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Pirzado, Muhammad Suleman. "Investigating cell senescence in basal cell carcinoma". Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8633.
Pełny tekst źródłaVerhaegh, Marcus Emile Johannes Maria. "Growth characteristics of basal cell carcinoma". Maastricht : Maastricht : UPM, Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8543.
Pełny tekst źródłaRichmond-Sinclair, Naomi Monique. "The epidemiology of basal cell carcinoma". Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/68152/1/Naomi_Richmond-Sinclair_Thesis.pdf.
Pełny tekst źródłaGore, S. "Neuronal differentiation markers in basal cell carcinoma". Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445574/.
Pełny tekst źródłaGao, Wendi. "Investigation of immune privilege in basal cell carcinoma". University of British Columbia, 2017. http://hdl.handle.net/2429/63553.
Pełny tekst źródłaMedicine, Faculty of
Experimental Medicine, Division of
Medicine, Department of
Graduate
Koreeda, Satoshi. "Basal cell carcinoma cells resemble follicular matrix cells rather than follicular bulge cells". Kyoto University, 2004. http://hdl.handle.net/2433/147556.
Pełny tekst źródłade, Zwaan Sally Elizabeth. "The Genetics of Basal Cell Carcinoma of the Skin". Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/3878.
Pełny tekst źródłade, Zwaan Sally Elizabeth. "The Genetics of Basal Cell Carcinoma of the Skin". University of Sydney, 2008. http://hdl.handle.net/2123/3878.
Pełny tekst źródłaBCC is the commonest cancer in European-derived populations and Australia has the highest recorded incidence in the world, creating enormous individual and societal cost in management of this disease. The incidence of this cancer has been increasing internationally, with evidence of a 1 to 2% rise in incidence in Australia per year over the last two decades. The main four epidemiological risk factors for the development of BCC are ultraviolet radiation (UVR) exposure, increasing age, male sex, and inability to tan. The pattern and timing of UVR exposure is important to BCC risk, with childhood and intermittent UVR exposure both associated with an increased risk. The complex of inherited characteristics making up an individual’s ‘sun sensitivity’ is also important in determining BCC risk. Very little is known about population genetic susceptibility to BCC outside of the rare genodermatosis Gorlin syndrome. Mutations in the tumour suppressor gene patched (PTCH) are responsible for this BCC predisposition syndrome and the molecular pathway and target genes of this highly conserved pathway are well described. Derangments in this pathway occur in sporadic BCC development, and the PTCH gene is an obvious candidate to contribute to non-syndromic susceptibility to BCC. The melanocortin 1 receptor (MC1R) locus is known to be involved in pigmentary traits and the cutaneous response to UVR, and variants have been associated with skin cancer risk. Many other genes have been considered with respect to population BCC risk and include p53, HPV, GSTs, and HLAs. There is preliminary evidence for specific familial aggregation of BCC, but very little known about the causes. 56 individuals who developed BCC under the age of 40 in the year 2000 were recruited from the Skin and Cancer Foundation of Australia’s database. This represents the youngest 7 – 8% of Australians with BCC from a database that captures approximately 10% of Sydney’s BCCs. 212 of their first degree relatives were also recruited, including 89 parents and 123 siblings of these 56 probands. All subjects were interviewed with respect to their cancer history and all reports of cancer verified with histopathological reports where possible. The oldest unaffected sibling for each proband (where available) was designated as an intra-family control. All cases and control siblings filled out a questionnaire regarding their pigmentary and sun sensitivity factors and underwent a skin examination by a trained examiner. Peripheral blood was collected from these cases and controls for genotyping of PTCH. All the exons of PTCH for which mutations have been documented in Gorlin patients were amplified using PCR. PCR products were screened for mutations using dHPLC, and all detectable variants sequenced. Prevalence of BCC and SCC for the Australian population was estimated from incidence data using a novel statistical approach. Familial aggregation of BCC, SCC and MM occurred within the 56 families studied here. The majority of families with aggregation of skin cancer had a combination of SCC and BCC, however nearly one fifth of families in this study had aggregation of BCC to the exclusion of SCC or MM, suggesting that BCCspecific risk factors are also likely to be at work. Skin cancer risks for first-degree relatives of people with early onset BCC were calculated: sisters and mothers of people with early-onset BCC had a 2-fold increased risk of BCC; brothers had a 5-fold increased risk of BCC; and sisters and fathers of people with early-onset BCC had over four times the prevalence of SCC than that expected. For melanoma, the increased risk was significant for male relatives only, with a 10-fold increased risk for brothers of people with early-onset