group II chaperonins are large multi-subunit complexes that fold cytosolic proteins to their native structures. They are composed of two back-to-back rings of 7-9 subunits. The eukaryotic cytosolic type II chaperonin Tailless Complex Polypeptide-1 (TCP-1) Ring Complex (TRiC) consists of eight different subunits identified as Chaperonin Containing TCP-1 (CCT) [alpha] (1) - [theta] (8). TRiC is necessary for folding about 10% of newly synthesized proteins and is essential for folding actin and tubulin. Most of the research on TRiC in the last 20 years has focused on yeast and bovine TRiC. However, recently, there has been inquiry into TRiC as a target for disease therapy for Huntington's disease, cataract, and some cancers. Consequently, to understand human TRiC, we purified endogenous TRiC from HeLa cells for characterization. These complexes contained all eight of the CCT subunits as determined by immunoblot. The structures were well organized as double-rings of eight subunits each, using negative stain electron microscopy (EM). Human TRiC was active in suppressing aggregation and refolding two different substrates: luciferase (a model substrate) and human [gamma]D-crystallin (H[gamma]D-Crys; a physiological substrate found in the eye lens). To further understand human TRiC, we expressed all of the human CCT subunits, one at a time in E. coli. This was done so that the subunit specificities of the CCT subunits could be studied and so we could have a system where these proteins could be genetically manipulated. Theoretically, all eight subunits in the mature TRiC-complex are needed to successfully recognize all substrates that need to be folded in the cell. We found that two CCT subunits, CCT4 and CCT5, but not the others, formed TRiC-like homo-oligomeric rings in the absence of the other CCT subunits. Purification of these complexes and subsequent structural assays by negative stain and cryo-EM showed that they formed double rings of eight subunits per ring. Biochemically, we found that CCT4 and CCT5 hydrolyzed ATP at the same rate as human TRiC, could refold luciferase to the same level as human TRiC, and suppressed aggregation of H[gamma]D-Crys. The homo-oligomeric complexes also assisted the refolding of H[gamma]D-Crys, a property not observed in the lens specific [alpha]-crystallin chaperone. On the substrates studied, CCT4 and CCT5 homo-oligomers worked as efficiently as hetero-oligomeric TRiC. More stringent substrates such as actin and tubulin need to be studied to further understand CCT specificity. Two mutations, one in CCT4 (C450Y) and one in CCT5 (H147R), have been implicated in hereditary sensory neuropathy. In order to study the defective mutant proteins, we introduced these mutations into the CCT4 and CCT5 constructs. We found that for CCT4, the newly translated mutant polypeptide chains aggregated much more than wild-type (WT) CCT4. While the mutant formed some rings in the E. coli lysate, as assayed by sucrose ultracentrifugation gradients and negative stain EM, they were not stable throughout the purification and the final purified sample contained few homo-oligomers. The mutant CCT5 polypeptide chains were properly folded and assembled in homo-oligomers. H147R CCT5 was able to hydrolyze ATP at a similar rate as WT CCT5. However, in the H[gamma]D-Crys aggregation suppression and refolding assay, mutant huntingtin aggregation suppression assay, and actin refolding assay, mutant CCT5 was not as efficient in suppression or refolding as WT CCT5. Therefore, the H147R mutation in CCT5 led to a chaperoning defect while the C450Y mutation in CCT4 led to a folding/stability defect. In order to understand features of partially folded intermediates that group II chaperonins recognize in a substrate, we investigated whether the archaeal group II chaperonin from Methanococcus maripaludis (Mm-Cpn) could recognize a variety of H[gamma]D-Crys mutants. These mutations were in regions of the protein that could act as recognition signals of substrate - unpaired aromatics, domain interface, and buried core residues. We found that Mm-Cpn was able to recognize all of these mutants, better than it recognized WT H[gamma]D-Crys. In addition, Mm-Cpn could refold most of the mutants to levels higher than WT H[gamma]D-Crys. Therefore, we concluded that Mm-Cpn doesn't recognize any of the proposed recognition signals but recognizes some [beta]-sheet interface exposed in these mutants. These studies further our knowledge of group II chaperonins and specifically human TRiC, and open up some new avenues for the investigation of the folding, assembly and function of this eukaryotic protein essential for the reproduction of all cells.
by Oksana A. Sergeeva.
Ph. D.
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Campos, Breno Barcellos. "Produção de etanol em biomassa de capim-elefante por Kluyveromyces marxianus CCT 7735". Universidade Federal de Viçosa, 2015. http://www.locus.ufv.br/handle/123456789/8471.
