Rozprawy doktorskie na temat „Biochemistry”
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Suttisansanee, Uthaiwan. "Biochemistry in Bacterioferritin". Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2983.
Pełny tekst źródłaHoh, Hon Bing. "Biochemistry of keratoconus". Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266879.
Pełny tekst źródłaChen, Xiaoren. "Biochemistry of Prox1 function /". Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 160 p, 2007. http://proquest.umi.com/pqdweb?did=1456284231&sid=8&Fmt=2&clientId=8331&RQT=309&VName=PQD.
Pełny tekst źródłaRix, Louise Katharine. "Biochemistry of heart disease". Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334889.
Pełny tekst źródłaChapman, A. "Biochemistry of Trichomonas vaginalis". Thesis, Bucks New University, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373578.
Pełny tekst źródłaLawrence, Fiona Jane. "The biochemistry of keratoconus". Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268784.
Pełny tekst źródłaBeacham, Tracey. "Biochemistry of transgenic wheats". Thesis, Cardiff University, 2006. http://orca.cf.ac.uk/55160/.
Pełny tekst źródłaHuang, Po-Ssu Rees Douglas C. "Biochemistry and molecular biophysics /". Diss., Pasadena, Calif. : California Institute of Technology, 2004. http://resolver.caltech.edu/CaltechETD:etd-06012004-214823.
Pełny tekst źródłaWoodhouse, Jennifer Ann. "Plutonium pharmacokinetics and blood biochemistry". Thesis, University of Central Lancashire, 1997. http://clok.uclan.ac.uk/20148/.
Pełny tekst źródłaNasir-ud-Din. "Glycoconjugate biochemistry : structure-function relationship". Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/27105.
Pełny tekst źródłaLocklin, Rachel M. S. "Biochemistry of bone cell differentiation". Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363755.
Pełny tekst źródłaDavis, Jason John. "Fullerene biochemistry and surface investigations". Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244592.
Pełny tekst źródłaParker, David Alan. "Metabonomic studies in nutritional biochemistry". Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500322.
Pełny tekst źródłaWehrfitz, Josa-Marie. "The biochemistry of heterotrophic nitrification". Thesis, University of East Anglia, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318038.
Pełny tekst źródłaSpringer, Sebastian Hartmut. "The biochemistry of antigen presentation". Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:34d1afd2-fafc-4732-8e43-e00dcd8460d1.
Pełny tekst źródłaVuillard, Laurent Michel Marie. "The biochemistry of connective tissue". Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/19376.
Pełny tekst źródłaYap, Ivan Kok-Seng. "Integrated metabonomic studies in liver biochemistry". Thesis, Imperial College London, 2005. http://hdl.handle.net/10044/1/8902.
Pełny tekst źródłaSong, Jina. "Coagulation factor V : pathology and biochemistry". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/5595.
Pełny tekst źródłaNabbs, Brent Kenneth. "The chemistry and biochemistry of hydroxymethylpyrroles". Thesis, University of Canterbury. Chemistry, 1999. http://hdl.handle.net/10092/7302.
Pełny tekst źródłaLone, Anna Mari. "The Biochemistry and Physiology of Peptidases". Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10693.
Pełny tekst źródłaChemistry and Chemical Biology
Jordan, Peter A. "Physico-chemical studies of aluminium biochemistry". Thesis, University of East Anglia, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294654.
Pełny tekst źródłaBailey, A. C. "Biochemistry and pharmacology of beta-bungarotoxin". Thesis, University of Essex, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372585.
Pełny tekst źródłaFoster, S. J. "Biochemistry of Bacillus megaterium spore germination". Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384466.
Pełny tekst źródłaDuvold, Tore. "Chemistry and biochemistry of bacterial isoprenoids". Université Louis Pasteur (Strasbourg) (1971-2008), 1997. http://www.theses.fr/1997STR13195.
Pełny tekst źródłaPearce, Nicholas David. "An investigation of biochemistry higher education as a process of socialisation into the culture of the biochemistry community". Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396269.
Pełny tekst źródłaEngström, Gunnar. "Temperamental diagnostics and biochemistry in suicide attempters". Lund : Dept. of Clinical Neuroscience, Division of Psychiatry, University Hospital, 1997. http://books.google.com/books?id=y9lrAAAAMAAJ.
Pełny tekst źródłaMessier, Marc D. "The chemistry and biochemistry of aromatase inhibitors". Thesis, University of Ottawa (Canada), 1993. http://hdl.handle.net/10393/6735.
Pełny tekst źródłaAbebe, Adal T. "Biochemistry of 1,2-dehydro-n-acetyldopamine derivatives". Thesis, University of Massachusetts Boston, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3564657.
