Artykuły w czasopismach: „Anti-aging strategy”

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Gonos, Efstathios S. "Proteasome activation as a novel anti-aging strategy". Free Radical Biology and Medicine 65 (wrzesień 2013): S5. http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.114.

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Gonos, Efstathios. "Proteasome activation as a novel anti-aging strategy". Free Radical Biology and Medicine 75 (październik 2014): S7. http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.842.

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Gonos, S. "THE AGING PROTEASOME AND ITS ACTIVATION AS A NOVEL ANTI-AGING STRATEGY". Innovation in Aging 1, suppl_1 (30.06.2017): 937. http://dx.doi.org/10.1093/geroni/igx004.3362.

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Choudhery, Mahmood S., i David T. Harris. "Cryopreservation can be used as an anti-aging strategy". Cytotherapy 16, nr 12 (grudzień 2014): 1771–73. http://dx.doi.org/10.1016/j.jcyt.2014.08.012.

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Meiliana, Anna, Nurrani Mustika Dewi i Andi Wijaya. "In Search for Anti-Aging Strategy: Can We Rejuvenate Our Aging Stem Cells?" Indonesian Biomedical Journal 7, nr 2 (1.08.2015): 57. http://dx.doi.org/10.18585/inabj.v7i2.72.

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BACKGROUND: Recent evidence suggested that we grow old partly because of our stem cells grow old as a result of mechanisms that suppress the development of cancer over a lifetime. We believe that a further, more precise mechanistic understanding of this process will be required before this knowledge can be translated into human anti-aging therapies.CONTENT: A diminished capacity to maintain tissue homeostasis is a central physiological characteristic of aging. As stem cells regulate tissue homeostasis, depletion of stem cell reserves and/or diminished stem cell function have been postulated to contribute to aging. It has further been suggested that accumulated DNA damage could be a principal mechanism underlying age-dependent stem cell decline. It is interesting that many of the rejuvenating interventions act on the stem cell compartments, perhaps reflecting shared genetic and biochemical pathways controlling stem cell function and longevity. Strategy to slow down the aging processes is based on caloric restriction refers to a dietary regimen low in calories but without undernutrition. Sirtuin (SIRT)1 and 3, increases longevity by mimicking the beneficial effects of caloric restriction. SIRT3 regulates stress-responsive mitochondrial homeostasis, and more importantly, SIRT3 upregulation rejuvenates aged stem cells in tissues. Resveratrol (3,5,4’-trihydroxystilbene), a natural polyphenol found in grapes and wine, was the most powerful natural activator of SIRT1. In fact, resveratrol treatment has been demonstrated to rescue adult stem cell decline, slow down bodyweight loss, improve trabecular bone structure and mineral density, and significantly extend lifespan.SUMMARY: Tissue-specific stem cells persist throughout the entire lifespan to repair and maintain tissues, but their self-renewal and differentiation potential become dysregulated with aging. Given that adult stem cells are thought to be central to tissue maintenance and organismal survival, SIRT3 may promote organismal longevity by maintaining the integrity of tissue-speciic stem cells.KEYWORDS: rejuvenation, aging, stem cell, DNA damage, sirtuin activator

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Lee, Yun Haeng, Ji Yun Park, Haneur Lee, Eun Seon Song, Myeong Uk Kuk, Junghyun Joo, Sekyung Oh, Hyung Wook Kwon, Joon Tae Park i Sang Chul Park. "Targeting Mitochondrial Metabolism as a Strategy to Treat Senescence". Cells 10, nr 11 (3.11.2021): 3003. http://dx.doi.org/10.3390/cells10113003.

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Mitochondria are one of organelles that undergo significant changes associated with senescence. An increase in mitochondrial size is observed in senescent cells, and this increase is ascribed to the accumulation of dysfunctional mitochondria that generate excessive reactive oxygen species (ROS). Such dysfunctional mitochondria are prime targets for ROS-induced damage, which leads to the deterioration of oxidative phosphorylation and increased dependence on glycolysis as an energy source. Based on findings indicating that senescent cells exhibit mitochondrial metabolic alterations, a strategy to induce mitochondrial metabolic reprogramming has been proposed to treat aging and age-related diseases. In this review, we discuss senescence-related mitochondrial changes and consequent mitochondrial metabolic alterations. We assess the significance of mitochondrial metabolic reprogramming for senescence regulation and propose the appropriate control of mitochondrial metabolism to ameliorate senescence. Learning how to regulate mitochondrial metabolism will provide knowledge for the control of aging and age-related pathologies. Further research focusing on mitochondrial metabolic reprogramming will be an important guide for the development of anti-aging therapies, and will provide novel strategies for anti-aging interventions.

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Berezina, T. N., A. V. Litvinova i A. A. Zinatullina. "Interrelation of Individual-Personal Anti-Aging Strategies with Biological Age". Современная зарубежная психология 11, nr 4 (2022): 73–89. http://dx.doi.org/10.17759/jmfp.2022110407.

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<p>The definition of anti-aging is given as a condition that reduces the biological age, improves health or increases life expectancy. Based on the meta-analysis, 13 anti-aging strategies were identified: sports, control, creative, intellectual, subject, altruistic, humor, self-improvement, risk, communication, interaction with nature, achievement, optimism. An empirical study of the effectiveness of these strategies has been carried out. Subjects: persons of retirement age, men — 61—70, women — 56—70 years. The following methods were used: diagnostics of biological age according to Voitenko, questionnaire of personal resources, assessment of individual typological features, correlation analysis. It was found out that the relationship of biological aging with personal resources depends on the socio-demographic characteristics of the individual. Conclusions: to develop an individual-personal anti-aging strategy, it is necessary to take into account the totality of data: gender, age, place of residence, family, children, physique, emotionality, functional asymmetry, interaction style. An effective anti-aging strategy is selected individually for each respondent.</p>

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Ahmed, Amr. "Insulin Sensitizers as Anti-Aging Agents: Unveiling Synergies with Albumin, GLP-1RA, Klotho Protein, and Metformin in the Quest to Combat Aging". Cell & Cellular Life Sciences Journal 9, nr 1 (2024): 1–5. http://dx.doi.org/10.23880/cclsj-16000200.

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This study delves into the synergistic interplay among albumin, insulin, Klotho protein, and relevant medications in the pursuit of a concerted approach to halt aging. Emphasizing albumin's pivotal role in various physiological functions, including transportation and drug distribution, the research underscores its decline's correlation with aging-related cognitive implications. The intricate relationship between insulin and albumin, modulated by Foxo1, underscores its crucial significance. Groundbreaking experiments, utilizing unmodified serum albumin, demonstrate a remarkable increase in lifespan and enhanced physical capabilities, highlighting the potential of an integrative approach. The investigation extends to insulin sensitizers, Klotho protein, metformin, and SGLT2 inhibitors, collectively revealing promising anti-aging effects. The association between Klotho protein and albumin suggests a collaborative mechanism with implications for efficient transport and distribution. This research offers insights into a comprehensive, synergistic strategy harnessing the potential of these elements to counteract aging processes.

