Gotowe bibliografie tematyczne / Biomolecules 2

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  2. Rozprawy doktorskie
  3. Książki
  4. Części książek
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Gotowa bibliografia na temat „Biomolecules 2”

Autor: Grafiati
Data publikacji: 6 września 2023

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Artykuły w czasopismach na temat "Biomolecules 2"

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Smith, Soshana, Katarina Goodge, Michael Delaney, Ariel Struzyk, Nicole Tansey i Margaret Frey. "A Comprehensive Review of the Covalent Immobilization of Biomolecules onto Electrospun Nanofibers". Nanomaterials 10, nr 11 (27.10.2020): 2142. http://dx.doi.org/10.3390/nano10112142.

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Biomolecule immobilization has attracted the attention of various fields such as fine chemistry and biomedicine for their use in several applications such as wastewater, immunosensors, biofuels, et cetera. The performance of immobilized biomolecules depends on the substrate and the immobilization method utilized. Electrospun nanofibers act as an excellent substrate for immobilization due to their large surface area to volume ratio and interconnectivity. While biomolecules can be immobilized using adsorption and encapsulation, covalent immobilization offers a way to permanently fix the material to the fiber surface resulting in high efficiency, good specificity, and excellent stability. This review aims to highlight the various covalent immobilization techniques being utilized and their benefits and drawbacks. These methods typically fall into two categories: (1) direct immobilization and (2) use of crosslinkers. Direct immobilization techniques are usually simple and utilize the strong electrophilic functional groups on the nanofiber. While crosslinkers are used as an intermediary between the nanofiber substrate and the biomolecule, with some crosslinkers being present in the final product and others simply facilitating the reactions. We aim to provide an explanation of each immobilization technique, biomolecules commonly paired with said technique and the benefit of immobilization over the free biomolecule.
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Tian, Yuan, i Karin Larsson. "Effect by Diamond Surface Modification on Biomolecular Adhesion". Materials 12, nr 6 (15.03.2019): 865. http://dx.doi.org/10.3390/ma12060865.

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Diamond, as material, show very attractive properties. They include superior electronic properties (when doped), chemical inertness, controllable surface termination, and biocompatibility. It is thus clear that surface termination is very important for those applications where the implant material is based on diamond. The present theoretical work has focused on the effect of diamond surface termination, in combination with type of surface plane, on the adhesion of important biomolecules for vascularization and bone regeneration. These biomolecules include Arginine-Glycine-Aspartic acid (RGD), Chitosan, Heparin, Bone Morphogenetic Protein 2 (BMP2), Angiopoietin 1 (AGP1), Fibronectin and Vascular Endothelial Growth Factor (VEGF). The various surface planes are diamond diamond (100)-2x1 and (111). The theoretical results show that the non-covalent binding of these biomolecules is in proportion with their molecular weights. Moreover, three groups of biomolecules were observed for both types of surface planes. The most strongly binding biomolecule was the BMP2 molecule. The smaller polypeptides (RGD, Chitosan and Heparin) formed a less strongly binding group. Finally, the biomolecules VEGF, Fibronectin and Angiopoietin showed bond strengths numerically in between the other two groups (thereby forming a third group). Moreover, the (111) surface was generally observed to display a stronger bonding of the biomolecules, as compared with the (100)-2x1 surface.
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Chuang, Yun-Ju, Mei-Jung Chen i Pei-Ru Chen. "Fabrication and Permeability Characteristics of Microdialysis Probe Using Chitosan Nanoporous Membrane". Journal of Nanomaterials 2014 (2014): 1–11. http://dx.doi.org/10.1155/2014/968098.

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In this article, a nanoporous chitosan polymer membrane was successfully produced and applied as microdialysis membrane forin vitrosampling of biomolecules. With the use of nanoparticle leaching technique, porogenic gelatin nanoparticles formed nanopores in the chitosan-based membrane to create a secure implantable nanoporous membrane for biomolecule sampling. The gelatin nanoparticles size was in the range of 45 to 70 nm, and the pore size of the chitosan membrane was around 40 to 100 nm. The porosity of membrane was found to be dependent on the mixing ratio of chitosan solution and gelatin nanoparticles solution. The results of diffusion study showed that we can alter the mixing ratio of porogen to achieve size-selective molecular diffusion, which means that the porosity and cut-off size of porous membrane can be controlled. The recoveries of the probe fabricated from the chitosan-based membrane were examined for four different model compounds of different molecular weights: 2-NBDG, substance P, TNF-α, and FITC-BSA. The microdialysis probes showed linear responses and substantial recovery to various concentrations of biomolecules. These results indicated that the microdialysis probe constructed by chitosan nanoporous membrane could sample and monitor the biomoleculesin vitroand has the potential for the applicationin vivo.
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Bao, Gang. "Mechanics of biomolecules". Journal of the Mechanics and Physics of Solids 50, nr 11 (listopad 2002): 2237–74. http://dx.doi.org/10.1016/s0022-5096(02)00035-2.

