Rozprawy doktorskie na temat „Biological treatment”
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Pouliot, Julie-Marie. "Biological treatment of landfill leachate". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0005/MQ42192.pdf.
Pełny tekst źródłaButler, Erick Benjamin. "Biological Treatment of Dietary Supplementary Wastewater". Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1264479316.
Pełny tekst źródłaButler, Erick Benjamin. "Biological treatment of dietary supplement wastewater". Cleveland, Ohio : Cleveland State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1264479316.
Pełny tekst źródłaAbstract. Title from PDF t.p. (viewed on Feb. 16, 2010). Includes bibliographical references (p. 82-89). Available online via the OhioLINK ETD Center and also available in print.
Kosovska, Halyna. "The Biological Treatment of Organic Food Waste". Thesis, KTH, Industriell ekologi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-32714.
Pełny tekst źródławww.ima.kth.se
Hung, Chien-ho. "Fate of thiocyanate in biological treatment processes". Thesis, Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/20864.
Pełny tekst źródłaWalker, Gavin Michael. "Industrial wastewater treatment using biological activated carbon". Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295433.
Pełny tekst źródłaEvans, Helen L. "Particle removal within biological water treatment filters". Thesis, University of Surrey, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298089.
Pełny tekst źródłaHou, Xiangting. "DIETARY SUPPLEMENT WASTEWATER TREATMENT BY BIOLOGICAL METHODS". Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1326295666.
Pełny tekst źródłaAlharthy, Basma Tarek. "Using biological tools to assess methadone treatment". Thesis, King's College London (University of London), 2015. https://kclpure.kcl.ac.uk/portal/en/theses/using-biological-tools-to-assess-methadone-treatment(d56826f4-bcaa-40e1-875e-c53151a65a41).html.
Pełny tekst źródłaAlattar, Manar Arica. "Biological Treatment of Leachates of Microaerobic Fermentation". PDXScholar, 2012. https://pdxscholar.library.pdx.edu/open_access_etds/905.
Pełny tekst źródłaSurgeoner, Donna Agnes. "Studies of rotating biological contactors". Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263488.
Pełny tekst źródłaBerktay, Ali. "The effects of pressure on aerobic biological wastewater treatment using rotating biological contractors". Thesis, Loughborough University, 1993. https://dspace.lboro.ac.uk/2134/11709.
Pełny tekst źródłaMulholland, Gary. "Pig Duodenum Derivative : biological properties". Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335588.
Pełny tekst źródłaAl-Momani, Fares. "Combination of photo-oxidation processes with biological treatment". Doctoral thesis, Universitat de Barcelona, 2003. http://hdl.handle.net/10803/1521.
Pełny tekst źródłathis fact, we disregard it by polluting our rivers, lakes, and oceans. Subsequently, we are
slowly but surely harming our planet to the point where organisms are dying at a very alarming rate. In addition to innocent organisms dying off, our drinking water has become greatly affected as is our ability to use water for recreational purposes. In order to combat water pollution, we must understand the problems and become part of the solution.
When is compared with other options of processing, biological treatment of residual
water is considered a cheap and attractive alternative to eliminate various types of
contaminants. The effíciency of the biological process depends on many factors such as
the concentration of the contaminants, the chemical structure of the composed, the pH
and the presence of inhibitory compounds in wastewater. Although some organic contaminants can be degraded through biological process, many other composed synthetic and natural are not biodegradable.
On the hand, several chemical processes as advanced oxidation processes (AOP's) can
be use for mineralization of many organic contaminants. The doubt that presents these
processes is the use of expensive reagents. A potential viable solution proposed during last two decays is the combination of these processes with biological processing. In these combined processes, the chemical process would be utilized like pre-treatment step to enhance the biodegradability and elimínate the toxicity of the effluents, while the total mineralization would be completed in the biological process. For it, it is interesting to monitor the changes in the biodegradability of the effluents along the
chemical process, this may be use to determine the optimum pre-treatment time. In the literature various indicators have been proposed to follow the biodegradability, where the ratios BOD5/COD and BOD5/TOC are the most utilized (BOD: Biological oxygen demand); COD: Chemical oxygen demand; TOC: total organic carbón). In general, are municipal wastewater was taken as reference values. Thus, it is considered that an effluent is biodegradable when the relation BOD5/COD is over 0.4 or BOD5/TOC over 1.0 (Metcalf & Eddy, 1985).