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O capim-elefante é uma gramínea de elevada produtividade, que apresenta grande potencial para ser utilizado como biomassa lignocelulósica para a produção de etanol de segunda geração. A levedura Kluyveromyces marxianus vem se destacando na produção de etanol celulósico em processos de sacarificação e fermentação simultâneas (SSF) por ser termotolerante, além de produzir outros metabólitos de interesse industrial. Neste contexto, o objetivo deste trabalho foi estabelecer as condições ótimas de produção de etanol por Kluyveromyces marxianus CCT 7735 por meio do processo SSF. O capim- elefante foi pré-tratado com ácido diluído e com solução alcalina e, em seguida, o resíduo celulósico obtido foi submetido a uma pré-sacarificação durante 72 horas, seguido por 120 horas de SSF. Foram avaliados o efeito de cinco variáveis: temperatura, pH, agitação, concentrações de enzimas e de resíduo celulósico de capim-elefante (biomassa) durante 120 horas de SSF. Os resultados mostraram que a levedura termotolerante K. marxianus CCT 7735 produziu etanol nos tratamentos realizados a 45 °C, temperatura próxima à ótima para a atividade das enzimas celulolíticas. A concentração de biomassa, temperatura e concentração do complexo enzimático tiveram efeito significativo (p valor < 0,05) no processo. A maior concentração de etanol, 45,3 g/L foi obtida com base nas condições sugeridas pelo modelo estatístico proposto. Essas condições foram temperatura de 38 °C, 16% (p/v) de resíduo celulósico de capim- elefante, 22,5 FPU do complexo enzimático Celluclast ® 1.5L/g de resíduo celulósico, agitação de 50 rpm e valor de pH de 4,8.
The elephant grass is a grass high productivity that has great potential to be used as lignocellulosic biomass for second generation ethanol. The yeast Kluyveromyces marxianus has been outstanding in the production of cellulosic ethanol in simultaneous saccharification and fermentation process (SSF) to be thermotolerant, as well as producing other metabolites of industrial interest. In this context, the aim of this study was to establish the optimal conditions of ethanol production by Kluyveromyces marxianus CCT 7735 through the SSF process. The elephant grass was pretreated with dilute acid and alkaline solution, then, the obtained cellulosic residue was subjected to a pre-saccharification for 72 hours, followed by 120 hours of SSF. We evaluated the effect of five variables: temperature, pH, agitation, concentrations of enzymes and cellulosic residue of elephant grass (biomass) for 120 hours of SSF. The results showed that the thermotolerant yeast K. marxianus CCT 7735 produced ethanol in the treatments performed at 45 °C, the optimum temperature for the activity of cellulolytic enzymes. The biomass concentration, temperature and concentration of enzyme complex had a significant effect (p-value < 0.05) in the process. The highest concentration of ethanol, 45.3 g/L was obtained based on the conditions suggested by the statistical model proposed. These conditions were temperature 38 °C, 16% (w/v) cellulose residue elephant grass, 22.5 FPU enzyme complex Celluclast ® 1.5L/g cellulose residue, agitation of 50 rpm, and pH of 4.8.
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Cedergren, Linda. "Expression of recombinant protein including an His-tag to facilitate purification for diagnosis of CCHF and Lassa Viruses". Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7064.
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Abstract
Crimean-Congo Hemorrhagic Fever virus (CCHF) and Lassa virus are giving sources illness to humans. In addition to zoonotic transmission, CCHF and Lassa virus can spread from person to person. After a short incubation period, CCHF and Lassa virus infections are characterized by a sudden onset of high fever, chills, headache and cough just like flu. Even some people are vomiting and have diarrhoea. After a few days of illness hemorrhagic manifestations occur. Treatment options for CCHF and Lassa viruses are limited, and there is no vaccine available for use in humans. The purpose of the present study was to produce recombinant nucleocapsid protein of Lassavirus and CCHF virus including an aminoterminal His-tag by a Semliki Forest Virus Replicon (pSFV 4.2). The recombinant proteins are planned to be used in future development of diagnostic methods.
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Rivero, Thiago Strahler [UNIFESP]. "Análise do desempenho dos índices do Conners´ Continuous Performance Test (CCPT) em uma amostra de adolescentes com TDAH". Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/8925.