BCC and 3-fold for fathers. On skin examination of cases and controls, several phenotypic factors were significantly associated with BCC risk. These included increasing risk of BCC with having fair, easyburning skin (ie decreasing skin phototype), and with having signs of cumulative sun damage to the skin in the form of actinic keratoses. Signs reflecting the combination of pigmentary characteristics and sun exposure - in the form of arm freckling and solar lentigines - also gave subjects a significantly increased risk BCC. Constitutive red-green reflectance of the skin was associated with decreased risk of BCC, as measured by spectrophotometery. Other non-significant trends were seen that may become significant in larger studies including associations of BCC with propensity to burn, moderate tanning ability and an inability to tan. No convincing trend for risk of BCC was seen with the pigmentary variables of hair or eye colour, and a non-significant reduced risk of BCC was associated with increasing numbers of seborrhoeic keratoses. Twenty PTCH exons (exons 2, 3, 5 to 18, and 20 to 23) were screened, accounting for 97% of the coding regions with published mutations in PTCH. Nine of these 20 exons were found to harbour single nucleotide polymorphisms (SNPs), seen on dHPLC as variant melting curves and confirmed on direct sequencing. SNPs frequencies were not significantly different to published population frequencies, or to Australian general population frequencies where SNP database population data was unavailable. Assuming a Poisson distribution, and having observed no mutations in a sample of 56, we can be 97.5% confident that if there are any PTCH mutations contributing to early-onset BCC in the Australian population, then their prevalence is less than 5.1%. Overall, this study provides evidence that familial aggregation of BCC is occurring, that first-degree relatives are at increased risk of all three types of skin cancer, and that a combination of environmental and genetic risk factors are likely to be responsible. The PTCH gene is excluded as a major cause of this increased susceptibility to BCC in particular and skin cancer in general. The weaknesses of the study design are explored, the possible clinical relevance of the data is examined, and future directions for research into the genetics of basal cell carcinoma are discussed.
Wallberg, Peter. "A clinical and experimental study of basal cell carcinoma : aspects on epidemiology, genetics and microphysiology /". Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3993-4/.
Pełny tekst źródłaWong, Deanna A. "Cytokine profiles in regressing and non-regressing basal cell carcinomas". Thesis, The University of Sydney, 1998. https://hdl.handle.net/2123/27687.
Pełny tekst źródłaPantazi, Eleni. "The role of GLI2 in human basal cell carcinoma tumourigenesis". Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/508.
Pełny tekst źródłaHorlock, Nigel. "The cell biology of basal cell carcinoma : relationship to histology and clinical outcome". Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391606.
Pełny tekst źródłaUndén, Anne Birgitte. "Studies on basal cell carcinoma with emphasis on the role of the human homologue of the drosophila patched gene /". Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2788-X.
Pełny tekst źródłaThissen, Monique Rosalie Thérèse Mathieu. "Treatment of basal cell carcinoma in the light of photodynamic therapy". [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2000. http://arno.unimaas.nl/show.cgi?fid=5962.
Pełny tekst źródłaCheng, Hui Mei. "Diagnostic accuracy of optical coherence tomography in superficial basal cell carcinoma". Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14183.
Pełny tekst źródłaCalderón, Gómez Tomás Alberto. "Detecting basal cell carcinoma in skin histopathological images using deep learning". Thesis, Massachusetts Institute of Technology, 2018. https://hdl.handle.net/1721.1/121624.
Pełny tekst źródłaThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (page 51).
In this thesis we explore different machine learning techniques that are common in image classification to detect the presence of Basal Cell Carcinoma (BCC) in digital skin histological images. Since digital histology images are extremely large, we first focused on determining the presence of BCC at the patch level, using pre-trained deep convolutional neural networks as feature extractors to compensate for the size of our datasets. The experimental results show that our patch level classifiers obtained an area under the receiver operating characteristic curve (AUC) of 0.981. Finally, we used our patch classifiers to generate a bag of scores for a given whole slide image (WSI), and attempted multiple ways of combining these scores to produce a single significant score to predict the presence of BCC in the given WSI. Our best performing model obtained an AUC of 0.991 in 86 samples of digital skin biopsies, 43 of which had BCC.
by Tomás Alberto Calderón Gómez.
M. Eng.
M.Eng. Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science
Searby, Caroline. "Development of a topical formulation for the treatment of basal cell carcinoma". Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/55529/.
