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Pretorius, S. M. "Feedback to patients with low bone mineral density after bone densitometry". Thesis, Bloemfontein : Central University of Technology, Free State, 2006. http://hdl.handle.net/11462/70.
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Thesis (M. Tech.) -- Central University of Technology, Free State, 2006Osteoporosis is defined as a skeletal disorder characterised by low bone mass and micro-architectural deterioration of bone tissue, with the overall focus on bone quality. It affects more than 75 million people worldwide, and cause people to become bedridden with life threatening secondary complications. An estimated 10 million South Africans, out of a population of 43 million people, are at high risk of developing osteoporosis. In South Africa osteoporosis affects one in three women over 50 and one in five men. Within one year after a hip fracture, up to 20% of the people die, 15-20% needs to be institutionalised and 50% of the remainder will not be able to lead an independent life. The number of fractures is two to three times higher in women than in men due to the hormonal changes that occur after menopause. The prevalence of osteoporosis increases markedly with age and, based on the bone mineral density at the femoral neck of the hip, approximately 30% of Caucasian women, by age of 75 years will be classified as having osteoporosis. Dual-Energy X-ray Absorptiometry (DEXA) is the preferred method for measuring BMD. The results of the DEXA scan are scored in comparison with the BMD of young, healthy individuals, resulting in a measurement called a T-score. A T-score of –2.5 or lower is considered to be osteoporosis and T-scores between –0.1 and –2.5 are generally considered to show osteopenia. The aim of the study was to examine communication between referring physicians and patients who had been referred for a DEXA scan. A total of fifty patients were included in the study group. This was much smaller than was anticipated. The ideal would have been a much bigger sample group for a bigger representation of the population. Patients, who complied with the inclusion criteria and also gave their consent, were recruited between January 2004 and November 2004. Not all the patients referred for a DEXA scan had the required low BMD. Bone scans were performed on the HOLOGIC 4500 QDR, a multiple detector, fan beam, Dual Energy X-ray Densitometer. The Hologic 4500 QDR Bone Densitometer estimates the Bone Mineral Content (BMC) in grams, and the BMD in grams per cm2. The QDR 4500 uses a low level of X-rays with two different energies to estimate BMC and BMD. The radiation exposure at a distance of two metres from the equipment is less than one mR/hour. The age distribution of the study group ranged between 14 and 84 years (average age was 57,2 years). Out of the total of 50 patients, only one was male and the entire patient population was Caucasian. This may be due to the small sample size and inclusion/exclusion criteria. Concerning the references of the patient population, Universitas Academic Hospital (UAH) referred more than half of the patients (64%), while the other points of care referred only 36%. In this study, it was found that BMD results do influence the management of osteopenia/osteoporosis in the majority of patients and the test has a positive impact on the management of patients with this condition. There was however 22% of patients that did not receive feedback concerning the results of the DEXA and the necessary treatment. These findings also highlighted the fact that communication between physician and patient is a very important component in using the information provided by this test to its full potential. The ideal is to identify a low BMD early enough to stop the damaging consequences thereof, but this is not always feasible due to the high costs involved in a DEXA scan. Access to treatment and care is also not readily available to a large section of the population and, in State Hospitals; the availability of drugs to treat osteoporosis is limited due to the high costs.
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Cho, Helen. "Age-associated bone loss in an imperial roman population : an histological analysis of inter-skeletal and intra-skeletal variability /". free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3052164.
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Herd, Ruth Jane Margaret. "Bone densitometry studies of skeletal response to cyclical etidronate". Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244086.
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Kilbarger, Amy K. "The effect of iron overload on osteoblast function in cell culture". Greensboro, N.C. : University of North Carolina at Greensboro, 2007. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=146.
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Thesis (M.S.)--University of North Carolina at Greensboro, 2007.Title from PDF t.p. (viewed Feb. 29, 2008). Directed by Deborah Kipp; submitted to the School of Human Environmental Sciences. Embargoed until Dec. 20, 2008. Includes bibliographical references (p. 47-56).
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Pomchote, Porrawee. "Age-related changes in bone morphometry, densitometry and osteoarthritis in macaques". 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199154.
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Mossop, J. R. "Coherent gamma-ray scattering and transmission measurements in bone densitometry". Thesis, University of Surrey, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383627.
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Lau, Hoi-lun. "Genetic and environmental determinants of bone mineral density in Southern Chinese". Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31930633.
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Gardina, Christopher Hazelwood Scott James. "Bone mass preservation and fracture risk assessment with bisphosphonate therapy during spaceflight : a thesis /". [San Luis Obispo, Calif. : California Polytechnic State University], 2008. http://digitalcommons.calpoly.edu/theses/5/.
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Thesis (M.S.)--California Polytechnic State University, 2008.Major professor: Scott Hazelwood, Ph.D. "Presented to the faculty of California Polytechnic State University, San Luis Obispo." "In partial fulfillment of the requirements for the degree [of] Master of Science in Engineering with a specialization in Biomedical Engineering." "June 2008." Includes bibliographical references (leaves 46-49). Also available online. Also available on microfiche (2 sheets).
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Zagarins, Sofija E. "Determinants of peak bone mass in young adult women". Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/dissertations/AAI3372286/.
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Carter, John. "Quantitative aspects of computed tomography with particular reference to bone densitometry". Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376131.
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To, Wing-kee William, i 杜榮基. "Use of quantitative ultrasound for assessment of bone mineral density changes in pregnancy and its relationship to pregnancy and perinatalcharacteristics". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46448238.
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Ryan, Timothy Michael. "The structure and function of trabecular bone in the femoral head of strepsirhine primates". Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3023558.
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Liu, Ning. "Bayesian Nonresponse Models for the Analysis of Data from Small Areas: An Application to BMD and Age in NHANES III". Link to electronic thesis, 2003. http://www.wpi.edu/Pubs/ETD/Available/etd-0428103-145502/.
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Patel, Rajesh. "An evaluation of peripheral bone densitometry in the management of osteoporosis in women". Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423324.
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Bastos-Silva, Yasmin 1990. "Correlação do risco de fratura osteoporótica em 10 anos calculado pelo FRAX com e sem densitometria em mulheres brasileiras na pós menopausa = Correlation between osteoporotic fracture risk in 10 years calculated by FRAX with and without bone densitometry in post menopause brazilian women". [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312826.
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Orientador: Lúcia Helena Simões da Costa PaivaDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-27T21:42:31Z (GMT). No. of bitstreams: 1 Bastos-Silva_Yasmin_M.pdf: 1080942 bytes, checksum: 7599dbea7c337dddf84a74226180fc92 (MD5) Previous issue date: 2015
Resumo: O risco de fratura osteoporótica pode ser avaliado clinicamente baseado em fatores clínicos e pela densidade mineral óssea (DMO), entretanto esses parâmetros não são bons preditores do risco de fratura. Recentemente, o Brasil foi incluído no instrumento fracture risk assessment tool- FRAX-BRASIL, porém seu uso tem sido limitado na prática clínica. OBJETIVO: Avaliar o grau de concordância entre o risco de fratura em 10 anos calculado pelo FRAX-BRASIL com e sem densitometria em mulheres brasileiras na pós-menopausa. MÉTODO: Realizou-se um estudo de corte transversal no período de novembro de 2014 a fevereiro de 2015, com 402 mulheres em acompanhamento no Ambulatório de Menopausa do Hospital da Mulher Prof. Dr. José Aristodemo Pinotti em Campinas-SP. Foram incluídas mulheres com 40 anos ou mais, em amenorreia há pelo menos 12 meses e com exame de densitometria óssea prévio a qualquer tratamento medicamentoso para osteopenia ou osteoporose. As mulheres foram entrevistadas por um pesquisador durante a consulta de rotina, na qual foram coletadas informações sobre fatores de risco necessários para o questionário FRAX-BRASIL e dados da densitometria óssea. Os dados obtidos foram inseridos na plataforma online FRAX-BRASIL, em que foi calculado o risco para uma fratura maior e de quadril, utilizando-se somente os fatores de risco clínicos e o risco incluindo valores de DMO do colo do fêmur em g/cm2. ANÁLISE ESTATÍSTICA: Para análise do grau de concordância entre os riscos de fraturas com e sem densitometria óssea foi utilizado o coeficiente de correlação intraclasse (ICC). O Teste de Mann-whitney foi utilizado para comparação entre as médias do risco de fratura calculado com e sem DMO; para comparação entre as frequências de alto risco calculadas com e sem DMO foi utilizado o Teste de comparação entre duas proporções. Para análise da associação entre as variáveis clinico/demográficas e a variação do risco de fratura foi utilizada a análise de regressão linear. O nível de significância adotado foi <0,05. RESULTADOS: A probabilidade de fratura em 10 anos calculada pelo FRAX-BRASIL para fratura de quadril e para fratura maior somente pelos fatores de risco clínicos foi de 0,84% ±1,92 e 4,03% ±2,98 e com DMO foi de 0,83% ±1,76 e 4,05% ±2,98 respectivamente. O coeficiente de correlação intraclasse entre o FRAX-BRASIL com e sem DMO foi de 0,76 (IC95% 0,716-0,799) para uma fratura maior e de 0,644 (IC95% 0,583-0,698) para fratura de quadril. Ao avaliar as mulheres utilizando o FRAX com DMO 0,75% e 5,22% excederam os limiares de alto risco para fratura maior e de quadril, respectivamente. Sem o acréscimo da densidade óssea 1% e 11,44% apresentaram alto risco para fratura maior e de quadril, respectivamente. Dessa forma a recomendação de tratamento foi concordante entre o FRAX com e sem DMO em 99,75% dos casos de alto risco de fratura maior e de 93,78% para o quadril. Os fatores associados a menor variação FRAX com e sem foram maior idade, menor DMO, menor T-score e ausência de fratura previa tanto para fratura maior como para quadril. O menor IMC esteve associado a menor variação do FRAX apenas para fratura maior. CONCLUSÃO: O risco de fratura maior ou de quadril foi baixo na população estudada. O FRAX-BRASIL apresentou alta concordância para estimar o risco de fratura maior e concordância moderada para fratura de quadril apresentando uma estimativa de risco para fratura semelhante com ou sem DMO em nossa população
