Rozprawy doktorskie na temat „Bone disease”
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Wedin, Rikard. "Metastatic bone disease /". Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3829-6/.
Pełny tekst źródłaPutman, Melissa. "Cystic Fibrosis Related Bone Disease". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17613728.
Pełny tekst źródłaGoodyear, Simon R. "Physicochemical methods for measuring the properties of bone and their application to mouse models of disease". Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=133992.
Pełny tekst źródłaAbdelhadi, Mohamed Mohamed. "Posttransplantation bone disease : the effect of immunosuppressive drugs on bone: clinical and experimental studies /". Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-384-8/.
Pełny tekst źródłaNixon, Matthew Frank. "Metabolic bone disease and arthroplasty loosening". Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/8448.
Pełny tekst źródłaLucas, Gavin J. A. "Genetics of Paget's disease of bone". Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430978.
Pełny tekst źródłaHocking, Lynne J. "Genetics of Paget's disease of bone". Thesis, University of Aberdeen, 2002. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU160239.
Pełny tekst źródłaHaarhaus, Mathias. "Bone alkaline phosphatase isoforms in chronic kidney disease : mineral and bone disorder". Doctoral thesis, Linköpings universitet, Avdelningen för mikrobiologi och molekylär medicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-111870.
Pełny tekst źródłaPorter, Ryan Michael. "Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration". Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/36365.
Pełny tekst źródłaMaster of Science
Good, David Andrew, i n/a. "Genetic Loci for Paget's Disease of Bone". Griffith University. School of Biomolecular and Biomedical Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040319.125358.
Pełny tekst źródłaAmofah, Eunice. "Bone marrow stem cells in liver disease". Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497234.
Pełny tekst źródłaNajat, Dereen. "SQSTM1 mutations and Paget's disease of bone". Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11118/.
Pełny tekst źródłaBirch, Mark Andrew. "Investigations of bone cells in Paget's disease". Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333632.
Pełny tekst źródłaGood, David Andrew. "Genetic Loci for Paget's Disease of Bone". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/365759.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Biomedical Sciences
Full Text
Obaid, Rami Abdulhadi Abdulmajeed. "Investigating the role of optineurin in bone biology and Paget's disease of bone". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23419.
Pełny tekst źródłaOgilvie, D. J. "The genetics of collagen in brittle bone disease". Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235046.
Pełny tekst źródłaBillah, Ahmed Mohammed El-Motaz. "Markers of bone turnover in health and disease". Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295769.
Pełny tekst źródłaNuman, Mohamed. "Gene-environment interaction in Paget's disease of bone". Master's thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27518.
Pełny tekst źródłaPaget's disease of bone (PDB) is a metabolic bone disease. Although genetic factors play an important role in the pathogenesis of PDB, environmental factors such as rural residence and the exposure to wood heating was associated with PDB. In order to study the role of outdoor and indoor air pollutants on PDB, we performed a survey in 140 French-Canadian patients with PDB and 113 healthy controls. The survey covered the outdoor air pollution such as the residence near a highway, a bus station, a train or an airport or a gas station, and indoor air pollutants by focusing on heating fuels (carbon, wood, oil) and exposure to tobacco smoke. In a subgroup of patients, urinary concentration of 17 heavy metals and 11 polycyclic aromatic hydrocarbons was measured by mass spectrometry. In light of what we knew from the survey and urinary assays, we identified certain toxics that could be risk factors for PDB. To explore the in vitro effects of these toxics on osteoclasts in PDB, we conducted in vitro monocytes differentiation from peripheral blood of more than 40 participants, patients, healthy carriers of p.Pro392Leu mutation, and healthy controls, which osteoclasts were treated with or without the identified toxic. The morphology of osteoclasts, the percentage of bone resorption, gene expression level, and cellular oxidative stress levels were assayed. The results showed an inhibitory effect of cigarette smoke condensate and heavy metals on morphology and function of patients’ osteoclasts. Further, high levels of oxidative stress in patients’ osteoclasts were observed, and a heterogenic profile of heavy metals effect on gene expression was identified.
