Rozprawy doktorskie na temat „BRCA testing”
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Sprawdź 23 najlepszych rozpraw doktorskich naukowych na temat „BRCA testing”.
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Pack, Jessica K. B. A. "The Impact of the Myriad Direct-to-Consumer Advertising Campaign for BRCA1/2 Genetic Testing in the Greater Cincinnati Area". University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1311692006.
Pełny tekst źródłaFerlatte, Christy. "Patient preferences for an appropriate time for cancer genetic counseling and BRCA testing for women diagnosed with breast cancer". Waltham, Mass. : Brandeis University, 2009. http://dcoll.brandeis.edu/handle/10192/23193.
Pełny tekst źródłaChristopher, Juleen L. "An Examination of Dimensions of Perceived Behavioral Control Regarding Genetic Counseling and Testing for BRCA 1 and BRCA 2 in African-American Women at Moderate to High-Risk for Breast Cancer". Diss., Virginia Tech, 2010. http://hdl.handle.net/10919/77364.
Pełny tekst źródłaPh. D.
Chadwell, Sarah E. B. S. "Factors Influencing Clinical Follow-up for Individuals with a Personal History of Breast and/or Ovarian Cancer and Previous Negative or Uncertain BRCA1 and BRCA2 Testing". University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1491317215551797.
Pełny tekst źródłaElliott, Diana. "The impact of genetic counselling for familial breast cancer on women's psychological distress, risk perception and understanding of BRCA testing". University of Western Australia. School of Population Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0190.
Pełny tekst źródłaArver, Brita. "Hereditary breast/ovarian cancer : implementation of BRCA1 & BRCA2 testing /". Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4799-6/.
Pełny tekst źródłaKeenan, Lisa A. "Family Environment, Social Support, and Psychological Distress of Women Seeking BRCA1 and BRCA2 Genetic Mutation Testing". Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3240/.
Pełny tekst źródłaDoughty, Courtney R. "Retrospective Comparison of In-person versus Telephone Results Disclosure Counseling for BRCA1/2 Genetic Testing". University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1211940755.
Pełny tekst źródłaLesniak, Karen. "Psychological and Sociodemographic Predictors of Psychological Distress in BRCA1 and BRCA2 Genetic Testing Participants within a Community Based Genetic Screening Program". Thesis, University of North Texas, 2000. https://digital.library.unt.edu/ark:/67531/metadc2565/.
Pełny tekst źródłaColtri, Julia Anne. "Transgender male patients and hereditary breast cancer risk: broaching difficult topics to reduce healthcare disparities". The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555683611281611.
Pełny tekst źródłaBajdik, Christopher Douglas. "Family history of breast/ovarian cancer and referral criteria for a BRCA1 testing program". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61058.pdf.
Pełny tekst źródłaSuzuki, Ayaka. "Familial Communication of Positive BRCA1/2 Genetic Testing Results: A Relational Dialectics Theory Approach". University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504787059498275.
Pełny tekst źródłaChivers, Seymour Kimberley-Clair. "Talking to relatives about genetic testing for BRCA1/2 and its risk implications : an on-going discussion". Thesis, University of Southampton, 2013. https://eprints.soton.ac.uk/354118/.
Pełny tekst źródłaVan, Tassel William Edward. "An evaluation of pocket-model, numerical readout breath alcohol testing instruments". Texas A&M University, 2003. http://hdl.handle.net/1969.1/1159.
Pełny tekst źródłaSkates, Steven J., Mark H. Greene, Saundra S. Buys, Phuong L. Mai, Powel Brown, Marion Piedmonte, Gustavo Rodriguez i in. "Early detection of ovarian cancer using the risk of ovarian cancer algorithm with frequent CA125 testing in women at increased familial risk-combined results from two screening trials". American Association for Cancer Research, 2017. http://hdl.handle.net/10150/625973.
Pełny tekst źródłaHolmes, Christina Patrice. "You're armed, I think you're better armed, women's opinions of genetic counselling and testing for hereditary breast and ovarian cancer susceptibility (BRCA1)". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0009/MQ52793.pdf.
