Rozprawy doktorskie na temat „Bone formation/resorption”
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Moroz, Adam. "Reduced order modelling of bone resorption and formation". Thesis, De Montfort University, 2011. http://hdl.handle.net/2086/5409.
Pełny tekst źródłaLean, Jennifer Maree. "Mechanical stimulation of bone formation in the rat". Thesis, St George's, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263682.
Pełny tekst źródłaMiao, Dengshun. "Studies on the actions of bone anabolic drugs in vivo and in vitro". Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300362.
Pełny tekst źródłaAlthnaian, Thnaian Ali. "Factors that regulate osteoclast formation and bone resorption in regenerating deer antlers". Thesis, Royal Veterinary College (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439832.
Pełny tekst źródłaDavey, Tamara. "Functional characterisation of a novel osteoclast-derived factor". University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0219.
Pełny tekst źródłaLoomer, Peter Michael. "The direct effects of Porphyromonas gingivalis 2561 on bone formation and mineral resorption in vitro". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ27685.pdf.
Pełny tekst źródłaOwens, Beatrice H. "Dose-dependent effects of salmon calcitonin on bone turnover in ovariectomized rats". [Johnson City, Tenn. : East Tennessee State University], 2004. http://etd-submit.etsu.edu/etd/theses/available/etd-1120104-223525/unrestricted/OwensB120204f.pdf.
Pełny tekst źródłaTitle from electronic submission form. ETSU ETD database URN: etd-1120104-223525 Includes bibliographical references. Also available via Internet at the UMI web site.
Kassem, Ali. "Toll-like receptors (TLRs) and inflammatory bone modeling". Doctoral thesis, Umeå universitet, Institutionen för odontologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110296.
Pełny tekst źródłaLotz, Ethan M. "Designing Biomimetic Implant Surfaces to Promote Osseointegration under Osteoporotic Conditions by Revitalizing Mechanisms Coupling Bone Resorption to Formation". VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5908.
Pełny tekst źródłaMbimba, Thomas S. Jr. "TRAFICKING PROTEIN PARTICLE COMPLEX (TRAPPC) -9:A NOVEL PROTEIN REGULATOR OF NF-kB MEDIATED BONE FORMATION AND RESORPTION". Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1448841594.
Pełny tekst źródłaTai, Victoria. "The effects of leukotriene B¦4 on osteoclast formation and osteoclastic bone resorption and the role of osteoblastic cells in these processes". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ28805.pdf.
Pełny tekst źródłaAntunes, Antonio Azoubel. "Tratamento de defeitos ósseos cervicais com materiais osseocondutores porosos imediatamente à instalação de implantes: estudo histológico, histométrico, micro-tomográfico e de análise de frequência de ressonância em cães". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/58/58136/tde-03102013-112834/.
Pełny tekst źródłaThe aim of this study was to compare the effectiveness of porous biomaterials in bone formation and repair of cervical mandibular defects in dogs, with or without Guided Bone Regeneration (GBR) technique. Bio-Oss Block® (BB), Bio-Oss Collagen® (BC), Bio-Oss® in granules (BG), autogenous bone (Ab) and coagulum (Cg) were used under the same experimental conditions. For the membrane group, BioGide® was used. Twelve dogs underwent bilateral extractions of mandibular premolars and first molars. After four months five bone defects (6 mm long / 4 mm deep) were prepared at one side. Implants of 3.3 x 10 mm were installed on each of mesial defect, providing a distal gap of 2.7 mm. The defects were randomly filled with Ab, Cg, BB, BC and BG. The same procedures were performed in the opposite side after eight weeks. A membrane was used to cover the defects in half of the sides. Animals were sacrificed after eight weeks. Implant stability was measured by Osstell Mentor®, at implant installation and sacrifice. The specimens (n=60, 3 in each group) were scanned in Skyscan® 1172 micro-CT scanner. A volume of interest of 3.0 x 6.0 x 4.0 mm was established and the parameters related to bone formation were evaluated. All used biomaterials were also scanned for in vitro porosity evaluation. Using Exakt® system, ground section of each specimen were prepared for histological and histometric assessment. Histometric analysis revealed that BC presented similar bone formation to Ab in 8 weeks without BGd. Cg showed greater bone formation between treatments at 16 weeks with BGd, and was