Artykuły w czasopismach: „Brain-age prediction”

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Xiong, Min, Lan Lin, Yue Jin, Wenjie Kang, Shuicai Wu i Shen Sun. "Comparison of Machine Learning Models for Brain Age Prediction Using Six Imaging Modalities on Middle-Aged and Older Adults". Sensors 23, nr 7 (30.03.2023): 3622. http://dx.doi.org/10.3390/s23073622.

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Machine learning (ML) has transformed neuroimaging research by enabling accurate predictions and feature extraction from large datasets. In this study, we investigate the application of six ML algorithms (Lasso, relevance vector regression, support vector regression, extreme gradient boosting, category boost, and multilayer perceptron) to predict brain age for middle-aged and older adults, which is a crucial area of research in neuroimaging. Despite the plethora of proposed ML models, there is no clear consensus on how to achieve better performance in brain age prediction for this population. Our study stands out by evaluating the impact of both ML algorithms and image modalities on brain age prediction performance using a large cohort of cognitively normal adults aged 44.6 to 82.3 years old (N = 27,842) with six image modalities. We found that the predictive performance of brain age is more reliant on the image modalities used than the ML algorithms employed. Specifically, our study highlights the superior performance of T1-weighted MRI and diffusion-weighted imaging and demonstrates that multi-modality-based brain age prediction significantly enhances performance compared to unimodality. Moreover, we identified Lasso as the most accurate ML algorithm for predicting brain age, achieving the lowest mean absolute error in both single-modality and multi-modality predictions. Additionally, Lasso also ranked highest in a comprehensive evaluation of the relationship between BrainAGE and the five frequently mentioned BrainAGE-related factors. Notably, our study also shows that ensemble learning outperforms Lasso when computational efficiency is not a concern. Overall, our study provides valuable insights into the development of accurate and reliable brain age prediction models for middle-aged and older adults, with significant implications for clinical practice and neuroimaging research. Our findings highlight the importance of image modality selection and emphasize Lasso as a promising ML algorithm for brain age prediction.

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Zhang, Biao, Shuqin Zhang, Jianfeng Feng i Shihua Zhang. "Age-level bias correction in brain age prediction". NeuroImage: Clinical 37 (2023): 103319. http://dx.doi.org/10.1016/j.nicl.2023.103319.

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Gómez-Ramírez, Jaime, Miguel A. Fernández-Blázquez i Javier J. González-Rosa. "Prediction of Chronological Age in Healthy Elderly Subjects with Machine Learning from MRI Brain Segmentation and Cortical Parcellation". Brain Sciences 12, nr 5 (29.04.2022): 579. http://dx.doi.org/10.3390/brainsci12050579.

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Normal aging is associated with changes in volumetric indices of brain atrophy. A quantitative understanding of age-related brain changes can shed light on successful aging. To investigate the effect of age on global and regional brain volumes and cortical thickness, 3514 magnetic resonance imaging scans were analyzed using automated brain segmentation and parcellation methods in elderly healthy individuals (69–88 years of age). The machine learning algorithm extreme gradient boosting (XGBoost) achieved a mean absolute error of 2 years in predicting the age of new subjects. Feature importance analysis showed that the brain-to-intracranial-volume ratio is the most important feature in predicting age, followed by the hippocampi volumes. The cortical thickness in temporal and parietal lobes showed a superior predictive value than frontal and occipital lobes. Insights from this approach that integrate model prediction and interpretation may help to shorten the current explanatory gap between chronological age and biological brain age.

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de Lange, Ann-Marie G., i James H. Cole. "Commentary: Correction procedures in brain-age prediction". NeuroImage: Clinical 26 (2020): 102229. http://dx.doi.org/10.1016/j.nicl.2020.102229.

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Dunås, Tora, Anders Wåhlin, Lars Nyberg i Carl-Johan Boraxbekk. "Multimodal Image Analysis of Apparent Brain Age Identifies Physical Fitness as Predictor of Brain Maintenance". Cerebral Cortex 31, nr 7 (5.03.2021): 3393–407. http://dx.doi.org/10.1093/cercor/bhab019.

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Abstract Maintaining a youthful brain structure and function throughout life may be the single most important determinant of successful cognitive aging. In this study, we addressed heterogeneity in brain aging by making image-based brain age predictions and relating the brain age prediction gap (BAPG) to cognitive change in aging. Structural, functional, and diffusion MRI scans from 351 participants were used to train and evaluate 5 single-modal and 4 multimodal prediction models, based on 7 regression methods. The models were compared on mean absolute error and whether they were related to physical fitness and cognitive ability, measured both currently and longitudinally, as well as study attrition and years of education. Multimodal prediction models performed at a similar level as single-modal models, and the choice of regression method did not significantly affect the results. Correlation with the BAPG was found for current physical fitness, current cognitive ability, and study attrition. Correlations were also found for retrospective physical fitness, measured 10 years prior to imaging, and slope for cognitive ability during a period of 15 years. The results suggest that maintaining a high physical fitness throughout life contributes to brain maintenance and preserved cognitive ability.

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Cole, James H., Robert Leech i David J. Sharp. "Prediction of brain age suggests accelerated atrophy after traumatic brain injury". Annals of Neurology 77, nr 4 (25.03.2015): 571–81. http://dx.doi.org/10.1002/ana.24367.

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Lombardi, Angela, Nicola Amoroso, Domenico Diacono, Alfonso Monaco, Sabina Tangaro i Roberto Bellotti. "Extensive Evaluation of Morphological Statistical Harmonization for Brain Age Prediction". Brain Sciences 10, nr 6 (11.06.2020): 364. http://dx.doi.org/10.3390/brainsci10060364.

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Characterizing both neurodevelopmental and aging brain structural trajectories is important for understanding normal biological processes and atypical patterns that are related to pathological phenomena. Initiatives to share open access morphological data contributed significantly to the advance in brain structure characterization. Indeed, such initiatives allow large brain morphology multi-site datasets to be shared, which increases the statistical sensitivity of the outcomes. However, using neuroimaging data from multi-site studies requires harmonizing data across the site to avoid bias. In this work we evaluated three different harmonization techniques on the Autism Brain Imaging Data Exchange (ABIDE) dataset for age prediction analysis in two groups of subjects (i.e., controls and autism spectrum disorder). We extracted the morphological features from T1-weighted images of a mixed cohort of 654 subjects acquired from 17 sites to predict the biological age of the subjects using three machine learning regression models. A machine learning framework was developed to quantify the effects of the different harmonization strategies on the final performance of the models and on the set of morphological features that are relevant to the age prediction problem in both the presence and absence of pathology. The results show that, even if two harmonization strategies exhibit similar accuracy of predictive models, a greater mismatch occurs between the sets of most age-related predictive regions for the Autism Spectrum Disorder (ASD) subjects. Thus, we propose to use a stability index to extract meaningful features for a robust clinical validation of the outcomes of multiple harmonization strategies.

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Kassani, Peyman Hosseinzadeh, Alexej Gossmann i Yu-Ping Wang. "Multimodal Sparse Classifier for Adolescent Brain Age Prediction". IEEE Journal of Biomedical and Health Informatics 24, nr 2 (luty 2020): 336–44. http://dx.doi.org/10.1109/jbhi.2019.2925710.

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Peng, Han, Weikang Gong, Christian F. Beckmann, Andrea Vedaldi i Stephen M. Smith. "Accurate brain age prediction with lightweight deep neural networks". Medical Image Analysis 68 (luty 2021): 101871. http://dx.doi.org/10.1016/j.media.2020.101871.

