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Aliyev, N. N., i F. A. Heydarova. "THE STUDY OF THE ANTIMICROBIAL ACTIVITY OF SOME NEW AZO DERIVATIVES OF PYRIDOXINE AND THEIR ZINC COMPLEXES". Epidemiology and Infectious Diseases 17, nr 2 (15.04.2012): 60–62. http://dx.doi.org/10.17816/eid40678.
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For the first time with the use of conventional techniques the overall toxicity and the antimicrobial activity of some new substances - pyridoxine azo derivatives (mercurions), obtained an international registration (CAS, USA) and their zinc-complexes have been studied. St. aureus, E.coli, Pseudomonas aeruginosa, and Candia albicans were used as a test cultures. The investigated compounds were established to have low toxicity (LD 50 failed to detect, with a maximum dose of introduced animals as 0.01 g ≈ 20 g), and some of them were shown to have pronounced antimicrobial activity. In contrast to free mercurions their zinc complexes show activity against strains of some microorganisms (St. aureus, Candida albicans), as well as similar antimicrobial activity in the lower (2-4 fold) concentrations.
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Yamada, Tsuyoshi, Shigeo Shindo, Kazuyuki Otani i Osamu Nakai. "Candia albicans lumbar spondylodiscitis contiguous to infected abdominal aortic aneurysm in an intravenous drug user". BMJ Case Reports 14, nr 4 (kwiecień 2021): e241493. http://dx.doi.org/10.1136/bcr-2020-241493.
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While the incidence of spondylodiscitis is rising because of longer life expectancy and the increasing use of immunosuppressant drug, indwelling devices and spinal surgeries, the fungal aetiology remains rare, sometimes affecting intravenous drug users. Candida spondylodiscitis is an extremely rare complication post aortic aneurysm repair. It is potentially fatal due to the risk of aneurysm rupture and septic complications. The growing problem of systemic diseases caused by Candida species reflects the enormous increase of patients at risk. The treatment of this complicated entity is challenging and often requiring a multidisciplinary team. We reported the rare case of Candida spondylodiscitis contiguous to infected aortic aneurysm in a 74-year-old male intravenous drug user, to the extent which the vertebral body bony destruction progressed to need one-stage posterior and anterior spinal fusion surgery with curettage. Our surgical intervention combined with prolonged course of antifungal therapy could successfully eradicate the infection and resolve the neurological deficits.
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Harsini, H. "Pengaruh Ekstrak Etanolik Kulit Batang Jambu Mete (Anacardium occidentale Linn) sebagai Bahan Kumur terhadap Daya Perlekatan C. Albicans pada Plat Resin Akrilik". Majalah Kedokteran Gigi Indonesia 19, nr 1 (20.10.2016): 137. http://dx.doi.org/10.22146/majkedgiind.15398.
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Latar Belakang: Candia albicans adalah mikroorganisme yang berkoloni melekat pada permukaan gigi maupun gigi tiruan. Obat kumur mengandung bahan tarapeutik yang berfungsi sebagai antibakteri. Kulit batang jambu mete antara lain mengandung senyawa fenolik yang dapat berkhasiat sebagai antibakteri. Tujuan penelitian: Untuk mengetahui apakah ekstrak etanolik kulit batang jambu mete sebagai bahan kumur berpengaruh terhadap gaya perlekatan C. Albicans pada plat resin akrilik. Metode penelitian: Ekstrak kulit batang jambu mete diperoleh dengan menggunakan metode maserasi dan menggunakan etanol sebagai pelarut. Bahan kumur ekstrak kulit batang jambu mete dibuat dengan komposisi bahan kumur standar dengan menambahkan ekstrak etanolik kulit batang jambu mete dengan konsentrasi 1%, 2%, 3%, 4%, dan 5% sebagai agen antibakteri. Penelitian dilakukan dengan menggunakan plat resin akrilik yang dibuat bentuk disk dengan ukuran diameter 10 mm dan tebal 2 mm sebanyak 24 buah, yang dibagi dalam 6 kelompok yaitu 5 kelompok perlakuan dengan menggunakan bahan kumur yang mengandung ekstrak kulit batang jambu mete dan 1 kelompok kontrol menggunakan bahan kumur standar. Seluruh plat resin dimasukkan dalam tabung C. Albicans 10 CFU/ml selama 5 menit, kemudian plat diambil dan dimasukkan dalam larutan bahan kumur standar sebagai kontrol dan larutan bahan kumur yang mengandung ekstrak kulit batang jambu mete untuk kelompok perlakuan selama 3 menit dan digetarkan. Cairan kemudian diambil sebanyak 0,1 ml dan ditanam pada piring petri dengan agar saboruraud dan diinkubasi selama 48 jam. Perhitungan koloni dilakukan menggunakan counter. Hasil penelitian: Hasil daya perlekatan pada bahan kumur standar 1912,50±14,93; pada bahan kumur dengan ekstrak 1% = 1757,50±20,16; 2% = 1335±17,08; 3% = 1220; 4% = 915±22,17 dan 5% = 670,00±38,37. Analisis varian satu jalur memperlihatkan pengaruh yang bermakna ekstrak etanolik kulit batang jambu mete terhadap daya lekat C. Albicans pada plat resin akrilik (p<0,05). Hasil LSD menunjukkan bahwa terdapat perbedaan yang bermakna antar seluruh kelompok perlakuan (p<0,05). Kesimpulan: Ekstrak etanolik kulit batang jambu mete sebagai bahan kumur berpengaruh terhadap daya perlekatan C. Albicans pada plat resin aklirik. Background: C. Albicans is a microorganism which colonized on the tooth or denture prosthesis surfaces. Mouthwashes usually contain therapeutic agent as antibacterial. The bark of Annacardium occidentale contains fenolic as antibacterial activity. The aim of this research was to determine the influence of the etanolic ectract of anacardium occidentale bark as mouthwashes on C. Albicans adherence. Method: the extract of anacardium occidentale bark was conducted in maceration method and used ethanol as solvent. Mouthwashes were made in standart composition and added annacardium occidentale bark extract 1%, 2%, 3%, 4% and 5% as antibacterial agent. As a negative control was used standart mouthwashes without extract. The research used 24 resin acrylic which made in disk shape with diameter 10 mm. This acrylic were divided in 6 group, there were 5 group treated with mouthwash that contain extract anacardium occidentale bark and 1 group treated with standart mouthwashes. All of resins plate were incubated in C. Albicans solution for 5 minute. After that resin acrylic plate were immersed in standart mouthwashes as a control and mouthwashes with anaracium occidentale bark extract and vibrate for 3 minutes. The solution then taken 0,1 ml and planted in petry dish with saboruraud agar and incubated for 48 hours. Result: Attachment of candida alvicans was: 1912,50±14,93 as control and mouthwash with extract were 1% = 1757,50±20,16; 2% = 1335±17,08; 3% = 1220; 4% = 915±22,17 and 5% = 670,00±38,37. Analyzed with one way Anova showed that the extract of annaracium occidentale bark as mouthwash influenced the cancida albicans adherence on resin acrylic surface (p<0,05). LSD analyzed showed there were significant differenced between all groups (p<0,05). Conclusion: The extract of anacardium occidentale bark extract as mouthwash were influence of the C. Albicans adherence on resin acrylic surface.
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Matsushita, Sho, Kumiko Hashimoto, Rie Takagi i Takehiro Higashi. "Curdlan induces Th17 polarization via Jagged1 activation in human dendritic cells (47.12)". Journal of Immunology 182, nr 1_Supplement (1.04.2009): 47.12. http://dx.doi.org/10.4049/jimmunol.182.supp.47.12.
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Abstract Th17-inducing activity is carried by certain polysaccharides such as ƒÀ-glucan derived from Candia albicans. Our previous studies have shown that Th1- and Th2-inducing activities can be qualitatively evaluated by the expression patterns of Notch ligand isoforms, using human monocyte-derived dendritic cells (DCs) and some leukemic cell lines. Thus, the Th1- and Th2-inducing activities correlate with the upregulation of Delta4 and Delta1 mRNA, respectively. However, the association of Th17-inducing activities with Notch ligand expression patterns has been unclear. The present study shows that curdlan, one of ƒÀ-glucans, has the ability to induce DC-mediated Th17 differentiation, by using a mixed lymphocyte reaction (MLR) between human monocyte-derived DCs and allogeneic naïve CD4+ T cells. It is also interesting to note that Jagged1 mRNA in DCs is up-regulated by curdlan. Furthermore, polyclonal anti-Jagged1 antibody inhibited such DC-mediated Th17 differentiation. These findings suggest that curdlan induces human DC-mediated Th17 polarization via Jagged1 activation in DCs.
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Hafizah, Yunita, Yuliana Salman, Risnawati Risnawati i Hajrah Hidriya. "GAMBARAN Candida albicanss PADA URIN REMAJA DI PANTI ASUHAN X BANJARMASIN". Jurnal Kajian Ilmiah Kesehatan dan Teknologi 4, nr 2 (1.11.2022): 54–60. http://dx.doi.org/10.52674/jkikt.v4i2.76.
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Candida albicans is one of the most pathogenic species and often causes vaginitis in women with the main symptom of vaginal discharge. As many as 75% of women in Indonesia have experienced vaginal discharge at least once in their life and half of them have experienced vaginal discharge twice or more. This study aims to calculate the percentage of Candida albicanss in the urine of adolescents at the Putri Orphanage in Banjarmasin. This type of research is quantitative and descriptive with a cross-sectional design. The research sample was 21 urine sample teenagers at the Orphanage in Banjarmasin. The sampling technique used was purposive sampling. Laboratory examinations included macroscopic observations of Candida colonies growing on Sabouraud Dextrose Agar (SDA) media, and microscopic observations using the Germ Tube test to distinguish Candida albicanss species from Candida non-albicanss. And by filling out a questionnaire to determine the level of knowledge about vaginal discharge and personal hygiene. The results showed 33% of respondents were positive for Candida albicanss. Based on the results, overview Candida albicans in adolescents at the Putri Asri Orphanage in Banjarmasin, it can be concluded that there are 7 samples (33%) positive for Candida albicans. Personal hygiene and environmental sanitation can affect the growth of Candida albicans which can cause vaginal discharge in adolescent girls.
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Agbedo, E. S., O. R. Osumah, E. P. Woghiren i I. P. Omusi. "Prevalence of Candida albicans Among Pregnant and Non-Pregnant Women attending a Medical Facility in Oredo, Edo State, Nigeria". Journal of Applied Sciences and Environmental Management 27, nr 1 (31.01.2023): 101–5. http://dx.doi.org/10.4314/jasem.v27i1.15.