superior to BG and BB at 8 weeks without BGd (p<0.05). BB exhibited worse bone formation within treatments (8 and 16 weeks, with or without membrane). BC had the best performance among biomaterials. All biomaterials were partially resorbed from 8 to 16 weeks. However, BB was found in greater amounts in comparison with other biomaterials (p<0.05). Regarding the alveolar crest analysis, BB had the lowest resorption between treatments with and without BGd at 8 and 16 weeks (p<0,05). The BGd use promoted higher final ISQ values at 16 weeks, regardless the tested treatment (p<0.05). Micro-CT analysis showed that when BGd was not used, BG yielded the highest amount of bone within the defect, followed by BC (p<0.05). When the defect was covered with BGd, Ab yielded higher bone formation (p>0.05). Bone surface area analysis showed that increased values in sites treated with BG, followed by BC without BGd at 8 weeks, and Ab at 8 weeks with BGd (p<0.05). The BC presented greater Bone Surface Area/Bone volume at 8 (with and without BGd) and 16 weeks with BGd (p<0.05). BB had the lowest values at 16 weeks (without BGd). Cg presented the worst performance among treatments at 16 weeks (with BGd) (p<0.05). Regarding the Trabecular Thickness, Ab and BB showed the highest and lowest values, respectively (p<0.05), regardless of the time point or membrane use. In biomaterials porosity analysis, BG showed higher numbers, volume, and surface area of closed pores. BB had the highest volume of open pores, open porosity and total porosity compared with the other treatments. It can be concluded the use of a high porosity block (BB) failed to provide greater bone formation within the defect area and it was the treatment that better reduced distal alveolar crest resorption. Biomaterials with lower porosity (BC and BG) showed higher or similar bone formation and implant stability if compared to autogenous bone. The appliance of BGd improved bone formation in all treatments and tested periods and reduced soft tissue presence within the defect. An inverse relationship between biomaterials\' in vitro porosity and in vivo bone formation was observed in the experimental model used.
Terndrup, Haley Frances, Alison K. Ventura, Todd Hagobian i Scott Hazelwood. "THE EFFECTS OF A UNIFORMLY WEIGHTED EXERCISE SUIT ON BIOMARKERS OF BONE TURNOVER IN RESPONSE TO AEROBIC EXERCISE IN POSTMENOPAUSAL WOMEN WITH LOW BONE DENSITY". DigitalCommons@CalPoly, 2016. https://digitalcommons.calpoly.edu/theses/1637.
Pełny tekst źródłaHuang, Mei Yueh, i 黃美月. "Effects of Interleukin-1 on Bone Formation and Bone Resorption". Thesis, 1994. http://ndltd.ncl.edu.tw/handle/07163209475470901384.
Pełny tekst źródła國防醫學院
解剖學研究所
82
The purposes of this study were:1)to establish an in vitro model of bone formation, 2)to investigate the effects of interleukin-1(IL-1 )on bone formation,3)to establish an in vitro bioassay of osteoclast formation and 4)to clarify the effects of IL-1 on bone resorption. Thirteen-fourteen day BALB/C fetal calvarial cells were obtained and cultured for 3 weeks.With light microscopic observation, quantitation of bone colony and alkaline phosphatase assay, an in vitro model of bone formation could be established. By this model, daily adding of IL-1 was performed during culture of fetal calvarial cells.The effect of IL-1 on bone formation was evaluated using the same methods mentioned above.In addition, 14-day fetal calvarial explant was obtained and cultured for 10 days. Light density mononuclear cells were collected and co- cultured with bone explant.Ten day after co-culture, osteoclasts were formed. By this model,IL-1 was added daily during co-culture.Ten days later, the precise effect of IL-1 on bone resorption was evaluated.The results of this study indicated that:1)a new in vitro model of bone formation was established,2)there was a positive correlation between the number of plated cells and the number of bone clolnies,3)IL-1 exerted a potent dose-dependent inhibition on bone formation,4)a suitable in vitro model of osteoclast formation was established, 5)IL-1 could stimulate bone resorption in a dose- related fashion,6)the increase in the number of osteo- clasts was probably caused by stimulating the fusion of mononuclasr cells and 7)IL-1 could act "uncoupling factor" in bone remodeling process.
Huang, Chun-Huang, i 黃駿煌. "Effects of bone resorption, bone formation, and immune tolerance on the development of Taiwanese ankylosing spondylitis". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/59749297306165297493.
