Gotowe bibliografie tematyczne / Cancer – Molecular aspects

Gotowa bibliografia na temat „Cancer – Molecular aspects”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 29 lipca 2024

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Artykuły w czasopismach na temat "Cancer – Molecular aspects"

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Amorim, Gelbert Luiz Chamon do Carmo, Denny Fabricio Magalhães Veloso, José Carlos Vieira i Paulo Roberto Alves. "Molecular aspects of bladder cancer". Einstein (São Paulo) 9, nr 1 (marzec 2011): 95–99. http://dx.doi.org/10.1590/s1679-45082011rb1593.

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ABSTRACT One of the most important objectives of genetic markers of cancer will be the possible identification of individuals at greatest risk in order to allow better management and prognosis. Many urological tumors were associated to various types of gene alterations with a great number of genes involved in the process, hindering gene therapy. This treatment uses specific techniques and one or several genes are manipulated in the laboratory in order to induce molecular alterations that may block the oncogenic process. The article addresses these issues emphasizing the importance of the new molecular biology techniques.
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Tong, Xiao W., Dirk G. Kieback, Rajagopal Ramesh i Scott M. Freeman. "MOLECULAR ASPECTS OF OVARIAN CANCER". Hematology/Oncology Clinics of North America 13, nr 1 (luty 1999): 109–33. http://dx.doi.org/10.1016/s0889-8588(05)70156-8.

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Cronauer, M. V., i Z. Culig. "Molecular aspects of prostate cancer". World Journal of Urology 30, nr 3 (7.03.2012): 277–78. http://dx.doi.org/10.1007/s00345-012-0853-x.

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Kausch, I., i A. Böhle. "Molecular Aspects of Bladder Cancer". European Urology 41, nr 1 (styczeń 2002): 15–29. http://dx.doi.org/10.1016/s0302-2838(01)00007-0.

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Wenham, Robert M., Johnathan M. Lancaster i Andrew Berchuck. "Molecular aspects of ovarian cancer". Best Practice & Research Clinical Obstetrics & Gynaecology 16, nr 4 (sierpień 2002): 483–97. http://dx.doi.org/10.1053/beog.2002.0298.

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Hynes, Nancy, i Robert B. Dickson. "Molecular aspects of breast cancer". Journal of Mammary Gland Biology and Neoplasia 1, nr 2 (kwiecień 1996): 137–38. http://dx.doi.org/10.1007/bf02013637.

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Hecht, Jonathan L., i George L. Mutter. "Molecular and Pathologic Aspects of Endometrial Carcinogenesis". Journal of Clinical Oncology 24, nr 29 (10.10.2006): 4783–91. http://dx.doi.org/10.1200/jco.2006.06.7173.

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Endometrial cancer is the most common gynecological malignancy, with 41,000 new cases projected in the United States for 2006. Two different clinicopathologic subtypes are recognized: the estrogen-related (type I, endometrioid) and the non–estrogen-related types (type II, nonendometrioid such as papillary serous and clear cell). The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy and p53 mutations. This article reviews the genetic aspects of endometrial carcinogenesis and progression. We will define the precursor lesion of type I endometrioid cancer and the role of genetics and estrogen in its progression.
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Krasteva, M., Sv Angelova i Zl Gospodinova. "Molecular-Genetic Aspects of Breast Cancer". Acta Medica Bulgarica 41, nr 2 (1.12.2014): 67–79. http://dx.doi.org/10.1515/amb-2014-0024.

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Summary Breast cancer is the most frequent malignancy among women. Advances in breast cancer knowledge have deciphered the involvement of a number of tumor suppressor genes and proto-oncogenes in disease pathogenesis. These genes are part of the complex biochemical pathways, which enable cell cycle control and maintenance of genome integrity. Their function may be disrupted as a result of alterations in gene sequence or misregulation of gene expression including alterations in DNA methylation pattern. The present review summarizes the main findings on major breast cancer related genes BRCA1/2, p53, ATM, CHEK2, HER2, PIK3CA and their tumorigenic inactivation/activation. The potential clinical importance of these genes with respect to patients’ prognosis and therapy are also discussed. The possible implication of other putative breast cancer related genes is also outlined. The first elaborate data on the genetic and epigenetic status of the above mentioned genes concerning Bulgarian patients with the sporadic form of the disease are presented. The studies indicate for a characteristic mutational spectrum in some of the genes for the Bulgarian patients and specific correlation between the status of different genes and clinicopathological characteristics.
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Tsikouras, Panagiotis, Sofia Bouchlariotou, Nikolaos Vrachnis, Alexandros Dafopoulos, Georgios Galazios, Roland Csorba i Georg Friedrich von Tempelhoff. "Endometrial cancer: molecular and therapeutic aspects". European Journal of Obstetrics & Gynecology and Reproductive Biology 169, nr 1 (lipiec 2013): 1–9. http://dx.doi.org/10.1016/j.ejogrb.2013.01.018.

