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Artykuły w czasopismach na temat "Broken cell serving"
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Fankhauser, Reilly, Matthew Chang, Zachary Garrison, Rachel Berryman, Olivia M. Lucero, Allison Fuiten, Nicholas DePatie, Hilary Seifert i Rajan P. Kulkarni. "Single-Cell Identification of Melanoma Biomarkers in Circulating Tumor Cells". Cancers 14, nr 19 (8.10.2022): 4921. http://dx.doi.org/10.3390/cancers14194921.
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The current standard for investigating tumors is surgical biopsy, which is costly, invasive, and difficult to perform serially. As an adjunct, circulating tumor cells (CTCs)—cells that have broken away from the primary tumor or metastatic sites—can be obtained from a blood draw and offer the potential for obtaining serial genetic information and serving as biomarkers. Here, we detail the potential for melanoma CTCs to serve as biomarkers and discuss a clinically viable methodology for single-cell CTC isolation and analysis that overcomes previous limitations. We explore the use of melanoma CTC biomarkers by isolating and performing single-cell RNA sequencing on CTCs from melanoma patients. We then compared transcriptional profiles of single melanoma CTCs against A375 cells and peripheral blood mononuclear cells to identify unique genes differentially regulated in circulating melanoma tumor cells. The information that can be obtained via analysis of these CTCs has significant potential in disease tracking.
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Malyuchenko, N. V., E. Yu Kotova, O. I. Kulaeva, M. P. Kirpichnikov i V. M. Studitskiy. "PARP1 Inhibitors: Antitumor Drug Design". Acta Naturae 7, nr 3 (15.09.2015): 27–37. http://dx.doi.org/10.32607/20758251-2015-7-3-27-37.
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The poly (ADP-ribose) polymerase 1 (PARP1) enzyme is one of the promising molecular targets for the discovery of antitumor drugs. PARP1 is a common nuclear protein (1-2 million molecules per cell) serving as a sensor for DNA strand breaks. Increased PARP1 expression is sometimes observed in melanomas, breast cancer, lung cancer, and other neoplastic diseases. The PARP1 expression level is a prognostic indicator and is associated with a poor survival prognosis. There is evidence that high PARP1 expression and treatment-resistance of tumors are correlated. PARP1 inhibitors are promising antitumor agents, since they act as chemo- and radiosensitizers in the conventional therapy of malignant tumors. Furthermore, PARP1 inhibitors can be used as independent, effective drugs against tumors with broken DNA repair mechanisms. Currently, third-generation PARP1 inhibitors are being developed, many of which are undergoing Phase II clinical trials. In this review, we focus on the properties and features of the PARP1 inhibitors identified in preclinical and clinical trials. We also describe some problems associated with the application of PARP1 inhibitors. The possibility of developing new PARP1 inhibitors aimed at DNA binding and transcriptional activity rather than the catalytic domain of the protein is discussed.
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Klein, Barrett A., i M. Kathryn Busby. "Slumber in a cell: honeycomb used by honey bees for food, brood, heating… and sleeping". PeerJ 8 (5.08.2020): e9583. http://dx.doi.org/10.7717/peerj.9583.
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Sleep appears to play an important role in the lives of honey bees, but to understand how and why, it is essential to accurately identify sleep, and to know when and where it occurs. Viewing normally obscured honey bees in their nests would be necessary to calculate the total quantity and quality of sleep and sleep’s relevance to the health and dynamics of a honey bee and its colony. Western honey bees (Apis mellifera) spend much of their time inside cells, and are visible only by the tips of their abdomens when viewed through the walls of an observation hive, or on frames pulled from a typical beehive. Prior studies have suggested that honey bees spend some of their time inside cells resting or sleeping, with ventilatory movements of the abdomen serving as a telltale sign distinguishing sleep from other behaviors. Bouts of abdominal pulses broken by extended pauses (discontinuous ventilation) in an otherwise relatively immobile bee appears to indicate sleep. Can viewing the tips of abdomens consistently and predictably indicate what is happening with the rest of a bee’s body when inserted deep inside a honeycomb cell? To distinguish a sleeping bee from a bee maintaining cells, eating, or heating developing brood, we used a miniature observation hive with slices of honeycomb turned in cross-section, and filmed the exposed cells with an infrared-sensitive video camera and a thermal camera. Thermal imaging helped us identify heating bees, but simply observing ventilatory movements, as well as larger motions of the posterior tip of a bee’s abdomen was sufficient to noninvasively and predictably distinguish heating and sleeping inside comb cells. Neither behavior is associated with large motions of the abdomen, but heating demands continuous (vs. discontinuous) ventilatory pulsing. Among the four behaviors observed inside cells, sleeping constituted 16.9% of observations. Accuracy of identifying sleep when restricted to viewing only the tip of an abdomen was 86.6%, and heating was 73.0%. Monitoring abdominal movements of honey bees offers anyone with a view of honeycomb the ability to more fully monitor when and where behaviors of interest are exhibited in a bustling nest.