Abstract: The risk of osteoporotic fracture can be clinically evaluated based on clinical factors and by the bone mineral density (BMD), but these parameters are not good predictors of fracture risk. Recently, Brazil was included in the fracture risk assessment tool- FRAX-BRAZIL, but its use has been limited in clinical practice. GOAL: To evaluate the degree of correlation between the degree of correlation between the risk of fracture in 10 years calculated by FRAX-BRAZIL with and without densitometry in Brazilian postmenopausal women. METHODS: A cross-sectional study was conducted with 402 women followed up at the Menopause Ambulatory at the Women's Hospital Prof. Dr. José Aristodemo Pinotti in Campinas-SP. Women were included with 40 years or more in amenorrhea for at least 12 months and with bone densitometry exam prior to any drug treatment for osteopenia or osteoporosis. A researcher interviewed the women during a routine visit, where information about risk factors necessary for the FRAX-BRAZIL questionnaire and data of bone densitometry were collected. The collected data were inserted on the online platform FRAX-BRAZIL where the risk for major fractures and of the hip using only clinical risk factors and the risk including femoral neck BMD values in g / cm2. STATISTICAL ANALYSIS: To analyze the degree of correlation between the risk of fractures with and without bone densitometry was used the intraclass correlation coefficient (ICC). The Mann-Whitney test was used to compare the averages of fracture risk calculated with and without BMD; to compare the frequencies of high risk calculated with and without BMD was used the compare Test between two proportions. For analysis of the association between clinical / demographic variables and the change of the fracture risk was used linear regression analysis. The significance level was <0.05. RESULTS: The fracture probability calculated in 10 years by using the FRAX-BRAZIL for hip fracture and major fracture only by clinical risk factors was 0.84% ± 1.92 and 4.03 ± 2.98% and BMD was 0.83% ± 1.76 and 4.05 ± 2.98%, respectively. The intraclass correlation coefficient between the FRAX-BRAZIL with and without BMD was 0.76 (IC95% 0.716-0.799) for a major fracture and 0.644 (IC95% 0.583-0.698) for hip fracture. When evaluating women using FRAX with BMD 0.75% and 5.22% exceeded the high-risk thresholds for major and hip fracture, respectively. Without the increase of the bone density 1% and 11.44% presented high risk for major fractures and of hip, respectively. Then the treatment recommendation was consistent between the FRAX with and without BMD in 99.75% of cases of high risk of major fracture and 93.78% for the hip. Factors associated with less variation FRAX with and without were older, lower BMD, lower T-score, and no previous fracture both for major fracture as to hip fracture. The BMI was associated with lower variation in the FRAX only to major fracture. CONCLUSION: The risk of major fracture or of the hip was low in the study population. The FRAX-BRAZIL presented a high correlation to estimate the risk of major fractures and moderate agreement for hip fracture presenting a risk estimate for similar fracture with or without BMD in our population. The FRAX-BRAZIL presented a high correlation to estimate the risk of major fractures and moderate correlation for hip fracture presenting a risk estimate for similar fracture with or without BMD in our population
Mestrado
Fisiopatologia Ginecológica
Mestra em Ciências da Saúde
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Miranda, Lituania Fialho de. "Estabelecimento de um índice quantitativo e qualitativo para auxiliar no diagnóstico da osteoporose em radiografia panorâmica". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/23/23139/tde-19032015-111208/.
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Recentemente, a osteoporose tem sido apontada como fator associado a manifestações bucais representadas pela perda óssea, especialmente na mandíbula. Entretanto, as técnicas de avaliação direta da densidade mineral óssea mandibular ainda não demonstraram boa precisão e acurácia. O presente trabalho teve como objetivo avaliar, por meio de um estudo descritivo-analítico, a possibilidade da utilização das radiografias panorâmicas, como um método capaz de expressar as alterações morfológicas da mandíbula decorrentes da idade e estabelecer um único índice quantitativo e qualitativo, para identificar os casos de osteopenia e osteoporose. A pesquisa ocorreu em mulheres em período de menopausa e pós-menopausa em tratamento odontológico nas clínicas odontológicas da faculdade de Odontologia da Universidade de São Paulo, no município de São Paulo SP. A confirmação do diagnóstico da osteoporose foi estabelecida mediante verificação dos relatórios da densitometria de antebraço obtidos, e comparados aos diagnósticos obtidos nas radiografias panorâmicas para o estabelecimento de um único índice quantitativo e qualitativo que considere a reabsorção e a baixa espessura da cortical na avaliação. O novo Índice Panorâmico Quantitativo e Quantitativo (IPQQ) foi determinado. A concordância entre as duas avaliações, calculada como razoável, reflete sensibilidade (moderada) de 56%, especificidade (satisfatória) de 82% e VPN (Valor Preditivo Negativo) de 68%. O IPQQ apresentou associação e concordância significativa com a densitometria (padrão ouro) podendo ser utilizado como teste para o rastreamento, porém cuidados ou algumas restrições deverão ser tomados em sua utilização, pois a intensidade de concordância razoável foi devida a uma moderada sensibilidade deste teste em relação ao padrão ouro.Recently, osteoporosis has been implicated as being associated with oral manifestations represented by bone loss, especially in the jaw. However, the techniques of direct assessment of mandibular bone mineral density has not demonstrated good accuracy and precision. This study aimed to evaluate, through a descriptive and analytical study, the possibility of the use of panoramic radiographs as a method to express the morphological changes of the jaw due to age and to establish a single index quantitatively and qualitatively, to identify cases of osteopenia and osteoporosis. The research period occurred in women in menopause and postmenopause in dental treatment in dental clinics of the Faculty of Dentistry, University of São Paulo, in São Paulo - SP. Confirmation of the diagnosis of osteoporosis was established by scanning densitometry reports obtained from the forearm, and compared the diagnoses obtained from panoramic radiographs for the establishment of a single index that considers both quantitative and qualitative resorption and lower cortical thickness in the assessment. The new Quantitative and Quantitative Panoramic Index (QQPI) was determined. The agreement between the two assessments, calculated as reasonable, reflects sensitivity (moderate) 56%, specificity (satisfactory) to 82% and NPV (Negative Predictive Value) of 68%. The QQPI showed significant association and agreement with densitometry (gold standard) can be used as a test for the screening, but some restrictions or care should be taken into use, because the intensity of reasonable agreement was due to a moderate sensitivity of this test in compared to the gold standard.
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Soares, Alessandra. "Minerais orgânicos na alimentação de potros". Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/10/10135/tde-17012008-162818/.
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O objetivo do trabalho foi avaliar o uso de minerais orgânicos na alimentação de potros, avaliando a deposição óssea de Cálcio e Fósforo, através de biopsia e densitometria óssea, além das medidas de crescimento, de altura da cernelha e da garupa, perímetro torácico, joelho, canela e ganho de peso. Foram utilizados dez potros com idade entre 10 e 13 meses e peso aproximado de 221 kg, distribuídos aleatoriamente em dois tratamentos: dieta formulada com minerais orgânicos e dieta formulada com minerais inorgânicos, com cinco repetições por tratamento. A dieta foi composta de 40% de volumoso, feno de gramínea e 60% de concentrado, a qual foi adicionada 3% da mistura mineral orgânico ou inorgânico. Não foi observada diferença entre os tratamentos em relação ao consumo da deita, medidas de crescimento, e deposição óssea de cálcio e fósforo. No entanto, a deposição óssea dos animais do tratamento orgânico foram maiores quando comparada com as médias do tratamento inorgânico. Entretanto para a variável densitometria, a deposição óssea dos potros alimentados com fonte orgânica foi maior aos 90 dias, quando comparado com todos os animais do tratamento com fonte inorgânica. Os animais do tratamento orgânico apresentaram melhor ganho de peso médio e diário em relação aos animais que receberam mineral inorgânico.The aim of this study was to evaluate the effects of mineral organic in the diet of foals, evaluating the bone mineral deposit of calcium and phosphorus, throughout biopsy and bone mineral density, measures of growing was also did measuring height withers and croup, thoracic circumference, knee, cannon and weight gain. Ten foals which approximated 10 and 13 months and almost 221 Kg weight each one were spread randomly into two treatments: diet with organic mineral and diet with inorganic mineral both with five repetitions for treatments. The diet were composed by 40% of roughage and 60% for concentrate, with was addition 3% of mixed mineral organic or inorganic. It was not detected any for consumption of diet, either for measures of growing and bone mineral concentration of calcium and phosphorus. Nevertheless, the average bone mineral concentration for organic treatment was better than mineral inorganic supplementation. However, the concentration in bone mineral was greater for organic treatment which was better for bone mineral density and weight. The bone deposition was better in 90 days of treatment. Therefore, the diet with organic mineral for foals probably better for bone mineral density and weight gain.
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Albers, Michelle Marie. "Assessment and description of bone density in subjects following chronic therapy with nifedipine /". The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487326511714121.
