Gotowa bibliografia na temat „Analyses haut débit”
Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych
Zobacz listy aktualnych artykułów, książek, rozpraw, streszczeń i innych źródeł naukowych na temat „Analyses haut débit”.
Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.
Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.
Artykuły w czasopismach na temat "Analyses haut débit"
Thieblemont, C., i L. Xerri. "Classifications moléculaires des lymphomes par analyses d’expression génique à haut débit". Oncologie 8, nr 4 (maj 2006): 314–21. http://dx.doi.org/10.1007/s10269-006-0389-z.
Pełny tekst źródłaMERSCH, Marjorie, Sarah-Anne DAVID, Anaïs VITORINO CARVALHO, Sylvain FOISSAC, Anne COLLIN, Frédérique PITEL i Vincent COUSTHAM. "Apports du séquençage haut-débit sur la connaissance de l'épigénome aviaire". INRA Productions Animales 31, nr 4 (23.01.2019): 325–36. http://dx.doi.org/10.20870/productions-animales.2018.31.4.2372.
Pełny tekst źródłaSallon, C., D. Soulet, R. Provost i Y. Tremblay. "Analyses automatisées à haut-débit de la morphométrie pulmonaire : une présentation de la puissance de l’outil". Revue des Maladies Respiratoires 33 (styczeń 2016): A182—A183. http://dx.doi.org/10.1016/j.rmr.2015.10.375.
Pełny tekst źródłaKoné, Lamine, Richard Razafferson, Bernard DéMoulin, Fabienne Moulin, Frédéric Gauthier i Ahmed Zeddam. "Analyses et mesures du rayonnement Électromagnétique engendré par des communications haut débit transmises sur des lignes d’énergie". Annales Des Télécommunications 60, nr 9-10 (październik 2005): 1169–96. http://dx.doi.org/10.1007/bf03219842.
Pełny tekst źródłaGuedj, Myriam, Marion Rosier, Patrick Calvas, Sophie Julia, Christelle Garnier, Anne Cambon thomsen i Maria Teresa Munoz Sastre. "Chapitre 8. Annoncer ou pas la découverte d’anomalies non sollicitées lors d’un test génétique à séquençage haut débit ?" Journal international de bioéthique et d'éthique des sciences Vol. 34, nr 2 (28.08.2023): 121–30. http://dx.doi.org/10.3917/jibes.342.0121.
Pełny tekst źródłaHajhouji, Youssef, Vincent Simonneaux, Simon Gascoin, Younes Fakir, Bastien Richard, Abdelghani Chehbouni i Abdelghani Boudhar. "Modélisation pluie-débit et analyse du régime d'un bassin versant semi-aride sous influence nivale. Cas du bassin versant du Rheraya (Haut Atlas, Maroc)". La Houille Blanche, nr 3 (czerwiec 2018): 49–62. http://dx.doi.org/10.1051/lhb/2018032.
Pełny tekst źródłaFRITZ, S., P. MICHOT, C. HOZE, C. GROHS, M. BOUSSAHA, D. BOICHARD i A. CAPITAN. "Anticiper l'émergence d'anomalies génétiques grâce aux données génomiques". INRA Productions Animales 29, nr 5 (9.01.2020): 339–50. http://dx.doi.org/10.20870/productions-animales.2016.29.5.3002.
Pełny tekst źródłaBernadou, G., I. Barillot, A. Régnault-Bougnoux, G. Calais, S. Chapet i A. Ruffier-Loubière. "Analyse comparative de la toxicité tardive de la curiethérapie de haut débit de dose et de celle de bas débit de dose du cancer de l’endomètre". Cancer/Radiothérapie 19, nr 6-7 (październik 2015): 685–86. http://dx.doi.org/10.1016/j.canrad.2015.07.121.