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Previous issue date: 2010-02-24Introdução: O Transtorno do Déficit de Atenção e Hiperatividade (TDAH) é um transtorno neuropsiquiátrico de início precoce que afeta diversos domínios cognitivos, no entanto estudos que investigam na adolescência como o transtorno afeta esses domínios ainda são escassos. Objetivo: O presente estudo investigou o desempenho de uma amostra clínica de adolescentes com TDAH no Conners` Continuous Performance Test (CCPT). Métodos: 28 sujeitos com TDAH (17 masculino) de idade entre 12 e 18 anos participaram do estudo. Análises estatísticas das 15 medidas do CCPT foram realizadas entre o grupo TDAH e controle, além da análise fatorial proposta por Egeland e Kovalick-Gran (2009) entre os subtipos TDAH combinado (n=15) e TDAH desatento (n=13), nas quais as 15 medidas são reduzidas a 5 fatores: atenção focada, hiperatividade/impulsividade, atenção sustentada, vigilância e mudança no controle. Foi realizada ainda uma análise de correlação entre os 5 fatores e medidas cognitivas de memória operacional, função executiva, praxia visuo-construtiva, QI, entre outras. Resultados: O grupo TDAH apresentou déficit em treze das quinze medidas avaliadas pelo CCPT quando comparado ao grupo controle. Na avaliação dos cinco fatores, ambos os subtipos de TDAH apresentaram prejuízos em atenção focada, sustentada e vigilância quando comparados ao grupo controle. Não houve diferenças estatísticas entre os subtipos de TDAH em nenhum dos fatores. Foram encontradas correlações significativas entre medidas cognitivas de memória operacional visuo-espacial, visuo-construção e comportamento aferido pelo professor em todos os cinco fatores. Conclusões: A análise das 15 medidas no grupo TDAH corroborou estudos anteriores. Já a análise dos cinco fatores, proposta recente da literatura, mostrou relevância quanto à diferenciação entre grupo clínico e controle, entretanto sem resultados significativos para dissociação entre subtipos combinado e desatento.
TEDE
BV UNIFESP: Teses e dissertações
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Schmidt, D. R., i L. M. Ziurys. "New Identifications of the CCH Radical in Planetary Nebulae: A Connection to C-60?" IOP PUBLISHING LTD, 2017. http://hdl.handle.net/10150/626258.
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New detections of CCH have been made toward nine planetary nebulae (PNe), including K4-47, K3-58, K3-17, M3-28, and M4-14. Measurements of the N = 1 -> 0 and N = 3 -> 2 transitions of this radical near 87 and 262 GHz were carried out using the new 12 m and the Sub-Millimeter Telescope (SMT) of the Arizona Radio Observatory (ARO). The presence of fine and/or hyperfine structure in the spectra aided in the identification. CCH was not observed in two PNe which are sources of C-60. The planetary nebulae with positive detections represent a wide range of ages and morphologies, and all had previously been observed in HCN and HNC. Column densities for CCH in the PNe, determined from radiative transfer modeling, were N-tot(CCH) similar to 0.2-3.3 x 10(15) cm(-2), corresponding to fractional abundances with respect to H-2 of f similar to 0.2-47 x 10(-7). The abundance of CCH was found to not vary significantly with kinematic age across a time span of similar to 10,000 years, in contrast to predictions of chemical models. CCH appears to be a fairly common constituent of PNe that are carbon-rich, and its distribution may anti-correlate with that of C-60. These results suggest that CCH may be a product of C-60 photodestruction, which is known to create C-2 units. The molecule may subsequently survive the PN stage and populate diffuse clouds. The distinct, double-horned line profiles for CCH observed in K3-45 and M3-28 indicate the possible presence of a bipolar flow oriented at least partially toward the line of sight.
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Fonseca, Cristiane Sampaio. "Efeito hipolipidêmico e toxicológico do arroz fermentado por Monascus ruber , CCT 1236, em coelhos". Universidade Federal de Viçosa, 2002. http://www.locus.ufv.br/handle/123456789/8759.
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Produtos fermentados por fungos, em especial o “ang-kak” (arroz fermentado por fungos do gênero Monascus) são tradicionalmente usados na culinária asiática como corantes e condimentos. Estes fungos produzem uma substância denominada mevinolina, utilizada na redução da concentração do colesterol sérico. Essa substância inibe a enzima hidroximetilglutaril coenzima A redutase (HMG-CoA redutase), enzima chave na biossíntese do colesterol. Foi realizada a caracterização do arroz fermentado analisando as concentrações de proteínas, lipídios, carboidratos, cinzas e umidade. Posteriormente, foram realizados dois ensaios biológicos com o objetivo de avaliar os efeitos hipolipidêmicos e toxicológicos do arroz fermentado pelo fungo Monascus ruber. Utilizaram-se 36 coelhos machos da raça Nova Zelândia Branco, com hiperlipidemia induzida por colesterol 1% administrado na ração juntamente com o arroz fermentado que foi seco e triturado e adicionado nas concentrações de 1, 5 e 10%. Da análise do arroz fermentado verificou-se que houve um aumento nas concentrações de proteínas, lipídios e redução na concentração de carboidratos. O arroz fermentado na concentração de 10% foi mais eficaz no controle da hiperlipidemia, promovendo redução de colesterol total (37,14%), LDL-c (37,73%), VLDL-c (51,44%), triacilgliceróis (51,44%). O arroz fermentado a 10% promoveu aumento da lipoproteína HDL em 33,85% . O segundo ensaio foi realizado com a finalidade de avaliar a toxicologia aguda deste produto. Foram dosados as concentrações de creatinina, proteínas totais, albumina, bilirrubina total, bilirrubina direta, ácido úrico, fosfato, ferro, cloro, cálcio, e as atividades de gama glutamil-transferase (gama-GT), transaminase glutâmico- pirúvica (TGP), transaminase glutâmico-oxaloacética (TGO) e fosfatase alcalina no 1 o , 15 o , 30 o dias do experimento. No estudo toxicológico não foi observada variação significativa nos parâmetros bioquímicos analisados. No estudo histopatológico constatou-se que a adição de arroz fermentado na dieta dos animais não alterou a morfologia das células do coração. Quando adicionou-se o arroz fermentado juntamente com o colesterol, verificou-se que esse arroz impediu a formação de áreas extensas de lesões decorrentes da adição de colesterol. Quanto ao fígado, devido às características inerentes desse órgão em coelhos, o efeito da adição do arroz fermentado na dieta dos animais não levou a resultados conclusivos. O arroz fermentado por Monascus ruber se mostrou, promissor na modulação dietética de lipídios sanguíneos, embora estudos em outros modelos animais e humanos sejam necessários para resultados mais conclusivos.