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Foulkes, Daniel M., Dominic P. Byrne, Fiona P. Bailey i Patrick A. Eyers. "Tribbles pseudokinases: novel targets for chemical biology and drug discovery?" Biochemical Society Transactions 43, nr 5 (1.10.2015): 1095–103. http://dx.doi.org/10.1042/bst20150109.
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Tribbles (TRIB) proteins are pseudokinase mediators of eukaryotic signalling that have evolved important roles in lipoprotein metabolism, immune function and cellular differentiation and proliferation. In addition, an evolutionary-conserved modulation of PI3K/AKT signalling pathways highlights them as novel and rather unusual pharmaceutical targets. The three human TRIB family members are uniquely defined by an acidic pseudokinase domain containing a ‘broken’ α C-helix and a MEK (MAPK/ERK)-binding site at the end of the putative C-lobe and a distinct C-terminal peptide motif that interacts directly with a small subset of cellular E3 ubiquitin ligases. This latter interaction drives proteasomal-dependent degradation of networks of transcription factors, whose rate of turnover determines the biological attributes of individual TRIB family members. Defining the function of individual Tribs has been made possible through evaluation of individual TRIB knockout mice, siRNA/overexpression approaches and genetic screening in flies, where the single TRIB gene was originally described 15 years ago. The rapidly maturing TRIB field is primed to exploit chemical biology approaches to evaluate endogenous TRIB signalling events in intact cells. This will help define how TRIB-driven protein–protein interactions and the atypical TRIB ATP-binding site, fit into cellular signalling modules in experimental scenarios where TRIB-signalling complexes remain unperturbed. In this mini-review, we discuss how small molecules can reveal rate-limiting signalling outputs and functions of Tribs in cells and intact organisms, perhaps serving as guides for the development of new drugs. We predict that appropriate small molecule TRIB ligands will further accelerate the transition of TRIB pseudokinase analysis into the mainstream of cell signalling.
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Djulbegovic, Benjamin, Athanasios Tsalatsanis, Rahul Mhaskar, Iztok Hozo, Branko Miladinovic i Howard Tuch. "Improving Hospice Referral: Application of Regret-Based Decision Modeling at End-of-Life Care". Blood 128, nr 22 (2.12.2016): 535. http://dx.doi.org/10.1182/blood.v128.22.535.535.
