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Bailey, Jordan Michele Newland M. Christopher. "Mechanisms and performance measures in mastery-based incremental repeated acquisition behavioral and pharmacological analyses /". Auburn, Ala, 2009. http://hdl.handle.net/10415/1906.
Pełny tekst źródłaArmstrong, Victoria Diane. "Functional changes in neurons and glia following amphetamine-induced behavior sensitization". CSUSB ScholarWorks, 2003. https://scholarworks.lib.csusb.edu/etd-project/2168.
Pełny tekst źródłaBach, Mimi Vu. "The metabolism of amitriptyline and some analogs of amphetamine". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/nq22947.pdf.
Pełny tekst źródłaMead, Andy Neil. "Investigations into the role of ampa-receptor mediated transmission in conditioned, psychostimulant influenced behaviours". Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266445.
Pełny tekst źródłaFoster, Karen L. "Amphetamines and Western Australian detainees: A social profile". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2012. https://ro.ecu.edu.au/theses/487.
Pełny tekst źródłaApollonio, Luigino Giuseppe, i n/a. "INNOVATIONS IN SYSTEMATIC TOXICOLOGICAL ANALYSIS: AMPHETAMINETYPE SUBSTANCES AND DESIGNER ANALOGUES". University of Canberra. Applied Science, 2007. http://erl.canberra.edu.au./public/adt-AUC20081030.110007.
Pełny tekst źródłaReile, Phyllis A. Barker Lewis. "Effects of D-amphetamine on choice behavior under mixed concurrent schedules". Auburn, Ala., 2007. http://repo.lib.auburn.edu/Send%2002-04-08/REILE_PHYLLIS_48.pdf.
Pełny tekst źródłaTaylor, Anita Margaret. "The discriminative stimulus properties of the atypical antipsychotic clozapine". Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367204.
Pełny tekst źródłaFaulds, Karen Jade. "Detection of drugs of abuse by surface enhanced Raman scattering (SERS)". Thesis, University of Strathclyde, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288636.
Pełny tekst źródłaSlezak, Jonathan Michael. "Effects of variable training, signaled and unsignaled delays, and [delta]-amphetamine on delay-discounting functions obtained within session". Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5650.
Pełny tekst źródłaTitle from document title page. Document formatted into pages; contains vii, 52 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 44-48).
Hiroi, Noboru 1961. "A pharmacological and neuroanatomical investigation of the conditioned place preference produced by amphetamine /". Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74669.
Pełny tekst źródłaSlezak, Jonathan Michael. "Observing responses of chain-schedule stimuli and effects of [delta]-amphetamine and morphine". Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/10860.
Pełny tekst źródłaTitle from document title page. Document formatted into pages; contains vi, 71 p. : ill. Includes abstract. Includes bibliographical references (p. 64-71).
Geppert, Leanne Michele. "The Impact of Amphetamine and Cannabis Use on the Symptoms and Clinical Course of Early Psychosis". Thesis, Griffith University, 2008. http://hdl.handle.net/10072/365510.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Psychology
Griffith Health
Full Text
McAvoy, Yvonne. "The analysis of amphetamines and explosives by supercritical fluid chromatography : an evaluation". Thesis, Staffordshire University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287282.
Pełny tekst źródłaMoon, Nathan William. "The amphetamine years a study of the medical applications and extramedical consumption of psychostimulant drugs in the postwar united states, 1945-1980 /". Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31743.
Pełny tekst źródłaCommittee Chair: Tone, Andrea; Committee Member: Flamming, Douglas; Committee Member: Krige, John; Committee Member: Metzl, Jonathan; Committee Member: Usselman, Steven. Part of the SMARTech Electronic Thesis and Dissertation Collection.
Rahman, Abul Kaiser Mahmood Saiedur Boonyong Keiwkarnka. "Utilization of amphetamines among taxi motor cyclists and its correlates, in Nakornpathom province, Thailand /". Abstract, 1999. http://mulinet3.li.mahidol.ac.th/thesis/2542/42E-AbulKaiserMahmood.pdf.
Pełny tekst źródłaLieving, Lori M. "Effects of intertrial interval and d-amphetamine on temporally organized behavior of pigeons". Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2418.
Pełny tekst źródłaTitle from document title page. Document formatted into pages; contains vii, 54 p. : ill. Includes abstract. Includes bibliographical references (p. 51-54).
