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Rozprawy doktorskie na temat „Bile”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Zhu, Xiao Xia. "Binding interactions of bile acids and bile pigments with amines." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75846.

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The binding of selected bile acids and bile pigments by peptides and quaternary amines has been studied by adsorption and NMR experiments. Novel adsorbents with quaternized peptide-containing functional groups for bile acids have been prepared by solid phase peptide synthesis techniques. The adsorption studies, conducted in aqueous buffer solutions, show that these resins have an enhanced capacity, on a per active site basis, and improved specificity over cholestyramine and colestipol. The interaction between bile acid anions and the pendants is predominantly ionic linkage, although hydrophobi

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2

Trusova, Tatyana. "Quantitative estimation of bile acid conjugates in human bile using HPLC /." Connect to online version, 1995. http://hdl.handle.net/1989/3555.

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3

Benson, Gregory Martin. "Studies on bile acid sequestrants and bile acid metabolism in the hamster." Thesis, Royal Veterinary College (University of London), 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518089.

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4

Li, Hai. "Bile acids enterohepatic circulation." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2005. http://dare.uva.nl/document/77982.

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5

Hammond, Timothy G. "Hepatotoxicity of bile salts." Thesis, University of Birmingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496893.

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6

Torchia, Enrique C. "The role of intracellular bile acid binding proteins in bile acid transport and cytoprotection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ60354.pdf.

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7

Näf, Gabriela. "Viscosity of human bile from the common bile duct sampled during endoscopic retrograde cholangiography /." [S.l.] : [s.n.], 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000277045.

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8

Adolfsson-Erici, Margaretha. "Fish bile in environmental analysis." Doctoral thesis, Stockholm : Department of Applied Environmental Science, Stockholm University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-494.

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9

Rao, Girish. "Enzyme electrode studies of bile acids." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/11881.

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10

Crowley, Cara Leilani. "Bile salt induced stress response pathways." Diss., The University of Arizona, 2000. http://hdl.handle.net/10150/289231.

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Our lab has shown that the bile salt found in the highest concentration in human fecal water, sodium deoxycholate, induces apoptosis in several cell types including Jurkat cells as well as human colonic epithelial cells. We have also found that cells within the normal appearing flat mucosa of patients with a history of colon cancer are relatively resistant to apoptosis induced by NaDOC. The current studies test the hypothesis that sodium deoxycholate induces multiple stress response pathway s that protect against apoptosis. I have tested this hypothesis by developing and analyzing cell lines t

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11

Qian, Jiang. "Studies of Sulfur Reduction of Taurine and Taurine-Conjugated Bile Acids by Bile acid 7α-Dehydroxylating Bacteria". TopSCHOLAR®, 2000. http://digitalcommons.wku.edu/theses/694.

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Bile acids are C24 steroids that are derived in the liver from cholesterol and secreted into the intestinal lumen to aid in emulsification of dietary lipids and lipid-soluble vitamins. The indigenous intestinal microflora modify bile acids, producing up to 20 unique bile acid metabolites. The 7α-dehydroxylation of the bile acids is the most physiologically important bile acid biotransformation. All known intestinal bacteria capable of bile acid 7α-dehydroxylation are anaerobic, gram-positive rods of the genera Clostridium and Eubcicterium. Bile acid 7α-dehydroxylating bacteria often contain bi

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12

Chaby, Lara Santos Coelho Joana. "Biliary excretion of technetium-99m-sestamibi in wild-type dogs and in dogs with intrinsic (ABCB1-1[delta] mutation) extrinsic (ketoconazole treated) P-glycoprotein defiency." Online access for everyone, 2008. http://www.dissertations.wsu.edu/Thesis/Summer2008/j_coelho_071508.pdf.

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13

Wu, Gaoming. "Adsorption of bile salts by multifunctional resins." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70362.

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Ammonium-containing polyacrylamide resins, ammonium-containing polystyrene resins, and their metal-ion coordinated analogs have been synthesized for the sorption of bile salts (BS). The effects of altering the backbone, the type of ammonium group, the number of ammonium group, the hydrophobicity of the pendant group, and of varying the metal ions on the adsorption of BS's, were studied to elucidate the structure-activity relationship.<br>The binding capacity of the resins for BS's generally increased with increasing number of ammonium groups per pendant group of the ammonium-bearing resins, an

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14

Heer, Jasdip Singh. "The interaction of bile salts with mucins." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283207.