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Cheung, Ching-lung. "Genetic linkage and association studies to identify candidate genes for bone mineral density variation in Southern Chinese". Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/b40203281.
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Stewart, Kenneth J. "Morphological and biomechanical effects of distraction rate and Insulin-like Growth Factor-1 in distraction osteogenesis of the rabbit mandible". Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297465.
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The effects of the rate of distraction and of local infusion of IGF-1 upon bone deposition during mandibular distraction osteogenesis was studied in a rabbit model. Five groups of rabbits were studied. All rabbits, except sham operated controls, underwent distraction to 15 mm. The variables studied were the rate of distraction (0.5 mm twice a day versus 1.5 mm twice a day) and the effects of local IGF-1 infusion via osmotic infusion pumps. Analysis by DEXA scanning and three point bending 28 days after the end of distraction demonstrated no difference in density or strength of bone between the experimental groups. Histological examination demonstrated non-union across the distraction gap to be more common in rapidly distracted rabbits. Histomorphometric analysis demonstrated higher mineral apposition rates and less un-mineralised osteoid with slow as opposed to rapid distraction (p = 0.0001). Infusion of exogenous IGF-1 also resulted in a small increase in mineral apposition rate which was significant at slow but not a rapid distraction. Bone densitometry and three point bending results did not reveal any effect of distraction rate or IGF-1 infusion other than greater stiffness associated with IGF-1 infusion during rapid distraction (p = 0.01). It seems probable that the overwhelming stimulus to new bone formation produced by distraction renders the anabolic effects of IGF-1 less significant making it detectable by only the more sensitive analysis. This may be due to maximal stimulation of IGF-1 production by slow distraction thus rendering the administration of exogenous IGF-1 relatively superfluous. Rapid distraction may produce less stimulus to growth factor synthesis or the level of production maybe insufficient to cope with a higher requirement. The complete union of rapidly distracted rabbits who received exogenous IGF-1 may be as a result of levels being restored to optimal.
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Lau, Hoi-lun, i 劉海倫. "Genetic and environmental determinants of bone mineral density in Southern Chinese". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31930633.
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Calixto, Jimmy Cavalcanti. "Influência da administração local de sinvastatina na reparação óssea em calvária de ratos". Universidade de Taubaté, 2007. http://www.bdtd.unitau.br/tedesimplificado/tde_busca/arquivo.php?codArquivo=477.
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Diversas alternativas terapêuticas têm sido propostas para a reparação de defeitos ósseos, associadas à cirurgia, como enxertos autógenos, alógenos e aloplásticos, plasma rico em plaquetas e alguns medicamentos. Recentemente foram publicados diversos trabalhos relatando correlação entre o uso de estatinas, medicamentos usados como redutores do nível de colesterol sangüíneo e neoformação óssea. O objetivo deste trabalho foi avaliar o efeito do tratamento local com sinvastatina na reparação de defeitos em calota craniana de ratos. Foram utilizados 48 ratos, nos quais foram confeccionados dois defeitos ósseos de 5mm de diâmetro, um em cada parietal. Os animais foram divididos em três grupos de acordo com o material utilizado no defeito: controle, em que o defeito não foi tratado; sinvastatina, esponja de colágeno embebida com sinvastatina; e carreador, esponja de colágeno e água destilada. O sacrifício ocorreu após trinta ou sessenta dias; as calotas foram removidas, submetidas a exames radiográficos e à preparação histológica de rotina, sendo então realizada análise densitométrica da área do defeito ósseo e histométrica da área de neoformação óssea, com auxílio de um programa computacional para análise de imagens. Os dados foram submetidos à ANOVA e teste t de Student. Tanto na análise densitométrica, como na histométrica, verificouse ausência de diferença estatística entre os três grupos, em cada período experimental. Aos sessenta dias, os animais do grupo controle apresentaram formação óssea superior que aos trinta dias, o que não aconteceu com aqueles que receberam sinvastatina ou apenas o carreador. Clinicamente, verificou-se formação de crosta necrótica nos animais do grupo sinvastatina. Concluiu-se, de acordo com a metodologia utilizada, que a sinvastatina administrada localmente prejudicou a reparação de defeitos experimentais em calvária de ratos.Several therapeutic alternatives have been proposed for the healing of bone defects, associated to the surgery, like autogenous, allogeneous and aloplastic grafts, plasma rich in plaques and some drugs. Recently several works were published reporting correlation between the use of statins, drugs used to reduce the level of blood cholesterol, and bone neoformation. The aim of this work was to evaluate the effect of the treatment with simvastatin, locally administered, in the healing of rat calvarial bone defects. There were used 48 rats, in which there were made two bone defects of 5 mm of diameter, one in each parietal bone. The animals were divided in three groups according to the material used in the defect: control, in which the defect was not treated; simvastatin, sponge of collagen soaked with simvastatin; and carrier, sponge of collagen and distilled water. The sacrifice took place after thirty or sixty days; the skulls were removed, subjected to radiographic examinations and to the routine histological preparation, then histometric analysis of the area of the bone defect was carried out, with support of a software for analysis of images. The data were subjected to the ANOVA and test t of Student. Both in the densiometric and in histometric analysis, it was verified the absence of statistical difference between the three groups, in each experimental period. At sixty days, the control animals presented more bone formation than in thirty days, which did not happen with those who received simvastatin or just the carrier. Clinically, it was verified formation of necrotic crust in the animals of the simvastatin group. One concluded, according to the methodology used, that the simvastatin administered locally harmed the repair of experimental defects in calvaria of rats.
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Xiao, Sumei. "Genome-wide association study of bone mineral density in Chinese". Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43703628.
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Silva, Aneliza de Fatima Moraes da [UNESP]. "Estudo do consumo excessivo de aguardente de cana de açúcar na densidade mineral, espessura e resistência às fraturas ósseas em fêmures e tíbias de ratos adultos-jovens". Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/148635.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O consumo excessivo de bebidas alcoólicas pode ocasionar problemas econômicos, sociais e psicológicos, além de ser prejudicial a muitos órgãos e tecidos, incluindo o tecido ósseo. O álcool é um fator de desequilíbrio entre a formação e a reabsorção óssea, entre osteoblastos e osteoclastos. Este estudo teve como objetivo analisar os efeitos do consumo excessivo de álcool no tecido ósseo de ratos tratados com aguardente de cana de açúcar (cachaça), através da análise de fêmures e tíbias de ratos adultos-jovens. 24 ratos foram utilizados (Rattus norvegicus, albinus, Wistar), divididos em 4 grupos de 6 animais, separados aleatoriamente, sendo: – Grupo com 90 dias de tratamento, grupo controle (GC90) e grupo experimental (GE90); e grupo com 105 dias de tratamento, grupo controle (GC105) e grupo experimental (GE105). Após tratamento e eutanásia, os fêmures e tíbias foram submetidos as análises radiográficas, densitometria óssea e teste biomecânico, respectivamente, avaliados através do Sistema Digital Digora, DEXA (Dual-Energy X-ray Absorptiometry) e Ensaio mecânico. Os dados obtidos foram submetidos ao teste homocedasticidade com significância de 5% e realizada análise de variância – ANOVA- two-way e pós-teste Tukey. Os animais dos grupos controles apresentaram maior espessura óssea total e cortical, maior densidade óssea e conteúdo mineral ósseo (p<0,05), assim como maior resistência a fraturas comparados com os grupos experimentais. Ainda, observou-se que além do padrão de consumo os efeitos do etilismo sobre o tecido ósseo são influenciados pelo tempo de exposição ao álcool. Conclui-se, assim, que o consumo excessivo de aguardente de cana de açúcar além de ocasionar danos ao tecido ósseo, exerce efeito dose dependente nos parâmetros estudados em ratos adultos-jovens.
The excessive consumption of alcoholic beverages can cause economic, problems social and psychological, in addition to being harmful to many organs and tissues, including the bone tissue. Alcohol is a factor of an imbalance between the formation and bone resorption, between osteoblasts and osteoclasts. This study aimed to analyze the effects of excessive alcohol consumption in bone tissue of rats treated with Sugarcane brandy (Sugarcane liquor, aqua vitae), through examinations of femurs and tibias. Twenty-four animals were used (Rattus norvegicus, albinus, Wistar) were divided in 4 groups of 6 animals, randomly divided into: - Group with 90 days of treatment, control group (GC90) and experimental group (GE90); and group with 105 days of treatment, control group (GC105) and experimental group (GE105). After treatment and euthanasia, the femurs and tibias radiographic analyzes were submitted, bone densitometry and biomechanical test, respectively, evaluated by Digora Digital System, DEXA (Dual-Energy X-ray Absorptiometry) and mechanical testing. The data were submitted to the homoscedasticity test with 5% significance and performed analysis of variance - ANOVA- two-way and Tukey test. Control group animals showed higher total and cortical bone thickness, higher bone density and bone mineral content (p<0,05), as well as greater resistance to fractures comparad to the experimental groups. Furthermore, it was observed that in addition to the consumption pattern, the effects of alcohol on bone tissue are influenced by the time of exposure to alcohol. Concluded that the excessive consumption of Sugarcane brandy besides causing damage to the bone tissue exerts dose-dependent effect on the parameters studied in young adult rats.
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Gluck, Beth. "The Effects of Physical Activity on Bone Density in Adolescent Females". Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/GluckB2004.pdf.
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Yerramshetty, Janardhan Srinivas. "The Effect of Compositional and Physicochemical Heterogeneity on Age-Related Fragility of Human Cortical Bone". Connect to Online Resource-OhioLINK, 2006. http://www.ohiolink.edu/etd/view.cgi?acc_num=toledo1166237815.