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Zimmermann, Andreas, Katharina Kainz, Sebastian J. Hofer, Maria A. Bauer, Sabrina Schroeder, Jörn Dengjel, Federico Pietrocola i in. "Targeting GATA transcription factors – a novel strategy for anti-aging interventions?" Microbial Cell 6, nr 5 (6.05.2019): 212–16. http://dx.doi.org/10.15698/mic2019.05.676.

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Bárcena, Clea, Carlos López-Otín i Guido Kroemer. "Methionine restriction for improving progeria: another autophagy-inducing anti-aging strategy?" Autophagy 15, nr 3 (18.10.2018): 558–59. http://dx.doi.org/10.1080/15548627.2018.1533059.

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Koptyug, Andrey, Yurij Sukhovei, Elena Kostolomova, Irina Unger i Vladimir Kozlov. "Novel Strategy in Searching for Natural Compounds with Anti-Aging and Rejuvenating Potential". International Journal of Molecular Sciences 24, nr 9 (28.04.2023): 8020. http://dx.doi.org/10.3390/ijms24098020.

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We suggest a novel approach for searching natural compounds with anti-aging and rejuvenation potential using cell cultures, with a high potential for the further in vivo applications. The present paper discusses ways of defining age for cell populations with large numbers of cells and suggests a method of assessing how young or old a cell population is based on a cell age profile approach. This approach uses experimental distributions of the cells over the cell cycle stages, acquired using flow cytometry. This paper discusses how such a profile should evolve under homeostatic maintenance of cell numbers in the proliferation niches. We describe promising results from experiments on a commercial substance claiming rejuvenating and anti-aging activity acting upon the cultures of human mononuclear cells and dermal fibroblasts. The chosen substance promotes a shift towards larger proportion of cells in synthesis and proliferation stages, and increases cell culture longevity. Further, we describe promising in vivo testing results of a selected food supplement. Based on the described concept of cell age profile and available test results, a strategy to search for natural compounds with regenerative, anti-aging and rejuvenation potential is suggested and proposed for wider and thorough testing. Proposed methodology of age assessment is rather generic and can be used for quantitative assessment of the anti-aging and rejuvenation potential of different interventions. Further research aimed at the tests of the suggested strategy using more substances and different interventions, and the thorough studies of molecular mechanisms related to the action of the substance used for testing the suggested search methodology, are needed.

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Baramiya, Mamuka, i Sergiy Mykhalskiy. "From geroprotective tactics to anti-ageing strategy: ways to eliminate ageing per se". Issue 2 2023, nr 2 2023 (19.07.2023): 35–44. http://dx.doi.org/10.47855/jal9020-2023-2-2.

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There are two solutions to the ageing problem – tactical and strategic. The tactical solution is to dampen the involution as much as possible to delay the onset and slow down the progression of involution and age-related pathologies. The strategic solution is to eliminate ageing per se (and therefore age-related diseases) through the elimination of the prime cause of ageing. These two approaches are discussed. ___________________________________________________________________________________________ Keywords: aging; anti-aging; geroprotection; carcinogenesis; re-ontogenesis; re-morphogenesis.

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Li, Kai-Juan, Chen Wang, Ting-Ting Zheng, Fuchun Zhao, Ming-Chao Luo i Shuangquan Liao. "Towards high performance anti-aging diolefin elastomers based on structure healing strategy". Polymer 186 (styczeń 2020): 122076. http://dx.doi.org/10.1016/j.polymer.2019.122076.

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Ingram, D. K., i G. S. Roth. "Diet Restriction and Diet Restriction Mimetics: An anti-aging strategy for canines?" Journal of Veterinary Behavior 5, nr 3 (maj 2010): 158. http://dx.doi.org/10.1016/j.jveb.2009.12.011.

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杨, 白玉. "Anti “Digital Abandonment”: Design Strategy for Aging Friendly Online Shopping Interaction Interface". Design 08, nr 04 (2023): 2098–104. http://dx.doi.org/10.12677/design.2023.84251.

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Guo, Xiaohui, Yuanfang Luo, Yongjun Chen, Lijuan Chen i Demin Jia. "Novel Hybrid Biomass Anti-Aging Filler for Styrene-Butadiene Rubber Composites with Antioxidative and Reinforcing Properties". Materials 13, nr 18 (11.09.2020): 4045. http://dx.doi.org/10.3390/ma13184045.

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Antioxidants are normally utilized to extend the service life of polymers due to the strong reducibility of the phenolic hydroxyl group of the hindered phenol structure. Inspired by this characteristic, we have introduced green tea polyphenol (TP) supported on a silica surface containing considerable phenolic hydroxyl groups to obtain a novel biomass anti-aging filler (BAF, denoted as silica-s-TP) to reinforce and improve the anti-aging property of rubber composites. The applying of silica-s-TP to enhance the thermal-oxidative stability and ultraviolet light (UV) aging resistance of styrene-butadiene rubber (SBR) was evaluated. The hybrid biomass anti-aging filler could not only uniformly disperse in the rubber matrix, giving rise to the excellent mechanical properties, but also enhance the properties of thermal-oxidative stability and UV aging resistance with the increasing silica-s-TP content of SBR distinctly. This study provides a mild and environmentally friendly strategy to prepare the functional biomass filler, which could be applied as not only a reinforcement filler but also an anti-aging additive in “green rubber”.

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Kruglikov, Ilja L., i Werner Sontag. "Ultrasound of 10MHz frequency as a novel strategy for skin anti-aging therapy". Medical Hypotheses 74, nr 3 (marzec 2010): 620–21. http://dx.doi.org/10.1016/j.mehy.2009.10.048.

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Novotná, Renáta, Denisa Škařupová, Jiří Hanyk, Jitka Ulrichová, Vladimír Křen, Pavla Bojarová, Katerina Brodsky, Jitka Vostálová i Jana Franková. "Hesperidin, Hesperetin, Rutinose, and Rhamnose Act as Skin Anti-Aging Agents". Molecules 28, nr 4 (11.02.2023): 1728. http://dx.doi.org/10.3390/molecules28041728.

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Aging is a complex physiological process that can be accelerated by chemical (high blood glucose levels) or physical (solar exposure) factors. It is accompanied by the accumulation of altered molecules in the human body. The accumulation of oxidatively modified and glycated proteins is associated with inflammation and the progression of chronic diseases (aging). The use of antiglycating agents is one of the recent approaches in the preventive strategy of aging and natural compounds seem to be promising candidates. Our study focused on the anti-aging effect of the flavonoid hesperetin, its glycoside hesperidin and its carbohydrate moieties rutinose and rhamnose on young and physiologically aged normal human dermal fibroblasts (NHDFs). The anti-aging activity of the test compounds was evaluated by measuring matrix metalloproteinases (MMPs) and inflammatory interleukins by ELISA. The modulation of elastase, hyaluronidase, and collagenase activity by the tested substances was evaluated spectrophotometrically by tube tests. Rutinose and rhamnose inhibited the activity of pure elastase, hyaluronidase, and collagenase. Hesperidin and hesperetin inhibited elastase and hyaluronidase activity. In skin aging models, MMP-1 and MMP-2 levels were reduced after application of all tested substances. Collagen I production was increased after the application of rhamnose and rutinose.

