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Artykuły w czasopismach na temat "Biochemistry and cell biology not elsewhere classified"
Ho, Gwendolyn, Ted Wun, Qian Li, Ann M. Brunson, Aaron S. Rosenberg, Brian Jonas i Theresa Keegan. "Decreased Early Mortality Associated with Treatment of Acute Myeloid Leukemia (AML) at NCI-Designated Cancer Centers in California". Blood 128, nr 22 (2.12.2016): 391. http://dx.doi.org/10.1182/blood.v128.22.391.391.
Pełny tekst źródłaAtrash, Shebli, Qing Zhang, Xenofon Papanikolaou, Christoph Heuck, Aziz Bakhous, Jameel Muzaffar, Al-Ola Abdallah i Bart Barlogie. "Characteristics and Prognosis Of IgM Multiple Myeloma". Blood 122, nr 21 (15.11.2013): 1881. http://dx.doi.org/10.1182/blood.v122.21.1881.1881.
Pełny tekst źródłaGallamini, Andrea, Alessandro Rambaldi, Alberto Biggi, Silvia Tavera, Caterina Patti, Caterina Stelitano, Alessandro M. Gianni i in. "BEACOPP Chemotherapy Is Able to Induce Durable Complete Remission in Poor-Prognosis Hodgkin’s Lymphoma Patients with a Positive Interim PET after 2 ABVD Cycles". Blood 112, nr 11 (16.11.2008): 2594. http://dx.doi.org/10.1182/blood.v112.11.2594.2594.
Pełny tekst źródłaRotulo, Gioacchino Andrea, Blandine Beaupain i Jean Donadieu. "ELANE Neutropenia Beyond the Classification into Cyclic Neutropenia and Severe Congenital Neutropenia: The Inconstant Time Clock". Blood 138, Supplement 1 (5.11.2021): 986. http://dx.doi.org/10.1182/blood-2021-149759.
Pełny tekst źródłaMasarova, Lucia, Prithviraj Bose, Naveen Pemmaraju, Zeev E. Estrov, Lingsha Zhou, Sherry A. Pierce, Jorge E. Cortes, Hagop M. Kantarjian i Srdan Verstovsek. "Evaluation of Cytogenetic Stratifications in Myelofibrosis". Blood 132, Supplement 1 (29.11.2018): 1763. http://dx.doi.org/10.1182/blood-2018-99-120225.
Pełny tekst źródłaNakano, Nobuaki, Hiroo Katsuya, Takahiro Itoyama, Mototsugu Shimokawa, Atae Utsunomiya, Shuichi Hanada, Tetsuya Eto i in. "Impact of Chromosomal Abnormalities in Acute and Lymphoma Types Adult T-Cell Leukemia-Lymphoma". Blood 128, nr 22 (2.12.2016): 4123. http://dx.doi.org/10.1182/blood.v128.22.4123.4123.
Pełny tekst źródłaTomlins, Jo, Nick Telford, Mike Dennis, Tim Somervaille, Adrian Bloor, Jim Cavet, Mike Green, Sven Armin Sommerfeld, John Murray i Samar Kulkarni. "Population Based Study of Cytogenetic Abnormalities in Addition to Philadelphia (Ph) Chromosome in Patients with Chronic Myeloid Leukaemia (CML) and Impact on Survival". Blood 124, nr 21 (6.12.2014): 4567. http://dx.doi.org/10.1182/blood.v124.21.4567.4567.
Pełny tekst źródłaWoyach, Jennifer A., Daphne Guinn, Amy S. Ruppert, James S. Blachly, Arletta Lozanski, Nyla A. Heerema, Weiqiang Zhao i in. "the Development and Expansion of Resistant Subclones Precedes Relapse during Ibrutinib Therapy in Patients with CLL". Blood 128, nr 22 (2.12.2016): 55. http://dx.doi.org/10.1182/blood.v128.22.55.55.