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Trento, Cleverson Luciano [UNESP]. "Densitometria óssea em mandíbula de suínos submetidos a enxerto ósseo autógeno, homógeno e heterógeno". Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/102344.
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trento_cl_dr_araca.pdf: 759497 bytes, checksum: 21cd618f48eec3883664f80d6c2feab4 (MD5)Defeitos ósseos extensos na região maxilo-facial podem ser corrigidos com enxerto autógeno, no entanto, as desvantagens desta modalidade terapêutica têm levado a pesquisa por novos materiais para substituir esses enxertos. O objetivo deste estudo foi avaliar densitometricamente a incorporação dos enxertos autógeno, homógeno e heterógeno humano, sendo utilizado para isso dez suínos divididos em 4 grupos, com tempo de sacrifício de 7, 30, 60 e 90 dias. Os animais foram acompanhados clinicamente e a incorporação dos enxertos foi analisada densitometricamente através do aparelho DEXA da Lunar. Os resultados mostraram que o enxerto heterógeno humano apresentou menor reabsorção seguido pelo homógeno, que estatisticamente comprovou existirem diferenças significativas tanto entre os suínos em relação ao tempo de sacrifício quanto entre os tratamentos autógeno, homógeno e heterógeno humano, podendo-se concluir que estes podem ser utilizados como alternativa viável na substituição do osso de origem autógena.
Extensive bony defects in the maxilofacial area can be corrected with autogenous graft, however the disadvantages of this therapeutic modality have been taking to the research for new materials to substitute those grafts. This study aimed to evaluate densitometrically the incorporation of the autogenous, homogenous and heterogenous human bone graft. Ten swines divided in 4 groups, with time of sacrifice of 7, 30, 60 and 90 days. The animals were accompanied clinically and the incorporation of the grafts was analyzed densitometrically through the apparel DEXA of the Lunar. The results showed that the heterogenous human graft presented smaller reabsorption proceeded by the homogenous graft, that statistically proved to exist significant differences so much among the swines in relation to the time of sacrifice as it enters the autogenous, homogenous and heterogenous human treatments, could be concluded that these can used as viable alternative in the substitution of the autogenous bone.
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Lembo, Marcia. "Estudo comparativo da densidade mineral óssea (DMO) em gatos domésticos (felis catus) castrados e não castrados, por meio da técnica de densitometria óptica radiográfica". Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-05032007-160115/.
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Através da técnica de Densitometria Óptica Radiográfica consegue-se aferir o conteúdo mineral do osso com auxílio de imagens radiográficas, demonstrando ser uma metodologia precisa, confiável e de baixo custo. Procurou-se comparar os valores da densidade mineral óssea em gatos castrados precocemente - antes da puberdade - e gatos inteiros. O grupo experimental foi composto de 59 animais, separados em fêmeas e machos, castrados e inteiros. As densidades ópticas foram medidas por meio do programa de processamento de imagens ImageLab. Foram estudadas as correlações entre os valores de DMO, peso e sexo. Os gatos machos apresentaram valores de DMO e peso maiores que as fêmeas (P<0,001). Quando separados em machos castrados e inteiros e fêmeas castradas e inteiras, os gatos machos inteiros apresentaram maior valor de DMO, independentemente do peso. Entre as fêmeas não houve diferença significativa com os valores de DMO para os animais castrados e inteiros já os gatos machos castrados apresentaram valores de DMO semelhantes ao das fêmeas castradas demonstrando que com a castração precoce há uma diminuição da densidade mineral óssea. A correlação entre peso e a DMO se mostrou mais importante nos animais inteiros que nos castrados demonstrando que a interdependência entre peso e DMO varia com a ação hormonal. Os valores médios de DMO obtidos foram de 3,7±0,44mmAl para o grupo total de fêmeas, sendo de 3,69±0,56mmAl para as fêmeas castradas e 3,72±0,25mmAl para as fêmeas inteiras. Foram de 4,39±0,5mmAl Para o grupo total de machos, sendo de 4,52±0,38mmAl para ao machos inteiros e de 3,92±0,4mmAl para os machos castrados.Radiographic Optic Densitometry has proven itself to be a precise, reliable, and low-cost methodology that enables analysis of bone mineral content with the aid of radiographic images. A study was conducted in which the bone mineral density of cats sterilized in pre-pubescence was compared to that of non-sterilized cats. The experimental group was composed of 59 animals, which were then divided into male and female groups, as well as into sterilized and non-sterilized groups. The optic densities of these animals were measured by the image processing program software, ImageLab. The correlations between the values of BMD, weight and sex had been studied. The male cats had presented higher values of BMD and weight than female cats (P<0,001). When comparisons were made between spayed and non-spayed females and neutered and non-neutered males, the non-neutered male cats had presented higher value of BMD, independent of their weight value. As for the females, there were no significant differences in the values of BMD between spayed and non-spayed females. However, the neutered male cats presented similar values of BMD as spayed females. This illustrates that sterilization causes a reduction in bone mineral density. The correlation between weight and the BMD was more significant in the non-sterilized animal group than in the sterilized group, demonstrating that the interdependence between weight and BMD varies according to hormonal action. The average values of obtained BMD were 3,7±0,44mmAl for the whole female group, and more specifically, 3,69±0,56mmAl for spayed females and 3,72±0,25mmAl for the non-spayed females. As for the male group, the average BMD value for the whole group was 4,39±0,5mmAl. However, the average BMD value was 4,52±0,38mmAl for the non-castrated males and 3,92±0,4mmAl for the castrated males.
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Selim, Mariana Baroni. "Avaliação estrutural do osso terceiro metacarpiano equino frente à implantação de biopolímero à base de mamona". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/10/10137/tde-18072014-113131/.
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Uma série de novas estratégias vem sendo desenvolvidas com o objetivo de otimizar a reparação óssea, pois os métodos atualmente disponíveis em ortopedia humana e veterinária não apresentam resultados plenamente satisfatórios. Inúmeros pesquisadores dedicam-se ao desenvolvimento e estudo da compatibilidade de novos implantes com o propósito de acelerar a reparação óssea. O polímero a base de óleo de mamona tem chamado atenção para a sua aplicação como substituto ósseo, pois é um produto natural, biocompatível e com propriedades estruturais semelhantes às do tecido ósseo. Seis equinos foram submetidos à ostectomia na superfície diafisária dorsal de seus terceiros metacarpianos. Uma das falhas ósseas foi preenchida com o polímero a base de mamona e o outra, no membro contralateral permaneceu sem preenchimento, atuando como controle. Os animais foram acompanhados por um período de 120 dias após o procedimento através de monitoramento radiográfico da densidade óssea. Após este período, realizou-se biópsia para avaliação histológica por microscopias de luz e eletrônica de varredura. A densitometria óptica revelou valores médios de 14,17mmAl ± 1,722 e 16,33mmAl ±1,633 (p=0,027) para os grupos polímero e controle, respectivamente. A microscopia óptica de luz demonstrou maior porcentagem de tecido ósseo neoformado no grupo controle (50,15% ±14,83) quando comparado ao grupo polímero (26,94% ±12,06), com p0,0001. No entanto, a microscopia eletrônica de varredura permitiu observar que a qualidade do tecido ósseo formado na presença do biomaterial foi mantida. Além disso, não foram observadas reações adversas ao biomaterial, como a formação de tecido cicatricial ou reações de corpo estranho, levando a conclusão de que a poliuretana de óleo de mamona pode ser considerada adequada ao preenchimento de falhas ósseas em equinos, uma vez que desmonstrou compatibilidade e osteocondutividade.A series of new strategies have been developed in order to optimize bone repair, because the methods currently available for human and veterinary orthopedics have no fully satisfactory results. Many researchers have dedicated to develop and study the compatibility of new implants in order to accelerate bone repair. The polymer of castor oil have drawn attention for its application as a bone substitute because it is a natural, biocompatible and have structural properties similar to bone tissue. Six horses were submited to ostectomy on the dorsal surface of its third metacarpal bone. One of the bone defects was filled with polymer of castor oil and the other remained unfilled, as a control group. The animals were followed for a period of 120 days after the procedure by monitoring radiographic bone density. After this period, a biopsy was performed for histological evaluation by light and scanning electron microscopy. The optical densitometry revealed medium values of 14.17mmAl ± 1.722 and 16.33mmAl ± 1.633 (p = 0.027) for the polymer and control groups, respectively. The light microscopy showed a higher percentage of new bone formation in the control group ( 50.15% ± 14.83 ) than in the polymer group ( 26.94 % ± 12.06 ) , with p 0.0001. However, scanning electron microscopy allowed to observe that the quality of bone formation tissue in the presence of biomaterial was maintained. Furthermore, there were no adverse reactions to biomaterial, such as scar formation or as a foreign body reaction, allowing to conclude that the polymer of castor oil can be considered suitable to fill bone defects in horses, since it demonstrated compatibility and osteoconductivity.
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Cadarette, Suzanne M. "Development and validation of an osteoporosis risk assessment instrument (ORAI) to select women for bone densitometry". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0005/MQ45400.pdf.
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Oweis, Reem. "Associations between fluoride intakes, bone outcomes and dental fluorosis". Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6239.
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These PhD projects represent secondary analyses of data from the ongoing Iowa Fluoride Study (IFS)/Iowa Bone Development Study (IBDS). The aim of this dissertation was to explore the associations between period-specific and cumulative fluoride intakes from birth to age 17, and from birth to age 19 years and bone measures of participants. Also, this dissertation looked into the associations between the clinical presence of dental fluorosis and bone outcomes.