Tarver, John A. (John Arthur). "Chemical Ionization (CI) GC/MS Analysis of Underivatized Amphetamines Followed by Chiral Derivatization to Identify d and l-Isomers with Ion Trap Mass Spectrometry". Thesis, University of North Texas, 1991. https://digital.library.unt.edu/ark:/67531/metadc504248/.
Pełny tekst źródłaDalal, Suntanu. "Amphetamine drugs potentiate morphine analgesia in the formalin test". Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55488.
Pełny tekst źródłaPacker, Robert R. "The effect of d-amphetamine on habituation of schedule controlled operant behavior". Online access for everyone, 2008. http://www.dissertations.wsu.edu/Thesis/Summer2008/r_packer_070808.pdf.
Pełny tekst źródłaMcBride, Shawna M. "An examination of early life sodium manipulation and its role in amphetamine sensitization in adult offspring". Laramie, Wyo. : University of Wyoming, 2008. http://proquest.umi.com/pqdweb?did=1799961721&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.
Pełny tekst źródłaThomas, Lee Davis. "Effects of d-amphetamine on signaled and unsignaled delays to reinforcement". View electronic thesis (PDF), 2009. http://dl.uncw.edu/etd/2009-1/thomasl/leethomas.pdf.
Pełny tekst źródłaShoobridge, Jodie. "An assessment of knowledge and risk behaviour among users of psychostimulants (amphetamines, ecstasy and LSD) /". Title page, table of contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09ARPS/09arpss559.pdf.
Pełny tekst źródłaGore, Sayali Gore. "Behavioral characterization of substituted amphetamines and their synthetic cathinone analogues in the rusty crayfish (Orconectes rusticus)". Bowling Green State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1510511175410233.
Pełny tekst źródłaSilber, Yvonne Beata. "The acute side effects of d-amphetamine and methamphetamine on simulated driving performance, cognitive functioning, brain activity, and the standardised field sobriety tests". Australasian Digital Theses Program, 2006. http://adt.lib.swin.edu.au/public/adt-VSWT20070319.105603/index.html.
Pełny tekst źródłaTypescript. [Submitted for the degree of] Doctor of Philosophy, Swinburne University of Technology - 2006. Includes bibliographical references (p. 253-290).
Turnquest, Britt E. "Rapid Inline Derivatization of Primary and Secondary Amine Containing Drugs by Capillary Electrophoresis with Laser-Induced Fluorescence". FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/998.
Pełny tekst źródłaHiggins, William J. "Do delay signals modulate the effect of d-amphetamine on "self-control" choice?" View electronic thesis (PDF), 2009. http://dl.uncw.edu/etd/2009-1/r3/higginsw/williamhiggins.pdf.
Pełny tekst źródłaCOSTA, GIULIA. "Vulnerability to cognitive, neurotoxic and neuroinflammatory effects of toxins that induce Parkinson's disease after administration of amphetamine-related drugs in mice". Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266444.
Pełny tekst źródłaNolte, Susan. "The effects of amphetamines on people with schizophrenia and healthy people : a systematic review and meta-analysis". Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396574.
Pełny tekst źródłaHand, Timothy Henry. "Effects of morphine on intracranial self-stimulation : the involvement of associative factors and the role of ventral tegmental dopamine neurons". Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=72033.
Pełny tekst źródłaBazzarella, Rafael Barcellos. "Desenvolvimento de metodologia analítica para a investigação de anfetaminas em amostras de saliva, empregando cromatografia em fase gasosa acoplada a espectrometria de massas". Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-24052010-204423/.
Pełny tekst źródłaThe use of stimulants by professional drivers is known as an increasing risk of accidents on the roads. The type of work itself induces the drivers to look out for something that provides better state of alertness and reduced sleep. Based on this important correlation between the occupation and use of stimulants, an analytical methodology was proposed for the determination of amphetamine, methamphetamine, and their methylenedioxy derivatives 3,4 methylenedioxyamphetamine, 3-4 methylenedioxymethamphetamine and 3,4 methylenedioxyethylamphetamine on oral fluid samples using solvent extraction and gas chromatography coupled with mass spectrum for detection and quantification of these analytes. The developed methodology used 1 mL of oral fluid, liquid-liquid extraction, heptafluorobutyric anhydride and gas chromatography-mass spectrometry for the detection and quantification. The methodology was validated and showed good linearity within the limits of 10 ng/mL and 400 ng/mL of oral fluid. The limits of detection were between 2.5 ng/mL and 7.5 ng/mL, while the limits of quantification were 10 ng/mL for all analytes. The accuracy showed values between 93.8% e 108.3%, the intra-assay precision between 4.05% e 9.34% and the inter-assay precision between 5.28% e 9.90%. The validated methodology was tested in oral fluid samples collected from truck drivers near the city of Roseira São Paulo during an event of health assistance fomented by SEST/SENAT in partnership with Federal Police. It was collected 40 saliva samples and two of them presented positive result for amphetamine.