Pełny tekst źródłaEl-Genidy, Noha A. F. "Association of PTCH polymorphism with clinical phenotype in basal cell carcinoma patients". Thesis, Keele University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.436141.
Pełny tekst źródłaFarndon, Peter Anthony. "The gorlin (naevoid basal cell carcinoma) syndrome : a clinical and genetic study". Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307577.
Pełny tekst źródłaKaur, Ravneet. "THRESHOLDING METHODS FOR LESION SEGMENTATION OF BASAL CELL CARCINOMA IN DERMOSCOPY IMAGES". OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1367.
Pełny tekst źródłaKass, Youssef Khalil. "Identification of cellular origin and molecular mechanism in basal and squamous cell carcinomas". Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209771.
Pełny tekst źródłaBCCs result from aberrant activation of HH signaling and several mouse models carrying mutations in HH signaling genes are capable to form tumors resembling to human BCCs.
To identify the cell lineage at the origin of BCC and to investigate the role of stem cells in tumor initiation, we followed a genetic approach where we conditionally expressed SmoM2 oncogene (a constitutively active Smoothened mutant) in distinct skin epidermal compartments including SCs. Targeting basal epidermis cells, showed that only SmoM2-clones in the inter follicular epidermis (IFE) and the infundibulum can progress into BCC, whereas SmoM2 expression in Bulge SCs or in matrix transit amplifying progenitor cells never leads to BCC formation. Progressively after SmoM2 expression, tumor-initiating cells lose their normal differentiation to adopt a hair placode-like shape and markers, demonstrating that biochemical and morphological tumour features can be misleading in extrapolating their cellular origin.
The molecular changes occurring in tumor initiating cells and the mechanisms regulating the early steps of cancer development are poorly characterized for the majority of tumors. To address these questions in BCC, we took advantage of our ability to isolate SmoM2 expressing cells at different stages of tumor initiation and progression. Transcriptional profiling of SmoM2-basal IFE cells isolated one week (normal histology) and 4 weeks (dysplastic lesion), suggests that adult IFE cells undergo a reprogramming into embryonic hair follicle (EHFP) like fate. In addition, we showed that Wnt/β-catenin signaling is essential for BCC initiating cell reprogramming into EHFP like fate and for tumor initiation in a cell autonomous manner. Finally, we show that EHFP reprogramming occurs also in human BCCs in addition to the presence of a similar canonical Wnt activation signature to the one revealed in the SmoM2-BCC mouse model.
SCC is the second most frequent skin cancers after BCC and mutations in p53 and Ras genes has been suggested to be potentially the primary events in this tumour. SCCs present signs of squamous differentiation, suggesting that SCCs may originate from the inter follicular epidermis (IFE). To identify the cell lineage at the origin of SCC and the role of the hair follicle SCs in tumor initiation, we use a genetic tools driving oncogenic KRas (KRasG12D) expression at physiological levels in different epidermal compartments.
Targeting KRasG12D expression in bulge SCs and their progeny or in IFE results in benign tumor development with no sign of malignant transformation. In contrast, KRasG12D expression in HF Transit amplifying (TA) matrix cells do not promotes any macroscopic tumors or microscopic defects in the epidermis. Interestingly, papillomas arising from the IFE express follicular markers such as CD34 and K17, indicating that the expression of HF markers by tumor cells does not necessarily reflect their cellular origin. Using a combination of deletion of both p53 alleles together with KRasG12D expression, we showed that bulge SCs and/or their progeny but not HF matrix TA cells, promote SCC formation, suggesting that additional genetic hits such as p53 are required to promote full-blown invasive skin SCC.
In summary, our work demonstrated the non-follicular origin of BCC resulting from Smo mutation, as well as the implication of the IFE progenitors in tumor initiation. We also revealed the progressive reprogramming of BCC initiating cells towards an EHFP-like fate and the key role of Wnt/β-catenin pathway in this process. In contrast, we showed the competence of several epidermal lineages to initiate benign tumors upon expression of KRasG12D oncogene at physiological levels. We also demonstrated that lineage -specific markers expression within tumor cells does not necessarily reflect their cellular origin. Finally, we demonstrated the requirement of additional hits, such as P53 loss, to promote malignant progression in the context of oncogenic Ras.
Doctorat en Sciences biomédicales et pharmaceutiques
info:eu-repo/semantics/nonPublished
Krekels, Gertruud Anna Maria. "Basal cell carcinoma, a disease on the increase implications for treatment and prevention /". [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8428.