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Abstract Introduction: Terminally ill patients are often faced with the decision to forgo potentially life-prolonging treatment or to accept hospice care leading to a peaceful death. The decision process in such situations is heavily affected by emotions, chief among them is regret. Modern cognitive science increasingly accepts a dual processing approach to human cognition which takes into account both emotion-based (type 1) and analytical-based (type 2) cognitive processing. Because regret is a human emotion (type 1), which involves counterfactual deliberations (type 2), we have previously proposed that it can activate both cognitive domains by serving as a link between type 1 and type 2 processes and therefore help with end of life decisions more precisely than other decision making methodologies. Here, we report the application of a regret-based model built to facilitate referral to hospice while helping patients clarify their preferences related to how they wish to spend the remaining days of their lives. Methods: Between March 2013 to December 2015, we conducted a prospective cohort study at the Tampa General Hospital and the Moffitt Cancer Center that enrolled 178 consecutive adult patients aware of the terminal nature of their disease. Eligible patients were those who were at the point in their care where they had to decide between continuing potentially "curative/life-prolonging" treatment (Rx) or accepting hospice care. The study was broken down into 4 steps. First, we computed the patient's probability of survival at 6 months using a validated Palliative Performance Score (PPS-based) predictive model. This probability was communicated to patients as i. percentage, ii. pictorial, and iii. life expectancy in days. Then, we used the Dual Visual Analog Scale technique (DVAS) to elicit patient preferences towards continuing current treatment vs. accepting hospice care. The first scale in DVAS measured the levels of regret of omission (RGO) (e.g. failure to reap hospice benefits and incurring treatment harms) while the second scale measured regret of commission (RGC) (e.g. incurring harms from hospice and failing to provide potential benefits of treatment). The ratio RGO/RGC was used to compute the threshold probability at which a patient is indifferent between accepting hospice care or continuing current treatment. Each patient's threshold was contrasted against the previously estimated survival probability to suggest a patient specific management plan, which was later compared with the patient's actual choice. The final step of the study involved asking each patient a series of qualitative questions to evaluate the usefulness of the regret model in the hospice referral process. Results: 96% (171/178) of the patients found the information provided by the model helpful; 90% (160/178) stated that it will influence their care decision. 85% (151/178) of the patients agreed with the model's recommendations to either accept hospice care or continue with current treatment [p<0.000001]. The regret model predicted the actual choices for 72% (128/178) of patients [p <0.00001]. Logistic regression analysis showed that people who were initially inclined to be referred to hospice and were predicted to choose hospice over disease-directed treatment by the regret model had close to 98% probability of choosing hospice care at the end of their lives. No other factors (age, gender, race, educational status and pain level) affected the patient actual choice. Conclusions: To our knowledge, this is the first formal study in which helping patient clarify their preferences enabled them to make actual choices with high level of satisfaction. The regret model was well received by patients and its recommendations were largely accepted. We found that people suffering from a terminal disease who are initially inclined to choose hospice and do not regret such a choice will select hospice care with high level of certainty. We conclude that using the regret model to elicit patient choices is both descriptively and prescriptively valid and can be easily implemented in the actual practice. Disclosures No relevant conflicts of interest to declare.
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Wiesinger, Jason, Karen Cichy, Sara Edmister, Sharon Hooper i Raymond Glahn. "An In Vitro Analysis and In Vivo Trial Demonstrating the Improved Iron Bioavailability of White Beans (Phaseolus vulgaris L.) After Processing Into Pasta". Current Developments in Nutrition 6, Supplement_1 (czerwiec 2022): 1197. http://dx.doi.org/10.1093/cdn/nzac074.026.
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Abstract Objectives The cotyledon cell wall of the common bean can be a factor in Fe bioavailability. This study evaluated the iron bioavailability of two bean varieties (white or black) either boiled (intact cell walls) or extruded into pasta formulated from heat treated bean flour as the major ingredient (100% bean flour; broken cell walls). Methods In vitro Fe bioavailability was determined via the Caco-2 Cell Bioassay. In vivo Fe bioavailability was measured by the capacity of a bean-based or bean pasta-based diet to generate and maintain total body hemoglobin iron (Hb-Fe) during a 6 week poultry feeding trial. Results The iron and phytate concentrations of the bean-based and bean pasta-based diets consisting of tomato paste, carrot, cabbage, milk, potato and corn oil were not significantly different. The Caco-2 cell bioassay predicted that the white bean pasta diet would have the highest Fe bioavailability, closely followed by the white bean diet. The bioassay predicted the black bean diet and the black bean pasta diet would have significantly lower Fe bioavailability. For the in vivo studies, animals fed the white bean pasta diet (broken cell walls) had significantly (p ≤ 0.05) higher hemoglobin, Hb-Fe and hemoglobin maintenance efficiencies than animals fed a white bean, black bean or black bean pasta-based diet. Although cotyledon cells were broken, the iron bioavailability of the black bean pasta was not improved after processing into pasta. The low iron bioavailability of black beans was associated with their high concentrations of seed coat procyanidin, cinnamtannin and anthocyanidin compounds that have a negative impact on the absorption of iron. Conclusions This study shows that white colored dry bean possesses a combination of traits that result in improved iron bioavailability after processing into pasta. The enhanced Fe bioavailability from the white bean pasta is likely due to the breakage of the cotyledon cell wall during processing, thus allowing enhanced bioaccessibility of the intracellular Fe. In the black bean pasta diet, this enhancement was not observed due to the presence of the seed coat polyphenols which interacted with the released intracellular Fe and prevented Fe absorption. Funding Sources Funded by the United States Department of Agriculture, Agricultural Research Service.