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He, Xin, Xinyu Gao i Weidong Xie. "Research Progress in Skin Aging, Metabolism, and Related Products". International Journal of Molecular Sciences 24, nr 21 (3.11.2023): 15930. http://dx.doi.org/10.3390/ijms242115930.

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In recent years, skin aging has received increasing attention. Many factors affect skin aging, and research has shown that metabolism plays a vital role in skin aging, but there needs to be a more systematic review. This article reviews the interaction between skin metabolism and aging from the perspectives of glucose, protein, and lipid metabolism and explores relevant strategies for skin metabolism regulation. We found that skin aging affects the metabolism of three major substances, which are glucose, protein, and lipids, and the metabolism of the three major substances in the skin also affects the process of skin aging. Some drugs or compounds can regulate the metabolic disorders mentioned above to exert anti-aging effects. Currently, there are a variety of products, but most of them focus on improving skin collagen levels. Skin aging is closely related to metabolism, and they interact with each other. Regulating specific metabolic disorders in the skin is an important anti-aging strategy. Research and development have focused on improving collagen levels, while the regulation of other skin glycosylation and lipid disorders including key membrane or cytoskeleton proteins is relatively rare. Further research and development are expected.

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Ogita, Akira, Wakae Murata, Ken Yamauchi, Akiko Sakai, Yoshihiro Yamaguchi, Toshio Tanaka i Ken-ichi Fujita. "Immature Pear Extract Constituents Exert Multifaceted Anti-aging Effects". Innovation in Aging 5, Supplement_1 (1.12.2021): 679. http://dx.doi.org/10.1093/geroni/igab046.2556.

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Abstract Cellular senescence causes a gradual loss of physiological functions and induces chronic diseases, which negatively affect the quality of human life. Intervention in the cellular senescence process may reduce the incidence of these diseases while delaying the progression of age-related diseases, thereby prolonging human lifespan. In our previous study, we found that extending the chronological lifespan of budding yeast cells, a suitable cellular model for research on mammalian cells, could be achieved by adding immature pear extract (iPE). Moreover, at the 2020 GSA meeting, using a colony-counting method, we reported that both hydrophilic (WiPE) and hydrophobic (OiPE) iPE components exhibited a chronological lifespan prolongation on yeast cells. In this study, the expression of sirtuin-related genes, which regulate cellular senescence, was verified by quantitative real-time reverse-transcription polymerase chain reaction. Interestingly, sirtuin-related gene expression was significantly increased in the WiPE-treated cells only, and OiPE could extend the chronological lifespan of yeast cells through the mechanisms not involved in sirtuin-related gene expression. In general, hydrophobic and hydrophilic components exhibit different degradation and metabolism in cells. Since each component has a different strategy of absorption and excretion in the body, we hypothesize that iPE with multiple active components will have multifaceted effects on anti-aging. Our research on elucidating the mechanism of lifespan extension by OiPE and its application to mammalian cells is ongoing.

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Rosalia, Yesi, i I. Wayan Juli Sumadi. "Intermittent Fasting as New Approaches as Anti Aging for Preventing Age-associated Diseases". Jurnal Penelitian Pendidikan IPA 9, nr 11 (25.11.2023): 1178–88. http://dx.doi.org/10.29303/jppipa.v9i11.5492.

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The aging process is inherently linked to an increased susceptibility to various chronic conditions, such as cardiovascular diseases, diabetes, and neurodegenerative disorders. The aim of this research is to delves into the current body of knowledge surrounding intermittent fasting and its potential implications in preventing age-related diseases. The methodological approach used in this research is systematic review. Research search using PRISMA strategy by searching journal articles from various databases including Scopus, Proquest, Science Direct, CINAHL, and Google Scholar in the last five years from 2019 to 2023. The results of PRISMA found 333 articles identified through the five databases contained in research methods and screened through titles. Result this research is the promising role of intermittent fasting in promoting anti-aging effects and preventing age-associated diseases through its multifaceted influence on cellular and molecular mechanisms. As an innovative avenue, intermittent fasting holds the potential to revolutionize strategies aimed at enhancing healthy aging and longevity. intermittent fasting as new approaches as anti aging for preventing age-associated diseases

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Kalmukova, Olesia, Vitalii Kyryk i Mykola Dzerzhynsky. "CIRCADIAN RHYTHMS AND PERSONALIZED STRATEGIES FOR ANTI-AGING THERAPIES". Anti-Aging Eastern Europe 1, nr 1 (28.06.2022): 19–27. http://dx.doi.org/10.56543/aaeeu.2022.1.1.03.

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Background. Nowadays personalized medicine is actively developing and consists of individual approaches during patients' treatment, diagnoses and prognoses. Since the first use of DNA sequence analysis in 2009, many other directions and methods for precision medicine have been proposed, including metabolome, transcriptome, proteome, microbiome analysis etc., which reflect internal factors of organisms. Moreover, to take into account environmental influence on organisms including day/night activity, feeding and physical training regime, it was proposed to apply the descriptions of circadian system rhythmicity of each patient. Also, with organism aging, the sensitivity to external factors is raised that emphasizes the importance of the chronobiological approach in anti-aging concept. In this review we discussed available ways of the application of circadian system parameters to analyze human metabolic state. Methods. Search strategy: PubMed, Scopus, DOAJ (Directory of Open Access Journals) and Google Scholar were used to search for original research and articles review; no abstracts from meeting reports have been cited. ClinicalTrials.gov was used to search for clinical studies. Search terms included “chronotherapy”, “circadian system”, and “chronobiology”. Results. According to personalized medicine, the analysis of circadian system in the case of each patient is necessary as circadian rhythmicity varies in every person. Taking into account the peculiarities of patient’s circadian system it will be easy to choose the best time for drug administration resulting in high efficacy and low side effects. The analysis of circadian system can be performed on molecular, physiological and systemic (general, metabolic and inflammation markers) levels. There was shown the increase in the number of clinical trials which are based on the use of chronobiological approach during the treatment of different pathologies that increase with aging: depression, insomnia, metabolic and cardiovascular disease, cancer. More than 1,000 clinical trials involving circadian interventions and chronobiology have been registered worldwide. Conclusion. Chronobiological approach can be used as an additional measure to anti-aging therapy to diagnose metabolic state, to choose more effective treatment time as well as in preventive healthcare in terms of personalized medicine.

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Beck, Samuel, Jun-Yeong Lee i Jarod Rollins. "In silico identification of anti-aging pharmaceutics from community knowledge". Innovation in Aging 5, Supplement_1 (1.12.2021): 672. http://dx.doi.org/10.1093/geroni/igab046.2533.

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Abstract In this era of Big Data, the volume of biological data is growing exponentially. Systematic profiling and analysis of these data will provide a new insight into biology and human health. Among diverse types of biological data, gene expression data closely mirror both the static phenotypes and the dynamic changes in biological systems. Drug-to-drug or drug-to-disease comparison of gene expression signature allows repurposing/repositioning of existing pharmaceutics to treat additional diseases that, in turn, provides a rapid and cost-effective approach for drug discovery. Thanks to technological advances, gene expression profiling by mRNA-seq became a routine tool to address all aspects of the problem in modern biological research. Here, we present how drug repositioning using published mRNA-seq data can provide unbiased and applicable pharmaco-chemical intervention strategies to human diseases and aging. In specifics, we profiled over a half-million gene expression profiling data generated from various contexts, and using this, we screened conditions that can suppress age-associated gene expression changes. As a result, our analysis identified various previously validated aging intervention strategies as positive hits. Furthermore, our analysis also predicted a novel group of chemicals that has not been studied from an aging context, and this indeed significantly extended the life span in model animals. Taken together, our data demonstrate that our community knowledge-guided in silico drug-discovery pipeline provides a useful and effective tool to identify the novel aging intervention strategy.