Pełny tekst źródłaSaskin, Aliza, Yulia Lin, Richard A. Wells, Martha Lenis, Alex Mamedov, Jeannie Callum i Rena Buckstein. "Prophylactic Rh and Kell Antigen Matching Significantly Decreases Rates of Alloimmunization in Transfusion Dependent MDS Patients". Blood 124, nr 21 (6.12.2014): 4297. http://dx.doi.org/10.1182/blood.v124.21.4297.4297.
Pełny tekst źródłaGirnius, Saulius K., Habte A. Yimer, Stephen J. Noga, Sudhir Manda, Roger M. Lyons, Kimberly Bogard, Presley Whidden i in. "In-Class Transition (iCT) from Parenteral Bortezomib to Oral Ixazomib Proteasome Inhibitor (PI) Therapy Increases the Feasibility of Long-Term PI Treatment and Benefit for Newly Diagnosed Multiple Myeloma (NDMM) Patients in an Outpatient Setting: Updated Real-World Results from the Community-Based United States (US) MM-6 Study". Blood 136, Supplement 1 (5.11.2020): 2–4. http://dx.doi.org/10.1182/blood-2020-140482.
Pełny tekst źródłaRozprawy doktorskie na temat "Biochemistry and cell biology not elsewhere classified"
Wang, Yu. "The development of a novel on-line system for the monitoring and control of fermentation processes". Thesis, University of Bedfordshire, 1995. http://hdl.handle.net/10547/610796.
Pełny tekst źródłaMuir, Matthew Stewart. "Proteomics of the ovine cataract". Diss., Lincoln University, 2008. http://hdl.handle.net/10182/792.
Pełny tekst źródłaHatchell, Hayley. "The relationship between docohexanoic acid (DHA) and L-serine, providing an insight into the biochemistry of meningioma". Thesis, University of Central Lancashire, 2017. http://clok.uclan.ac.uk/23985/.
Pełny tekst źródłaMitchell, Anthony Frank. "An investigation into the microbial bioconversion of cellulosic waste". Thesis, University of Central Lancashire, 1986. http://clok.uclan.ac.uk/19063/.
Pełny tekst źródłaBenny, Athol Graeme. "An integrated process for the recovery of clinically significant trace proteins from human plasma". 1990. http://hdl.handle.net/2292/2157.
Pełny tekst źródła(11198013), Kevin Wee. "Creation, deconstruction, and evaluation of a biochemistry animation about the role of the actin cytoskeleton in cell motility". Thesis, 2021.
Znajdź pełny tekst źródłaExternal representations (ERs) used in science education are multimodal ensembles consisting of design elements to convey educational meanings to the audience. As an example of a dynamic ER, an animation presenting its content features (i.e., scientific concepts) via varying the feature’s depiction over time. A production team invited the dissertation author to inspect their creation of a biochemistry animation about the role of the actin cytoskeleton in cell motility and the animation’s implication on learning. To address this, the author developed a four-step methodology entitled the Multimodal Variation Analysis of Dynamic External Representations (MVADER) that deconstructs the animation’s content and design to inspect how each content feature is conveyed via the animation’s design elements.
This dissertation research investigated the actin animation’s educational value and the MVADER’s utility in animation evaluation. The research design was guided by descriptive case study methodology and an integrated framework consisting of the variation theory, multimodal analysis, and visual analytics. As stated above, the animation was analyzed using MVADER. The development of the actin animation and the content features the production team members intended to convey via the animation were studied by analyzing the communication records between the members, observing the team meetings, and interviewing the members individually. Furthermore, students’ learning experiences from watching the animation were examined via semi-structured interviews coupled with post- storyboarding. Moreover, the instructions of MVADER and its applications in studying the actin animation were reviewed to determine the MVADER’s usefulness as an animation evaluation tool.