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Candida albicans is the most prevalent cause of fungal infections worldwide as a consequence of various triggering environments. Hence, this paper evaluates the prevalence of Candida albican in the cultures of pregnant and non-pregnant women who attended prenatal classes at a medical facility in Oredo, Edo State, Nigeria by collecting200 vaginal swab samples for microbiological examination using standard methods. The pour plate method was used to carry out microbial isolation. Based on their cultural, morphological, and biochemical characteristics, isolated microorganisms were recognised. The agar dilution technique was used to test antifungal sensitivity. The results showed that the lowest fungal count was 0.6±0.48×103 cfu/g and the highest fungal count was 5.6±0.32×103 cfu/g. Both Candida albicans and non-albicans were among the fungal isolates. In comparison to non-pregnant women (18 %), pregnant women had a percentage frequency of Candida albican of 30.5 %. Age groups 31 to 35 and 41 to 46 showed the highest and lowest frequencies of Candida albicans, respectively, among the pregnant women. Additionally, the age range of 20 to 25 had the highest frequency of Candida albicans among the non-pregnant women, while the age range of 36 to 40 had the lowest frequency. No antifungal resistance was found in any of the Candida albicans isolates to the analytical grades of itraconazole or clotrimazole, respectively. Additionally, isolate proliferation was inhibited by Ocimum gratissimum extracts. This study revealed that pregnant women had a higher prevalence of Candida albicans than non-pregnant women. It is recommended that, the general public given orientation of the major health effects of vulvovaginal candidiasis during pregnancy, especially during antenatal.
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Irawan, Yogie, i Riky Riky. "UJI DAYA HAMBAT ANTIFUNGI Candida Albicans TERHADAP UMBI BAWANG PUTIH (Allium sativum) DAN DAUN SAMBILOTO (Andrographis Paniculata Nees) MENGGUNAKAN METODE CAKRAM KERTAS". Jurnal Borneo Cendekia 2, nr 1 (10.03.2018): 104–10. http://dx.doi.org/10.54411/jbc.v2i1.111.
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Telah dilakukan penelitian yang berjudul “Uji Daya Hambat Antifungi Candida albicans Terhadap Infusa Umbi Bawang Putih (Allium Sativum Linn) dan Infusa Daun Sambiloto (Andrographis P,Folium) Menggunakan Metode Cakram Kertas”. Penelitian ini bertujuan untuk mengetahui apakah kombinasi umbi bawang putih dan daun sambiloto dapat berfungsi sebagai antifungi terhadap candida albican danuntuk mengetahui pada konsentrasi berapakah penggabungan umbi bawang putih dan daun sambiloto yang efektif sebagai antifungi Candida albicans. Uji daya hambat ini dilakukan dengan menggabungkan infusa umbi bawang putih dan daun sambiloto pada konsentrasi 50%:50%, 25%:75%, 75%:25%. Metode pengujian antifungi ini adalah metode difusi agar, dengan cakram kertas. Dari hasil penelitian uji daya hambat antifungi candida albicans terhadap infus umbi bawang putih (Allium Sativum Linn) dan infus daun sambiloto (Andrographis P,Folium) dapat disimpulkan bahwa infusa umbi bawang putih (Allium Sativum Linn) dan infus daun sambiloto (Andrographis P,Folium) mampu menghambat pertumbuhan jamur candida albicans, berdasarkan hasil penelitian yang telah dilakukan bahwa konsentrasi sampel yang digunakan yang dapat menghambat jamur candida albicans adalah konsentrasi 75%:25%.Kata Kunci : bawang putih, daun sambiloto, candida albicans
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Supriyanto, Supriyanto, Kuswiyanto Kuswiyanto i Etiek Nurhayati. "Efektivitas Air Perasan Daun Lidah Buaya (Aloe Vera) Terhadap Pertumbuhan Jamur Trichophyton Rubrum Dengan Metode Dillution Test". Jurnal Laboratorium Khatulistiwa 1, nr 2 (30.04.2018): 152. http://dx.doi.org/10.30602/jlk.v1i2.155.
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Abstract: This research goals to identify the effect of inhibitory potency in Aloe vera to fungi colonies Trichophyton rubrum and Candida albicans growth. Samples was scraped Aloe vera leaves which formed into jelly, that considered as 100% concentration (v/v), jelly was made into different concentrations, e.g 10%, 15%,20%, 25%, 30%, 35%, 40%, 45%, 50%, 55% dan 60% v/v. Furthermore, it observed by the difference between those concentrations in inhibiting fungi colonies growth )Trichophyton rubrum and Candida albicans). Method used in this study was Dillution Test for identifying fungi colonies growth )Trichophyton rubrum and Candida albicans). The results reported in percentage of inhibited fungi colonies. In addition, it examined then by using Anova Test to make sure whether there was a difference or not between various concentration in inhibiting fungi colonies beefing up. Based on study, it is known that Aloe vera jelly was able to constrain fungi (Trichophyton rubrum and Candida albicans) improvement, but it could not capable to kill those fungi perfectly. Statistically, it can be seen that Aloe vera jelly was quite able to inhibit the growth of fungi colonies (Trichophyton rubrum and Candida albican) with significance value P = 0,997 (P > 0,05).Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh daya hambat jeli lidah buaya (Aloe vera) terhadap pertumbuhan koloni jamur Trichophyton rubrum dan Candida albicans. Sampel berasal dari daging daun lidah buaya yang dikerok berupa jeli, yang konsentrasinya dianggap 100%(v/v), jeli dibuat variasi konsentrasi yaitu 10%, 15%,20%, 25%, 30%, 35%, 40%, 45%, 50%, 55% dan 60% v/v). Kemudian dilihat perbedaan antara konsentrasi dalam menghambat pertumbuhan koloni jamur Trichophyton rubrum dan Candida albicans. Metode pada penelitian ini menggunakan Dillution Test terhadap pertumbuhan koloni jamur Trichophyton rubrum dan Candida albicans. Hasil penelitian berupa persentase jumlah koloni jamur yang dihambat. Kemudian dilanjutkan dengan menggunakan uji anava untuk mengetahui perbedaan antara konsentrasi perlakuan dalam menghambat pertumbuhan koloni jamur. Berdasarkan dari penelitian dapat diketahui bahwa jeli lidah buaya mampu menghambat pertumbuhan jamur Trichophyton rubrum dan Candida albicans tetapi tidak sampai membunuh dengan sempurna. Namun secara stastisik jeli lidah buaya dapat menghambat pertumbuhan koloni jamur Trichophyton rubrum dan Candida albican dengan nilai signifikansi P = 0,997 (P > 0,05).
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Wijaya, C. Hanny, A. Fieki Rachmatillah i Boy M. Bachtiar. "PENGHAMBATAN CAJUPUTS CANDY TERHADAP VIABILITAS KHAMIR Candida albicans SECARA IN VITRO [Inhibition of Cajuputs Candy Toward the Viability of Candida albicans by using In Vitro Assay]". Jurnal Teknologi dan Industri Pangan 25, nr 2 (grudzień 2014): 158–67. http://dx.doi.org/10.6066/jtip.2014.25.2.158.
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Bastian, Firna Nuha, Maria Ulva i Rossa Veronneca. "Utilization of Carbohydrates in Bamboo Shoots (Dendrocalamus asper) As an Alternative Media for the Growth of Candida albicans fungus". Sainmatika: Jurnal Ilmiah Matematika dan Ilmu Pengetahuan Alam 20, nr 1 (30.06.2023): 1–7. http://dx.doi.org/10.31851/sainmatika.v20i1.11303.
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Candidiasis disease caused by the fungus Candida albicans is a health problem in Indonesia. The chronic nature of the disease gets worse if it is accompanied by a fungal infection, which usually goes undiagnosed and untreated. Culture techniques can be used to identify the fungus Candida albicans. Mushroom culture in the laboratory requires a medium containing nutrients such as a carbohydrate source and a nitrogen source for growth. These nutrients can be found in bamboo shoots which contain high carbohydrates, protein, fat, vitamins, and crude fiber. So that bamboo shoots can be used as raw material for alternative mushroom growth media. The purpose of this study was to utilize bamboo shoots as a medium for the growth of Candida albicans herbal medicine. This research included collecting bamboo shoots, making rice bran media, inoculation of Candida albicans fungus on bamboo shoots media, and observing fungal growth. Candida albicans fungal colonies were confirmed by macroscopic and microscopic observations. The results showed that the fungus Candida albicans grew on both media, namely Bamboo Shoots Flour Media and Sabouraud Dextrose Agar (SDA) media at 37oC for 48 hours. The conclusion of this study is that bamboo shoots media can be used as a medium for fungal growth. Bamboo shoots media can be used as an alternative medium for synthetic media to grow Candida albican
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Fusco, Alessandra, Maria Contaldo, Vittoria Savio, Adone Baroni, Giuseppe A. Ferraro, Dario Di Stasio, Alberta Lucchese, Adriana Chiaromonte, Giovanna Donnarumma i Rosario Serpico. "An Unconventional Oral Candidiasis in an Immunocompetent Patient". Journal of Fungi 9, nr 3 (24.02.2023): 295. http://dx.doi.org/10.3390/jof9030295.
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Oral candidiasis (OC) is an opportunistic fungal infection of the oral mucosae, sustained by Candida albicans or other non-albican Candida species (NAC), usually eradicated by conventional antifungals of the classes of azoles, polyenes, or derivative from echinocandins. OC usually occurs under predisposing local or systemic factors. C. lusitaniae is an opportunistic strain that is rarely responsible for human infection and occurs mainly in severe immunocompromised states. The present work reported an unconventional case of OC in an otherwise healthy immunocompetent woman sustained by C. lusitaniae and a multi-resistant strain of C. albicans.
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Santoso, Toto, Sukmawati Sukmawati i Alda Miranti. "UJI EFEKTIVITAS AIR PERASAN JERUK NIPIS (Citrus aurantifolia (Christm.) Swingle)DALAM MENGHAMBAT PERTUMBUHAN JAMUR Candida albicans". HERBAPHARMA : Journal of Herb Farmacological 3, nr 2 (31.12.2021): 96–101. http://dx.doi.org/10.55093/herbapharma.v3i2.279.