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15

Souto, Fhoutine Marie Reis. "Bile negra: terrorismo, câncer e seus combates." Pontifícia Universidade Católica de São Paulo, 2015. http://tede2.pucsp.br/handle/handle/2526.

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Made available in DSpace on 2016-04-25T20:21:22Z (GMT). No. of bitstreams: 1 Fhoutine Marie Reis Souto.pdf: 974083 bytes, checksum: ab742073e878f7eb4d7cf381d4f4a311 (MD5) Previous issue date: 2015-03-27<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>This work takes as a base the hypothesis that terrorism has been fought throughout history by the nations in a way akin to how Western medicine fights cancer, that unpredictable and unbearable disease that still has no definitive cure. Since its emergence in the end of the 19th century, terrorism this being the definition g

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16

Stelmakh, G. Ya. "The physiological atresia of common bile duct." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18460.

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17

Zheng, Zhi-Ying 1957. "Bile acid-induced DNA damage in bacteria." Thesis, The University of Arizona, 1990. http://hdl.handle.net/10150/291421.

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Bile acids have been implicated by epidemiologic evidence as causative agents in colon cancer. Previous studies have indicated that the bile acids damage DNA. However, the conjugated forms of bile acids (eg. tauro conjugates) have not been tested for interaction with DNA. The present study compared the DNA-damaging ability of unconjugated and conjugated bile acids using the E. coli SOS test system. The E. coli tester strain was incubated with the bile acids and conjugated bile acids. Both cell survival and induction of the SOS response was measured. Among unconjugated bile acids, deoxycholate,

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18

McNeilly, Alison Delamere. "The impact of bile acids on glucocorticoid metabolism." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/24968.

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The work in this thesis demonstrates that bile acids and their conjugates are competitive inhibitors of glucocorticoid metabolism by both 11β-HSD1 and 5β-reductase in liver. In vivo, in male Wistar rats, manipulation of hepatic bile acid concentrations by dietary supplementation with chenodeoxycholic acid (CDCA; 1% w/w) suppressed activities of hepatic 5β-reductase and 11βHSD1 activity and caused a reduction in total urinary (mainly 5β-reduced) glucocorticoid metabolites. In response to acute restraint stress bile acid treated animals showed a delay in return to basal corticosterone levels ind

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19

Kiroff, George Kosta. "Oesophageal mucosal injury by acid and bile salt /." Title page, table of contents and summary only, 1986. http://web4.library.adelaide.edu.au/theses/09MS/09msk59.pdf.

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Thesis (M.S.)--University of Adelaide, Dept. of Surgery, 1989.<br>The experimental work described was performed in the Department of Surgery of the University of Adelaide during 1982-1983. Typescript (photocopy). Includes bibliographical references (leaves 191-211).

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20

Bajor, Antal. "Bile acid induced diarrhoea : pathophysiological and clinical aspects /." Göteborg : Dept. of Internal Medicine, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, 2008. http://hdl.handle.net/2077/9840.

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21

Leonard, Danièle. "Adsorption of bile acids by ion-exchange resins." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74309.

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The interactions of cholestyramine with bile acids in aqueous buffer solutions were studied by in vitro adsorption experiments. Application of the Donnan theory, which is based on ion partitioning between two phases, indicates that the adsorption is an ion-exchange process--the bile acid anion displaces the chloride counter-ion of cholestyramine. Donnan considerations indicate that the bile acid in the resin phase exists in two forms, bound and unbound, but at higher Ceq the bound form is increasingly favoured. Since the concentrations of bound bile acid in the resin phase are above the critic

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22

Pattni, Sanjeev. "Mechanisms of idiopathic bile acid malabsorption and diarrhoea." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11109.

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Bile acid malabsorption or diarrhea (BAM or BAD) is a syndrome of chronic watery diarrhoea diagnosed predominantly by a SeHCAT test and less commonly by measuring levels of 7-hydroxy-4-cholesten-3-one (C4) and furthermore responds to bile acid sequestrants (BAS). Primary bile acid diarrhoea (PBAD) is the condition with no definitive cause and is under diagnosed, often being labelled as IBS-diarrhoea with an associated burden of disease for patients. Recently an alternative mechanism for PBAD involving impaired Fibroblast Growth Factor (FGF19) production has been proposed. Aims: The primary aim

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23

PULEO, Gianluigi. "Synthesis and use of bile acid derived organocatalysts." Doctoral thesis, Scuola Normale Superiore, 2009. http://hdl.handle.net/11384/85788.