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Aragonès, Gemma, Sheldon Rowan, Sarah G. Francisco, Elizabeth A. Whitcomb, Wenxin Yang, Giuliana Perini-Villanueva, Casper G. Schalkwijk, Allen Taylor i Eloy Bejarano. "The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy". Cells 10, nr 8 (22.07.2021): 1852. http://dx.doi.org/10.3390/cells10081852.

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The glyoxalase system is critical for the detoxification of advanced glycation end-products (AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of biomolecules by sugars or their metabolites through a process called glycation. AGEs have adverse effects on many tissues, playing a pathogenic role in the progression of molecular and cellular aging. Due to the age-related decline in different anti-AGE mechanisms, including detoxifying mechanisms and proteolytic capacities, glycated biomolecules are accumulated during normal aging in our body in a tissue-dependent manner. Viewed in this way, anti-AGE detoxifying systems are proposed as therapeutic targets to fight pathological dysfunction associated with AGE accumulation and cytotoxicity. Here, we summarize the current state of knowledge related to the protective mechanisms against glycative stress, with a special emphasis on the glyoxalase system as the primary mechanism for detoxifying the reactive intermediates of glycation. This review focuses on glyoxalase 1 (GLO1), the first enzyme of the glyoxalase system, and the rate-limiting enzyme of this catalytic process. Although GLO1 is ubiquitously expressed, protein levels and activities are regulated in a tissue-dependent manner. We provide a comparative analysis of GLO1 protein in different tissues. Our findings indicate a role for the glyoxalase system in homeostasis in the eye retina, a highly oxygenated tissue with rapid protein turnover. We also describe modulation of the glyoxalase system as a therapeutic target to delay the development of age-related diseases and summarize the literature that describes the current knowledge about nutritional compounds with properties to modulate the glyoxalase system.

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Fraile, Maria, Noemi Eiro, Luis A. Costa, Arancha Martín i Francisco J. Vizoso. "Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies". Biology 11, nr 11 (18.11.2022): 1678. http://dx.doi.org/10.3390/biology11111678.

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Aging and frailty are complex processes implicating multifactorial mechanisms, such as replicative senescence, oxidative stress, mitochondrial dysfunction, or autophagy disorder. All of these mechanisms drive dramatic changes in the tissue environment, such as senescence-associated secretory phenotype factors and inflamm-aging. Thus, there is a demand for new therapeutic strategies against the devastating effects of the aging and associated diseases. Mesenchymal stem cells (MSC) participate in a “galaxy” of tissue signals (proliferative, anti-inflammatory, and antioxidative stress, and proangiogenic, antitumor, antifibrotic, and antimicrobial effects) contributing to tissue homeostasis. However, MSC are also not immune to aging. Three strategies based on MSC have been proposed: remove, rejuvenate, or replace the senescent MSC. These strategies include the use of senolytic drugs, antioxidant agents and genetic engineering, or transplantation of younger MSC. Nevertheless, these strategies may have the drawback of the adverse effects of prolonged use of the different drugs used or, where appropriate, those of cell therapy. In this review, we propose the new strategy of “Exogenous Restitution of Intercellular Signalling of Stem Cells” (ERISSC). This concept is based on the potential use of secretome from MSC, which are composed of molecules such as growth factors, cytokines, and extracellular vesicles and have the same biological effects as their parent cells. To face this cell-free regenerative therapy challenge, we have to clarify key strategy aspects, such as establishing tools that allow us a more precise diagnosis of aging frailty in order to identify the therapeutic requirements adapted to each case, identify the ideal type of MSC in the context of the functional heterogeneity of these cellular populations, to optimize the mass production and standardization of the primary materials (cells) and their secretome-derived products, to establish the appropriate methods to validate the anti-aging effects and to determine the most appropriate route of administration for each case.

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El Maï, Mounir, Serena Janho dit Hreich, Cedric Gaggioli, Armelle Roisin, Nicole Wagner, Jing Ye, Pierre Jalinot, Julien Cherfils-Vicini i Eric Gilson. "A Novel Screen for Expression Regulators of the Telomeric Protein TRF2 Identified Small Molecules That Impair TRF2 Dependent Immunosuppression and Tumor Growth". Cancers 13, nr 12 (15.06.2021): 2998. http://dx.doi.org/10.3390/cancers13122998.

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Telomeric repeat-binding factor 2 (TRF2) is a subunit of the shelterin protein complex, which binds to and protects telomeres from unwanted DNA damage response (DDR) activation. TRF2 expression plays a pivotal role in aging and cancer, being downregulated during cellular senescence and overexpressed during oncogenesis. Cancers overexpressing TRF2 often exhibit a poor prognosis. In cancer cells, TRF2 plays multiple functions, including telomere protection and non-cell autonomous roles, promoting neo-angiogenesis and immunosuppression. We present here an original screening strategy, which enables identification of small molecules that decrease or increase TRF2 expression. By screening a small library of Food and Drug Agency (FDA)-approved drugs, we identified two molecules (AR-A014418 and alexidine·2HCl) that impaired tumor growth, neo-angiogenesis and immunosuppression by downregulating TRF2 expression in a mouse xenograft model. These results support the chemotherapeutic strategy of downregulating TRF2 expression to treat aggressive human tumors and validate this cell-based assay capable of screening for potential anti-cancer and anti-aging molecules by modulating TRF2 expression levels.

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Georgiev, Tsvetoslav, i Plamena Kabakchieva. "METFORMIN AS A PROMISING ANTI-AGING AGENT IN THE TREATMENT OF OSTEOARTHRITIS". Anti-Aging Eastern Europe 1, nr 2 (28.12.2022): 113–17. http://dx.doi.org/10.56543/aaeeu.2022.1.2.05.

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Osteoarthritis (OA) is traditionally considered an age-related disease. Therefore, repurposing drugs with the potential to reduce cell senescence is a justified therapeutic strategy. Such is the case of metformin, the most widely used antidiabetic medicine with well-known pharmacokinetics, acceptable toxicity, and beneficial metabolic effects. Metformin could significantly impact processes associated with aging and OA such as cellular senescence, infammaging, mitochondrial dysfunction and impaired nutrient sensing. The aim of the present narrative review is to unveil the potential of metformin to modify disease course in light of aging osteoarthritic joints. The drug has pleiotropic effects on chondrocyte and extracellular matrix metabolism and may provide through AMPK-dependent and -independent pathways a meaningful improvement of OA. Mostly preclinical and retrospective cohort studies have shown that metformin exposure could lead to the regulation of cartilage homeostasis, symptomatic relief of pain and postpone surgery for those suffering from OA. Randomized control trials are warranted to justify the preliminary expectations.

