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Rozprawy doktorskie na temat „Bile Acids”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Li, Hai. "Bile acids enterohepatic circulation." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2005. http://dare.uva.nl/document/77982.

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2

Zhu, Xiao Xia. "Binding interactions of bile acids and bile pigments with amines." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75846.

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The binding of selected bile acids and bile pigments by peptides and quaternary amines has been studied by adsorption and NMR experiments. Novel adsorbents with quaternized peptide-containing functional groups for bile acids have been prepared by solid phase peptide synthesis techniques. The adsorption studies, conducted in aqueous buffer solutions, show that these resins have an enhanced capacity, on a per active site basis, and improved specificity over cholestyramine and colestipol. The interaction between bile acid anions and the pendants is predominantly ionic linkage, although hydrophobi

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3

Rao, Girish. "Enzyme electrode studies of bile acids." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/11881.

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4

Bradburn, David Michael. "Bile acids and short fatty acids in familial adenomatous polyposis." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308760.

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5

Trusova, Tatyana. "Quantitative estimation of bile acid conjugates in human bile using HPLC /." Connect to online version, 1995. http://hdl.handle.net/1989/3555.

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6

Qian, Jiang. "Studies of Sulfur Reduction of Taurine and Taurine-Conjugated Bile Acids by Bile acid 7α-Dehydroxylating Bacteria". TopSCHOLAR®, 2000. http://digitalcommons.wku.edu/theses/694.

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Bile acids are C24 steroids that are derived in the liver from cholesterol and secreted into the intestinal lumen to aid in emulsification of dietary lipids and lipid-soluble vitamins. The indigenous intestinal microflora modify bile acids, producing up to 20 unique bile acid metabolites. The 7α-dehydroxylation of the bile acids is the most physiologically important bile acid biotransformation. All known intestinal bacteria capable of bile acid 7α-dehydroxylation are anaerobic, gram-positive rods of the genera Clostridium and Eubcicterium. Bile acid 7α-dehydroxylating bacteria often contain bi

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7

McNeilly, Alison Delamere. "The impact of bile acids on glucocorticoid metabolism." Thesis, University of Edinburgh, 2006. http://hdl.handle.net/1842/24968.

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The work in this thesis demonstrates that bile acids and their conjugates are competitive inhibitors of glucocorticoid metabolism by both 11β-HSD1 and 5β-reductase in liver. In vivo, in male Wistar rats, manipulation of hepatic bile acid concentrations by dietary supplementation with chenodeoxycholic acid (CDCA; 1% w/w) suppressed activities of hepatic 5β-reductase and 11βHSD1 activity and caused a reduction in total urinary (mainly 5β-reduced) glucocorticoid metabolites. In response to acute restraint stress bile acid treated animals showed a delay in return to basal corticosterone levels ind

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8

Leonard, Danièle. "Adsorption of bile acids by ion-exchange resins." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74309.

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The interactions of cholestyramine with bile acids in aqueous buffer solutions were studied by in vitro adsorption experiments. Application of the Donnan theory, which is based on ion partitioning between two phases, indicates that the adsorption is an ion-exchange process--the bile acid anion displaces the chloride counter-ion of cholestyramine. Donnan considerations indicate that the bile acid in the resin phase exists in two forms, bound and unbound, but at higher Ceq the bound form is increasingly favoured. Since the concentrations of bound bile acid in the resin phase are above the critic

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9

Zeck, Lisa. "Optimization of an immobilized enzyme system for conjugated bile acids /." Connect to online version, 1995. http://hdl.handle.net/1989/3548.

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10

Barker, Gillian M. "Bile acids and neutral sterols in familial adenomatous polyposis." Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308002.

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In familial adenomatous polyposis (FAP), inactivation of the APC gene is directly linked to the development of gastrointestinal polyps and cancer. It is likely that other epigenetic factors are involved in the malignant change of polyp to carcinoma. Previous studies have implied an abnormal bile acid profile, both in faeces and bile. In this study, using carefully matched control groups, extraction of bile acids from faeces and bile was performed and analysis was rigorously performed using Gas-liquid chromatography-Mass Spectrometry. No significant differences were found between the two groups

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11

Badiee, Mohsen. "Mechanistic Insights intoThe Physiology of Bile acids and Retinoids." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1505919467280191.