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Yashina, D. P., i Z. A. Afanasyeva. "Molecular genetic aspects of adrenocortical cancer". Advances in Molecular Oncology 10, nr 2 (10.07.2023): 42–57. http://dx.doi.org/10.17650/2313-805x-2023-10-2-42-57.

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Adrenocortical cancer is a rare tumor originating from cortical adrenal cells, endowed with aggressive potential, a rapidly progressing course and an unfavorable prognosis. The complexity of early diagnosis of the disease is due to several factors: the variability of clinical manifestations associated with the initial multiregulatory influence of steroid hormones on the body’s homeostasis, the rare occurrence of the tumor and, as a result, the lack of understanding of the molecular mechanisms of its carcinogenesis.The increased interest in recent years among oncologists and endocrinologists in understanding the fundamental and clinical aspects of adrenocortical cancer and the search for potential targets for new drugs has led to a detailed study of the cellular and molecular genetic mechanisms involved in normal adrenal ontogenesis and their role in tumor transformation. This review presents the currently known molecular genetic processes and their mediating auto-, para-, endocrine factors involved in normal adrenal ontogenesis and carcinogenesis. The paper analyzes results of trials published in international and Russian journals on molecular oncology and endocrinology indexed in the PubMed, CyberLeninka, Web of Science, Science Direct and eLIBRARY databases.
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Rozprawy doktorskie na temat "Cancer – Molecular aspects"

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Fransén, Karin. "Molecular genetic aspects of colorectal cancer development /". Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med878s.pdf.

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Hubbard, Alexandra Louise. "Some aspects of the molecular pathology of breast cancer". Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/20581.

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This thesis examines some aspects of the molecular pathology of breast cancer. Disregulation of the c-erb B2 oncogene was related to several histopathological and biochemical features of breast cancer. Other genes, specifically THRA1 and urokinase plasminogen activator were investigated for disregulation and possible interaction with c-erb B2 in the biology of breast cancer. A differential PCR technique for the detection of c-erb B2 gene amplification, was tested and validated for use on paraffin embedded methacarn fixed breast cancer tissues. Tissues from 314 breast cancers and 43 control samples were assessed for c-erb B2 gene amplification by dPCR. In clinical material the results were not affected by the DNA contribution of normal tissue elements or by cancer DNA ploidy change. C-erb B2 gene amplification was detected in 55% of invasive cancers and in 66% of in situ cancers. C-erb B2 protein overexpression in breast cancer cells, as determined by specific immunohistochemistry, was only detected in 11% of invasive cancers and 43% of in situ cancers. Comparisons show that a substantial number of cancers with c-erb B2 amplification lack detectable protein overexpression. The nature of c-erb B2 gene disregulation in breast cancer appears to be complex and multiple combinations of biological events are suggested. A model for the involvement of c-erb B2 in breast cancer progression is proposed. Mechanisms of c-erb B2 gene amplification and interaction with other cellular proteins are discussed.
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黃鳳如 i Fung-yu Huang. "Molecular and cytogenetic analysis of cervical and vulvar cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B26662188.

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Kee, Francis, i 紀思思. "Molecular pathology of hepatocellular carcinoma". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40203785.

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Webster, Lucy R. "Diagnostic molecular profiling of ductal carcinoma in situ of the breast". Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28109.