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Melo Pereira, Sofia, Rui Ribeiro i Elsa Logarinho. "Approaches towards Longevity: Reprogramming, Senolysis, and Improved Mitotic Competence as Anti-Aging Therapies". International Journal of Molecular Sciences 20, nr 4 (21.02.2019): 938. http://dx.doi.org/10.3390/ijms20040938.

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Mainstream approaches that are currently used as anti-aging therapies primarily explore the senescence and epigenetic drift aging hallmarks and they are at two ends of the spectrum. While senolytic therapies include either the selective elimination of senescent cells or the disruption of their secretome with the use of drugs or natural compounds, cellular reprogramming uses genetic manipulation to revert cells all the way back to pluripotency. Here, we describe the progress that has been made on these therapies, while highlighting the major challenges involved. Moreover, based on recent findings elucidating the impact of mitotic shutdown and aneuploidy in cellular senescence, we discuss the modulation of mitotic competence as an alternative strategy to delay the hallmarks of aging. We propose that a regulated rise in mitotic competence of cells could circumvent certain limitations that are present in the senolytic and reprogramming approaches, by acting to decelerate senescence and possibly restore the epigenetic landscape.

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Zhang, Yu, Jian Zheng, Wanli Ma, Xiao Zhang, Yongqiang Du, Ke Li, Yahao Liu, Guibo Yu i Yunfei Jia. "Wide-temperature-range and anti-aging self-healing polyurethane enabled by dual cooperative cross-linking strategy". Express Polymer Letters 17, nr 3 (2023): 252–67. http://dx.doi.org/10.3144/expresspolymlett.2023.19.

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Faria, Alessandra V. S., Sheila S. Andrade, Maikel P. Peppelenbosch, Carmen V. Ferreira-Halder i Gwenny M. Fuhler. "Platelets in aging and cancer—“double-edged sword”". Cancer and Metastasis Reviews 39, nr 4 (1.09.2020): 1205–21. http://dx.doi.org/10.1007/s10555-020-09926-2.

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AbstractPlatelets control hemostasis and play a key role in inflammation and immunity. However, platelet function may change during aging, and a role for these versatile cells in many age-related pathological processes is emerging. In addition to a well-known role in cardiovascular disease, platelet activity is now thought to contribute to cancer cell metastasis and tumor-associated venous thromboembolism (VTE) development. Worldwide, the great majority of all patients with cardiovascular disease and some with cancer receive anti-platelet therapy to reduce the risk of thrombosis. However, not only do thrombotic diseases remain a leading cause of morbidity and mortality, cancer, especially metastasis, is still the second cause of death worldwide. Understanding how platelets change during aging and how they may contribute to aging-related diseases such as cancer may contribute to steps taken along the road towards a “healthy aging” strategy. Here, we review the changes that occur in platelets during aging, and investigate how these versatile blood components contribute to cancer progression.

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Ma, Mingyang, Huiling Zeng, Pei Yang, Jiabing Xu, Xingwang Zhang i Wei He. "Drug Delivery and Therapy Strategies for Osteoporosis Intervention". Molecules 28, nr 18 (16.09.2023): 6652. http://dx.doi.org/10.3390/molecules28186652.

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With the advent of the aging society, osteoporosis (OP) risk increases yearly. Currently, the clinical usage of anti-OP drugs is challenged by recurrent side effects and poor patient compliance, regardless of oral, intravenous, or subcutaneous administration. Properly using a drug delivery system or formulation strategy can achieve targeted drug delivery to the bone, diminish side effects, improve bioavailability, and prolong the in vivo residence time, thus effectively curing osteoporosis. This review expounds on the pathogenesis of OP and the clinical medicaments used for OP intervention, proposes the design approach for anti-OP drug delivery, emphatically discusses emerging novel anti-OP drug delivery systems, and enumerates anti-OP preparations under clinical investigation. Our findings may contribute to engineering anti-OP drug delivery and OP-targeting therapy.

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Wei, Juntong, He Qi, Keke Liu, Changsheng Zhao, Yan Bian i Guorong Li. "Effects of Metformin on Life Span, Cognitive Ability, and Inflammatory Response in a Short-Lived Fish". Journals of Gerontology: Series A 75, nr 11 (3.05.2020): 2042–50. http://dx.doi.org/10.1093/gerona/glaa109.

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Abstract Metformin, an oral antidiabetic drug, prolongs the life span in nematode, silkworm, and other transgenic rodents, but its effects on longevity and aging-related cognitive ability using natural aging vertebrate models remain poorly understood. The genus of annual fish Nothobranchius show accelerated growth and expression of aging biomarkers. Here, using the short-lived fish Nothobranchius guentheri, we investigated effects of metformin on life span and aging-related cognitive ability and inflammation. Total of 145 fish, 72 fish were fed with metformin in the concentration of 2 mg/g food and 73 fish without metformin from 16 weeks of age until the end of their lives. The chronic feeding with metformin prolonged the life span of the fish and delayed aging with retarded accumulation of lipofuscin in liver, senescence-associated beta-galactosidase (SA-β-gal) activity in skin and serum levels of cholesterol and triglyceride significantly in the 10-month-old fish. Furthermore, metformin improved motor, learning, and memory skills by behavior tests accompanying with reduction of SA-β-gal activity and neurofibrillary degeneration and inhibition of inflammatory response including downregulated NF-κB and proinflammatory cytokines IL-8, TNF-α, and IL-1β expression and enhanced anti-inflammatory cytokine IL-10 level in brain. These findings demonstrate that metformin prolongs the life span and exerts neuroprotective and anti-inflammation function to improve cognitive ability in annual fish. It might be an effective strategy by using metformin to raise the possibility of promoting healthy aging of old population in aging process.

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Lyu, Jia-Ling, Yi-Jung Liu, Kuo-Ching Wen, Chen-Yuan Chiu, Yung-Hsiang Lin i Hsiu-Mei Chiang. "Protective Effect of Djulis (Chenopodium formosanum) Extract against UV- and AGEs-Induced Skin Aging via Alleviating Oxidative Stress and Collagen Degradation". Molecules 27, nr 7 (4.04.2022): 2332. http://dx.doi.org/10.3390/molecules27072332.

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Skin aging is a complex process involving photoaging and glycation stress, which share some fundamental pathways and have common mediators. They can cause skin damage and collagen degradation by inducing oxidative stress and the accumulation of reactive oxygen species (ROS). Chenopodium formosanum (CF), also known as Djulis, is a traditional cereal in Taiwan. This study investigated the protection mechanisms of CF extract against ultraviolet (UV) radiation and advanced glycation end products (AGEs)-induced stress. The results indicated that CF extract had strong antioxidant and free radical scavenging effects. It could reduce UV-induced intracellular ROS generation and initiate the antioxidant defense system by activating the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway in human skin fibroblasts. CF extract modulated mitogen-activated protein kinase (MAPK) and transformed growth factor-beta (TGF-β) signaling pathways to alleviate oxidative stress-induced skin aging. Moreover, the results revealed that CF extract not only promoted collagen synthesis but also improved aging-induced collagen degradation. CF extract attenuated AGEs-induced ROS production and the upregulation of receptor for AGEs (RAGE). The overall results suggest that CF extract provides an effective anti-aging strategy by preventing skin damage from oxidative stress and collagen loss with potent antioxidant, anti-photoaging, and antiglycation activities.