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Kanade, Prakash, i Jai Prakash Prasad. "Mobile and Location Based Service using Augmented Reality: A Review". European Journal of Electrical Engineering and Computer Science 5, nr 2 (18.03.2021): 13–18. http://dx.doi.org/10.24018/ejece.2021.5.2.303.
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MAR (Mobile Augmented Reality) is delegated an innovation that gives similar capacities as AR (Augmented Reality), yet without the actual limitations of the area of an exploration office or testing region. A Location-Based Service (LBS) is an application for portable figuring which gives clients administrations dependent on their topographical area. Area based administrations are getting progressively famous with the ascent of cell phones with an ever increasing number of highlights (particularly Apple's iPhone and Android-based gadgets). Increasingly more substance is improved with geo-information and can subsequently be seen in a virtual climate, however in real, portable conditions and in a setting delicate way fit to the requirements of the client. The definition and advantages of versatile increased reality and area based administrations and the mix of portable enlarged reality and area based administrations are broke down in this article. The issues are examined alongside the upsides and downsides.
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Monakova, Julia, Huma Tariq, Sherrie Hertz, Tom Kouroukis i Irene Blais. "Funding model for stem cell transplant." Journal of Clinical Oncology 35, nr 8_suppl (10.03.2017): 22. http://dx.doi.org/10.1200/jco.2017.35.8_suppl.22.
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22 Background: A call for development of a new model for funding Stem Cell Transplant (SCT) services in Ontario led to a costing initiative described below. The new model needed to be in alignment with current costs and clinical practices, and to avoid over or under-funding the required components of care for all types of transplant (autologous, allogeneic-related, allogeneic un-related). Methods: The patient care path was broken down by transplant type into the following phases: Pre-Transplant, Graft Harvesting or Procurement, Transplant, and Follow-Up. The following Canadian and Ontario data sources were used for fiscal year 2013/14 and 2014/15 to identify costs of care: -Case Costing data submitted by the six hospitals providing SCT services, -Discharge Abstract Database (DAD), -National Ambulatory Care Reporting System (NACRS), -Other data sources, as needed (e.g. Specialized Services Oversight Information System, Health Indicator Tool). Additionally, the costs for high cost drugs, infrastructure, psychosocial support, and pathology services components were specifically identified. Broad consultation with clinical, administrative, and costing experts ensured the data was complete and appropriate to patient care needs. Once the costs for each component and phase were estimated, the funding model was developed using the bundling approach where the costs of specific activities and/or phases were bundled together for the purposes of funding. Results: The SCT Funding Model developed based on this costing initiative consists of the following four bundles covering the continuum of a patient’s care from pre-transplant to post-transplant care follow-up: 1.) Pre-Transplant, 2.)Graft Acquisition, 3.)Transplant (includes transplant and follow-up), and 4.) High Cost Drugs. Conclusions: The new SCT Funding Model reflects up-to-date costs and addresses the gaps of the previous approach. It has been implemented and is widely supported due to the extensive stakeholder engagement throughout the process. It is an important component of provincial-level planning for SCT service delivery.
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Pathak, Vinay. "A Priority Based Efficient Secure Framework for WBANs". International Journal of Information Security and Privacy 13, nr 3 (lipiec 2019): 60–73. http://dx.doi.org/10.4018/ijisp.201907010104.
