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Gotowa bibliografia na temat „Bern Trial”

Autor: Grafiati

Data publikacji: 28 lipca 2024

Data aktualizacji: 31 lipca 2024

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Artykuły w czasopismach na temat "Bern Trial"

Leddin, Desmond. "Alpha Errors, Beta Errors and Negative Trials". Canadian Journal of Gastroenterology 2, nr 4 (1988): 147–50. http://dx.doi.org/10.1155/1988/523841.

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Reports of negative trials arc increasing in number as standard therapy for many gastrointestinal diseases is refined. The validity of a negative report depends on the number of patients in the trial, the alpha and bern error and the difference in efficacy which the trial is able to detect. The relationship between these parameters is discussed and a formula given for the calculation of trial size. All reports of negative trials should include not only the number of patients involved and the level of significance of the results but also the beta error and the detectable difference in efficacy of the treatments.

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Hari, Roman, Kaspar Kälin, Michael Harris, Robin Walter i Andreas Serra. "Comparing Blended Learning with Faculty-Led Ultrasound Training: Protocol for a Randomised Controlled Trial (The SIGNATURE Trial)". Praxis 109, nr 8 (czerwiec 2020): 636–40. http://dx.doi.org/10.1024/1661-8157/a003497.

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Abstract. Background: Ultrasound is increasingly used in clinical practice as a bedside tool. As medical graduates first encounter the technique in early residency, ultrasound training needs to be integrated into the undergraduate curriculum. In Switzerland, abdominal ultrasound skills have been taught by a faculty-led, 21-hour course. However, this course does not have sufficient capacity to meet the increasing demand, and there have been doubts about its effectiveness as a teaching method. We therefore developed a 21-hour blended-learning course, comprising five hours of e-learning and 16 hours of near-peer tutoring. This study investigates whether this new teaching format is as good as, or superior to, the faculty-led method. Methods: The SIGNATURE study is an investigator-initiated, two-arm, randomised controlled trial, enrolling 152 medical students at the Universities of Bern, Fribourg and Zurich. Stratified by study site, students are 1:1 randomised to either the blended-learning course or the faculty-led 2.5-day ultrasound course. Students undergo a six-station objective structured clinical examination (OSCE) and complete an online questionnaire immediately after the course and 6 months later. Discussion: If demonstrated to be effective, the blended-learning course would allow an increase in the number of undergraduate medical students that can acquire ultrasound skills before starting their residencies.

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Riedel, Robert G. "Effects of Pretrial Publicity on Male and Female Jurors and Judges in a Mock Rape Trial". Psychological Reports 73, nr 3_part_1 (grudzień 1993): 819–32. http://dx.doi.org/10.1177/00332941930733pt117.

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A study explored influence of pretrial publicity and gender identity on verdicts and severity of sentence in a mock rape trial. Mock jurors and judges were exposed to four pretrial publicity conditions before watching a simulated rape trial. After viewing the trial, jurors rendered a verdict (guilty or not guilty) and judges prescribed a sentence. The Bern Sex-role Inventory was used to analyze gender identity and its relation to verdict and sentencing. Verdicts were not influenced by pretrial publicity, but sentencing was more severe following exposure of mock judges to pretrial publicity about a mistaken acquittal and less severe following exposure of these judges to pretrial publicity about a mistaken conviction. Subjects classified by the Bern inventory as feminine or androgynous rendered a verdict of “guilty” more often than subjects classified as masculine or undifferentiated. Men who rendered verdicts of “guilty” had less confidence in their judgments than men who found the defendant “not guilty.” Conversely, women who found the defendant “not guilty” expressed less confidence than women who found the defendant “guilty.” The findings are compared and contrasted with similar studies and discussed in regards to gender identity, subjects’ characteristics, and mode of presentation.

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Beilstein, Christian M., Gabija Krutkyte, Thomas Vetsch, Prisca Eser, Matthias Wilhelm, Zeno Stanga, Lia Bally i in. "Multimodal prehabilitation for major surgery in elderly patients to lower complications: protocol of a randomised, prospective, multicentre, multidisciplinary trial (PREHABIL Trial)". BMJ Open 13, nr 1 (styczeń 2023): e070253. http://dx.doi.org/10.1136/bmjopen-2022-070253.

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IntroductionThe global volume of surgery is growing and the population ageing, and economic pressure is rising. Major surgery is associated with relevant morbidity and mortality. Postoperative reduction in physiological and functional capacity is especially marked in the elderly, multimorbid patient with low fitness level, sarcopenia and malnutrition. Interventions aiming to optimise the patient prior to surgery (prehabilitation) may reduce postoperative complications and consequently reduce health costs.Methods and analysisThis is a multicentre, multidisciplinary, prospective, 2-arm parallel-group, randomised, controlled trial with blinded outcome assessment. Primary outcome is the Comprehensive Complications Index at 30 days. Within 3 years, we aim to include 2×233 patients with a proven fitness deficit undergoing major surgery to be randomised using a computer-generated random numbers and a minimisation technique. The study intervention consists of a structured, multimodal, multidisciplinary prehabilitation programme over 2–4 weeks addressing deficits in physical fitness and nutrition, diabetes control, correction of anaemia and smoking cessation versus standard of care.Ethics and disseminationThe PREHABIL trial has been approved by the responsible ethics committee (Kantonale Ethikkomission Bern, project ID 2020-01690). All participants provide written informed consent prior to participation. Participant recruitment began in February 2022 (10 and 8 patients analysed at time of submission), with anticipated completion in 2025. Publication of the results in peer-reviewed scientific journals are expected in late 2025.Trial registration numberNCT04461301.

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Amrein, Melanie Alexandra, Gian Giacomo Ruschetti, Carole Baeder, Melanie Bamert i Jennifer Inauen. "Mobile intervention to promote correct hand hygiene at key times to prevent COVID-19 in the Swiss adult general population: study protocol of a multiphase optimisation strategy". BMJ Open 12, nr 3 (marzec 2022): e055971. http://dx.doi.org/10.1136/bmjopen-2021-055971.

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IntroductionBehaviour change is key to the public health measures that have been issued in many countries worldwide to contain COVID-19. Public health measures will only take preventive effect if people adhere to them. Interventions taking health psychology approaches may promote adherence to public health measures. However, evidence from randomised controlled behaviour change trials is scarce during an ongoing pandemic. We aim to use the example of hand washing with soap to optimise and test a digital, theory-based and evidence-based behaviour change intervention to prevent the spread of COVID-19.Methods and analysisThis protocol describes the multiphase optimisation strategy for the preparation, optimisation and evaluation of a theory-based and evidence-based intervention delivered via app. The app aims to promote correct hand hygiene at key times in the adult general population. The study will be conducted in German-speaking Switzerland. The preparation phase has identified relevant behavioural determinants of hand hygiene during a pandemic from health behaviour theories and formative research with focus groups (n=8). The optimisation phase will identify the most effective and acceptable combination and sequence of three intervention modules in a parallel randomised trial (n=387) with analysis of variance (ANOVA) and regression analysis. Additionally, thematic analysis of qualitative interview data (n=15) will be used to gain insights on the feasibility, usability and satisfaction of the intervention. The evaluation phase will test the optimised intervention against an active control group in a randomised controlled trial (n=205), analysing pre-post differences and 6-month follow-up effects with ANOVA and regression analysis.Ethics and disseminationThe trial was approved by the Cantonal Ethics Commission Bern of the Swiss Association of Research Ethics Committees (protocol ID: 2021-00164). Final results will be presented in peer-reviewed journals and at conferences.Trial registration numberNCT04830761.