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Einarsson, Roland, Ingvar Sjöholm i Jörgen Vessman. "Biomolecules — analytical options". TrAC Trends in Analytical Chemistry 7, nr 9 (październik 1988): 315–17. http://dx.doi.org/10.1016/0165-9936(88)90019-2.

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ZHAO, PEIJI, DWIGHT WOOLARD, JORGE M. SEMINARIO i ROBERT TREW. "TOWARDS SENSING SINGLE OR A FEW BIO-MOLECULAR ARCHITECTURES: DESIGN OF FUNCTIONAL SURFACES". International Journal of High Speed Electronics and Systems 18, nr 01 (marzec 2008): 187–94. http://dx.doi.org/10.1142/s0129156408005266.

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There is considerable interest in electrical sensing of biomolecular binding since it has the potential to be label free, to work easily in aqueous environments native to the biomolecules, and to be integrated with small, fast, and inexpensive microelectronoics as detection instrumentation. Although electrochemical methods have been used successfully in detections of DNA molecules with Ag labels at very high sensitivity (~ p ml), detection of DNA molecules in terms of label free techniques has a lower sensitivity (~ μ ml). Here, the surface attachment chemistry is critical towards the detection of ultra-low concentration of biomolecules. In this article, based on density functional theory, we have calculated and analyzed the electrical characteristics of the contact between aromatic molecules and silicon (100) − 2×1 surfaces. Design principles for silicon based electrodes of electrochemically biomolecular sensing instruments for label-free sensing of single or a few biomolecular molecules have also been discussed.
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Muniyappan, Srinivasan, Yuxi Lin, Young-Ho Lee i Jin Hae Kim. "17O NMR Spectroscopy: A Novel Probe for Characterizing Protein Structure and Folding". Biology 10, nr 6 (21.05.2021): 453. http://dx.doi.org/10.3390/biology10060453.

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Oxygen is a key atom that maintains biomolecular structures, regulates various physiological processes, and mediates various biomolecular interactions. Oxygen-17 (17O), therefore, has been proposed as a useful probe that can provide detailed information about various physicochemical features of proteins. This is attributed to the facts that (1) 17O is an active isotope for nuclear magnetic resonance (NMR) spectroscopic approaches; (2) NMR spectroscopy is one of the most suitable tools for characterizing the structural and dynamical features of biomolecules under native-like conditions; and (3) oxygen atoms are frequently involved in essential hydrogen bonds for the structural and functional integrity of proteins or related biomolecules. Although 17O NMR spectroscopic investigations of biomolecules have been considerably hampered due to low natural abundance and the quadruple characteristics of the 17O nucleus, recent theoretical and technical developments have revolutionized this methodology to be optimally poised as a unique and widely applicable tool for determining protein structure and dynamics. In this review, we recapitulate recent developments in 17O NMR spectroscopy to characterize protein structure and folding. In addition, we discuss the highly promising advantages of this methodology over other techniques and explain why further technical and experimental advancements are highly desired.
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Yadav, R. A., P. N. S. Yadav i J. S. Yadav. "Vibrational studies of biomolecules. I. 2-Thiouracil". Proceedings / Indian Academy of Sciences 100, nr 1 (luty 1988): 69–78. http://dx.doi.org/10.1007/bf02839530.

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Yadav, R. A., P. N. S. Yadav i J. S. Yadav. "Vibrational studies of biomolecules—II. 2-thiocytosine". Spectrochimica Acta Part A: Molecular Spectroscopy 44, nr 11 (styczeń 1988): 1201–6. http://dx.doi.org/10.1016/0584-8539(88)80093-x.

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Miyagi, Masaru, i Takhar Kasumov. "Monitoring the synthesis of biomolecules using mass spectrometry". Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, nr 2079 (28.10.2016): 20150378. http://dx.doi.org/10.1098/rsta.2015.0378.

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The controlled and selective synthesis/clearance of biomolecules is critical for most cellular processes. In most high-throughput ‘omics’ studies, we measure the static quantities of only one class of biomolecules (e.g. DNA, mRNA, proteins or metabolites). It is, however, important to recognize that biological systems are highly dynamic in which biomolecules are continuously renewed and different classes of biomolecules interact and affect each other's production/clearance. Therefore, it is necessary to measure the turnover of diverse classes of biomolecules to understand the dynamic nature of biological systems. Herein, we explain why the kinetic analysis of a diverse range of biomolecules is important and how such an analysis can be done. We argue that heavy water ( 2 H 2 O) could be a universal tracer for monitoring the synthesis of biomolecules on a global scale. This article is part of the themed issue ‘Quantitative mass spectrometry’.
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Rozprawy doktorskie na temat "Biomolecules 2"

1

Tyler, Simon Nicholas George. "Asymmetric synthesis using enantiopure dihydro-2H-1,4-oxazin-2-one templates". Thesis, University of Reading, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266800.

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McConnell, Matthew S. "Nickel catalyzed formation of 1,2-cis-2-amino sugars to access important biomolecules". Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1881.