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Nagwani, Amit Kumar, Łukasz Kaczmarek i Hanna Kmita. "Applicable Life-History and Molecular Traits for Studying the Effects of Anhydrobiosis on Aging in Tardigrades". Diversity 14, nr 8 (17.08.2022): 664. http://dx.doi.org/10.3390/d14080664.

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Anhydrobiosis is induced by loss of water and indicates dehydration tolerance. Survival of dehydration is possible through changes at different levels of organism organization, including a remarkable reduction in metabolic activity at the cellular level. Thus, anhydrobiosis may be regarded as an anti-aging strategy. Accordingly, two hypotheses named after popular stories, “Sleeping Beauty” and “The Picture of Dorian Gray”, were proposed to explain the effect of anhydrobiosis on aging. The two hypotheses predict the presence (The Picture of Dorian Gray) or absence (Sleeping Beauty) of observable aging symptoms for animals undergoing anhydrobiosis. Predictions of these hypotheses have rarely been tested, and the cellular level has not been addressed. Tardigrades appear to be a useful model for studying the effect of anhydrobiosis on aging, as they are able to enter and survive anhydrobiosis at any stage of life, although not with the same success for all species. In this review, we discuss anhydrobiosis and aging mechanisms as well as tardigrade diversity and indicate possible multilevel markers that can be used to study the impact of anhydrobiosis on tardigrade aging. This review provides data on tardigrade diversity that may also be useful for human aging studies.

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MAČIULAITIS, Romualdas, Mindaugas GRIGONIS, Jurgita MALAIŠKIENĖ i Donatas LIPINSKAS. "PECULIARITIES OF DESTRUCTION MECHANISM OF POLYMERIC INTUMESCENT FIRE PROTECTIVE COATINGS". Journal of Civil Engineering and Management 24, nr 2 (20.03.2018): 93–105. http://dx.doi.org/10.3846/jcem.2018.447.

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The article describes the destruction mechanism of intumescent fire protective paint coatings at the time of their aging under the impact of simulated climatic factors. Steel plates covered in anti-corrosion varnishes and intumescent fire protective paint coatings of several types and different composition were used in the research, while certain samples were also additionally covered in protective coatings protecting from environmental effects. SEM, DTA and FT-IR researches were conducted on control samples and samples after aging. Aging was performed in 3 ways: according to regimes I and II in the laboratory and having stored them for 12 months under the outdoor conditions under the roof. The aging mechanism of materials was determined to be very similar when using different methods of aging: with increasing number of cycles, the extent of damage to the surfaces and their diversity increase. In all cases, chemical material changes were observed after artificial aging cycles compared to control samples. In aged samples, there were some new connections occurring, while others changed or disappeared judging from the number of waves and intensity of peaks, which shows that certain compounds form, while others change and disintegrate under the influence of environmental heat and mass exchange.

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Baklaushev, Vladimir P., Ekaterina M. Samoilova, Vladimir A. Kalsin i Gaukhar M. Yusubalieva. "Aging and “rejuvenation” of resident stem cells — a new way to active longevity?" Journal of Clinical Practice 13, nr 1 (15.04.2022): 79–91. http://dx.doi.org/10.17816/clinpract104999.

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This review presents the current data on the methodology for assessing the biological and epigenetic age, describes the concept of the epigenetic clock, and characterizes the main types of resident stem cells and the specifics of their aging. It has been shown that age-related changes in organs and tissues, as well as age-related diseases, are largely due to the aging of resident stem cells. The latter represent an attractive target for cell rejuvenation, as they can be isolated, cultured ex vivo, modified, and re-introduced into the resident niches. Two main methodologies for the cellular rejuvenation are presented: genetic reprogramming with zeroing the age of a cell using transient expression of transcription factors, and various approaches to epigenetic rejuvenation. The close relationship between aging, regeneration, and oncogenesis, and between these factors and the functioning of resident stem cell niches requires further precision studies, which, we are sure, can result in the creation of an effective anti-aging strategy and prolongation of human active life.

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Meunier, Marie, Marine Bracq, Jean Tiguemounine, Giada Maramaldi, Amandine Scandolera i Romain Reynaud. "Skin Cellular Reprogramming as an Innovative Anti-Aging Strategy for Cosmetic Application: A Clinical Study of Sericoside". Frontiers in Bioscience-Landmark 28, nr 6 (12.06.2023): 112. http://dx.doi.org/10.31083/j.fbl2806112.

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Assawavichairoj, Sutthipat, i Mehdi Taghian. "Cross-cultural comparison of consumer pre-purchase decision-making". Asia Pacific Journal of Marketing and Logistics 29, nr 1 (9.01.2017): 27–46. http://dx.doi.org/10.1108/apjml-01-2016-0002.

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Purpose The purpose of this paper is to investigate the cultural differences in female consumers’ motivation to purchase appearance-enhancing products, particularly anti-aging creams. Design/methodology/approach This study uses a qualitative research design to collect the data. Focus group discussions were used. The participants were selected from Thai and Australian females, 25-45 years old in Melbourne representing the most frequent users of anti-aging products. Findings The results indicated variations among participants in their motivation to seek a better appearance. The motivation ranged from a combination of striving to achieve an ideal self and a high level of social acceptability through maintaining youthful appearance and improving on the perceived declining youthful appearance. Using anti-aging products turned out to be a means for taking care of oneself, achieving better social acceptability and improving self-image. These key motivations are inspired by the individual’s social condition and from the reactions they receive from others. These motivations are shared by all participants, but within different cultural perspectives. Research limitations/implications The main limitation is in relation to the true expression of attitudes by respondents, particularly in regard to the discussion of privately held beliefs about self-image, social acceptability and personal appearance. Additionally, the variations between cultural perceptions are only indicative of real differences between collectivist and individualistic cultures. Practical implications Managers can adopt a cultural framework for understanding their consumers’ motivations to enhance their appearance, formulate more accurately their marketing strategy and activate and satisfy their consumers’ demand and better inform their new product developments. Originality/value The analysis explains and compares the differences and similarities in female consumers’ motivations for anti-aging product consumption of two fundamentally different cultural value systems.

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Cheung, Yiu-Ming, Chui-Yiu-Bamboo Chook, Hoi-Wa Yeung, Fung-Ping Leung i Wing-Tak Wong. "A Wrong Fate Decision in Adipose Stem Cells upon Obesity". Cells 12, nr 4 (19.02.2023): 662. http://dx.doi.org/10.3390/cells12040662.

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Progress has been made in identifying stem cell aging as a pathological manifestation of a variety of diseases, including obesity. Adipose stem cells (ASCs) play a core role in adipocyte turnover, which maintains tissue homeostasis. Given aberrant lineage determination as a feature of stem cell aging, failure in adipogenesis is a culprit of adipose hypertrophy, resulting in adiposopathy and related complications. In this review, we elucidate how ASC fails in entering adipogenic lineage, with a specific focus on extracellular signaling pathways, epigenetic drift, metabolic reprogramming, and mechanical stretch. Nonetheless, such detrimental alternations can be reversed by guiding ASCs towards adipogenesis. Considering the pathological role of ASC aging in obesity, targeting adipogenesis as an anti-obesity treatment will be a key area of future research, and a strategy to rejuvenate tissue stem cell will be capable of alleviating metabolic syndrome.