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The introduction of population-based mammographic screening has led to a dramatic increase in the diagnosis of ductal carcinoma in situ (DCIS) of the breast; with DCIS now accounting for approximately 25-35% of all screen-detected breast cancers. Epidemiological, histopathological and molecular studies have provided compelling evidence to support the notion that DCIS is a direct precursor of invasive cancer; although such data also indicate that DCIS represents a highly heterogeneous group of lesions. Some women with DCIS will develop life-threatening invasive cancer, whereas others may not. Currently, determination of the malignant potential of an individual DCIS lesion is very difficult, making selection of optimal treatment from the range of options available challenging. Histopathology has long been used to classify invasive breast tumours into biologically relevant sub-classes; although for DCIS there is still no universally accepted histological grading system. In recent years, gene expression profiling of invasive breast cancer has demonstrated that superior classification, prognostication and prediction can be achieved. Therefore, the principal aim of this study was to use classic histopathology and contemporary molecular biological methods to better classify DCIS lesions according to their inherent malignant potential. A significant difficulty in studying in situ breast cancer is a lack of rational endpoints against which potential markers can be judged; consequently initial studies were directed at identifying a rational surrogate end-point for use in subsequent molecular studies. Through the examination of a large cohort of screen-detected breast cancers, we demonstrated that the grade of concomitant invasive breast cancer was the best surrogate end-point to examine the malignant potential of in situ disease due to its direct relationship with breast cancer biology and established correlation with breast cancer survival. Another significant limitation to molecular studies of DCIS is the heterogeneity of breast tissue and the small size and limited extent of in situ lesions. Therefore, in this thesis laser capture microdissection and nucleic acid amplification techniques were successfully optimised and applied to a well-characterised cohort of DCIS lesions and adjacent areas of pre-malignant and benign epithelium. Gene expression profiling analysis of this cohort of laser capture microdissected samples was successfully performed on 36K oligonucleotide microarrays. Supervised analysis was used to identify genes differentially expressed between DCIS lesions associated with grade 1 and grade 3 invasive cancer. The “DCIS discriminative gene list” comprised 173 oligonucleotide probes and according to the relative expression of the top 100 genes samples were clustered into two biologically relevant groups. In addition, a gene expression grade index (GGI) was calculated and using a defined cut-point the DCIS lesions were classified into the same “low” and “high” molecular grade groups that had highly significant correlations with histopathologic and biological factors including DCIS nuclear grade, cell polarisation, necrosis, ER, PR, HERZ, p53 and Ki67. Further support for the clinical relevance of the gene expression derived DCIS classification was provided by the strong correlation between the molecular grade groups and both disease-free and overall survival in two independent invasive breast cancer cohorts. lmportantly, work described in this thesis also demonstrated that the gene-expression derived classification can be closely approximated using a combination of routinely available features including DCIS nuclear grade and accurate Ki67 scoring of the in situ component; thus offering a novel, biologically significant and clinically useful DCIS classification system. Results from array-based comparative genomic hybridisation (aCGH) analyses further supported the biological relevance of the gene-expression derived classification and identified potential candidate chromosomal regions underlying the variable malignant potential of in situ breast cancer.
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Wang, Yue, i 王悦. "Molecular analysis of mitochondrial DNA alterations in endometrial carcinomas". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B32059127.

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陳君怡 i Kwan-yi Queeny Chan. "Molecular studies on endometrial and ovarian carcinogenesis". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634474.

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Chan, Kwan-yi Queeny, i 陳君怡. "Molecular study of pi-class glutathione-S-transferase in endometrial carcinoma". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29157717.

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Liao, Xiaoyun, i 廖晓耘. "Hedgehog signaling pathway and epigenetic studies in ovarian carcinomas and endometrial carcinomas". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41290367.

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Butler, Lisa Maree. "Molecular analysis of the human Fas gene in colorectal cancer /". Title page, contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phb9858.pdf.

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Książki na temat "Cancer – Molecular aspects"

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Das, Undurti N. Molecular Biochemical Aspects of Cancer. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0741-1.

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Macdonald, F. Molecular biology of cancer. Wyd. 2. London: Taylor & Francis, 2004.

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K, Cowell John, red. Molecular genetics of cancer. Wyd. 2. Oxford: Bios, 2001.

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Andrzej, Mackiewicz, i Sehgal Pravinkumar B, red. Molecular aspects of cancer and its therapy. Basel: Birhäuser Verlag, 1998.

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Mackiewicz, A., i P. B. Sehgal, red. Molecular Aspects of Cancer and its Therapy. Basel: Birkhäuser Basel, 1998. http://dx.doi.org/10.1007/978-3-0348-8946-9.

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Jacqueline, Boultwood, i Fidler Carrie, red. Molecular analysis of cancer. Totowa, N.J: Humana Press, 2002.