Findings of this research indicate that the three educators in the production team intended the actin animation to convey forty-three content features to the undergraduate biology students. At least 50% of the student who participated in this thesis learned thirty-five of these forty-three (> 80%) features. Evidence suggests that the animation’s effectiveness to convey its features was associated with the features’ depiction time, the number of identified design elements applied to depict the features, and the features’ variation of depiction over time.
Additionally, one-third of the student participants made similar mistakes regarding two content features after watching the actin animation: the F-actin elongation and the F-actin crosslink structure in lamellipodia. The analysis reveals the animation’s potential design flaws that might have contributed to these common misconceptions. Furthermore, two disruptors to the creation process and the educational value of the actin animation were identified: the vagueness of the learning goals and the designer’s placement of the animation’s beauty over its reach to the learning goals. The vagueness of the learning goals hampered the narration scripting process. On the other hand, the designer’s prioritization of the animation’s aesthetic led to the inclusion of a “beauty shot” in the animation that caused students’ confusion.
MVADER was used to examine the content, design, and their relationships in the actin animation at multiple aspects and granularities. The result of MVADER was compared with the students’ learning outcomes from watching the animation to identify the characteristics of content’s depiction that were constructive and disruptive to learning. These findings led to several practical recommendations to teach using the actin animation and create educational ERs.
To conclude, this dissertation discloses the connections between the creation process, the content and design, and the educational implication of a biochemistry animation. It also introduces MVADER as a novel ER analysis tool to the education research and visualization communities. MVADER can be applied in various formats of static and dynamic ERs and beyond the disciplines of biology and chemistry.
(8082788), Ruixin Wang. "A Novel Mechanism for Prostate Cancer Progression: from Polo-like Kinase 1 to Epigenetics". Thesis, 2019.
Znajdź pełny tekst źródłaProstate cancer is (PCa) the second leading cause of cancer death in males in the United State, with 174,650 new cases and 31,620 deaths estimated in 2019. Polo-like kinase 1 (PLK1) has been postulated to have a pro-tumorigenesis function, besides its critical role in regulation of cell cycle, and to be overexpressed in various types of human cancer, including prostate cancer (PCa). However, our understanding remains unclear regarding the pro-tumor properties of PLK1 partially due to a lack of proper animal model. Integrating our recently generated prostate-specific PLK1 knock-in genetically engineered mouse model (GEM) and the transcriptome data of human PCa patients, we identify an oncogenic role of PLK1 in the prostate adenocarcinoma progression, castration resistance and metastatic dissemination. To elucidate the underlying mechanism, we investigate the link between PLK1 and tumor microenvironment in PCa using the transgenic mouse model, and find that PLK1overexpression enable the macrophages polarization towards M2 phenotype via driving the activation of IL4/IL13/STAT6 pathway. These findings first validates PLK1 as a critical oncogene closely associated with PCa progression in vivo, and uncover a novel function of PLK1 to facilitate IL4/STAT6 signaling and M2 macrophage polarization. Importantly, these findings suggest an efficient therapeutic strategy targeting STAT6 for treatment of advanced PCa which usually possessing a high level of PLK1 expression. To further explore the molecular mechanism underlying PLK1-induced PCa progression and resistance to therapy, we turned our eyes to epigenetic modifications. It has been documented that epigenetic deregulation such as histone modification and DNA methylation contributes to PCa initiation and progression. Enhancer of zeste homologue 2 (EZH2), the catalytic subunit of Polycomb-repressive complex 2 (PRC2), plays a critical role in repressing gene expression by tri-methylation of histone 3 at lysine 27 (H3K27me3). Emerging data have demonstrated that there is a link between EZH2 and oncogenesis as EZH2-mediated methylation acts as an important factor in epigenetic silencing of tumor suppressor genes in cancer. Expression of EZH2 is often upregulated in castration-resistant prestate cancer (CRPC), thus EZH2 has been proposed as a target for CRPC. Importantly, it has been demonstrated that EZH2 becomes hyperphosphorylated in CPRC cells. Further, it has been shown that the oncogenic function of EZH2 is usually regulated by the post-translational modifications. PLK1 acting as a serine/threonine kinase to regulate multiple signaling pathways in human cancer, however, whether PLK1 is involved in EZH2 phosphorylation is not known. Herein, we show that Plk1 physically interacts with EZH2 and negatively regulates H3K27 trimethylation (H3K27me3). Furthermore, Plk1 can phosphorylate EZH2 at T144, and Plk1-mediated phosphorylation of EZH2 is involved in inhibiting EZH2 activity toward H3K27me3. More importantly, EZH2 phosphorylation by Plk1 is inhibitory for PRC2-mediated gene repression but required for transcriptional activation toward oncogenesis. Finally, by combination with Plk1 inhibitor BI2536, we show a robust sensitization of EZH2 inhibitors in CRPC cell lines, as well as in CRPC xenograft tumors. Our findings provide a new mechanism to define the oncogenic activity of EZH2 and suggest that inhibition of Plk1-mediated EZH2 activity may provide a promising therapeutic approach for CRPC.