The AOP's are defined like those processes that imply the generation of radicals highly
reagents (especially radical hidroxilo) in suffícient quantities. Although most organic
matter can be degraded by these processes, other compounds as the acetic acids,maleico and oxálico, acetona or cloroformo are not attacked by these radicals (Bigda,1995). The advantage of AOP's comes from the fact that radicals can be formed through different processes.
In this study, AOP's based on photo-oxidation well be used for treatment of water contained Phenol and 2,4-dichlorophenol. In the first chapter of this work a general literature review the reactions are presented in which a series of methods for the treating refractory were proposed, among them is found the adsorption in active carbon, humid oxidation, supercritical oxidation, electrochemical oxidation, chemical oxidation in its two parts classics and advanced oxidation. For all, a small bibliographical search as well previous publication in elimination of phenol (POH) and 2,4-dichlorophenol
(DCP) are presented. Moreover, it was presented a basic explanation of the characteristics of the biological processing and its operational types. At the end of this chapter, it has been introduced a figure (Figure 3.4) that shows a possible strategy to treat any type of wastewater depending on the organic load and the biodegradability.
With respect to the results, the thesis present a framework of the combination of AOP's and biological treatment. In this case, synthetic residual water containing phenol (POH) and 2,4-diclorophenol (DCP) and textile dyes.These compound associates as contaminants in different types of water. They appear in different types of industrial effluents and included among the 130 priority contaminants gives by US EPA and the
European Union.
A study of the behaviour of these substances for a possible biological degradation showed that all presented low biodegradability, and some as the DCP and textile dyes were inhibited for biomass. Thus, it was necessary to seek alternatives treatment processes.
In a first part of this work, the degradation of these composed was studied by means of
advanced oxidation processes (AOP's), based on the use of the process of photo
oxidation, in this case, direct irradiation with light UV or UVA, and combination these
sources of light with; UV(A)/H202, UV(A)/Fe(III),UV(A)/Fe(II)/H202 and the process
Fenton. These experiments were performed in four different, two of them are type tubular and the other two are type stirred tank. The followed variables along the process were the concentration of the contaminants, pH, initial concentration of the H202, Conc. Initial of Fe(II), time of irradiation and total organic carbon (TOC).
The effect of irradiation time in the degradation of both the POH and DCP was studied. Also, kinetic of the reactions were followed. Results show that direct UV photolysis is not efficient for DCP and POH elimination. First order reaction constant of aprox.
0.0056 min-1 and 0.0066 min-1 was obtained for POH and DCP, respect.)
Also the combinations of this process with other hydroxyl radical sours were studied,
for e. j., the effect of the quantity of peroxide or Fa(II), or the black light irradiation
with UV at (300-420 nm) vs. 254 nm. By means of the combination H202/UV/Fe removals percentages of 100 DCP and POH were achieved. During these reactions, by-products were identified, for POH it was identified caticlos, quinone and hidroquinoin. In the case of DCP, only it was possible to identify the clorobenzoquinona and some carboxylic acids.
As it was mentiond above, the hostility that AOP's presents is use of expensive reagents, and a possible alternative is the combination with biological process. In this study also, some strategies for these types of combination have been established, that was possible by means of a study of the improvement in the biodegradability of the treated solutions. In a second part of the work, therefore, the effect of these processes
was studied in the biodegradability enhancement of the solutions. The better results
were obtained by means of the process photo-Fenton, the ratios BOD5/COD increased
from O up to 0.92 and 0.48 for solutions of 100 ppm of POH and DCP respectively.
After time of irradiation of 30 min and initial concentrations of H2 02 of 65 ppm and 300 ppm, respectively. Later the improvement of the biodegradability of the treated solutions, was studied the biodegradation of some solutions pre-tried of POH and DCP.
Respect the DCP treated, the results have shown that activated sludge of a municipal wastewater plant could be adequate for the treatment of the pre-oxidize solutions and that was possible through co-digestion of the same with a residual water. By means of the combination photo Fenton -biological treatment. It was achieved up to a 89 of organic matter elimination. Continuing this line of investigation, it was developed also
a complete combined processes consist of DCP pre-treated via Photo oxidation and aerobic and anaerobio biological reactors type SBR (sequencing batch reactor). By means of this process, elimination of organic matter up to 93 of TOC was obtained in a signifícant cycle time. The same strategy was applied to phenol, in this part a comparison has been established between single and coupled processes, the results have
been shown that good improvement in organic matter take place in the combined processes.