Pełny tekst źródłaHauser, Jennifer E. M. S. "Genetic Epidemiology of Radiation Sensitivity and Basal Cell Carcinoma in Childhood Cancer Survivors". University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1447689192.
Pełny tekst źródłaBrownlie, Laura. "Differential gene expression studies in non-melanoma skin cancer". Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323449.
Pełny tekst źródłaAsplund, Anna. "Molecular Analysis of Normal Human Skin and Basal Cell Carcinoma Using Microdissection Based Methods". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5795.
Pełny tekst źródłaBladen, John Christopher. "Identification of genetic factors involved in morphoeic basal cell and sebaceous gland carcinoma of human eyelid tumours with a view to identifying potential treatment targets". Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/25807.
Pełny tekst źródłaMatas, Nadal Clara. "Carcinomes de queratinòcits: aspectes epidemiològics a Catalunya i caracterització proteica del seu fluid intersticial tumoral". Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/672236.
Pełny tekst źródłaIntroducción: Los carcinomas de queratinocitos (CQ) son la neoplasia maligna más frecuente a nivel mundial en poblaciones caucásicas. En conjunto, suponen un enorme problema de salud, tanto en términos de morbilidad como de gasto sanitario. En las últimas décadas, su incidencia ha aumentado de manera significativa. Además, en el carcinoma basocelular (CBC), han aumentado dramáticamente los casos entre la gente joven, sobre todo mujeres. Los CQ tienen, en general, un buen pronóstico. A pesar de ello, el CBC puede crecer localmente destruyendo los tejidos circundantes y causar importantes secuelas funcionales y estéticas, y el carcinoma escamoso (CEC) es moderadamente invasivo y se puede asociar a un riesgo sustancial de recurrencias locales, metástasis y muerte (1.5-4 %). La fisiopatología de los CQ es dependiente de la alteración de varias vías de transducción de señales y de control de la proliferación. Uno de los efectos de estas alteraciones es la secreción de nuevas proteínas en el espacio extracelular, que caracterizarán el microambiente tumoral. Las proteínas y metabolitos señalizadores presentes en el fluido intersticial que rodea el tumor (TIF) han sido estudiados en algunos tipos tumorales, pero no hay nada descrito en cuanto a CQ. Objetivos: Esta tesis tiene dos objetivos principales: 1) Estudio epidemiológico y de factores de riesgo del CBC en Cataluña (Capítulo I), y 2) Caracterizar el perfil proteómico del TIF en los CQ y las implicaciones en su fisiopatología (Capítulos II y III). Resultados y conclusiones: En el estudio epidemiológico se ha observado que entre los < 60 años el CBC ya es un tumor que tiene una incidencia mayor en mujeres que en hombres. Los factores de riesgo independientes para el CBC en gente joven son el fototipo cutáneo, la historia familiar de CQ, y la presencia de ≥ 4 quemaduras en la infancia. Además, la presencia de repetidas quemaduras en la infancia es superior entre los casos de CBC en gente joven localizados en zonas cubiertas que entre los localizados en zonas fotoexpuestas. De todos los factores de riesgo, en la población general, el uso de cabinas de bronceado es el único que es más frecuente entre las mujeres que entre los hombres; por lo tanto, la popularización de su uso podría ser la causa de la tendencia a la predominancia femenina del CBC. En la segunda parte de la tesis, primero se ha puesto a punto el método de aislamiento de TIF. La centrifugación a 10 000 g permite obtener una cantidad superior de proteínas extracelulares, mayor sensibilidad y un manejo más rápido y fácil de las muestras, sin implicar un aumento de la lisis celular respecto a los otros métodos. Por estos motivos, la proponemos como método de elección en las muestras de tumores cutáneos. El análisis proteómico muestra que el CBC, el CEC y la piel sana tienen cada uno un perfil específico de proteínas secretadas en su TIF y sugiere la existencia de una diferente respuesta inmunológica del organismo frente al CBC y al CEC. Hemos determinado que la secreción de las proteínas PNP, FABP5, SFN y LAD1 es un perfil propio del CEC, y que están relacionadas con la agresividad tumoral y podrían ser dianas terapéuticas para su tratamiento. Además, el patrón de expresión de FABP5 permite distinguir las zonas diferenciadas de las invasivas en el CEC. También existe una diferente localización celular de la SFN y la LAD1 en la piel sana vs. CEC, que podría estar relacionada con el desarrollo tumoral. Finalmente, la secreción de cornulina es un marcador de CBC y muestra tendencia a asociarse con los subtipos más agresivos.