Participants have been participating in the IBDS that grew out of the IFS, which is a longitudinal investigation of dietary and non-dietary fluoride exposures, dental fluorosis and dental caries. IFS participants were recruited during 1992-95 from 8 hospital postpartum wards in Iowa, and detailed questionnaires were sent every 1.5-6 months. Data on intakes from water, other beverages, selected foods, dietary fluoride supplements and dentifrice were collected from the questionnaires, and, in combination with water and beverage fluoride levels, combined fluoride was estimated.
For the first dissertation project, the association between fluoride intake and peripheral quantitative computed tomography (pQCT)-derived bone outcomes at age 17 were assessed. Participants underwent pQCT of the radius and tibia (XCT-2000) at age 17 years. pQCT results of trabecular bone mineral density (BMD) and bone mineral content (BMC), cortical BMD and BMC, and compression and torsion strength were related to fluoride intake through bivariate and multivariable analyses, adjusting for height, weight, years since peak height velocity, average daily time spent in moderate-to-vigorous intensity physical activity, daily calcium intake, and daily protein intake. P-values < 0.01 were considered statistically significant rather than p< 0.05 due to multiple hypothesis tests. The mean daily fluoride intake estimated by area-under-the-curve (AUC) from birth to 17 years was 0.79 mg (SD = 0.32) for males and 0.70 mg (SD = 0.25) for females. Spearman correlation coefficients between daily fluoride intake and pQCT bone measures were weak (for females r= -0.01 to 0.15 for radius bone outcomes and -0.001 to 0.23 for tibia bone outcomes; for males r= 0.03 to 0.24 for radius bone outcomes and -0.008 to 0.27 for tibia bone outcomes). In sex-specific linear regression analyses for females, partially-adjusted for height, weight, and years since peak height velocity, statistically significant negative associations were detected between all radial bone outcomes and period-specific fluoride intake from 0-8.5 years. Significant positive associations were detected for females between period-specific fluoride intakes from 14-17 years and all tibia bone outcomes, and between period-specific fluoride intakes from 14-17 years and all radius and tibia bone outcomes for males. In the fully-adjusted models, which also included physical activity, protein intake and calcium intake, statistically suggestive negative associations were detected for females during the early fluoride intake period from 0 to 8.5 years and radial cortical bone content and torsion bone strength. A statistically suggestive positive association was found between period-specific fluoride intake from 8.5 to 14 years and torsion bone strength (pSSI) (p< 0.05) for females. For males, statistically significant positive associations were detected between fluoride intake for the period from 14 to 17 years and cortical content and torsion strength (pSSI) at the 0.01 level.
The second project examined the associations between period-specific and cumulative fluoride intakes from birth to age 19 years and MDCT-derived bone outcomes at age 19. Age 19 MDCT-derived trabecular and cortical bone micro-architecture scans were acquired at the University of Iowa Comprehensive Lung Imaging Center. MDCT results of the trabecular (volumetric bone mineral density (vBMD), transpose bone mineral density (tBMD), plate trabecula bone mineral density (pBMD), plate width (TS-PW), trabecular thickness (Tb.Th), trabecular spacing (Tb.Sp), trabecular network area (Tb.NA)) and cortical (cortical bone porosity (Cb.Poro), cortical thickness (Cb.Th)) bone were related to fluoride intake through bivariate and multivariable analyses, adjusting for height, weight, years since peak height velocity, average daily time spent in moderate-to-vigorous intensity physical activity, Healthy Eating Index (HEI) score, calcium intake and protein intake. P-values < 0.01 were considered statistically significant rather than p< 0.05 due to multiple hypothesis tests. The mean daily fluoride intake estimated by area-under-the-curve (AUC) from birth to 19 years was 0.81 mg (SD = 0.33) for males and 0.69 mg (SD = 0.27) for females. Spearman correlation coefficients between daily fluoride intake and MDCT bone measures were weak (for females r= -0.001 to 0.20 for trabecular bone outcomes and -0.01 to 0.02 for cortical bone outcomes; for males r= -0.003 to 0.16 for trabecular bone outcomes and -0.09 to -0.02 for cortical bone outcomes). In sex-specific partially-adjusted regression analysis adjusted for height, weight, and years since peak height velocity, no statistically significant associations were found for females or males. In the fully-adjusted models, which also included physical activity, HEI score, and protein and calcium intakes, no statistically significant associations were found for either females or males.
The third project explored the associations between dental fluorosis score at age 8 and DXA-derived bone outcomes at age 5. DXA bone assessments of the whole body, proximal femur (hip), and lumbar spine were performed at The University of Iowa in the Clinical Research Center (Hologic QDR-2000 DXA unit). The dental fluorosis score was defined as the proportion of zones with definitive or severe fluorosis per person. In the unadjusted associations between bone outcomes and dental fluorosis score, no statistically significant associations were detected for females at the 0.05 level. For males, a statistically significant negative association was found between hip BMD and dental fluorosis score. Sex-specific partial correlation coefficients were estimated between DXA-derived bone outcomes and dental fluorosis score adjusted for height, weight, physical activity, calcium intake and fluoride intake. No statistically significant associations were found for females. For males, a statistically significant negative association was detected between dental fluorosis score and hip BMD.
The findings of this dissertation show that life-long intakes from combined sources for adolescents and young adults living in fluoridated areas in the United States were weakly associated with bone measures at age 17 and 19. Furthermore, it was shown that bone outcomes can’t be predicted by the score of dental fluorosis.
Fluoride is a mineral that plays an important role in the mineralization of bone and teeth, as well as in dental caries prevention. Numerous professional health organizations endorse the adjusted fluoridation of public water supplies for caries prevention. Results from this dissertation will also help in supporting additional efforts to promote water fluoridation and expand its use, as this dissertation’s outcomes did not demonstrate adverse outcomes related to bone.
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Cheung, Ching-lung, i 張正龍. "Genetic linkage and association studies to identify candidate genes for bone mineral density variation in Southern Chinese". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B40203281.
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Li, Hoi-yee, i 李凱怡. "Identification of candidate genes for bone mineral density variation in Southern Chinese by integrating computational gene prioritization,linkage and association approaches". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45962200.
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Chivukula, Venu Sankar Murthy. "Dual energy X ray absorptiometry using digitised radiographs". Thesis, Queensland University of Technology, 2001.
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Ito, Kouta. "Use of the osteoporosis self-assessment tool : for referring older men for bone densitometry, a decision analysis /". Access full-text from WCMC :, 2008. http://proquest.umi.com/pqdweb?did=1527840081&sid=13&Fmt=2&clientId=8424&RQT=309&VName=PQD.
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Snook, Theresa J. "The utility of the Modifiable Activity Questionnaire for assessing the relationship between physical activity and bone density in children and adolescents". Electronic thesis, 2002. http://dspace.zsr.wfu.edu/jspui/handle/10339/222.
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Sun, Yurong. "Ultrasound characterization of structure and density of coral as a model for trabecular bone". Link to electronic version, 2000. http://www.wpi.edu/Pubs/ETD/Available/etd-0808100-001812/.
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Thesis (M.S.)--Worcester Polytechnic Institute.Keywords: angular decorrelation function; impulse response; BUA; BMD; ultrasound; coral; trabecular bone; osteoporosis. Includes bibliographical references (p. 189-191).
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Trento, Cleverson Luciano. "Densitometria óssea em mandíbula de suínos submetidos a enxerto ósseo autógeno, homógeno e heterógeno /". Araçatuba : [s.n.], 2006. http://hdl.handle.net/11449/102344.
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Orientador: Alvimar Lima de CastroBanca: Gilberto Aparecido Coclete
Banca: Pedro Ângelo Cintra
Banca: Édson Calixto da Fonseca
Banca: Ana Maria Pires Soubhia
Resumo: Defeitos ósseos extensos na região maxilo-facial podem ser corrigidos com enxerto autógeno, no entanto, as desvantagens desta modalidade terapêutica têm levado a pesquisa por novos materiais para substituir esses enxertos. O objetivo deste estudo foi avaliar densitometricamente a incorporação dos enxertos autógeno, homógeno e heterógeno humano, sendo utilizado para isso dez suínos divididos em 4 grupos, com tempo de sacrifício de 7, 30, 60 e 90 dias. Os animais foram acompanhados clinicamente e a incorporação dos enxertos foi analisada densitometricamente através do aparelho DEXA da Lunar. Os resultados mostraram que o enxerto heterógeno humano apresentou menor reabsorção seguido pelo homógeno, que estatisticamente comprovou existirem diferenças significativas tanto entre os suínos em relação ao tempo de sacrifício quanto entre os tratamentos autógeno, homógeno e heterógeno humano, podendo-se concluir que estes podem ser utilizados como alternativa viável na substituição do osso de origem autógena.
Abstract: Extensive bony defects in the maxilofacial area can be corrected with autogenous graft, however the disadvantages of this therapeutic modality have been taking to the research for new materials to substitute those grafts. This study aimed to evaluate densitometrically the incorporation of the autogenous, homogenous and heterogenous human bone graft. Ten swines divided in 4 groups, with time of sacrifice of 7, 30, 60 and 90 days. The animals were accompanied clinically and the incorporation of the grafts was analyzed densitometrically through the apparel DEXA of the Lunar. The results showed that the heterogenous human graft presented smaller reabsorption proceeded by the homogenous graft, that statistically proved to exist significant differences so much among the swines in relation to the time of sacrifice as it enters the autogenous, homogenous and heterogenous human treatments, could be concluded that these can used as viable alternative in the substitution of the autogenous bone.