Finally, the use of the photo oxidation processes was examined to eliminate the colour and improvement the biodegradability of dyes solutions. The results have shown that these processes can be use efficiently for colour elimination and biodegradability improvement of dyes solutions.
Topkaya, Pinar. "Computer Simulation Of A Complete Biological Treatment Plant". Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12609708/index.pdf.
Pełny tekst źródłaCollings, Julia. "Sustainable technology for the biological treatment of waste". Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/30225.
Pełny tekst źródłaBatarseh, Eyad. "Chemical and Biological Treatment of Mature Landfill Leachate". Doctoral diss., University of Central Florida, 2006. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2698.
Pełny tekst źródłaPh.D.
Department of Civil and Environmental Engineering
Engineering and Computer Science
Environmental Engineering
Demjaha, Arsime. "Biological and clinical determinants of treatment resistant schizophrenia". Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/biological-and-clinical-determinants-of-treatment-resistant-schizophrenia(eeabcaab-e9c7-4d41-99e6-8428569f57d0).html.
Pełny tekst źródłaDo, Ngoc Thanh Thuy. "Biological treatment and recycling of textile processing effluents". Thesis, De Montfort University, 2004. http://hdl.handle.net/2086/13296.
Pełny tekst źródłaDe, Luca Leandra Anali. "Optimizing the nitrogen removal in leachate treatment during continuous-flow biological treatment (KBR)". Thesis, KTH, Industriell bioteknologi, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-298112.
Pełny tekst źródłaLandfilling has been one of the most popular methods of handling waste globally. Despite the efforts made to stop the disposal of household waste during the turn of the millennia, the landfills formed before these restrictions are still at risk for causing harm to the environment. In 2014, SÖRAB opened a continuous-flow biological treatment (KBR) facility in Löt to treat the leachate produced in one of their older landfills, once filled with household waste. Since then, SÖRAB has been working on improving the treatment facility. The aim of this the study is to find a suitable process to enhance the nitrogen removal at low temperature. Several laboratory scale experiments were performed, such as viability of microbial consortia in the leachate and growth at room temperature and at 4°C, testing bioaugmentation by enriching the microbial cell culture in the leachate and their efficiency in removing nitrogen, compared to the commercial cell culture ClearBlu Environmental and carbon source addition. The results displayed complete nitrification at both room temperature and 4°C in bioaugmented, enriched leachate originating from the L2A basin of the KBR facility, after five days. These trials also suggested the occurrence of aerated denitrification. Complete denitrification within five days was seen at room temperature in bioaugmented, enriched leachate from the L2B basin of the same facility. The ensuing pilot scale trials proved the possibility to revive the biological nitrogen removal by microbial cell culture enrichment. In one pilot in which leachate from the L2B basin was enriched, complete denitrification in the anaerobic phase consisting of 16 days occurred, along with some nitrification and aerated denitrification in the 17 day long aerated phase that followed. Another pilot scale trail in which leachate from the L2A basin was enriched, both aerobic and anaerobic nitrification occurred, as ammonium removal occurred in both the aerated and unaerated phases. The addition of nutrient broth might influence the KBR system which needs further study. The results from this project clearly demonstrate that nitrogen removal in the KBR facility could be enhanced using a culture naturally present in the facility.
Lumbers, Jeremy. "Rotating biological contactors : mechanisms, modelling and design". Thesis, Imperial College London, 1988. http://hdl.handle.net/10044/1/47161.
Pełny tekst źródłaLi, Wen. "Improvement of Biological Processes of Inland Municipal Wastewater Treatment Plant". Thesis, KTH, Mark- och vattenteknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-190742.
Pełny tekst źródłaTjernström, Linnéa. "Function of soil-based on-site wastewater treatment systems - Biological and chemical treatment capacity". Thesis, KTH, Mark- och vattenteknik (flyttat 20130630), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-210716.
