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Yadav, Priti. "Modelling loading and growth of long bones Modelling loading and growth of long bones". Licentiate thesis, KTH, Biomekanik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-177913.
Pełny tekst źródłaQC 20151201
Chim, Shek Man. "Identification and characterization of novel secreted factors involved in bone remodeling". University of Western Australia. School of Surgery, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0110.
Pełny tekst źródłaMa, Li, i 马丽. "The influence of nicotine on angiogenesis and osteogenesis in bone regeneration". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41508440.
Pełny tekst źródłaOest, Megan Elizabeth. "Dual Osteogenic and Angiogenic Growth Factor Delivery as a Treatment for Segmental Bone Defects". Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/16264.
Pełny tekst źródła關健明 i Kin-ming Kwan. "Defining the function of type X collagen in skeletal development". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31237162.
Pełny tekst źródłaFoster, Bruce Kristian. "Epiphyseal plate repair using fat interposition to reverse physeal deformity : an experimental study". Title page, contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09MD/09mdf754.pdf.
Pełny tekst źródłaChayanupatkul, Atinooch. "Bone formation in the temporomandibular joint in response to forward mandibular positioning". Thesis, Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25598776.
Pełny tekst źródłaCha, Ming Chuan 1955. "The effect of zinc deficiency on the growth promoting actions of growth hormone and insulin-like growth factor-I /". Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55484.
Pełny tekst źródłaDai, Zhijie, i 戴志洁. "The role of sodium/myo-inositol cotransporter 1 and myo-inositol in osteogenesis and bone formation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43783533.
Pełny tekst źródłaDahlgren, Emma. "Effects of Different Load Magnitudes on Longitudinal Growth of Immature Bones". Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-230885.
Pełny tekst źródłaWong, Hoi-leong Xavier, i 王凱亮. "The functional crosstalk between MT1-MMP and ADAMs in craniofacial & vascular development". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197072.
Pełny tekst źródłaSaxon, Leanne, i mikewood@deakin edu au. "The role of exercise in the development of bone strength during growth". Deakin University. School of Health Sciences, 2002. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051125.095337.
Pełny tekst źródłaWong, Wing-Kit Ricky, i 黃永傑. "Bone induction using Simvastatin and Gusuibu". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31246126.
Pełny tekst źródłaBrooker, Molly J. "The effect of acute exercise on bone metabolism in the pre-pubertal child". Virtual Press, 2000. http://liblink.bsu.edu/uhtbin/catkey/1164852.
Pełny tekst źródłaSchool of Physical Education
Liu, Jin. "Increased CKIP-1 suppresses Smad-dependent BMP signaling to inhibit bone formation during aging". HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/327.
Pełny tekst źródłaZheng, Liwu, i 鄭立武. "Biochemical modulation of mandibular distraction osteogenesis". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31246308.
Pełny tekst źródłaAlfonso, Durruty Marta Pilar. "Biosignificance of Harris lines as stress markers in relation to moderate undernutrition and bone growth velocity a New Zealand white rabbit model for the study of bone growth /". Diss., Online access via UMI:, 2008.
Znajdź pełny tekst źródłaGan, Huiyan, i 甘慧妍. "Understanding the role of KIF5B in long bone development and chondrocyte cytokinesis". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/211554.
Pełny tekst źródłapublished_or_final_version
Biochemistry
Doctoral
Doctor of Philosophy
Gluck, Beth. "The Effects of Physical Activity on Bone Density in Adolescent Females". Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/GluckB2004.pdf.
Pełny tekst źródłaBlostein, Ashley C. "Effects of running on hormonal growth factors". Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/865946.
Pełny tekst źródłaSchool of Physical Education
Zhong, Ming. "Apoptotic signaling pathways in mammalian growth plate chondrocytes". Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/33993.
Pełny tekst źródłaKar, Archana. "Hydroxyapatite deposition onto nanoporous TiO2 and assessment of bone cell growth and proliferation". abstract and full text PDF (free order & download UNR users only), 2007. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1447622.