Pełny tekst źródłaLabruyere, M., A. Guilloteau, J. P. Quenot, J. M. Doise, G. Beltramo, C. Abdulmalak, N. Baudouin, P. Bonniaud i M. Georges. "Analyse de l’oxygénothérapie à haut débit dans une cohorte rétrospective multicentrique hospitalisés en réanimation pour insuffisance respiratoire aiguë hypoxémiante". Revue des Maladies Respiratoires 36 (styczeń 2019): A159. http://dx.doi.org/10.1016/j.rmr.2018.10.340.
Pełny tekst źródłaThomin, A., S. Bakkar, M. Trafi i E. Champeaux-Orange. "Analyse dosimétrique chez 50 patientes prises en charge par curiethérapie de haut débit de dose de la voûte vaginale". Cancer/Radiothérapie 22, nr 6-7 (październik 2018): 725. http://dx.doi.org/10.1016/j.canrad.2018.07.085.
Pełny tekst źródłaRozprawy doktorskie na temat "Analyses haut débit"
Yang, Bo. "Analyses bioinformatiques et classements consensus pour les données biologiques à haut débit". Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112250/document.
Pełny tekst źródłaIt is thought to be more and more important to solve biological questions using Bioinformatics approaches in the post-genomic era. This thesis focuses on two problems related to high troughput data: bioinformatics analysis at a large scale, and development of algorithms of consensus ranking. In molecular biology and genetics, RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined. The U2AF heterodimer has been well studied for its role in defining functional 3’ splice sites in pre-mRNA splicing, but multiple critical problems are still outstanding, including the functional impact of their cancer-associated mutations. Through genome-wide analysis of U2AF-RNA interactions, we report that U2AF has the capacity to define ~88% of functional 3’ splice sites in the human genome. Numerous U2AF binding events also occur in other genomic locations, and metagene and minigene analysis suggests that upstream intronic binding events interfere with the immediate downstream 3’ splice site associated with either the alternative exon to cause exon skipping or competing constitutive exon to induce inclusion of the alternative exon. We further build up a U2AF65 scoring scheme for predicting its target sites based on the high throughput sequencing data using a Maximum Entropy machine learning method, and the scores on the up and down regulated cases are consistent with our regulation model. These findings reveal the genomic function and regulatory mechanism of U2AF, which facilitates us understanding those associated diseases.Ranking biological data is a crucial need. Instead of developing new ranking methods, Cohen-Boulakia and her colleagues proposed to generate a consensus ranking to highlight the common points of a set of rankings while minimizing their disagreements to combat the noise and error for biological data. However, it is a NP-hard questioneven for only four rankings based on the Kendall-tau distance. In this thesis, we propose a new variant of pivot algorithms named as Consistent-Pivot. It uses a new strategy of pivot selection and other elements assignment, which performs better both on computation time and accuracy than previous pivot algorithms
Mersch, Marjorie. "Analyse de la méthylation de l'ADN par séquençage haut-débit chez la Poule". Thesis, Toulouse, INPT, 2018. http://www.theses.fr/2018INPT0107/document.
Pełny tekst źródłaAnticipating the impact of environmental changes (on climate and feed) is a crucial issue for livestock production systems, including poultry. The influence of the environment on phenotypes is partly mediated by epigenetic phenomena, including DNA methylation, which may be involved in the regulation of gene expression. These mechanisms do not affect the DNA sequence but can be inherited by mitosis or meiosis. The interactions between epigenomes and gene expression are increasingly being studied in animal models and in plants. However, the mechanisms of regulation of genome expression through DNA methylation are relatively unknown in birds. This thesis work is based on two experimental devices realized in chicken aiming to characterize the methylome by high-throughput sequencing. The methylation patterns across the genome, and their link with expression, were first established by whole-genome bisulfite sequencing (WGBS) in whole embryos, following a reduced representation bisulfite sequencing (RRBS) from hypothalamus of adults. To date, no specific chicken RRBS study has been published. These two analyses were carried out by developing an optimized bioinformatics pipeline, available for scientific community. Overall, the pattern of methylation in chicken is like those in mammals: CpG islands - dinucleotides CG-rich regions which are often poorly methylated, and which are found mainly in the promoter regions of the genome - are generally poorly methylated in promoters on WGBS and RRBS data. Embryo methylome analyses confirmed the absence of a dose-compensation phenomenon on sex chromosomes, or the presence of a hypermethylated region on the Z chromosome. The analyses of RRBS data revealed an overall hypermethylation of CGs across the genome, suggesting a methylation response to environmental stress. From the analysis of WGBS data, we found that the level of methylation in promoters was negatively correlated with the expression of the associated gene. For the first time, a specific allele methylation was also detected between chicken lines whose frequency is comparable to that observed in humans. On the RRBS data, preliminary results of the methylome response to environmental stresses showed the complex nature of this relationship. The use of a low-energy diet would led to greater mobilization of body fat, while individuals with heat stress had a lighter body weight. Integrating these data with phenotypic measurements would allow to link methylation and environment. Beyond the fundamental aspect of this thesis, the method developed in this work could be applied to livestock systems to breed animals better adapted to a changing environment, by improving production traits
Schoenauer, Sebag Alice. "Développement de méthodes pour les données de cribles temporels à haut contenu et haut débit : versatilité et analyses comparatives". Thesis, Paris, ENMP, 2015. http://www.theses.fr/2015ENMP0035/document.