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Zwahlen, Susanne, Monica Fliedner i Steffen Eychmüller. "Overcoming recruitment challenges in a randomized clinical trial of early palliative care." Journal of Clinical Oncology 35, nr 31_suppl (1.11.2017): 140. http://dx.doi.org/10.1200/jco.2017.35.31_suppl.140.

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140 Background: Reasons why clinical trials of early palliative care (ePC) interventions have prolonged patient recruitment time frames have been researched mainly qualitatively. Our objective was to identify major recruitment barriers encountered in our ePC trial, as well as to implement actions to overcome them. The impact of these changes on recruitment was measured. Methods: Data from all patients screened at the main study site (Inselspital, University Hospital Bern) between October 2013 and April 2016 were prospectively analyzed for: date of contact, reporting department, eligibility status, as well as consent status. Data until march 2014 was used to identify the main recruitment barriers. Starting in march 2014 changes to the recruitment process were implemented and all data from then onwards was used to estimate the impact of these adaptations. Results: The three main barriers identified were: Logistic, motivational, or related to eligibility criteria. Logistic barriers were overcome by changing from voluntary referral by the treating physician to systematically screening outpatient clinics of medical oncology, radio-oncology, gyneco-oncology and the internal medicine ward. Motivational barriers were addressed through education and dedicated study staff. Eligibility criteria were widened to include pancreatic and urothelial cancer. The actions implemented increased the accrual rate from one patient during a five month period to 2,8 patients per month. The widening of the eligibility criteria contributed to this result by recruiting 0,5 patients per month. The implementation of a systematic screening procedure increased the number of eligible patients invited to participate from one per month to 4,8 per month. An increase in the study consent rate from 20 % to 58 % can be translated into an increased acceptance of early palliative care. Conclusions: Education and dedicated study staff in order to increase the acceptance of ePC as well as a tool to identify eligible patients in a time-efficient manner improved patient recruitment in our ePC trial. We suggest that these factors can be relevant for the successful integration of ePC in standard oncology care.

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Theis, Susanne, Norman Bitterlich, Michael von Wolff i Petra Stute. "Measuring Quality of Life: Incorporating Objectively Measurable Parameters within the Cross-Sectional Bern Cohort Study 2014 (BeCS-14)". International Journal of Environmental Research and Public Health 21, nr 1 (15.01.2024): 94. http://dx.doi.org/10.3390/ijerph21010094.

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Up until now, the measurement of Quality of Life (QoL) was based on validated subjective rating tools rather than objective measurement. To become more independent of the self-assessment of probands, a way to objectively measure QoL should be found. A monocenter, cross-sectional, observational, non-interventional trial was performed from 2012 to 2014 at Inselspital Bern to evaluate the bio-functional status (BFS), a complex, generic, non-invasive, sex- and age-validated assessment tool, in a wide range of areas. A standardized battery of assessments was performed on 464 females and 166 males, ages 18 to 65 (n = 630). In addition to the survey of the BFS, participants replied—among others—to the validated questionnaire SF-36 for health-related QoL (n = 447, subgroup 1). Since the accepted cut-off value for BFA calculation is age ≥ 35 years, subgroup 2 included 227 subjects (all participants aged ≥ 35 years out of subgroup 1). In order to be able to compare the eight SF-36 subscales to BFS parameters, a comparable score set of single BFS items had to be constructed. Subsequently, we aimed to statistically identify BFS item combinations that best represented each SF-36 subscale. All eight SF-36 subscales were significantly represented by various different combinations of BFS items. A total of 24 single BFS items significantly correlated with SF-36 subscales, of which 15 were objective and nine were subjective. All eight SF-36 subscales were significantly represented by various different combinations of BFS items leading to stronger correlations (range five to nine BFS items), and overall, sex and age did not affect these associations, but in the SF-36 subscales ‘bodily pain’ (sex) and ‘role limitations due to physical health problems’ (age in men). To our knowledge, we are the first to correlate a validated set of 34 objective and 9 subjective parameters with subjectively evaluated SF-36 subscales. This first study on the objectifiability of the SF-36 questionnaire demonstrated that questions on quality of life can be answered independently of a subjective assessment by subjects in future scientific studies.

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Liechti, Fabian D., Jeannelle Heinzmann, Joachim M. Schmidt Leuenberger, Andreas Limacher, Maria M. Wertli i Martin L. Verra. "Effect of goal-directed mobilisation intervention compared with standard care on physical activity among medical inpatients: protocol for the GoMob-in randomised controlled trial". BMJ Open 12, nr 5 (maj 2022): e058509. http://dx.doi.org/10.1136/bmjopen-2021-058509.

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IntroductionDespite the fact that immobilisation is a major contributor to morbidity and mortality, patients hospitalised in general internal medicine (GIM) wards spend up to 50% of time in bed. Previous studies in selected patient populations showed increased mobility after implementation of goal-directed mobilisation (GDM). Due to the study design used so far, the degree of evidence is generally low. The effect of GDM on clinical outcomes and economically relevant indicators in patients hospitalised in GIM wards is currently unknown. This study aims to evaluate a GDM intervention compared to standard care on physical activity (de Morton Mobility Index, DEMMI) in medical inpatients.Methods and analysisGoMob-in is a randomised, controlled, open-label study with blinded outcome assessment. We plan to enrol 160 inpatients with indication for physiotherapy on GIM wards of a tertiary hospital in Bern, Switzerland. Adult patients newly hospitalised on GIM wards will be included in the study. The primary outcome will be the change in the DEMMI score between baseline and 5 days. Secondary outcomes are change of DEMMI (inclusion to hospital discharge), mobilisation time (inclusion to day 5, inclusion to discharge), in-hospital delirium episodes, number of in-hospital falls, length of stay, number of falls within 3 months, number of re-hospitalisations and all-cause mortality within 3 months, change in independence during activities of daily living, concerns of falling, and quality of life within 3 months and destination after 3 months. Patients in the intervention group will be attributed a regularly updated individual mobility goal level made visible for all stakeholders and get a short educational intervention on GDM.Ethics and disseminationThis study has been approved by the responsible Ethics Board (Ethikkommission Bern/2020–02305). Written informed consent will be obtained from participants before study inclusion. Results will be published in open access policy peer-reviewed journals.Trial registration numberNCT04760392.

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Adam, Luise, Elisavet Moutzouri, Christine Baumgartner, Axel Lennart Loewe, Martin Feller, Khadija M’Rabet-Bensalah, Nathalie Schwab i in. "Rationale and design of OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people (OPERAM): a cluster randomised controlled trial". BMJ Open 9, nr 6 (czerwiec 2019): e026769. http://dx.doi.org/10.1136/bmjopen-2018-026769.

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Introduction Multimorbidity and polypharmacy are important risk factors for drug-related hospital admissions (DRAs). DRAs are often linked to prescribing problems (overprescribing and underprescribing), as well as non-adherence with drug regimens for different reasons. In this trial, we aim to assess whether a structured medication review compared with standard care can reduce DRAs in multimorbid older patients with polypharmacy. Methods and analysis OPtimising thERapy to prevent Avoidable hospital admissions in Multimorbid older people is a European multicentre, cluster randomised, controlled trial. Hospitalised patients ≥70 years with ≥3 chronic medical conditions and concurrent use of ≥5 chronic medications are included in the four participating study centres of Bern (Switzerland), Utrecht (The Netherlands), Brussels (Belgium) and Cork (Ireland). Patients treated by the same prescribing physician constitute a cluster, and clusters are randomised 1:1 to either standard care or Systematic Tool to Reduce Inappropriate Prescribing (STRIP) intervention with the help of a clinical decision support system, the STRIP Assistant. STRIP is a structured method performing customised medication reviews, based on Screening Tool of Older People’s Prescriptions/Screening Tool to Alert to Right Treatment criteria to detect potentially inappropriate prescribing. The primary endpoint is any DRA where the main reason or a contributory reason for the patient’s admission is caused by overtreatment or undertreatment, and/or inappropriate treatment. Secondary endpoints include number of any hospitalisations, all-cause mortality, number of falls, quality of life, degree of polypharmacy, activities of daily living, patient’s drug compliance, the number of significant drug–drug interactions, drug overuse and underuse and potentially inappropriate medication. Ethics and dissemination The local Ethics Committees in Switzerland, Ireland, The Netherlands and Belgium approved this trial protocol. We will publish the results of this trial in a peer-reviewed journal. Main funding European Union’s Horizon 2020 programme. Trial registration number NCT02986425, NCT000002183,NCT6012, U1111-1181-9400.