(9525857), Fabiola Muro Villanueva. "Re-routing the phenylpropanoid pathway and its implications on plant growth". Thesis, 2020.
Znajdź pełny tekst źródłaThe phenylpropanoid pathway gives rise to a wide variety of specialized metabolites, but the majority of carbon flux going through this pathway is directed towards the synthesis of the lignin monomers: p-coumaryl alcohol, coniferyl alcohol and sinapyl alcohol. Lignin is a major impediment in biomass saccharification, which negatively affects animal feed and biofuel production. In an effort to improve biomass for the latter purposes, researchers have altered the polymer through genetic manipulations and generated biomass with lower recalcitrance to saccharification; however, in many cases these efforts have resulted in plant dwarfism. To date, we do not have a full understanding of the extent of lignin modifications a plant is able to tolerate without affecting its growth. More importantly, the mechanism that links dwarfism and modifications in lignin content and composition remains unknown. To contribute to answering these questions, we designed a strategy to incorporate a novel monomer into the lignin of Arabidopsis thaliana. We used mutants in genes that code for enzymes and regulators of the phenylpropanoid pathway to redirect the pathway’s flux towards the synthesis of p-coumaraldehyde and prevent the incorporation of p-coumaryl alcohol. Despite being mutated for the genes typically considered to be required for monolignol biosynthesis, the plants we generated continue to incorporate p-coumaryl alcohol into their lignin. This result suggests that the pathway’s architecture has not been completely elucidated and that there are more enzymes involved in lignification than previously thought. Additionally, we explored the connection between perturbations in phenylpropanoid metabolism and plant growth, by using an inducible system to track the changes in gene expression and metabolism that occur when phenylpropanoid metabolism is restored in a lignin biosynthetic mutant. The use of an inducible system allowed us to not only determine the metabolic processes affected in this mutant, but the proximal sequence of events that lead to restored growth when a functional copy of the mutant gene is induced. Finally, we redirected the flux through the pathway to assess the effects of simultaneously modulating lignin content and composition. Through this project we discovered that redirecting phenylpropanoid flux towards the synthesis of sinapyl alcohol in lignin-deficient mutant backgrounds, results in plant dwarfism. The growth impairment of these mutants can be overcome by providing exogenous coniferyl alcohol, suggesting that dwarfism in these mutants is caused by deficiency in coniferyl alcohol and/or derivatives thereof and not lignin alone. Altogether these projects allowed us to define the cellular processes affected by perturbations in phenylpropanoid homeostasis and the role of other phenylpropanoids besides lignin in this process.
(8086712), Lee M. Stunkard. "UNVEILING ENZYMATIC MECHANISMS WITH MALONYL-THIOESTER ISOSTERES". Thesis, 2019.
Znajdź pełny tekst źródła(8801354), Monica Leigh Husby. "Mechanisms of deadly and infectious viruses: Learning how lipid enveloped viruses assemble". Thesis, 2020.
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