Pełny tekst źródłaBiological screens test large sets of experimental conditions with respect to their specific biological effect on living systems. Technical and computational progresses have made it possible to perform such screens at a large scale - up to hundreds of thousands of experiments. Live cell imaging is an excellent tool to study in detail the consequences of chemical perturbation on a given biological process. However, the analysis of live cell screens demands the combination of robust computer vision methods, efficient statistical methods for the detection of significant effects and robust procedures for quality control. This thesis addresses these challenges by developing analytical methods for the analysis of High Throughput time-lapse microscopy screening data. The developed frameworks are applied to publicly available HCS data, demonstrating their applicability and the benefits of HCS data remining. The first multivariate workflow for the study of single cell motility in such large-scale data is detailed in Chapter 2. Chapter 3 presents this workflow application to previously published data, and the development of a new distance for drug target inference by in silico comparisons of parallel siRNA and drug screens. Finally, chapter 4 presents a complete methodological pipeline for performing HT time-lapse screens in Environmental Toxicology
Teissandier, Aurélie. "Analyses bioinformatiques de la régulation des éléments transposables chez les mammifères". Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS251/document.
Pełny tekst źródłaTransposable elements are DNA sequences that have the ability to move in the genome. They can modify the architecture and the regulation of the genome, and be implicated in different pathological, congenital or acquired disorders. The transposon analysis with sequencing data is the first choice method to understand their biology. My thesis work was dedicated to this question using real and simulated data. In a first research axis, using a cellular system to modulate DNA methylation levels, we revealed that different repressive chromatin modifications ensure the silencing of transposable elements when DNA methylation is lost. In a second axis, using a random mutagenesis strategy, we discovered a new DNA methyltransferase, specialized in the methylation of young transposons during spermatogenesis. However, the analysis of transposons in sequencing datasets is a bioinformatic challenge because of the repeated nature of transposable elements. Eventually, in a third axis, using a simulation strategy applied to the mouse and the human genomes, I systematically compared different alignment and quantification tools. I was able to draw recommendations for the analysis of transposons and to reveal the limits in detecting specific transposons families
Teissandier, Aurélie. "Analyses bioinformatiques de la régulation des éléments transposables chez les mammifères". Electronic Thesis or Diss., Sorbonne université, 2018. http://www.theses.fr/2018SORUS251.