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Minna, John D. Molecular genetics of lung cancer. [Bethesda, Md?]: National Cancer Institute, Office of Cancer Communications, 1988.

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Minna, John D. Molecular genetics of lung cancer. [Bethesda, Md?]: National Cancer Institute, Office of Cancer Communications, 1988.

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International Meeting on Molecular Staging on Cancer (1st 2001 Klinicum Grosshadern). Molecular staging of cancer. Berlin: Springer-Verlag, 2003.

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International Meeting on Molecular Staging on Cancer (1st 2001 Klinicum Grosshadern). Molecular staging of cancer. Berlin: Springer-Verlag, 2003.

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Części książek na temat "Cancer – Molecular aspects"

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Francis, Gary L. "Molecular Aspects of Thyroid Cancer in Children". W Thyroid Cancer, 33–39. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1007/978-1-59259-995-0_4.

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Bauer, Andrew J., i Gary L. Francis. "Molecular Aspects of Thyroid Cancer in Children". W Thyroid Cancer, 31–41. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3314-3_4.

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Sobti, R. C., S. Sharma, A. K. Janmeja i S. K. Jindal. "Molecular Pathogenesis of Lung Cancer". W Some Aspects of Chromosome Structure and Functions, 193–205. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-010-0334-6_18.

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Sobti, R. C., Khadijeh Onsory, Adnan Issa AL-Badran, S. K. Sharma i Harsh Mohan. "Molecular Genetics of Prostate Cancer". W Some Aspects of Chromosome Structure and Functions, 225–35. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-010-0334-6_20.

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McSherry, Elaine A., Mark B. Owens i Ann M. Hopkins. "The Molecular Aspects of Tight Junctions". W Cancer Metastasis - Biology and Treatment, 1–27. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6028-8_1.

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Das, Undurti N. "Introduction to Genes, Oncogenes, and Anti-oncogenes". W Molecular Biochemical Aspects of Cancer, 1–40. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0741-1_1.

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Das, Undurti N. "Introduction to Free Radicals, Antioxidants, Lipid Peroxidation, and Their Effects on Cell Proliferation". W Molecular Biochemical Aspects of Cancer, 41–65. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0741-1_2.

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Das, Undurti N. "Immune System, Inflammation, and Essential Fatty Acids and Their Metabolites in Cancer". W Molecular Biochemical Aspects of Cancer, 67–157. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0741-1_3.

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Das, Undurti N. "PUFAs and Their Metabolites in Carcinogenesis". W Molecular Biochemical Aspects of Cancer, 159–79. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0741-1_4.

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Das, Undurti N. "Molecular Mechanism of Anti-cancer Action of PUFAs with Particular Reference to GLA in Glioma". W Molecular Biochemical Aspects of Cancer, 181–206. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0741-1_5.

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Streszczenia konferencji na temat "Cancer – Molecular aspects"

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Cherdyntseva, N., N. Litviakov, F. Ivanova, E. Denisov, P. Gervas i E. Cherdyntsev. "The molecular aspects of personalized anticancer treatment". W PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS (PC’16): Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. Author(s), 2016. http://dx.doi.org/10.1063/1.4960229.

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"Molecular Aspects of Colorectal Cancer Prognosis in 10 years". W 4th Riau Medical Scientific and Expo 2022. Galaxy Science, 2022. http://dx.doi.org/10.11594/nstp.2022.2806.

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Thomas, Nancy E. "Abstract CN12-05: Molecular aspects of melanoma". W Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Dec 6–9, 2009; Houston, TX. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1940-6207.prev-09-cn12-05.

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Williamson, Chad, Terry Glauser, Mazi Abdolrasulnia i Andrew Sanchez. "Current Perceptions Of Oncologists Regarding Molecular Aspects Of Non-Small Cell Lung Cancer Management". W American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3056.

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Kolitz, Sarah E., Kevin D. Fowler, Peter J. King, Benjamin J. Zeskind i Brett M. Hall. "Abstract P254: Transcriptional effects in C26 tumor highlight mechanistic aspects of a novel dual MEK inhibitor, IMM-1-104". W Abstracts: AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; October 7-10, 2021. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1535-7163.targ-21-p254.

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Ferreira, Nancy, Darley Ferreira i Thais Ferreira. "GENETIC EVALUATION OF MICROCALCIFICATIONS AS A PROGNOSTIC FACTOR". W Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2101.

