Rozprawy doktorskie na temat „Alzheimer's disease”
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Russell, Teresa. "Alzheimer's disease : expressed concern for problem behaviors /". free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p1390668.
Pełny tekst źródłaNavaratnam, Dasakumar Selveraj. "Cholinesterases in Alzheimer's disease". Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306734.
Pełny tekst źródłaNewman, Tracey Anne. "Ageing and Alzheimer's disease". Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246220.
Pełny tekst źródłaMontacute, Rebecca. "Infection in Alzheimer's disease". Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/infection-in-alzheimers-disease(a69fbf77-1455-4a78-a700-54815cad926d).html.
Pełny tekst źródłaZubair, Mohammed. "Metabolomics in Alzheimer's disease". Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/metabolomics-in-alzheimers-disease(0872757b-d25a-4c43-bd52-915d4cad21c6).html.
Pełny tekst źródłaShie, Feng-Shiun. "Cholesterol and Alzheimer's disease /". Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/6604.
Pełny tekst źródła梁欣珮 i Yan-pui Irene Leung. "Potential impact of alzheimer's disease on retina". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42905059.
Pełny tekst źródłaHynd, Matthew. "Excitotoxic neurodegeneration in Alzheimer's disease /". [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18145.pdf.
Pełny tekst źródłaBlom, Elin. "Genetic Studies of Alzheimer's Disease". Doctoral thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9397.
Pełny tekst źródłaBakerink, Ronda Ann. "Semantic memory in Alzheimer's Disease". Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27795.
Pełny tekst źródłaMedicine, Faculty of
Audiology and Speech Sciences, School of
Graduate
Williams, Abigail J. "Cystatin C and Alzheimer's disease". Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/8547/.
Pełny tekst źródłaBeffert, Uwe. "Apolipoprotein E in Alzheimer's disease". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0021/NQ55300.pdf.
Pełny tekst źródłaBothmer, John. "Phosphoinositides, aging and Alzheimer's disease". Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1992. http://arno.unimaas.nl/show.cgi?fid=6504.
Pełny tekst źródłaHowell, Walter Mathias. "SNP technology and Alzheimer's disease /". Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-473-9/.
Pełny tekst źródłaNaidj, Sonia. "Visuospatial dysfunction in Alzheimer's disease". Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23924.
Pełny tekst źródłaXu, Chun. "Morphological subtypes of Alzheimer's disease". Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61223.
Pełny tekst źródłaThe study, based on (a) brain autopsy, (b) standardized histopathology, and (c) quantitative morphometry, shows heterogeneity in pathophenotypes of AD. Four morphological subgroups have been presently recognizes, by their characteristic histological abnormalities, and the densities, the distribution, and progression patterns of their lesions. The heterogeneity in pathophenotypes indicates that AD is not a disease with a single cause, but rather a syndrome with multiple elements involved in etiology and pathogenesis. These lead to different pathological features, and correspondingly, similar, but distinguishable clinical expressions.
Spillantini, Maria Grazia. "Molecular neuropathology of Alzheimer's disease". Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282037.
Pełny tekst źródłaBourne, Nathan T. "Molecular mechanisms of Alzheimer's disease". Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521906.
Pełny tekst źródłaSmith, M. A. "Protein structures and Alzheimer's disease". Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.291081.
Pełny tekst źródłaTreanor, James J. S. "Neurotrophic factors and Alzheimer's disease". Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385730.
Pełny tekst źródłaBucks, Romola Starr. "Intrusion errors in Alzheimer's disease". Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285578.
Pełny tekst źródłaFox, Sarah. "Oscillations memory and Alzheimer's disease". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/oscillations-memory-and-alzheimers-disease(bbacb2f0-74f3-4071-b02f-19c0c5570227).html.
Pełny tekst źródłaBenjamin, Maxwell J. "Autobiographical memory in Alzheimer's Disease". Thesis, Canterbury Christ Church University, 2013. http://create.canterbury.ac.uk/12348/.
Pełny tekst źródłaDavidson, Madeiene E. "Alzheimer's Disease: The Triple Threat". Scholarship @ Claremont, 2016. http://scholarship.claremont.edu/cmc_theses/1287.
Pełny tekst źródłaKim, Sohee. "Computational modeling in Alzheimer's disease". The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1267541374.
Pełny tekst źródłaHuseby, Carol. "Molecular Neuropathology in Alzheimer's Disease". The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1543314678552794.
Pełny tekst źródłaMorshed, Nader Francis. "Phosphoproteomics analysis of Alzheimer's disease". Thesis, Massachusetts Institute of Technology, 2021. https://hdl.handle.net/1721.1/130816.
Pełny tekst źródłaCataloged from the official PDF version of thesis.
Includes bibliographical references (pages [137]-[153]).
Alzheimer's disease (AD) is a form of dementia characterized by the appearance of amyloid-[beta] plaques, neurofibrillary tangles, and inflammation in brain regions involved in memory. Despite numerous clinical trials, a limited understanding of disease pathogenesis has prevented the development of effective therapies. Several lines of genetic and biomolecular evidence indicate that AD progression involves cellular signaling through neuronal and glial protein phosphorylation networks. In order to understand which phosphorylation networks are dysregulated, I use mass spectrometry to characterize the phosphoproteome of post-mortem brain tissue from AD patients and multiple mouse models of AD. Using computational analysis, I identified several signaling pathways that are dysregulated before neurodegeneration occurs. Many of these signaling factors were expressed primarily in non-neuronal cell types, including microglia, astrocytes, and oligodendrocytes.