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Wertli, Maria M., Julian S. Flury, Sven Streit, Andreas Limacher, Vanessa Schuler, Asha-Naima Ferrante, Caroline Rimensberger i Manuel Haschke. "Efficacy of metamizole versus ibuprofen and a short educational intervention versus standard care in acute and subacute low back pain: a study protocol of a randomised, multicentre, factorial trial (EMISI trial)". BMJ Open 11, nr 10 (październik 2021): e048531. http://dx.doi.org/10.1136/bmjopen-2020-048531.

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IntroductionLow back pain (LBP) is among the top three most common diseases worldwide, resulting in a life with pain-related disability. To date, no study has assessed the efficacy of metamizole (dipyrone), a non-opioid analgesic and antipyretic prodrug compared with the conventional non-steroidal anti-inflammatory drug ibuprofen, in patients with an acute LBP episode. Further, it is unclear, whether a short educational intervention is superior to usual care alone.ObjectivesThe objective of this study is to assess first, whether metamizole is non-inferior to ibuprofen in a new episode of acute or subacute LBP. Second, we aim to assess whether a short educational intervention including evidence-based patient information on the nature of LBP is superior to usual care alone.Methods and analysisAn investigator-initiated multicentre, randomised, double blind trial using a factorial design will be performed. A total of 120 participants with a new episode of LBP will be recruited from GP practices, outpatient clinics and from emergency departments, and randomised into four different treatment groups: ibuprofen alone, ibuprofen and short intervention, metamizole alone, metamizole and short intervention. The primary endpoint for the medical treatment will be change in pain assessed on an 11-point Numeric Rating Scale after 14 days. The primary outcome for the short intervention will be change in the Core Outcome Measures Index assessed after 42 days.Ethics, dissemination and fundingThis study has been approved by the responsible Ethics Board (Ethikkommission Bern/2018-01986) and the Swiss Agency for Therapeutic Products (Swissmedic/2019DR4002). Results will be published in open access policy peer-reviewed journals. The study is funded by the Swiss National Science Foundation (grant number 32 003B-179346).Trial registration numberNCT04111315

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Rozprawy doktorskie na temat "Bern Trial"

Clark, L. J., R. Walser i E. W. Carpenter. "Green Bean Variety Trial, Safford Agricultural Center, 1998". College of Agriculture, University of Arizona (Tucson, AZ), 1999. http://hdl.handle.net/10150/219987.

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Twelve green bean varieties were grown in a replicated small plot trial on the Safford Agricultural Center in 1998. Varieties were picked regularly during the growing season. Yields are shown in tabular form and also graphically to indicate how each variety performed throughout the season. Rapids produced the highest yield with a total over 1.3 tons per acre. Two other varieties, Shade and HMX 6999, also performed well with yields over 1.0 tons per acre.

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Buhrow, Russ, i Lee Clark. "Results of 1985 Dry Bean Trials in Safford". College of Agriculture, University of Arizona (Tucson, AZ), 1986. http://hdl.handle.net/10150/200553.

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Clark, L. J., i E. W. Carpenter. "National Dry Bean Nursey Trials in Bonita, 1994". College of Agriculture, University of Arizona (Tucson, AZ), 1995. http://hdl.handle.net/10150/201469.

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Results of the 1994 National Cooperative Dry Bean Nursery Trials are reported in this report Thirty two varieties of eight different classes of beans were included in this replicated, small plot trial Bill-Z, the leading pinto bean variety in the area, was the highest yielding variety with a yield over 4200 pounds per acre. Chase, a pinto variety recently developed with strong rust tolerance, yielded over 4000 pounds per acre. Yields, seed per pound, days to bloom, seed fall duration and yield per day of seed fill are reported in this paper.

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Clark, Lee J., i E. W. Carpenter. "National Dry Bean Nursery Trials in Bonita, 1999". College of Agriculture, University of Arizona (Tucson, AZ), 2000. http://hdl.handle.net/10150/204103.

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This report contains the results of the 1999 National Cooperative Dry Bean Nursery Trials. This replicated, small plot trial contains thirty nine varieties of ten different classes of beans. Buster, a pinto variety was the highest yielding variety in the study with a yield over 3700 pounds per acre. Yields, percent moisture, aerial biomass, harvest index, seeds per pound, and plant populations are reported for this study.

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Clark, L. J., R. Walser i E. W. Carpenter. "National Dry Bean Nursery Trials in Bonita, 1998". College of Agriculture, University of Arizona (Tucson, AZ), 1999. http://hdl.handle.net/10150/205175.

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Results of the 1998 National Cooperative Dry Bean Nursery Trials are reported in this paper. Forty one varieties of nine different classes of beans were included in this replicated, small plot trial. AC Calmont, a dark red kidney variety was the highest yielding variety in the study with a yield over 2800 pounds per acre. Kodiak was the highest yielding pinto variety with a yield over 2700 pounds per acre. Yields, seed per pound, aerial biomass, harvest index, plant population days to 50% bloom and days to 50% pod set are reported for this study. In addition to the small plot replicated trial, a pinto variety strip trial was conducted at this site. Nine varieties, including the best varieties from past trials, were tested in this study. ISB 2001 was the leading variety in this study with a yield of 3276 pounds per acre.

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Clark, L. J., i E. W. Carpenter. "National Dry Bean Nursery Trials in Bonita, 1997". College of Agriculture, University of Arizona (Tucson, AZ), 1998. http://hdl.handle.net/10150/208285.

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Results of the 1997 National Cooperative Dry Bean Nursery Trials are reported in this paper. Thirty five varieties of seven different classes of beans were included in this replicated, small plot trial. Ole, a variety from Ag Canada was the highest yielding variety in the study with a yield over 4800 pounds per acre. Both Ole and ISB 2001 had yields higher than Bill Z, the highest yielding pinto bean in the area. Four varieties had yields over the 4000 pound per acre level. Yields, seed per pound, aerial biomass, harvest index, plant population and percent splits are also reported.

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Clark, L. J., V. Marcarian, E. W. Carpenter, R. E. Cluff i R. E. Call. "National Dry Bean Nursery Trials in Bonita, 1992-1993". College of Agriculture, University of Arizona (Tucson, AZ), 1994. http://hdl.handle.net/10150/201437.

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Results of the 1992 and 1993 National Cooperative Dry Bean Nursery Trials are reported in this report. More than 30 varieties of seven classes of beans were tested in small plot, replicated studies. Yields, seed size, harvest index, biomass production and plant populations are among the variables recorded in the trials.

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Clark, L. J., E. DeRosa, E. Schwenneson i R. E. Cluff. "Pinto Bean Variety Trials in Graham and Greenlee Counties, 1988". College of Agriculture, University of Arizona (Tucson, AZ), 1989. http://hdl.handle.net/10150/201076.