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In this article, the authors propose a system to gather patient information continuously, perform proper non-intrusive checking, and propose restorative or potentially way of life engagements, at whatever point required and proper. The structure, which depends on administration arranged service as application(SOAs) and the Cloud, permits a consistent combination of various innovations, applications, also, administrations. It additionally integrates mobile advances to easily gather, convey imperative information from a patient's wearable biosensors while considering a cell phones' restricted abilities and control seepage, notwithstanding discontinuous system detachments. At that point, information is put away in the Cloud and made accessible by means of SOA to permit access by doctors, paramedics, or other approved authorities. A contextual investigation has been created to assess the convenience of the structure, and the preparatory outcomes that have been broken down are demonstrating exceptionally encouraging outcomes. To secure the data transmission, they have applied identity-based data encryption scheme. It enhances the security in the authors' framework.
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Zeitoun, Mark, i Michael Talhami. "The impact of explosive weapons on urban services: Direct and reverberating effects across space and time". International Review of the Red Cross 98, nr 901 (kwiecień 2016): 53–70. http://dx.doi.org/10.1017/s1816383117000157.
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AbstractThis article reviews the factors that determine the impact of explosive weapons on urban services in space and time, with a focus on drinking water services. The evidence comes from published and unpublished research and records, as well as experience restoring or maintaining such services. Urban services are seen as interconnected, and each composed of interdependent components of people, consumables and hardware. Elements that make up the components are labelled “upstream”, “midstream” and “downstream”, to reflect their location and hierarchy in the production and delivery of any urban service. The impact of explosive weapons is broken into the direct effects on any of the components of a service, and the reverberating effects on up- and or downstream components of the same service, or on other services. The effects are most commonly observed in service infrastructure, and determined chiefly by the extent of the damage to the functionality of any component. The spatial extent of the impact is found to be determined primarily by the hierarchy of the component suffering the direct impact, with attacks on upstream components being the furthest-reaching. The duration of the impact is determined primarily by the pre-explosion “baseline resilience” of the service, itself a function of system redundancies and emergency preparedness and response. The analysis suggests that the impact is more reasonably foreseeable than may commonly be thought, in the sense that the direct effects of explosives are well known and that the most important infrastructure is generally identifiable. It follows that proportionality assessments which involve urban services would benefit from (i) the direct and consistent engagement of specialized engineers within the targeting cell, and (ii) greater familiarity of the weapons controller with services, infrastructure and systems in urban areas.
Rozprawy doktorskie na temat "Broken cell serving"
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VATS, PREETI. "RELAXED MUTUAL EXCLUSION ALGORITHM IN MOBILE CELLULAR NETWORK". Thesis, 2016. http://dspace.dtu.ac.in:8080/jspui/handle/repository/14753.
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ABSTRACT
Now a days, Mobile computing networks revolutionize the way computers are used.
Mobile hosts have small memory, a relatively slow processor and low power batteries,
and communicate over low bandwidth wireless communication links. Distributed
dynamic channel allocation in mobile cellular networks and other similar structures is a
fundamental resource management problem. It has aroma of distributed mutual exclusion
but is not exactly mutual exclusion problem because a channel must be reused in different
cells. Existing mutual exclusion algorithms for cellular systems are not suitable to mobile
systems due to above limitations. Here, the exact relation being established between the
both algorithms. Specifically, we describe the procedure of relaxed mutual exclusion to
modularize the problem of distributed channel allocation.
A geographical area is divided into hexagonal cells, every cell uses the same
bandwidth, which is divided into channels. Cell phone must use one channel to make a
call. Cells have different traffic usage of channels such that every cell could need
different quantity of channels. Allocation algorithm should dynamically allocate
channels (resources) to cells, to get the most efficient usage of available bandwidth
using relaxed mutual exclusion. We propose a general algorithm that guarantees
relaxed mutual exclusion for a single resource, prove a necessary and sufficient
condition for the information structure, and address the issues that arise in relaxed
mutual exclusion, including deadlock resolution, dealing with multiple resources, and
design of efficient information structure. Here, improvement based on mutual
exclusion solution, such as deadlock minimization and broken cells serving extended
to multiple channel case is described to an extent to use the bandwidth efficiently.