Pełny tekst źródłaMohamad, Yusof Loqman. "Longitudinal growth of mammalian bones : a possible role for membrane transporters in mediating chondrocyte hypertrophy". Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/6481.
Pełny tekst źródłaMoore, Alison Jane. "Quantitative histomorphometric analysis of the bone growth plate in infancy : a comparative study between SIDS and normal subjects /". Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09MSM/09msmm821.pdf.
Pełny tekst źródłaSerrat, Maria A. "Environmentally-determined tissue temperature modulates extremity growth in mammals a potential comprehensive explanation of Allen's Rule /". [Kent, Ohio] : Kent State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1185486409.
Pełny tekst źródłaTitle from PDF t.p. (viewed Mar. 5, 2009). Advisor: C. Owen Lovejoy. Keywords: temperature, bone growth, Allen's Rule, skeletal morphology, limb proportions, environmental effects on bone growth. Includes bibliographical references (p. 157-176).
Zhu, Guixia, i 朱貴霞. "Study of the function of Kinesin-1 (KIF5B) in long bone development". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B41757919.
Pełny tekst źródłaZierath, Juleen R. "Bone mineral content in laboratory rats following swim and run training". Virtual Press, 1986. http://liblink.bsu.edu/uhtbin/catkey/472942.
Pełny tekst źródłaLi, Gang Gang. "Biological studies of distraction osteogenesis". Thesis, University of Oxford, 1997. http://ora.ox.ac.uk/objects/uuid:d2976713-d0f6-439a-a70c-9183d44cff81.
Pełny tekst źródłaTsai, Ming-ju Marjorie. "Replicating mesenchymal cells in the condyle in response to normal growth and mandibular protrusion". Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25575995.
Pełny tekst źródłaValverde, Franco Gladys 1972. "The role of fibroblast growth factor receptor 3 in post-natal cartilage and bone metabolism /". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115917.
Pełny tekst źródłaLangeveldt, Carmen Ronel. "Alternative insulin mitogenic signaling pathways in immature osteoblast cell lines". Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52646.
Pełny tekst źródłaENGLISH ABSTRACT: Insulin is a mitogen for many cells and commonly signals through the classical, mitogenic Raf- MEK-ERK or metabolic PB-kinase pathways. Insulin deficiency or type I diabetes causes severe osteopenia. Obese patients with type II diabetes or insulin resistance, a disease associated with defective insulin signaling pathways and high levels of circulating insulin, have increased or normal bone mineral density. The question of whether hyperinsul inemia preserves bone mass is frequently raised. However, there is still a lot of controversy on the role of insulin as an osteoanabolic agent and this question still remains unanswered. A critical role for insulin signaling in bone building osteoblasts has recently been demonstrated with IRS-l knock-out mice. These mice developed low-turnover osteopenia due to impaired proliferation and differentiation, stressing the importance of osteoblastic IRS-l for maintaining normal bone formation. In the present study it was found that insulin does function in vitro as an osteoblast mitogen. This was illustrated in three relatively immature osteoblast (MBA-15.4, -15.6 mouse and MG- 63 human) cell lines, which responded to insulin with significant increases in proliferation. In the MBA -15.4 preosteoblasts insulin stimulation of proliferation was comparable to the welldescribed mitogen, TPA. The UMR-I06 cell line expresses markers of differentiated osteoblasts, and was much less responsive to insulin treatment. The difference in proliferative potential may be due to differences between spontaneously transformed cell lines, or the stage of cell differentiation. UOI26, a MEKI/2 inhibitor and wortmannin, a PB-kinase inhibitor, were used to investigate the pathway used by insulin