Choi, Fiona Yeuk-Lun. "The effects of (RS)-MCPG on amphetamine-induced sensitization in neonatal rats". CSUSB ScholarWorks, 2006. https://scholarworks.lib.csusb.edu/etd-project/3181.
Pełny tekst źródłaRostberg, James I. "Common chemicals as precursors of improvised explosive devices : the challenges of controlling domestic terrorism". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2005. http://library.nps.navy.mil/uhtbin/hyperion/05Sep%5FRostberg.pdf.
Pełny tekst źródłaThesis Advisor(s): Maria Rasmussen, Robert Simeral. Includes bibliographical references (p. 73-74). Also available online.
Doremus-Fitzwater, Tamara L. "Incentive motivational processes in adolescent and adult rats effects of amphetamine sensitization on cue-induced craving for natural rewards /". Diss., Online access via UMI:, 2008.
Znajdź pełny tekst źródłaKarper, Patrick Eugene. "Role of the Dopamine D₁-like receptor in amphetamine-induced behavioral sensitization: A study using Dopamine D₁A-receptor deficient mice". CSUSB ScholarWorks, 2000. https://scholarworks.lib.csusb.edu/etd-project/1682.
Pełny tekst źródłaBriggs, Wendy Sue, i Kelly-Jo Chastain-Carlton. "Alcohol and amphetamine dependencies convoluted with anorexia and bulimia nervosa". CSUSB ScholarWorks, 1997. https://scholarworks.lib.csusb.edu/etd-project/1420.
Pełny tekst źródłaROSA, KENIG ARIANE. "Antagonistes dopaminergiques : effets compares sur la reponse comportementale et striatale induite par les amphetamines chez le rat eveille et libre de ses mouvements". Amiens, 1994. http://www.theses.fr/1994AMIEM059.
Pełny tekst źródłaCOLTURATO, MARIA T. "Otimização das condições de marcação do cloridrato de N-isopropil-p-iodoanfetamina (IMP) com radioiodo. Estudos de distribuição biológica". reponame:Repositório Institucional do IPEN, 2000. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9295.
Pełny tekst źródłaMade available in DSpace on 2014-10-09T14:03:33Z (GMT). No. of bitstreams: 1 11316.pdf: 4559706 bytes, checksum: 49490bf32ac2f606f4a79e8d49abe990 (MD5)
Dissertacao (Mestrado)
IPEN/D
Intituto de Pesquisas Energeticas e Nucleares, IPEN/CNEN-SP
Pantaleão, Lorena do Nascimento. "Análise toxicológica de anfetaminas e benzodiazepínicos em amostras de cabelo por cromatografia gasosa acoplada à espectrometria de massas". Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-02042014-104017/.
Pełny tekst źródłaAmphetamines are a class of compounds with chemical structures similar to phenylethylamines that present stimulant activity in the central nervous system. Anorectic drugs such as fenproporex and diethylpropion and some illicit drugs as methamphetamine (ice, speed) and metilenodioximetamphetamine (MDMA, ecstasy) are also included in this class. These substances have a high abuse potential, and they can be used by various social groups, for example, professional drivers (who call them \"rebites\"), young students (using ecstasy in \"rave\" parties) and people who abuses anorectics to weight control. Interestingly, there is also a possibility of some people using anorectics and benzodiazepines in association. Although the commercialization of amphetamine derivatives has been recently banned in Brazil (2011), it is known that some people still use anorectic drugs and benzodiazepines to control insomnia induced by amphetamines. Another case of concomitant use would be professional drivers, who use \"rebites\", which also try to control their sleep cycles using benzodiazepines. Because of this situation, it would be interesting to monitoring the use of these drugs by toxicological analysis. The conventional toxicological analyses (performed in most cases in blood and urine) generally provide small window detection. In this case, intermittent drug use may not be detected. When long term information about drug use is needed, the most efficient matrix to carry out the analysis is hair. In this project, analytical methods were developed for the determination of amphetamines (amphetamine, methamphetamine, MDMA, MDA and fenproporex) and benzodiazepines (diazepam, nordiazepam, chlordiazepoxide, oxazepam, clonazepam and temazepam) in hair samples. Liquid-phase microextraction (LPME) and solid phase extraction (SPE) were used as sample preparation techniques in these methods. Analites were identified by gas chromatography/mass spectrometry (GC-MS). After the development, optimization and validation, the methods were applied in hair samples collected from patients of a drug rehabilitation clinic. The results obtained with the application of the developed methods showed their efficacy for the intended purpose.