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Lam, Pradeep, Alyssa Zhu, Lauren Salminen, Sophia Thomopoulos, Neda Jahanshad i Paul Thompson. "Comparison of Deep Learning Methods for Brain Age Prediction". Biological Psychiatry 87, nr 9 (maj 2020): S374—S375. http://dx.doi.org/10.1016/j.biopsych.2020.02.959.

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Niu, Xin, Fengqing Zhang, John Kounios i Hualou Liang. "Improved prediction of brain age using multimodal neuroimaging data". Human Brain Mapping 41, nr 6 (15.04.2020): 1626–43. http://dx.doi.org/10.1002/hbm.24899.

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Valizadeh, S. A., J. Hänggi, S. Mérillat i L. Jäncke. "Age prediction on the basis of brain anatomical measures". Human Brain Mapping 38, nr 2 (3.11.2016): 997–1008. http://dx.doi.org/10.1002/hbm.23434.

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Hussain, Shah, Shahab Haider, Sarmad Maqsood, Robertas Damaševičius, Rytis Maskeliūnas i Muzammil Khan. "ETISTP: An Enhanced Model for Brain Tumor Identification and Survival Time Prediction". Diagnostics 13, nr 8 (18.04.2023): 1456. http://dx.doi.org/10.3390/diagnostics13081456.

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Technology-assisted diagnosis is increasingly important in healthcare systems. Brain tumors are a leading cause of death worldwide, and treatment plans rely heavily on accurate survival predictions. Gliomas, a type of brain tumor, have particularly high mortality rates and can be further classified as low- or high-grade, making survival prediction challenging. Existing literature provides several survival prediction models that use different parameters, such as patient age, gross total resection status, tumor size, or tumor grade. However, accuracy is often lacking in these models. The use of tumor volume instead of size may improve the accuracy of survival prediction. In response to this need, we propose a novel model, the enhanced brain tumor identification and survival time prediction (ETISTP), which computes tumor volume, classifies it into low- or high-grade glioma, and predicts survival time with greater accuracy. The ETISTP model integrates four parameters: patient age, survival days, gross total resection (GTR) status, and tumor volume. Notably, ETISTP is the first model to employ tumor volume for prediction. Furthermore, our model minimizes the computation time by allowing for parallel execution of tumor volume computation and classification. The simulation results demonstrate that ETISTP outperforms prominent survival prediction models.

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Ly, Maria, Nishita Muppidi, Helmet Karim, Gary Yu, Akiko Mizuno, William Klunk i Howard Aizenstein. "IMPROVING BRAIN AGE PREDICTION MODELS: INCORPORATION OF AMYLOID STATUS IN ALZHEIMER’S DISEASE". Innovation in Aging 3, Supplement_1 (listopad 2019): S91. http://dx.doi.org/10.1093/geroni/igz038.347.

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Abstract Brain age prediction may serve as a promising, individualized biomarker of brain health and may help us understand the heterogeneous biological changes that occur in aging. Brain age prediction is a machine learning method that estimates an individual’s chronological age from their neuroimaging scans. If predicted brain age is greater than chronological age, that individual may have an “older” brain than expected, suggesting that they may have experienced a higher cumulative exposure to brain insults or were more impacted by those pathological insults. However, contemporary brain age models include older participants with amyloid pathology in their training sets and thus may be confounded when studying Alzheimer’s disease (AD). We showed that amyloid status is a critical feature for brain age prediction models by training a model on 808 individuals without significant amyloid pathology from the ADNI, OASIS-3, and IXI cohorts. Our model accurately predicted brain age in the training and independent test sets, comparable to previous published models: [r(807) = 0.94, R2 = 0.88, p=0.001, MAE = 4.9 years, p=0.001], [r(39) = 0.67, R2 = 0.45, and MAE = 4.6 years]. We demonstrated significant differences between AD diagnostic groups [F(3,431)=30.7, p<0.001], and our model was the first to delineate significant differences in brain age relative to chronological age between cognitively normal individuals with and without amyloid [mean difference, 95% CI; CN-Aβ(-) (-3.4, -4.9:-1.8), CN-Aβ(+) (-0.7, -1.9:0.5)]. Ultimately, incorporation of amyloid status in brain age prediction models improves the utility of brain age as a biomarker for aging and AD.

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Jacob, Yael, Gaurav Verma, Sarah Rutter, Laurel Morris, Priti Balchandani i James Murrough. "P328. Brain Age Prediction Using Functional Brain Network Efficiency in Major Depressive Disorder". Biological Psychiatry 91, nr 9 (maj 2022): S220. http://dx.doi.org/10.1016/j.biopsych.2022.02.564.

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Zhao, Yihong, Arno Klein, F. Xavier Castellanos i Michael P. Milham. "Brain age prediction: Cortical and subcortical shape covariation in the developing human brain". NeuroImage 202 (listopad 2019): 116149. http://dx.doi.org/10.1016/j.neuroimage.2019.116149.

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Sun, Jiancheng, Zongqing Tu, Deqi Meng, Yizhou Gong, Mengmeng Zhang i Jinsong Xu. "Interpretation for Individual Brain Age Prediction Based on Gray Matter Volume". Brain Sciences 12, nr 11 (9.11.2022): 1517. http://dx.doi.org/10.3390/brainsci12111517.

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The relationship between age and the central nervous system (CNS) in humans has been a classical issue that has aroused extensive attention. Especially for individuals, it is of far greater importance to clarify the mechanisms between CNS and age. The primary goal of existing methods is to use MR images to derive high-accuracy predictions for age or degenerative diseases. However, the associated mechanisms between the images and the age have rarely been investigated. In this paper, we address the correlation between gray matter volume (GMV) and age, both in terms of gray matter themselves and their interaction network, using interpretable machine learning models for individuals. Our goal is not only to predict age accurately but more importantly, to explore the relationship between GMV and age. In addition to targeting each individual, we also investigate the dynamic properties of gray matter and their interaction network with individual age. The results show that the mean absolute error (MAE) of age prediction is 7.95 years. More notably, specific locations of gray matter and their interactions play different roles in age, and these roles change dynamically with age. The proposed method is a data-driven approach, which provides a new way to study aging mechanisms and even to diagnose degenerative brain diseases.

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Habeck, Christian, Qolamreza Razlighi i Yaakov Stern. "Predictive utility of task-related functional connectivity vs. voxel activation". PLOS ONE 16, nr 4 (8.04.2021): e0249947. http://dx.doi.org/10.1371/journal.pone.0249947.

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Functional connectivity, both in resting state and task performance, has steadily increased its share of neuroimaging research effort in the last 1.5 decades. In the current study, we investigated the predictive utility regarding behavioral performance and task information for 240 participants, aged 20–77, for both voxel activation and functional connectivity in 12 cognitive tasks, belonging to 4 cognitive reference domains (Episodic Memory, Fluid Reasoning, Perceptual Speed, and Vocabulary). We also added a model only comprising brain-structure information not specifically acquired during performance of a cognitive task. We used a simple brain-behavioral prediction technique based on Principal Component Analysis (PCA) and regression and studied the utility of both modalities in quasi out-of-sample predictions, using split-sample simulations (= 5-fold Monte Carlo cross validation) with 1,000 iterations for which a regression model predicting a cognitive outcome was estimated in a training sample, with a subsequent assessment of prediction success in a non-overlapping test sample. The sample assignments were identical for functional connectivity, voxel activation, and brain structure, enabling apples-to-apples comparisons of predictive utility. All 3 models that were investigated included the demographic covariates age, gender, and years of education. A minimal reference model using simple linear regression with just these 3 covariates was included for comparison as well and was evaluated with the same resampling scheme as described above. Results of the comparison between voxel activation and functional connectivity were mixed and showed some dependency on cognitive outcome; however, mean differences in predictive utility between voxel activation and functional connectivity were rather small in terms of within-modality variability or predictive success. More notably, only in the case of Fluid Reasoning did concurrent functional neuroimaging provided compelling about cognitive performance beyond structural brain imaging or the minimal reference model.