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Two pinto bean variety trials were grown in Greenlee and southern Graham counties. UI 114, the most commonly grown variety in both areas, was out yielded in both locations by other varieties. In Greenlee county, Luna, a New Mexico variety, surpassed UI 114 by approximately 100 pounds per acre. In Graham county, Olathe, a Colorado variety, out yielded UI 114 by more than 250 pounds per acre. At $40 per hundredweight, the latter difference translates into more than $100 per acre.

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Vermöhlen, Vanessa, Petra Schiller, Sabine Schickendantz, Marion Drache, Sabine Hussack, Andreas Gerber-Grote i Dieter Pöhlau. "Hippotherapy for patients with multiple sclerosis: A multicenter randomized controlled trial (MS-HIPPO)". Sage, 2018. https://tud.qucosa.de/id/qucosa%3A35527.

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Background: Evidence-based complementary treatment options for multiple sclerosis (MS) are limited. Objective: To investigate the effect of hippotherapy plus standard care versus standard care alone in MS patients. Methods: A total of 70 adults with MS were recruited in five German centers and randomly allocated to the intervention group (12 weeks of hippotherapy) or the control group. Primary outcome was the change in the Berg Balance Scale (BBS) after 12 weeks, and further outcome measures included fatigue, pain, quality of life, and spasticity. Results: Covariance analysis of the primary endpoint resulted in a mean difference in BBS change of 2.33 (95% confidence interval (CI): 0.03–4.63, p = 0.047) between intervention (n = 32) and control (n = 38) groups. Benefit on BBS was largest for the subgroup with an Expanded Disability Status Scale (EDSS) ⩾ 5 (5.1, p = 0.001). Fatigue (−6.8, p = 0.02) and spasticity (−0.9, p = 0.03) improved in the intervention group. The mean difference in change between groups was 12.0 (p < 0.001) in physical health score and 14.4 (p < 0.001) in mental health score of Multiple Sclerosis Quality of Life-54 (MSQoL-54). Conclusion: Hippotherapy plus standard care, while below the threshold of a minimal clinically important difference, significantly improved balance and also fatigue, spasticity, and quality of life in MS patients.

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Murphy, Mary. "Investigating the decision making process in patients with non-curative cancer who have been invited to join a clinical research trial". Thesis, Ulster University, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648023.

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Background: Clinical research that has no curative intent involving patients nearing the end of life, presents an ethically challenging situation. Previous research has demonstrated that these patients' understanding of clinical trials can be limited. Aim: This study seeks to understand the decision making process of patients with incurable cancer within the context of clinical research trials and to explore the clinical research teams' perspective on patients' decision making. Method: A modified grounded theory approach was used. This approach combined classic grounded theory methodology with the symbolic interaction element of Charmaz' grounded theory. Sixteen patients and eighteen research team members were interviewed. Data were analysed using a constant comparative method. Results: Nothing to lose emerged as the core category. Consenting patients made their decision instantly and were influenced by factors including, desire for increased longevity, an expectation to receive better attention, and the persuasive language used by doctors and nurses. They gave little consideration to the side-effects of the trial drug. Patients who declined did so after much deliberation . They were concerned about extra hospital visits and unknown side-effects. Oncologists and clinical research nurses believed that clinical care was highly protocolised and therefore better than care during standard treatment and as a result they thought that patients had nothing to lose by participating in a clinical trial. Conclusion: These findings demonstrate that patients' motivation for trial consent is complex. They perceive themselves in a paternalistic relationship with their doctor and thus are influenced by the emotional context and language used. Patients evaluated the risk of trial participation in the context of a limited lifespan thinking "I have nothing to lose." Consenting patients put significant value on the trial as a vehicle of hope and personalised care from the research team, whereas decliners decided they had more to lose by trial participation and opted for standard treatment.

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Książki na temat "Bern Trial"

Bürki, Christoph. Verwaltungsjustizbezogene Legalität und Prozessökonomie: Eine Untersuchung zum Verhältnis gerichtsorganisations- und verfahrensbezogener Gesetzmässigkeit und Prozesswirtschaftlichkeit unter Berücksichtigung der Verhältnisse im Bund und im Kanton Bern. Bern: Stämpfli Verlag, 2011.

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Page, David E. Valerie and the jelly bean trail. St. Petersburg, Fla: Willowisp Press, 1995.

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Musson, Nellie Eileen. A Bermuda trail blazer: The legendary Marjorie Louise Bean. Bermuda: Published in cooperation with the Business and Professional Women's Association of Bermuda (BPWA), an affiliate of the International Federation of Business and Professional Women (IFBPW), 1986.

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Deen, Ron. On the trail of Sawney Bean and his cannibal family. Glasgow: R. Deen, 1995.

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Bernhardt, William. Dark justice. New York: Ballantine Books, 1999.

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Bernhardt, William. Dark justice. New York: Ballantine Pub., 1999.

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Bernhardt, William. Naked justice. New York: Ballantine Books, 1997.

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Bernhardt, William. Capitol murder. New York: Random House Large Print, 2006.

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Bernhardt, William. Capitol Murder. New York: Random House Publishing Group, 2006.

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Bernhardt, William. Capitol murder: A novel. New York: Ballantine Books, 2006.

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Części książek na temat "Bern Trial"

McComas, Maggie. "Focus on Nestlé: the Bern Trial". W Infant Feeding, 43–56. London: Springer London, 1988. http://dx.doi.org/10.1007/978-1-4471-1618-9_4.

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Richardson, Brendan. "What Is Tribal Marketing, and Why Hasn't It Been More Widely Implemented?" W Tribal Marketing, Tribal Branding, 14–27. London: Palgrave Macmillan UK, 2013. http://dx.doi.org/10.1057/9781137349101_2.

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Niu, Xiaoshuang, i Yungan Tao. "New Developments in the Management of Nasopharyngeal Carcinoma". W Critical Issues in Head and Neck Oncology, 327–35. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_22.

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AbstractNasopharyngeal carcinomas (NPC) have unique characteristics with a specific geographic distribution and radiotherapy (RT) is the cornerstone of initial treatment due to its radiosensitive behaviour and deep-seated location. Intensity modulated radiotherapy (IMRT) has become the standard RT technique compared with 2D/3D and could reduce the late toxicities such as xerostomia. We established the international guideline for the delineation of clinical target volumes (CTV) and dose prioritization and constraint guideline for a better implementation of IMRT for NPC. The role of RT in addition to systemic therapy for the initially diagnosed metastatic NPC has recently been investigated in a randomized trial. The meta-analysis MAC-NPC confirmed the role of chemotherapy in addition to RT for NPC and established concomitant chemoradiotherapy (CCRT) as a standard of care in locally advanced (LA) NPC. In the recent actualization of MAC-NPC and network meta-analysis, more chemotherapy (adjuvant or induction) has been suggested to further improve treatment efficacy. However, a randomized trial did not shown survival benefit of adjuvant chemotherapy in addition to CCRT in LA-NPC. More recently, several phase III trials (French GORTEC trial and Chinese trials) showed benefit of induction chemotherapy (PF/TPF/GP) when added to cisplatin-based chemoradiotherapy. Preliminary study has failed to show benefit of adjuvant chemotherapy for the patients with detectable plasma Epstein Barr virus (EBV) DNA after chemoradiotherapy. The presentation will also focus on the ongoing trials with association of immune checkpoint inhibitors with chemoradiotherapy and the role of EBV DNA during or after treatment among others.

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Maifreda, Germano. "“My Profession Has Been and Is Letters and All Science.” Profile of a Defendant". W The Trial of Giordano Bruno, 15–39. New York: Routledge, 2022. http://dx.doi.org/10.4324/9781003026082-3.

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Allhoff, Peter, Ulrich Laaser i Joachim Heinrich. "Controlled Trial of Soya-Bean Oil in Myocardial Infarction". W Kompendium der Lipid-Studien, 36–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-95642-3_15.