September, Roxanne. "A case study examining the experiences of a methamphetamine addict and its impact on the family relationships". Thesis, Online Access, 2008. http://etd.uwc.ac.za/usrfiles/modules/etd/docs/etd_gen8Srv25Nme4_6941_1262646226.pdf.
Pełny tekst źródłaOdenwald, Michael. "The use of the stimulant khat, war-related trauma and psychosis in Somalia how changed use patterns of a traditional drug are related to psychiatric problems in a country in the transition from war to peace /". [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-23510.
Pełny tekst źródłaLucas, Natasha. "The Analysis of Recreational Drugs in Biological Specimens Using Liquid Chromatography Mass Spectrometry". The University of Waikato, 2008. http://hdl.handle.net/10289/2471.
Pełny tekst źródłaClark, Jeremy James. "Salt appetite and psychostimulants : interaction between reward systems/". Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/9071.
Pełny tekst źródłaBombana, Henrique Silva. "Análise de anfetamina, cocaína e tetrahidrocanabinol em fluido oral de motoristas de caminhão que trafegam em rodovias do estado de São Paulo". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-06032017-164651/.
Pełny tekst źródłaIn Brazil, in 2014 it caused more than 44 thousand deaths. In Brazil is already described in the literature the use of psychoactive substances by truck drivers to maintain their extensive work schedule and stay awake for several hours. Important highways cross through Sao Paulo to other regions from Brazil and to countries from Latin America. This study aims to demonstrate the prevalence of illicit drug use by truck drivers on the State of Sao Paulo through toxicological analyses on oral fluid. Truck drivers were randomly stopped by police officers on federal roads during morning hours. Oral fluid samples were collected using the Quantisal(TM) device. In addition, a questionnaire concerning sociodemographic characteristics and health information was administered. Oral fluid samples were screened for amphetamine, cocaine, and tetrahydrocannabinol (?9-THC) by ELISA. The samples were confirmed by GC-MS, using validated methods for the substances of interest. During the development of this study we had the opportunity to send the positive samples to the Norwegian Institute of Public Health for confirmation using UPLC-MS/MS. Besides cocaine, amphetamine and delta9-THC the samples were tested for others 29 samples, including illicit drugs and psychoactive medicines. 762 drivers agreed to participate. Of the total samples 5.2% (n = 40) tested positive for drugs. Cocaine was the most found drug (n = 16), followed by amphetamine (n = 11) and delta9-THC (n = 4). Furthermore, three samples tested positive for cocaine and delta9-THC and one sample for cocaine and amphetamine. The confirmation using UPLC-MS/MS pointed another two substances that were not tested previously, meprobamate and alprazolam (two samples tested positive for amphetamine and meprobamate, one for amphetamine and alprazolam and another one for cocaine and meprobamate). Drivers presenting positive samples were younger, with less education, less experienced, had a longer work schedule and drove longer distances. This fact shows that, undoubtedly, there is need for more national studies regarding the use of psychoactive substances, illicit and medicines, for a better understand by the scientific community and those responsible for implementation of public policies aiming the control of the use of these substances, in order to, one day, we were able to indeed reduce traffic accidents mortality in our country
Duart, Castells Leticia. "Neurochemical and psychopharmacological study of MDPV, a cocaine-like psychostimulant. Characterization of structurally-related second-generation synthetic cathinones". Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/668800.