Pełny tekst źródłaGibbons, Deborah Kay. "“It's Not Only About Them:“ Female Family Members' Understanding of Indeterminate Negative BRCA1/2 Test Results". BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7701.
Pełny tekst źródłaWilliams-Jones, Bryn. "Genetic testing for sale : implications of commercial BRCA testing in Canada". Thesis, 2002. http://hdl.handle.net/2429/13580.
Pełny tekst źródłaMaheu, Christine. "Interpreting and making sense of uninformative results of testing for BRCA 1 and BRCA 2 cancer gene mutations". Thesis, 2005. http://hdl.handle.net/2429/17030.
Pełny tekst źródłaApplied Science, Faculty of
Nursing, School of
Graduate
Ozakinci, Gozde. "Psychological and behavioral outcomes of genetic testing for BRCA1/2 mutations among Ashkenazi Jewish Women /". 2004. http://wwwlib.umi.com/dissertations/fullcit/3153612.
Pełny tekst źródłaMoura, Ana Luísa Pinto da Silva Lobo Peixoto de. "Spectrum of BRCA1 and BRCA2 germline mutations in Portuguese Hereditary Breast and Ovarian cancer: ancestral origin of founder mutations and their implications for genetic testing criteria and strategy". Tese, 2019. https://hdl.handle.net/10216/122595.
Pełny tekst źródłaMoura, Ana Luísa Pinto da Silva Lobo Peixoto de. "Spectrum of BRCA1 and BRCA2 germline mutations in Portuguese Hereditary Breast and Ovarian cancer: ancestral origin of founder mutations and their implications for genetic testing criteria and strategy". Doctoral thesis, 2019. https://hdl.handle.net/10216/122595.
Pełny tekst źródłaMagro, Tatiana Natália Tavares. "Testing the combinatory use of PARP1 and RPA inhibitors in breast cancer cell lines". Master's thesis, 2019. http://hdl.handle.net/10773/29527.
Pełny tekst źródłaA perda do supressor tumoral BRCA2 está fortemente associada ao cancro da mama. O BRCA2 é essencial para a recombinação homóloga, que é uma via de reparação de ADN crucial para a estabilidade genómica. Quando as células sofrem mutações neste gene, elas não conseguem reparar os danos no ADN através da recombinação homóloga, que é uma via de reparação precisa, e em vez disso, tornam-se dependentes de vias alternativas, propensas a erros, para reparação de ADN. Deste modo, as células tumorais mutantes para BRCA2 tornam-se dependentes destas vias alternativas para sobreviverem. A geração mais recente de terapias direcionadas são os inibidores da PARP1. A PARP1 é uma proteína essencial para a iniciação de várias vias de reparação de ADN, incluindo as tais vias de reparação alternativas, como a non-homologous end joining (NHEJ). A utilização destes inibidores compromete as vias alternativas levando à morte das células tumorais. Embora as células tumorais mutantes para BRCA2 sejam particularmente sensíveis aos inibidores da PARP1, o aparecimento da resistência tumoral tem sido observado frequentemente após tratamentos de longo-prazo. Este problema motivou-nos a procurar proteínas alternativas cuja inibição prejudicasse especificamente, à semelhança da PARP1, a viabilidade e/ou crescimento das células tumorais. Foi recentemente reportado que o BRCA2 regula a transcrição da ARN polimerase II e previne a formação de R-loops, que são estruturas de ácidos nucleicos de 3 cadeias compostas por híbridos de ADN:ARN. A acumulação destes R-loops está implicada no processo de carcinogénese devido à acumulação de ADN de cadeia simples (do inglês ssDNA) e ao aumento de instabilidade genómica. O RPA é uma proteína que se liga ao ssDNA e evita que se formem estruturas secundárias, sendo crucial para a replicação e reparação de ADN. O nosso objetivo é identificar novos alvos terapêuticos cuja inibição possa ser usada em combinação ou como alternativa aos inibidores da PARP1, minimizando o risco de resistência tumoral. A nossa hipótese de trabalho é que a inibição combinatória de PARP1 e RPA aumentará especificamente a perda de viabilidade das células de cancro da mama.
Mestrado em Biomedicina Molecular