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Mazher, Moona, Abdul Qayyum, Domenec Puig i Mohamed Abdel-Nasser. "Effective Approaches to Fetal Brain Segmentation in MRI and Gestational Age Estimation by Utilizing a Multiview Deep Inception Residual Network and Radiomics". Entropy 24, nr 12 (23.11.2022): 1708. http://dx.doi.org/10.3390/e24121708.

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To completely comprehend neurodevelopment in healthy and congenitally abnormal fetuses, quantitative analysis of the human fetal brain is essential. This analysis requires the use of automatic multi-tissue fetal brain segmentation techniques. This paper proposes an end-to-end automatic yet effective method for a multi-tissue fetal brain segmentation model called IRMMNET. It includes a inception residual encoder block (EB) and a dense spatial attention (DSAM) block, which facilitate the extraction of multi-scale fetal-brain-tissue-relevant information from multi-view MRI images, enhance the feature reuse, and substantially reduce the number of parameters of the segmentation model. Additionally, we propose three methods for predicting gestational age (GA)—GA prediction by using a 3D autoencoder, GA prediction using radiomics features, and GA prediction using the IRMMNET segmentation model’s encoder. Our experiments were performed on a dataset of 80 pathological and non-pathological magnetic resonance fetal brain volume reconstructions across a range of gestational ages (20 to 33 weeks) that were manually segmented into seven different tissue categories. The results showed that the proposed fetal brain segmentation model achieved a Dice score of 0.791±0.18, outperforming the state-of-the-art methods. The radiomics-based GA prediction methods achieved the best results (RMSE: 1.42). We also demonstrated the generalization capabilities of the proposed methods for tasks such as head and neck tumor segmentation and the prediction of patients’ survival days.

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Lee, Jeyeon, Brian J. Burkett, Hoon-Ki Min, Matthew L. Senjem, Emily S. Lundt, Hugo Botha, Jonathan Graff-Radford i in. "Deep learning-based brain age prediction in normal aging and dementia". Nature Aging 2, nr 5 (maj 2022): 412–24. http://dx.doi.org/10.1038/s43587-022-00219-7.

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Cai, Huanhuan, Jiajia Zhu i Yongqiang Yu. "Robust prediction of individual personality from brain functional connectome". Social Cognitive and Affective Neuroscience 15, nr 3 (marzec 2020): 359–69. http://dx.doi.org/10.1093/scan/nsaa044.

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Abstract Neuroimaging studies have linked inter-individual variability in the brain to individualized personality traits. However, only one or several aspects of personality have been effectively predicted based on brain imaging features. The objective of this study was to construct a reliable prediction model of personality in a large sample by using connectome-based predictive modeling (CPM), a recently developed machine learning approach. High-quality resting-state functional magnetic resonance imaging data of 810 healthy young participants from the Human Connectome Project dataset were used to construct large-scale brain networks. Personality traits of the five-factor model (FFM) were assessed by the NEO Five Factor Inventory. We found that CPM successfully and reliably predicted all the FFM personality factors (agreeableness, openness, conscientiousness and neuroticism) other than extraversion in novel individuals. At the neural level, we found that the personality-associated functional networks mainly included brain regions within default mode, frontoparietal executive control, visual and cerebellar systems. Although different feature selection thresholds and parcellation strategies did not significantly influence the prediction results, some findings lost significance after controlling for confounds including age, gender, intelligence and head motion. Our finding of robust personality prediction from an individual’s unique functional connectome may help advance the translation of ‘brain connectivity fingerprinting’ into real-world personality psychological settings.

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Wang, Johnny, Maria J. Knol, Aleksei Tiulpin, Florian Dubost, Marleen de Bruijne, Meike W. Vernooij, Hieab H. H. Adams, M. Arfan Ikram, Wiro J. Niessen i Gennady V. Roshchupkin. "Gray Matter Age Prediction as a Biomarker for Risk of Dementia". Proceedings of the National Academy of Sciences 116, nr 42 (1.10.2019): 21213–18. http://dx.doi.org/10.1073/pnas.1902376116.

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The gap between predicted brain age using magnetic resonance imaging (MRI) and chronological age may serve as a biomarker for early-stage neurodegeneration. However, owing to the lack of large longitudinal studies, it has been challenging to validate this link. We aimed to investigate the utility of such a gap as a risk biomarker for incident dementia using a deep learning approach for predicting brain age based on MRI-derived gray matter (GM). We built a convolutional neural network (CNN) model to predict brain age trained on 3,688 dementia-free participants of the Rotterdam Study (mean age 66 ± 11 y, 55% women). Logistic regressions and Cox proportional hazards were used to assess the association of the age gap with incident dementia, adjusted for age, sex, intracranial volume, GM volume, hippocampal volume, white matter hyperintensities, years of education, and APOE ε4 allele carriership. Additionally, we computed the attention maps, which shows which regions are important for age prediction. Logistic regression and Cox proportional hazard models showed that the age gap was significantly related to incident dementia (odds ratio [OR] = 1.11 and 95% confidence intervals [CI] = 1.05–1.16; hazard ratio [HR] = 1.11, and 95% CI = 1.06–1.15, respectively). Attention maps indicated that GM density around the amygdala and hippocampi primarily drove the age estimation. We showed that the gap between predicted and chronological brain age is a biomarker, complimentary to those that are known, associated with risk of dementia, and could possibly be used for early-stage dementia risk screening.

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Guo, Yingying, Xi Yang, Zilong Yuan, Jianfeng Qiu i Weizhao Lu. "A comparison between diffusion tensor imaging and generalized q-sampling imaging in the age prediction of healthy adults via machine learning approaches". Journal of Neural Engineering 19, nr 1 (1.02.2022): 016013. http://dx.doi.org/10.1088/1741-2552/ac4bfe.

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Abstract Objective. Brain age, which is predicted using neuroimaging data, has become an important biomarker in aging research. This study applied diffusion tensor imaging (DTI) and generalized q-sampling imaging (GQI) model to predict age respectively, with the purpose of evaluating which diffusion model is more accurate in estimating age and revealing age-related changes in the brain. Approach. Diffusion MRI data of 125 subjects from two sites were collected. Fractional anisotropy (FA) and quantitative anisotropy (QA) from the two diffusion models were calculated and were used as features of machine learning models. Sequential backward elimination algorithm was used for feature selection. Six machine learning approaches including linear regression, ridge regression, support vector regression (SVR) with linear kernel, quadratic kernel and radial basis function (RBF) kernel and feedforward neural network were used to predict age using FA and QA features respectively. Main results. Age predictions using FA features were more accurate than predictions using QA features for all the six machine learning algorithms. Post-hoc analysis revealed that FA was more sensitive to age-related white matter alterations in the brain. In addition, SVR with RBF kernel based on FA features achieved better performances than the competing algorithms with mean absolute error ranging from 7.74 to 10.54, mean square error (MSE) ranging from 87.79 to 150.86, and normalized MSE ranging from 0.05 to 0.14. Significance. FA from DTI model was more suitable than QA from GQI model in age prediction. FA metric was more sensitive to age-related white matter changes in the brain and FA of several brain regions could be used as white matter biomarkers in aging.