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Inker, Jenny. "Interpreting the Emerging Discourse Around Elderhood: Life Stage, Anti-Ageism Strategy, or Something Else?" Innovation in Aging 5, Supplement_1 (1.12.2021): 496. http://dx.doi.org/10.1093/geroni/igab046.1915.

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Abstract The emerging discourse around elderhood hints at the possibility of a later life stage characterized by a focus on balancing development and decline, with potential to empower elders. However, little agreement exists about whether elderhood is a valid and useful construct. The first presenter questions the aging “mystique” through an analysis of the concepts of elderhood, sageing, croning, and eldering in popular and academic literature, underscoring the importance of avoiding othering and critically thinking beyond labels, even if positive. The second presenter explores the concept of agency in later life through a feminist philosophical lens, arguing that confrontations with one’s existential vulnerability need not be an obstacle to agency in elderhood, but rather can inspire alternative conceptualizations of it. The third presenter contrasts his personal and professional experiences of studying cultural aspects of aging, concluding that elderhood is neither a stage of a life nor a rite of passage but rather an individual, voluntaristic process. The fourth presenter explores 943 texts written by Finnish older adults, finding that the writers creatively position themselves as a group of older persons with a special contribution to make to society, even where elderhood is not explicitly mentioned, and potentially offer an alternative view to countering ageism. The fifth and final presenter explores a novel elderhood video intervention among first-year medical students (N = 585). Thematic findings of neutrality, elderhood as development, elderhood as othering, and elderhood as an opportunity to reframe stigma suggest that elderhood may be a viable and productive anti-ageism strategy.

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Kang, Seongsu, Kyunghoe Kim, Seung-Hyun Jun, Seonju Lee, Juhyun Kim, Joong-Gon Shin, Yunkwan Kim, Mina Kim, Sun-Gyoo Park i Nae-Gyu Kang. "Anti-Irritant Strategy against Retinol Based on the Genetic Analysis of Korean Population: A Genetically Guided Top–Down Approach". Pharmaceutics 13, nr 12 (25.11.2021): 2006. http://dx.doi.org/10.3390/pharmaceutics13122006.

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Retinol, one of the most powerful cosmetic materials for anti-aging supported by a solid scientific background, exhibits a wide range of type and severity of irritation while showing limited user compliance. The lack of understanding of the mechanism of retinol-induced irritation has been the main hurdle in the development of anti-irritation strategies. Here, we identified 30 genetic markers related to the susceptibility to retinol-induced irritation in the Korean population. Based on the genetic analysis, a novel formula against retinol-induced irritation was developed, which mitigated the molecular pathogenesis—as indicated by the genetic markers—of the retinol-induced irritation. In human tests, this formula effectively decreased retinol-induced irritation. Furthermore, a polygenic risk score model for irritation was constructed and validated. Our comprehensive approach for the analysis of retinol-induced irritation will not only aid the development of anti-irritation strategies to ensure higher user compliance but also contribute to improving the current knowledge about the biological effects of retinoids.

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Monnier, V. M., i X. Wu. "Enzymatic deglycation with amadoriase enzymes from Aspergillus sp. as a potential strategy against the complications of diabetes and aging". Biochemical Society Transactions 31, nr 6 (1.12.2003): 1349–53. http://dx.doi.org/10.1042/bst0311349.

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The Amadori compound is the major single modification of the extracellular matrix by the Maillard reaction in vivo. It is also a source of biologically active glycoxidation products and the formation of glucosepane, the major protein cross-link found in biological tissues so far. For this reason, introduction of deglycating enzymes as anti-aging strategy would be desirable. This article provides an update on amadoriase enzymes from fungi which, one day, will hopefully help prevent the in vivo consequences of glycation.

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Ni, Bowei, Wenbin Pei, Yunkun Qu, Rui Zhang, Xiangyu Chu, Yingguang Wang, Xiaojian Huang i Hongbo You. "MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis". Oxidative Medicine and Cellular Longevity 2021 (3.11.2021): 1–14. http://dx.doi.org/10.1155/2021/4139048.

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Osteoarthritis (OA), characterized by chronic systemic low-level inflammation and cartilage degeneration, is a type of arthritis closely associated with aging. Inflammation and aging play a pivotal role in the occurrence and progression of OA. NLRP3 inflammasome is involved in many inflammatory and aging diseases, and NLRP3 inhibitor MCC950 has anti-inflammatory and antisenescence effects on some diseases such as Alzheimer’s disease. In the present study, we found that NLRP3 protein was upregulated in human and mouse OA cartilage. Moreover, NLRP3 and Caspase1 expression induced by IL-1β in chondrocytes was blocked by MCC950. In addition, MCC950 inhibited the expression of inflammatory mediators, matrix-degrading enzymes, senescence marker protein P16 (INK4A), and β-galactosidase, as well as excessive production of ROS. Meanwhile, MCC950 promoted autophagy-related protein expression and autophagy flux under the inflammatory condition. However, autophagy inhibitor 3-MA reversed anti-inflammatory and anticatabolic effects of MCC950. In in vivo experiments, intra-articular administration of MCC950 further showed its protective effect on cartilage degeneration. Bioinformatic analysis and in vitro experimental results revealed that MCC950 might play a protective role in cartilage by regulating Nrf2/HO-1/NQO1, PI3k/Akt/mTOR, P38/MAPK, and JNK/MAPK pathways. In conclusion, our work demonstrated that NLRP3 inhibitor MCC950 might serve as a promising strategy for OA treatment.

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Cheraghian, Goshtasp, Michael P. Wistuba, Sajad Kiani, Ali Behnood, Masoud Afrand i Andrew R. Barron. "Engineered nanocomposites in asphalt binders". Nanotechnology Reviews 11, nr 1 (1.01.2022): 1047–67. http://dx.doi.org/10.1515/ntrev-2022-0062.

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Abstract Recently, nanotechnology has been effectively used in the field of road pavement. Oxidation and aging of asphalt cause deterioration of road pavements and increase asphalt-related emissions. We propose an anti-aging strategy to interrupt the asphalt deterioration by using engineered clay/fumed silica nanocomposites. In this research, the morphological, chemical, thermal, mechanical, and rheological properties of nano-modified asphalt binders are meticulously analyzed in various conditions. The experiment results proved that this composite efficiently disrupts the chemical oxidation and decomposition in the mixture and reduces the aging rate. Remarkably, asphalt binder rheology experiments revealed that the addition of 0.2–0.3 wt% of nano-reinforced materials maximized their rheological resistance after short- and long-term aging. Moreover, nanoparticles improve the moisture resistance efficiency and in turn overcome the critical issue of moisture in low production temperature within the framework of warm mix asphalt technology. This cost-effective, facile, and scalable approach in warm mix asphalt mixtures can contribute to increased sustainability and lifespan of pavements and a reduction in greenhouse gas emissions.

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Nagwani, Amit Kumar. "FACTORS AFFECTING ANHYDROBIOSIS SURVIVAL IN EUTARDIGRADE PARAMACROBIOTUS EXPERIMENTALIS (MACROBIOTIDAE)". Innovation in Aging 6, Supplement_1 (1.11.2022): 814. http://dx.doi.org/10.1093/geroni/igac059.2932.