Doutor
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Souza, Bruno Saturnino de [UNESP]. "Exercício resistido no tratamento e prevenção de osteopenia de ratos machos jovens". Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/132885.
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A estrutura óssea do ser humano bem como o processo de consolidação óssea são alvos de estudos constantes em todo o mundo. Fraturas e lesões são consequências da fragilidade óssea, normalmente causadas pela osteoporose, um grave problema de saúde pública. Estudos mostram que essa fragilidade pode ser atenuada pela atividade física regular e treinamento de força. O objetivo dessa pesquisa foi avaliar a eficácia do exercício físico resistido frente a osteopenia induzida em ratos que permaneceram com ausência de carga em seus membros pélvicos. O modelo foi o de suspensão da cauda em ratos. Estes foram distribuídos em quatro grupos: C, controle, com período experimental em gaiola; S, suspenso por 21 dias e colocados em solo por mais 21 dias; E, submetido a exercício em escada durante 21 dias e, depois, mantido em solo por mais 21 dias e SE, suspenso por 21 dias e depois submetido a exercício em escada durante 21 dias. Foram realizadas análise de densitometria óssea e ensaio mecânico na tíbia dos animais para avaliar a qualidade do tecido ósseo após o período experimental. Pelos resultados, foi possível observar que o exercício físico com carga e intensidade adequada resulta em aumento da rigidez, força máxima, densidade mineral óssea e conteúdo mineral ósseo caracterizando uma recuperação da qualidade do osso proporcionada pelo exercício físico. Desta forma, conclui-se que o exercício físico com carga resistida e intensidade adequada resulta em remodelação óssea positiva frente a suspenção pela cauda, que por sua vez induz a fragilidade óssea semelhante a osteopenia, sendo eficaz no tratamento e prevenção dessa enfermidade.
The bone structure of the human being and the bone healing process are constant targets of studies worldwide. Fractures and injuries are consequences of bone frailty, usually caused by osteoporosis, a serious public health problem. Studies have shown that regular physical activity and strength training can mitigate this weakness. The purpose of this study was to evaluate the effectiveness of the resistance exercise against osteopenia induced in rats that remained with no load on their hind limbs. The suspension model used was the rat’s tail model suspension. These rats were divided into four groups: C, control, with trial cage; S, suspended for 21 days and placed in soil for 21 days; E subjected to exercise ladder for 21 days and then kept in the soil for 21 days, and SE suspended for 21 days and then subjected to exercise ladder for 21 days. Bone densitometry analysis and mechanical testing in the tibia of the animals were realized to verify the quality of bone tissue after the trial period. It was possible to observe in the results that the exercise load and proper intensity results in increased rigidity, maximum strength, bone mineral density and bone mineral content featuring a recovery of bone quality provided by exercise. In this way, it was concluded that physical exercise with appropriate intensity and repeated load results in a positive bone remodeling before the suspension by the tail, which in turn induces a similar bone fragility osteoporosis, being effective in the treatment and prevention of this disease.
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Rodrigues, Beatriz Almeida. "Efeitos das antocianinas, ácidos hidroxinâmicos e vitamina C sobre a biometria, composição corporal e qualidade óssea de ratos Wistar /". Jaboticabal, 2016. http://hdl.handle.net/11449/137890.
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Orientador: Lizandra AmorosoCoorientador: Hugo Celso Dutra de Souza
Coorientador: Taís Harumi de Castro Sasahara
Banca: Fernanda Nogueira Valentin
Banca: Antônio Carlos Shimano
Resumo: A obesidade é um dos principais desafios para a saúde mundial e apresenta alta prevalência no homem e animais de companhia. Considerando a relevância dessa enfermidade, realizamos a presente pesquisa com o objetivo de avaliar o peso corporal, circunferência abdominal, índice de Lee, composição corporal, índice de Seedor, densidade mineral e resistência óssea de ratos Wistar tratados com dieta hipercalórica associada ou não à laranja vermelha, Citrus sinensis (L) Osbeck. O grupo que recebeu somente dieta hipercalórica apresentou menor massa magra em relação aos demais. Os animais tratados com fitoterápico associado à dieta hipercalórica apresentaram redução significativa na porcentagem de gordura em relação ao grupo tratado somente com dieta hipercalórica. Nos ensaios biomecânicos do úmero e fêmur não houve diferença na força máxima de ruptura, embora, no ensaio de compressão houve tendência de maior fragilidade óssea da cabeça do fêmur em ratos tratados somente com dieta hipercalórica. A associação de antocianinas, ácidos hidroxicinâmicos e vitamina C não interfere na densidade mineral óssea e na resistência biomecânica do úmero de ratos tratados com dieta padrão ou hipercalórica no período de cinco meses. Indivíduos resistentes à mudança de hábitos alimentares poderiam ser beneficiados pelo uso prolongado das antocianinas graças ao aumento da massa magra e redução da porcentagem de gordura após tratamento prolongado com laranja vermelha.
Abstract: Obesity is a major challenge to global health and is highly prevalent in humans and pets. Considering the importance of this disease, we carried out this research in order to evaluate body weight, waist circumference, Lee index, body composition, Seedor index, mineral density and bone strength of Wistar rats treated with high calorie diet with or without orange red, Citrus sinensis (L) Osbeck. We note that the animal that received only calorie diet showed less lean mass than the others. In addition, animals treated with herbal associated with calorie diet showed significant reduction in body fat percentage compared to the group treated only with high calorie diet. In biomechanical testing of the humerus and femur there was no difference in maximum breaking strength, although the compression test tended increased bone fragility of the femoral head in rats treated only with high calorie diet. The association anthocyanins, hydroxycinnamic acids and vitamin C does not interfere with bone mineral density and biomechanical strength of the humerus rats treated with standard hypercaloric diet during five months of treatment. Resistant individuals to changing eating habits could benefit by prolonged use of anthocyanins through increased lean mass and decreased body fat percentage after prolonged treatment with red orange.
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Rice, Jennifer Lynn Zonker. "The effects of acculturation, diet, and workload on bone density in premenopausal Mexican American women". Columbus, Ohio : Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1080330206.
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Thesis (Ph. D.)--Ohio State University, 2004.Title from first page of PDF file. Document formatted into pages; contains xvi, 172 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Paul W. Sciulli, Dept. of Anthropology. Includes bibliographical references (p. 143-154).
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Gomes, Adilson Mangela. "Prevalência de osteopenia e osteoporose e fatores de risco em adultos e idosos assistidos pelo Programa Médico de Família de Niterói: uma análise estratificada por gênero". Niterói, 2016. https://app.uff.br/riuff/handle/1/4614.
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OSS Viva Comunidade
O presente trabalho discute questões referentes à osteoporose e índice de massa corporal (IMC), considerados atualmente como importantes problemas de saúde pública do mundo, devido, sobretudo, ao processo de envelhecimento populacional e sua relação com a morbidade e a mortalidade. O tecido ósseo encontra-se em constante processo de remodelação. A homeostase do sistema está na dependência de uma remodelação óssea equilibrada, ou seja, da dinâmica balanceada entre a atividade dos osteoblastos e osteoclastos. Se este balanço inclinar-se a favor dos osteoclastos, levará à perda de massa óssea. Diferentes técnicas têm sido empregadas para o diagnóstico da osteoporose, sendo a densitometria óssea o melhor método disponível, devido à utilização de absorciometria de dupla energia de raios-X (DXA), permitindo medir partes centrais do esqueleto (coluna e fêmur). O objetivo desta pesquisa é estimar a prevalência da osteoporose na população adulta assistida na atenção básica de Niterói e sua associação com fatores de risco em uma análise estratificada por gênero. Para tanto, foi realizado um estudo observacional, transversal, com 366 pessoas de ambos os sexos, com idade ≥ 45 anos, residentes no município de Niterói, Brasil. Foram consideradas as seguintes variáveis: sexo, idade, cor da pele, consumo de álcool, prática de atividade física, IMC, uso de tiazídicos e relação cálcio/creatinina urinária. Com base nos dados, percebe-se que a prevalência de perda de massa óssea, em qualquer grau, foi de 52,1%, sendo 44,1% apresentando osteopenia e 7,9% osteoporose. Quanto ao efeito da massa corporal, o aumento do IMC parece conferir proteção para a perda de massa óssea que ocorre com o envelhecimento, sendo maior nas faixas etárias menores, em ambos os sexos. Curiosamente a excreção urinária de cálcio parece ser um fator de risco para o aumento da perda de densidade mineral óssea (DMO).
This work discuss issues concern of osteoporosis and body mass index (BMI), considered as important topics of global public health, due, about everything, to the populational ageing and its relationship with morbidity and mortality. The bone tissue is constantly remodeling process. The system’s homeostasis is on balanced bone reshuffle balance dependence, meaning, depends on balanced dynamics between osteoblasts and osteoclasts activite. If this balance tended to osteoclasts, it’ll take to bone mass loss. Different techniques have been employed for the diagnosis of osteoporosis, and bone densitometry the best available method, for use dual-energy x-ray absorptiometry (DXA), allowing measure central parts of the skeleton (spine and femur). The objective of this research is to estimate the prevalence of osteoporosis in assisted adult population in primary care Niterói and its association with risk factors in a stratified analysis by gender. For this, an observational and cross-sectional study with 366 people of both sexes aged less than or equal to 45 years, living in Niterói, Brazil. The following variables were considered: gender, age, skin color, alcohol consumption, physical activity, BMI, use of thiazides and calcium / urinary creatinine. Based on the data, it is clear that the prevalence of bone loss in any degree, was 52.1%, with 44.1% having osteopenia and osteoporosis 7.9%. As for the effect of body mass, increased BMI and waist circumference seems to confer protection to the loss of bone mass that occurs with aging, being higher in younger age groups, in both sexes. Interestingly, the urinary excretion of calcium appears to be a risk factor for the increased loss of bone mineral density (BMD).