to signal and activate ERK and osteoblast proliferation. In MBA-15.4 mouse preosteoblasts, GF-containing FCS was completely dependent on MEK for DNA synthesis. In contrast, in both MBA-15.4 and more mature MBA-15.6 osteoblasts, insulininduced proliferation was resistant to the inhibitors alone or in combination. Higher MEKinhibitor concentrations had no effect, and proliferation was also increased by the inhibitors in several experiments. This indicated that the classical, insulin mitogenic pathway was not involved in MBA-15.4 proliferation. Wortmannin had no effect on either insulin- or 20% FCSstimulated proliferation, but inhibited activation of Akt/PKB, the metabolic downstream target of PI3-kinase. Insul in signal ing to ERK was both MEK-and PI3-kinase- dependent, but this had no effect on proliferation. In contrast, FCS-stimulated ERK activation and proliferation was almost completely dependent on MEK-ERK activation. Proliferative signaling in the MG-63 human osteoblastic cell line in response to insulin was partially dependent on MEK and partially dependent on PB-kinase. In contrast, signaling in response to the phorbol ester, TPA, was partially dependent on PI3K but totally dependent on MEK-ERK. This indicates that the signal converges on ERK, suggesting the involvement of a PB-kinase upstream of a dominant MEK-ERK pathway. The differences found here between mouse and human insulin mitogenic signaling pathways indicate that there may be species differences between osteoblast signaling pathways, with mouse cells being independent and human cells being dependent on MEK for DNA synthesis in response to insulin. The effects of glucocorticoids on insulin mitogenic signaling in osteoblasts were also investigated, because chronic long-term steroid use results in excessive bone loss. The PTP inhibitor, sodium orthovanadate, reversed GC-impaired TPA- and FCS- induced proliferation in MBA-1SA and MG-63 preosteoblasts. PTPs, such as SHP-l and PTP-IB, dephosphorylate and inactivate phosphorylated kinases. Both SHP-l and PTPlB associated with kinases in the mitogenic signaling cascade of MBA-lS.4 preosteoblasts growing rapidly in 10% FCS. Further, SHP-I co-irnmunoprecipitated with active, tyrosine phosphorylated ERK, which may indicate that it can dephosphorylate and inactivate ERK. However, since the MEK-ERK or PB-kinase pathways are not important in insulin-induced proliferation in mouse osteoblasts, the PTPs are unlikely to be role players in the negative regulation of this signaling pathway. This was confirmed by the finding that vanadate was unable to reverse GC-induced decreases in insulinstimulated DNA synthesis. This suggests that vanadate-sensitive PTPs may not be important in the negative regulation of insulin-induced mouse osteoblast proliferation, and provides further evidence of a novel insulin mitogenic pathway in the MBA-lSA but not MG-63 osteoblastic cell line.
AFRIKAANSE OPSOMMING: Insulien is 'n mitogeen vir baie selle en gelei na binding aan die insulien reseptor, intrasellulêre seine via die klassieke, mitogeniese Raf-MEK-ERK of die metaboliese PB-kinase seintransduksie pad. 'n Insulien gebrek of tipe I diabetes veroorsaak osteopenie. Vetsugtige pasiënte met insulien weestandigheid of tipe II diabetes, 'n siekte wat geassosieer word met foutiewe insulien seintransduksie en hoë vlakke van sirkuierende insulien, het verhoogde of normale been mineraal digtheid (BMD). Die vraag of hiper insulin ernie 'n verlies aan beenmassa teëwerk word dikwels gevra. Teenstrydigheid oor die rol van insulien as 'n osteo-anaboliese stof bestaan egter steeds en hierdie vraag bly dus onbeantwoord. Dat insulien seintransduksie wel 'n kritiese rol speel in beenvormende osteoblaste is onlangs bevestig in studies met muise waarvan die geen vir IRS-l uitgeslaan is. Hierdie muise ontwikkel 'n lae omset osteopenie weens verswakte proliferasie