Gowers, Kate Hayley Christine. "Characterisation of bone marrow progenitor cells in disease". Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11068.
Pełny tekst źródłaOrmarsdóttir, Sif. "Osteoporosis in chronic liver disease /". Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5021-0/.
Pełny tekst źródłaHuang, C. C. "Pathophysiology of post-transplantation bone disease : mechanisms of bone loss after orthotopic liver transplantation". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604707.
Pełny tekst źródłaMacPherson, Heather. "Role of the nitric oxide synthase pathway in bone cell function and bone disease". Thesis, University of Aberdeen, 1999. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU112398.
Pełny tekst źródłaChoi, Chung-yue. "Free radicals and bone marrow diseases a potential role of nitric oxide in graft-versus-host disease after bone marrow transplant /". Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23273367.
Pełny tekst źródłaTaggart, Frances Margaret. "The epidemiology of Paget's disease of bone in Europe". Thesis, University of Southampton, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328623.
Pełny tekst źródłaRios, Visconti Micaela. "Genetic and environmental determinants of Paget's disease of bone". Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/20421.
Pełny tekst źródłaPAOLETTI, Nicola. "Formal Computational Modelling of Bone Physiology and Disease Processes". Doctoral thesis, Università degli Studi di Camerino, 2014. http://hdl.handle.net/11581/401835.
Pełny tekst źródłaBurdon, Peter Charles Edward. "Regulation of neutrophil mobilisation from the bone marrow". Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289739.
Pełny tekst źródłaKawai, Shunsuke. "In vitro bone-like nodules generated from patient-derived iPSCs recapitulate pathological bone phenotypes". Doctoral thesis, Kyoto University, 2020. http://hdl.handle.net/2433/245828.
Pełny tekst źródła0048
新制・課程博士
博士(医学)
甲第22143号
医博第4534号
新制||医||1039(附属図書館)
京都大学大学院医学研究科医学専攻
(主査)教授 妻木 範行, 教授 森本 尚樹, 教授 別所 和久
学位規則第4条第1項該当
Doctor of Medical Science
Kyoto University
DFAM
Uno, Jennifer Kikue. "Bone Mineralization in a Murine Model of Inflammatory Bowel Disease". Diss., Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1650%5F1%5Fm.pdf&type=application/pdf.
Pełny tekst źródłaDaroszewska, A. "Role of osteoprotegerin and p62 in Paget's disease of bone". Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.590957.
Pełny tekst źródłaNicholas, Richard Martin. "A laboratory and clinical study of Paget's disease of bone". Thesis, Queen's University Belfast, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317547.
Pełny tekst źródłaGreenland, William Edward Peverell. "Radionuclide conjugates of calcitonin for imaging bone disease and cancer". Thesis, University of Kent, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252555.
Pełny tekst źródłaVan, den Broek Dirk Hendrik Nicolaas. "Mineral and bone disorder in cats with chronic kidney disease". Thesis, Royal Veterinary College (University of London), 2018. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766340.
Pełny tekst źródłaMiddleton, Anna. "Whole body vibration training in chronic disease: muscle, bone, function". Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20714.
Pełny tekst źródłaPatterson, Catherine Elizabeth. "Histomorphometry-based modeling and simulation of multiple myeloma bone disease". Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3161.
Pełny tekst źródłaFrith, Julie C. "Studies into the mechanism of action of clodronate". Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299577.
Pełny tekst źródłaVinholes, Jeferson Jose Fonseca. "Effects of bone metastases on bone metabolism : implications for assessment of response to bisphosphonates and systemic anti-cancer therapy". Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264749.
Pełny tekst źródłaPan, Beiqing. "Mechanisms of skeletal disease mediated by haematological malignancies /". Title page, table of contents and abstract only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09php1871.pdf.
Pełny tekst źródła"August 2004" Errata inside front cover. Bibliography: leaves 126-159.
Phan, Tuan (Tony). "Functional characterisation of an osteoclast-derived osteoblastic factor (ODOF)". University of Western Australia. School of Surgery and Pathology, 2004. http://theses.library.uwa.edu.au/adt-WU2005.0028.