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Kuo, Chen-Yuan, Pei-Lin Lee, Sheng-Che Hung, Li-Kuo Liu, Wei-Ju Lee, Chih-Ping Chung, Albert C. Yang i in. "Large-Scale Structural Covariance Networks Predict Age in Middle-to-Late Adulthood: A Novel Brain Aging Biomarker". Cerebral Cortex 30, nr 11 (23.06.2020): 5844–62. http://dx.doi.org/10.1093/cercor/bhaa161.

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Abstract The aging process is accompanied by changes in the brain’s cortex at many levels. There is growing interest in summarizing these complex brain-aging profiles into a single, quantitative index that could serve as a biomarker both for characterizing individual brain health and for identifying neurodegenerative and neuropsychiatric diseases. Using a large-scale structural covariance network (SCN)-based framework with machine learning algorithms, we demonstrate this framework’s ability to predict individual brain age in a large sample of middle-to-late age adults, and highlight its clinical specificity for several disease populations from a network perspective. A proposed estimator with 40 SCNs could predict individual brain age, balancing between model complexity and prediction accuracy. Notably, we found that the most significant SCN for predicting brain age included the caudate nucleus, putamen, hippocampus, amygdala, and cerebellar regions. Furthermore, our data indicate a larger brain age disparity in patients with schizophrenia and Alzheimer’s disease than in healthy controls, while this metric did not differ significantly in patients with major depressive disorder. These findings provide empirical evidence supporting the estimation of brain age from a brain network perspective, and demonstrate the clinical feasibility of evaluating neurological diseases hypothesized to be associated with accelerated brain aging.

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Deshpande, Prof Deepali, Shravani Bahirat, Vaisnavi Dalvi, Sakshi Darawade i Shravani Jagtap. "Brain Stroke Prediction using Machine Learning". International Journal for Research in Applied Science and Engineering Technology 11, nr 5 (31.05.2023): 1093–101. http://dx.doi.org/10.22214/ijraset.2023.51431.

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Abstract: A brain stroke, is a saviour disease in which a blood cot or bleeding occur in the brain during a stoke, which can result in long-term harm. This can affects person’s move, think, see, or communicate. The another medical name for the Brain Stroke is cerebrovascular or CVA is when The body part that the blood-starved brain cells regulate ceases to function. Brain Stroke is very critical situation as it directly leads to death or permanent disability. The stroke is classified into two areas ischemic stroke and Haemorrhagic. When blood clots re created in the brain and goes through the patient’s streamed lodge in the brain then there is the high chances of ischemic stroke occur. Homographic stroke is second type of stoke which occurs when there is leak of blood or ruptures in the artery in brain. In early stage if the treatment get started we can treat to the ischemic stroke efficiently. If a stroke is feared, or bystanders should call emergency medical services right away. Symptoms disappear as their own in a Ischemic stroke reminded by Transient Ischemic Attack (TIA). As per the research of World Health Organization the 2 nd leading cause of the death worldwide is Brain Stroke which is also responsible for the approximately 11% deaths. but can prevent up to 80% of stokes if they can be identified or predicted early stage stroke. Our ML model uses dataset to predict whether the person has any chances of getting stroke the parameters that are considered to predict stroke are gender, age, disease, smoking status, Cystatin-c , MMP10, Tau Our dataset focuses on major factors which has causes of brain stroke.

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Wu, Simiao, Ruozhen Yuan, Yanan Wang, Chenchen Wei, Shihong Zhang, Xiaoyan Yang, Bo Wu i Ming Liu. "Early Prediction of Malignant Brain Edema After Ischemic Stroke". Stroke 49, nr 12 (grudzień 2018): 2918–27. http://dx.doi.org/10.1161/strokeaha.118.022001.

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Background and Purpose— Malignant brain edema after ischemic stroke has high mortality but limited treatment. Therefore, early prediction is important, and we systematically reviewed predictors and predictive models to identify reliable markers for the development of malignant edema. Methods— We searched Medline and Embase from inception to March 2018 and included studies assessing predictors or predictive models for malignant brain edema after ischemic stroke. Study quality was assessed by a 17-item tool. Odds ratios, mean differences, or standardized mean differences were pooled in random-effects modeling. Predictive models were descriptively analyzed. Results— We included 38 studies (3278 patients) with 24 clinical factors, 7 domains of imaging markers, 13 serum biomarkers, and 4 models. Generally, the included studies were small and showed potential publication bias. Malignant edema was associated with younger age (n=2075; mean difference, −4.42; 95% CI, −6.63 to −2.22), higher admission National Institutes of Health Stroke Scale scores (n=807, median 17–20 versus 5.5–15), and parenchymal hypoattenuation >50% of the middle cerebral artery territory on initial computed tomography (n=420; odds ratio, 5.33; 95% CI, 2.93–9.68). Revascularization (n=1600, odds ratio, 0.37; 95% CI, 0.24–0.57) were associated with a lower risk for malignant edema. Four predictive models all showed an overall C statistic >0.70, with a risk of overfitting. Conclusions— Younger age, higher National Institutes of Health Stroke Scale, and larger parenchymal hypoattenuation on computed tomography are reliable early predictors for malignant edema. Revascularization reduces the risk of malignant edema. Future studies with robust design are needed to explore optimal cutoff age and National Institutes of Health Stroke Scale scores and to validate and improve existing models.

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Jusseaume, Kameron, i Iren Valova. "Brain Age Prediction/Classification through Recurrent Deep Learning with Electroencephalogram Recordings of Seizure Subjects". Sensors 22, nr 21 (23.10.2022): 8112. http://dx.doi.org/10.3390/s22218112.

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With modern population growth and an increase in the average lifespan, more patients are becoming afflicted with neurodegenerative diseases such as dementia and Alzheimer’s. Patients with a history of epilepsy, drug abuse, and mental health disorders such as depression have a larger risk of developing Alzheimer’s and other neurodegenerative diseases later in life. Utilizing recordings of patients’ brain waves obtained from the Temple University abnormal electroencephalogram (EEG) corpus, deep leaning long short-term memory neural networks are utilized to classify and predict patients’ brain ages. The proposed deep learning neural network model structure and brain wave-processing methodology leads to an accuracy of 90% in patients’ brain age classification across six age groups, with a mean absolute error value of 7 years for the brain age regression analysis. The achieved results demonstrate that the use of raw patient-sourced brain wave information leads to higher performance metrics than methods utilizing other brain wave-preprocessing methods and outperforms other deep learning models such as convolutional neural networks.

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Mao, Lingchao, Jing Li, Todd J. Schwedt, Visar Berisha, Devin Nikjou, Teresa Wu, Gina M. Dumkrieger, Katherine B. Ross i Catherine D. Chong. "Questionnaire and structural imaging data accurately predict headache improvement in patients with acute post-traumatic headache attributed to mild traumatic brain injury". Cephalalgia 43, nr 5 (maj 2023): 033310242311727. http://dx.doi.org/10.1177/03331024231172736.