Pełny tekst źródła中山醫學大學
醫學研究所
101
Ankylosing spondylitis (AS) is a chronic inflammatiory disorder. Inflammation has been reported to promote the differentiation and maturation of the osteoclast, and bone resorption also affects the overexpression of the osteoblast resulting in the bone formation and syndesmophyte. In addition, imbalance of autoimmune tolerance is associated with the occurrence of autoimmune diseases. The higher expression of CD4+ and CD8+ T cells has also been found in AS patients than in healthy controls, and such expression may relate to the imbalance in the negative signal of activated T cells. Receptor activator of nuclear factor kappa B ligand (RANKL) binds to receptor activator of nuclear factor kappa B (RANK) could cause the activation of bone resorption. Osteoprotegerin (OPG) also competes with RANK by binding to RANKL and inhibiting bone absorptions. Therefore, we designed a case-control study to evaluate the association between occurance and clinical features of AS and RANK, RANKL and OPG genetic polymorphisms. A total of 330 AS patients and 330 age- and gender-matched healthy controls were recruited. Results revealed OPG GG genotype carriers had an elevated risk of AS compared with those with the GC and CC genotypes (odds ratio [OR] 1.74, 95% confidence interval [CI] 1.26-2.40). In addition, age of symptom onset and frequency of peripheral arthritis significantly differed among AS patients by different OPG G1181C genotypes. HLA-B27+ patients with the OPG C allele had the earliest age of symptom onset. Therefore, OPG G1181C polymorphism may be associated with AS development and clinical manifestations. MicroRNA (miR)-146a targets TNF-receptor-associated-factor-6 (TRAF-6) and interleukin-1 receptor-associated kinase 1 (IRAK1) to suppress nuclear factor kB (NF-kB) activity. We investigated whether miR-146a rs2910164 G/C, IRAK1 rs3027898 A/C and rs1059703 T/C genetic polymorphisms associated with AS development and clinical characteristics. A total of 450 Taiwanese AS patients and 438 healthy controls were recruited in our study. Pairwise analysis of the miR-146a rs2910164/IRAK1 rs3027898 alleles showed G/A (OR 2.84, 95% CI 1.34-6.03), G/C (OR 1.71, 95% CI 1.27-2.30), and C/A (OR 1.53, 95% CI 1.09-2.16) had a significantly greater risk of AS than the C/C alleles. Such results were found in males, but not in females. In addition, AS patients with miR-146a rs2910164/IRAK1 rs3027898 G/A pairwise alleles had a significantly higher risk of uveitis development than patients with miR-146a rs2910164/IRAK1 rs3027898 C/C pairwise alleles. Therefore, miR-146a rs2910164 and IRAK1 rs3027898 polymorphisms might be associated with the development of AS, as well as its clinical manifestations. Tumor necrosis factor (TNF)-α might induce the inflammation and osteoclastogenesis. In addition, miR-125b expression inhibits the TNF-α expression, and higher miR-155 expression inversely induces TNF-α expression by targeting suppressor of cytokine signaling-1 (SOCS-1). We compared the differences of TNF-α mRNA, miR-125b, miR-155, and SOCS-1 mRNA expressions between AS patients and healthy controls. The influence of rheumatologic drugs on the expressions of these molecules in AS patients was also assessed. Expressions of whole blood TNF-α mRNA, miR-125b, miR-155, and SOCS-1 mRNA were assessed by RT quantitative PCR (RT-qPCR) among 119 AS patients and 120 healthy controls. TNF-α mRNA expression was negatively correlated with miR-125b expression (r = -0.63, p = 0.03); positively correlated with Bath Ankylosing Spondylitis Functional Index (r = 0.82, p < 0.01), erythrocyte sedimentation rate (r = 0.70, p = 0.02), and C-reactive protein (r = 0.79, p < 0.01) in AS patients without taking nonsteroidal antiinflammatory drugs (NSAIDs) or disease-modifying antirheumatic drugs (DMARDs), respectively. But TNF-α mRNA expression was not correlated with bone metabolism in AS patients. The binding of miR-21 and programmed cell death 4 (PDCD4) might inhibit the expression of PDCD4, and further induce the activation of osteoclasts. We compared the difference of miR-21 expression between AS patients and healthy controls, and evaluated the relationships of miR-21, PDCD4 mRNA, and bone erosion in AS