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Rischin, Danny. "Update of Immune Therapies in Recurrent/Metastatic Head and Neck Cancer". W Critical Issues in Head and Neck Oncology, 297–306. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-63234-2_19.

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AbstractSince the initial reports of activity of pembrolizumab in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), investigation of the role of immune therapies has been the major focus of clinical trials in R/M HNSCC. Randomised trials initially with nivolumab and later with pembrolizumab established overall survival benefit in patients with R/M HNSCC previously treated with platinum compared to physicians choice of 2nd line therapy, and have led to regulatory approval around the world. More recently the Keynote-048 trial has compared both pembrolizumab monotherapy and pembrolizumab + platinum/5FU to the Extreme regimen of platinum/5FU/cetuximab in the first-line R/M setting. The key findings from this trial are that pembrolizumab monotherapy compared to Extreme improved overall survival in patients with PD-L1 combined positive score (CPS) ≥ 20 and ≥ 1, and that pembro/chemotherapy improved OS in CPS ≥ 20, CPS ≥ 1 and the total population. Relative to Extreme there was less toxicity in the monotherapy arm and comparable toxicity in the pembro/chemo arm. Based on this trial use of pembrolizumab as part of first-line treatment for R/M HNSCC is appropriate for the majority of patients, and represents a new standard of care. The focus has now moved to identifying combinations that may be superior to pembrolizumab monotherapy or to chemotherapy + pembrolizumab. Some of the more promising approaches under investigation in HNSCC are discussed in this chapter. In summary, immune therapies are now the cornerstone of management of R/M HNSCC with the approval of pembrolizumab in the first-line R/M setting.

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Patel, S. S., i Aditya Patel. "Clinical Research". W Elements of Clinical Study Design, Biostatistics & Research, 71–88. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123791123010008.

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The clinical trial could either be an Explanatory Trial/ Randomised Control Trial (RCT) or Correlational Trial/ Pragmatic Trial. For developing new molecules as a drug, RCTs require human studies conducted in 4 phases called Phase I to phase IV of clinical trials. Pragmatic Trials are Correlational Trials. As such RCT & Pragmatic Trials are not dichotomous, there is a continuum. A PRECIS has been developed to assess the said trials. The reverse pharmacology approach is recommended to generate scientific evidence to make herbal drugs more efficacious & safe. These aspects are elaborated on in this chapter.

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Patricoski, Jessica, Kory Kreimeyer, Archana Balan, Kent Hardart, Jessica Tao, Valsamo Anagnostou i Taxiarchis Botsis. "An Evaluation of Pretrained BERT Models for Comparing Semantic Similarity Across Unstructured Clinical Trial Texts". W Studies in Health Technology and Informatics. IOS Press, 2022. http://dx.doi.org/10.3233/shti210848.

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Processing unstructured clinical texts is often necessary to support certain tasks in biomedicine, such as matching patients to clinical trials. Among other methods, domain-specific language models have been built to utilize free-text information. This study evaluated the performance of Bidirectional Encoder Representations from Transformers (BERT) models in assessing the similarity between clinical trial texts. We compared an unstructured aggregated summary of clinical trials reviewed at the Johns Hopkins Molecular Tumor Board with the ClinicalTrials.gov records, focusing on the titles and eligibility criteria. Seven pretrained BERT-Based models were used in our analysis. Of the six biomedical-domain-specific models, only SciBERT outperformed the original BERT model by accurately assigning higher similarity scores to matched than mismatched trials. This finding is promising and shows that BERT and, likely, other language models may support patient-trial matching.

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Gosavi, Suraj S., Shivam V. Kale i Laxmikant N. Barde. "CLINICAL TRIALS: A CRITICAL COMPONENT OF DRUG DEVELOPMENT AND MEDICAL RESEARCH". W Futuristic Trends in Pharmacy & Nursing Volume 3 Book 14, 124–35. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bkpn14p2ch2.

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Clinical trials are an essential part of the drug development process, providing important data on the safety and efficacy of new drugs. In recent years, there has been a growing interest in clinical trials research, with a focus on improving the design and conduct of trials, as well as increasing access to trial data. One area of clinical trials research that has received significant attention in the use of the real-world data (RWD) and real – world evidence (RWE) in clinical trials. RWD refers to data collected outside of traditional clinical trial settings, such as electronic health records, claims data, and patient–generated data. RWE refers to the insights gained from the analysis of RWD, which can be used to inform clinical trial design and improve patient outcomes. Another area of clinical trials research is the development of innovative trial designs, such as adaptive trials, which allow for changes in the study design based on interim results. Adaptive trials can help to reduce the time and cost of drug development, while also improving the accuracy of trial results. There is also a growing focus on patient-centred clinical trials, which aim to incorporate patient perspectives and preferences into trial design and conduct. Patient-centred trials can help to improve recruitment and retention, as well as increase patient engagement and satisfaction. Finally, there is a need for greater transparency and accessibility in clinical trials research. This includes making trial data more readily available to researchers and the public, as well as improving the reporting of trial results.

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Lipton, Stuart A., i Harris A. Gelbard. "Development of adjunctive therapies for the neurological manifestations of AIDS: dementia and painful neuropathy". W The Neurology of AIDS, 735–40. Oxford University PressOxford, 2005. http://dx.doi.org/10.1093/oso/9780198526100.003.0064.

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Abstract Although cognitive impairment has been recognized as a major complication of HIV infection, it has been difficult to perform clinical trials for HIV-associated dementia. There is only one published double-blind, placebo-controlled multicenter trial for HIV-associated dementia. This trial was started more than 10 years ago and reports the benefit of high-dose zidovudine (formerly called AZT) in patients with established HIV-associated dementia. This trial of approximately 30 patients was significantly smaller than planned and it took a longer time than expected to reach this level of enrollment. Subsequent clinical trials planned by the AIDS Clinical Trial Group and other multicenter organizations have found recruitment of patients to therapeutic trials slow and difficult. Part of the difficulty has been in achieving a consensus about the definition of HIV-associated dementia and the difficulty in finding demented patients who can tolerate the fairly rigorous neuropsychological assessments that have become standard elements of these trials.

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Streszczenia konferencji na temat "Bern Trial"

Liu, Xiong, Greg L. Hersch, Iya Khalil i Murthy Devarakonda. "Clinical Trial Information Extraction with BERT". W 2021 IEEE 9th International Conference on Healthcare Informatics (ICHI). IEEE, 2021. http://dx.doi.org/10.1109/ichi52183.2021.00092.

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Hagesteijn, Gerco, Patrick Hooijmans i Karola van der Meij. "Correlation Allowances in Model Tests Results: A Delicate Balance Between Performance, Accuracy and Commercial Interests?" W ASME 2016 35th International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/omae2016-54842.

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Model tests at ballast and design draught are used to convert the sea trial results from the ballast trial draught to the contractual design draught. Correlation allowances in model test results and their effect on the trial performance prediction are of major importance. Nowadays it is not only typical to verify the contract speed but also the EEDI certification requires a verification of the speed power performance of the vessel. The use of a to favorable CA-value may lead to attractive performance figures, but also leads to higher fuel consumption figures than expected. Furthermore the design point of the propeller is affected, which leads to a too low light running margin and in some cases to erosive cavitation. During a study, large spreading in the values of the correlation allowances for design draughts have been found for merchant vessels tested at different model test institutes, but at ballast trial draught the spreading is much less. Can it happen that some institutes select favorable correlations allowances on the basis of inaccurate trial data of shipyards? Or should we accept a large spreading in correlation allowances and have these indeed been confirmed by sea trials at design draught? This paper will present a discussion using the experience of a large full scale trial database as well as the accuracy of model and full scale tests.