en differensiasie. fn hierdie studie is gevind dat insulien wel in vitro as 'n osteoblast mitogeen kan funksioneer. Dit is in drie relatief onvolwasse (MBA-15.4, -15.6 muis en MG-63 mens) sellyne geillistreer, deur betekenisvolle verhogings in insulien-geaktiveerde proliferasie. In MBA-15.4 preosteoblaste is die persentasie verhoging in insulien-gestimuleerde proliferasie vergelykbaar met dié van die bekende mitogeniese forbolester, TPA. Die UMR-I06 sellyn het kenmerke van gedifferensieerde osteoblaste, en was baie minder responsief op insulien behandeling. Die verskil in die proliferasie vermoë van die verskillende sellyne kan die gevolg wees van verskille wat bestaan tussen spontaan getransformeerde sellyne of die stadium van sel differensiasie. 'n MEK 1/2 inhibitor, UO126 en 'n PB-kinase inhibitor, wortmannin, is gebruik om die insulien seintransduksie pad noodsaaklik vir die aktivering van ERK en osteoblast proliferasie te bepaal. In MBA-1S.4 muis pre-osteoblaste, was fetale kalf SenlTI1(FKS)-geinduseerde DNA sintese totaal afhanklik van MEK. Beide die MBA-15.4 en die meer volwasse MBA-15.6 muis osteoblaste was weerstandig teen die inhibitors op hulle eie, of in kombinasie. Verhoogde MEK-inhibitor konsentrasies het geen verdere effek gehad nie en in verskeie eksperimente is 'n verhoging in preliferasie selfs waargeneem met MEK-inhibisie. Hierdie resultate dui aan dat die klassieke insulien mitogeniese pad nie betrokke is in MBA-I5.4 gestimuleerde selproliferasie nie. Wortmannin het geen effek gehad op insulien- of20% FKS-gestimuleerde DNA sintese nie, maar het wel die aktivering van PB-kinase se metaboliese teiken, AktJPKB geinhibeer. Insulien seintransduksie aktiveer dus ERK deur beide MEK en PB-kinase, maar het geen effek op proliferasie gehad nie. FKS-gestimuleerde ERK aktivering en proliferasie was totaal afhanlik van MEK-ERK aktivering. Insulien-geaktiveerde DNA sintese in die mens MG-63 osteoblaste was gedeeltelik afhanklik van beide MEK en PB-kinase. Alhoewel IPA ook PB-kinase kon aktiveer, was dit totaal afhanklik van MEK vir DNA sintese. Dit dui aan dat daar 'n PB-kinase stroom-op van 'n dominante MEK-ERK seintransduksie pad voorkom. Die verskille wat ons dus waargeneem het in insulien mitogeniese seintransduksie tussen muis en mens, kan aandui dat insuliengestimuleerde seintranduksie paaie kan verskil van spesie tot spesie. Dit is bevestig met die muisselle wat onafhanklik is en mens selle wat afhanklik is van MEK aktivering vir insuliengeaktiveerde DNA sintese. Kroniese, langtermyn steroied behandeling kan beenverlies veroorsaak en die effek van glukokortikoide (GK) op die insulien mitogeniese pad in osteoblaste is dus ook ondersoek. Natrium-ortovanadaat, 'n proteien tirosien fosfatase (PIP) inhibitor het GK-verlaagde proliferasie in repons tot beide IPA- en FKS behandeling herstel in MBA-lSA en MG-63 preosteoblaste. PIPs soos SHP-l en PIP-l B funksioneer deur gefosforileerde kinases te defosforileer en dus te inaktiveer. Beide SHP-l and PIP-lB kon assosieer met kinases in die mitogeniese insulien seintransduksie pad van vinnig groeiende MBA-IS A preosteoblaste in 10% FKS. Verder het SHP-I ook geko-immunopresipiteer met aktiewe, tirosien-gefosforileerde ERK, wat aandui dat SHP-I met ERK assosieer om dit te defosforileer en inaktiveer. Die MEKERK of PB-kinase paaie is nie belangrik vir insulien-geaktiveerde seintransduksie in muis osteoblaste nie. Dit is dus onwaarskynlik dat die PIPs 'n rol sal speel in die negatiewe regulering van hierdie seintransduksie paaie. Die ontdekking dat vanadaat nie glukokortikoiedverlaagde insulien-geaktiveerde DNA sintese kan herstel nie, toon dat vanadaat-sensitiewe PIPs nie 'n rol speel in insulien-geaktiveerde proliferasie in muisselle nie. Hierdie bevinding het verder bevestig dat 'n nuwe insulien mitogeniese pad in die MBA-ISA, maar nie die MG-63 selle moontlik bestaan.