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The stereoselective formation of 1,2-cis-2-amino glycosides remains a challenging obstacle for researchers seeking to study glycan function in nature. A variety of techniques to form α-linked C(2)-aminoglycosides are examined herein. The most prominent of these techniques is the nickel catalyzed stereoselective coupling of C(2)-N-benzylidine protected trichloroacetimidates to form 1,2-cis-2-amino sugars. This protocol demonstrates excellent α-selectivity and is applicable to a large structural variety of C(2)-aminoglycosyl donors and acceptors. The application of the nickel catalyzed stereoselective coupling of C(2)-N-benzylidine protected trichloroacetimidates toward the synthesis of pseudosaccharides of glycosylphosphatidyl inositol (GPI) anchors and mycothiol (MSH) in good yield and with excellent α-selectivity was also examined. In stark contrast, employing conventional Lewis acids to activate trichloroacetimidate donors provided the desired pseudodisaccharides with poor α-selectivity. Additionally, the facile synthesis of both C(1)- and C(6)-hydroxyl myo-inositols bearing differentiated protecting groups from a common and easily attainable intermediate allows access to a wide variety of GPI anchor and MSH pseudosaccharides. The highly α-selective and scalable synthesis of the Fmoc-protected GalNAc-threonine amino acid and TN antigen in large quantities is also described. The challenging 1,2-cis-2-amino glycosidic bond is addressed through a coupling of threonine residues with C(2)-N-ortho-(trifluoromethyl)benzylidenamino trihaloacetimidates mediated by Ni(4-F-PhCN)4(OTf)2. The desired 1,2-cis-2-amino glycoside was obtained in large quantities with α-only selectivity and subsequently transformed into the Fmoc-protected GalNAc-threonine and TN antigen. With the establishment of 1,2-cis-selective synthesis of heparan disaccharides, we sought to develop multivalent inhibitors of heparanase. A model study of protein/glycan interactions, in which various macromolecular architectures were examined, was developed using Concanavalin A as the model protein. Preparations of the highly-ordered monoantennary, homofunctional diantennary, and heterofunctional diantennary glycopolymers of α-mannose and beta-glucose were achieved via ring opening metathesis polymerization. Isothermal titration calorimetry measurements of these synthetic glycopolymers with Concanavalin A, which has been reported to bind strongly to α-mannose unit, revealed that heterofunctional diantennary architectures bearing both α-mannose and non-binding beta-glucose residues, glucose units, enhanced binding affinity.
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Hughes, Juanita Maree. "A novel identification method for ultra trace detection of biomolecules using functionalised Surface Enhanced Raman Spectroscopy (SERS)". Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/72864/2/Juanita_Hughes_Thesis.pdf.

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This thesis developed a new method for measuring extremely low amounts of organic and biological molecules, using Surface enhanced Raman Spectroscopy. This method has many potential applications, e.g. medical diagnosis, public health, food provenance, antidoping, forensics and homeland security. The method development used caffeine as the small molecule example, and erythropoietin (EPO) as the large molecule. This method is much more sensitive and specific than currently used methods; rapid, simple and cost effective. The method can be used to detect target molecules in beverages and biological fluids without the usual preparation steps.
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Li, Aixiao. "Molecular modeling of non-bonding interactions in biomolecules-ligand systems". Paris 7, 2009. http://www.theses.fr/2009PA077032.

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Ce travail est consacré à la modélisation des interactions entre des inhibiteurs et des molécules impliquées dans la cancérisation, dans le but notamment d'établir de manière précise les modes d'interaction biomolécules-ligand. Dans la famille des CDK (cyclin dépendant kinases) nous nous sommes intéressés à la sélectivité que présente un nouvel inhibiteur (2PU) vis-à-vis de CDK4 par rapport à CDK2. Les méthodes employées : dynamique moléculaire, calculs d'énergies d'interaction, docking et méthodes mixtes du type ONIOM ont permis d'établir les raisons précises de la sélectivité en mettant en évidence des interactions privilégiées (notamment des liaisons H) entre l'inhibiteur et CDK4. Sur le plan méthodologique la méthode ONIOM (à deux ou trois couches) a fait l'objet d'une étude minutieuse et originale quant à la procédure de définition de la partition du système. Une nouvelle approche est proposée. La stabilisation du DNA G-quadruplex par un nouveau ligand (TQMP) a également été étudiée par dynamique moléculaire, ce qui a permis de préciser les modes d'interaction et de démontrer la sélectivité de l'un des deux sites possibles d'interaction
This work is devoted to modelling the interactions between some inhibitors and molecules involved in cancer development and aims at precisely establishing the interactions modes between the ligands and the biomolecules. In the CDK (cyclin dependant kinases) family we have examined the selectivity of a new inhibitor (2PU) towards CDK4 as compared to CDK2. The techniques we have used : molecular dynamics interaction energies calculation, molecular docking and mixed methods of the ONIOM type allowed us to establish the precise causes of this selectivity, showing the existence of specific interactions (H bonds, among others) between the inhibitor and CDK4. From a methodological point of view, the ONIOM method (with 2 or 3 layers) has been carefully examined with respect to the System partitioning procedure. A new approach is proposed. The stabilisation of G-quadruplex DNA by a new ligand (TQMP) has also been studied with molecular dynamics, which allowed establishing the interaction modes and show the selectivity of one of the 2 possible interaction sites
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Zhang, Xiaochun. "Design and characterization of biomolecule/semiconductor interfaces". Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 221 p, 2009. http://proquest.umi.com/pqdweb?did=1833646481&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Perazzolo, Chiara. "Internal motions in biomolecules studied by NMR spectroscopy : an application to major urinary protein-1 and its complex with 2-methoxy-3-isobutylpyrazine /". [S.l.] : [s.n.], 2006. http://library.epfl.ch/theses/?nr=3489.