Pełny tekst źródłaDehydrodopa/dopamine derivatives form an important group of biomolecules participating in sclerotization of all arthropod cuticles, gluing and cementing mussels and related organisms to solid surfaces, and defense reactions of countless marine and invertebrate organisms. Yet very little information is available on the biochemistry of these highly reactive and unstable molecules. To understand their physiological role, I conducted a thorough biochemical study on three representative compounds that cover the entire plethora of dehydrodopa/dopamine derivatives. Employing diode array UV-visible spectroscopy, HPLC, liquid chromatography-mass spectrometry, and electrospray ionization tandem mass spectrometry, I investigated the oxidation chemistry of 1,2-dehydro-N-acetyldopamine (dehydro NADA), 1,2-dehydro-N-acetyldopa and 1,2-dehydro-N-acetyldopa methyl ester. Tyrosinase converted dehydro NADA to a reactive quinone methide that formed oligomeric products with the parent compound. The sister enzyme laccase, produced semiquinone radicals that exhibited a novel coupling reaction producing just dimers. Nonenzymatic oxidation of dehydro NADA also produced semiquinone radicals that formed oligomeric products. Moreover, nonenzymatic oxidation resulted in the production of superoxide anions that could function in defense reactions. The nonenzymatic oxidation studies on dehydro NADA at mild alkaline conditions revealed the mechanisms of defense reactions and tunic formation in a vast array of tunicates. Oxidative transformations of 1,2-dehydro-N-acetyldopa indicated a new route for the biosynthesis of a vast array of bioactive marine molecules possessing dihydroxycoumarin skeleton. In addition, it revealed new transformations of coumarins to oligomeric products via highly reactive quinone methide intermediates. Biochemical studies on 1,2-dehydro-N-acetyldopa methyl ester revealed a new Diels Alder type condensation of its quinone with the parent compound. This reaction shed light on the mode of gluing of mussels and other bivalves to solid surfaces as well as the hardening reactions occurring in their periostracum. I also examined the oxidation chemistry of dehydro NADA with a model nucleophile, N-acetylcysteine and discovered yet another new addition reaction of dehydro NADA that has tremendous biological significance. Finally, I investigated the mechanism of dehydro NADA binding to insect cuticle using labeled compounds and established that they could uniquely produce ketocatecholic compound, arterenone upon hydrolysis. The biochemical significances of all these new reactions are discussed in the dissertation.
Partington, Joanna Clair. "Biochemistry and molecular biology of potato bruising". Thesis, Royal Holloway, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265182.
Pełny tekst źródłaBaverstock, Jenny. "Biochemistry of visual transduction in squid photoreceptors". Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302983.
Pełny tekst źródłaLangmack, Keith Antony. "Structure and biochemistry of squid photoreceptor microvilli". Thesis, University of Oxford, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253282.
Pełny tekst źródłaChannell, Guy Andrew. "Oxidative flavour chemistry and biochemistry in parsley". Thesis, University of Nottingham, 1996. http://eprints.nottingham.ac.uk/13970/.
Pełny tekst źródłaBhatia, Jeetendra. "Biochemistry of visual transduction in cuttlefish receptors". Thesis, Birkbeck (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271670.
Pełny tekst źródłaBrown, Andrew M. G. "Biochemistry, tissue culture and pharmacology of Tanacetum". Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363563.
Pełny tekst źródłaBuckberry, Lorraine Dawn. "The biochemistry of mammalian C-S lyases". Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276184.
Pełny tekst źródłaShams, Saleema Bashir. "Some new micro analytical techniques in biochemistry". Thesis, University of Salford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245056.
Pełny tekst źródłaLaw, Samantha P. "The microbial biochemistry of slow sand filters". Thesis, Robert Gordon University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270109.
Pełny tekst źródłaPartridge, Robert James. "The biochemistry of the bovine preimplantation embryo". Thesis, University of York, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245866.
Pełny tekst źródłaTaylor, Stephen Murray. "Rheology and biochemistry of whey protein gels". Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308255.
Pełny tekst źródłaRastall, Robert A. "The cell surface biochemistry of Erwinia amylovora". Thesis, University of Greenwich, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258366.
Pełny tekst źródłaMcGeary, Sean E. (Sean Edward). "Understanding microRNA targeting with high-throughput biochemistry". Thesis, Massachusetts Institute of Technology, 2021. https://hdl.handle.net/1721.1/130661.
Pełny tekst źródłaCataloged from the official PDF of thesis. Vita.
Includes bibliographical references.
MicroRNAs (miRNAs) are short RNAs that, in complex with Argonaute (AGO) proteins, guide repression of mRNA targets. miRNAs negatively regulate most mammalian mRNAs, and disruption of this regulation often results in severe defects at the cellular and organismal level. miRNA repression occurs primarily through base-pairing between the miRNA seed region (nucleotides 2-8) and mRNA 3'-UTR sites, leading to transient recruitment of mRNA-destabilizing factors. However, only a small fraction of the gene-expression changes caused by a miRNA can currently be predicted, which precludes a deeper understanding of how miRNA regulation impacts the animal transcriptome. miRNA targeting efficacy should in principle be a function of the affinity between AGO-miRNA complexes and their targets. However, only a few such measurements had been reported, with measured values differing from those predicted for RNA-RNA pairing in solution.