Pełny tekst źródłaDecentraliserade system för rening av avloppsvatten är bland de huvudsakliga svenska antropogena källorna till näringsämnen som bidrar till övergödning av Östersjön. Bland decentraliserade system i Sverige är nästan hälften system med slamavskiljare följt av ett markbaserat system i vilket avloppsvattnet renas genom infiltration i jord. I denna studie studeras en markbaserad teknik i vilken avloppsvattnet filtreras genom sand, en så kallad markbädd. En fältundersökning gjordes där samlingsprov av ingående och utgående avloppsvatten togs på två markbäddar i Stockholmsområdet för att bestämma deras biologiska och kemiska reningsfunktion samt att jämföra avskiljningen av fosfor i systemen med rekommendationer från HaV. Parametrar som inkluderats i studien är totalfosfor, ammonium-kväve, löst organiskt kol, pH, turbiditet och löst syre. Biologisk funktion ansågs bra i båda markbäddarna eftersom nitrifikationen var hög och utgående vatten hade tillräckliga halter av löst syre vilket implicerar att markbäddarna var väl syresatta. Rådande syrerika förhållanden i markbäddarna antyder också att organiskt material bryts ned avsevärt, vilket är fallet för löst kol som reducerades med mer än 85 % i en av markbäddarna och med nästan 70 % i den andra. Den höga reduktionen av organiska mikroföroreningar som påvisats i markbäddarna i en annan studie tyder också på att biologisk funktion med avseende på avsklijning av organiska substanser är bra. Kemisk funktion, med avseende på avskiljning av totalfosfor, var inte tillräcklig då ingen av markbäddarna levde upp till reduktionskraven från HaV för normal eller hög skyddsnivå. Totalfosfor avskiljdes med 42 respektive 54 % i markbäddarna. En nackdel med metoden som användes i studien är att de resultat som fåtts för avkiljning av de olika parametrarna endast kan representera den verkliga situationen om variationer i in- och utgående flöde samt variationer i ingående vattenkoncentrationer är små och om utspädningseffekten av utgående vatten är försumbar.
Chai, Qian. "Modeling, estimation, and control of biological wastewater treatment plants". Doctoral thesis, Norwegian University of Science and Technology, Department of Engineering Cybernetics, 2008. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-2082.
Pełny tekst źródłaThe activated sludge process (ASP), as the most generally applied biological wastewater purification technique, attracts a great deal of attention from the research community in a highly populated, industrialized world. The main objective of this thesis is to investigate methods for e¢ cient development of activated sludge plant models and for possible improvements in process operation and performance through applications of advanced modeling and control techniques. Different topics in advanced control such as parameter estimation, state estimation, and model predictive control, are addressed, and the methods investigated in this thesis are illustrated with two activated sludge processes, a laboratory-scale nitrogen (N) removal plant and a full-scale phosphorus (P) removal plant: the Duvbacken wastewater treatment plant (WWTP).
As model representation is important in control oriented modeling, the object-oriented modeling approach providing open component-based architectures and reuse of components, is suggested in this thesis to achieve a more flexible model representation. The models of the N-removal process and the Duvbacken WWTP are developed based on the Activated Sludge Models (ASMs) which are generally accepted as the standard models of activated sludge processes (ASPs). The dynamic models are implemented in the object-oriented modeling language Modelica using the Dymola simulation environment, based on a modification of the Modelica library WasteWater. In order to build a good software development environment, special consideration is given to two Dymola interfaces: the Dymola-Matlab interface provided by Dymola and the Dymola-Python interface developed by the author. The application of the modeling approach in this thesis shows that the combination of Modelica/Dymola for efficient object-oriented modeling and Matlab for further analysis is a powerful tool for control system design.
The performances of some widely used state estimation techniques, such as the standard Kalman filter (KF), the extended Kalman filter (EKF), the unscented Kalman filter (UKF), the square-root unscented Kalman filter (SRUKF), and the moving horizon estimation (MHE), are evaluated with application to the N-removal process. The comparison of these filters for the N-removal process shows that the SRUKF improves numerical properties of the UKF and provides the best estimation performance, and the discrete-time EKF gives the fastest performance with a satisfactory estimation result. In addition, since a good characterization of the main compositions in the influent is very important to the performance of the ASM models, a method for simultaneously estimating both model state and influent composition (model disturbance) is developed using the discrete-time EKF and illustrated with the Duvbacken WWTP. The filter has a good convergence property for the observable process based on responses from the simulation model. However, when the filter is evaluated based on the experimental data, the performance of the filter is relatively poor due to unobservability of the system. Additional measurements are therefore needed to render the Duvbacken system locally observable.