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Brandani, Giovanni Bruno. "Molecular dynamics simulations of protein adsorption at interfaces". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20415.

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Proteins can often adsorb irreversibly at fluid/fluid interfaces; the understanding of the adsorption mechanism has relevance across a variety of industrial (e.g. the creation of stable emulsions) and biological (e.g. biofilm formation) processes. I performed molecular dynamics simulations of two surfactant proteins as they interact with air/water and oil/water interfaces, describing the origin of the surface activity, the adsorption dynamics and the conformational changes that these proteins undergo at the interface. BslA is an amphiphilic protein that forms a highly hydrophobic coat around B. subtilis biofilms, shielding the bacterial community from an external aqueous solution. By investigating the behaviour of BslA variants at oil/water interfaces via coarse-grained molecular dynamics, I show that BslA represents a biological example of an ellipsoidal Janus nanoparticle, whose surface interactions are controlled by a local conformational change. All-atom molecular dynamics simulations then reveal the details of the conformational change of the protein upon adsorption, and the self-assembly into a two-dimensional interfacial crystal. Ranaspumin-2 is one of the main components of the tungara frog foam nest. Contrary to most surfactant proteins, its structure lacks any sign of amphiphilicity. All-atom simulations show that the adsorption proceeds via a two-step mechanism where firstly the protein binds to the interface through its flexible N-terminal tail and then it undergoes a large conformational change in which the hydrophobic core becomes exposed to the oil phase. I then developed a simple structure-based coarse-grained model that highlights the same adsorption mechanism observed in all-atom simulations, and I used it to compare the dynamics of adsorption and the underlying free energy landscape of several mutants. These results agree with and are used to rationalise the observations from Langmuir trough and pendant drop experiments. Colloids can often be considered simpler versions of proteins that lack conformational changes. I performed coarse-grained simulations of the compression of interfacial monolayers formed by rod-like particles. These simulations show a rich behaviour characterised by the flipping of adsorbed rods, nematic ordering and bilayer formation. I report the series of transitions that take place as the rod aspect ratio is increased from 3 to 15.
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Araiz, Caroline. "Rôle des protéines 14-3-3 dans la régulation de la longévité par la voie DAF-2/Insuline/IGF-1 chez Caenorhabditis elegans". Phd thesis, Université Montpellier II - Sciences et Techniques du Languedoc, 2008. http://tel.archives-ouvertes.fr/tel-00347920.

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Les protéines 14-3-3 sont des protéines ubiquitaires conservées chez tous les eucaryotes. Elles interagissent avec de multiples partenaires, dont elles modulent la fonction et la localisation, et interviennent de ce fait dans de nombreux processus cellulaires. FTT-1 et FTT-2 sont les deux orthologues de 14-3-3 présents chez Caenorhabditis elegans. En utilisant l'approche de RNA interférence, nous avons montré que les protéines FTT sont impliquées dans la voie DAF-2/Insuline/IGF-1, régissant la longévité, la résistance au stress et le métabolisme chez C. elegans, et dont l'effecteur majeur est le facteur de transcription DAF-16, orthologue de Forkhead chez les mammifères. Ce travail de thèse a permis de caractériser les fonctions de chacune des protéines FTT dans la régulation des différents phénotypes engendrés par cette voie et de mettre en évidence le rôle prépondérant de FTT-2. D'autre part, nos données ont révélé la contribution supplémentaire de FTT-2 dans la régulation de la longévité et du métabolisme lipidique et de FTT-1 et FTT-2 dans la résistance au stress, à travers un mécanisme parallèle à la voie DAF-2/Ins/IGF-1 et ne mettant pas en jeu DAF-16. Les résultats de notre étude soulignent la complexité des fonctions des protéines FTT et démontrent leur participation à plusieurs processus importants pour la survie de C. elegans lors d'une exposition à un stress mais aussi lors du vieillissement physiologique du nématode.
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Vejux, Anne. "Caractérisation des figures myéliniques associées à l'accumulation de lipides polaires induites par différents oxystérols cytotoxiques identifiés dans les lésions athéromateuses : étude des relations entre apoptose et métabolisme des lipides". Phd thesis, Université de Bourgogne, 2006. http://tel.archives-ouvertes.fr/tel-00168283.

