Rozprawy doktorskie na temat „Bone cells”
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Fong, Jenna. "Breast cancer cells affect bone cell differentiation and the bone microenvironment". Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104758.
Pełny tekst źródłaLe cancer du sein est le cancer plus diagnostiqué chez les femmes. On estime qu'environ une femme sur sept en sera affectée. La diffusion du cancer du sein aux emplacements secondaires est généralement incurable. L'os est l'emplacement préféré de la métastase, où le développement d'une tumeur secondaire cause de l'osteolyse, de l'hypercalcemie, et une douleur considérable. Cependant, comment les cellules de cancer du sein établissent des interactions supportifs avec des cellules d'os n'est pas bien compris. Nous avons examiné les effets des facteurs libérés des cellules du cancer du sein MDA-MB-231 et 4T1 sur la différentiation des cellules de moelle de la souris C57BL6. Le traitement avec des facteurs cancer-dérivés a produit une diminution de 40-60% des marqueurs de différentiation d'osteoblast, comparé au traitement par l'acide ascorbique, et a induit un changement osteoclastogenique dans le rapport du RANKL/osteoprotegerin. L'exposition des cellules d'os à des facteurs dérivés du cancer du sein a ensuite stimulé l'attachement des cellules cancéreuses aux osteoblasts non mûrs. L'inhibition du γ-secretase utilisant les inhibiteurs pharmacologiques DAPT et le Compound E a complètement inversé l'osteoclastogenise cancer-induit aussi bien que le perfectionnement cancer-induit de l'attachement de cellules cancéreuses, identifiant l'activité de le γ-secretase comme étant le médiateur principal de ces effets. Nous avons ensuite évalué les effets des cellules cancereuse sur le métabolisme énergétique des cellules d'os. Le traitement des cellules de moelle avec le medium conditionné des cellules du cancer du sein 4T1 a eu comme conséquence une augmentation des mitochondries à haut-potentiel de membrane, une augmentation de 2.3 fois le contenu cellulaire de triphosphate d'adénosine, et une consommation plus rapide du glucose. Ce changement de l'énergétique a été accompagné d'une stimulation d'AMPK dans la protéine et l'ADN messagère. Pour évaluer les effets du statut de haute énergie dans les osteoclasts, nous avons élevé l'énergique des osteoclasts avec du pyruvate de sodium. Cette addition a causée une croissance des osteoclasts, avec des plus grands nucleus, et la résorption de plus de substrat. Ainsi, nous avons découvert l'osteoblast comme étant un intermédiaire clé à la signalisation prémetastatique par des cellules du cancer du sein. Nous avons aussi indiqué le γ-secretase comme cible robuste pour le developpement de thérapeutique potentiellement capable de réduire l'autoguidage et la progression des métastases de cancer à l'os. Additonellement, nous avons découvert l'énergétique intensifiée chez les cellules d'os exposées aux facteurs cellule-libérés par le cancer du sein, qui mène à une osteoclastogenesise plus active et plus importante. La modification de la voie d'AMPK peut s'avérer être une cible thérapeutique importante pour que la métastase de cancer du sein aux os.
Hoebertz, Astrid. "Purinergic signalling in bone cells". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249706.
Pełny tekst źródłaLaketic-Ljubojevic, Ira. "Glutamate signalling in bone cells". Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311080.
Pełny tekst źródłaMalone, Amanda Michelle Dolphin. "Mechanotransduction mechanisms in bone cells /". May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Pełny tekst źródłaPorter, Ryan Michael. "Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration". Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/36365.
Pełny tekst źródłaMaster of Science
Bennett, Jonathan Hilary. "The differentiation of osteogenic cells from bone marrow". Thesis, University of Oxford, 1991. http://ora.ox.ac.uk/objects/uuid:3460f26e-a124-4605-8601-2e300241de14.
Pełny tekst źródłaGronthos, Stan. "Stromal precursor cells : purification and the development of bone tissue". Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phg8757.pdf.
Pełny tekst źródłaKandimalla, Yugandhar. "Study of Chitosan Microparticles with Bone Marrow Mesenchymal Stem Cells for Bone Tissue Regeneration". University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1250778129.