Parameter estimation of activated sludge plant models is a challenging task, since the models are in general large-scale, nonlinear, and overparameterized. A procedure for parameter identifiability analysis is discussed and tested with the Duvbacken model. This systematic method proves to be very useful, since it reduces a large number of parameters to a small subset of parameters that can be identified from the available experimental data. The fitting of the model to real data from the industrial plant is not great but satisfactory, especially for those outputs which are important to the plant operation (e.g. concentration of phosphate SPO4 and concentration of total phosphorus TP).
Advanced control strategies for the ASP aeration system are suggested with the focus on the MPC algorithm, since MPC provides an optimization-based procedure with an elegant way of handling constraints and with capabilities of removing process disturbances. Both linear and nonlinear MPC techniques are evaluated with the N-removal process, and the simulation results show that the performances of the MPC controllers are satisfactory: the controllers guarantee that the strict e uent requirements are fulfilled. The nonlinear MPC strategy is also compared with some conventional rule-based controllers, and the MPC controller shows the most reduction of the energy consumption and offers the easiest way to handle the inequality constraints.
Finally, recommendations for future research directions are suggested to an N-removal project group at Telemark University College, Norway.
Paper B reproduced with kind permission of Elsevier
Muz, Melis. "Ozone Treatment Of Excess Biological Sludge And Xenobiotics Removal". Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614310/index.pdf.
Pełny tekst źródłaSheth, Ken S. "Biological treatment of heavy metals using sulfate reducing bacteria". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0019/MQ52663.pdf.
Pełny tekst źródłaTolley, M. R. "The biological treatment of liquid wastes containing heavy metals". Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335844.
Pełny tekst źródłaAmini-Rad, Hassan. "An experimental study of air scour in biological treatment". Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336735.
Pełny tekst źródłaBarbosa, Vera Lucia. "Biological treatment of hydrogen sulphide by activated sludge diffusion". Thesis, Cranfield University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.422391.
Pełny tekst źródłaSmith, Rona Marie. "Biological therapy in the treatment of ANCA associated vasculitis". Thesis, University of Cambridge, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709472.
Pełny tekst źródłaAboobakar, Amina. "Quantification of greenhouse gas emissions in biological wastewater treatment". Thesis, Cranfield University, 2014. http://dspace.lib.cranfield.ac.uk/handle/1826/8494.
Pełny tekst źródłaCoughtrie, Andrew Robert. "Coupling hydrodynamic and biological process models for wastewater treatment". Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16207/.
Pełny tekst źródłaKuhn, David Dwight. "Enhancing Aquaculture Sustainability Through Water Reuse and Biological Treatment". Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/26723.
Pełny tekst źródłaPh. D.
Zivich, Jamie Dionne. "Biological Health Assessment of an Industrial Wastewater Treatment Facility". Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/43523.
Pełny tekst źródłaMaster of Science
Bi, Tianzhu. "Biological Treatment of Milk and Soybean Wastewater with Bioproducts". Cleveland State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=csu1292017443.
Pełny tekst źródłaWolfe, Christopher L. "Biological and physical treatment of crab processing industry wastewaters". Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-08042009-040526/.
Pełny tekst źródłaLubkowitz, Erika M. "Biological treatment schemes for preventing oxime inhibition of nitrification". Thesis, This resource online, 1996. http://scholar.lib.vt.edu/theses/available/etd-10022008-063211/.
Pełny tekst źródłaKang, Young Woon. "Biological treatment of turkey processing wastewater with sand filtration". Columbus, Ohio : Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1078903968.
Pełny tekst źródłaTitle from first page of PDF file. Document formatted into pages; contains xxi, 187 p.; also includes graphic (some col.). Includes abstract and vita. Advisor: Karen M. Mancl, Dept. of Food, Agricultural, and Biological Engineering. Includes bibliographical references (p. 169-178).
Kent, Tanya Denise. "The effect of media size on biological aerated filter performance". Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287176.
Pełny tekst źródłaBasu, Pradipta Ranjan. "Evaluation of biological treatment for the degradation of petroleum hydrocarbons in a wastewater treatment plant". Texas A&M University, 2005. http://hdl.handle.net/1969.1/2418.
Pełny tekst źródłaChristian, Sarah Jeung soon. "Meta-Analysis of the Effectiveness of Biological and Non-Biological Treatments for Postpartum Depression". BYU ScholarsArchive, 2013. https://scholarsarchive.byu.edu/etd/3571.