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Masalah yang sering terjadi di masyarakat adalah penyakit kandidiasis yang disebabkan oleh beberapa jamur salah satunya Candida albicans. Jeruk nipis (Citrus aurantifolia (Christm.) Swingle) merupakan tanaman obat yang tumbuh subur di negara Indonesia. Salah satu kandungan utama dari jeruk nipis (Citrus aurantifolia (Christm.) Swingle) adalah flavonoid yang memberikan berbagai macam aktivitas farmakologi sebagai antifungi, antibakteri dan antikanker. Penelitian ini bertujuan untuk mengetahui efektivitas air perasan jeruk nipis, (Citrus aurantifolia (Christm.) Swingle) dalam menghambat pertumbuhan jamur Candida albicans. Metode yang digunakan dalam penelitian ini adalah dengan cara dilusi padat yaitu dengan cara menanam biakan suspensi jamur Candida albican sebanyak 1 ml yang telah di sesuaikan kekeruhannya dengan larutan standar Mc Farland 0.5 pada media SDA (Sabouraud Agar Dexrose) dengan penambahan air perasan jeruk nipis sebanyak 2 ml dengan konsentrasi 125%, 150%, 175% dan 200%. Di inkubasi selama 2-3 hari pada 370C, dan diamati pertumbuhannya. Hasil dari pengamatan selama tiga hari menunjukan bahwa air perasan jeruk nipis tidak efektif dalam menghambat pertumbuhan jamur Candida albicans, meskipun pada konsentrasi 175% dan 200% pertumbuhan jamur pada hari pertama sangat sedikit, tetapi pada hari kedua dan ketiga masih ada perluasan pertumbuhan jamur Candida albicans.
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Tasic, Suzana, Natasa Miladinovic-Tasic i Aleksandar Tasic. "Endogene reinfection as a possible cause of recurrent genital candidose in female patients". Srpski arhiv za celokupno lekarstvo 131, nr 3-4 (2003): 149–55. http://dx.doi.org/10.2298/sarh0304149t.
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The cause of primary, recurrent genital candidosis (RGC), that 5 % of the female population was afflicted with, is still unknown. It is not clear whether RGC is a result of reifection or infection recidive caused by Candida sp. The goal of the study is to examine Candida presence in women?s genital and intestinal tract; by resistotypization of the same isolated species of Candida fungi to prove their identity as well as the validity of the stated thesis that endogenous reinfection may be one of the possible causes of RGC. The study included 70 women (T-group) afflicted with primary RGC who, at the moment of the examination, were in the phase of manifest infection. In the control group there were 70 women (C-group) not afflicted with RGC. The microbiological test consisted of the microscopic and culture examination of women?s genital and intestinal material. The Candida species were differentiated according to the germination test and the biochemical activity measured by commercial Candi-Fast-test (Mycoplasma International France) and Vitec-AMS-system (bioMerieux, France). Candi-Fast test examined the sensitivity of Candida species to antymicotics and determined the resistotypes of isolated species. The study did not show statistically significant difference between examined groups in terms of the Candida presence in intestinal tract. The Candida colonization of intestinal mucosa was proved in 24 women (34.28 %) with RGC. Eighteen women (25.71 %) of the control group, had Candida sp. in intestinal tract. The most frequent RGC agent, as well as most frequent colonizer of intestinal mucosa is Candida albicans (C. albicans - RGC - 84.28 %; T-group - intestinal tract - C. albicans - 87.50 %; C-group - intestinal tract - C. albicans - 94.44 %). In 20 women with RGC there was a presence of identical resistotypes of isolated Candida sp. Identical resistotypes of C. albicans was found in 19 women of the test group, in their genital and intestinal tract. Only in one patient it was recorded the same resistance types of C. tropicalis. In four patients Candida species isolated from genital and intestinal material were not identical. In two women with RGC C. albicans on vaginal mucosa was accompanied by C. glabrata in intestinal tract, while in two more women the presence of various resistotypes C. albicans was identified in genital and intestinal tract.
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H Khaleefa, Raghad, Luma T Ahmed i Dawood S Hameed. "Oral and Dermal Candidiasis Among Infants in Al-Battol Teaching Hospital". Diyala Journal of Medicine 19, nr 2 (15.12.2020): 147–56. http://dx.doi.org/10.26505/djm.19025350503.
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Background: Candida spp. is the yeast caused infection termed candidiasis; this is naturally found on the skin and inner the body, in an area like the gut, intestines, throat, vagina, and mouth, with the absence inciting any problems. Candida albicans is yeast naturally found in the skin; intestinal tract; vaginal and mouth. This is a polymorphic yeast (that capable of growing either as avoid shaped budding yeast, when it affect the mouth, it is typically termed oral thrush, and when it affect the dermal (diaper area) called diaper rash. clinical signs and symptoms involve white patches on the or other areas of the mouth and throat, `other signs may involve soreness and problems of swallowing. Objective: To study detection, isolation, and identification of C. albicans from infants in Al-Battol Teaching Hospital in Diyala Province by routine laboratory procedure, and identification of other species of Candida. Patients and Methods: Two hundred samples were taken from infants less than 2 years who attended Al-Battol teaching Hospital in Diyala, province during the period from October 2019 to February 2020. Method of this study by making a routine and confirmative diagnosis processes involve a microscopic examination, culture on Sabouraud’s dextrose agar for diagnosis of primary invasive candidiasis, and culture on chrome agar for differentiating between C. albicans and other spp. Results: The results of this study showed the isolates of oral samples were 12 (24%) C. albicans and 18(36.0%) C. non albicans; for dermal isolates were 10(20.0%) C. albicans and 17(34.0%) C. non albicans; and for both isolates oral and dermal samples were 13(26.0%) C. albicans and 21 (42.0) C. non albicans. Conclusion: In this study found that the male are more infected by Candida than female. And also we concluded that small age children more infected than large age. Keywords: C. albican, non-albicans Candida spp. , infants
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El-Kalyoubi, Samar, Fatimah Agili, Wael A. Zordok i Ashraf S. A. El-Sayed. "Synthesis, In Silico Prediction and In Vitro Evaluation of Antimicrobial Activity, DFT Calculation and Theoretical Investigation of Novel Xanthines and Uracil Containing Imidazolone Derivatives". International Journal of Molecular Sciences 22, nr 20 (12.10.2021): 10979. http://dx.doi.org/10.3390/ijms222010979.
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Novel xanthine and imidazolone derivatives were synthesized based on oxazolone derivatives 2a-c as a key intermediate. The corresponding xanthine 3-5 and imidazolone derivatives 6-13 were obtained via reaction of oxazolone derivative 2a-c with 5,6-diaminouracils 1a-e under various conditions. Xanthine compounds 3-5 were obtained by cyclocondensation of 5,6-diaminouracils 1a-c with different oxazolones in glacial acetic acid. Moreover, 5,6-diaminouracils 1a-e were reacted with oxazolones 2a-c in presence of drops of acetic acid under fused condition yielding the imidazolone derivatives 6-13. Furthermore, Schiff base of compounds 14-16 were obtained by condensing 5,6-diaminouracils 1a,b,e with 4-dimethylaminobenzaldehyde in acetic acid. The structural identity of the resulting compounds was resolved by IR, 1H-, 13C-NMR and Mass spectral analyses. The novel synthesized compounds were screened for their antifungal and antibacterial activities. Compounds 3, 6, 13 and 16 displayed the highest activity against Escherichia coli as revealed from the IC50 values (1.8–1.9 µg/mL). The compound 16 displayed a significant antifungal activity against Candia albicans (0.82 µg/mL), Aspergillus flavus (1.2 µg/mL) comparing to authentic antibiotics. From the TEM microgram, the compounds 3, 12, 13 and 16 exhibited a strong deformation to the cellular entities, by interfering with the cell membrane components, causing cytosol leakage, cellular shrinkage and irregularity to the cell shape. In addition, docking study for the most promising antimicrobial tested compounds depicted high binding affinity against acyl carrier protein domain from a fungal type I polyketide synthase (ACP), and Baumannii penicillin- binding protein (PBP). Moreover, compound 12 showed high drug- likeness, and excellent pharmacokinetics, which needs to be in focus for further antimicrobial drug development. The most promising antimicrobial compounds underwent theoretical investigation using DFT calculation.
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Raningsih, Ni Made, i Putu Wahyu Sri Juniantari Sandy. "Identification of Endophytic Fungi from Rhizome Galanga (Alpinia galanga L.) against Candida albicans". Metamorfosa: Journal of Biological Sciences 5, nr 2 (18.10.2018): 205. http://dx.doi.org/10.24843/metamorfosa.2018.v05.i02.p10.
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The main objectives of this research were to isolat and identify endophytic fungi antagonists of Candida albicnas from galanga rhizomes. Samples of galanga rhizome were collected from Gitgit plantation in Gitgit village, Buleleng regency. Isolation and identification were conducted in Food Microbiology Laboratory, Faculty of Agriculture, Udayana University. There were three isolates identified with inhibitory persentage againts Candida albicans i.e. Trichoderma viridae (26.07±3.76%), Trichoderma harzianum (45.11±5.84%) and Fusarium oxyforum (20.11±5.61%).
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K.salih, Ahmed. "SYNERGISTIC EFFECTS OF PLANT EXTRACTS AND ANTIFUNGAL DRUGS ON C. ALBICANS." EPH - International Journal of Biological & Pharmaceutical Science 2, nr 1 (27.04.2016): 18–22. http://dx.doi.org/10.53555/eijbps.v2i1.9.
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fungi have surroundedus and have affected our life, when changed or getting out from control it should be treated and when change to multi drug resistant it is difficult to treat by antibioticsso wecan use plant extracts to produce valuable protectionagainst infection.Objective: In this study, we used agarwell diffusion method to investigate the effect of antifungal drug ofplant extractson Candida albicans,Method: Candida albicanswas isolated from oral cavity of Sulaimani Emergency hospital patients.The isolates consisted c.albicans(n=15). The microorganisms were divided into four groups in a factorial design: control, FGE with blackseed, FGE without black seed, black seed without FGE and antibiotic (Fluconazole). The minimum inhibitory concentration of FGE was calculated by using a gradient of concentrations and observeingtheir inhibitory effects on C. albicans.Results: fresh garlic extract(FGE extract)displayed evident inhibition against Candida albicansby producingmoreinhibitionzone (p < 0.05), Black seed extract (BL extract) showed no inhibitory effect on C. albicansat %10 concentration.However,synergism of BI with FGE have shown significant effects on it (P < 0.05) and fluconazole had littleeffect on Candidaalbicans. Conclusion: the result suggestthatFGE can improve the antibiotic sensitivity and BI don’t effect on C.albicans
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David, O. M., P. O. Adeola, T. O. Faloye, B. J. Owabumoye, O. Famurewa, C. O. Esan i I. P. Ade-Ojo. "Detection of virulence factors and antifungal resistant patterns of Candida species isolated from women with urinary tract infections". Bayero Journal of Pure and Applied Sciences 15, nr 1 (9.12.2022): 50–56. http://dx.doi.org/10.4314/bajopas.v15i1.6.