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Background Our prior work demonstrated that questionnaires assessing psychosocial symptoms have utility for predicting improvement in patients with acute post-traumatic headache following mild traumatic brain injury. In this cohort study, we aimed to determine whether prediction accuracy can be refined by adding structural magnetic resonance imaging (MRI) brain measures to the model. Methods Adults with acute post-traumatic headache (enrolled 0–59 days post-mild traumatic brain injury) underwent T1-weighted brain MRI and completed three questionnaires (Sports Concussion Assessment Tool, Pain Catastrophizing Scale, and the Trait Anxiety Inventory Scale). Individuals with post-traumatic headache completed an electronic headache diary allowing for determination of headache improvement at three- and at six-month follow-up. Questionnaire and MRI measures were used to train prediction models of headache improvement and headache trajectory. Results Forty-three patients with post-traumatic headache (mean age = 43.0, SD = 12.4; 27 females/16 males) and 61 healthy controls were enrolled (mean age = 39.1, SD = 12.8; 39 females/22 males). The best model achieved cross-validation Area Under the Curve of 0.801 and 0.805 for predicting headache improvement at three and at six months. The top contributing MRI features for the prediction included curvature and thickness of superior, middle, and inferior temporal, fusiform, inferior parietal, and lateral occipital regions. Patients with post-traumatic headache who did not improve by three months had less thickness and higher curvature measures and notably greater baseline differences in brain structure vs. healthy controls (thickness: p < 0.001, curvature: p = 0.012) than those who had headache improvement. Conclusions A model including clinical questionnaire data and measures of brain structure accurately predicted headache improvement in patients with post-traumatic headache and achieved improvement compared to a model developed using questionnaire data alone.

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Baecker, Lea, Rafael Garcia-Dias, Sandra Vieira, Cristina Scarpazza i Andrea Mechelli. "Machine learning for brain age prediction: Introduction to methods and clinical applications". eBioMedicine 72 (październik 2021): 103600. http://dx.doi.org/10.1016/j.ebiom.2021.103600.

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Han, Hongfang, Sheng Ge i Haixian Wang. "Prediction of brain age based on the community structure of functional networks". Biomedical Signal Processing and Control 79 (styczeń 2023): 104151. http://dx.doi.org/10.1016/j.bspc.2022.104151.

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Ly, Maria, Gary Z. Yu, Helmet T. Karim, Nishita R. Muppidi, Akiko Mizuno, William E. Klunk i Howard J. Aizenstein. "Improving brain age prediction models: incorporation of amyloid status in Alzheimer's disease". Neurobiology of Aging 87 (marzec 2020): 44–48. http://dx.doi.org/10.1016/j.neurobiolaging.2019.11.005.

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Monti, Ricardo Pio, Alex Gibberd, Sandipan Roy, Matthew Nunes, Romy Lorenz, Robert Leech, Takeshi Ogawa, Motoaki Kawanabe i Aapo Hyvärinen. "Interpretable brain age prediction using linear latent variable models of functional connectivity". PLOS ONE 15, nr 6 (10.06.2020): e0232296. http://dx.doi.org/10.1371/journal.pone.0232296.

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Richard, Geneviève, Knut Kolskår, Anne-Marthe Sanders, Tobias Kaufmann, Anders Petersen, Nhat Trung Doan, Jennifer Monereo Sánchez i in. "Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry". PeerJ 6 (30.11.2018): e5908. http://dx.doi.org/10.7717/peerj.5908.

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Multimodal imaging enables sensitive measures of the architecture and integrity of the human brain, but the high-dimensional nature of advanced brain imaging features poses inherent challenges for the analyses and interpretations. Multivariate age prediction reduces the dimensionality to one biologically informative summary measure with potential for assessing deviations from normal lifespan trajectories. A number of studies documented remarkably accurate age prediction, but the differential age trajectories and the cognitive sensitivity of distinct brain tissue classes have yet to be adequately characterized. Exploring differential brain age models driven by tissue-specific classifiers provides a hitherto unexplored opportunity to disentangle independent sources of heterogeneity in brain biology. We trained machine-learning models to estimate brain age using various combinations of FreeSurfer based morphometry and diffusion tensor imaging based indices of white matter microstructure in 612 healthy controls aged 18–87 years. To compare the tissue-specific brain ages and their cognitive sensitivity, we applied each of the 11 models in an independent and cognitively well-characterized sample (n = 265, 20–88 years). Correlations between true and estimated age and mean absolute error (MAE) in our test sample were highest for the most comprehensive brain morphometry (r = 0.83, CI:0.78–0.86, MAE = 6.76 years) and white matter microstructure (r = 0.79, CI:0.74–0.83, MAE = 7.28 years) models, confirming sensitivity and generalizability. The deviance from the chronological age were sensitive to performance on several cognitive tests for various models, including spatial Stroop and symbol coding, indicating poorer performance in individuals with an over-estimated age. Tissue-specific brain age models provide sensitive measures of brain integrity, with implications for the study of a range of brain disorders.

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Hellstrøm, Torgeir, Nada Andelic, Ann-Marie G. de Lange, Eirik Helseth, Kristin Eiklid i Lars T. Westlye. "Apolipoprotein ɛ4 Status and Brain Structure 12 Months after Mild Traumatic Injury: Brain Age Prediction Using Brain Morphometry and Diffusion Tensor Imaging". Journal of Clinical Medicine 10, nr 3 (22.01.2021): 418. http://dx.doi.org/10.3390/jcm10030418.

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Background: Apolipoprotein E (APOE) ɛ4 is associated with poor outcome following moderate to severe traumatic brain injury (TBI). There is a lack of studies investigating the influence of APOE ɛ4 on intracranial pathology following mild traumatic brain injury (MTBI). This study explores the association between APOE ɛ4 and MRI measures of brain age prediction, brain morphometry, and diffusion tensor imaging (DTI). Methods: Patients aged 16 to 65 with acute MTBI admitted to the trauma center were included. Multimodal MRI was performed 12 months after injury and associated with APOE ɛ4 status. Corrections for multiple comparisons were done using false discovery rate (FDR). Results: Of included patients, 123 patients had available APOE, volumetric, and DTI data of sufficient quality. There were no differences between APOE ɛ4 carriers (39%) and non-carriers in demographic and clinical data. Age prediction revealed high accuracy both for the DTI-based and the brain morphometry based model. Group comparisons revealed no significant differences in brain-age gap between ɛ4 carriers and non-carriers, and no significant differences in conventional measures of brain morphometry and volumes. Compared to non-carriers, APOE ɛ4 carriers showed lower fractional anisotropy (FA) in the hippocampal part of the cingulum bundle, which did not remain significant after FDR adjustment. Conclusion: APOE ɛ4 carriers might be vulnerable to reduced neuronal integrity in the cingulum. Larger cohort studies are warranted to replicate this finding.

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Nygate, Yoav, Sam Rusk, Chris Fernandez, Nick Glattard, Jessica Arguelles, Jiaxiao Shi, Dennis Hwang i Nathaniel Watson. "543 EEG-Based Deep Neural Network Model for Brain Age Prediction and Its Association with Patient Health Conditions". Sleep 44, Supplement_2 (1.05.2021): A214. http://dx.doi.org/10.1093/sleep/zsab072.541.