Duvall, Craig L. "The Role of osteopontin in postnatal vascular growth functional effects in ischemic limb collateral vessel formation and long bone fracture healing /". Available online, Georgia Institute of Technology, 2006, 2006. http://etd.gatech.edu/theses/available/etd-01102007-130423/.
Pełny tekst źródłaDavid Harrison, Committee Member ; Ravi Bellamkonda, Committee Member ; Larry McIntire, Committee Member ; Oskar Skrinjar, Committee Member ; W. Robert Taylor, Committee Chair ; Robert Guldberg, Committee Chair.
陳卓榮 i Cheuk-wing Wilson Chan. "Molecular basis for increased bone formation in a mouse expressing mutant collagen X". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31227132.
Pełny tekst źródła曹凱韻 i Hoi-wan Tso. "Effects of phagocytosis of apoptotic cells by mesenchymal stem cells on osteogenesis and T cells responses". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39707520.
Pełny tekst źródłaXu, Wei. "The impact of rhizoma chuanxiong in fetal bone development". HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/253.
Pełny tekst źródłaDang, Lei. "Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis". HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/687.
Pełny tekst źródła蔡明汝 i Ming-ju Marjorie Tsai. "Replicating mesenchymal cells in the condyle in response to normal growth and mandibular protrusion". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31973127.
Pełny tekst źródłaEssman, Stephanie Christine. "Effects of ¹⁵³samarium-ethylenediaminetetramethylene phosphonate on physeal and articular cartilage in juvenile rabbits /". Free to MU Campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p1418016.
Pełny tekst źródła黃淑興 i Shu-hing Louise Wong. "Replicating mesenchymal cells in the glenoid fossa in response to mandibular advancement". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31973140.
Pełny tekst źródłaXiong, Hui, i 熊暉. "Condylar adaptation to active mandibular forward positioning in non-growing rats". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31374220.
Pełny tekst źródłaPoon, Chin-ho, i 潘展豪. "Pushing stem cells toward bone lineage through ultrasound stimulation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47849824.
Pełny tekst źródłapublished_or_final_version
Electrical and Electronic Engineering
Master
Master of Philosophy
Monegue, James S. "EVALUATION OF THE EFFECTS OF VITAMIN K ON GROWTH PERFORMANCE AND BONE HEALTH IN SWINE". UKnowledge, 2013. http://uknowledge.uky.edu/animalsci_etds/26.
Pełny tekst źródłaMoreira, Alessandra Arnaud. ""Estudo da utilização clínica das proteínas ósseas morfogenéticas em cirurgia buco-maxilo-facial no Brasil"". Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/23/23143/tde-16032005-161053/.
Pełny tekst źródłaThe use of alloplastic materials for bone replacement has been extensively debated lately by surgeons and researchers in the Oral and Maxillofacial field. In the attempt to reconstruct bone defects anatomically and functionally autogenous bone grafts have been the preferred option. Although being considered the gold standard in craniofacial reconstruction, there are some inconveniences in the use of bone autografts. Among them the need of hospitalization, the need of a donor site usually in a different area than the bone defect, donor area morbidity, longer recovery time, increased risk of infection, and the possibility of bone resorption over time. When the face is operated the use of autogenous bone is even more questionable. Usually small amounts of bone grafts are necessary in the face, and might not justify the morbidity of the donor site. In an attempt to avoid the use of bone autografts, allografts and alloplastic materials have been advertised, in association with bone morphogenetic proteins. These proteins are growth factors involved in the osteogenesis in humans from the fetus up to the adult age. The aim of this study is to evaluate the knowledge and the clinical use of bone morphogenetic proteins in the repair of facial bone defects by Brazilian Oral and Maxillofacial surgeons.