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12

Nguyen, Elizabeth Ann Gaddi. "The Regulation of Bile Acids on NHE8 Gene Expression." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/297714.

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Sodium is an essential electrolyte necessary to keep multiple systems in the human body functional. Knowledge of sodium-proton exchanger will give rise to multiple clinical applications to diseases that affect our current population, which is why I personally am interested in conducting research in this field. In order to understand GW 4064 effect on NHE8 gene expression, protein and RNA expression were investigated via treatment at different concentrations and different time intervals through Western blotting and Real-Time PCR Analysis. To find the mechanism behind GW 4064 effects on NHE 8 ex

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13

Ellis, Ewa C. S. "Use of primary human hepatocytes for elucidation of bile acid synthesis /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-424-0.

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14

Bajor, Antal. "Bile acid induced diarrhoea : pathophysiological and clinical aspects /." Göteborg : Dept. of Internal Medicine, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, 2008. http://hdl.handle.net/2077/9840.

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15

Murphy, Charlotte. "Studies on the regulatory roles of cholesterol and bile acids /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-173-9/.

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16

Kehring, Allysa. "Bile Acids to Predict the Developments of Neonatal Necrotizing Enterocolitis." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146074.

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This honors thesis analyzes the methodology and results of ongoing research on the potential use of bile acid concentrations in neonatal stool to be used as an indicator for the onset of the disease necrotizing enterocolitis (NEC). NEC is a serious complication in a premature infant with the potential for death. Twenty-two patients were enrolled in the study over the period of eight months, however, no patient developed NEC. Control patients were analyzed for trends in bile acid concentrations. Elevation of in bile acid concentration were seen following each feeding. Previous inclinations were

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17

Tierney, Juliann Jude. "The synthesis and testing of novel cholic acid based stationary phases." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247854.

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18

Jean-Louis, Samira. "Membrane Perturbation By Bile Acids and Their Potential Role in Signaling." Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1471%5F1%5Fm.pdf&type=application/pdf.

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19

Lowe, Gordan M. "Biochemical and genetic aspects of the microbial degradation of bile acids." Thesis, Liverpool John Moores University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305858.

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20

Obuseng, Veronica Conie. "Bile acids as indicator of faecal inputs into soils and sediments." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391155.

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21

Elhmmali, Mohamed Mimoun. "Complementary use of bile acids and sterols as sewage pollution indicators." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245524.

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22

Jean-Louis, Samira. "Membrane Perturbation By Bile Acids and Their Potential Role in Signaling." Diss., The University of Arizona, 2005. http://hdl.handle.net/10150/193551.

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Secondary bile acids have long been postulated to be tumor promoters in the colon but their mechanism of action are yet to be delineated. Though most bile acids are chemically similar, they have been found to exert contrasting signaling effects in the colonic epithelium. Particularly, hydrophobic bile acids such as deoxycholic acid (DCA) are found to be tumor promoters while their hydrophilic counterparts such as ursodeoxycholic acid (UDCA) are chemopreventive. Given the fact that colon cells do not possess bile acid transporters, the question that arises is how do bile acids activate intra

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23

Opiyo, Monica Naomi. "The role of glucocorticoid metabolism in bile acid homeostasis." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25673.

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Alterations in glucocorticoid (GC) biosynthesis and metabolism are associated with a variety of pathophysiological disorders including cholestasis, diabetes and other metabolic disorders. Bile acids (BA) are also important modulators of metabolic functions and regulate cholesterol, triglyceride and glucose homeostasis as well as being critical for dietary fat digestion, enterohepatic function, and postprandial thermogenesis. In intact cells and in vivo, the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts inactive GC precursors (cortisone in humans, and 11-dehydrocorticostero

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24

Werry, Brian Scott. "Characterizing Bile Acid Association as a Ligand and in Micellization." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1386186690.