My results highlight potential therapeutic targets in the signaling responses of glial cells and are split into two parts. In the first part of this thesis, I have quantified the phosphoproteome of the CK-p25, 5XFAD, and Tau P301S mouse models of neurodegeneration. I identified a shared response involving Siglec-F which was upregulated on a subset of reactive microglia. The human paralog Siglec-8 was also found to be upregulated on microglia in AD. Siglec-F and Siglec-8 were upregulated following microglial activation with interferon gamma (IFN[gamma]) in BV-2 cell line and human stem-cell derived microglia models. Siglec-F overexpression activates an endocytic and pyroptotic inflammatory response in BV-2 cells, dependent on its sialic acid substrates and immunoreceptor tyrosine-based inhibition motif (ITIM) phosphorylation sites. Related human Siglecs induced a similar response in BV-2 cells.
Collectively, my results point to an important role for mouse Siglec-F and human Siglec-8 in regulating microglial activation during neurodegeneration. In the second part of this thesis, I performed a combined analysis of the tyrosine, serine, and threonine phosphoproteome, and proteome of temporal cortex tissue from AD patients and aged matched controls. I identified several co-correlated peptide modules that were associated with varying levels of Tau, oligodendrocyte, astrocyte, microglia, and neuronal pathologies in different patients. I observed phosphorylation sites on known Tau-kinases and other novel signaling factors that were correlated these peptide modules. Finally, I used a data-driven statistical modeling approach to identify individual peptides and co-correlated signaling networks that were predictive of AD pathologies. Together, these results build a map of pathology-associated phosphorylation signaling events occurring in AD.
by Nader Francis Morshed.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Biological Engineering
Townsend, Kirk Phillip. "Microglia activation in Alzheimer's disease". [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000489.
Pełny tekst źródłaMorris, Eva Marie. "Semantic Memory in Alzheimer's Disease". W&M ScholarWorks, 1999. https://scholarworks.wm.edu/etd/1539626235.
Pełny tekst źródłaWang, Juelu. "Selective neurodegeneration in Alzheimer's disease and Parkinson's disease". Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63267.
Pełny tekst źródłaMedicine, Faculty of
Graduate
Rickle, Annika. "PTEN and Akt signalling in Alzheimer's disease /". Stockholm : Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-514-3/.
Pełny tekst źródłaHolt, Jim. "Alzheimer’s Disease". Digital Commons @ East Tennessee State University, 2009. https://dc.etsu.edu/etsu-works/6482.
Pełny tekst źródłaVasseur, Janis S. "The geographical implications of Alzheimer's disease : an examination of the impact that Alzheimer's disease hs on family caregivers in Connecticut /". Abstract Full Text (PDF), 2008. http://eprints.ccsu.edu/archive/00000509/02/1965FT.pdf.
Pełny tekst źródłaThesis advisor: Cynthia Pope. "... in partial fulfillment of the requirements for the degree of Master of Science in Geography." Includes bibliographical references (leaves 85-90). Also available via the World Wide Web.
Ridha, Basil Hassan. "MRI in Alzheimer's disease: beyond exclusion". Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486616.
Pełny tekst źródłaZhang, Xiaojie. "Roles of TMP21 in Alzheimer's disease". Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/50490.
Pełny tekst źródłaMedicine, Faculty of
Graduate
Scott, Louise A. "Analysis of apraxia in Alzheimer's disease". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ53514.pdf.
Pełny tekst źródłaMacQuarrie, Colleen. "Experiences in early stage Alzheimer's disease". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ61663.pdf.
Pełny tekst źródłaVestling, Monika. "Alzheimer's disease mutations and cellular signalling /". Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4993-X.
Pełny tekst źródłaTepper, Sherri. "A biopsychosocial model of Alzheimer's disease /". Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59861.
Pełny tekst źródłaBeyer, N. B. "Metal ion transport and alzheimer's disease". Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517106.
Pełny tekst źródłavan, Helmond Zoe Kerrstin. "Oligomeric A(beta) in Alzheimer's disease". Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.521086.
Pełny tekst źródłaBarker, Rachel Mary. "The plasminogen system in alzheimer's disease". Thesis, University of Bristol, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529891.
Pełny tekst źródłaBrooks, W. M. "Profiling gene expression in Alzheimer's disease". Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596943.
Pełny tekst źródłaHardy, Rachel Margaret. "Coping and awareness in Alzheimer's disease". Thesis, University of Birmingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420420.
Pełny tekst źródłaGolden, H. L. "Auditory scene analysis in Alzheimer's disease". Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1474234/.
Pełny tekst źródłaPatel, Tulsi. "Investigating genetic variation in Alzheimer's disease". Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52447/.
Pełny tekst źródłaRowan, Mark Stephen. "Information-selectivity of Alzheimer's disease progression". Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4328/.
Pełny tekst źródłaJarrett, Joseph Timothy. "Amyloid fibril formation in Alzheimer's disease". Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/70666.
Pełny tekst źródłaOrr, Miranda, i Salvatore Oddo. "Autophagic/lysosomal dysfunction in Alzheimer's disease". BioMed Central, 2013. http://hdl.handle.net/10150/610220.
Pełny tekst źródłaPatel, Yogen. "DNA methylation analysis of Alzheimer's disease". Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/dna-methylation-analysis-of-alzheimers-disease(f66ad885-3fdd-4c12-a73a-921cc31ccac2).html.
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