Introduction: Keratinocyte carcinomas (KC) are the most frequent malignancy in Caucasian populations worldwide. Altogether, they entail a huge health problem, both in terms of morbidity and health costs. In recent decades, their incidence has increased significantly. Moreover, basal cell carcinoma (BCC) cases have increased dramatically among young people, especially women. KC generally have a good prognosis. Despite this, BCC can grow locally, destroying surrounding tissues and causing important functional and aesthetic sequelae; and squamous cell carcinoma (SCC) is moderately invasive and can be associated with a substantial risk of local recurrences, metastasis, and death (1.5- 4 %). The physiopathology of KC depends on the alteration of several signal transduction pathways and proliferation control. One effect of these alterations is the secretion of new proteins in the extracellular space, which will characterize the tumor microenvironment. The signaling proteins and metabolites present in the interstitial fluid surrounding the tumor (TIF) have been studied in some tumor types, but nothing has been described in terms of KC. Objectives: This thesis has two main objectives: 1) Epidemiological and risk factors study of BCC in Catalonia (Chapter I), and 2) Characterization of the proteomic profile of TIF in KC and the implications in their physiopathology (Chapters II and III). Results and conclusions: In the epidemiological study, it has been revealed that, among those <60 years, BCC is already a tumor that has a higher incidence in women than in men. Independent risk factors for BCC in young people are skin phototype, family history of KC, and the presence of ≥ 4 sunburns in childhood. In addition, the presence of repeated sunburns in childhood is higher among BCC cases in young people in covered areas than among those in photo-exposed areas. Of all the risk factors, among the general population, the use of tanning beds is the only one that is more common among women than among men; therefore, the popularization of their use could be the crucial factor for the trend towards the female predominance of BCC. In the second part of the thesis, the TIF isolation method has been first developed. Centrifugation at 10 000 g allows obtaining a higher amount of extracellular proteins, greater sensitivity, and faster and easier handling of the samples, without increasing cell lysis when compared to other methods. For these reasons, we propose it as the method of choice in samples of skin tumors. The proteomic analysis shows that BCC, SCC, and healthy skin each have a specific profile of secreted proteins in their TIF, and suggests the existence of a different immune response of the organism against BCC and SCC. We have determined that the secretion of PNP, FABP5, SFN, and LAD1 proteins is a specific SCC profile, and that they are related to tumor aggressiveness and could be therapeutic targets for its treatment. Furthermore, the expression pattern of FABP5 makes it possible to distinguish differentiated from invasive areas in SCC. There is also a different cellular location of SFN and LAD1 expression in healthy skin vs. SCC, which could be related to tumor development. Finally, cornulin secretion is a BCC marker and tends to associate with the most aggressive subtypes.
Khalil, Tayma. "Basal-like breast cancers : characterization and therapeutic approaches". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112520.
Pełny tekst źródłaMethods. Eight breast cancer cell lines were characterized by immunohistochemistry and western blotting and were treated with both drugs. Response was measured by using the sulphorhodamine B (SRB) assay.
Results. Two out of six basal-like cell lines were sensitive to gefitinib and five of six to dasatinib. BRCA1-related breast cancers were also responsive to dasatinib (three out of four). Moreover, EGFR and caveolin-1 act as markers for dasatinib sensitivity, but do not appear to be the primary targets of this drug. The presence of SRC but not ABL is necessary to achieve a response to dasatinib.
Conclusion. Dasatinib is more effective in the treatment of basal-like breast cancers than gefitinib and acts by inhibiting SRC and other molecules that are yet to be determined.
Evangelou, Dr Georgios. "Molecular effects of topical photodynamic therapy in healthy human skin and basal cell carcinoma". Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493421.
Pełny tekst źródłaElliott, Jane Alannah. "An in vitro study of the potential stromal role in basal cell carcinoma development". Thesis, Queen Mary, University of London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.576917.
Pełny tekst źródłaCheng, Beibei. "Automatic vessel and telangiectases analysis in dermoscopy skin lesion images". Diss., Rolla, Mo. : Missouri University of Science and Technology, 2009. http://scholarsmine.mst.edu/thesis/pdf/Cheng_09007dcc80636a0d.pdf.