Pełny tekst źródłaTransposable elements are DNA sequences that have the ability to move in the genome. They can modify the architecture and the regulation of the genome, and be implicated in different pathological, congenital or acquired disorders. The transposon analysis with sequencing data is the first choice method to understand their biology. My thesis work was dedicated to this question using real and simulated data. In a first research axis, using a cellular system to modulate DNA methylation levels, we revealed that different repressive chromatin modifications ensure the silencing of transposable elements when DNA methylation is lost. In a second axis, using a random mutagenesis strategy, we discovered a new DNA methyltransferase, specialized in the methylation of young transposons during spermatogenesis. However, the analysis of transposons in sequencing datasets is a bioinformatic challenge because of the repeated nature of transposable elements. Eventually, in a third axis, using a simulation strategy applied to the mouse and the human genomes, I systematically compared different alignment and quantification tools. I was able to draw recommendations for the analysis of transposons and to reveal the limits in detecting specific transposons families
François, Nicolas. "Analyse d'interactions moléculaires à haut débit". Paris 5, 2010. http://www.theses.fr/2010PA05S003.
Pełny tekst źródłaThis thesis tackles the locks held by emerging technologies for analyzing high throughput molecular interactions, allowing to acquire continuous measurements upon parallel interactions. Two technologies are promising: the target marking by fluorescence, which is a proven technique in biology; and the surface plasmon resonance (SPR), requiring no labeling of molecules. This thesis suggests an original automatic approach for image analysis of high throughput interactions, applicable to both fluorescence and SPR methods. From a mathematical model based upon common characteristics describing experimental studies, it combines 2D and 3D geodesic operators, classification and constraints of physical behavior. Coupled with the experimental protocol specific to each of the high throughput methods, involving calibrations and spatiotemporal filtering of noise, it ultimately provides a complete technology for the analysis of high throughput data. Assessed qualitatively and quantitatively on a data set, both synthetic and experimental, it confirms our expectations regarding the sensitivity of detection systems with high throughput, even at low concentrations of target. The characteristics of the interactions studied thus estimated were compared with those obtained by reference methods, or theoretical values. The results are in agreement, validating that the use of high throughput techniques for analyzing molecular interactions and the methodology developed for the exploitation of such data. This study thus opens new perspectives on the use of these technologies as well as part of research in biology, in a clinical setting to aid diagnosis or gene therapy
Aubert, Julie. "Analyse statistique de données biologiques à haut débit". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS048/document.
Pełny tekst źródłaThe technological progress of the last twenty years allowed the emergence of an high-throuput biology basing on large-scale data obtained in a automatic way. The statisticians have an important role to be played in the modelling and the analysis of these numerous, noisy, sometimes heterogeneous and collected at various scales. This role can be from several nature. The statistician can propose new concepts, or new methods inspired by questions asked by this biology. He can propose a fine modelling of the phenomena observed by means of these technologies. And when methods exist and require only an adaptation, the role of the statistician can be the one of an expert, who knows the methods, their limits and the advantages.In a first part, I introduce different methods developed with my co-authors for the analysis of high-throughput biological data, based on latent variables models. These models make it possible to explain a observed phenomenon using hidden or latent variables. The simplest latent variable model is the mixture model. The first two presented methods constitutes two examples: the first in a context of multiple tests and the second in the framework of the definition of a hybridization threshold for data derived from microarrays. I also present a model of coupled hidden Markov chains for the detection of variations in the number of copies in genomics taking into account the dependence between individuals, due for example to a genetic proximity. For this model we propose an approximate inference based on a variational approximation, the exact inference not being able to be considered as the number of individuals increases. We also define a latent-block model modeling an underlying structure per block of rows and columns adapted to count data from microbial ecology. Metabarcoding and metagenomic data correspond to the abundance of each microorganism in a microbial community within the environment (plant rhizosphere, human digestive tract, ocean, for example). These data have the particularity of presenting a dispersion stronger than expected under the most conventional models (we speak of over-dispersion). Biclustering is a way to study the interactions between the structure of microbial communities and the biological samples from which they are derived. We proposed to model this phenomenon using a Poisson-Gamma distribution and developed another variational approximation for this particular latent block model as well as a model selection criterion. The model's flexibility and performance are illustrated on three real datasets.A second part is devoted to work dedicated to the analysis of transcriptomic data derived from DNA microarrays and RNA sequencing. The first section is devoted to the normalization of data (detection and correction of technical biases) and presents two new methods that I proposed with my co-authors and a comparison of methods to which I contributed. The second section devoted to experimental design presents a method for analyzing so-called dye-switch design.In the last part, I present two examples of collaboration, derived respectively from an analysis of genes differentially expressed from microrrays data, and an analysis of translatome in sea urchins from RNA-sequencing data, how statistical skills are mobilized, and the added value that statistics bring to genomics projects
Pham, Nguyen Phuong. "Analyses génomiques comparatives de souches de Brevibacterium et étude de leurs interactions biotiques avec Hafnia alvei dans un fromage modèle". Electronic Thesis or Diss., Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLA035.