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Ellis, Tiffany A. "Comparison of bone density in female vollyball players and age-matched non-athletes". Virtual Press, 2005. http://www.oregonpdf.org.
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Kleinschmidt, Ross. "An investigation of fluorometry techniques for in-vivo bone mineral determination". Thesis, Queensland University of Technology, 2001.
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Dissenha, Adrielly. "Uso do decanoato de nandrolona no tratamento da não união óssea em fraturas do rádio - estudo experimental em coelhos (oryctolagus cuniculus) /". Jaboticabal, 2019. http://hdl.handle.net/11449/190970.
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Orientador: Bruno Watanabe MintoResumo: O objetivo da pesquisa foi avaliar a eficácia do Decanoato de Nandrolona (DN) em fraturas do rádio após indução da não união óssea por defeito segmentar. Foram utilizados 47 coelhos, da raça Nova Zelândia Branco, com peso médio de 3,8 kg, divididos aleatoriamente em grupos de 8 animais. Os grupos Controle Machos (GCM) e Controle Fêmeas (GCF) foram submetidos à eutanásia aos 45 dias, os grupos Nandrolona Machos (GNM) e Nandrolona Fêmeas (GNF) tratados com aplicações semanais de DN na dose de 10mg/kg, via intramuscular (IM) durante 4 semanas. Os Grupos Placebo Machos (GPM) e Grupo Placebo Fêmeas (GPF), tratados com aplicações semanais de NaCl 0,9% (IM), durante o mesmo período. Foi realizado exame radiográfico após a cirurgia e aos 15, 30, 45, 60, 75 e 90 dias. Os animais dos grupos GNM, GNF, GPM e GPF foram submetidos à eutanásia aos 90 dias. Realizou-se exame de densitometria óssea do rádio dissecado após a eutanásia em todos os grupos, bem como análise histológica. Para as variáveis não-paramétricas utilizou-se o teste de Kruskal-Wallis. Para as variáveis paramétricas foi utilizado o teste Shapiro-Wilk, ambos a 5% de significância. Radiograficamente, os grupos tratados com DN apresentaram média de escore superior aos demais grupos na formação de calo ósseo. Na análise densitométrica, também foi observada uma melhora significativa ao parâmetro de composição mineral óssea (BMC) nos grupos GNM e GNF. Os machos apresentaram maiores médias para os parâmetros conteúdo mineral ósse... (Resumo completo, clicar acesso eletrônico abaixo)
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Kitamura, Karen Tieme. "Uso da radiografia panorâmica para identificação de baixa densidade óssea em pacientes com síndrome de Down". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/23/23141/tde-28052013-195327/.
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A síndrome de Down (SD) é a causa genética mais comum de comprometimento intelectual associada a doenças sistêmicas, como o envelhecimento precoce e alterações músculo-esqueléticas que aumentam o risco de osteoporose (OP). A OP é uma doença do esqueleto, caracterizada por baixa massa óssea e deterioração da micro arquitetura do tecido ósseo, com aumento de fragilidade óssea e susceptibilidade à fratura, considerada um problema de saúde mundial, que aumenta o risco de mortalidade e os custos médicos. Tem como fatores de risco para o desenvolvimento de OP: sexo feminino, raça branca ou asiática, história familiar, imobilidade, abuso de álcool, massa muscular, uso crônico de corticosteróides, a falta de terapia de reposição hormonal, tabagismo, sedentarismo e baixa ingestão de cálcio. Muitos destes fatores podem ser encontrados em indivíduos com SD, onde recentemente a OP foi identificada em adultos jovens. O diagnóstico precoce da OP impede fraturas e é extremamente importante, realizado pelo exame absormetria de dupla energia de raios X (DXA), ou seja, a densitometria óssea, que determina a densidade óssea (DO). Embora exames radiográficos não serem precisos para o diagnóstico da OP, se bem interpretados, eles podem ser ferramentas poderosas para o screeening da OP. A radiografia panorâmica é o exame radiográfico mais solicitado do corpo humano e muitas vezes é realizado como exame complementar no diagnóstico odontológico. Assim, os dentistas podem desempenhar um papel importante para o diagnóstico da OP e prevenção de fraturas osteoporóticas. O objetivo deste trabalho foi comparar a radiografia panorâmica (PAN) com a DXA para identificar a OP na SD. Foram avaliados 37 pacientes com SD do CAPE/FOUSP, com idade mínima de 25 anos, cujos pais ou responsáveis concordaram e assinaram o Consentimento Informado (CEP-FOUSP 79/2009). Foram colhidos os dados do histórico médico, realizado a PAN e a DXA do rádio e da ulna. Na radiografia panorâmica foram avaliados a medida da largura da cortical mandibular e o formato da cortical mandibular usando o software Radiocef Studio 2. Foram comparado os resultados da PAN com os resultados da DXA. Os resultados mostraram 21 pacientes do sexo masculino e 16 do sexo feminino, sendo 33 pacientes brancos, 03 negros e 01 amarelo. A idade variou de 25 a 60 anos e 01 mês, com média de 32 anos. As medidas da cortical mandibular dos pacientes com SD variou de 1,94 mm a 4,49 mm, com média de 3,01mm. Na avaliação do formato da cortical mandibular, 2 pacientes apresentaram formato C1 (cortical mandibular normal), 15 pacientes apresentaram formato C2 (cortical mandibular com ligeira erosão) e 20 pacientes apresentaram formato C3 (cortical mandibular severamente erodida), segundo a classificação de Klemeti et al., 1994. O trabalho realizado nos permitiu concluir que os indicadores anatômicos mensuráveis de radiografias panorâmicas digitais normalmente utilizados para identificação de baixa DO na população normorreativa não devem ser utilizados como parâmetros para a identificação de baixa densidade óssea em pacientes com SD; o screening da OP em pacientes com SD deve ser baseado na avaliação clínica e nas mudanças radiográficas, uma vez que as alterações das estruturas ósseas destes pacientes dificultam a correlação com valores pré-estabelecidos e ainda que faz-se necessário a elaboração de valores padrões de indicadores anatômicos mensuráveis exclusivos para identificação de baixa densidade óssea em pacientes com SD.Down Syndrome (DS) is the most common genetic cause of intellectual impairment associated with systemic disorders such as premature aging and muscle skeletal changes that increase the risk of osteoporosis (OP). The OP is an skeletal disease characterized by low bone mass and micro architectural deterioration of bone tissue, with increase of bone fragility and susceptibility to fracture, which is a global health problem, that increases the risk of mortality and medical costs. Risk factors for the development of OP are: female gender, white or asian race, family history, immobility, alcohol abuse, poor muscle mass, chronic corticosteroid use, lack of hormone replacement therapy, smoking, sedentary lifestyle and low calcium intake. Many of these factors can be found in individuals with DS, where recently the OP has been identified in young adults. Early diagnosis of OP prevents fractures and it is extremely important. It´s performed by the exam dual-energy X-ray absorptiometry (DXA), which determines the bone density (BD). However, these tests are not available for the Brazilian population in general. Although X-ray exams are not precise for the diagnosis of OP, they can provide powerful tools to screen potential patients with OP, since they are well interpreted. The panoramic radiograph (PAN) is the most requested x-ray of the human body and is often performed as a complementary test in dental diagnosis. Thus dental surgeons can play an important role for the diagnosis of OP and prevention of fractures. The aim of this study was compare PAN with dual-energy X-ray absorptiometry (DXA) to identify OP at DS. STUDY DESIGN: Patients with DS-CAPE/FOUSP, aged at least 25 years, who parents agreed and signed the Informed Consent (CEP-FOUSP 79/2009). The data from medical history was taken, it was performed PAN, and DXA of radius and ulna. The width and the shape of the mandibular cortical was evaluated at PAN using Radiocef Studio 2 software, and the results of PAN were compared with the result of DXA. CONCLUSIONS: The screening of OP in DS patients should be based on clinical evaluation and radiographic changes, since the changes of the bone structure of these patients are difficult to compare with values previously established.
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Rodrigues, Beatriz Almeida [UNESP]. "Efeitos das antocianinas, ácidos hidroxinâmicos e vitamina C sobre a biometria, composição corporal e qualidade óssea de ratos Wistar". Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/137890.
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A obesidade é um dos principais desafios para a saúde mundial e apresenta alta prevalência no homem e animais de companhia. Considerando a relevância dessa enfermidade, realizamos a presente pesquisa com o objetivo de avaliar o peso corporal, circunferência abdominal, índice de Lee, composição corporal, índice de Seedor, densidade mineral e resistência óssea de ratos Wistar tratados com dieta hipercalórica associada ou não à laranja vermelha, Citrus sinensis (L) Osbeck. O grupo que recebeu somente dieta hipercalórica apresentou menor massa magra em relação aos demais. Os animais tratados com fitoterápico associado à dieta hipercalórica apresentaram redução significativa na porcentagem de gordura em relação ao grupo tratado somente com dieta hipercalórica. Nos ensaios biomecânicos do úmero e fêmur não houve diferença na força máxima de ruptura, embora, no ensaio de compressão houve tendência de maior fragilidade óssea da cabeça do fêmur em ratos tratados somente com dieta hipercalórica. A associação de antocianinas, ácidos hidroxicinâmicos e vitamina C não interfere na densidade mineral óssea e na resistência biomecânica do úmero de ratos tratados com dieta padrão ou hipercalórica no período de cinco meses. Indivíduos resistentes à mudança de hábitos alimentares poderiam ser beneficiados pelo uso prolongado das antocianinas graças ao aumento da massa magra e redução da porcentagem de gordura após tratamento prolongado com laranja vermelha.