Pełny tekst źródłaMkukuma, Lovemore D. "Characterisation of the material properties of bone in health and disease". Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252126.
Pełny tekst źródłaHjorth-Hansen, Henrik. "Novel cytokines in growth control and bone disease of multiple myeloma". Doctoral thesis, Norwegian University of Science and Technology, Faculty of Medicine, 2001. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-315.
Pełny tekst źródłaMyelomatose (benmargskreft) er en blodsyk dom som rammer ca 200 nordmenn årlig. Sykdommen kan ikke kureres og karakteriseres av symptomer som benmargssvikt og infeksjonstendenns, men kanskje først og fremst av sykelig nedbrytning av skjelettet. Pasientene rammes i høy utstrekning av benbrudd, hvirvelsammenfall og skjelettsmerter. Mekanismene for bennedbrytning og vekstkontroll står sentralt i avhandlingsarbeidet som består av fem artikler om cytokiners rolle i myelomatose. Cytokiner er signalsubstanser som benyttes i celle-celle-kommunikasjon. Det er sannsynligvis ubalanse av cytokiner som forårsaker den sykelige nedbrytningen av bensubstansen.
Det første delarbeidet omhandler funnet av hepatocyttvekstfaktor (HGF) som er uttrykt hos nesten alle pasienter med myelomatose Dette påvises med forskjellige teknikker og det benyttes bl a en separasjonsmetode for myelomceller basert på Ugelstadkuler som ble utviklet ved IKM i 1993. Videre påvises forhøyede nivåer av HGF i serum fra pasienter. Et interessant funn er at HGF reseptor også er uttrykt i pasientprøver, hvilket kan tale for at myelomceller kan ha en selvstimulerende (autokrin) funksjon.
I det andre delarbeidet vises en dyremodell for myelomatose i immundefekte mus. Et hovedpoeng er at det lar seg gjøre å få vekst av myelomceller i musebenmarg med påvisbare tegn til patologisk bennedbrytning på røntgen og ved histologisk undersøkelse. Musene har forhøyede nivåer av HGF i serum. Benlesjonene ble karakterisert ved hjelp av histomorfometri. Denne undersøkelse viste 99% reduksjon av de bendannende cellene (osteoblaster) og 33% reduksjon av bennedbrytende celler (osteklaster).
I tredje delarbeidet viser man at HGF induserer interleukin (IL)-11-produksjon i osteoblaster. IL-11 er en kjent påskynder av benresorpsjon og osteoklastaktivator. Et interessant fenomen er at HGF ser ut til å være bundet til heparansulfat på cellemembranen og at slikt membranbundet HGF virker bedre enn løselig HGF. Effekten av HGF potensieres av cytokinene TGF-beta og IL-1. En styrke ved arbeidet er at såvel ferskisolerte pasientceller som cellelinjer viser identiske mønstre. Arbeidet angir en mulig måte som HGF kan befremme bennedbrytning.
I fjerde delarbeid vises at cytokinet IL-15 forhindrer programmert celledød (apoptose) i myelomcellelinjen OH-2. Det var fra før kjent at myelomceller relativt hyppig lar seg stimulere av cytokinet IL-6, som fortsatt er den mest anerkjente myelomvekstfaktoren. IL-15 var tilnærmet like potent antiapoptotisk som IL-6, og befremmet også kortvarig proliferasjon. IL-15s effekt kunne potensieres av TNF-alfa
I femte delarbeid påvises at cytokinet benmorfogent protein (BMP)-4 hemmer vekst av myelomceller. BMP-4 befremmer bendannelse. Effekten av BMP-4 kom fram i IL-6-stimulerte cellelinjer og pasientprøver. Effekten skyldtes såvel induksjon av apoptose som stopp i cellesyklus G1-fase. Dette er et mulig viktig funn siden man kan tenke seg at pasienter med myelomatose kunne behandles med BMP-4 eller lignende substanser. På slik måte ville såvel skjelettnedbrytningen som myelomcellevekst kunne påvirkes gunstig.