patients. The influence of rheumatologic drugs on the expressions of miR-21 and PDCD4 mRNA in AS patients was also assessed. The expressions of serum miR-21 and PDCD4 mRNA were assessed by RT-qPCR among 122 AS patients and 122 healthy controls, and serum CTX was detected using enzyme-linked immunosorbent assay (ELISA). Compared to healthy controls, AS patients had significantly higher levels of miR-21, PDCD4 mRNA, and CTX. In AS patients who were taking neither NSAIDs nor DMARDs, miR-21 expression was negatively correlated with PDCD4 mRNA expression. In addition, positive correlation of miR-21 and CTX level was observed in AS patients (r = 0.35, p < 0.001), especially in those with disease duration < 10 years (r = 0.49, p < 0.001) and active disease (r = 0.51, p < 0.001). Bone morphogenic proteins (BMPs), is secreted by osteoblasts, might influence the bone formation in AS. MiR-29 suppresses Dickkopf 1 (DKK1) and secreted frizzled related protein 2 (sFRP2) of the Wingless (Wnt) inhibitors, and miR-27 also suppresses sFRP1, DKK2, and adenomatous polyposis coli (APC) of the Wnt inhibitors to regulate the Wnt signal pathway. When Wnt signal pathway was activated, it might further induced BMPs expression. We compared the differences of miR-29, miR-27, and their target genes expressions between AS patients and healthy controls. The influence of rheumatologic drugs on the expressions of these molecules in AS patients was also assessed. Results observed that 73 patients with spinal fusion had higher serum levels of BMP-4 and BMP-7 than either 62 healthy controls or 79 patients without spinal fusion (ps < 0.01), respectively. AS patients with spinal fusion and those without spinal fusion also had the significantly increased miR-27b, miR-29a, miR-29b, and lower sFRP1 mRNA and sFRP2 mRNA expressions than healthy controls; respectively. Compared to AS patients without receiving drug treatment, those with receiving drug treatment had a lower miR-27b expression Therefore, BMPs, miR-27, and Wnt inhibitor proteins might relate to the bone formation in AS. Cytotoxic T lymphocyte antigen-4 (CTLA-4) and protein tyrosine phosphatase, nonreceptor 22 (PTPN22) might play the roles in the inhibition of activated T cells in the initial period of autoimmune tolerance. Programmed cell death-1(PD-1) binds programmed cell death-1 ligand 1(PD-L1) and ligand 2 (PD-L2) to induce negative signals that might maintain the balance of immune tolerance during late period. Therefore, we evaluated the effects of CTLA-4, PTPN22, PD-1, PD-L1 and PD-L2 genptypes in AS occurrences. Results revealed subjects with both of PTPN22 CC/CTLA-4 AA or PTPN22 GC/CTLA-4 AA genotypes had a 2.10 fold (95% CI 1.07-4.13) greater risk of AS development than those with other combinations of PTPN22 and CTLA-4 genotypes. In addition, subjects carrying combinations of PD-1 GG + GA/PD-L1 CC/PD-L2 CC genotypes, those carrying combinations of PD-1 AA/PD-L1 CC/PD-L2 CC genotypes, and those carrying combinations of PD-1 GG + GA/PD-L1 AC + AA/PD-L2 CC genotypes had 6.63 (95% CI 1.28-34.46), 4.33 (95% CI 0.36-52.64), and 3.05 (95% CI 2.16-4.32) greater risks of AS development than those with other combinations of PD-1/PD-L1/PD-L2 genotypes; respectively. Our results suggest that PTPN22 G-1123C, CTLA-4 A49G, PD-1 G-536A, PD-L1 A8923C, and PD-L2 C47103T genotypes have the combined effects on AS development. In conclusion, bone resorption, bone formation, and imbalance of immune tolerance-related gene and miRNA, and their target genes might associate with the development of AS and clinical syndromes.
Alsendi, Maryam Abdulaziz. "The effect of anti-inflammatory drugs on bone remodeling using ex-vivo cultures of mouse calvarial bone". Thesis, 2020. https://hdl.handle.net/2144/41342.
Pełny tekst źródła"Epimedium Active Component Icaritin Enhances Bone Mass through Regulating the Coupling of Bone Formation and Resorption Mediated by Distinct Signaling Targets". 2016. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292649.
Pełny tekst źródłaSardone, Laura Donata. "The Effect of Rosiglitazone on Bone Quality in a Rat Model of Insulin Resistance and Osteoporosis". Thesis, 2010. http://hdl.handle.net/1807/25786.
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