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El-Shafei, A., A. S. El-Kabbany i A. A. Younan. "Rotor Balancing Without Trial Weights". W ASME Turbo Expo 2002: Power for Land, Sea, and Air. ASMEDC, 2002. http://dx.doi.org/10.1115/gt2002-30633.

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The traditional balancing methods using trial or calibration weights are quite effective, yet too many trials may result in a lengthy balancing process. It had been suggested in the literature that it is possible to balance flexible rotors without the use of trial weights, if a rotor model is available. A procedure is developed in this paper to balance flexible rotors using complex modes and complex vibration measurements. It is shown that a complex rotor model is essential for the success of the technique. Moreover, careful calibration of the rotor model is the major cornerstone of the procedure. Experimental results illustrate the success of the procedure.

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Nakajo, Hidehiko, Taro Aoki, Takashi Murashima, Satoshi Tsukioka, Tadahiro Hyakudome, Tadahiko Ida i Tatsumasa Kabeno. "Long Cruising Trial of AUV “URASHIMA”". W ASME 2002 21st International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2002. http://dx.doi.org/10.1115/omae2002-28367.

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A Deep Sea Cruising AUV “URASHIMA” has been developed by JAMSTEC since 1998. The dimensions and weight are 10m (L), 1.3m (W), 1.5m (H), and about 7.5 tons in air. A main power source device system of AUV “URASHIMA” is a large capacity of lithium-ion (Li-ion) rechargeable battery system or Solid Polymer Electrolyte Fuel Cell (PEFC) system. AUV “URASHIMA” will be able to cruise for about 100km with Li-ion battery system and it will cruise for about 300km with fuel cell system. The cruising trial used by the fuel cell system will start at the end of 2002. The instruments for science researches are an automatic multi-water-sampling system, a CTDO, a side-scan sonar, a digital still camera with a thermoelectrically cooled CCD image sensor, a TV camera, and so on. Three operation modes, which are UROV mode, acoustic remote control mode and autonomous mode, are available. Those three kinds of modes are used acceding to each development stage and ocean researches. UROV mode is to monitor the state of the vehicle with fiber optics. At the first development stage of AUV “URASHIMA”, we carried out long cruising trial for about 100km and maximum operational depth trial at 3,500m used by Li-ion rechargeable battery system. URASHIMA was succeeded to reach at 3,518m depth of the seafloor at the sea trial of August 2001. We also carried out long cruising trial that was controlled by autonomous mode. Then, URASHIMA was cruised 70km distance at the sea trial of December 2001. We will have a next sea trail on May 2002 for 100km long cruising test. At the next development stage, we will carried out long cruising trial for 300km used by the fuel cell system.

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Birch, Jack, Rebecca Jones, Julia Mueller, Matthew McDonald, Rebecca Richards, Michael Kelly, Simon Griffin i Amy Ahern. "A systematic review of inequalities in the uptake of, adherence to and effectiveness of behavioural weight management interventions". W Building Bridges in Medical Science 2021. Cambridge Medicine Journal, 2021. http://dx.doi.org/10.7244/cmj.2021.03.001.1.

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Background: It has been suggested that interventions focusing on individual behaviour change, such as behavioural weight management interventions, may exacerbate health inequalities. These intervention-generated inequalities may occur at different stages, including intervention uptake, adherence and effectiveness. We conducted a systematic review to synthesise evidence on how different measures of inequality moderate the uptake of, adherence to and effectiveness of behavioural weight management interventions in adults. Methods: We updated a previous systematic literature review from the US Preventive Services Taskforce to identify trials of behavioural weight management interventions in adults that could be conducted in or recruited from primary care. Medline, Cochrane database (CENTRAL) and PsycINFO were searched. Only randomised controlled trials and cluster-randomised controlled trials were included. Two investigators independently screened articles for eligibility and conducted risk of bias assessment. We curated publication families for eligible trials. The PROGRESS-Plus acronym (place of residence, race/ethnicity, occupation, gender, religion, education, socioeconomic status, social capital, plus other discriminating factors) was used to consider a comprehensive range of health inequalities. Data on trial uptake, intervention adherence, weight change, and PROGRESS-Plus related-data were extracted. Results: Data extraction in currently underway. A total of 108 studies are included in the review. Data will be synthesised narratively and through the use of Harvest Plots. A Harvest plot for each PROGRESS-Plus criterion will be presented, showing whether each trial found a negative, positive or no health inequality gradient. We will also identify potential sources of unpublished original research data on these factors which can be synthesised through a future individual participant data meta- analysis. Conclusions and implications: The review findings will contribute towards the consideration of intervention-generated inequalities by researchers, policy makers and healthcare and public health practitioners. Authors of trials included in the completed systematic review may be invited to collaborate on a future IPD meta-analysis. PROSPERO registration number: CRD42020173242

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Krebs, Hermano I., Neville Hogan, Bruce Volpe, Mindy Aisen, Lisa Edelstein i Christa Diels. "Robot-Aided Neuro-Rehabilitation in Stroke: Neuro-Recovery for Thalamic Lesion". W ASME 1999 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/imece1999-0081.

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Abstract We are applying robotics and information technology to assist, enhance, and quantify neuro-rehabilitation. Our goal is a new class of interactive, user-affectionate clinical devices designed not only for evaluating patients, but also for delivering meaningful therapy via engaging “video games.” Notably, the novel robot MIT-MANUS has been designed and programmed for clinical neurological applications, and has undergone extensive clinical trials for more than four years at Burke Rehabilitation Hospital – White Plains, NY. This paper will review the main result of the pilot clinical trial of the 20 patients focusing on the consequences of thalamic lesions.

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van den Boom, Henk J. J., i Thijs W. F. Hasselaar. "Ship Speed-Power Performance Assessment". W SNAME Maritime Convention. SNAME, 2014. http://dx.doi.org/10.5957/smc-2014-t04.

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The speed/power characteristics of ships have always been at the core of ship design. To prove contractually agreed values, speed trials are conducted by the yard prior to delivery of the ship to the owner. In the past schedule integrity of the vessel was often the most important factor for the speed requirement. Today, owners and operators are keen to reduce fuel consumption to decrease operational costs. So far a variety of methods for conducting and analyzing speed/power trials have been used by shipyards. With the assistance of the Sea Trial Analysis-Joint Industry Project, ITTC developed guidelines for the execution and analysis of speed/power trials compliant with IMO EEDI. The need to reduce fuel costs and exhaust gas emissions including the upcoming environmental regulations such as EEOI by IMO urge for reliable monitoring of ship performance in service conditions. This requires accurate information of the speed through water. Although the speed log is one of the oldest instruments on board it is not considered the most reliable one. Results of an extensive monitoring campaign on board a 1800 TEU container vessel equipped with six speed logs within SPA-JIP will be presented. The state of art of performance monitoring will be presented.

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Wilkman, Göran, Mika Hovilainen, Teemu Heinonen, Esa Hakanen i Niko Miettinen. "Development of the New Icebreaking Tug for Northern Caspian Sea". W SNAME 10th International Conference and Exhibition on Performance of Ships and Structures in Ice. SNAME, 2012. http://dx.doi.org/10.5957/icetech-2012-150.

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The development of oil exploration/production offshore Kazakhstan in the northern Caspian Sea has been proceeding quite extensively. New vessels are needed and one example of recent vessel deliveries are five icebreaking tugs, Mangystau 1-5. The first vessel has been in operation 1.5 years and full-scale ice trials were performed in March 2012. The project has been really international as the basic design was done by Aker Arctic in Finland, the shipbuilding contract was done between STX OSV (Norway) and Caspian Offshore Construction (COC) (Kazakhstan). The vessels were built in Romania by STX. The paper will first of all describe how this arrangement worked out, how the vessels look like and finally discuss the full-scale trial results.