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Abstract Introduction Electroencephalogram (EEG) provides clinically relevant information for personalized patient health evaluation and comprehensive assessment of sleep. EEG-based indices have been associated with neurodegenerative conditions, psychiatric disorders, and metabolic and cardiovascular disease, and hold promise as a biomarker for brain health. Methods A deep neural network (DNN) model was trained to predict the age of patients using raw EEG signals recorded during clinical polysomnography (PSG). The DNN was trained on N=126,241 PSGs, validated on N=6,638, and tested on a holdout set of N=1,172. The holdout dataset included several categories of patient demographic and diagnostic parameters, allowing us to examine the association between brain age and a variety of medical conditions. Brain age was assessed by subtracting the individual’s chronological brain age from their EEG-predicted brain age (Brain Age Index; BAI), and then taking the absolute value of this variable (Absolute Brain Age Index; ABAI). We then constructed two regression models to test the relationship between BAI/ABAI and the following list of patient parameters: sex, BMI, depression, alcohol/drug problems, memory/concentration problems, epilepsy/seizures, diabetes, stroke, severe excessive daytime sleepiness (e.g., Epworth Sleepiness Scale ≥ 16; EDS), apnea-hypopnea index (AHI), arousal index (ArI), and sleep efficiency (SE). Results The DNN brain age model produced a mean absolute error of 4.604 and a Pearson’s r value of 0.933 which surpass the performance of prior research. In our regression analyses, we found a statistically significant relationship between the ABAI and: epilepsy and seizure disorders, stroke, elevated AHI, elevated ArI, and low SE (all p<0.05). This demonstrates these health conditions are associated with deviations of one’s predicted brain age from their chronological brain age. We also found patients with diabetes, depression, severe EDS, hypertension, and/or memory and concentration problems showed, on average, an elevated BAI compared to the healthy population sample (all p<0.05). Conclusion We show DNNs can accurately predict the brain age of healthy patients based on their raw, PSG derived, EEG recordings. Furthermore, we reveal indices, such as BAI and ABAI, display unique characteristics within different diseased populations, highlighting their potential value as novel diagnostic biomarker and potential “vital sign” of brain health. Support (if any):

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Verscheijden, Laurens F. M., Carlijn H. C. Litjens, Jan B. Koenderink, Ron H. J. Mathijssen, Marcel M. Verbeek, Saskia N. de Wildt i Frans G. M. Russel. "Physiologically based pharmacokinetic/pharmacodynamic model for the prediction of morphine brain disposition and analgesia in adults and children". PLOS Computational Biology 17, nr 3 (4.03.2021): e1008786. http://dx.doi.org/10.1371/journal.pcbi.1008786.

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Morphine is a widely used opioid analgesic, which shows large differences in clinical response in children, even when aiming for equivalent plasma drug concentrations. Age-dependent brain disposition of morphine could contribute to this variability, as developmental increase in blood-brain barrier (BBB) P-glycoprotein (Pgp) expression has been reported. In addition, age-related pharmacodynamics might also explain the variability in effect. To assess the influence of these processes on morphine effectiveness, a multi-compartment brain physiologically based pharmacokinetic/pharmacodynamic (PB-PK/PD) model was developed in R (Version 3.6.2). Active Pgp-mediated morphine transport was measured in MDCKII-Pgp cells grown on transwell filters and translated by an in vitro-in vivo extrapolation approach, which included developmental Pgp expression. Passive BBB permeability of morphine and its active metabolite morphine-6-glucuronide (M6G) and their pharmacodynamic parameters were derived from experiments reported in literature. Model simulations after single dose morphine were compared with measured and published concentrations of morphine and M6G in plasma, brain extracellular fluid (ECF) and cerebrospinal fluid (CSF), as well as published drug responses in children (1 day– 16 years) and adults. Visual predictive checks indicated acceptable overlays between simulated and measured morphine and M6G concentration-time profiles and prediction errors were between 1 and -1. Incorporation of active Pgp-mediated BBB transport into the PB-PK/PD model resulted in a 1.3-fold reduced brain exposure in adults, indicating only a modest contribution on brain disposition. Analgesic effect-time profiles could be described reasonably well for older children and adults, but were largely underpredicted for neonates. In summary, an age-appropriate morphine PB-PK/PD model was developed for the prediction of brain pharmacokinetics and analgesic effects. In the neonatal population, pharmacodynamic characteristics, but not brain drug disposition, appear to be altered compared to adults and older children, which may explain the reported differences in analgesic effect.

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Sun, H., K. Dunham, L. Cunningham, Y. Ni, M. Westover i R. Thomas. "0348 Sleep EEG-Based Brain Age Index is Reduced Under Continuous Positive Airway Pressure Treatment". Sleep 43, Supplement_1 (kwiecień 2020): A132. http://dx.doi.org/10.1093/sleep/zsaa056.345.

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Abstract Introduction Continuous positive airway pressure (CPAP) is a treatment for apnea. With long-term CPAP, changes in electroencephalogram (EEG) include increased delta power (1 - 4Hz) and sigma power (11 - 15Hz, spindle). However, the short-term EEG response to CPAP in a split-night study is less quantified. We recently developed a “brain age” model using sleep EEG features. The brain age index (BAI) is defined as the difference between chronological age and brain age (BA - CA). Here we first quantify how BAI changes during CPAP in the same patient, and then investigate how much brain age features during the diagnostic part can predict the reduction in apnea-hypopnea index (AHI) during CPAP. Methods The dataset consisted of 160 subjects. The average age was 59 years with 53% male, 24% female and 23% unknown. We extracted 480 features including band powers, and then computed the BAIs for both diagnostic and CPAP parts. To predict the reduction in AHI during CPAP, we fit a Bayesian regression model using the brain age features, demographics, and sleep parameters during the diagnostic part, and assessed the feature importance using dominance analysis. Results The BAI from the diagnostic part is significantly reduced compared to BAI during CPAP for the same subject (paired t-test, p < 0.01). The diagnostic part has an average BAI 2.24 years; and the CPAP part -4.75 years. The brain age features that are increased during CPAP include sigma powers in N2 and N3. The prediction of AHI reduction has Pearson’s correlation 0.85. The features predictive of reduced AHI are the diagnostic AHI (explained variance 69%), followed by high/low waveforms during N2 (e.g. K-complex, measured by kurtosis) (8.6%), delta power during REM (4.5%) and N1 (2%). The feature predictive of increased AHI is frontal alpha power during quiet awake (2.6%). Conclusion The average BAI is reduced during CPAP. BAI provides a novel view of the acute response to CPAP in sleep EEG. Future study with more CPAP failure patients has the potential of predicting CPAP failure. Support MBW is supported by Glenn Foundation for Medical Research. RJT is supported by Category I AASM Foundation.

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Romagnosi, Federico, Adriano Bernini, Filippo Bongiovanni, Carolina Iaquaniello, John-Paul Miroz, Giuseppe Citerio, Fabio Silvio Taccone i Mauro Oddo. "Neurological Pupil Index for the Early Prediction of Outcome in Severe Acute Brain Injury Patients". Brain Sciences 12, nr 5 (6.05.2022): 609. http://dx.doi.org/10.3390/brainsci12050609.

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In this study, we examined the early value of automated quantitative pupillary examination, using the Neurological Pupil index (NPi), to predict the long-term outcome of acute brain injured (ABI) patients. We performed a single-centre retrospective study (October 2016–March 2019) in ABI patients who underwent NPi measurement during the first 3 days following brain insult. We examined the performance of NPi—alone or in combination with other baseline demographic (age) and radiologic (CT midline shift) predictors—to prognosticate unfavourable 6-month outcome (Glasgow Outcome Scale 1–3). A total of 145 severely brain-injured subjects (65 traumatic brain injury, TBI; 80 non-TBI) were studied. At each time point tested, NPi <3 was highly predictive of unfavourable outcome, with highest specificity (100% (90–100)) at day 3 (sensitivity 24% (15–35), negative predictive value 36% (34–39)). The addition of NPi, from day 1 following ABI to age and cerebral CT scan, provided the best prognostic performance (AUROC curve 0.85 vs. 0.78 without NPi, p = 0.008; DeLong test) for 6-month neurological outcome prediction. NPi, assessed at the early post-injury phase, has a superior ability to predict unfavourable long-term neurological outcomes in severely brain-injured patients. The added prognostic value of NPi was most significant when complemented with baseline demographic and radiologic information.

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Simfukwe, Chanda, i Young Chul Youn. "Prediction of East Asian Brain Age using Machine Learning Algorithms Trained With Community-based Healthy Brain MRI". Dementia and Neurocognitive Disorders 21, nr 4 (2022): 138. http://dx.doi.org/10.12779/dnd.2022.21.4.138.