Products fermented by fungus, especially the “ang-kak” (fermented rice by fungus of gender Monascus) are used traditionally in the Asian cookery as colorings and condiments. These fungus produce a substance denominated mevinoline, used in the reduction of the concentration of blood cholesterol. That substance inhibits the enzyme 3-hidroxy – 3- metilglutaryl coenzime A reductase (HMG-CoA reductase), the principal enzyme in the biosynthesis of cholesterol. The characterization of the fermented rice was accomplished investigating concentrations of proteins, fat, carbohydrates, ash and moisture. Biological assays were carried out with the objective of evaluating the hypolipidemic and toxicological effects of fermented rice by fungus Monascus ruber. Thirty six male rabbits of New Zealand White strain were used, with hyperlipidemia induced by 1% cholesterol administered in the animals feed, together with the fermented rice that was dryed and triturated and added in the concentrations of 1, 5 and 10%. It was verified an increase in the concentrations of proteins, fat and reduction in the carbohydrates concentration. The rice fermented in the concentration of 10% was more effective in the control of the hyperlipidemia, lowering total cholesterol by 37,14%, LDL-c 37,73%, VLDL-c 51,44% and triglycerides 51,44%. The 10% fermented rice promoted an increase of 33,85% on the level of HDL-c. The second assay was accomplished with the purpose of evaluating the sharp toxicological of this product on the levels of creatinine, total proteins, albumin, total bilirubin, direct bilirubin, uric acid, phosphate, iron, chlorine, calcium, glutamil gamma transferase (gama-GT), alanine aminotransferase (GPT), aspartate aminotransferase (GOT) and alkaline fosfatase in the 1 st , 15 th and 30 th days of the experiment. For the constituents any significant variation was not observed. Heart histopathology showed that the addition of fermented rice in the diet of the animals didn't alter the morphology of the its cells. When the rice was added fermented together with the cholesterol, it was verified that that rice reduced the lesions promoted by cholesterol addition. In relation to the liver, due to the inherent characteristics of that organ of the rabbits, the effect of the addition of the fermented rice in the diet of the animals was not conclusive. The fermented rice with Monascus ruber was shown in that study to be an alternative choice in the dietary modulation of blood lipids
Dissertação copiada do Alexandria
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Santos, Ademir dos. "Evid?ncias de validade do question?rio de relacionamento central (CRQ) com universit?rios". Pontif?cia Universidade Cat?lica de Campinas, 2011. http://tede.bibliotecadigital.puc-campinas.edu.br:8080/jspui/handle/tede/433.
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Previous issue date: 2011-02-15The Central Relationship Questionnaire (CRQ) is a measure consisted of self-report developed to diagnose conflictual romantic relationship according to three components: Desire (D), Response from Other (RO) and Response of Self (RS). The Core Conflictual Relationship Theme (CCRT) is its theoretical reference that allows a clinical evaluation of interpersonal conflict recurrent pat-terns.This study aimed to obtain CRQ validity evaluation among undergra-duates.The sample was composed of 509 students of several courses from three Brazilian states and the participants ages range from 17 to 59 years (M = 24,75%, F = 73,28%).CRQ consists of 101 items; 20 Wishes items, 40 Re-sponse of Others items and 38 Response of Self items. The responses are rated on a 7-point scale Likert ranging from 1 (never occurred) to 7 (always oc-curred). The items are preceded by six questions that can identify some rela-tionship characteristics as : proximity degree, intimacy, figure of authority and importance. CRQ tests when the romantic relationship was at its best and its worst moments. Data was collective inside the classroom. Analysis of correla-tion and comparison of means by test t and ANOVA indicated some differences between men and women. Regarding CRQ items, the analysis of consistency shows high alpha coefficients: D = 0,87, RO = 0,83, RE = 0,82. The factorial analysis pointed three factor solution, the first factor was represented by RE items, the second by D items and the third was composed by items of the three original factors. A theoretical interpretation for this factor suggests that it refers to the Control on the Relationship (CR). A Portuguese version of CRQ was composed of 20 RE items, 19 D and 15 CR items. Research with samples from other population classes and other country regions are indicated.