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L'athérosclérose est une pathologie artérielle complexe à évolution lente définie par un remodelage de la paroi vasculaire, associée à des réactions inflammatoires, à des processus de prolifération, de mort cellulaire et à une accumulation de lipides oxydés tels que les oxystérols (dérivés oxydés du cholestérol) dont le rôle est fortement suspecté dans le développement de l'athérome.

Le travail réalisé a été effectué sur des cellules monocytaires humaines U937 et THP-1, aortiques de rat A7R5 et carcinomateuses humaines MCF-7 (déficientes en caspase-3). Différents oxystérols, présents en quantité importante dans les lésions athéromateuses, ont été utilisés (7-cétocholestérol (7KC), 7Β-hydroxycholestérol, 25-hydroxycholestérol, cholestérol-5Α, 6Α-epoxide, cholestérol-5Β, 6Β-epoxide) ainsi que du cholestérol.

La première partie du travail a montré que la mort cellulaire induite par le 7KC est un phénomène complexe présentant des caractéristiques apoptotiques accompagnées d'une synthèse de structures multilamellaires cytoplasmiques appelées corps myéliniques visualisés par microscopie électronique à transmission. La synthèse rapide de ces structures précède les effets cytotoxiques : chute du potentiel membranaire mitochondrial, augmentation de la perméabilité à l'iodure de propidium et modifications de la morphologie nucléaire (condensation, fragmentation, gonflement des noyaux). L'isolement de ces structures par ultracentrifugation après coloration à la monodansylcadavérine (fluorochrome lysosomotropique acide) ou au Nile Red (fluorescence jaune en présence de lipides neutres et rouge en présence de lipides polaires) a permis de montrer qu'elles sont riches en lipides polaires (sphingomyéline, phosphatidylcholine) et en cholestérol et qu'elles accumulent le 7KC. Au sein de ces corps myéliniques, une co-localisation du 7KC avec les lipides polaires a été démontrée par la technique de FRET réalisée par microscopie confocale mono- et bi-photonique. Les caractéristiques morphologiques et biochimiques des figures myéliniques ont permis d'établir que le 7-cétocholestérol est un puissant inducteur de phospholipidose.

Compte tenu des modifications lipidiques spatiotemporelles, quantitatives et qualitatives, induites par le 7KC et révélé par le Nile Red, la seconde partie du travail a précisé les relations entre la mort cellulaire, la synthèse de corps myéliniques, l'accumulation de lipides polaires et l'activité caspase. Avec les différents oxystérols étudiés, les corps myéliniques ne sont observés qu'avec des composés cytotoxiques (7KC, 7Β-hydroxycholestérol, cholestérol-5Β, 6Β-epoxide) et leur synthèse est indépendante d'activité caspase. En revanche, l'accumulation de lipides polaires induite par le 7KC est inhibée en présence de z-VAD-fmk (inhibiteurs de caspases large spectre) et de z-VDVAD-fmk (inhibiteur de caspase-2). Certaines caspases et en particulier la caspase-2 pourraient contribuer à l'accumulation de lipides polaires.

La troisième partie du travail a conduit à étudier les effets de la Vitamine-E (VitE) sur la mort cellulaire induite par le 7KC en raison de ses propriétés anti-apoptotiques et anti-oxydantes. La VitE protège de la mort cellulaire induite par le 7KC. Les effets protecteurs pourraient en partie être dus à la capacité de la VitE à maintenir fonctionnelle la voie PI3-K/c-Akt en s'opposant aux déphosphorylations de PDK-1 et de c-Akt, et en préservant l'activité PI3-K. Par ailleurs, la VitE s'oppose aux modifications lipidiques au niveau de la membrane cytoplasmique et à l'accumulation de lipides polaires. La VitE réduit aussi la dégradation de la pro-forme de la caspase-2L et augmente les taux d'ARNm correspondants.

Ces travaux montrent des relations entre la mort cellulaire induite par des oxystérols et le métabolisme des lipides. Ils révèlent aussi que la VitE protège de la mort induite par le 7KC en agissant au niveau de la voie PI3-K/c-Akt. Par ailleurs, la VitE s'oppose aux modifications lipidiques membranaires et cytoplasmiques associées à la mort cellulaire induite par le 7KC.
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Galian, Barrueco Carmen. "Caractérisation de 2 transporteurs ABC (“ATP-Binding Cassette”) bactériens de fonction inconnue : YheI/YheH de Bacillus subtilis et Rv1747 de Mycobacterium tuberculosis". Phd thesis, Grenoble 1, 2008. http://tel.archives-ouvertes.fr/tel-00369447.