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Holm, Madelene C., Esten H. Leonardsen, Dani Beck, Andreas Dahl, Rikka Kjelkenes, Ann-Marie G. de Lange i Lars T. Westlye. "Linking brain maturation and puberty during early adolescence using longitudinal brain age prediction in the ABCD cohort". Developmental Cognitive Neuroscience 60 (kwiecień 2023): 101220. http://dx.doi.org/10.1016/j.dcn.2023.101220.

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Ballester, Pedro L., Laura Tomaz da Silva, Matheus Marcon, Nathalia Bianchini Esper, Benicio N. Frey, Augusto Buchweitz i Felipe Meneguzzi. "Predicting Brain Age at Slice Level: Convolutional Neural Networks and Consequences for Interpretability". Frontiers in Psychiatry 12 (25.02.2021). http://dx.doi.org/10.3389/fpsyt.2021.598518.

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Problem: Chronological aging in later life is associated with brain degeneration processes and increased risk for disease such as stroke and dementia. With a worldwide tendency of aging populations and increased longevity, mental health, and psychiatric research have paid increasing attention to understanding brain-related changes of aging. Recent findings suggest there is a brain age gap (a difference between chronological age and brain age predicted by brain imaging indices); the magnitude of the gap may indicate early onset of brain aging processes and disease. Artificial intelligence has allowed for a narrowing of the gap in chronological and predicted brain age. However, the factors that drive model predictions of brain age are still unknown, and there is not much about these factors that can be gleaned from the black-box nature of machine learning models. The goal of the present study was to test a brain age regression approach that is more amenable to interpretation by researchers and clinicians.Methods: Using convolutional neural networks we trained multiple regressor models to predict brain age based on single slices of magnetic resonance imaging, which included gray matter- or white matter-segmented inputs. We evaluated the trained models in all brain image slices to generate a final prediction of brain age. Unlike whole-brain approaches to classification, the slice-level predictions allows for the identification of which brain slices and associated regions have the largest difference between chronological and neuroimaging-derived brain age. We also evaluated how model predictions were influenced by slice index and plane, participant age and sex, and MRI data collection site.Results: The results show, first, that the specific slice used for prediction affects prediction error (i.e., difference between chronological age and neuroimaging-derived brain age); second, the MRI site-stratified separation of training and test sets removed site effects and also minimized sex effects; third, the choice of MRI slice plane influences the overall error of the model.Conclusion: Compared to whole brain-based predictive models of neuroimaging-derived brain age, slice-based approach improves the interpretability and therefore the reliability of the prediction of brain age using MRI data.

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Kuo, Chen-Yuan, Tsung-Ming Tai, Pei-Lin Lee, Chiu-Wang Tseng, Chieh-Yu Chen, Liang-Kung Chen, Cheng-Kuang Lee, Kun-Hsien Chou, Simon See i Ching-Po Lin. "Improving Individual Brain Age Prediction Using an Ensemble Deep Learning Framework". Frontiers in Psychiatry 12 (23.03.2021). http://dx.doi.org/10.3389/fpsyt.2021.626677.

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Brain age is an imaging-based biomarker with excellent feasibility for characterizing individual brain health and may serve as a single quantitative index for clinical and domain-specific usage. Brain age has been successfully estimated using extensive neuroimaging data from healthy participants with various feature extraction and conventional machine learning (ML) approaches. Recently, several end-to-end deep learning (DL) analytical frameworks have been proposed as alternative approaches to predict individual brain age with higher accuracy. However, the optimal approach to select and assemble appropriate input feature sets for DL analytical frameworks remains to be determined. In the Predictive Analytics Competition 2019, we proposed a hierarchical analytical framework which first used ML algorithms to investigate the potential contribution of different input features for predicting individual brain age. The obtained information then served as a priori knowledge for determining the input feature sets of the final ensemble DL prediction model. Systematic evaluation revealed that ML approaches with multiple concurrent input features, including tissue volume and density, achieved higher prediction accuracy when compared with approaches with a single input feature set [Ridge regression: mean absolute error (MAE) = 4.51 years, R2 = 0.88; support vector regression, MAE = 4.42 years, R2 = 0.88]. Based on this evaluation, a final ensemble DL brain age prediction model integrating multiple feature sets was constructed with reasonable computation capacity and achieved higher prediction accuracy when compared with ML approaches in the training dataset (MAE = 3.77 years; R2 = 0.90). Furthermore, the proposed ensemble DL brain age prediction model also demonstrated sufficient generalizability in the testing dataset (MAE = 3.33 years). In summary, this study provides initial evidence of how-to efficiency for integrating ML and advanced DL approaches into a unified analytical framework for predicting individual brain age with higher accuracy. With the increase in large open multiple-modality neuroimaging datasets, ensemble DL strategies with appropriate input feature sets serve as a candidate approach for predicting individual brain age in the future.

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Gong, Weikang, Christian F. Beckmann, Andrea Vedaldi, Stephen M. Smith i Han Peng. "Optimising a Simple Fully Convolutional Network for Accurate Brain Age Prediction in the PAC 2019 Challenge". Frontiers in Psychiatry 12 (10.05.2021). http://dx.doi.org/10.3389/fpsyt.2021.627996.

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Brain age prediction from brain MRI scans not only helps improve brain ageing modelling generally, but also provides benchmarks for predictive analysis methods. Brain-age delta, which is the difference between a subject's predicted age and true age, has become a meaningful biomarker for the health of the brain. Here, we report the details of our brain age prediction models and results in the Predictive Analysis Challenge 2019. The aim of the challenge was to use T1-weighted brain MRIs to predict a subject's age in multicentre datasets. We apply a lightweight deep convolutional neural network architecture, Simple Fully Convolutional Neural Network (SFCN), and combined several techniques including data augmentation, transfer learning, model ensemble, and bias correction for brain age prediction. The model achieved first place in both of the two objectives in the PAC 2019 brain age prediction challenge: Mean absolute error (MAE) = 2.90 years without bias removal (Second Place = 3.09 yrs; Third Place = 3.33 yrs), and MAE = 2.95 years with bias removal, leading by a large margin (Second Place = 3.80 yrs; Third Place = 3.92 yrs).

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Niu, Xin, Alexei Taylor, Russell T. Shinohara, John Kounios i Fengqing Zhang. "Multidimensional Brain-Age Prediction Reveals Altered Brain Developmental Trajectory in Psychiatric Disorders". Cerebral Cortex, 30.01.2022. http://dx.doi.org/10.1093/cercor/bhab530.

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Abstract Brain-age prediction has emerged as a novel approach for studying brain development. However, brain regions change in different ways and at different rates. Unitary brain-age indices represent developmental status averaged across the whole brain and therefore do not capture the divergent developmental trajectories of various brain structures. This staggered developmental unfolding, determined by genetics and postnatal experience, is implicated in the progression of psychiatric and neurological disorders. We propose a multidimensional brain-age index (MBAI) that provides regional age predictions. Using a database of 556 individuals, we identified clusters of imaging features with distinct developmental trajectories and built machine learning models to obtain brain-age predictions from each of the clusters. Our results show that the MBAI provides a flexible analysis of region-specific brain-age changes that are invisible to unidimensional brain-age. Importantly, brain-ages computed from region-specific feature clusters contain complementary information and demonstrate differential ability to distinguish disorder groups (e.g., depression and oppositional defiant disorder) from healthy controls. In summary, we show that MBAI is sensitive to alterations in brain structures and captures distinct regional change patterns that may serve as biomarkers that contribute to our understanding of healthy and pathological brain development and the characterization and diagnosis of psychiatric disorders.