Pełny tekst źródłaLas drogas de abuso representan un problema global no solo a nivel de salud, sino también a nivel social y económico. Recientemente, una ola de nuevas sustancias psicoactivas ha modificado por completo el mercado de las drogas ilegales, por lo que millones de personas en todo el mundo están consumiendo cientos de nuevas sustancias, la mayoría de las cuales apenas se conocen. Entre ellas, ha surgido una nueva familia de derivados anfetamínicos, denominados catinonas sintéticas, siendo la 3,4-mentilendioxipirovalerona (MDPV) una de las catinonas sintéticas de primera generación más populares. La MDPV comparte mecanismo de acción con la cocaína y su consumo está a menudo relacionado con intoxicaciones agudas graves, drogodependencia e incluso muertes. En este contexto, esta tesis doctoral tiene como objetivo contribuir al conocimiento científico proporcionando nueva información sobre la MDPV, más concretamente, sobre los cambios neuroadaptativos subyacentes al abuso de ésta, sus propiedades adictivas, sus efectos conductuales, así como sobre su relación con la cocaína, el psicoestimulante más consumido en todo el mundo. En resumen, la exposición repetida a MDPV induce anormalidades conductuales tales como comportamientos relacionados con ansiedad y una mayor toma de riesgos, agresividad y sensibilización locomotora. Además, ejerce potentes efectos gratificantes. Cabe destacar que se ha evidenciado una sensibilización locomotora y una recaída cruzada entre cocaína y MDPV. No obstante, a pesar de las grandes similitudes entre ambos psicoestimulantes, las respuestas intracelulares que desencadenan en las áreas cerebrales que forman parte del circuito de recompensa difieren notablemente. Mientras que la primera parte de la presente tesis doctoral se ha centrado en el estudio de la MDPV, la segunda parte se ha dedicado a caracterizar la farmacología in vitro, así como las propiedades psicoestimulantes y gratificantes de nuevas catinonas sintéticas de segunda generación estructuralmente relacionadas con la MDPV. En resumen, todos los compuestos testados demostraron ser potentes inhibidores de la recaptación de dopamina y noradrenalina, y su potencia para inhibir dichos transportadores varía según su grupo amino-terminal. Además, todas ellas provocaron potentes efectos psicoestimulantes y gratificantes en el ratón, hechos que demuestran su potencial de abuso.
Les drogues d’abús representen un problema global no només a nivell de salut, sinó també a nivell social i econòmic. Recentment, una onada de noves substàncies psicoactives ha modificat completament el mercat de les drogues il·legals, així doncs, milions de persones en tot el món estan consumint centenars de noves substàncies, la majoria de les quals gairebé no es coneixen. Entre elles, ha sorgit una nova família de derivats amfetamínics, anomenats catinones sintètiques, essent la 3,4-metilendioxipirovalerona (MDPV) una de les catinones sintètiques de primera generació més populars. La MDPV comparteix mecanisme d’acció amb la cocaïna i el seu consum està sovint relacionat amb intoxicacions agudes greus, drogodependència i fins i tot, morts. En aquest context, aquesta tesi doctoral té com a objectiu contribuir al coneixement científic proporcionant nova informació sobre la MDPV, més concretament, sobre els canvis neuroadaptatius subjacents a l’abús d’aquesta, les seves propietats addictives, els seus efectes conductuals, així com sobre la seva relació amb la cocaïna, el psicoestimulant més consumit arreu del món. En resum, l’exposició repetida a MDPV indueix anormalitats conductuals com ara comportaments relacionats amb ansietat i una major presa de riscs, agressivitat i sensibilització locomotora. A més a més, exerceix potents efectes gratificants. Cal destacar que s’ha evidenciat una sensibilització locomotora i una recaiguda creuada entre cocaïna i MDPV. No obstant això, malgrat les grans similituds entre ambdós psicoestimulants, les respostes intracel·lulars que desencadenen en àrees cerebrals que formen part del circuit de recompensa difereixen notablement. Mentre que la primera part de la present tesi doctoral s’ha centrat en l’estudi de la MDPV, la segona part s’ha dedicat a caracteritzar la farmacologia in vitro, així com les propietats psicoestimulants i gratificants de noves catinones sintètiques de segona generació estructuralment relacionades amb la MDPV. En resum, tots els compostos assajats van demostrar ser potents inhibidors de la recaptació de dopamina i noradrenalina, i la seva potència per inhibir aquests transportadors varia en funció del seu grup amino-terminal. A més, totes elles van provocar potents efectes psicoestimulants i gratificants en el ratolí, fets que posen de manifest el seu potencial d’abús.
Takitane, Juliana. "Verificação do uso de anfetaminas (\"rebite\") por motoristas profissionais através da análise toxicológica em urina". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-24102014-121944/.