We therefore adapted a high-throughput biochemical platform utilizing random-sequence RNA libraries to obtain the vast quantity of affinity values required to predict miRNA targeting efficacy. Through a novel analytical approach, we assigned relative dissociation (K[subscript D]) constants to all binding sites -12 nt in length, for six miRNAs. These analyses revealed unanticipated miRNA-specific differences in the affinity of similar sites, unique sites for different miRNAs, and a 100-fold influence of flanking dinucleotide context surrounding a site. These measurements informed a biochemical model of miRNA targeting that outperformed all existing models of miRNA targeting, which was extended to all miRNAs using a convolutional neural network (CNN) trained on both affinity and repression data. We also applied this high-throughput biochemical approach to understand the role of the miRNA 3' region using partially random RNA libraries.
We found unique 3'-pairing preferences for each miRNA, and evidence for two distinct binding modes. The miRNA-specific differences and two binding modes depended on G nucleotides in the miRNA 3' region, thus providing a heuristic by which to extend these findings to target prediction in vivo. This work establishes high-throughput biochemistry combined with mathematical modeling and deep learning as a powerful paradigm for building quantitative models of gene regulation, which might aid in eventually building a complete model of the cell.
by Sean E. McGeary.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Biology
Darkwa, Alfred Anthony. "Growth and biochemistry of hardy European orchids". Thesis, University of Sussex, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495011.
Pełny tekst źródłaOikonomou, Eftychia. "Molecular biology and biochemistry of brain tumours". Thesis, Aston University, 2004. http://publications.aston.ac.uk/11021/.
Pełny tekst źródłaChurchill, Thomas Allen Carleton University Dissertation Biology. "Metabolic biochemistry of freeze tolerance in vertebrates". Ottawa, 1992.
Znajdź pełny tekst źródłaBunn, Tristan. "Prion protein biochemistry in Creutzfeldt-Jakob disease". Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23281.
Pełny tekst źródłaJones, Colleen P. "Biochemistry of Selenium in Pariette Wetlands, Utah". DigitalCommons@USU, 2014. https://digitalcommons.usu.edu/etd/3303.
Pełny tekst źródłaCarlsson, Jens. "Challenges in Computational Biochemistry: Solvation and Ligand Binding". Doctoral thesis, Uppsala University, Department of Cell and Molecular Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8738.
Pełny tekst źródłaAccurate calculations of free energies for molecular association and solvation are important for the understanding of biochemical processes, and are useful in many pharmaceutical applications. In this thesis, molecular dynamics (MD) simulations are used to calculate thermodynamic properties for solvation and ligand binding.
The thermodynamic integration technique is used to calculate pKa values for three aspartic acid residues in two different proteins. MD simulations are carried out in explicit and Generalized-Born continuum solvent. The calculated pKa values are in qualitative agreement with experiment in both cases. A combination of MD simulations and a continuum electrostatics method is applied to examine pKa shifts in wild-type and mutant epoxide hydrolase. The calculated pKa values support a model that can explain some of the pH dependent properties of this enzyme.
Development of the linear interaction energy (LIE) method for calculating solvation and binding free energies is presented. A new model for estimating the electrostatic term in the LIE method is derived and is shown to reproduce experimental free energies of hydration. An LIE method based on a continuum solvent representation is also developed and it is shown to reproduce binding free energies for inhibitors of a malaria enzyme. The possibility of using a combination of docking, MD and the LIE method to predict binding affinities for large datasets of ligands is also investigated. Good agreement with experiment is found for a set of non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Approaches for decomposing solvation and binding free energies into enthalpic and entropic components are also examined. Methods for calculating the translational and rotational binding entropies for a ligand are presented. The possibility to calculate ion hydration free energies and entropies for alkali metal ions by using rigorous free energy techniques is also investigated and the results agree well with experimental data.
Thong, Kam-Wah. "Biochemistry of sulphur-containing amino acids in trichomonads". Thesis, University of Glasgow, 1986. http://theses.gla.ac.uk/1635/.
Pełny tekst źródłaMiller, S. Shea. "Oat beta-glucan: Biochemistry, structure and genetic variation". Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7507.
Pełny tekst źródłaKelly, Ronan. "Biophysics and biochemistry of the pancreatic β-cell". Thesis, University of Oxford, 1989. https://ora.ox.ac.uk/objects/uuid:e815cdec-ad16-4271-84e8-4ec8aaac842e.
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