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The incidence of Candida species has increased among females of child bearing age over the years. There has also been an increase in the resistance of these Candida species to the antifungal drugs used to treat them. This study is aimed at detecting the prevalence of Candida species among patients with urinary tract infections (UTI) attending gynecological unit of Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria. The distribution of pathogenic factors and the antifungal resistance pattern of the isolates were also determined. A total of 61 subjects of different ages and socioeconomic status attending the health facility were enrolled in this study. Samples of high vaginal swab (HVS) were collected from each of the participant and screened. A total of 36 candidal isolates were recovered from the samples out of which 11 (30.5%) were predominantly Candida albican, 5 (13.9%) Candida krusei, 4 (11.1%) Candida glabrata, 2 (5.6%) Candida tropicalis and 14 (38.9%) were not identified beyond the genus level. Ten (27.8%) of the isolates were not able to produce biofilm. Out of those that produce biofilm 17 (47.2%) produced weak biofilm, 5 (8.2%) produced moderate biofilm, while 4 (11.1%) produced strong biofilm. Spectrophotometer was used to quantify those that produce biofilm 9 (25%) produced moderate biofilm while 16 (44.4%) produced strong biofilm. The isolates were subjected to various pathogenicity tests which include haemolysis, catalase, phospholipase and hydrolysis. This test shows that Candida species has the highest percentage to the entire test while none of C. glabrata produced haemolysin and phospholipase. Antifungal assay was then carried out on the entire organisms showed Candida albicans to have low resistance to the azoles drugs while the non-albican Candida shows higher resistance to it. Extremely high prevalence of Candida albicans and Candida species were documented in this study. These findings should be taken into account in further research concerning presence of Candida among patient with sexually transmitted disease in Nigeria.
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Otor, Dorathy, Matthew Otor, Nonye Okafor, Kate Darlington i OS Adima. "Mineral Composition, Phytochemicals and Anti-microbial Activity of Coconut Water (Cocos nucieferal) on Candida albicans and Lactobacillus acidophilus". Journal of Medical and Biological Science Research 7, nr 3 (25.06.2021): 10–14. http://dx.doi.org/10.36630/jmbsr_21004.
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The phytochemicals and anti-microbial activity of coconut water on Candida albicans and Lactobacillus acidophilus and also its mineral composition were investigated for its medicinal potential. The study revealed the presence of Pb, Cu, Zn, Cd, Fe, Ca, Na, K, Mg and Mn. The concentration of the elements in ppm were as follows Pb (0.058), Cu (0.012), Zn (0.202), Cd (0.028), Fe (0.109), Ca (0.368), Na (1.300), K (1.740), Mg (0.947), Mn (0.229). Saponins, alkaloids, steroids, cardiac glycosides and carbohydrates were the phytochemicals detected. The coconut water was tested against Candida albicans and Lactobacillus acidophilus using Agar well diffusion method. Inhibitory zone diameter ranges from 13-25 mm. The results showed a concentration-dependent antimicrobial activity against the tested organisms. Inhibitory activity exhibited by coconut water against these micro-organisms is an indication of the presence of bioactive compounds which can be identified, isolated and incorporated into modern oral care systems for controlling dental caries. Keywords: Coconut water, phytochemicals, Candida albican, Lactobacillus acidophilus
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Kamoda, Harunai, Shelly Lelyana i Vinna Kurniawati Sugiaman. "Kadar hambat minimum dan kadar bunuh minimum ekstrak etanol lengkuas merah (Alpinia galanga L.) terhadap pertumbuhan Candida albicansThe minimum inhibitory concentration and a minimum lethal dose of red galangal (Alpinia galanga L.) ethanolic extract on the growth of Candida albicans". Jurnal Kedokteran Gigi Universitas Padjadjaran 32, nr 1 (30.04.2020): 1. http://dx.doi.org/10.24198/jkg.v32i1.25422.
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Pendahuluan: Kandidiasis rongga mulut merupakan infeksi yang disebabkan oleh jamur patogen Candida albicans, dengan prevalensi cukup tinggi yaitu 20% - 75%. Obat antijamur yang umum digunakan untuk pengobatan kandidiasis rongga mulut adalah nistatin, akan tetapi nistatin memiliki efek samping dan harganya relatif mahal. Sebagai alternatif lain digunakan tanaman obat seperti lengkuas merah (Alpinia galanga L) yang diduga memiliki aktivitas antijamur. Tujuan penelitian ini adalah untuk mengetahui kadar hambat minimum (KHM) dan kadar bunuh minimum (KBM) ekstrak etanol lengkuas merah terhadap pertumbuhan Candida albicans. Metode: Jenis penelitian eksperimental murni dengan membandingkan kelompok uji yang mengandung ekstrak etanol lengkuas merah (alpinia galanga L) dengan konsentrasi 200mg/ml; 100mg/ml; 50mg/ml; 25mg/ml; 12,5mg/ml; 6,25mg/ml; kontrol positif berupa nistatin, dan kontrol negatif berupa DMSO 10% terhadap pertumbuhan Candida albicans dengan mengamati kekeruhan larutan pada 96 well plate menggunakan spectrophotometer dan KBM ditentukan menggunakan colony counter dengan pengulangan sebanyak 4 kali. Analisis data menggunakan uji parametrik ANOVA dan uji Post Hoc Tuckey. Hasil: Hasil uji ANOVA nilai p 0,00 yang artinya bahwa kedua data memiliki nilai yang signifikan antar perlakuan, dan uji Post Hoc Tuckey memperlihatkan terdapat perbedaan yang signifikan pada setiap kelompok uji terhadap jumlah Candida. Simpulan: Kadar Hambat Minimum (KHM) ekstrak etanol lengkuas merah (Alpinia galanga L) terhadap pertumbuhan Candida albicancs adalah 200mg/ml namun hanya menghambat 60%, sedangkan ekstrak etanol lengkuas merah (Alpinia galanga L) tidak dapat membunuh Candida albicans.Kata kunci: Candida albicans, lengkuas merah, Alpinia galanga L. ABSTRACTIntroduction: Candida albicans is a pathogenic fungus that can cause oral candidiasis, reaches 20% - 70% prevalence in human. Antifungal drugs often used for oral candidiasis treatment is nystatin, but nystatin has many harmful side effects, and its price is relatively high. Therefore, herbal remedies such as red galangal (Alpinia galanga L.), which presumed to have antifungal activity, can be used as an alternative treatment. The purpose of this research was to determine the minimum inhibitory concentration and a minimum lethal dose of red galangal ethanolic extract on the growth of Candida albicans. Methods: This research was an experimental laboratory, conducted by comparing the test group containing ethanolic extracts of red galangal (Alpinia galanga L.) with the concentrations of 200mg/ml; 100mg/ml; 50mg/ml; 25mg/ml; 12.5mg/ml; and 6.25mg/ml; positive control group was treated with nystatin; and negative control with 10% DMSO. The solutions on 96 well plates were observed with a spectrophotometer, and the minimum killing concentration (MKC) was determined using a colony counter, and the experiment was replicated four times. The result was then analysed with ANOVA parametric test and the Post-Hoc Tuckey test afterwards. Results: The result of the ANOVA test showed that the p-value was < 0.05, which means that all treatments have a significant value, while the Post-Hoc Tuckey test indicated that there were significant differences in each group regarding the number of Candida albicans. Conclusion: Minimum Inhibitory Level (MIC) of red galangal (Alpinia galanga L) ethanolic extract against Candida albicans growth is 200mg/ml but only inhibits 60% of the growth. In contrast, the extract is unable to mortally affects the Candida albicans.Keywords: Candida albicans, red galangal, Alpinia galanga L.
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Mock, Ruth C., Jordan H. Pollack i Tadayo Hashimoto. "Carbon dioxide induces endotrophic germ tube formation in Candida albicans". Canadian Journal of Microbiology 36, nr 4 (1.04.1990): 249–53. http://dx.doi.org/10.1139/m90-043.
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Candida albicans formed germ tubes when exposed to air containing 5 to 15% carbon dioxide (CO2). The CO2-mediated germ tube formation occurred optimally at 37 °C in a pH range of 5.5 to 6.5. No germ tubes were produced at 25 °C, even when the optimal concentration of CO2 (10%) was present in the environment. The requirement of CO2 for germ tube formation could be partially substituted by sodium bicarbonate but not by N2. Carbon dioxide was required to be present throughout the entire course of germ tube emergence suggesting that its role is not limited to an initial triggering of morphogenic change. We suggest that carbon dioxide may be a common effector responsible for the germ tube promoting activity of certain chemical inducers for C. albicans. Key words: Candida albican germ tubes, CO2-induced germ tube formation, endotrophic germ tube formation.
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Fajoyomi Bridget U, Azubike Faustina C i Daodu Bamidele T. "Prevalence of Candida albicans species among females with symptoms". GSC Biological and Pharmaceutical Sciences 18, nr 1 (30.01.2022): 073–77. http://dx.doi.org/10.30574/gscbps.2022.18.1.0026.
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Candida albicansisan opportunistic fungal pathogen found as part of the normal microflora in humans, it is one of approximately 200 species in the genus Candida.Candidaalbicans is the most common type of fungus to cause yeast infectionsand accounts for up to 75% of all candidalinfections.A study on the prevalence of vaginal infections was carried out on women at the effective Medical Laboratory, Port-Harcourt. The Clinical symptoms noted amongst women were itching, vaginal discharge, irritation of the vulvovaginal.A total of 100 samples were collected and analysed, a percentage occurrence of 64% growth and 36%no growth was gotten. Germ tubes test carried out shows that out of 64 samples that had growth, 42 of the samples isolated were positive and 22 were negative.Gram staining reactions of Candida albicans isolated shows that all were gram positive.This shows that Candida albicanswas prevalent. Antifungal susceptibility test showed susceptibility of 42%, this was observed in Nystatin, which indicates that it’s a better antifungal drug in the treatment of Candida albican infection above other antifungal drugs used for the analysis which include Griseoflucin, Fluconazole, Sivoketonazole.The fact that a patient presents symptoms of candidiasis does not mean that the infection is caused by Candida albicans. Proper diagnosis is required to ascertain the main cause of the infection.