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25

Harris, Spencer. "Discovery and characterization of bile acid and steroid metabolism pathways in gut-associated microbes." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4713.

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The human gut microbiome is a complex microbial ecosystem residing in the lumen of our gastrointestinal tract. The type and amounts of microbes present in this ecosystem varies based on numerous factors, including host genetics, diet, and environmental factors. The human gut microbiome plays an important role in normal host physiological functions, including providing energy to colonocytes in the form of short-chain fatty acids. However, gut microbial metabolites have also been associated with numerous disease states. Current tools for analyzing the gut microbiome, such as high-throughput sequ

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26

Chen, Fei Wen. "Lean NAFLD: A distinct entity shaped by differential metabolic adaptation." Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/22240.

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Non-alcoholic fatty liver disease (NAFLD) prevalence is growing dramatically with epidemic of obesity. A subset of patients with NAFLD is lean, but the pathophysiology of this sub-group is still not well known. This project aims to investigate the roles of metabolic health and metabolic adaptation in the pathogenesis of lean NAFLD, using well-characterised Caucasian subjects with lean and non-lean NAFLD, and comparing them with the lean and non-lean healthy controls, and murine models. We investigated in detail their demographics, genetic background, bile acid profile, gut microbiota and thei

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27

Choucair, Ibrahim. "GUT MICROBE METABOLISM OF BILE ACIDS AND THEIR RELATIONSHIP TO CARDIOMETABOLIC DISEASES." Cleveland State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=csu1570190994304441.

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28

Milona, Alexandra. "Role of FXR in the adaptive response to bile acids during pregnancy." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/4727.

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The bile acid receptor FXR maintains bile acid homeostasis through the dynamic regulation of transporters, detoxification and biosynthesis enzymes. Intrahepatic cholestasis of pregnancy (ICP) is caused by disturbance in bile acid homeostasis in predisposed individuals. The first genetic variants in FXR, identified in an ICP population, are investigated in this thesis using in vitro approaches and a functional effect is demonstrated. Reproductive hormones are implicated in the aetiology of ICP but experiments in mice suggest that estrogen and progesterone alone are unlikely to be the cause of g

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29

Mooranian, Armin. "Novel artificial cell microencapsulation of probucol and bile acids in diabetes mellitus." Thesis, Curtin University, 2018. http://hdl.handle.net/20.500.11937/70687.

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This thesis studied bile acids in the oral delivery of the anti-diabetic compound probucol as therapy for diabetes mellitus and in the application of microencapsulation of pancreatic β- cells. Bile acids improved the stability of the pharmaceutical formulation system containing probucol and enhanced the oral delivery resulting in greater bioavailability, tissue concentrations and glucose lowering effects in diabetic animals. Bile acids also improved the viability and activity of pancreatic β-cells within microcapsules via cellular protective effects.

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30

ISHII, AKIRA, HIROSHI SENO, HIDEKI HATTORI, et al. "Simple and Rapid Quantitation of 21 Bile Acids in Rat Serum and Liver by UPLC-MS-MS: Effect of High Fat Diet on Glycine Conjugates of Rat Bile Acids." Nagoya University School of Medicine, 2013. http://hdl.handle.net/2237/17602.

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31

Morgan, Sherif. "The Bile Acid, Deoxycholic Acid, Modulates IGF-IR Function in Colon Cancer Cells." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194122.

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Deoxycholic acid (DCA) is a secondary bile acid postulated to be involved in the etiology and the progression of colorectal cancer, but its specific mechanisms are not fully understood. DCA has been shown to induce apoptosis allowing selection for apoptosis-resistant cells, which highlights the importance of understanding the mechanisms of action of DCA. Previously, it has been demonstrated that DCA perturbs the plasma membrane, leading to the activation of receptor tyrosine kinases. Because the insulin-like growth factor-1 receptor (IGF-IR), a receptor tyrosine kinase, is demonstrated to pl

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32

Gälman, Cecilia. "Modulation of bile acid and cholesterol metabolism in health and disease /." Stockholm ; Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-7349-948-x.