O Question?rio de Relacionamento Central - CRQ ? um instrumento de auto-relato desenvolvido para diagnosticar relacionamento amoroso conflituoso, segundo tr?s componentes: Desejo (D), Resposta do Outro (RO) e Resposta do Eu (RE). Tem como referencial te?rico o Tema Central de Relacionamento Conflituoso (CCRT), que permite uma avalia??o cl?nica dos padr?es recorren-tes de conflito interpessoal. O estudo teve como objetivo obter evid?ncias de validade do CRQ, junto a universit?rios. A amostra ficou composta por 509 es-tudantes (M = 24,75%, F= 73,28%), de tr?s estados brasileiro, de diversos cursos e idades variando entre 17 e 59 anos. O CRQ ? composto por 101 i-tens, sendo 20 para o componente Desejo, 40 para Resposta do Outro e 38 para Resposta do Eu. As respostas s?o dadas em escala Likert, variando en-tre 1 (Nunca ocorreu) e 7 pontos. (Sempre Ocorre). Antecedendo os itens, seis quest?es permitem identificar algumas caracter?sticas do relacionamento, tais como: grau de proximidade, intimidade, figura de autoridade, import?ncia, quanto foi agrad?vel nos melhores momentos e dif?cil nos piores momentos do relacionamento. A coleta de dados foi coletiva em sala de aula. Em rela??o ?s seis quest?es que identificam as caracter?sticas do relacionamento a com-para??o das m?dias por meio de testes t e ANOVA, al?m de an?lises de cor-respond?ncia que permitiram identificar algumas diferen?as entre homens e mulheres. Em rela??o aos itens do CRQ, a an?lise de consist?ncia revelou coeficientes alfa altos: D=0,87,RO=0,83, RE=0,82. A an?lise fatorial apontou para solu??o de tr?s fatores, em que o primeiro fator ficou representado por itens do componente RE, o segundo por itens do componente D e o terceiro fator ficou constitu?do por itens dos tr?s fatores originais. Uma interpreta??o te?rica para este fator sugere que ele se refere ao Controle no Relacionamen-to (CR). A vers?o em portugu?s do CRQ ficou constitu?da por 20 itens de RE, 19 de D e 15 de CR. Pesquisas com amostras de outros estratos da popula-??o e de outras regi?es do pais s?o indicadas.
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Casarin, Samuel Jose. "Caracterização da temperabilidade de um aço C-Mn microligado ao boro, através de dilatometria e curvas de transformações de fases por resfriamento contínuo". Universidade de São Paulo, 1996. http://www.teses.usp.br/teses/disponiveis/88/88131/tde-29012010-160947/.
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No presente trabalho, foi realizado um estudo sobre a influência da adição do boro em um aço C-Mn, nas transformações de fases por resfriamento contínuo, através da técnica dilatométrica. Para este estudo, utilizou-se dois aços de composição química semelhante: o aço 10B22 com 30 ppm de boro e o aço sem boro é o E1522, equivalente. Foram traçadas as curvas de CCT dos dois aços, onde analisou-se o efeito de temperabilidade do boro através das curvas de resfriamento. Os materiais foram ensaiados em um dilatômetro de resfriamento rápido, utilizando corpos de prova cilíndricos, resfriados por injeção de ar e hélio. Os resultados gráficos dos processos de resfriamento foram comparados com análises metalográficas ótica estruturais e quantitativas e também por medidas de dureza. Detalhes microestruturais, tais como, contagem de fases formadas em função das taxas de resfriamento, tamanho de grão, distribuição de inclusões e precipitados, foram extraídos, através de um sistema de análise de imagens. Complementando o trabalho, foi realizado uma completa documentação fotográfica das microestruturas, com uma indicação final do tratamento térmico mais adequado aos aços C-Mn microligados ao boro.This work presents a study about the influence of boron on phase transformation by continuous cooling in a C-Mn steel using the dilatometric technique. For this study two close chemical composition steels were applied: a 10B2 steel with 30 ppm of boron and a E1522 steel without boron. For both steels the CCT curves were obtained, where the effect of boron on hardenability was analysed throughout continuous cooling curves. Both materials were testedcin a high speed quenching dilatometer, using cilindricals samples quenched by helium blow on their surfaces. The graphics results of cooling processes were compared with microstructural and quantitative optical metallographic analysis and hardness measurements. Microstructural features as such phases fraction as a function of cooling rates, grain size, and distributions of inclusions and precipitates were obtained through an image analysis system. In addition, complete microstructural photography documentation was carried out where it was possible to indicate the best heat treatment to boron microalloyed C-Mn steels.