Pełny tekst źródłaIn Brazil, studies indicate an increase of approximately 30% in the number of traffic accidents on federal highways, from 2008 to 2010 and, in 2010, cargo vehicles, specifically, were involved in 88,963 accidents. In fact, many professional drivers have tight deadlines to be met and, therefore, are forced to drive for long periods of time and/or without rest stops. In order to achieve this goal, some drivers end up resorting to the use of amphetamines, CNS stimulants, popularly known in Brazil as \"rebite\". Toxicological analyses used to verify the use of drugs by truck drivers in epidemiological studies are based on immunoassays screening tests and positive results are confirmed by mass spectrometry techniques. The commercially available screening tests detect the presence of amphetamine, which can be derived from the biotransformation of some drugs. However, truck drivers also report the use of anorectic Dualid® S, Hipofagin® S and Inibex® S, whose active compound is diethylpropion, which metabolizes directly to phenylpropanolamine. Therefore it is not detected by conventional screening tests, which can generate false-negative results and underestimate the number of positive cases. Thus, the aim of this study was the development and validation of a method for the detection of amphetamine, diethylpropion and fenproporex by high performance liquid chromatography (HPLC-DAD) and the subsequent application of this method in urine samples collected from truck drivers. The liquid-liquid extraction of urine (2.0 mL) was carried out with diethyl ether (4.0 mL) and the validation was performed according to United Nations Office on Drugs and Crime guidelines. The limits of detection and quantification were 120 and 150 ng/mL, respectively. The method was precise, with coefficients of variation less than 15% and the recovery for the three analytes was greater than 50%. The linearity covered the range of 150 ng/mL to 1000 ng/ml (r2 > 0.99) and for diethylpropion and amphetamine it was applied the weighting factor 1/y due to heteroscedasticity. Among the analyzed samples (n=385), nine were positive for amphetamine and one tested positive for femproporex and amphetamine. Sociodemographic profile of the interviewees was obtained through the application of questionnaires. The developed method proved to be accurate and sensitive, and thus can be used in epidemiological studies and in workplace drug testing
Sharp, Jennifer Ann. "Limiting loss: a grounded theory of mothers who use illicit drugs". Thesis, Curtin University, 2010. http://hdl.handle.net/20.500.11937/513.
Pełny tekst źródłaLópez, Arnau Raúl. "Nuevas drogas psicoestimulantes. Estudio farmacológico y neurotoxicológico de la metilona". Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/284625.
Pełny tekst źródłaA decrease in the illegal availability of chemical compounds used for the synthesis of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) or Ecstasy, coupled with a more than 50% decrease in the purity of ecstasy or cocaine (Measham et al., 2010; Winstock et al., 2011), has resulted in the appearance on the black market of a new generation of designer drugs known as ‘cathinones’ or ‘beta-keto amphetamines’ (the latter name deriving from the characteristic presence of a ketone in the side chain). These derivatives include a wide range of substances such as butylone, ethylone, methylone and mephedrone (4-methylmethcathinone). Butylone, mephedrone and methylone caused hyperlocomotion, which was prevented with ketanserin or haloperidol. Methylone was the most potent compound inhibiting both [3H]5-HT and [3H]dopamine uptake. Mephedrone was found to be the cathinone derivative with highest affinity for vesicular monoamine transporter-2 causing the inhibition of dopamine uptake. The affinity of cathinones for 5-HT2A receptors was similar to that of MDMA. Oral administration of methylone induced a dose-dependent increase in locomotor activity in rats. The plasma concentrations after i.v. administration were described by a two-compartment model. For oral administration, peak methylone concentrations were achieved between 0.5 and 1 h and fitted to a flip-flop model. Absolute bioavailability was about 80%. We have identified four Phase I metabolites after oral administration. The major metabolic routes are N-demethylation, aliphatic hydroxylation and O-methylation of a demethylenate intermediate. Repeated methylone administration induced hyperthermia and a significant loss in rodent body weight. Methylone induced transient dopaminergic (frontal cortex) and serotoninergic (hippocampus) impairment in mice. We found evidence of astrogliosis in the CA1 and the dentate gyrus of the hippocampus. The animals also showed an increase in immobility time in the forced swim test, pointing to a depressive-like behavior. We also determined a serotonergic impairment in methylone-treated rats, especially in the frontal cortex, where it was accompanied by astrogliosis. Some serotonergic alterations were also present in the hippocampus and striatum. No significant neurotoxic effect on the dopaminergic system was identified. Methylone-treated rats only displayed impairments in the probe trial of the Morris water maze, which concerns reference memory, while the spatial learning process seemed to be preserved.
Jonson, Sten. "Identification and forensic classification of amphetamine /". Linköping : Univ, 2000. http://www.bibl.liu.se/liupubl/disp/disp2000/tek641s.htm.
Pełny tekst źródłaMartin, Eleanor. "Attributional beliefs of recreational amphetamine users". Thesis, University of East London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.532425.
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