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Introduction: Breast cancer is the most recurring type of cancer among women, with reduced mortality at an initial stage of lesion. From a radiological perspective, perceived microcalcifications may be associated with histological findings such as proliferative injuries with or without atypical features and ductal carcinoma in situ. Currently, percutaneous and vacuum biopsies allow for the correlation between anatomoradiological and identification of previous lesions and those that offer the risk of cancer. No biomarker has been established to predict the risk of cancer in women diagnosed with benign mammary disease. Doing so could strengthen the possibility of stratifying the individual risk of benign injuries for cancer. The platelet-derived growth factor receptor A (PDGFRA) plays its part in tumor oncogenesis, angiogenesis, and metastasis, and its activation is found in some kinds of cancer. In contrast, DNA methylation standards are initial changes to the development of cancer and may be helpful in its early identification, being regulated by a family of enzymes called DNMTs (DNA methyltransferase). Methods: The aim of this study was to evaluate the profile of BI-RADS® 4 and 5 mammary microcalcification women carriers and determine the level of the gene expression of possible molecular markers in 37 patients with mammary microcalcification (paraffin blocks) and 26 patients with breast cancer (fresh in RNA later tissue) cared for at the Hospital Barão de Lucena’s Mastology Ambulatory. Anatomoradiological aspects along with clinical findings have been evaluated , and percentage rates have been calculated. The PDGFRA and DNMTs (DMNT3a) gene expressions have been established using quantitative polymerase chain reaction (qPCR), with the use of β-actin as reference gene. Discussion: In the patients with mammary microcalcification, the average age was 55.9; predominantly whiteskinned subjects (p<0.014). Most of them were mothers (p<0.001), and the average menarche age was 13. The subgroups that presented greater significance were patients classified BI-RADS® in category IV (67.6%) and histological findings of nonproliferative lesion (p<0.001). Lesions of the ductal carcinoma in situ type (100%) presented positive estrogen and progesterone receptors, and 94.6% have undergone sectorectomy surgery by prior needling (p<0.001). The most damaged breast was the left one (62.2%), and the most affected quadrant was the top lateral one (59.5%) (p<0.001). There was no family history in 83.8% of the cases. In the tested microcalcification samples, it was not possible to observe the expression of PDGFRA. Nevertheless, 15 out of 37 patients with microcalcification showed an increase in the gene expression of DMNT3a, most of them greater than Luminal and triple-negative cancer types. Conclusion: The data presented here highlight the improvement on the description of BI-RADS® 4 subclassification in order to better conduct the clinical decision and also demonstrated the potential of DNMTs evaluation in microcalcification samples as a strategy to access the understanding about the role of these molecules in the breast cancer development.
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Silva, Gabriela Calado, Denise Sobral Viana, Cecilia Souza Avila Pessoa i Erich Roberto Santos da Costa Filho. "DESCRIPTIVE EPIDEMIOLOGICAL PROFILE OF PATIENTS WITH HER2-POSITIVE METASTATIC BREAST CANCER SUBMITTED TO PERTUZUMAB AND TRASTUZUMAB AT THE CANCER HOSPITAL OF PERNAMBUCO". W XXIV Congresso Brasileiro de Mastologia. Mastology, 2022. http://dx.doi.org/10.29289/259453942022v32s1024.