Pełny tekst źródłaThe objective of this study was to better understand the molecular mechanisms of microbial adaptation to the cheese habitat by functional genomic approaches using Brevibacterium as a model microorganism. This bacterium is widely used for the manufacturing of cheese but its growth on the cheese surface is sometimes difficult to control.Comparative genomic analysis of 23 Brevibacterium strains, including 12 strains isolated from cheeses, revealed differences in genetic determinants involved in the growth on the cheese surface. Some of them are correlated to strain phylogeny and others are the result of gene transfers, especially those involved in iron acquisition and bacteriocin biosynthesis. We identified genomic islands corresponding to transfers of genes involved in iron acquisition between cheese-associated Brevibacterium strains and cheese-associated strains belonging to other genera. We also detected a conjugative transposon encoding bacteriocin production, which is present in cheese-associated Brevibacterium strains as well as in a cheese-associated Corynebacterium strain.Functional study of biotic interactions between Brevibacterium and Hafnia alvei, another cheese-ripening bacterium, was performed in a model cheese developed in this study. By coupling microbial, biochemical and transcriptomic (RNA-seq) analyses, we revealed several interaction mechanisms between these bacteria. These concern, in particular, iron acquisition, proteolysis, lipolysis, sulfur metabolism and D-galactonate catabolism. Our findings suggest that in the mutualistic relationship between some Brevibacterium strains and H. alvei, the latter stimulates Brevibacterium growth by the secretion of siderophores, which can be used by Brevibacterium to capture iron more efficiently. In return, Brevibacterium secretes lipases and proteases, which degrade cheese caseins and triglycerides into energetic substrates that stimulate H. alvei growth. This type of interaction is interesting to consider in the formulation of ripening cultures because it results in a better ability of all partners to colonize the cheese, and thus to generate the desired technological properties
Mirat, Olivier. "Analyse haut-débit du comportement spontané d'un organisme modèle " simple "". Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-00881755.
Pełny tekst źródłaDionnet, Eugénie. "Exploration de l'hétérogénéité mutationnelle et de ses conséquences pathologiques dans les myopathies : analyses des mécanismes et développement d'outils thérapeutiques". Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM5046/document.
Pełny tekst źródłaNowadays, diagnosis and pathomechanisms of genetic disorders remain difficult to explore. There are actually more than 200 forms of myopathies, mostly genetics, even if the culprit gene is not always identified. However, even when the causative gene is known, it often remains diagnostic issues because of clinical and genetic heterogeneity and wide mutational spectrum. The lack of genetic information affects patients cares and impairs the development of new therapeutic tools. My thesis was conducted in order to extend these elements: I have shown that a new gene may be involved in facio-scapulo-humeral dystrophy; I have improved calpainopathie’s diagnosis by studying the impact of missense mutations on RNA splicing; I have also analyzed how proteins contributed to calcium entry in the cell. Finally, I contributed with a new therapeutic tools for dysferlinopathies
Książki na temat "Analyses haut débit"
Wang, Perry G. High-Throughput Analysis in the Pharmaceutical Industry (Critical Reviews in Combinatorial Chemistry). CRC, 2008.
Znajdź pełny tekst źródłaCzęści książek na temat "Analyses haut débit"
BANSARD, Elsa. "Covid-19 : La construction d’une pandémie comme « fait mondial total »". W Les épidémies au prisme des SHS, 21–34. Editions des archives contemporaines, 2022. http://dx.doi.org/10.17184/eac.5986.
Pełny tekst źródła