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L'émergence du phénotype MDR (« multidrug resistance») des cellules cancéreuses est souvent corrélée à la surexpression de protéines membranaires appartenant à la superfamille ABC (« ATP binding cassette »). Ces protéines couplent l'hydrolyse de l'ATP au transport d'agents chimiothérapeutiques vers l'extérieur des cellules. Chez les bactéries, des transporteurs homologues ont été impliqués dans certains cas de résistance aux antibiotiques.
Deux nouveaux transporteurs ABC bactériens, Rv1747 de Mycobacterium tuberculosis et YheI/YheH de Bacillus subtilis, potentiellement impliqués dans la résistance aux antibiotiques, ont été étudiés ici en réalisant une expression hétérologue chez Escherichia coli et en isolant des vésicules de membrane inversées. Ce système s'est avéré inapproprié pour l'étude du transporteur Rv1747, à cause vraisemblablement des différences entre E. coli et M. tuberculosis dans l'usage des codons. En revanche, nous avons obtenu un degré important de surexpression de YheI/YheH qui nous a permis de caractériser son activité de transport et d'hydrolyse de l'ATP. Nous avons ainsi montré que les deux protéines, YheI et YheH, s'associent pour former un exportateur hétérodimérique capable de transporter de multiples drogues, et que le rôle des deux sous-unités n'est pas identique dans le mécanisme catalytique du transporteur. Enfin, nous avons réussi à purifier le transporteur YheI/YheH avec un rendement élevé et dans un état fonctionnel stable, permettant d'approfondir sa caractérisation biochimique ainsi que d'obtenir des cristaux bidimensionnels pour une étude structurale par microscopie électronique.
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Książki na temat "Biomolecules 2"

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Linke, Wolfgang A., Henk Granzier i Miklós S. Z. Kellermayer, red. Mechanics of Elastic Biomolecules. Dordrecht: Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-010-0147-2.

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Canuto, Sylvio, red. Solvation Effects on Molecules and Biomolecules. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-8270-2.

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Japan. Kagaku Gijutsuchō. Kenkyū Kaihatsukyoku. Seitai no bunshi reberu ni okeru kōkando, kōbunkainō hi hakai keisoku gijutsu no kaihatsu ni kansuru kenkyū (dai I-ki, Shōwa 63--Heisei 2-nendo) seika hōkokusho. [Tokyo]: Kagaku Gijutsuchō Kenkyū Kaihatsukyoku, 1992.

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Patra, Abhijeet. Quantifying Interactions of Biomolecules with Inorganic Surfaces. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-30728-2.

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International Symposium on Separations for Biotechnology (2nd 1990 University of Reading). Separations for biotechnology 2: Papers presented at the Second International Symposium on Separations for Biotechnology, held at the University of Reading, UK, 10-13 September 1990. London: Published for SCI by Elsevier, 1990.

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International Symposium on Form and Function in Zoology (1989 Bormio, Italy). Form and function in zoology: Proceedings of the International Symposium on Form and Function in Zoology, Bormio (Sondrio) October 2-4, 1989. Modena (Italia): Mucchi Editore, 1991.

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G, Bazán Nicolás, Botting Jack H i Vane John R, red. New targets in inflammation: Inhibitors of COX-2 or adhesion molecules : proceedings of a conference held on April 15-16, 1996, in New Orleans, USA, supported by an educational grant from Boehringer Ingelheim. Dordrecht: Kluwer Academic Publishers, 1996.

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Atreya, Hanudatta S., red. Isotope labeling in Biomolecular NMR. Dordrecht: Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4954-2.

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Misra, Gauri, red. Introduction to Biomolecular Structure and Biophysics. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-4968-2.

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Mesirov, Jill P., Klaus Schulten i De Witt Sumners, red. Mathematical Approaches to Biomolecular Structure and Dynamics. New York, NY: Springer New York, 1996. http://dx.doi.org/10.1007/978-1-4612-4066-2.

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Części książek na temat "Biomolecules 2"

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Bhutani, S. P. "Amino Acids, Peptides, and Proteins". W Chemistry of Biomolecules, 87–192. Second edition. | Boca Raton : CRC Press, 2019.: CRC Press, 2019. http://dx.doi.org/10.1201/9780429266423-2.

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Chen, Lin X. Q., i Graham R. Fleming. "Photophysics of the Tryptophan Residue in RNaseTl and RNase Tl-2′GMP Complex". W Fluorescent Biomolecules, 432. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5619-6_44.

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Disotell, Todd R. "Phylogenetic Relationships (Biomolecules)". W Handbook of Paleoanthropology, 1–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-27800-6_59-2.

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Bucci, Enrico, Henryk Malak, Clara Fronticelli, Ignacy Gryczynski i Joseph R. Lakowicz. "Resolution at 2 GHz of Lifetimes and Correlation Times of Highly Purified Solutions of Human Hemoglobin". W Fluorescent Biomolecules, 305–18. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4684-5619-6_17.

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Abo, Mitsuru, Li-ping He, Kae Sato i Akira Okubo. "Determination of Monosaccharides Derivatized with 2-Aminobenzoic Acid by Capillary Electrophoresis". W Capillary Electrophoresis of Biomolecules, 45–50. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-296-4_4.