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Introduction: HER2-positive breast cancer is characterized by a hyperexpression or gene amplification of human epidermal growth factor receptor 2, a tyrosine kinase membrane receptor that has a profile with major aggressiveness and worse prognosis among all molecular subtypes. The metastatic pattern of this disease is one of the greatest challenges in mastology and requires an urgency and effective therapeutics to control this disease. Advances in therapy have allowed more specific treatments for anti-HER2 treatment that allowed improvement in the overall survival and disease-free survival of patients. Double-block therapy, performed by using Trastuzumabe and Pertuzumabe, is the first-line treatment for metastatic HER2-positive breast cancer. This kind of therapy was initially adopted effectively by SUS in 2019. Therefore, it is advisable to consider the use of this therapy at the Cancer Hospital of Pernambuco (HCP) to analyze the current results in patients and assess the local results. Objective: The goal of this study was to understand the epidemiological profile of patients with HER2-positive metastatic breast cancer treated at the HCP and submitted to double-block therapy with Trastuzumab and Pertuzumab, analyzing progression-free survival and overall survival. Methods: This is a retrospective descriptive study conducted in November 2021. Relevant aspects of treatment, analysis of disease-free survival, and overall survival were analyzed in the medical records of patients with metastatic HER2-positive breast cancer who used Trastuzumab and Pertuzumab. The survey of the analyzed data was carried out by completing a specific form created by the researcher especially for this study. Anonymity and clarity of the information were ensured. Results: From 124 selected medical records, this study selected 78 patients with metastatic HER2 breast cancer, with a mean age of 50.4 years; 62.34% had positive hormone receptors and 44.87% had metastasis de novo. About 36% of patients had been using double-block for up to 6 months, which made it difficult to assess the behavior of the disease from medical examinations and images, given the short time; but it was found that of all patients, 15.4% have disease stability, 32.1% had regression, and 28.2% had disease progression. There was a median of 12 months for disease progression, but with a median of 11 months of use of double-block therapy with Trastuzumab and Pertuzumab. As for the overall survival, it is estimated, based on statistical data from the current sample, that an accumulated probability of death of up to 16.7% in up to 5 years. Women older than 60 years and those who had disease progression had a higher risk of death. Conclusion: This study evaluated metastatic HER2-positive breast cancer as a particular behavior tumor. The patients selected from the HCP submitted to the use of Trastuzumab and Pertuzumab in the metastatic scenario have a follow-up time still recent, which causes incipient data for the evaluation of specific outcomes that depend on the temporal component. Follow-up and updates of the analysis of outcomes are suggested, in the near future, to enrich the treatments proposed for the target population. Ethical aspect: This study was conducted strictly based on the Resolutions 510/16 and 416/12 of the Health National Council and was only conducted after HCP Research Ethics Committee approval.
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Boni, Arthur A., Steven J. Davis i David I. Rosen. "Mechanistic and diagnostic aspects of photodynamic enhancement and stone fragmentation". W International Laser Science Conference. Washington, D.C.: Optica Publishing Group, 1986. http://dx.doi.org/10.1364/ils.1986.fe4.

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Metastable oxygen molecules in the singlet delta state, O2(1Δ), are believed to be the active species that are produced during laser irradiation of hematoporphyrin derivative (HPD), attached to tumors, and are responsible for cancer cell destruction. Although the presence of O2(1Δ) has been inferred by indirect chemical measurements, it has not been detected in real time. In this work, we review the optical characteristics of O2(1Δ) and describe an optical diagnostic procedure for its real-time detection during laser irradiation. In vitro experiments using both pulsed and cw dye lasers are described. Additionally, recent work has been presented whereby repetitively pulsed dye laser radiation can be delivered through a fiber-optic probe to induce fragmentation of kidney stones and gallstones.
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Al-Atieh, Noor, Salma Ahmad, Hanan Nazar i Allal Ouhtit. "Anti-cancer properties of Microalgae (T1) Extract in Breast Cancer Cell Lines". W Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0154.

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Breast cancer (BC), a worldwide health issue, is the most common malignant cancer in women in Gulf region, including the State of Qatar. Unfortunately, malignant tumors has the capability to metastasis, which involves both migration and invasion of cancer cells which are the most threatening aspects of cancer (McSherry et al., 2007). Consequently, researchers have concentrated on Complementary and Alternative medicine (CAM) modalities, as conventional medicine has been facing various challenges such as; poor understanding of the mechanisms with BC proliferation and invasion within various groups of patients, drug resistance, and the failure of current therapies to completely cure the disease. A significant CAM method have been raised which is the treatment with herbs and extracts derived from seeds, leaves, fruits and roots of plants; each of these invariably represents a combination of several bioactive compounds. Our biofuel has provided us with a crude extract of a microalgae coded as T1 that consist of carotenoids, chlorophyll a, and chlorophyll b. Carotenoids is a bioactive molecule that inhibits the proliferation, migration, invasion and induce apoptosis to tumor cells.
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Nosiri, Chidi I., Chukwuma Anyanwu, Wisdom U. Ike, Ifeoma J. Okpara i Caleb J. Nwaogwugwu. "Computational Screening of an Isolated HerbalCcompound, Carveol on GPC-1 Protein Receptors in Prostate Cancer: A Molecular Docking Study". W ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.083.941580.

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