Keywords : Relaxed Mutual Exclusion, channel allocation, deadlock minimization,
broken cell serving, TSDP(Two-Step Dynamic-Priority), borrowing scheme
Części książek na temat "Broken cell serving"
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Jankowicz-Cieslak, Joanna, Florian Goessnitzer, Bradley J. Till i Ivan L. Ingelbrecht. "Induced Mutagenesis and In Vitro Mutant Population Development in Musa spp." W Efficient Screening Techniques to Identify Mutants with TR4 Resistance in Banana, 3–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 2022. http://dx.doi.org/10.1007/978-3-662-64915-2_1.
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AbstractMutagenesis of in vitro propagated bananas is an efficient method to introduce novel alleles and broaden genetic diversity. Mutations can be induced by treatment of plant cells with chemical mutagens or ionizing radiation. The FAO/IAEA Plant Breeding and Genetics Laboratory established efficient methods for mutation induction of in vitro shoot tips in banana using physical and chemical mutagens as well as methods for the efficient discovery of EMS-induced single nucleotide mutations in targeted genes or amplicons and identification of large genomic changes, including deletions and insertions. Mutagenesis of in vitro propagated tissues requires large populations serving as starting material, and a long process to dissolve genetic mosaics (chimeras) resulting from the mutagenesis of multicellular tissues. However, treating shoot apical meristems of tissue cultured bananas with a mutagen is a commonly used practice for banana mutation breeding programmes, and still the most effective. In our previous studies, we showed that chimeras, unique mutations accumulated in different cells of the plant propagule, could be rapidly removed via isolation of shoot apical meristems and subsequent longitudinal bisection. Further, induced mutations were maintained in mutant plants for several generations. We established such systems for inducing and maintaining both point mutations caused via EMS mutagenesis as well as insertions and deletions caused by gamma irradiation and describe hereafter methods for dose selection, gamma irradiation and chimera dissolution.
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Carey, John. "Damned to Fame: The Life of Samuel Beckett; Samuel Beckett: The Last Modernist; The World of Samuel Beckett, 1906–1946". W Sunday Best, 183–87. Yale University Press, 2022. http://dx.doi.org/10.12987/yale/9780300266689.003.0050.
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This chapter discusses the legacy of Samuel Beckett as presented in the works of James Knowlson, Anthony Cronin, and Lois Gordon. The Second World War changed Beckett, since he joined the Resistance after returning to Paris when the war broke out. Beckett's war service and voluntary work in the early months of peace in a Red Cross hospital in Normandy brought him closer to ordinary people. Beckett's job consisted of typing and translating for an intelligence-gathering cell belonging to the British Special Operations Executive. The chapter notes that Gordon depicted Beckett's interest as being focused more on politics than initially believed. Meanwhile, Cronin's work elaborated on Beckett's tangled sex life.
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Talita Santos Silva, Karla, Cinthia Moreira de Araújo Melo, Taysa Cristina Cardoso Freitas, Sylmara Corrêa Monteiro, Weslane Almeida Cavalcanti Magalhães, Valdenice Ferreira dos Reis, Ricardo Otávio Maia Gusmão i Rene Ferreira da Silva Junior. "Penile cancer profile in patients residing in Minas Gerais". W Estudos Interdisciplinares em Ciências da Saúde, 156–58. Editora Acadêmica Periodicojs, 2022. http://dx.doi.org/10.51249/easn05.2022.843.
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Objective: to describe the profile of patients with penile cancer. Methods: descriptive study with a quantitative approach. Clinical and epidemiological data of individuals with penile cancer residing in the state of Minas Gerais were evaluated. Inclusion criteria were data available in the system and incomplete data were excluded. An analysis of the data available in the hospital records of the Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA) was carried out in the most recent historical series, and a descriptive analysis of the data was performed. The study was carried out during the month of June 2022. Results: 573 cases of penile cancer were identified in the state of Minas Gerais in the historical series investigated. Most patients were between 50 and 74 years old (60.3%), 52.3% considered themselves brown and 36.1 white, the most common schooling was incomplete elementary school (53.4%), in married civil servant (56.0%), being the occupation as agricultural worker the most predominant (28.9%). The highest prevalence was squamous cell carcinoma (78.3%), accompanied by squamous cell carcinoma “in situ” (7.3%). In the TNM classification, the most frequent staging was 99 (50.0%), with surgery being the most commonly used therapeutic modality (60.3%). Conclusion: men with penile cancer were older, were married, brown and had a low level of education, often being agricultural workers. Being the most advanced carcinogenesis and the most commonly used surgery.