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Robert, R., S. Nail, A. Marot-Leblond, J. Cottin, M. Miegeville, S. Quenouillere, C. Mahaza i J. M. Senet. "Adherence of Platelets to CandidaSpecies In Vivo". Infection and Immunity 68, nr 2 (1.02.2000): 570–76. http://dx.doi.org/10.1128/iai.68.2.570-576.2000.
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ABSTRACT The in vivo interactions of platelets with Candidaspecies yeast cells were investigated in a murine model. Mice were injected intravenously via the lateral caudal vein, and blood drawn by periorbital puncture was collected in phosphate-buffered saline–formaldehyde to avoid in vitro platelet activation. The study of the clearance of blastoconidia of Candida albicans andCandida glabrata showed that these cells disappeared quickly from the bloodstream. Microscopic observation of blood samples, stained by Calcofluor white or May Grunwald Giemsa, demonstrated the rapid attachment of platelets to fungal elements of all theCandida spp. tested. The attachment of murine platelets toC. albicans cells, observed by scanning electron microscopy, revealed morphological changes. The platelets lost their discoid shape, generated pseudopodia, and flattened against the yeast cells. The reversibility of platelet binding to C. albicansby chelating agents suggests a cation-dependent link. In contrast, the fixation of C. glabrata and Candida tropicaliswas not modified by chelating agents. The mechanisms involved in the in vivo adherence of platelets to Candida cells may therefore differ according to the species of Candida.
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Elanda, Felicia Khofifah. "Candida albicans PADA AIR KOLAM RENANG DI KECAMATAN JOMBANG KABUPATEN JOMBANG". Jurnal Insan Cendekia 6, nr 2 (9.09.2019): 90–95. http://dx.doi.org/10.35874/jic.v6i2.543.
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Pendahuluan : Kolam renang sebagai sarana umum dapat berpotensi menjadi sarana penyebaran bibit penyakit maupun gangguan kesehatan akibat kondisi sanitasi lingkungan kolam renang yang buruk. Candida albicans pada air kolam renang dapat diperoleh dari kuku penderita kandidiasis vaginitis yang secara tidak sengaja mencemari air kolam renang. Tujuan : Mengetahui gambaran Candida albicans pada air kolam renang di Kecamatan Jombang Kabupaten Jombang. Metode : penelitian berupa deskriptif. Populasi berupa seluruh kolam renang di kolam renang pariwisata Kecamatan Jombang Kabupaten Jombang sejumlah 5 kolam renang. Variabel adalah Candida albicans pada Air Kolam Renang di Kecamatan Jombang Kabupaten Jombang. Alat ukur berupa observasi laboratorium. Pengolahan data dengan cooding dan tabulating. Analisa data berupa persentase. Hasil : penelitian ini adalah KR 1 tidak ada Candida albicans, KR 2 tidak ada Candida albicans, KR 3 tidak ada Candida albicans, KR 4 tidak ada Candida albicans, KR 5 tidak ada Candida albicans .Sehingga ada Candida albicans sejumlah 0 (0%) dan tidak ada Candida albicans sejumlah 5 (100%). Kesimpulan : didapatkan hasil pada air kolam renang Tidak Ada Candida albicans sebanyak 0. Saran : penelitian ini diharapkan masyarakat dapat lebih selektif dan berhati-hati saat berada di kolam renang,
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Sari Sovianti, Cyntya, i Mutia Devi. "Recurrent Vulvovaginal Candidiasis". Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, nr 5 (17.02.2021): 474–83. http://dx.doi.org/10.32539/bsm.v5i5.280.
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Vulvovaginal candidiasis is a common fungal infection caused by Candida Sp, especially Candida albicans. Recurrent vulvovaginal candidiasis was defined as the occurrence of four or more episodes of vulvovaginal candidiasis in 12 months period. As many as 9% of women from various populations have recurrent vulvovaginal candidiasis. Vulvovaginal candidiasis affects the quality of life, mental health, and sexual activity. There are many predisposing factors that caused recurrent vulvovaginal candidiasis, such as genetics, host, habit, idiopathic and non-albican candida microbes. Management of recurrent vulvovaginal candidiasis includes elimination of predisposing factors; mycological culture diagnosis and identification of specific Candida species; followed by microbiological examination to confirm the sensitivity of the azole group to Candida sp. Further, oral, or topical therapy should be continued until the patient is asymptomatic and culture-negative. Patients should receive induction therapy followed by maintenance suppressive therapy for six months.
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Sari Sovianti, Cyntya, i Mutia Devi. "Recurrent Vulvovaginal Candidiasis". Bioscientia Medicina : Journal of Biomedicine and Translational Research 5, nr 3 (17.02.2021): 498–507. http://dx.doi.org/10.32539/bsm.v5i3.280.
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Vulvovaginal candidiasis is a common fungal infection caused by Candida Sp,especially Candida albicans. Recurrent vulvovaginal candidiasis was defined asthe occurrence of four or more episodes of vulvovaginal candidiasis in 12 monthsperiod. As many as 9% of women from various populations have recurrentvulvovaginal candidiasis. Vulvovaginal candidiasis affects the quality of life,mental health, and sexual activity. There are many predisposing factors thatcaused recurrent vulvovaginal candidiasis, such as genetics, host, habit,idiopathic and non-albican candida microbes. Management of recurrentvulvovaginal candidiasis includes elimination of predisposing factors; mycologicalculture diagnosis and identification of specific Candida species; followed bymicrobiological examination to confirm the sensitivity of the azole group toCandida sp. Further, oral, or topical therapy should be continued until the patientis asymptomatic and culture-negative. Patients should receive induction therapyfollowed by maintenance suppressive therapy for six months.
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Bajunaid, Salwa Omar. "How Effective Are Antimicrobial Agents on Preventing the Adhesion of Candida albicans to Denture Base Acrylic Resin Materials? A Systematic Review". Polymers 14, nr 5 (24.02.2022): 908. http://dx.doi.org/10.3390/polym14050908.
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Denture stomatitis is a common oral infection caused by Candid albicans. It occurs under removable dentures due to several causative and contributing factors. If not treated, it can lead to fatal systemic candida infections. Different materials and techniques have been used to treat denture stomatitis; however, no single treatment has succeeded. The purpose of this study was to review novel techniques for incorporating antimicrobial and protein repellent agents into denture acrylic resin materials and their effect on the adhesion of Candida albicans to denture base acrylic resin materials to prevent and/or treat denture stomatitis. A systematic review was conducted in which an electronic search was undertaken using different databases and relevant keywords. The literature search revealed numerous studies describing different antifungal materials incorporated into different denture acrylic resin materials. The investigated materials showed significant antimicrobial activity with slight or no effect on the physical and mechanical properties; however, the optical properties were particularly affected with higher concentrations. The incorporation of antimicrobial agents to reduce or prevent Candida albicans biofilm formation on acrylic resin proved to be very effective, and this effect was found to be proportional to the percentage of the material used. The latter should be considered carefully not to alter the physical, mechanical or optical characteristics of the denture base material.
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Tran, Vuvi G., Na N. Z. Nguyen i Byungsuk Kwon. "CD137 Signaling Is Critical in Fungal Clearance during Systemic Candida albicans Infection". Journal of Fungi 7, nr 5 (14.05.2021): 382. http://dx.doi.org/10.3390/jof7050382.
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Invasive fungal infections by Candida albicans frequently cause mortality in immunocompromised patients. Neutrophils are particularly important for fungal clearance during systemic C. albican infection, yet little has been known regarding which surface receptor controls neutrophils’ antifungal activities. CD137, which is encoded by Tnfrsf9, belongs to the tumor necrosis receptor superfamily and has been shown to regulate neutrophils in Gram-positive bacterial infection. Here, we used genetic and immunological tools to probe the involvement of neutrophil CD137 signaling in innate defense mechanisms against systemic C. albicans infection. We first found that Tnfrsf9−/− mice were susceptible to C. albicans infection, whereas injection of anti-CD137 agonistic antibody protected the host from infection, suggesting that CD137 signaling is indispensable for innate immunity against C. albicans infection. Priming of isolated neutrophils with anti-CD137 antibody promoted their phagocytic and fungicidal activities through phospholipase C. In addition, injection of anti-CD137 antibody significantly augmented restriction of fungal growth in Tnfrsf9−/− mice that received wild-type (WT) neutrophils. In conclusion, our results demonstrate that CD137 signaling contributes to defense mechanisms against systemic C. albicans infection by promoting rapid fungal clearance.
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Yulianti, Evy, Anna Rakhmawati i Kartika Ratna Pertiwi. "OPTIMATION OF ANTIMICROBIAL SUBSTANCE PRODUCTION IN CELL FREE EXTRACT FROM THERMOPHYLIC BACTERIA FERMENTATION AFTER MERAPI ERRUPTION". Jurnal Sains Dasar 4, nr 2 (20.05.2016): 140. http://dx.doi.org/10.21831/jsd.v4i2.9089.
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The aims of this study was to investigate the effect of medium with different pH (6,7,9), salt concentration (0,5; 1; 2 %) and fermentation periode (24 and 48 hr) to the antimicrobial activity of cell free extract to three pathogens, Eschericia coli, Staphylococcus aureus, and Candida albican. This study consists of antimicrobial compounds production with different medium and continued by antimicrobial tested to fungi and bacterial pathogens Eschericia coli, Staphylococcus aureus, and Candida albican by Kirby Bauer method with paper disk. Different salt concentration, pH and fermentation periode affected the antimicrobial activity potency of cell free extract yielded by thermophylic bacteria. Treatment which yielded CFE with the best antimicrobial activity was treatment with 24 hr fermentation, pH 7 and salt concentration 2% to S aureus and pH 6 salt concentration 1% to E coli. Cell free extract had no potency as antifungi to Candida albicans except CFE yielded by thermophylic bacteria fermented in medium with pH 7 and salt concentration 1% in 24 hr with inhibition zone index 1,17. Keywords: cell free extract, antimicrobial, pH, salt concentration, fermentation period
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Situmorang, Novidawati Boru. "ANTIFUNGAL EFFECTIVENESS OF LEAF ETHANOL EXTRACT WAKE UP (COLEUS AMBOINICUS)AGAINST THE FUNGI CANDIDA ALBICANS". JURNAL FARMASIMED (JFM) 4, nr 2 (28.04.2022): 98–102. http://dx.doi.org/10.35451/jfm.v4i2.1061.