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Abstract Background Tardigrades, considered among animals the most resistant to complete loss of body water (desiccation) occurring during anhydrobiosis, are also interesting because of their place between the two primary invertebrate model organisms (Caenorhabditis elegans and Drosophila melanogaster). The effect of anhydrobiosis intensification on tardigrades’ age-specific survival has rarely been studied. The eutardigrade Paramacrobiotus experimenatlis is an excellent model of the study because their remarkable capacity for anhydrobiosis. This gives also possibility to apply the species in research on anhydrobiosis as an anti-aging strategy. Aim: Main goal of present study was to determine the effect of anhydrobiosis intensification, due to application of different duration and numbers of desiccation episodes, on the age-specific survival of Pam. experimenatlis. Methods Tardigrades were cultured under laboratory conditions, divided according to their age and sex, and subjected to several short and long desiccation episodes (3 and 30 days, respectively). The revival from desiccation was evaluated after 2-48h following rehydration. Results Individuals` age and anhydrobiosis intensity affected tardigrades` survival. Young adult animals survived the best, and the oldest ones the worst. The number of desiccation episodes affected animal survival stronger than desiccation duration. Conclusion The results are important for anhydrobiosis study as an-anti aging strategy. The work was supported by the research grants of the National Science Centre, Poland, NCN: 2016/21/B/NZ4/00131 and 2021/41/N/NZ3/01165.

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Null, Gary. "Lifestyle Modification Improves Physical and Mental Health in Elderly Participants: Observational Study in a Controlled Environment". Alternative, Complementary & Integrative Medicine 7, nr 4 (14.10.2021): 1–4. http://dx.doi.org/10.24966/acim-7562/100193.

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A 60-day observational study was conducted to evaluate how lifestyle modification principles relying upon a customized regimen of aerobic and muscle strength exercise, a plant-based diet and meditative stress reduction techniques may improve physical endurance and strength, mental health, and reverse normal aging associated with the average American lifestyle. All enrolled participants were generally in good health respective to their age. Several subjects had overlapping mild medical conditions. The results demonstrate that the intervention of a customized lifestyle modification regimen of regular daily exercise, a plant-based diet, and daily stress reduction practices, such as meditation and yoga, may provide a viable and beneficial preventative strategy as an anti-aging and wellness model to increase the physical and mental health of elderly men and women.

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Zou, Ling, Zhongbo Lou, Minghui Li, Honghua Xue, Yu Chen i Wengang Zhang. "Study on Prevention and Treatment Strategy of Asphalt Ultraviolet (UV) Aging Based on UV Climate Zoning in China". Applied Sciences 11, nr 14 (20.07.2021): 6665. http://dx.doi.org/10.3390/app11146665.

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The purpose of this paper, based on the amount of ultraviolet (UV) radiation in different areas of China, was to give the corresponding measures to prevent UV aging of asphalt. In this paper, based on the average annual amount of UV radiation in China in the past 30 years and the characteristics of UV aging of asphalt, the climatic zoning of UV radiation of asphalt in China was proposed. A variety of base asphalts and styrene–butadiene–styrene block copolymer (SBS) modified asphalts were selected to carry out a UV radiation test, and the relationship between UV radiation amount and viscosity, low-temperature performance, and the rheological properties of asphalt were studied. The equivalent aging indexes of asphalt during UV radiation were selected, the UV aging equation of asphalt was proposed, and the equivalent UV aging relationship among different UV climate zones was established. The prevention and control strategies of UV aging of asphalt among different zones were proposed, and the above theory was verified using a trial road. The main conclusions in the paper are presented: The climate zoning of asphalt UV radiation in China can be divided into three zones: zone I with an annual UV radiation less than or equal to 69.4 kW·h/m2 in the last 30 years; zone II with an annual UV radiation of 69.4~81.4 kW·h/m2 in the last 30 years; zone III with an annual UV radiation more than or equal to 81.4 kW·h/m2 in the last 30 years. The greater the amount of UV radiation, the greater the loss rate of penetration and ductility. For the same kind of asphalt, there is a relatively stable functional relationship between the loss rate and the amount of UV radiation. The results also show that UV radiation changes the proportion of viscous and elastic components in asphalt, showing that the proportion of viscous components decreases and the proportion of elastic components increases. The penetration loss rate and ductility loss rate of asphalt can be used as equivalent UV aging indexes of asphalt. Under the same outdoor UV irradiation time, for asphalt to achieve the same technical performance as zone I, the anti-UV ability of zone II needs to be improved by more than 5%, and that of zone III needs to be improved by more than 10%. Engineering practice has proved that the zoning established in this paper and the corresponding UV control measures are basically reasonable.

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Mittmann, Laura A., Florian Haring, Johanna B. Schaubächer, Roman Hennel, Bojan Smiljanov, Gabriele Zuchtriegel, Martin Canis i in. "Uncoupled biological and chronological aging of neutrophils in cancer promotes tumor progression". Journal for ImmunoTherapy of Cancer 9, nr 12 (grudzień 2021): e003495. http://dx.doi.org/10.1136/jitc-2021-003495.

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BackgroundBeyond their fundamental role in homeostasis and host defense, neutrophilic granulocytes (neutrophils) are increasingly recognized to contribute to the pathogenesis of malignant tumors. Recently, aging of mature neutrophils in the systemic circulation has been identified to be critical for these immune cells to properly unfold their homeostatic and anti-infectious functional properties. The role of neutrophil aging in cancer remains largely obscure.MethodsEmploying advanced in vivo microscopy techniques in different animal models of cancer as well as utilizing pulse-labeling and cell transfer approaches, various ex vivo/in vitro assays, and human data, we sought to define the functional relevance of neutrophil aging in cancer.ResultsHere, we show that signals released during early tumor growth accelerate biological aging of circulating neutrophils, hence uncoupling biological from chronological aging of these immune cells. This facilitates the accumulation of highly reactive neutrophils in malignant lesions and endows them with potent protumorigenic functions, thus promoting tumor progression. Counteracting uncoupled biological aging of circulating neutrophils by blocking the chemokine receptor CXCR2 effectively suppressed tumor growth.ConclusionsOur data uncover a self-sustaining mechanism of malignant neoplasms in fostering protumorigenic phenotypic and functional changes in circulating neutrophils. Interference with this aberrant process might therefore provide a novel, already pharmacologically targetable strategy for cancer immunotherapy.

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Seo, Dae Bang. "Ginseng Berry, a Promising Anti-Aging Strategy: Recent Opinions on the Biological Effects of a Traditional Korean Ingredient". Journal of Advanced Research in Biotechnology 1, nr 2 (2016): 1–8. http://dx.doi.org/10.15226/2475-4714/1/2/00101.

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Bai, Yunfei, Hongwen He, Jianwei Li, Shuangqi Li, Ya-xiong Wang i Qingqing Yang. "Battery anti-aging control for a plug-in hybrid electric vehicle with a hierarchical optimization energy management strategy". Journal of Cleaner Production 237 (listopad 2019): 117841. http://dx.doi.org/10.1016/j.jclepro.2019.117841.

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