Pełny tekst źródłaKumar, Mandeep. "Chemical and biological treatment of wastewater from N, N’- Dintrosopentamethylenetetramine manufacturing industries". Thesis, IIT Delhi, 2019. http://eprint.iitd.ac.in:80//handle/2074/8037.
Pełny tekst źródłaHodges, Alan J. "Alternative Treatment Technologies for Low-Cost Industrial and Municipal Wastewater Management". DigitalCommons@USU, 2017. https://digitalcommons.usu.edu/etd/5884.
Pełny tekst źródłaMehta, Naveen K. Ph D. Massachusetts Institute of Technology. "Engineering more potent vaccines for the treatment of cancer and autoimmunity". Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/123065.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references (pages 171-181).
Vaccination against infectious diseases has long been heralded as one of the greatest advancements in public health, yet its application to other clinical indications has fallen short of expectations. In this thesis, we apply engineering principles to develop more potent vaccines in the treatment of cancer and autoimmunity. Both major components of molecular vaccines, antigen and adjuvant, are independently explored as a part of this work. Our antigen studies sought to improve the delivery of peptide epitopes to lymphoid organs by fusing epitopes to inert protein carriers with defined pharmacokinetic properties. To promote anti-tumor immunity, we found that antigen carriers should 1) protect peptide cargo from proteolytic degradation, 2) be appropriately bulky to drain into the lymphatics, and 3) be rapidly cleared once in the blood to prevent tolerization at distal poorly inflamed organs.
Applying these principles, we identified transthyretin as an optimal delivery protein, and demonstrated efficacy against a number of clinically relevant antigens. Because our protein-epitope fusion approach is fully recombinant in nature, we were able to convert our protein vaccines into nucleic acid modalities, including plasmid DNA and self-replicating RNA, which are significantly easier and cheaper to manufacture at scale. Finally, we applied our learnings to purposefully induce tolerization in the treatment of autoimmunity, and found that albumin is a particularly efficacious antigen carrier protein for this application due to its extended half-life. On the adjuvant front, we attempted to engineer novel Toll-like receptor 3 (TLR3) agonists via yeast surface display. Although we successfully developed high affinity TLR3 binders, all tested clones failed to agonize TLR3 despite the utilization of several multimerization strategies.
Separately, in an effort to better understand adjuvant biology, we conducted a detailed mechanistic study of lipo-CpG, a particularly potent amphiphilic CpG variant previously developed by the Irvine lab. We uncovered a cascade of inflammatory signals originating from monocytes that facilitates the induction of high magnitude T cell responses, largely by acting in trans rather than directly on the antigen-presenting cell. Overall, these studies have elucidated a number of design principles that should aid in the engineering of next generation vaccines to better treat cancer and autoimmunity.
by Naveen K. Mehta.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Biological Engineering
Padron, Harold. "Combined anaerobic/aerobic treatment for municipal wastewater". ScholarWorks@UNO, 2004. http://louisdl.louislibraries.org/u?/NOD,110.
Pełny tekst źródłaTitle from electronic submission form. "A thesis ... in partial fulfillment of the requirements for the degree of Master of Science in the Environmental Engineering Program."--Thesis t.p. Vita. Includes bibliographical references.
Elving, Josefine. "Pathogen inactivation and regrowth in organic waste during biological treatment /". SLU : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2009. http://epsilon.slu.se/11652700.pdf.
Pełny tekst źródłaCodal, Ahmet. "Modeling Of Nitrogen Removal In A Membrane Biological Treatment Process". Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/2/12610212/index.pdf.
Pełny tekst źródłathe reason for this might be the inadequate available data on nitrification-denitrification process occurring in the system.
Bérubé, Pierre. "High temperature biological treatment of foul evaporator condensate for reuse". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0028/NQ48606.pdf.
Pełny tekst źródłaMendoza, Espinosa Leopoldo Guillermo. "Upflow and downflow biological aerated filters (BAFs) for wastewater treatment". Thesis, Cranfield University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268131.
Pełny tekst źródłaUapipatanakul, Boontida. "Harmonising metalworking fluid formulations with end-of-life biological treatment". Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:83a01f43-e9e2-42cb-a23c-cbc31b3ba1b5.
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