Pełny tekst źródłaVita. The entire thesis text is included in file. Title from title screen of thesis/dissertation PDF file (viewed April 13, 2009) Includes bibliographical references (p. 46).
Essers, Brigitte Agnes Bernadette. "Surgical excision and Mohs Micrographic Surgery for basal cell carcinoma an evaluation from different perspectives /". Maastricht : Maastricht : [Maastricht University] ; University Library, Universiteit Maastricht [host], 2008. http://arno.unimaas.nl/show.cgi?fid=11247.
Pełny tekst źródłaLo, Blanche Ka Ki. "CXCR3 signaling effects on the development and immunoregulation of basal cell carcinoma and related neoplasias". Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/41381.
Pełny tekst źródłaBeesley, Jonathan Michael. "Investigation of exon skipping within the GLI15' untranslated region /". [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18918.pdf.
Pełny tekst źródłaEdlund, Karolina. "Microdissection of well defined cell populations for RNA isolation in the analysis of normal human skin and basal cell carcinoma". Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6148.
Pełny tekst źródłaThe human skin provides us with an excellent protective barrier and possesses a remarkable ability of constant renewal. Basal cell carcinoma is the most common type of skin cancer. The aim of this project was to verify results from an earlier study investigating the molecular differences between basal cell carcinoma (BCC) and basal cells of normal human epidermis. In that study microdissection of cell populations from BCC and basal cells of normal epidermis respectively was performed in five cases of confirmed BCC. Following RNA extraction and amplification, a gene expression analysis was performed using a 46 k human cDNA microarray. Comparison of expression profiles showed a differential expression of approximately 300 genes in BCC. An upregulation of signaling pathways previously known to be of importance in BCC development could be observed, as well as a downregulation of differentiation markers, MHC class II molecules, and proteins active in scavenging of oxygen radicals. We wanted to confirm these findings for a number of selected genes, using real time PCR. The focal point of this project was microdissection of cells from BCC and subsequent isolation of RNA. Microdissection based methods offer a possibility of selecting well defined cell populations for further analysis by using a focused laser beam. Initially tests in order to optimize the method were also performed, concerning the dehydration process and choice of slides used in microdissection. Isolation of RNA may, as we experienced, be associated with problems due to destruction of RNA by degrading enzymes.
Lima, Jacqueline Silva Brito [UNESP]. "Expressão de fatores de proliferação e antiapoptóticos em carcinomas basocelulares". Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/148646.
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O carcinoma basocelular (CBC) é a neoplasia maligna mais comum entre os homens e sua incidência está aumentando em nosso meio. Pode se manifestar como lesão nodular, superficial, esclerodermiforme, micronodular e fibroepitelioma de Pinkus. O CBC é um carcinoma de baixa mortalidade, porém com elevada morbidade devido ao potencial destrutivo local e às elevadas taxas de reincidência. As diferenças evolutivas dos diversos tipos de carcinomas basocelulares não são bem definidas. A análise de fatores de proliferação e apoptose pode subsidiar o conhecimento sobre a fisiopatologia e as diferenças evolutivas dessas lesões. A literatura revela a escassez de investigações sobre a expressão diferencial de fatores de proliferação (Ki-67) e relacionados à apoptose (p53, survivina e NF-kB-p105) dos diferentes subtipos de carcinomas basocelulares e ainda tumores recidivados. O objetivo desse estudo é avaliar a expressão de marcadores de proliferação celular e apoptose em carcinomas basocelulares dos tipos nodular, superficial, esclerodermiforme e tumores recidivados. Foram selecionados subtipos histológicos únicos, como forma de tentar compreender o comportamento dos CBCs individualmente. As lâminas desses espécimes foram submetidas ao protocolo de marcação imuno-histoquímica. Foram estudadas 100 amostras, sendo 50 unidades de epiderme normal e as demais distribuídas entre cada subtipo tumoral. O padrão de marcação de cada marcador sobre os diferentes tipos de tecidos foi avaliado a partir de modelos lineares generalizados (GLMs) seguidos de teste post-hoc de Sidak, quando necessário. Foram encontradas diferenças estatisticamente significativas (p<0,01) na imunomarcação de diferentes tipos de tecidos para os marcadores Ki-67, p53 e survivina, mas não para o marcador p105 (p=0,21). O marcador Ki-67 foi mais expresso nos esclerodermiformes que em células da epiderme e nos nodulares. A imunomarcação do p53 foi menos expressa na epiderme que nos subtipos superficiais e nas recidivas, e também menos expressa nos esclerodermiformes que em todos os outros subtipos tumorais. A survivina mostrou uma imunomarcação maior na epiderme em relação aos subtipos tumorais estudados. A comparação entre os diferentes marcadores foi avaliada pelo cieficiente de correlação de Spearman, que detectou uma correlação estatisticamente significativa (p<0,01) entre os marcadores, Ki-67 e p53 na imunomarcação dos subtipos estudados e de células da epiderme, e uma correlação entre Ki-67 e survivina quando consideramos apenas as células tumorais. Neste estudo, a expressão simultânea de marcadores permitiu a identificação de padrões de proliferação e apoptose que individualizaram comportamentos em subtipos de CBCs, em consonância com formas recidivadas, e de forma independente na epiderme. Houve diferentes padrões de correlação entre a expressão dos marcadores dos CBCs e da epiderme.