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Daun bangun-bangun (Coleus amboinicus), merupakan Salah satu tumbuhan yang berpotensi sebagai obat dan telah sering digunakan oleh masyarakat. Kandungan senyawa Flavonoid dalam daun Bangun-bangun diyakini memiliki manfaat dan berpotensi sebagai antijamur terhadap Candida albicans. Selain itu adanya resistensi akan obat kimiawi sehingga pengobatan yang bersumber dari alam mulai dikembangkan. Tujuan dari penelitian ini yaitu untuk mengetahui aktivitas antijamur ekstrak etanol daun Bangun-bangun (Coleus amboinicus) terhadap bakteri Candida albicanss. Penelitian diawali dengan melakukan pemeriksaan metabolit alkaloid, saponin, flavanoid, tanin dan kemudian pengujian aktivitas antijamur terhadap Candida albicans dengan beberapa konsentrasi yaitu 5, 10, dan 15%, metode difusi agar kertas cakram. Hasil skrining fitokimia daun Bangun-bangun menunjukkan adanya alkaloid, tanin, flavonoid, dan saponin. Hasil pemeriksaan karakteristik serbuk simplisia daun bangun-bangun didapat kadar air 9,27%, kadar sari larut air 14,5%, kadar sari larut etanol 9,76%, sesuai dengan materia medika indonesia. Hasil skrining fitokimia yang didapat yaitu fenolik, flavonoid, saponin, steroid/triterpenoid. Pengujian aktivitas antijamur ekstrak etanol daun bangun-bangun menunjukkan diameter zona hambat pada konsentrasi 5%, 10%, 15%, adalah 14,47 mm, 15,46 mm, 16,34 mm. Maka dapat disimpulkan bahwa semakin tmeningkat konstrasi ekstrak,makasemakin besar diameter zonahambatnya.
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Mokodongan, Triswa A., Herny E. I. Simbala i Henki Rotinsulu. "AKTIVITAS ANTIMIKROBA DARI EKSTRAK DAN FRAKSI KARANG LUNAK Sarcophyton sp., DARI PERAIRAN PONTENG DESA TUMBAK MINAHASA TENGGARA TERHADAP MIKROBA PATOGEN Staphylococcus aureus, Escherichia coli, dan Candida albicans". PHARMACON 8, nr 4 (28.11.2019): 991. http://dx.doi.org/10.35799/pha.8.2019.29380.
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ABSTRACTSoft coral sarcophyton sp., poruduces natural chemical compounds and is known as a natural product. These natural chemical compounds have the potential as a source of natural medicine. Soft coral sarcophyton sp., has antimicrobial, antibacterial, anti-fungal, anti-tumor,neurotoxic, and anti-inflammatory activities that are beneficialt to the pharmaceutical industry. This study aims to determine the biological activity of soft corals Sarcophyton sp., collected from the waters of Ponteng Tumbak Village, Southeast Minahasa Regency on microbial growth of staphylococcus aureus, Escherichia coli, and Candida albicans. Soft coral samples were macerated with 96% of ethanol solvent and partitioned liquid-liquid using methanol, chloroform, and n-hexane solvents. Staphylococcus aureus and Escherichia coli bacteria with a medium category, and were unable to inhibit the growth of the fungus Candida albicans.Keywords: Sarcophyton sp., Antimicrobial, Staphylococcus aureus, Escherichia coli, Candida albicans.ABSTRAKKarang lunak Sarcophyton sp., merupakan salah satu jenis karang lunak yang memproduksi senyawa kimia alami dan dikenal dengan istilah natural product. Senyawa kimia alami tersebut berpotensi sebagai sumber obat alami. Karang lunak Sarcophyton sp., mempunyai aktivitas antimikroba, antibakteri, anti fungi, anti tumor, neurotoksik, dan anti inflamasi yang bermanfaat bagi industry farmasi. Karang lunak Sarcophyton sp., ditemukan di daerah perairan Poteng Desa Tumbak Minahasa Tenggara. Penelitian ini bertujuan untuk mengetahui adanya aktivitas daya hambat pertumbuhan mikroorganisme dari Karang lunak Sarcophyton sp., terhadap mikroba Staphylococcus aureus, Escherichia coli, dan Candida albicans. Sampel diekstraksi metode maserasi dengan pelarut etanol dan fraksinasi menggunakan pelarut methanol, kloroform, dan n-heksan. Berdasarkan hasil penelitian menunjukkan bahwa masing-masing ekstrak dan fraksi mampu menghambat pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli dengan kategori daya hambat sedang. Sedangkan masing-masing ekstrak dan fraksi pada Jamur Candida albicans tidak mampu menghasilkan aktivitas antibakteri. Kata Kunci : Sarcophyton sp., Antimikroba, Staphylococcus aureus, Escherichia coli, dan Candida albican.
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Karwiti, Witi, Asrori Asrori, Ardiya Garini i Bayu Meilanda Akbar. "THE PRESENCE OF Candida albicans IN URINE OF DIABETES MELLITUS AT BHAYANGKARA HOSPITAL PALEMBANG". Jambura Journal of Health Sciences and Research 4 (28.02.2022): 99–105. http://dx.doi.org/10.35971/jjhsr.v4i0.13070.
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Abstrak Penyakit diabetes mellitus merupakan penyakit degeneratif yang disebabkan oleh kadar glukosa darah puasa yang melebihi 110 mg/dl. Jika konsentrasi glukosa darah melebihi 160 sampai 180 mg/dl, maka glukosa akan keluar bersama urin. Keadaan ini disebut dengan glukosuria. Glukosuria memicu infeksi Candida albicans dan dapat menimbulkan abses ginjal, abses perirenal, infeksi hepar, meningitis, dan lain-lain. Penelitian bertujuan untuk mengetahui keberadaan Candida albicans pada urin penderita diabetes mellitus di Rumah Sakit Bhayangkara Palembang. Jenis penelitian adalah deskriptif dengan pendekatan cross-sectional. Metode pemeriksaan glukosuria dengan carik celup, sedangkan pemeriksaan jamur Candida albicans menggunakan metode Germ-tube test. Besar sampel adalah 45 penderita diabetes mellitus yang diambil dengan teknik purposive samplimg.Hasil penelitian didapatkan dari 45 penderita diabetes mellitus, sebanyak 9 (20%) positif Candida albicans dan 36 (80%) negatif Candida albicans. Berdasarkan umur, dari 29 penderita diabetes mellitus berumur 60 tahun, didapatkan 3 (10,3%) positif Candida albicans. Berdasarkan jenis kelamin, dari 24 penderita diabetes mellitus berjenis kelamin perempuan, didapatkan 7 (29,2%) penderita positif Candida albicans. Hasil pemeriksaan glukosuria positif, dari 13 penderita, sebanyak 4 (30,8%) penderita positif Candida albicans. Penderita dengan penyakit tidak terkontrol, dari 22 penderita sebanyak 3 (13,6%) penderita positif Candida albicans. Hasil uji statistik menggunakan Chi-square didapatkan, ada hubungan yang signifikan antara umur dengan keberadaan jamur Candida albicans pada urin penderita diabetes mellitus (pValue=0,050). Sedangkan untuk variabel jenis kelamin (pValue=0,143), pemeriksaan glucosuria (pValue=0,411) dan pengontrolan penyakit (pValue=0,459) tidak ada hubungan yang signifikan (pValue0,05). Dengan demikian, disarankan penderita diabetes mellitus untuk selalu mengontrolkan penyakitnya agar mencegah infeksi Candida albicans. Kata kunci: Candida albicans, Penyakit Diabetes Mellitus, Germ-tube test, Urin Abstract Diabetes mellitus is a degenerative disease caused by blood sugar level is more than 110 mg/dl. If blood sugar level is more than 160 until 180 mg/dl, glucose will be excreted in urine. This situation called glucosuria. Glucosuria triggers Candida albicans infection and causes kidney abscess, perirenal abscess, hepar infection, meningitis, etc. The purpose of this study was to know the presence of Candida albicans in urine of diabetes mellitus patients at Bhayangkara Hospital Palembang. The type of this study was descriptive with cross-sectional approach. The technique of glucosuria test was dip stick, while the method of Candida albicans is Germ-tube test. The sampel size was 45 diabetes mellitus patients collected by purposive sampling technique. The research result showed from 45 diabetes mellitus patients, there were 9 (20%) diabetes mellitus patients positive Candida albicans and 36 (80%) negative Candida albicans. Based on age, from 29 diabetes mellitus in patients aged 60 years, there were 3 (10,3%) positive Candida albicans. Based on sex, from 24 women diabetes mellitus patients, there were 7 (29,2%) positive Candida albicans. Based on glucosuria test, from 13 diabetes mellitus patients positive glucosuria, there were 4 (30,8%) positive Candida albicans. Based on disease control, from 22 diabetes mellitus patients with uncontrolled disease, there were 3 (13,6%) positive Candida albicans. The results of statistical tests using Chi-square were obtained, there was a significant relationship between age and the presence of the fungus Candida albicans in the urine of patients with diabetes mellitus (pValue = 0.050). Meanwhile, for the variables of sex (pValue=0,143), glucosuria examination (pValue=0,411) and disease control (pValue=0,459) there was no significant relationship (pValue 0.05). Therefore, it is hoped that diabetes mellitus patients to always control the disease to prevent Candida albicans infection.
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Mongi, Alfa, Deiske A. Sumilat, Fitje Losung, Remmy E. P. Mangindaan, Rosita A. Lintang i Suzanne L. Undap. "BIOAKTIVITAS JAMUR Aspergillus flavus YANG BERSIMBION DENGAN ASCIDIAN Eudistoma sp." JURNAL PESISIR DAN LAUT TROPIS 8, nr 2 (30.05.2020): 11. http://dx.doi.org/10.35800/jplt.8.2.2020.28765.