Pełny tekst źródłaWigzell, Cathy. "Differentiation of bone cells in vitro". Thesis, University of St Andrews, 1990. http://hdl.handle.net/10023/14070.
Pełny tekst źródłaWeber, Matthew Charles. "Engineering human bone marrow stromal cells". Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055867071.
Pełny tekst źródłaKe, Jin, i 柯金. "Transgenic stem cells for craniofacial bone reconstruction". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44362973.
Pełny tekst źródłapublished_or_final_version
Dentistry
Doctoral
Doctor of Philosophy
Lloyd, Brandon R. "Comparison of Bone Marrow Mesenchymal Stem Cells from Limb and Jaw Bones". The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1458678153.
Pełny tekst źródłaBoth, Sanne Karijn. "Embryonic stem cells in bone tissue engineering". Enschede : University of Twente [Host], 2008. http://doc.utwente.nl/58765.
Pełny tekst źródłaO'Shaughnessy, Margaret Clare. "Nitric oxide mediated effects on bone cells". Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367610.
Pełny tekst źródłaAmofah, Eunice. "Bone marrow stem cells in liver disease". Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497234.
Pełny tekst źródłaGu, Yuchun. "Investigation of ion channels on bone cells". Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369360.
Pełny tekst źródłaBirch, Mark Andrew. "Investigations of bone cells in Paget's disease". Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333632.
Pełny tekst źródłaRawlinson, Simon Charles Fielding. "Early loading-related responses of bone cells". Thesis, Royal Veterinary College (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313688.
Pełny tekst źródłaHall, Brett Matthew. "Effects of high dose chemotherapy on the bone marrow microenvironment". Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2558.
Pełny tekst źródłaTitle from document title page. Document formatted into pages; contains ix, 173 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 163-169).
Kwong, Rebecca Sze-Wai. "Interaction of bone marrow-derived mesenchymal stem cells on neuroblastoma cells". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48541485.
Pełny tekst źródłapublished_or_final_version
Paediatrics and Adolescent Medicine
Master
Master of Medical Sciences
Tsui, Yat-ping, i 徐軼冰. "Derivation of oligodendrocyte precursor cells from adult bone marrow stromal cells". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197485.
Pełny tekst źródłapublished_or_final_version
Biochemistry
Doctoral
Doctor of Philosophy
Raveney, Ben J. E. "Interactions between CD8+ T cells and bone marrow-derived dendritic cells". Thesis, University of Bristol, 2006. http://hdl.handle.net/1983/dbbc656f-a103-4787-aeb9-f203c3f0082b.
Pełny tekst źródłaBaba, Shinji. "Commitment of bone marrow cells to hepatic stellate cells in mouse". Kyoto University, 2005. http://hdl.handle.net/2433/144726.
Pełny tekst źródłaBhattacharjee, Atanu. "The potential of umbilical cord cells, autologous bone marrow stromal cells and autologous chondrocytes for bone and cartilage repair". Thesis, Keele University, 2018. http://eprints.keele.ac.uk/4592/.
Pełny tekst źródłaMauney, Joshua R. "Osteogenic differentiation of bone marrow stromal cells : implications to bone tissue engineering strategies /". Thesis, Connect to Dissertations & Theses @ Tufts University, 2004.
Znajdź pełny tekst źródłaAdviser: David L. Kaplan. Submitted to the Dept. of Biotechnology Engineering. Includes bibliographical references (leaves 162-222). Access restricted to members of the Tufts University community. Also available via the World Wide Web;
Adamek, Gaston. "Fatty acid oxidation in bone tissue and bone cells : characterization and hormonal influences /". [S.l : s.n.], 1987. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Pełny tekst źródłaSinghatanadgit, Weerachai. "Expression and regulation of bone morphogenetic protein receptors in human alveolar bone cells". Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445851/.
Pełny tekst źródłaAljazzar, Ahmed. "The role of osteocytes in the regulation of bone marrow mesenchymal stem cells". Thesis, Royal Veterinary College (University of London), 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701677.
Pełny tekst źródłaShah, Mittal. "The role of 5' adenosine monophosphate-activated protein kinase (AMPK) in bone physiology". Thesis, Royal Veterinary College (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559073.