Basal cell carcinoma (BCC) is the most common malignant neoplasm among men and its incidence is increasing in our country. It can manifest as nodular, superficial, sclerodermiform, micronodular and Pinkus fibroepithelioma lesions. BCC is a low-mortality carcinoma, but with high morbidity due to local destructive potential and high rates of recurrence. The evolutionary differences of the various types of basal cell carcinomas are not well defined. The analysis of proliferation and apoptosis factors may support knowledge about the pathophysiology and evolutionary differences of these lesions. The literature reveals the scarcity of investigations on the differential expression of proliferation factors (Ki-67) and related apoptosis (p53, survivin and NF-kB-p105) of the different subtypes of basal cell carcinomas and recurrent tumors. The aim of this study is to evaluate the expression of markers of cell proliferation and apoptosis in basal cell carcinomas of the nodular, superficial, sclerodermiform and recurrent tumors. Unique histological subtypes were selected as a way to attempt to understand the behavior of individual BCCs. The slides of these specimens were submitted to the immunohistochemical labeling protocol. A total of 100 samples were studied, being 50 normal epidermal units and the others distributed between each tumor subtype. The marking pattern of each marker on the different tissue types was evaluated from generalized linear models (GLMs) followed by Sidak post-hoc test, when necessary. Statiscally significant differences (p<0,01) in the immunostaining of different tissue types were found for the Ki-67, p53 and survivin markers, but not for the p105 marker (p=0,21). The Ki-67 marker was more expressed in sclerodermiform than in epidermal and nodular cells. Immunoblotting of p53 was less expressed in the epidermis than in superficial subtypes and relapses, and also less expressed in sclerodermiform than in all other tumor subtypes. Survivin showed a greater immunostaining in the epidermis with respect to the tumor subtypes studied. The comparison between the diferent markers was evaluated by the Spearman correlation coefficient, which detected a statistically significant correlation (p<0,01) between the markers, Ki-67 and p53 in the immunoblotting of the studied subtypes and epidermal cells, and one correlation between Ki-67 and survivin when we considered only tumor cells. In this study, the simultaneous expression of markers allowed the identification of patterns of proliferation and apoptosis that individualized behaviors in subtypes of BCCs, in consonance with relapsed forms, and independently in the epidermis. There were different patterns of correlation between the expression of BCC and epidermal markers.
Carless, Melanie, i n/a. "Molecular Analysis of Non-Melanoma Skin Cancer". Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20041101.123114.
Pełny tekst źródłaCarless, Melanie. "Molecular Analysis of Non-Melanoma Skin Cancer". Thesis, Griffith University, 2004. http://hdl.handle.net/10072/367527.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Health Sciences
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Larsimont, Jean-Christophe. "Identification of the molecular mechanisms involved in the initiation, invasion and maintenance of basal cell carcinoma". Doctoral thesis, Universite Libre de Bruxelles, 2018. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/271467.
Pełny tekst źródłaDoctorat en Sciences biomédicales et pharmaceutiques (Médecine)
info:eu-repo/semantics/nonPublished
Iannacone, Michelle R. "Case-Control Study of Sunlight Exposure and Cutaneous Human Papillomavirus Seroreactivity in Basal Cell and Squamous Cell Carcinomas of the Skin". Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3164.
Pełny tekst źródłaBianchi, Lucia. "Elucidating the expression pattern and role of the oncogenic GLI transcription factors in basal cell carcinoma". Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/3165.