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33

PULEO, Gianluigi. "Synthesis and use of bile acid derived organocatalysts." Doctoral thesis, Scuola Normale Superiore, 2009. http://hdl.handle.net/11384/85788.

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The central idea of this work was design, synthesis and study of catalytic activity and enantioselectivity of new organocatalysts containing a chiral cavity mimicking the enzymatic pocket of Aldolase I. Following the longstanding interest of our research group in the use of bile acid derivatives in enantioselective processes, attention was addressed to the development of organocatalysts having bile acid structure, where, because of its concave structure, due to the cis junction of the A and B cyclohexanic rings (Figure 3), the cholestanic backbone and the appended substituents should form a ch

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34

Cheah, Peh Yean. "The DNA-damaging effect of bile acids and the protective effect of cellulose." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184639.

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Colon cancer is the second most common type of cancer in the United States. Its incidence is linked epidemiologically to high levels of bile acids in the feces. Bile acids have been implicated as promotors and cocarcinogens in the etiology of colon cancer and as comutagens and mutagens in bacteria. These observations suggest the hypothesis that bile acids may interact directly with DNA. Using agarose gel electrophoresis we showed that bile acids convert covalently closed circular plasmid DNA to the open circular form, indicating strand breakage. We next treated the single stranded circular DNA

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35

Glinghammar, Björn. "Toxicological aspects of bile acids and human fecal water on cultered human colon carcinoma cells /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4816-x/.

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36

Münch, Andreas. "Collagenous colitis : The influence of inflammation and bile acids on intestinal barrier function." Doctoral thesis, Linköpings universitet, Gastroenterologi och hepatologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-56291.

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Background and aims: Collagenous colitis (CC) is a diarrheal disorder with an incidence rate of 5-6/100000 inhabitants, affecting mainly middle-aged women. The diagnosis is made by histology of the colonic mucosa. Classical findings are a thickened subepithelial collagenous layer and chronic inflammation in the lamina propria. In inflammatory bowel disease (IBD) the mucosal barrier function is important in pathogenesis. The main purpose of the thesis was therefore to describe the barrier function in CC. The cause of CC is uncertain but the condition seems to be associated with bile acid malabs

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37

Speight, Richard Alexander. "The role of bile acids and farnesoid X receptor in ileal Crohn's disease." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/3078.

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The aetiopathogenesis of Crohn’s disease (CD) is characterised by epithelial barrier dysfunction and immune dysregulation in a genetically susceptible host. Exposure to a western diet, a dysbiosis and bile acid (BA) dysmetabolism have also been implicated. The BA receptor, farnesoid-x receptor (FXR), is central to the crosstalk between the host and its microbiota. FXR acts to maintain the epithelial barrier and has an immuno-modulatory function although the mechanism is not fully understood. The first aim of this study was to investigate the effect of FXR agonism using invitro models of cytoki

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38

Zhang, Xuejun. "Branched and spiral organic nanotubes based on the self-assembly of bile acids." Master's thesis, University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4542.

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The fluorescent composite tubes can undergo pH switchable spiral/straight, which are a promising system for a variety of materials and biological applications.; The self-assembly of chiral amphiphilic molecules in aqueous solutions is of particular interest because the chirality of individual molecules is often expressed in their supermolecular structures. Self-assembled tubes made of chiral amphiphilic molecules represent useful supramolecular architectures which hold promise as controlled release vehicles for drug delivery, encapsulates for functional molecules, and nanoreactors for chemical

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39

Lundåsen, Thomas. "Studies on the hormonal regulation of bile acid synthesis /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-053-4/.

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Baxter, Debbie Jane. "Molecular mechanisms of biliary lipid secretion." Thesis, Liverpool John Moores University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298908.

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41

Delsol, Anne Aline Germaine. "Microbial 7-hydroxylation of the steroid lithocholic acid : a novel approach to produce bile acids for gallstone therapy." Thesis, University of Exeter, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297640.