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Ascidian is a marine invertebrate that produce bioactive compounds such as antibacterial and antifungal. The purpose of this study was to obtain symbiotic fungi isolates, ethyl acetate extracts from ascidian symbiotic isolates, and to determine the antibacterial and antifungal activities of ethyl acetate extracts of symbiotic isolates using the diffusion method (disc diffusion Kirby and Bauer) against Escherichia coli, Staphylococcus aureus bacteria and against the Candida albicans fungus. The results obtained 1 ascidian species which was cultured to obtain pure isolates, the pure isolates were tested molecularly and the results showed that the isolate was Aspergillus flavus, then the isolates were grown on rice medium and extracted. The results of the fungal extract showed the presence of antibacterial and antifungal activity against Escherichia coli by 10 mm, Staphylococcus aureus by 19 mm and against the Candida albicans by 13.5 mm. Keywords : Ascidian, Eudistoma sp., Aspergillus flavus, Antibacterial, Antifungal, Symbiotic. AbstrakAscidian merupakan avertebrata laut yang dapat menghasilkan senyawa bioaktif yang seperti antibakteri dan antijamur. Tujuan dari penelitian ini yaitu mendapatkan isolat jamur simbion dari ascidian, mendapatkan ekstrak etil asetat dari isolat jamur simbion ascidian, dan menguji aktivitas antibakteri dan antijamur ekstrak etil asetat isolat jamur simbion dengan metode difusi agar (disc diffusion Kirby and Bauer) terhadap bakteri Escherichia coli, Staphylococcus aureus dan terhadap jamur Candida albicsans. Hasil penelitian didapatkan 1 jenis ascidian yang kemudian dikultur untuk mendapatkan isolat murni, isolat murni diuji secara molekuler dan didapati hasil bahwa isolat tersebut merupakan jamur Aspergillus flavus. Isolat tersebut kemudian ditumbuhkan pada media nasi dan diekstrak. Hasil ekstrak jamur tersebut menunjukkan adanya aktivitas antibakteri dan antijamur terhadap bakteri Escherichia coli sebesar 10 mm, Staphylococcus aureus sebesar 19 mm dan terhadap jamur Candida albicsans 13,5 mm. Kata kunci : Ascidian, Eudistoma sp., Aspergillus flavus, Antibakteri, Antijamur, Simbion.
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Shifaa T. J. AL-Assaf, Maha A. Al-Rejaboo i Ayad-C.AL-.Daody. "Assessing the impact of quercetin isolated from Ammi majus seeds upon Candida spp. isolants isolated from different sources". International Journal of Research in Pharmaceutical Sciences 11, nr 4 (23.09.2020): 5141–49. http://dx.doi.org/10.26452/ijrps.v11i4.3118.
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Quercetin has been extracted from Ammi majus plant using ethanol via soxhlet system. Further, the substance was diagnosed by three binary and mono-layered chromatographical devices beside chronographical quantitative separation. Total of 45 patients was inflicted with mouth infections and urinary tract in both genders. The momentary vaginal infections among different ages of people settled in different regions of Nineveh district / Iraq were considered for the study. The study patients were identified using microscopic testing, selective differential medium (CHROM candida agar) and Vitek system. The isolation results inferred that the mouth infection is caused by most yeasts such as Candida parapsilosis (the most frequent),. The urinary tract infection is concerned, and most of the infections were reportedly caused by C. parapsilosis, C. tropicalis and C. albicans. with regards to the vaginal infections cases, C. albicans fungus has been the most frequent. Bio chemical tests were conducted using Vitek for the isolants studied, in which there were differences in the study results. Quercetin was extracted from Candid spp. The increase in the inhibition of quercetin is noted, whenever its concentration is increased. With regards to the anti-fungals Nystantin, for the concentration of 100IU/ml.and Clotrimazole 30mg/ml had inhibited the yeast Candid spp.
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Dash, Chinmaya, Abhinanda Pal i Sulekha Sinha. "Evaluation of Candida Score: a bedside scoring system for early antifungal therapy in non-neutropenic critically ill patients". International Journal of Advances in Medicine 6, nr 2 (25.03.2019): 521. http://dx.doi.org/10.18203/2349-3933.ijam20191169.
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Background: Invasive Candida infections are the most common invasive fungal infections. Multiple site colonization plays a major role. Further decrease in host immunity (e.g. neutropenia, diabetes mellitus etc.) aggravates local invasion and dissemination which finally leads to candidemia. Hence the study was done to evaluate “Candida Score” in non-neutropenic critically ill patients for early antifungal therapy.Methods: In this prospective observational cohort study, all critically ill patients having sepsis or septic shock on admission or during their stay in ICU stay were included in the study. The components of “Candida Score” like severe sepsis, total parenteral nutrition, surgery, and multifocal Candida colonization were as per Leone et al. Clinical sepsis was given score of 2 if present and 0 if absent. The other variables were given score 01 if present and 0 if absent. The score more than 2.5 is considered significant.Results: Out of 78 patients admitted in the ICU a total of 26 blood culture positives were reported. The prevalence of Candidemia (based on culture) was 23.1% (n=06). The strains isolated were Candida non albicans (n=4, 66.7%) and Canida albicans (n=2, 33.3%). Candida was isolated in different samples other than blood culture of 26(33.33%). The most common specimen with Candida isolation was from urine (n=14, 60.87%), followed by endotracheal aspiration and sputum (n=3, 13% each) and BAL fluid (n=1, 04.3%). Among the isolates Candida non albicans (n=12, 52.2%) was more prevalent than Candida albicans (n=11, 47.8%). The prevalence was maximum for the age group of 60 to 69 years (42.31%) followed by 70 to 79 yrs and 50-59 yrs. Among all patients, 14 patients were referred in our hospital and 12 of them had a prolonged ICU stay (>10 Days). The patients with the Candida score ≥2.5 were 06 in numbers, of which 66.7% were having score 3 followed by one each of having score 4 and 5. Out of these 06 patients 04 received antifungal treatment. One patient with Candida score more than 03 succumbed to death without having antifungal treatment.Conclusions: Early identification of invasive candidiasis with the use of “Candida Score” in critically ill patients may help to initiate antifungal interventions and even help the treating physician or intensivist to formulate the more effective treatment algorithms.
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Churata-Oroya, Diana Eugenia, Donald Ramos-Perfecto, Hilda Moromi-Nakata, Elba Martínez-Cadillo, Américo Castro-Luna i Ruth Garcia-de-la-Guarda. "Efecto antifúngico del Citrus paradisi “toronja” sobre cepas de Candida albicans aisladas de pacientes con estomatitis subprotésica". Revista Estomatológica Herediana 26, nr 2 (18.08.2016): 78. http://dx.doi.org/10.20453/reh.v26i2.2869.
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Objetivos: Determinar la actividad antifúngica in vitro del aceite esencial de Citrus paradisi “toronja” sobre cepas de Candida albicans aislados de pacientes con diagnóstico de estomatitis subprotésica. Material y métodos: Se realizaron pruebas de sensibilidad por el método de difusión en agar con pozos. La cepa de Candida albicansse obtuvo de muestras de hisopado de mucosa de pacientes con estomatitis subprotésica y se identifi có por medio de las características morfológicas de sus colonias y la prueba de tubo germinativo. El inóculo fue estandarizado al 0,5 de la escala de Mc Farland y sembrado en 12 placas con agar dextrosa sabouraud. Se hicieron pozos con un sacabocado de 6 mm de diámetro, se depositaron 50 μL de las diferentes concentraciones del aceite esencialy se procedió a la incubación en aerobiosis a 37 °C por 48 horas. El análisis estadístico se realizó con el programa SPSS Versión 23. Resultados: Las concentraciones al 25; 12,5; 6,25; 3,13 y 1,56 % presentaron un halo de inhibición promedio de 12,6; 10,3; 7,8 y 6,8 y 6,3 mm respectivamente, mientras que al 0,78 y 0,39 % no presentaron actividad antifúngica. La CMI promedio para Candida albicans fue de 6,25 %.v/v Se realizó la prueba de Kruskal Wallis y se determinó que existe diferencia estadísticamente signifi cativa p < 0,05 de promedios entre las concentraciones. Conclusiones: Se determinó que el aceite esencial de Citrus paradisi “toronja”, presentaactividad antifúngica sobre cepas de Candida albicans.
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Burduniuc, O. S., E. I. Bîrcă, A. M. Burduniuc, M. V. Bivol i O. S. Iacon. "Analysis of Сandida species distribution isolated from women with vulvovaginal candidiasis and their antifungal susceptibility profile". Health of Society 9, nr 6 (19.04.2021): 225–29. http://dx.doi.org/10.22141/2306-2436.9.6.2020.226952.
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Background. Candida species is usually a commensal fungus residing in the vagina, in about 30 %–50 % of healthy adults and remains the most common agent isolated from clinical samples of patients diagnosed with vulvovaginal candidiasis (VVC). Culture is not recommended for all patients on a routine basis but is informative for the exclusion of non-albicans infections resistant to azoles, or recurrent VVC. Identification of Candida species and antifungal susceptibility testing are key elements in the correct management of recurrent VVC. The authors of this paper aimed to study the spectrum of pathogenic Candida species. The antifungal sensitivity patterns of the isolated strains during the years 2017-2019 are also presented. Material and methods. A descriptive study of Candida species distribution and antifungal susceptibility profile was performed. Identification of isolated Candida species was performed by the MALDI-TOF MS, bacterial strains by Vitek 2 automated system (BioMérieux) and antifungal susceptibility profiles by Fungitest (Bio-Rad). Results. Of the 1030 recovered strains, C. albicans species predominated - 83.8% and Candida non albicans -16.2%. The most common species of the Candida non-albicans, were C.glabrata (7.5%). Also, it was observed that in 56.6% of the cases C. albicans presented bacterial associations. The most common microbial association was C. albicans and S.aureus (26.6%), followed by C. albicans and E.coli (20.8%). Candida spp. showed moderate antifungal resistance. The resistance rate of C. albicans isolates to miconazole, fluconazole and itraconazole was 25.5%, 17.0% and 11.4% compared to non-albicans Candida strains which showed a resistance rate of 10,8%, 14.4% and 10%, respectively. Conclusions. C. albicans is the most frequently isolated species among patients with VVC, but there is also an increase share of non-albicans Candida species such as C. glabrata. C. albicans isolates showed higher indices of resistance, than Candida non-albicans.
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Klotz, Stephen A., Mubashir Zahid, William R. Bartholomew, Pedro M. Revera i Salim Butrus. "Candida albicans". Cornea 15, nr 1 (styczeń 1996): 102???104. http://dx.doi.org/10.1097/00003226-199601000-00020.
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Eagle, Kim, i David M. Phillips. "Candida albicans". New England Journal of Medicine 328, nr 18 (6.05.1993): 1322. http://dx.doi.org/10.1056/nejm199305063281807.
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Witek-Janusek, Linda, Cynthia Cusack i Herbert L. Mathews. "Candida albicans". Dimensions of Critical Care Nursing 17, nr 5 (wrzesień 1998): 243–55. http://dx.doi.org/10.1097/00003465-199809000-00002.