Arbeidet bidrar til forståelse av molekylære mekanismer for bendestruksjon og myelomcellevekst og ble veiledet av profesor dr. med. Anders Waage. Henrik Hjorth-Hansen har vært stipendiat i Den norske kreftforening, og undersøkelsen ble dessuten støttet av Kreftfondet ved RiT og Blix’ legat.
Ivanauskaitė, Deimantė. "Alveolar bone loss in radiographic modalities for diagnosis of periodontal disease". Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110621_164329-13939.
Pełny tekst źródłaRentgeniniai tyrimo metodai taikomi, kad būtų papildyti klinikinio tyrimo duomenys. Tiriant periodontą, kurį sudaro dantenos, dantinė atauga, periodonto raiščiai ir cementas, rentgeninis tyrimas svarbus diagnozuojant periodonto ligas, nes jo metu nustatomi dantinės ataugos pokyčiai. Dantinės ataugos pokyčiams vertinti daromos rentgeno nuotraukos taikant vidinių burnos rentgeno nuotraukų darymo metodus, t. y. kandimo ar dantų šaknų rentgeno nuotraukų darymo metodus, ir išorinės burnos rentgeno nuotraukos darymo metodą, t. y. panoraminės rentgeno nuotraukos darymo metodą. Atlikus dantinės ataugos pokyčių (kaulo lygio arba rezorbcijos, kaulo defekto ir tarpšaknio kaulo pažeidimų) analizę, taikant rentgeninius metodus, ir padarius sisteminę literatūros apžvalgą, galima būtų pasiūlyti tinkamiausią rentgeno metodą periodonto ligoms diagnozuoti. Šio darbo tikslas – ištirti ir palyginti panoraminės rentgeno nuotraukos ir kaplių bei krūminių dantų rentgeno nuotraukų darymo metodų diagnostikos ypatybes vertinant dantinės ataugos pokyčius periodonto ligoms diagnozuoti. Kiekvienam, iš 96 pacientų įtrauktų į tyrimą, buvo padaryta panoraminė rentgeno nuotrauka ir kaplių bei krūminių dantų kandimo rentgeno nuotraukos. Atlikta dantinės ataugos rentgeno atvaizdo vizualioji kokybė analizė ir vertinimai skirtingose rentgeno nuotraukose bei palyginti rezultatai. Padaryta sisteminė literatūros apžvalga apie panoraminės rentgeno nuotraukos vertę diagnozuojant periodonto ligas. Pagal šio tyrimo... [toliau žr. visą tekstą]
Lin, Feng. "Minimal residual disease after bone marrow transplantation for chronic myeloid leukaemia". Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285196.
Pełny tekst źródłaMessiou, Christina. "Investigation of quantitative biomarkers of treatment response in malignant bone disease". Thesis, Institute of Cancer Research (University Of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538326.
Pełny tekst źródłaParker, Cornelle R. "Evaluation of renal bone disease in transplant recipients and related conditions". Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342044.
Pełny tekst źródłaAppleman, Stephanie S. M. D. "Bone Disease in TPN-dependent Infants and Children with Intestinal Failure". University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1320326652.
Pełny tekst źródłaHadi, Tamer. "THE ROLE OF p62 IN OSTEOCLASTOGENESIS AND PAGET’S DISEASE OF BONE". VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/3312.
Pełny tekst źródłaLaslett, Laura Louise. "Screening for low bone mineral density in patients with respiratory disease". Title page, table of contents and abstract only, 2003. http://web4.library.adelaide.edu.au/theses/09MSB/09msbl3456.pdf.
Pełny tekst źródłaIrani, Dilshad Minocher. "Role of the surface associated material of Eikenella corrodens in bone resorption associated with periodontal disease : a research thesis submitted in fulfilment of the requirements for the degree of Master of Science in Dentistry". Title page, contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09DSM/09dsmi65.pdf.
Pełny tekst źródłaMartinelli, Mark J. "Morphometric analyses of bone and cartilage of the equine metacarpophalangeal joint". Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284973.
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