Obesity is a major challenge to global health and is highly prevalent in humans and pets. Considering the importance of this disease, we carried out this research in order to evaluate body weight, waist circumference, Lee index, body composition, Seedor index, mineral density and bone strength of Wistar rats treated with high calorie diet with or without orange red, Citrus sinensis (L) Osbeck. We note that the animal that received only calorie diet showed less lean mass than the others. In addition, animals treated with herbal associated with calorie diet showed significant reduction in body fat percentage compared to the group treated only with high calorie diet. In biomechanical testing of the humerus and femur there was no difference in maximum breaking strength, although the compression test tended increased bone fragility of the femoral head in rats treated only with high calorie diet. The association anthocyanins, hydroxycinnamic acids and vitamin C does not interfere with bone mineral density and biomechanical strength of the humerus rats treated with standard hypercaloric diet during five months of treatment. Resistant individuals to changing eating habits could benefit by prolonged use of anthocyanins through increased lean mass and decreased body fat percentage after prolonged treatment with red orange.
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Baer, Janine M. "Changes in bone density in calcium supplemented adolescent female athletes experiencing menstrual dysfunction". Diss., Virginia Polytechnic Institute and State University, 1988. http://hdl.handle.net/10919/49922.
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Scott, Chloe Elizabeth Henderson. "Effect of unicompartmental knee replacement tibial component design on proximal tibial strain and ongoing pain". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23397.
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Introduction: Unicompartmental knee replacements (UKRs) are an alternative to total knee replacements (TKRs) for treating isolated medial compartment knee osteoarthritis. However, revision rates are consistently higher than for TKR and UKRs are commonly revised for “unexplained” pain, a possible cause of which is elevated proximal tibial bone strain. The influence of implant design on this strain has not been previously investigated. Aims: The aims of this thesis are to determine the effect of medial UKR tibial component design on proximal tibial strain and ongoing pain. Methods: A retrospective clinical cohort study was performed comparing patient reported outcome and implant survival of a metal backed mobile bearing UKR implant (n=289) and an all-polyethylene (AP) fixed bearing UKR implant (n=111) with minimum 5 year follow up. A method of digital radiological densitometry, the greyscale ratio b (GSRb), was developed, validated and applied to plain radiographs to measure changes in bone density over 5 years in both the metal backed (n=173) and all-polyethylene (n=72) UKR patients. A finite element model (FEM) was validated against previous mechanical testing data and was used to analyse the effect of metal backing and implant thickness on proximal tibial cancellous bone strain in fixed bearing UKR implants. Results: There were no significant differences in patient reported outcomes between implants throughout follow up. Ten year all cause survival was 90.2 (95%CI 86-94) for the metal backed implant and 79.9 (60.7 to 99) for the all-polyethylene. Revision for unexplained pain was significantly greater in the AP implant where revisions were performed significantly earlier. Overall, the mean GSRb reduced following medial UKR with no difference between implants. In those patients where GSRb increased, patient reported outcomes were worse with an association with ongoing pain. A finite element model was successfully validated using acoustic emission and digital image correlation data. This model confirmed that the volume of cancellous bone exposed to compressive and tensile strains in excess of 3000 (pathological overloading) and 7000 (fracture) microstrain were higher in the AP implants, as were peak tensile and compressive strains. Varying polyethylene insert thickness did not affect these strain parameters in the metal backed implant, but varying polyethylene thickness in the AP implants had significant effects at all loads with elevated strains in thinner implants. Increasing the AP thickness to 10mm did not reduce strains to the levels found under metal backed implants, and imminent cancellous bone failure was implied when AP thickness was reduced to 6mm. Conclusion: UKRs with all-polyethylene tibial components are associated with greater proximal tibial strains than metal backed implants and this is exacerbated in thinner implants. The clinical consequences of this are uncertain. Medial UKR implantation does alter proximal tibial GSRb, though this is not uniform and is independent of implant type. When GSRb increases it is associated with ongoing pain.
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Silva, Claudia Cassimira da. "Efeito das fontes de zinco na dieta de matrizes suínas e na sua progênie". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-28012015-143551/.
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Diante da importância do zinco no desempenho produtivo e reprodutivo de matrizes suínas, e no desempenho de leitões, foram conduzidos três experimentos com o objetivo de avaliar diferentes fontes de zinco na alimentação de suínos. O experimento I avaliou diferentes fontes de zinco, orgânico (zinco+metionina ((Zn-Met) e zinco+glicina(Zn-Gli)) e inorgânico (óxido de zinco(ZnO)) na dieta de matrizes em gestação e lactação e os efeitos do uso destas fontes na sua progênie. Foram utilizadas 18 fêmeas de uma linhagem comercial distribuídas em delineamento experimental de blocos ao acaso, com três tratamentos e seis repetições de um animal. As características avaliadas nas matrizes foram: peso, espessura de toucinho, prolificidade, número de leitões nascidos vivos e níveis séricos de zinco no colostro e no leite. Para os leitões após parto até a desmama foram analisados: níveis de zinco no soro, ganho de peso, histomorfologia entérica e densidade óssea. No experimento II foram utilizados 180 leitões, desmamados com 21 dias de idade, distribuídos em delineamento de blocos ao acaso em esquema fatorial 3 x 3 (3 dietas maternas - 100 ppm de ZnO, Zn-Met, Zn-Gli x 3 dietas da progênie - 100 ppm de ZnO, Zn-Met, Zn-Gli) totalizando 9 tratamentos e 5 repetições de 4 animais cada, em que foram avaliados o desempenho, incidência de diarréia, níveis de zinco no soro, densidade óssea e histomorfologia entérica No experimento III foram utilizados 810 leitões, desmamados com 21 dias de idade, distribuídos em delineamento de blocos ao acaso com 6 tratamentos de 3 repetições de 45 animais: Fases I e II - 1. dieta + 2300 ppm de ZnO; 2. dieta + 2200 ppm de ZnO + 100 ppm de Zn-Met; 3. dieta + 2200 ppm de ZnO + 100 ppm de Zn-Gli; 4. dieta + 2400 ppm de ZnO; 5. dieta + 2200 ppm de ZnO + 200 ppm de Zn-Met; 6. dieta + 2200 ppm de ZnO+200 ppm de Zn-Gli; Fase III - 1. dieta + 1600 ppm de ZnO; 2. dieta + 1500 ppm de ZnO + 100 ppm de Zn-Met; 3. dieta + 1500 ppm de ZnO + 100 ppm de Zn-Gli; 4. dieta + 1700 ppm de ZnO; 5. dieta + 1500 ppm de ZnO + 200 ppm de Zn-Met; 6. dieta + 2200 ppm de ZnO+200 ppm de Zn-Gli, em que avaliou-se o desempenho dos animais. Os dados foram analisados utilizando o programa SAS (1998). As médias dos tratamentos foram comparadas pelo teste de Tukey ao nível de 5% de probabilidade, segundo Steel e Torrie (1980).Given the importance of zinc in the productive and reproductive performance of sows and piglets performance, three experiments to evaluate different sources of zinc in swine were conducted. The first experiment evaluated different sources of zinc, organic (zinc methionine (Zn-Met) and zinc glycine (Zn-Gly)) and inorganic (zinc oxide (ZnO)) in the diet of pregnant gilts and sows lactating and the effects of using these sources in their progeny. Were used 18 female of a commercial strain distributed in experimental design of randomized blocks with three treatments and six repetitions with one animal each. The characteristics evaluated in the sows were: weight, backfat thickness, prolificacy, number of piglets born alive and zinc levels in serum, colostrum and milk; In the piglets after birth until weaning were analyzed: serum levels of zinc, weight gain, bone density and histomorphology enteric. The second experiment 180 piglets were used, weaned at 21 days of age in a randomized block design in a factorial 3 x 3 (3 maternal diets - 100 ppm from ZnO , Zn-Met , Zn-Gly x 3 diets progeny - 100 ppm ZnO , Zn-Met - , Zn-Gly) totaling 9 treatments and 4 replicates of 5 animals each, which evaluated the performance, diarrhea incidence, serum zinc levels, bone density and histomorphology enteric. The third experiment 810 weaned pigs weaned at 21 days of age in a randomized block design with 6 treatments of 3 replicates of 45 animals each: Phases I and II - 1. diet + 2300 ppm of ZnO; 2. diet + 2200 ppm of ZnO + 100 ppm of Zn-Met; 3. diet + 2200 ppm ZnO + 100 ppm of Zn-Gly; 4. diet + 2400 ppm of ZnO; 5. diet + 2200 ppm of ZnO + 200 ppm of Zn- Met; 6. diet + 2200 ppm of ZnO + 200 ppm of Zn-Gly; Phase III - 1. diet + 1600 ppm of ZnO; 2. diet + 1500 ppm of ZnO + 100 ppm of Zn-Met; 3. diet + 1500 ppm of ZnO + 100 ppm of Zn-Gly; 4. diet + 1700 ppm of ZnO; 5. diet + 1500 ppm of ZnO + 200 ppm of Zn- Met; 6. diet + 2200 ppm of ZnO + 200 ppm of Zn-Gly in evaluating the performance of animals. All datas were analyzed using SAS (1998 ) program. The treatment means were compared by Tukey test at 5 % probability , according to Steel and Torrie (1980).