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Birk, A. M., i D. Vandam. "Infra-Red Signature Suppression for Marine Gas Turbines: Comparison of Sea Trial and Model Test Results for the DRES Ball IRSS System". W ASME 1992 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1992. http://dx.doi.org/10.1115/92-gt-310.

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Sea Trials have recently been underway for Canada’s new City Class Patrol Frigate (CPF). These trials provided the first opportunity to measure the performance of the new DRES Ball Infra-red Signature Suppression (IRSS) system installed on a ship. Prior to these trials 1/4 scale hot flow model test and computer simulation performance results were available. The CPF DRES Ball IRSS systems are installed on the exhaust uptakes of the GE LM2500 main gas turbines. The DRES Ball provides both metal surface cooling for all view angles and plume cooling. The DRES Ball significantly reduces the IR signature of the LM2500 exhaust. This paper presents a comparison between the 1/4 scale hot flow model test results with the full scale sea trial results. Performance variables included in the comparison are; metal surface temperatures, back pressure, plume temperature distribution, and surface static pressures. Because of the confidential nature of the DRES Ball system performance, all classified data has been nondimensionalized so that only relative comparisons can be made between the full scale and 1/4 scale data. The results show that the full scale system performs better than the 1/4 scale model because of Reynolds number effects. The plume temperature, surface temperatures and back pressure were all lower (better) than in the 1/4 scale model tests. One of the original concerns with the installation was that relative wind would degrade the performance of the DRES Ball onboard a ship. The wind effect was found to be benign during the trials.

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Carvalho, Diogo, Luis Silva, Miguel Carvalho, Mariana Dias, Nélson Costa, Duarte Folgado, Maria Lua Nunes, Hugo Gamboa, Kristine Andza i Elazer Edelman. "Cardiovascular Reactivity (CVR) During Repetitive Work in the Presence of Fatigue". W Intelligent Human Systems Integration (IHSI 2023) Integrating People and Intelligent Systems. AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1002833.

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Fatigue during repetitive tasks in the workplace has been intrinsically connected with occupational risk and a reduction in productivity. Currently, the measures taken are based on subjective interpretations of fatigue by the workers or on direct muscular activity, which then make up for a cumulative evaluation of fatigue. The concept of “Industry 4.0” wearable devices would allow a continuous monitoring and thus, a more realistic representation of their fatigue levels.Aim: To quantify heart rate variability, measuring cardiovascular responsiveness, during repetitive work when fatigue is present. Tasks: A protocol was developed to simulate a real-life workplace scenario with a set of low-intensity repetitive tasks that are commonly practiced. The signals obtained were then processed, and heart rate variability was calculated using fractal analysis and time domain variables. Hypothesis: It was hypothesized that 1) the amount of variability and 2) the structure of variability will change during repetitive work in the presence of fatigue.Methodology: Participants were asked to perform three 10-minute trials of a repetitive task. Between each trial, a muscular fatigue protocol was carried out, targeting the main agonist muscle. An ECG was collected during the trials (Baseline, Fatigue 1, and Fatigue 2) through a wearable band placed on the level of the xiphoid appendix. Results: The nonlinearity of the heart rate variability showed no statistically significant changes, unlike the time domain measures that significantly differentiated the baseline trial from the fatigue trials, namely the Standard Deviation of NN intervals, the Root Mean Square of successive RR interval differences, Coefficient of Variation, and Heart Rate itself. Conclusions: These results are enthusiastic for applying algorithms that use heart rate variability to quantify cardiovascular responsiveness to fatigue during repetitive work. They show that with information in the time domain, it is possible to verify physiological changes that the worker is undergoing. Additionally, these changes are also related to the amount of variability and not to the fractal structure of heart rate variability.

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Raporty organizacyjne na temat "Bern Trial"

Soto-arias, Jose Pablo, i Gary P. Munkvold. Bean Leaf Beetle-Phomopsis Management Trials on Soybean. Ames: Iowa State University, Digital Repository, 2010. http://dx.doi.org/10.31274/farmprogressreports-180814-420.

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Delate, Kathleen, Heather Friedrich i Robert Burcham. Evaluation of Organic Pest Management Treatments for Bean Leaf Beetle--Neely-Kinyon Trial, 2002. Ames: Iowa State University, Digital Repository, 2003. http://dx.doi.org/10.31274/farmprogressreports-180814-1226.

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Delate, Kathleen, Heather Friedrich, Andrea McKern i Robert Burcham. Evaluation of Organic Pest Management Treatments for Bean Leaf Beetle--Neely-Kinyon Trial, 2003. Ames: Iowa State University, Digital Repository, 2004. http://dx.doi.org/10.31274/farmprogressreports-180814-1298.

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Köck, Patrick, Arndt-Lukas Klaassen, M. Meyer, J. Kindler i M. Kaess. Cannabinoids as therapeutics in child and adolescent psychiatry. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, marzec 2023. http://dx.doi.org/10.37766/inplasy2023.3.0017.

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Review question / Objective: P = Children and adolescents with psychiatric disorders; I = Cannabinoids as therapeutic product / medication; C = if randomised controlled trial, placebo; O = Evaluation of psychiatric symptoms (BDI for depression, symptom severity scales in case of ADHD or Autism Spectrum Disorders); S = Randomized controlled trials, controlled trials, case studies. Rationale: Cannabinoids especially THC and CBD have gained increasing scientific interest. Various studies have been published assessing the therapeutic applications of cannabinoids in psychiatry. Several systematic reviews have been published for application of cannabinoids in psychiatry for adults, however there is no recent systematic review assessing applications for child and adolescent psychiatry.

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Delate, Kathleen, Andrea McKern i Robert Burcham. Evaluation of Organic Pest Management Treatments for Bean Leaf Beetle and Soybean Aphid--Neely-Kinyon Trial, 2004. Ames: Iowa State University, Digital Repository, 2005. http://dx.doi.org/10.31274/farmprogressreports-180814-2692.

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Luo, Minjing, Yilin Li, Yingqiao Wang, Jinghan Huang, Zhihan Liu, Yicheng Gao, Qianyun Chai, Yuting Feng, Jianping Liu i Yutong Fei. The Fragility of Statistically Significant Findings from Depression Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, kwiecień 2023. http://dx.doi.org/10.37766/inplasy2023.4.0086.

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Review question / Objective: The Fragility of Statistically Significant Findings from Depression Randomized Controlled Trials. Condition being studied: Depression is a mental disorder characterized by a range of symptoms, including loss of memory and sleep, decreased energy, feelings of guilt or low mood, disturbed appetite, poor concentration, and an increased risk of suicide. According to a systematic analysis of the Global Burden of Disease Study 2019, depression is recognized as the leading cause of disease burden for mental disorders, accounting for the largest proportion of disability-adjusted life years (DALYs) at 37.3%. The fragility index (FI), which is the minimum number of changes from events to non-events resulting in loss of statistical significance, has been suggested as a means to aid the interpretation of trial results, as the potential inadequacy about robustness of threshold P-value as a tool for reporting binary outcomes in clinical trials. In this systematic review, we want to calculate the FI of randomized controlled trials (RCTs) in depression.

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Mudge, Christopher R., i Kurt D. Getsinger. Comparison of Generic and Proprietary Aquatic Herbicides for Control of Invasive Vegetation : Part 2. Emergent Plants. Engineer Research and Development Center (U.S.), listopad 2021. http://dx.doi.org/10.21079/11681/39679.