Pełny tekst źródłaTerstappen, Karin. "Aspects on in vivo imaging techniques for diagnostics of pigmented skin lesions /". Göteborg : Department of Dermatology and Venereology, Institute of Clinical Science, The Sahlgrenska Academy, University of Gothenburg, 2008. http://hdl.handle.net/2077/17794.
Pełny tekst źródłaSandberg, Carin. "Aspects of fluorescence diagnostics and photodynamic therapy in non-melanoma skin cancer /". Göteborg : Department of Dermatology and Venereology, Sahlgrenska University Hospital, Institute of Clinical Sciences, Sahlgrenska Academy University, University of Gothenburg, 2009. http://hdl.handle.net/2077/21192.
Pełny tekst źródłaRamachandran, Sudarshan. "Identification of genetic and host factors associated with clinical phenotypes in patients with cutaneous basal cell carcinoma". Thesis, Keele University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402689.
Pełny tekst źródłaIkram, Mohammed S. "Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems". Thesis, Queen Mary, University of London, 2007. http://qmro.qmul.ac.uk/xmlui/handle/123456789/1527.
Pełny tekst źródłaD’Uva, Gabriele Matteo <1980>. "Stem cell pathways in the basal-like breast carcinoma: the role of beta-catenin and HIF-1alpha". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3429/1/DUva_Gabriele_Matteo_tesi.pdf.
Pełny tekst źródłaD’Uva, Gabriele Matteo <1980>. "Stem cell pathways in the basal-like breast carcinoma: the role of beta-catenin and HIF-1alpha". Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2011. http://amsdottorato.unibo.it/3429/.
Pełny tekst źródłaStuart, Emma, i n/a. "Therapeutic potential of SERM and EGCG drug combinations for the treatment of basal-like breast cancer". University of Otago. Department of Pharmacology & Toxicology, 2009. http://adt.otago.ac.nz./public/adt-NZDU20090708.090405.
Pełny tekst źródłaChen, Andrew Chih-Chieh. "Effect of oral nicotinamide on non-melanoma skin cancer and skin barrier function". Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15831.
Pełny tekst źródłaCintra, Juliana de Andrade. "Invasão orbitária por carcinoma basocelular palpebral: epidemiologia, fatores clínicos, histopatologia e perfil imuno-histoquímico dos casos submetidos à exenteração em um hospital de referência". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17143/tde-06012017-140841/.
Pełny tekst źródłaBasal cell carcinoma (BCC) is a malignant skin cancer of low metastasizing potential originated from the basal cells of the epidermis. Its clinical and epidemiological importance is evidenced by the fact that it is the most common malignancy in humans and it has as the main etiological factor the exposure to ultraviolet radiation. Despite the low incidence of metastases, the cancer can adopt a locally aggressive behavior with involvement of deep structures and it can have a strong aesthetic appeal, as in the periocular region. One of the complications arising from its infiltration in this anatomical site consists of orbital tissue invasion whose treatment is exenteration, a mutilating procedure consisting of the removal of the eyeball and the soft tissue of the affected orbit. The aim of this study was to evaluate the cases of BCC with orbital invasion that underwent exenteration at the Clinics Hospital of Ribeirão Preto Medical School, University of Sao Paulo, from 1992 through 2012, for possible identification of clinical and morphological factors that can predict an unfavorable evolution of the tumor. The clinical data were obtained from the patients\' charts and we have reviewed all the slides from exenteration specimens and performed immunohistochemical studies with p53, bcl-2, smooth muscle actin and metalloproteinase-1(MMP-1). The control group consisted of age-matched patients with eyelid basal cell carcinomas without orbital invasion. For cases with orbital invasion the number of positive cases labeled for p53 (0.21) and actin (0.21) was significantly lower than the number of positive cases for bcl-2 (0.63) and MMP -1 (0.58) (p = 0.0331). However, the number of positive cases for bcl-2 (0.63) was significantly greater than the proportion of positive cases for MMP-1 (0.58) (p = 0.0126). For cases without orbital invasion the number of positive cases for p53 (0.31) and actin (0.31) was significantly lower than the number of positive cases for bcl-2 (0.63) and MMP-1 (0.50) (p = 0.0273), even though the number of positive cases marked for MMP-1 (0.50) was not significantly different from number of positive cases for bcl-2 (0.63) (p = 0.059). The results indicate that orbital invasion of basal cell carcinoma of the eyelid was more frequent in male sex and that the patients have usually a long history of multiple lesions and were submitted to several procedures. In addition, our results suggest these markers can not predict an aggressive behavior for basal cell carcinomas of the periocular region.