Seo, Hwa-Seon. "The role of TGFß signaling in skeletal development". Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/seo.pdf.
Pełny tekst źródłaBurr, Laura Lynn. "Diet enrichment with arachidonic and docosahexaenoic acid during the lactation period attenuates the effects of intrauterine growth restriction from birth to maturity in the guinea pig and improves maternal bone mass". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112384.
Pełny tekst źródłaDavey, Tamara. "Functional characterisation of a novel osteoclast-derived factor". University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0219.
Pełny tekst źródłaSchwartz, Filho Humberto Osvaldo [UNESP]. "Osteogênese sobre titânio com nanotopografia". Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/110660.
Pełny tekst źródłaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Os objetivos deste estudo foram avaliar a influência da nanotopografia de superfícies de titânio no processo de osteogênese por meio de avaliação histológica do contato osso-implante, em ratos, sob efeito da inalação forçada da fumaça de cigarro; Avaliar a osteogênese e a expressão de citocinas em cultura de células primárias sobre discos de titânio com nanotopografia; E avaliar o efeito morfológico e molecular da incorporação da laminina-1 (LN-1) em superfícies com nanotopografia, em coelhos. Implantes e discos de titânio foram especialmente produzidos e submetidos a diferentes métodos para a obtenção de superfícies: usinada, micro e nanotopografia. As superfícies foram devidamente caracterizadas quanto a sua topografia, morfologia e química. Os resultados mostraram que: a nanotopografia é capaz de aumentar o contato osso-implante (BIC) mesmo na presença da inalação intermitente da fumaça de cigarro, e foi capaz de reduzir, porem não totalmente, seus efeitos deletérios e uma menor formação óssea; A nanotopografia de titânio pode ter papel importante no processo de mineralização da matriz extracelular e na modulação da expressão de citocinas; E que a incorporação de LN-1 a superfície de titânio com nanotopografia demonstrou favorecer uma maior expressão de importantes genes envolvidos na cascata da osseointegração.
The aims of this study were to evaluate the influence of nanotopography of titanium surfaces in the process of osteogenesis by means of histological assessment of bone-implant contact, in rats, under the effect of forced inhalation of cigarette smoke; To assess the osteogenesis process and the expression of cytokines in primary cell culture on titanium disks with nanotopography; And evaluate morphological and molecular the effect of incorporation of laminin-1 (LN-1) surfaces with nanotopography, in rabbits. Implants and titanium disks were specially produced and submitted to different methods for obtaining surfaces with turned, micro and nanotopography. The surfaces have been properly characterized as its topography, morphology and chemistry. The results showed that: nanotopography is able to increase bone-implant contact (BIC) even in the presence of intermittent inhalation of cigarette smoke, and was able to reduce, although not entirely, their harmful effects and a lower bone formation; Nanotopography may play a important role in mineralization process and in cytokine expression.; And the incorporation of LN-1 on titanium surface with nanotopography favor a higher expression of important genes involved in the cascade of osseointegration.
Chan, Cheuk-wing Wilson, i 陳卓榮. "ER stress in the pathogenesis of osteochondrodysplasia". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085192.
Pełny tekst źródłaTurner, Justine Marie. "Adolescent onset anorexia nervosa : a model for the effects of inadequate nutrition upon bone size and development". University of Western Australia. School of Paediatrics and Child Health, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0131.
Pełny tekst źródłaMason, Shelley S. "Exploring Tissue Engineering: Vitamin D3 Influences on the Proliferation and Differentiation of an Engineered Osteoblast Precursor Cell Line During Early Bone Tissue Development". PDXScholar, 2013. https://pdxscholar.library.pdx.edu/open_access_etds/1000.
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