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Iost, Rodrigo M. "Volume-Confined Biomolecules for Application in Biocatalysis". W Advances in Bioelectrochemistry Volume 2, 71–80. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-95270-9_4.

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Peesa, Jaya Preethi, i K. Saravanakumar. "A Comprehensive Review of Phytochemical Profile and Pharmacological Attributes of Scutia Myrtina (Burm.F.) Kurz." W Biomolecules and Pharmacology of Medicinal Plants, 17–25. New York: Apple Academic Press, 2023. http://dx.doi.org/10.1201/9781003284468-2.

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Homem, N. C., R. M. Paixão, C. S. Miranda, J. C. Antunes, M. T. P. Amorim i H. P. Felgueiras. "Potential Biomolecules of Microbial Origin Against Infectious Diseases". W Microbial Systematics, 14–42. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003307679-2.

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Gräslund, A., F. Claesens, L. W. McLaughlin, P. O. Lycksell, U. Larsson i R. Rigler. "NMR and Time Resolved Fluorescence Studies of a 2-Aminopurine Substituted Eco RI Restriction Site". W Structure, Dynamics and Function of Biomolecules, 201–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71705-5_43.

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MacKerell, Alexander D., Rudolf Rigler, Ulrich Hahn i Wolfram Saenger. "Ribonuclease T1: Interaction with 2’GMP and 3’GMP as Studied by Time-Resolved Fluorescence Spectroscopy". W Structure, Dynamics and Function of Biomolecules, 260–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71705-5_55.

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Streszczenia konferencji na temat "Biomolecules 2"

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Karnik, Rohit, Kenneth Castelino, Chuanhua Duan, Rong Fan, Peidong Yang i Arun Majumdar. "Nanofluidic Devices for Sensing and Flow Control". W ASME 4th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2006. http://dx.doi.org/10.1115/icnmm2006-96156.

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Nanofluidics is concerned with fluidic channels that are typically 1–100 nm in size. We have fabricated nanofluidic devices using both 1-D silica nanotubes and 2-D nanochannels to explore transport phenomena at the nanoscale. Here we review our work on 2-D nanochannels that provide confinement in one dimension. Our work mainly deals with two aspects of nanofluidics (a) effects related to electrostatic interactions and (b) effects related to biomolecule size. Surface charge plays an important role in nanofluidic channels, when the channel size is comparable to the Debye length. Using both electrical conductance measurements and fluorescence imaging, we studied the effects of surface charge in our nanofluidic devices, and demonstrated that the environment in nanochannels is governed by surface charge. We modified the nanochannel surface and showed that these modifications can be sensed by measuring ionic conductance of the nanochannels. Further, binding reactions involving biomolecules can be sensed at both low and high ionic concentrations. Our results showed that at low concentrations, conductance is governed by biomolecule charge, while at high concentrations it is governed by biomolecule size. Based on electrostatic effects in nanochannels, we also developed a nanofluidic transistor for flow control. This metal-oxide-solution field effect transistor was fabricated by patterning a metal gate electrode over nanochannels, similar to a MOSFET. Just as the gate voltage of a MOSFET controls carrier concentration in the semiconductor, we demonstrated that the gate voltage in a nanofluidic transistor controls the concentration of ions and biomolecules in the nanochannel, and hence controls their transport. Our fabrication process uses standard lithography, and is amenable to making networks of nanochannels. It suggests that rationally designed nanofluidic networks could be developed using this process for applications in sample preparation, sensing and switching. We are currently studying flow control and switching using field-effect, as well as ionic transport using patterned surface charge in nanofluidic devices.
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Wetzel, Christoph, Linda Jansen-Olliges, Carsten Zeilinger, Frank Surup, Marc Stadler i Bernhard Roth. "Surface enhanced Raman spectroscopy based analysis of SARS-CoV-2 spike protein binding to ACE2 receptor". W Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XXI, redaktorzy Attila Tarnok, Jessica P. Houston i Xuantao Su. SPIE, 2023. http://dx.doi.org/10.1117/12.2648954.

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Soldatovic, Tanja, i Enisa Selimovic. "Interaction of Zinc(II) and Copper(II) Terpyridine Complexes with Biomolecules". W 2nd International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecmc-2-a001.

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Schartner, Erik P. "New Tools for Measurement: Opportunities for Sensing Chemicals or Biomolecules with Optical Fibers". W Optical Sensors. Washington, D.C.: OSA, 2013. http://dx.doi.org/10.1364/sensors.2013.sm3c.2.

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Hosoi, Y., K. Takahashi, M. Biyani, N. Nemoto, T. Akagi i T. Ichiki. "High-throughput Screening of Mutant Biomolecules Using mRNA Display and Microreactor Array Chips". W 2005 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2005. http://dx.doi.org/10.7567/ssdm.2005.h-5-2.

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Reátegui, Eduardo, i Alptekin Aksan. "Effect of Kinetic and Thermodynamic Transitions of Confined Water on Biomolecules". W ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192376.