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Wilson, Duncan. "Candida albicans". Trends in Microbiology 27, nr 2 (luty 2019): 188–89. http://dx.doi.org/10.1016/j.tim.2018.10.010.
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Berman, Judith. "Candida albicans". Current Biology 22, nr 16 (sierpień 2012): R620—R622. http://dx.doi.org/10.1016/j.cub.2012.05.043.
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Thompson, June. "Candida albicans". Primary Health Care 7, nr 9 (1.10.1989): 8. http://dx.doi.org/10.7748/phc.7.9.8.s11.
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Ln, Khandare, i Barate Dl. "INCIDENCES OF CANDIDA ALBICANS AND NON-ALBICANS AMONG CATHETER-ASSOCIATED URINARY TRACT INFECTION PATIENTS OF AKOLA CITY". Asian Journal of Pharmaceutical and Clinical Research 10, nr 11 (1.11.2017): 115. http://dx.doi.org/10.22159/ajpcr.2017.v10i11.19769.
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Objective: Candida spp. is the third leading cause of catheter-related infections. Candida species is a part of human microflora and it becomes pathogenic when certain conditions are present and cause an opportunistic infections. The present study was undertaken to determine incidences of Candida albicans and non-albicans among catheterized urinary tract infection (UTI) patients of Akola city.Methods: A total 60 catheter urine samples were collected from patient of all the age group and both sex who had indwelling urinary catheter. The collected catheterized urine samples of patients from various hospitals of Akola city were used for isolation using HiCrome Candida differential agar.Results: It was found that highest frequency of isolation of Candida spp. was from age group 61-70 years. The predominance of male candidate was more than female having Candida spp. in catheter-associated UTI (C-UTI). Among the Candida spp. C. albicans (64.81%) was predominant over non-albicans spp. while in non-albicans Candida krusei and Candida glabrata were predominant showing 11.11% incidences. It was followed by Candida tropicalis (9.2%) and Candida parapsilosis (3.7%).Conclusion: The incidences of C. albicans and non-albicans were high among catheter-associated UTI patients.
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Raj Kumari, Sanjana, i Neetu Adhikaree. "Speciation of Candida using CHROMagar from various clinical specimens and their antifungal susceptibility pattern at a tertiary care hospital." Journal of College of Medical Sciences-Nepal 16, nr 2 (8.07.2020): 107–11. http://dx.doi.org/10.3126/jcmsn.v16i2.29896.
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Background: Candida albicans remains the most common and are responsible for various clinical infections ranging from mucocutaneous infection to life threatening invasive diseases. But recent epidemiological data shift from C.albicans to non albicans Candida species and also increased resistance to antifungal drugs made the scenario a serious concern.
Methods: A total of 156 Candida isolates from various clinical specimens received in the department of Microbiology were taken up for the study over a period of one year i.e. from March 2019 to February 2020. The Candida were grown on Sabouraud dextrose agar to be evaluated for colony appearance, macroscopic examination, Gram staining, germ tube, urea hydrolysis etc. The Candida isolates were speciated by using CHROMagar medium. Antifungal susceptibility testing was performed as recommended by Clinical and Laboratory Standards Institute (CLSI) M44-A document.
Results: The isolation of non albicans Candida (54.5%) predominated over Candida albicans (45.5%). Non albicans Candida isolated were Candida tropcalis 40(25.6%), Candida krusei 21(13.4%), Candida glabrata 17(10.8%) and Candida dublinensis 07(4.4%) each. Candida species were all susceptible to Amphotericin B, followed by fluconazole (67.4%), miconazole (51.9%) and ketoconazole (22.5%).
Conclusions: The accurate species identification of Candida is important for the treatment because not all species respond to the same treatment and also because of the increasing antifungal resistance. CHROMagar is a convenient and rapid method of identification of Candida species specially in resource limited poor settings.
Keywords: antifungal susceptibility testing; Candida albicans; CHROMagar; non albicans Candida
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Bakhtiari, Sedigheh, Soudeh Jafari, Jamileh Bigom Taheri, Tahereh Sadat Jafarzadeh Kashi, Zahra Namazi, Maryam Iman i Mohammad Poorberafeyi. "The The Effects of Cinnamaldehyde (Cinnamon Derivatives) and Nystatin on Candida Albicans and Candida Glabrata". Open Access Macedonian Journal of Medical Sciences 7, nr 7 (10.04.2019): 1067–70. http://dx.doi.org/10.3889/oamjms.2019.245.
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BACKGROUND: Candida species are the most common opportunistic fungal infections. Today, cinnamon plants have been considered for anti-Candida properties.
AIM: This study aimed to investigate the effectiveness of cinnamaldehyde extract (from cinnamon derivatives) on Candida albicans and Candida glabrata species and comparison with nystatin.
MATERIAL AND METHODS: In this study, cinnamaldehyde and nystatin were used. The specimens included Candida albicans and Candida glabrata. Minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were measured for each one by the microdilution method. This experiment was repeated three times.
RESULTS: Cinnamaldehyde extract at a concentration of 62.5 μl/ml was able to prevent the growth of Candida albicans, at a concentration of 93.7 μl/ml, causing Candida albicans to disappear, at 48.8 μl/ml, to prevent the growth of Candida glabrata, and in the concentration of 62.5 μl/ml, causes the loss of Candida glabrata. In comparison, nystatin at 0.5 μg/ml concentration prevented the growth of Candida albicans, at concentrations of 1 μg/ml causing Candida albicans to be destroyed, at 4 μg/ml concentration to prevent the growth of Candida glabrata, and at a concentration of 8 μg/ml causes the loss of Candida glabrata. The results were the same every three times.
CONCLUSIONS: Although cinnamaldehyde extract had an effect on fungal growth in both Candida albicans and Candida glabrata with a fatal effect; the effect on these two species was lower than nystatin.
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Masoumizadeh, Mahnaz, Mahboobeh Madani, Soheil Fatahian i Pegah Shakib. "Effect of Silver Nanoparticles (AgNPs) on Candida Albicans, Candida Dubliniensis and Candida Guilliermondii". Current Drug Therapy 17, nr 1 (luty 2022): 50–55. http://dx.doi.org/10.2174/1574885517666220221093456.
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Background: Candida species are the most important fungal pathogens and are sometimes considered the fourth most common cause of infection in hospitals. Today, research needs to be conducted on the antifungal effect of silver nanoparticles (AgNPs) due to toxicity, side effects, and drug interactions of antifungal chemical drugs. Objective: Therefore, this study was conducted to evaluate the antifungal activity of AgNPs on Candida albicans, Candida dubliniensis, and Candida guilliermondii. Methodology: Antifungal activity of AgNPs on Candida albicans, Candida dubliniensis, and Candida guilliermondii was assessed by agar and macrodilution diffusion methods in an in-vitro investigation. Structural changes were investigated by scanning electron microscope (SEM). Then, the obtained data were evaluated by SPSS statistical software. Results: Based on the results, the mean diameter of growth inhibition halos by AgNPs was equal to 20, 20.2, and 40.7mm for Candida albicans, Candida dubliniensis, and Candida guilliermondii, respectively. The minimum inhibitory concentrations (MIC) equal 62.50, 31.25, and 15.62 mg/ml for Candida albicans, Candida dubliniensis, and Candida guilliermondii, respectively. The minimum fungicidal concentrations (MFC) were equal to 125, 62.50, and 31.25 mg/ml for Candida albicans, Candida dubliniensis, and Candida guilliermondii, respectively. Conclusion: Our results revealed that AgNPs inhibit the growth of Candida albicans, Candida dubliniensis, and Candida guilliermondii. SEM observations also showed that NPs disrupted cell membrane/wall. Changes in yeast levels from smooth to uneven were also observed.
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Marchamtia Sarah Nur Awalia Fajari i Muhammad Taufiq Qurrohman. "EFEKTIVITAS VARIASI KONSENTRASI TEPUNG TALAS SEBAGAI MEDIA ALTERNATIF PERTUMBUHAN JAMUR Candida albicans". Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) 2, nr 2 (1.10.2021): 185–97. http://dx.doi.org/10.53699/joimedlabs.v2i2.56.
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Tepung talas memiliki nilai karbohidrat 70-80%. Sumber karbohidrat yang tinggi ini berpotensi dimanfaatkan dalam bentuk media alternatif untuk mendukung pada pemeriksaan kultur jamur Candida albicans. Candida albicans merupakan salah satu jamur yang menyebabkan Kandidiasis. Penelitian ini bertujuan untuk melihat efektivitas variasi konsentrasi tepung talas sebagai media alternatif terhadap pertumbuhan jamur Candida albicans. Jenis penelitian adalah eksperimental. Hasil menyatakan bahwa rerata pertumbuhan koloni pada masing-masing media beda secara signifikan. Pada uji efektifitas semua konsentrasi tepung talas memiliki persentase lebih dari 100%. Terdapat pengaruh variasi tepung talas terhadap pertumbuhan jamur Candida albicans. Semakin tinggi konsentrasi media tepung talas maka semakin banyak jumlah koloni Candida albicans yang tumbuh. Pada uji efektivitas menunjukkan bahwa pada semua konsentrasi tepung talas dalam kriteria sangat efektif.
Kata kunci : tepung talas, media alternatif, Candida albicans
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Alves, Sydney Hartz, Carlos Eduardo Linares, Érico Silva de Loreto, Magnus Rodrigues, Diego I. Thomazi, Felipe Souza i Janio M. Santurio. "Utilização do ágar suco de tomate (ágar V8) na identificação presuntiva de Candida dubliniensis". Revista da Sociedade Brasileira de Medicina Tropical 39, nr 1 (luty 2006): 92–93. http://dx.doi.org/10.1590/s0037-86822006000100020.
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Avaliou-se a capacidade do ágar suco de tomate (ágar V8) em diferenciar Candida dubliniensis de Candida albicans com base na produção de clamidoconídios. Noventa e três isolados de Candida albicans e vinte e seis de Candida dubliniensis foram incluídos; 100% de Candida dubliniensis formaram clamidoconídios e 92,5% de Candida albicans não evidenciaram estas estruturas. Estes resultados permitem sugerir este meio como recurso alternativo na identificação presuntiva de Candida dubliniensis.
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ÖZTÜRK, Ali, i Ayşe KALKANCI. "Investigation of Antifungal Activities of Some Disinfectants on Candida albicans". Mikrobiyoloji Bulteni 52, nr 4 (1.10.2018): 376–89. http://dx.doi.org/10.5578/mb.67402.
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