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Clay, Daniel L., i T. David Elkin. "Training in Pediatric Psychosocial Hematology/Oncology". W Comprehensive Handbook of Childhood Cancer and Sickle Cell Disease. Oxford University Press, 2006. http://dx.doi.org/10.1093/oso/9780195169850.003.0038.
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As evidenced by the chapters in this book, psychosocial hematology/oncology (hem/onc) presents a wide array of complex problems and issues for the patients, their families, and the health care team. Because the diseases are unpredictable and often life-threatening, treating the whole child effectively requires a multidisciplinary team of health care professionals working in concert to address the physical, emotional, and spiritual needs of affected families. Working effectively on such a team requires specialized training to manage disease-specific issues such as pain, complexities of multidisciplinary work, and the stress resulting from working with severe and sometimes terminal illnesses. In general, there are many complex roles for psychosocial service providers in the delivery of health care (Brown et al., 2002), and for these reasons, the roles in the hem/onc setting can be even more important and complex. The purposes of this chapter are to (a) describe the phases of training, (b) discuss issues that have an impact on the training process, and (c) describe key content areas in which training is necessary to reach an acceptable level of competence for working in the area of psychosocial hem/onc. Although the team members consist of various health care professionals and subspecialties such as physicians, nurses, dieticians, psychologists, and social workers, this chapter focuses on graduate and postdoctoral training of psychosocial service providers such as psychologists, social workers, and counselors. However, many of the issues we discuss also apply to training in the other professions at both the preservice and postgraduate levels. This chapter consists of two main sections: the first section deals with the process of training, and the second addresses the content of specialized training in hem/onc. The first section begins with a detailed description of training that incorporates a developmental model of knowledge and skill acquisition. We then discuss current trends that have a direct impact on the implementation of training methods and the settings in which clinical training takes place. The second section includes a description of several content areas specific to the needs of patients and health care staff working in hem/onc. These areas address specific knowledge and skill domains and the methods by which these domains can be integrated into the training model.
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"Neighbours, as Reg Watson said, was the softest concept he had ever come up with, and he thinks the success of the show worldwide is the softness; whereas in this country when you’re dealing with a foreign accent in a soft premise, you have a tougher row to hoe. (Cristal 1992) Here, Cristal touches on the second, and major, incompatibility between Neighbours and the US mediascape: its foreignness. He elaborates: The real problem . . . is that the American marketplace – and I don’t agree with it, but so be it – is, has been anti-foreign material for as long as I can remember . . . . The one show that broke through – and it was on a network – was Prisoner with Patrick McGoohan. (Cristal 1991) Variety, more hard-nosed in its trade prognostications than the more “newsy,” advertorially-oriented commentaries cited above, frankly notes that “it’s questionable whether [Neighbours] will achieve the level of runaway success it’s found elsewhere . . . . International pop–cultural exchange seems to be one-sided for the US, which is generally xenophobic about embracing fare from other nations” (“Gray.” 1991: 72; this rare acknowledgement of American media ethnocentrism does not, of course, undercut Variety’s servicing role in relation to the US media’s domestic and overseas markets). The Americanization of non-American film and television is big business. Hollywood versions of foreign film successes as varied as The Vanishing and La Cage aux Folles represent a significant proportion of Hollywood production. One sizable company, Don Tafler International, specializes in Americanizing foreign television programs. Till Death Do Us Part is a major example of a foreign program which “had to be remade . . . because the original was not acceptable in this country . . . and yet Archie Bunker, All In The Family . . . which was a direct lift from that show . . . became a classic in our country” (Cristal 1992). Grundy’s themselves supported the sequelling and Americanization of Prisoner: Cell Block H with Dangerous Women, an American production with Peter Pinne as its executive producer. If the Patrick McGoohan Prisoner was exceptional in its status of being foreign material which gained entrance to the fiercely ethnocentric US television networks, few more successes have been registered with independent stations. The bulk of such material – and overall there is precious little of it – finds its way into the US market by way of the more upmarket route of public service television, most of whose imports are British, largely genteel and respectable, though extending to include EastEnders. With this point in mind, Cristal remarked: “I would think that Neighbours, in retrospect, might have been more appropriate to a public broadcaster” (Cristal 1992). In the year of Neighbours’s attempt on the US market, public service television screened The Shiralee and Dolphin Cove, and Bangkok Hilton was shown on cable. This is a". W To Be Continued..., 120. Routledge, 2002. http://dx.doi.org/10.4324/9780203131855-22.