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Domokos-Bays, Becky L. "The Role Of The Citizen's Clearinghouse For Hazardous Wastes As An Agent Of Adult Education In The Environmental Justice Movement From 1981-1985". Diss., Virginia Tech, 1997. http://hdl.handle.net/10919/29867.
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This historical study examined the educational dimensions of the Citizen's Clearinghouse for Hazardous Wastes from 1981-1995. Its role as an agent of adult education in the grassroots movement for environmental justice was demonstrated by tracing the movement from the toxic waste disaster at Love Canal, New York and focusing on the role of Lois Gibbs as a leader in the movement. The conceptual framework for the study was built upon interdisciplinary work in the fields of adult education, sociology, and educational history. The study examined the mission, belief systems, processes and strategies of learning and information dissemination by the Clearinghouse during three periods: 1981-1986, during which the organization was formed and began to develop a mission and belief system; the 1987-1991 period when CCHW experienced enormous growth and began to exert its power nationally with campaigns such as the McToxics Campaign. It was also during this period that CCHW began the process of working toward a unified grassroots environmental justice movement; and the period from 1992-1995 which marked the beginning of CCHW's second decade of existence and in which CCHW conducted an in-depth organizational assessment. Organizing and technical assistance were found to be the primary vehicles of learning. Publications and site visits were powerful dissemination mechanisms used to assist citizens in their struggles against corporations and government authorities. Secondly, citizens who remained active in the environmental justice movement often took on broader roles such as organizing regional citizen groups. The study found that women composed nearly eighty percent of the leaders in the movement. Reasons for involvement varied, but most women became involved initially out of fear for theirs or a loved one's health. Conclusions drawn indicate that learning occurred through everyday experiences and empowered citizens to take direct action in their communities. Secondly CCHW emerged as a powerful national political force due to its ability to maintain its mission of continuously listening and meeting the needs of its grassroots constituents.Ph. D.
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Münchow, Gabriel Bonow. "Impacto da assimilação de dados de aerossóis no modelo ambiental CCAT-BRAMS: um estudo de caso da campanha CLAIM". Instituto Nacional de Pesquisas Espaciais, 2011. http://urlib.net/sid.inpe.br/mtc-m19/2011/02.03.12.46.
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Todos os anos no Brasil central, grandes áreas de floresta, cerrado e pasto são queimadas, emitindo aerossóis de carbono primário para a atmosfera, especialmente no final da estação seca. Os aerossóis interferem no balanço de radiação, afetando diretamente a quantidade de radiação refletida e retroespalhada de volta ao espaço, a radiação absorvida pela atmosfera, e também a radiação de onda longa. Além dos efeitos diretos, os aerossóis afetam a microfísica de nuvens, agindo como núcleos de condensação, modificando o regime de precipitação e o albedo da nuvem. Durante a estação de queima na América do Sul, a qualidade do ar também é significativamente afetada pelos aerossóis, diminuindo a visibilidade e causando doenças respiratórias devido às partículas inaláveis. Modelos numéricos de transporte químico da atmosfera podem ser usados para estudar e prever o comportamento dos aerossóis e seus efeitos. As simulações feitas por estes modelos podem obter melhores resultados através de métodos de assimilação de dados, utilizando observações disponíveis para corrigir as simulações do modelo. Neste estudo, foi utilizado um sistema de assimilação baseado no método variacional em duas dimensões (2D-Var), acoplado ao modelo \textit{Coupled Chemical-Aerosol-Tracer Transport - Brazilian developments on the Regional Modeling System} (CCATT-BRAMS). O sistema 2D-Var foi utilizado para assimilar observações de concentração de massa de material particulado menor que 2,5$\mu$m (PM$_{2.5}$). Estas observações foram coletadas durante a campanha \textit{Cloud-Aerosol Interaction Measurements} (CLAIM), realizada em outubro de 2007, na região norte do Estado do Mato Grosso, Brasil. As medidas foram realizadas utilizando o instrumento DataRAM abordo de uma aeronave que coletou informações com uma freqüência de 10 segundos e 30 segundos. Durante a campanha, foram realizados 17 vôos ao todo, dos quais 13 puderam ser utilizados neste estudo. Os resultados apresentam uma considerável melhora nos valores de PM$_{2.5}$ modelados, aproximando o modelo das observações, mesmo assimilando uma observação média por vôo. Os melhores resultados foram obtidos com a utilização do Erro Relativo de \textit{Background} igual a 200\%, com um fator de correção calculado pela assimilação adaptado ao tipo de observações