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42

Castellanos, jankiewicz Ashley. "Bile acids signaling as a novel mechanism in the hypothalamic control of energy balance." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0218.

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Introduction : Les acides biliaires (AB) sont des molécules connues pour digérer les lipides. En activant le récepteur couplé à la protéine G Takeda 5 (TGR5) dans les tissus périphériques, ils peuvent également servir de molécules de signalisation pour réduire le poids corporel et améliorer le profil glycémique. L'activation de TGR5 peut aussi augmenter la dépense énergétique dans le tissu adipeux, mais les voies métaboliques impliquées dans ces effets sont encore mal connues. Ces observations impliquent une action anti-obésité du TGR5. Cependant, toutes les études sur les AB dans la balance é

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43

Kandell, Risa Lynne. "Bile acid-induced DNA damage and repair in bacterial and mammalian cells." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/184976.

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Colon cancer is the second most common type of cancer in the United States. Its incidence is linked epidemiologically to high levels of bile acids in the feces. Bile acids have been implicated as promoters and cocarcinogens in the etiology of colon cancer and as comutagens and mutagens in bacteria. These observations suggest the hypothesis that bile acids may damage DNA. By using the DNA-damage inducible SOS system in Escherichia coli, this study shows that when bacteria are exposed to bile acids there is induction of the SOS repair system and preferential survival of cells undergoing repair.

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44

Cheng, Jeffrey Binyan. "CDNA cloning and characterization of enzymes that synthesize bile acids, vitamin D and waxes." Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=150.

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45

Adebola, Oluwakemi. "The relationship between probiotics, prebiotics and bile acids and the impact on gut health." Thesis, University of East London, 2009. http://roar.uel.ac.uk/3196/.

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Epidemiological studies show a diet rich in fats and processed meats is often associated with higher levels of secondary bile acids and carcinogens in the gut and increases the risk of colorectal diseases. In recent years the consumption of probiotics and prebiotics has been widely proposed as a strategy to both prevent colorectal disease and generally improve gut health. The present study investigated the role of synbiotic applications of species of Lactobacilli (L. acidophilus NCFM LYO 10, L. acidophilus NCTC 1723, L. reuteri, L. brevis NCIMB 11973 and L. delbrueckii ss bulgaricus NCTC 12712

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46

Kaler, Balwant. "The role of bile acids in kidney failure as a result of obstructive jaundice." Thesis, University of East London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264409.

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47

Miró, Richart Paula. "Hydrogen-Abstraction, Energy Transfer and Exciplex Formation in Photoactive Systems Based on Bile Acids." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/64084.

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[EN] Bile acids are a family of amphiphilic steroids that play a pivotal role in physiological functions such as elimination of cholesterol or solubilization of lipids. Chemically, they share a steroidal skeleton with an unusual cis fusion between rings A and B, a short lateral chain ending in a carboxylic acid moiety and different number of hydroxyl groups on the alpha-face. Hence, bile acids offer a versatile architecture that can be used to investigate photophysical processes of interest such as hydrogen atom transfer, through-bond energy trasfer, through-bond exciplex formation and DNA ph

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48

Pournaras, Dimitrios. "Mechanisms maintaining reduced appetite and normoglycaemia after metabolic surgery : the role of bile acids." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/10201.

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Obesity is becoming the healthcare epidemic of this century. Weight loss surgery is the only effective treatment for morbid obesity. Furthermore glycaemic control in type 2 diabetic patients is improved after metabolic surgery. Here I observed that with gastric bypass, type 2 diabetes can be improved and even rapidly put into a state of remission irrespective of weight loss. This is achieved via an improvement of both insulin resistance and insulin production. Reduced insulin resistance within the first week after surgery remains unexplained, but increased insulin production in the first week

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49

Styles, Nathan Allen. "The characterization of the subcellular localization of bile acid CoA:N-acyltransferase." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007p/styles.pdf.

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50

Han, Shuxin. "Vitamin D receptor regulation of cholesterol 7[alpha]-hydroxylase gene transcription and bile acid synthesis in human hepatocytes." [Kent, Ohio] : Kent State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1257459841.

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