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Tian, Xiaotong, i Yichen Wu. "Investigating the concept of sustainable strategy in digital service design". W 14th International Conference on Applied Human Factors and Ergonomics (AHFE 2023). AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1003365.
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In the new era of rapid economic development, human beings are beginning to think about whether a sustainable development path can be built between humans, nature, and society. Simultaneously, the digital society has increased the number of digital services that users encounter in their daily lives and the emergence of more virtual digital products. In this study, we propose a strategy to investigate the concept of sustainability in the design of digital services by working with companies and using a case study of shattered cell phone screen insurance. The large amount of e-waste generated by users' constant use and constant replacement of consumer electronics has not received the attention it deserves.Therefore, we will focus on applying and exploring the sustainability concept in digital services and exploring inspirational design in broken screen insurance services to convey the sustainability concept to users.In the first phase, this study interprets the design case of the sustainable concept through case studies, with desktop research used to analyze the qualitative content of the inherent status of e-waste in policy and implementation. Questionnaire research was conducted to collect data on users' experiences of e-waste generated by cell phones as a carrier of broken screen insurance services, using data secondary analysis to elicit user trust patterns for new products and concepts. We created a mind map centered on sustainable environmental protection, emotional interaction design, and e-waste, and defined the user needs for each of the three major areas. The framework of the digital service tandem based on the concept of sustainable screen-shattering insurance was established to demonstrate the different types of environmental design that can be incorporated at different stages of user contact with screen-shattering insurance. In the second phase, based on the design framework of the first phase, the functional architecture of the shattered screen insurance service design is organized. The interaction model of the online digital service is conceived, specifically visualizing the process of each link and designing the interaction form. According to research and practice, the design of digital services must be socially attractive, functional, and easy to understand in order to increase retention rates. This helps to increase public awareness of sustainability concepts and allows users to build a deeper awareness of environmental protection, thus enhancing the communication strategy of sustainability concepts in digital services.
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Li, Mengli, Weiqiang Wang i Aiju Li. "Study on the Microstructure of 20 Steel With Strain Aging". W ASME 2011 Pressure Vessels and Piping Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/pvp2011-57302.
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20 steel thick-wall high-pressure pipes are widely used in chemical industry in China, but brittle fracture accidents of them happen frequently in recent years. The strain aging steel pipes in this research were artificially made in the laboratory and naturally occurred in fabrication or service. The microstructure of strain aging in samples taken from the unused pipes and the accident pipes caused directly or mainly by strain aging were observed with optical microscopy, scanning electron microscopy, and transmission electron microscopy. The results show that: (1)uniform ferrite and pearlite with uniform lamellar structure can be achieved with normalizing; lamellar pearlite fractures and distorts while a large number of dislocation cells, micro-holes or cracks appear in material after strain aging; and broken distorted pearlite changes to uniform spherical structure after stress relieving; (2) both the samples taken from unused and accident pipes which strain aging artificially in the laboratory and naturally in fabrication or service have the same characteristics as following: the basic changes of microstructure after strain aging cannot be observed with optical microscopy, but can be observed with scanning electron microscopy and transmission electron microscopy.