Pełny tekst źródłaWang, Xiao Nong. "Quantitative analysis of alloreactive T cells in allogeneic stem cell transplantation". Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362419.
Pełny tekst źródłaLiu, Limin. "Expression of follicular dendritic cell determinants by mouse bone marrow stromal cells". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ37142.pdf.
Pełny tekst źródłaLiu, Limin 1954. "Expression of follicular dendritic cell determinants by mouse bone marrow stromal cells". Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27544.
Pełny tekst źródłaNyambo, Rachel Netsai. "Signalling interactions between human bone marrow stromal cells and prostate cancer cells". Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420799.
Pełny tekst źródłaTang, Hoi-ching, i 鄧鎧政. "The developmental origin of osteoblasts in endochondral bone". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4659940X.
Pełny tekst źródłaClutter, Suzanne Davis. "Chemotherapy disrupts bone marrow stromal cell function". Morgantown, W. Va. : [West Virginia University Libraries], 2006. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=4528.
Pełny tekst źródłaTitle from document title page. Document formatted into pages; contains x, 180 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
Zachos, Terri A. "Gene-augmented mesenchymal stem cells in bone repair". Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1146076285.
Pełny tekst źródłaIlvesaro, J. (Joanna). "Attachment, polarity and communication characteristics of bone cells". Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514259351.
Pełny tekst źródłaKapanen, A. (Anita). "Biocompatibility of orthopaedic implants on bone forming cells". Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514266064.
Pełny tekst źródłaRandle, Wesley Liam. "Tissue engineering of bone from embryonic stem cells". Thesis, Imperial College London, 2006. http://hdl.handle.net/10044/1/11880.
Pełny tekst źródłaAl-Khaldi, Abdulaziz A. "Therapeutic angiogenesis using autologous bone marrow stromal cells". Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32749.
Pełny tekst źródłaMethods and result. Using murine Matrigel angiogenesis model, we compared MSCs related angiogenesis to that produced by vascular endothelial growth factor (VEGF) and basic fibroblast growth factor. We found that MSCs result in an efficient and organized angiogenesis, arteriogenesis and vasculogenesis. MSC-related angiogenesis is VEGF dependent. MSCs in vivo produce VEGF that through paracrine effect induces local angiogenesis and through an autocrine loop stimulates FLK1+MSCs to differentiate into endothelial cells. MSCs implanted into ischemic hind limb resulted in marked improvement in blood flow and collateral vessels formation.
Conclusion. MSCs spontaneously induce efficient and mature angiogenesis in ischemic/hypoxic tissues with significant arteriolar component resulting in increased blood flow. They are also capable of spontaneous differentiation into endothelium. VEGF appears to be necessary for MSC-related angiogenesis and vasculogenesis.
Powell, Timothy Jack. "Characterisation of rat bone marrow derived dendritic cells". Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298613.
Pełny tekst źródłaGraves, Stephen Ellis. "Studies on human bone-derived cells in vitro". Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302849.
Pełny tekst źródłaEl-Gendy, Reem Omar Othman Mostafa. "Bone tissue engineering using dental pulp stem cells". Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.535682.
Pełny tekst źródłaRust, Philippa Ann. "Human mesenchymal stem cells for tissue engineering bone". Thesis, University College London (University of London), 2003. http://discovery.ucl.ac.uk/1383233/.
Pełny tekst źródłaMcDougall, Kathleen Emma. "Evaluation of biocompatibility using human craniofacial bone cells". Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368260.
Pełny tekst źródłaQualtrough, John David. "Bone morphogenetic proteins in human embryonal carcinoma cells". Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311810.
Pełny tekst źródłaMatthews, Natalie Anne. "Functional characterisation of Notch signalling in bone cells". Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442415.
Pełny tekst źródłaSpencer, Gary James. "Glutamate recycling and signalling mechanisms in bone cells". Thesis, University of York, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399248.
Pełny tekst źródłaMarcotti, Stefania. "Mechanical characterisation of bone cells and their glycocalyx". Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19596/.
Pełny tekst źródłaDavies, Julie Theresa. "Activation of adhesion of bone marrow stromal cells". Thesis, St George's, University of London, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.656858.
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