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The central idea of this work was design, synthesis and study of catalytic activity and enantioselectivity of new organocatalysts containing a chiral cavity mimicking the enzymatic pocket of Aldolase I. Following the longstanding interest of our research group in the use of bile acid derivatives in enantioselective processes, attention was addressed to the development of organocatalysts having bile acid structure, where, because of its concave structure, due to the cis junction of the A and B cyclohexanic rings (Figure 3), the cholestanic backbone and the appended substituents should form a ch

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24

D'Souza, Lawrence Joseph. "Bile Acid Based Molecular Tweezers And Crown Ethers." Thesis, Indian Institute of Science, 1995. https://etd.iisc.ac.in/handle/2005/114.

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Chapter 1. Introduction to Molecular Tweezers Whitlock and Zimmerman developed a class of molecular hosts, popularly known as molecular tweezers, which sandwich aromatic guests by ii=ii interaction. Chapter 1 summarizes molecular tweezers of various kinds which have recently been synthesized. Chapter 2. Design and synthesis of "Bile Acid-Based Molecular Tweezers" Bile acids have a rigid backbone, and the array of hydroxyl groups separated by 5-7 A provides opportunities for the attachment of binding surfaces such as two extended chromophoric units.

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25

D'Souza, Lawrence Joseph. "Bile Acid Based Molecular Tweezers And Crown Ethers." Thesis, Indian Institute of Science, 1995. http://hdl.handle.net/2005/114.

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Chapter 1. Introduction to Molecular Tweezers Whitlock and Zimmerman developed a class of molecular hosts, popularly known as molecular tweezers, which sandwich aromatic guests by ii=ii interaction. Chapter 1 summarizes molecular tweezers of various kinds which have recently been synthesized. Chapter 2. Design and synthesis of "Bile Acid-Based Molecular Tweezers" Bile acids have a rigid backbone, and the array of hydroxyl groups separated by 5-7 A provides opportunities for the attachment of binding surfaces such as two extended chromophoric units.

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26

Lundåsen, Thomas. "Studies on the hormonal regulation of bile acid synthesis /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-053-4/.

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27

Geenes, Victoria Louise. "Placental bile acid homeostasis in norma and pathological pregnancy." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.508943.

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28

Jolly, Arthur James. "The role of acid and bile in oesophageal carcinogenesis." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436434.

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29

Ooi, Renn Chan. "The flow of bile in the human cystic duct." Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420838.

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30

Barker, Gillian M. "Bile acids and neutral sterols in familial adenomatous polyposis." Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308002.

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In familial adenomatous polyposis (FAP), inactivation of the APC gene is directly linked to the development of gastrointestinal polyps and cancer. It is likely that other epigenetic factors are involved in the malignant change of polyp to carcinoma. Previous studies have implied an abnormal bile acid profile, both in faeces and bile. In this study, using carefully matched control groups, extraction of bile acids from faeces and bile was performed and analysis was rigorously performed using Gas-liquid chromatography-Mass Spectrometry. No significant differences were found between the two groups

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31

Byrne, Jane Alexandra. "Functional characterisation of the human bile salt export pump." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408752.

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32

Schultz, Francisca. "Bile acid signalling in the fetal heart and myometrium." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58279.

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Intrahepatic Cholestasis of Pregnancy (ICP) is a liver disease that affects approximately 1% pregnancies in the United Kingdom. ICP is characterised by an increase in maternal serum bile acids (BA), as well as a change in bile acid composition, whereby the increase in primary bile acids, taurocholic acid (TC) and taurochenodeoxycholic acid (TCDCA) is most pronounced. ICP is characterised by maternal symptoms and can be complicated by adverse events for the fetus, the latter of which occur more commonly in pregnancies complicated by high maternal serum bile acid levels. Adverse events that may

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33

Opiyo, Monica Naomi. "The role of glucocorticoid metabolism in bile acid homeostasis." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25673.

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Alterations in glucocorticoid (GC) biosynthesis and metabolism are associated with a variety of pathophysiological disorders including cholestasis, diabetes and other metabolic disorders. Bile acids (BA) are also important modulators of metabolic functions and regulate cholesterol, triglyceride and glucose homeostasis as well as being critical for dietary fat digestion, enterohepatic function, and postprandial thermogenesis. In intact cells and in vivo, the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts inactive GC precursors (cortisone in humans, and 11-dehydrocorticostero

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34

Watts, Joseph. "The synthesis of A-ring fluorinated bile acid analogues." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/410301/.