assimiladas, com raios de influência inomogêneos, calculados individualmente para cada vôo, e com um banco de dados observados suavizados, sem picos singulares de concentração. Com estas configurações o sistema de assimilação foi capaz de aproximar de maneira ótima as análises às observações.In Central Brazil every year large areas of forest, cerrado and pasture land are bumed emitting primary carbonaceous aerosols into the atmosphere, especially in the end of the dry season. The aerosols interfere with the radiative budget, affecting directly the amount of solar radiation that is reflected and scattered back to space, and partly absorbed by the atmosphere. The long wave terrestrial radiation is also affected. Aerosols also affect cloud microphysics acting as cloud condensation nuclei (CCN), modifying precipitation patterns and cloud albedo. During the South American burning season, aerosols have a significant impact on local and regional air quality affecting visibility and human health by particle inhalation causing pulmonary diseases. Atmospheric chemical numerical models can be used to study and forecast aerosol behavior and effects. Better simulations of aerosols by numerical models can be achieved through data assimilation methods including available aerosol observations to correct the model simulations. In this study an assimilation system was used based on a two dimensional variational data assimilation method (2D- VAR) coupled to the Coupled Chemical-Aerosol-Tracer Transport - Brazilian developments on the Regional Modeling System (CCATT-BRAMS). The assimilated observations are mass concentration (MC) of particular matter smaller than 2,5$\mu$m (PM$_{2.5}$). The observations were collected in October 2007, during the Cloud-\textit{Aeroso}l Interaction Measurements (CLAIM) campaign, which took place in the northern region of the state of Mato Grosso, Brazil. The measurements of PM$_{2.5}$were collected by a DataRAM instrument aboard the aircraft that collected information with a frequency of 10s or 30s. During the campaign 17 flights were carried out, 13 of which could be used in this study. The assimilation system shows a considerable improvement of the modeled PM$_{2.5}$ field, approaching its values to the observations, as expected, even assimilating an average observation for each flight. The best guess was obtained using the Relative Background Error equal to 200\%, the correction factor calculated by assimilation system adapted to the kind of assimilated observations, inhomogeneous radii of influence, and smoothed observational data without outliers. With these parameters the assimilation system was able to approach, in a optimal way, the analysis to the observations.
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CARDANI, SILVIA. "NEWLY IDENTIFIED PHOX2B-REGULATED GENES AS POSSIBLE DRUG TARGETS FOR THE PHARMACOLOGICAL INTERVENTION IN CONGENITAL CENTRAL HYPOVENTILATION SYNDROME (CCHS)". Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/610106.
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Congenital Central Hypoventilation Syndrome (CCHS, OMIM #209880) is a very rare neonatal neurological disorder characterized by a broad variety of symptoms of autonomic nervous system dysfunction including inadequate control of breathing (Weese-Mayer et al., 2017). It is often associated with Hirschsprung’s disease (HSCR) and neural crest-derived tumours (i.e. neuroblastoma). Frameshift mutations (5%) and polyalanine triplet expansions (from 4 to 13 residues) (95%) have been detected in the coding region of PHOX2B, a transcription factor required for the development of neurons that regulate the cardiovascular, respiratory and digestive organs, forming the sensory and motor arms of the visceral reflex circuits. Consistent with its role as transcriptional regulator, transcriptional dysregulation might be an important mechanism of CCHS pathogenesis. CCHS is a life-long disorder for which the only treatment option is ventilatory support provided by tracheotomy, nasal mask or diaphragm pacing by phrenic nerve stimulation, as pharmacological respiratory stimulants have proved to be ineffective. A strong limitation to the comprehension of the pathogenesis of CCHS, and the development of new and effective treatment for this disease, is the missing knowledge of target genes regulated by PHOX2B, whose expression may be eventually dysregulated. Very little is known about the genes regulated by PHOX2B. Most of the genes identified so far are regulatory genes that encode for transcription factors and enzymes that control downstream processes involved in the survival and differentiation of specific neural structures, such as TH, DBH (Lo et al., 1999; Adachi et al., 2000), PHOX2A (Flora et al., 2001), TLX2 (Borghini et al.,2006), RET (Bachetti et al., 2005) MSX-1 (Revet et al., 2008), SOX10 (Nagashimada et al., 2012), ALK (Bachetti et al., 2010) and PHOX2B itself (Cargin et al., 2005).
The aim of this thesis was to identify new potential pharmacological targets for the development of drugs in order to improve the respiratory symptoms and the quality of life of CCHS patients.