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Hong, Jinwoo, Hyuk Jin Yun, Gilsoon Park, Seonggyu Kim, Yangming Ou, Lana Vasung, Caitlin K. Rollins i in. "Optimal Method for Fetal Brain Age Prediction Using Multiplanar Slices From Structural Magnetic Resonance Imaging". Frontiers in Neuroscience 15 (11.10.2021). http://dx.doi.org/10.3389/fnins.2021.714252.

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The accurate prediction of fetal brain age using magnetic resonance imaging (MRI) may contribute to the identification of brain abnormalities and the risk of adverse developmental outcomes. This study aimed to propose a method for predicting fetal brain age using MRIs from 220 healthy fetuses between 15.9 and 38.7 weeks of gestational age (GA). We built a 2D single-channel convolutional neural network (CNN) with multiplanar MRI slices in different orthogonal planes without correction for interslice motion. In each fetus, multiple age predictions from different slices were generated, and the brain age was obtained using the mode that determined the most frequent value among the multiple predictions from the 2D single-channel CNN. We obtained a mean absolute error (MAE) of 0.125 weeks (0.875 days) between the GA and brain age across the fetuses. The use of multiplanar slices achieved significantly lower prediction error and its variance than the use of a single slice and a single MRI stack. Our 2D single-channel CNN with multiplanar slices yielded a significantly lower stack-wise MAE (0.304 weeks) than the 2D multi-channel (MAE = 0.979, p < 0.001) and 3D (MAE = 1.114, p < 0.001) CNNs. The saliency maps from our method indicated that the anatomical information describing the cortex and ventricles was the primary contributor to brain age prediction. With the application of the proposed method to external MRIs from 21 healthy fetuses, we obtained an MAE of 0.508 weeks. Based on the external MRIs, we found that the stack-wise MAE of the 2D single-channel CNN (0.743 weeks) was significantly lower than those of the 2D multi-channel (1.466 weeks, p < 0.001) and 3D (1.241 weeks, p < 0.001) CNNs. These results demonstrate that our method with multiplanar slices accurately predicts fetal brain age without the need for increased dimensionality or complex MRI preprocessing steps.

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Hsu, Yi-Fang, Florian Waszak, Juho Strömmer i Jarmo A. Hämäläinen. "Human Brain Ages With Hierarchy-Selective Attenuation of Prediction Errors". Cerebral Cortex, 1.12.2020. http://dx.doi.org/10.1093/cercor/bhaa352.

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Abstract From the perspective of predictive coding, our brain embodies a hierarchical generative model to realize perception, which proactively predicts the statistical structure of sensory inputs. How are these predictive processes modified as we age? Recent research suggested that aging leads to decreased weighting of sensory inputs and increased reliance on predictions. Here we investigated whether this age-related shift from sensorium to predictions occurs at all levels of hierarchical message passing. We recorded the electroencephalography responses with an auditory local–global paradigm in a cohort of 108 healthy participants from 3 groups: seniors, adults, and adolescents. The detection of local deviancy seems largely preserved in older individuals at earlier latency (including the mismatch negativity followed by the P3a but not the reorienting negativity). In contrast, the detection of global deviancy is clearly compromised in older individuals, as they showed worse task performance and attenuated P3b. Our findings demonstrate that older brains show little decline in sensory (i.e., first-order) prediction errors but significant diminution in contextual (i.e., second-order) prediction errors. Age-related deficient maintenance of auditory information in working memory might affect whether and how lower-level prediction errors propagate to the higher level.

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Ganaie, M. A., M. Tanveer i Iman Beheshti. "Brain age prediction using improved twin SVR". Neural Computing and Applications, 7.01.2022. http://dx.doi.org/10.1007/s00521-021-06518-1.

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Fang, Keke, Shaoqiang Han, Yuming Li, Jing Ding, Jilian Wu i Wenzhou Zhang. "The Vital Role of Central Executive Network in Brain Age: Evidence From Machine Learning and Transcriptional Signatures". Frontiers in Neuroscience 15 (7.09.2021). http://dx.doi.org/10.3389/fnins.2021.733316.

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Recent studies combining neuroimaging with machine learning methods successfully infer an individual’s brain age, and its discrepancy with the chronological age is used to identify age-related diseases. However, which brain networks play decisive roles in brain age prediction and the underlying biological basis of brain age remain unknown. To answer these questions, we estimated an individual’s brain age in the Southwest University Adult Lifespan Dataset (N = 492) from the gray matter volumes (GMV) derived from T1-weighted MRI scans by means of Gaussian process regression. Computational lesion analysis was performed to determine the importance of each brain network in brain age prediction. Then, we identified brain age-related genes by using prior brain-wide gene expression data, followed by gene enrichment analysis using Metascape. As a result, the prediction model successfully inferred an individual’s brain age and the computational lesion prediction results identified the central executive network as a vital network in brain age prediction (Steiger’s Z = 2.114, p = 0.035). In addition, the brain age-related genes were enriched in Gene Ontology (GO) processes/Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways grouped into numbers of clusters, such as regulation of iron transmembrane transport, synaptic signaling, synapse organization, retrograde endocannabinoid signaling (e.g., dopaminergic synapse), behavior (e.g., memory and associative learning), neurotransmitter secretion, and dendrite development. In all, these results reveal that the GMV of the central executive network played a vital role in predicting brain age and bridged the gap between transcriptome and neuroimaging promoting an integrative understanding of the pathophysiology of brain age.

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Anatürk, Melis, Tobias Kaufmann, James H. Cole, Sana Suri, Ludovica Griffanti, Enikő Zsoldos, Nicola Filippini i in. "Prediction of brain age and cognitive age: Quantifying brain and cognitive maintenance in aging". Human Brain Mapping, 14.12.2020. http://dx.doi.org/10.1002/hbm.25316.

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Ballester, Pedro L., Jee Su Suh, Natalie C. W. Ho, Liangbing Liang, Stefanie Hassel, Stephen C. Strother, Stephen R. Arnott i in. "Gray matter volume drives the brain age gap in schizophrenia: a SHAP study". Schizophrenia 9, nr 1 (9.01.2023). http://dx.doi.org/10.1038/s41537-022-00330-z.

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AbstractNeuroimaging-based brain age is a biomarker that is generated by machine learning (ML) predictions. The brain age gap (BAG) is typically defined as the difference between the predicted brain age and chronological age. Studies have consistently reported a positive BAG in individuals with schizophrenia (SCZ). However, there is little understanding of which specific factors drive the ML-based brain age predictions, leading to limited biological interpretations of the BAG. We gathered data from three publicly available databases - COBRE, MCIC, and UCLA - and an additional dataset (TOPSY) of early-stage schizophrenia (82.5% untreated first-episode sample) and calculated brain age with pre-trained gradient-boosted trees. Then, we applied SHapley Additive Explanations (SHAP) to identify which brain features influence brain age predictions. We investigated the interaction between the SHAP score for each feature and group as a function of the BAG. These analyses identified total gray matter volume (group × SHAP interaction term β = 1.71 [0.53; 3.23]; pcorr < 0.03) as the feature that influences the BAG observed in SCZ among the brain features that are most predictive of brain age. Other brain features also presented differences in SHAP values between SCZ and HC, but they were not significantly associated with the BAG. We compared the findings with a non-psychotic depression dataset (CAN-BIND), where the interaction was not significant. This study has important implications for the understanding of brain age prediction models and the BAG in SCZ and, potentially, in other psychiatric disorders.

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