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Bile acids are physiological detergent molecules with a function to absorb dietary lipids and hydrophobic molecules in the gastrointestinal tract. It has emerged that bile acids are also agonists for the FXR nuclear receptor and the TGR5 membrane-bound receptor, and are key in regulating metabolism via both genomic and non-genomic factors. It is also apparent that bile acids could play an important role in the treatment of Parkinson’s disease and some cancers. A number of pharmaceutical companies have developed selective BA receptor agonists, with some progressing through clinical trials for a

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35

Antoniuk, O. P. "Formation of physiological atresia in embryogenesis of bile ducts." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19313.

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36

li, qingjiang. "Chemical investigations into the physiology of bile acid skeletons." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1354810854.

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37

Badiee, Mohsen. "Mechanistic Insights intoThe Physiology of Bile acids and Retinoids." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1505919467280191.

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38

Nguyen, Elizabeth Ann Gaddi. "The Regulation of Bile Acids on NHE8 Gene Expression." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/297714.

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Sodium is an essential electrolyte necessary to keep multiple systems in the human body functional. Knowledge of sodium-proton exchanger will give rise to multiple clinical applications to diseases that affect our current population, which is why I personally am interested in conducting research in this field. In order to understand GW 4064 effect on NHE8 gene expression, protein and RNA expression were investigated via treatment at different concentrations and different time intervals through Western blotting and Real-Time PCR Analysis. To find the mechanism behind GW 4064 effects on NHE 8 ex

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39

Zeck, Lisa. "Optimization of an immobilized enzyme system for conjugated bile acids /." Connect to online version, 1995. http://hdl.handle.net/1989/3548.

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40

Li, Tiangang. "PREGNANE X RECEPTOR REGULATION OF BILE ACID METABOLISM AND CHOLESTEROL HOMEOSTASIS." Kent State University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=kent1132160196.

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41

Werry, Brian Scott. "Characterizing Bile Acid Association as a Ligand and in Micellization." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1386186690.

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42

Ellis, Ewa C. S. "Use of primary human hepatocytes for elucidation of bile acid synthesis /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-424-0.

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43

Chignard, Nicolas. "Bile Salts and Nuclear Receptors in Biliary Epithelial Cell Pathophysiology." Habilitation à diriger des recherches, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00726374.

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The biliary epithelium is organized as a single layer of biliary epithelial cells (BECs) lining the biliary tree. BECs have three major biological functions: protection, secretion and proliferation. These functions may all be controlled by bile salts, the main constituents of bile. We therefore determined if human gallbladder-derived BECs exhibited bile salt transport activities that affect their secretory functions. We could show that the apical bile acid sodium- dependent transporter (ASBT) is expressed and functional in primary cultures of human BECs. Once transported inside BECs, bile salt

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44

Donnellan, Clare Fiona. "Gene expression in oesophageal cells following acid and bile exposure." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432643.

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45

Cleverly, Douglas Robert. "Bile salt-stimulated human milk lipase characterisation and kinetic studies." Thesis, University of Auckland, 1992. http://hdl.handle.net/2292/2329.

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Chapter One begins with an introduction to enzymology and leads into a discussion on BSSL beginning with the physical properties and the source of the enzyme. The literature concerning the kinetic properties of BSSL is reviewed, followed by a discussion on how the structure of enzymes influences their catalytic activity and specificity. The use of X-ray crystallographic techniques is addressed as a means of elucidating the three dimensional structure of enzymes. The chemicals, apparatus and standard methodologies used in this present investigation are described in Chapter Two. The means by whi

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46

Murphy, Charlotte. "Studies on the regulatory roles of cholesterol and bile acids /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-173-9/.

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47

Whittaker, Martin. "Competitive binding of bile salts with ammonium-bearing polystyrene resins." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56684.

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Previous in vitro binding studies for bile acids by polymeric ion-exchange resins indicate that the binding process involves three types of interaction; a predominant electrostatic interaction, a secondary hydrophobic interaction and a seemingly less important hydrogen bonding effect. To further investigate the nature of the sorption process, a family of ammonium-bearing polystyrene resins have been synthesized for the in vitro sorption of bile acid anions. A correlation was made between the structure of the resin pendant group and sorption efficiency. The extent to which the binding process i

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48

Fitzpatrick, W. J. F. "Intrajejunal bile acid precipitation in health and following ileal resection." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599061.

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49

McKillop, Aine M. "Molecular forms of bile salt stimulated lipase in human milk." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337108.

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50

Hurley, J. P. "Novel bile acid-hydrogel systems as potential nedical device biomaterials." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269055.

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