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Aquatic herbicides are one of the most effective and widespread ways to manage nuisance vegetation in the US After the active ingredient is selected, often there are numerous proprietary and generic branded products to select from. To date, limited efforts have been made to compare the efficacy of brand name and generic herbicides head to head; therefore, at tot al of 20 mesocosm trials were conducted to evaluate various 2,4 -D, glyphosate, imazapyr, and triclopyr products against alligatorweed (Alternanthera philoxeroides (Mart.) Griseb.), southern cattail (hereafter referred to as cattail, Typha domingensis Pers.), and creeping water primrose (hereafter referred as primrose, Ludwigia peploides (Kunth) P.H. Raven). All active ingredients were applied to foliage at broadcast rates commonly used in applications to public waters. Proprietary and generic 2,4 -D, glyphosate, imazapyr, and triclopyr were efficacious and provided 39 to 99% control of alligatorweed, cattail and primrose in 19 of the 20 trials. There were no significant differences i n product performance except glyphosate vs. alligatorweed (trial 1, Rodeo vs. Roundup Custom) and glyphosate vs. cattail (trial 1, Rodeo vs. Glyphosate 5.4). These results demonstrate under small -scale conditions, the majority of the generic and proprietary herbicides provided similar control of emergent vegetation, regardless of active ingredient

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Mudge, Christopher, i Kurt Getsinger. Comparison of generic and proprietary aquatic herbicides for control of invasive vegetation; part 3 : submersed plants. Engineer Research and Development Center (U.S.), wrzesień 2021. http://dx.doi.org/10.21079/11681/42061.

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Herbicide selection is key to efficiently managing nuisance vegetation in our nation’s waterways. After selecting the active ingredient, there still remains multiple proprietary and generic products to choose from. Recent small-scale research has been conducted to compare the efficacy of these herbicides against floating and emergent species. Therefore, a series of mesocosm and growth chamber trials were conducted to evaluate subsurface applications of the following herbicides against submersed plants: diquat versus coontail (Ceratophyllum demersum L.), hydrilla (Hydrilla verticillata L.f. Royle), southern naiad (Najas guadalupensis (Sprengel) Magnus), and Eurasian watermilfoil (Myriophyllum spicatum L.); flumioxazin versus coontail, hydrilla, and Eurasian watermilfoil; and triclopyr against Eurasian watermilfoil. All active ingredients were applied at concentrations commonly used to manage these species in public waters. Visually, all herbicides within a particular active ingredient performed similarly with regard to the onset and severity of injury symptoms throughout the trials. All trials, except diquat versus Eurasian watermilfoil, resulted in no differences in efficacy among the 14 proprietary and generic herbicides tested, and all herbicides provided 43%–100% control, regardless of active ingredient and trial. Under mesocosm and growth chamber conditions, the majority of the generic and proprietary herbicides evaluated against submersed plants provided similar control.

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Cowell, Luke, i Ivan Carlos. PR-283-18202-R01 Improved SoLoNox T70S and T130S Controls to Reduce Part Load Emissions. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), luty 2021. http://dx.doi.org/10.55274/r0012019.

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An executed NDA is required from Solar Turbines to have access to this document. The low load control algorithm for Solar Turbines' Taurus 70-10802S and Titan 130-20502S has been modified and evaluated in two field trials at the Kinder Morgan Wharton 301 and Enbridge Sabal Trail Alexander City Compressor Stations. The new algorithm extends temperature control, via bleed valve modulation, to lower engine speed settings now covering operation from full load to idle vs full load to 50% load with the prior production control method. The pilot fuel control schedule has also been optimized along with the temperature control schedule. The new control algorithm is designated as Enhanced Emissions Control (EEC). A Mobile Emissions Lab was deployed for the Taurus 70S site and for the Titan 130S site. The field trials spanned 12 months for the Taurus 70S and 8 months for the Titan 130S. Data was collected over a wide range of temperatures.

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McPhedran, R., K. Patel, B. Toombs, P. Menon, M. Patel, J. Disson, K. Porter, A. John i A. Rayner. Food allergen communication in businesses feasibility trial. Food Standards Agency, marzec 2021. http://dx.doi.org/10.46756/sci.fsa.tpf160.

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Background: Clear allergen communication in food business operators (FBOs) has been shown to have a positive impact on customers’ perceptions of businesses (Barnett et al., 2013). However, the precise size and nature of this effect is not known: there is a paucity of quantitative evidence in this area, particularly in the form of randomised controlled trials (RCTs). The Food Standards Agency (FSA), in collaboration with Kantar’s Behavioural Practice, conducted a feasibility trial to investigate whether a randomised cluster trial – involving the proactive communication of allergen information at the point of sale in FBOs – is feasible in the United Kingdom (UK). Objectives: The trial sought to establish: ease of recruitments of businesses into trials; customer response rates for in-store outcome surveys; fidelity of intervention delivery by FBO staff; sensitivity of outcome survey measures to change; and appropriateness of the chosen analytical approach. Method: Following a recruitment phase – in which one of fourteen multinational FBOs was successfully recruited – the execution of the feasibility trial involved a quasi-randomised matched-pairs clustered experiment. Each of the FBO’s ten participating branches underwent pair-wise matching, with similarity of branches judged according to four criteria: Food Hygiene Rating Scheme (FHRS) score, average weekly footfall, number of staff and customer satisfaction rating. The allocation ratio for this trial was 1:1: one branch in each pair was assigned to the treatment group by a representative from the FBO, while the other continued to operate in accordance with their standard operating procedure. As a business-based feasibility trial, customers at participating branches throughout the fieldwork period were automatically enrolled in the trial. The trial was single-blind: customers at treatment branches were not aware that they were receiving an intervention. All customers who visited participating branches throughout the fieldwork period were asked to complete a short in-store survey on a tablet affixed in branches. This survey contained four outcome measures which operationalised customers’: perceptions of food safety in the FBO; trust in the FBO; self-reported confidence to ask for allergen information in future visits; and overall satisfaction with their visit. Results: Fieldwork was conducted from the 3 – 20 March 2020, with cessation occurring prematurely due to the closure of outlets following the proliferation of COVID-19. n=177 participants took part in the trial across the ten branches; however, response rates (which ranged between 0.1 - 0.8%) were likely also adversely affected by COVID-19. Intervention fidelity was an issue in this study: while compliance with delivery of the intervention was relatively high in treatment branches (78.9%), erroneous delivery in control branches was also common (46.2%). Survey data were analysed using random-intercept multilevel linear regression models (due to the nesting of customers within branches). Despite the trial’s modest sample size, there was some evidence to suggest that the intervention had a positive effect for those suffering from allergies/intolerances for the ‘trust’ (β = 1.288, p<0.01) and ‘satisfaction’ (β = 0.945, p<0.01) outcome variables. Due to singularity within the fitted linear models, hierarchical Bayes models were used to corroborate the size of these interactions. Conclusions: The results of this trial suggest that a fully powered clustered RCT would likely be feasible in the UK. In this case, the primary challenge in the execution of the trial was the recruitment of FBOs: despite high levels of initial interest from four chains, only one took part. However, it is likely that the proliferation of COVID-19 adversely impacted chain participation – two other FBOs withdrew during branch eligibility assessment and selection, citing COVID-19 as a barrier. COVID-19 also likely lowered the on-site survey response rate: a significant negative Pearson correlation was observed between daily survey completions and COVID-19 cases in the UK, highlighting a likely relationship between the two. Limitations: The trial was quasi-random: selection of branches, pair matching and allocation to treatment/control groups were not systematically conducted. These processes were undertaken by a representative from the FBO’s Safety and Quality Assurance team (with oversight from Kantar representatives on pair matching), as a result of the chain’s internal operational restrictions.

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