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In the last years, encapsulation of functional biomolecules (such as enzymes, proteins and antibodies) in three-dimensional nanoporous silica matrices has received considerable attention for its potential applications in biocatalysis, biosensing, and biopreservation.1 A handful of studies conducted with bacteria, plant, and mammalian cells have shown that these complex microorganisms can also function when they are encapsulated in silica matrices.2 When encapsulated in rigid permeable mesopores, mobility and proliferation of the microorganisms are prevented, while nutrients and by-products diffuse freely through the porous matrix. However, it is not known what mechanism(s) enables the biomolecules to be stable, and the microorganisms to be active, while they are mechanically confined in a matrix in a “no-growth” state. It is known that the motions and properties of water change when confined in nanopores. Therefore, we envision that the altered properties of confined water play a role in increasing the stability of biomolecules. This study is focused on understanding the effects of confinement on the kinetic and thermodynamic transitions of water, and identifying its effects on the structure of confined biomolecules. We have utilized Fourier Transform Infrared Spectroscopy (FTIR) to identify the different states and phase transitions of nanopore confined water at cryogenic temperatures. We have extended our analysis to quantify the structural changes in nanopore confined isolated and endogenous proteins of intact organisms.
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Kulinska, K., i A. Laaksonen. "Molecular dynamics simulation of cytidine: 2'-deoxycytidine and their phosphate salts in a water solution". W Laser Spectroscopy of Biomolecules: 4th International Conference on Laser Applications in Life Sciences, redaktor Jouko E. Korppi-Tommola. SPIE, 1993. http://dx.doi.org/10.1117/12.146147.

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Shim, Jin-Hyung, Jong Young Kim, Kyung Shin Kang, Jung Kyu Park, Sei Kwang Hahn i Dong-Woo Cho. "Development of HA-PLGA Scaffold Encapsulating Intact BMP-2 Using Solid Freeform Fabrication Technology". W ASME 2011 International Manufacturing Science and Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/msec2011-50259.

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Tissue engineering is an interdisciplinary field that focuses on restoring and repairing tissues or organs. Cells, scaffolds, and biomolecules are recognized as three main components of tissue engineering. Solid freeform fabrication (SFF) technology is required to fabricate three-dimensional (3D) porous scaffolds to provide a 3D environment for cellular activity. SFF technology is especially advantageous for achieving a fully interconnected, porous scaffold. Bone morphogenic protein-2 (BMP-2), an important biomolecule, is widely used in bone tissue engineering to enhance bone regeneration activity. However, methods for the direct incorporation of intact BMP-2 within 3D scaffolds are rare. In this work, 3D porous scaffolds with poly(lactic-co-glycolic acid) chemically grafted hyaluronic acid (HA-PLGA), in which intact BMP-2 was directly encapsulated, were successfully fabricated using SFF technology. BMP-2 was previously protected by poly(ethylene glycol) (PEG), and the BMP-2/PEG complex was incorporated in HA-PLGA using an organic solvent. The HAPLGA/PEG/BMP-2 mixture was dissolved in chloroform and deposited via a multi-head deposition system (MHDS), one type of SFF technology, to fabricate a scaffold for tissue engineering. An additional air blower system and suction were installed in the MHDS for the solvent-based fabrication method. An in vitro evaluation of BMP-2 release was conducted, and prolonged release of intact BMP-2, for up to 28 days, was confirmed. After confirmation of advanced proliferation of pre osteoblasts, a superior differentiation effect of the HA-PLGA/PEG/BMP-2 scaffold was validated by measuring high expression levels of bone-specific markers, such as alkaline phosphatase (ALP) and osteocalcin (OC). We show that our solvent-based fabrication is a non-toxic method for restoring cellular activity. Moreover, the HAPLGA/PEG/BMP-2 scaffold was effective for bone regeneration.
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Dutta, Prashanta. "Application of LASER in Detection and Manipulation of Biomolecules in Lab-on-a-Chip Devices". W Laser Applications to Chemical, Security and Environmental Analysis. Washington, D.C.: OSA, 2012. http://dx.doi.org/10.1364/lacsea.2012.lm3b.2.

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Okuno, Jun, Kenzo Maehashi, Kazuhiko Matsumoto, Kagan Kerman, Yuzuru Takamura i Eiichi Tamiya. "High-Sensitive and Label-Free Detection of Biomolecules Using Single-Walled Carbon Nanotube Modified Microelectrodes". W 2006 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2006. http://dx.doi.org/10.7567/ssdm.2006.a-6-2.

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Raporty organizacyjne na temat "Biomolecules 2"

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Roux, B., Y. Luo i W. Jiang. NAMD - The Engine for Large-Scale Classical MD Simulations of Biomolecular Systems Based on a Polarizable Force Field: ALCF-2 Early Science Program Technical Report. Office of Scientific and Technical Information (OSTI), maj 2013. http://dx.doi.org/10.2172/1079771.

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