In the first part of my project we investigated the molecular mechanisms underlying the recovery of chemosensitivity, observed in two CCHS patients, following the administration of the progestinic desogestrel (Straus et al., 2010). In SK-N-BE(2)C cell clones, stably expressing nuclear progesterone receptor isoforms PR-B and PR-A, we demonstrated that 3-KDG treatment, active metabolite of the desogestrel, reduces the expression of PHOX2B, its target genes as well as PHOX2B +7 alanine expanded protein, by means of a post-transcriptional mechanism. This finding provided the evidence of a direct molecular link between PHOX2B and desogestrel and suggested the possibility that reduction of PHOX2B mutant protein may contribute to the positive effects observed in the two CCHS patients.
In the second part of my project we proposed to identify new PHOX2B target genes that can be deregulated in the pathology, in the future perspective that might be potential pharmacological targets, alternative to PHOX2B. In particular, we demonstrated that transcriptional dysregulation and dysfunctions of K+ and Na+ channels activity may contribute to the onset of respiratory problems associated with CCHS. Target directly the de-regulated PHOX2B target genes is an alternative pharmacological strategy to by-pass the effect on PHOX2B in the perspective of rescuing their activity. Since several drugs targeting these proteins are already used in clinics, the potential progress toward a therapeutic intervention to treat CCHS is today more than concrete.
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Azevedo, Fernanda Marques de. "Avalia??o do potencial anti-inflamat?rio de composto tipo heparina (cCTH) extra?do do caranguejo Goniopsis cruentata em modelo experimental de peritonite". Universidade Federal do Rio Grande do Norte, 2013. http://repositorio.ufrn.br:8080/jspui/handle/123456789/12609.
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Previous issue date: 2013-03-01Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior
Heparin, a sulfated polysaccharide, was the first compound used as an anticoagulant and antithrombotic agent. Due to their structural characteristics, also has great potential anti-inflammatory, though such use is limited in inflammation because of their marked effects on coagulation. The occurrence of heparin-like compounds that exhibit anticoagulant activity decreased in aquatic invertebrates, such as crab Goniopsis cruentata, sparked interest for the study of such compounds as anti-inflammatory drugs. Therefore, the objective of this study was to evaluate the potential modulator of heparin-like compound extracted from Goniopsis cruentata in inflammatory events, coagulation, and to evaluate some aspects of its structure. The heparin-type compound had a high degree of N-sulphation in its structure, being able to reduce leukocyte migration into the peritoneal cavity at lower doses compared to heparin and diclofenac sodium (anti-inflammatory commercial). Furthermore, it was also able to inhibit the production of nitric oxide and tumor necrosis factor alpha by activated macrophages, inhibited the activation of the enzyme neutrophil elastase in low concentrations and showed a lower anticoagulant effect in high doses as compared to porcine mucosal heparin. Because of these observations, the compound extracted from crab Goniopsis cruentata can be used as a structural model for future anti-inflammatory agents
A heparina, um polissacar?deo sulfatado, foi o primeiro composto utilizado como anticoagulante e agente antitromb?tico. Devido ?s suas caracter?sticas estruturais, possui ainda um grande potencial anti-inflamat?rio, entretanto tal uso na inflama??o ? limitado em raz?o de seus efeitos acentuados na coagula??o. A ocorr?ncia de compostos semelhantes ? heparina que apresentam atividade anticoagulante diminu?da em invertebrados aqu?ticos, como o caranguejo Goniopsis cruentata, despertou o interesse para o estudo de tais compostos como f?rmacos anti-inflamat?rios. Diante disso, o objetivo do presente trabalho foi avaliar o potencial modulador do composto semelhante ? heparina extra?do do Goniopsis cruentata em eventos inflamat?rios, coagula??o, al?m de avaliar alguns aspectos de sua estrutura. O composto tipo heparina apresentou alto grau de N-sulfata??o em sua estrutura, sendo capaz de reduzir a migra??o leucocit?ria para a cavidade peritoneal em doses mais baixas em rela??o ? heparina e ao diclofenaco de s?dio (anti-inflamat?rio comercial). Al?m disso, foi capaz ainda de inibir a produ??o de ?xido n?trico e fator de necrose tumoral alfa por macr?fagos ativados, inibiu a ativa??o da enzima neutrof?lica elastase em concentra??es baixas e apresentou um menor efeito anticoagulante em doses altas em compara??o com a heparina de mucosa su?na. Devido a essas observa??es, o composto extra?do do caranguejo Goniopsis cruentata pode ser utilizado como um modelo estrutural para futuros agentes anti-inflamat?rios
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Sundman, Viktor. "Conditional and Unconditional Transfers : Remittances and the take-up of CCT programs in developing countries". Thesis, Uppsala universitet, Statsvetenskapliga institutionen, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-295211.
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This study examines the relationship between reception of remittances and CCT participation. Three hypotheses, predicting a negative relationship between remittances and CCTs, are presented. These are tested by logit regressions based on data from national household surveys from four Latin American countries. The study finds some support for a negative correlation between remittances and CCT participation, but lack of data restricts the possibility of drawing firm conclusions from the study.