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Artykuły w czasopismach na temat „Allelomorphism”

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Sprawdź 17 najlepszych artykułów w czasopismach naukowych na temat „Allelomorphism”.

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1

Dogan, Ali. "CYP2C19*2 and CYP2C19*3 allelomorphism in Turkish population". International Journal of Cardiology 239 (lipiec 2017): 12. http://dx.doi.org/10.1016/j.ijcard.2017.01.103.

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Fujii, Kazuyuki, i Hiroshi Oike. "MULTI-ALLELOMORPHISM IN THE ABO BLOOD GROUPS BY BERNSTEIN REVISITED". Far East Journal of Mathematical Education 16, nr 3 (6.09.2016): 309–17. http://dx.doi.org/10.17654/me016030309.

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Amemiya, Miyoji. "Re-examination of Bernstein's corrections to the multi-allelomorphism in the ABO blood groups." Journal of the Japan Society of Blood Transfusion 34, nr 4 (1988): 391–99. http://dx.doi.org/10.3925/jjtc1958.34.391.

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4

Tantray, Javeed Ahmad, K. Pratap Reddy, Kaiser Jamil i Y. Shiva Kumar. "Pharmacodynamic and cytogenetic evaluation in CYP2C19*2 and CYP2C19*3 allelomorphism in South Indian population with clopidogrel therapy". International Journal of Cardiology 229 (luty 2017): 113–18. http://dx.doi.org/10.1016/j.ijcard.2016.11.217.

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5

Nachtsheim, Hans. "Polymerie und multipler Allelomorphismus bei der Vererbung der Milchergiebigkeit". Zeitschrift für Tierzüchtung und Züchtungsbiologie einschließlich Tierernährung 6, nr 1 (26.04.2010): 129–36. http://dx.doi.org/10.1111/j.1439-0388.1926.tb00300.x.

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6

Mogilenkova, Lyubov A., i V. R. Rembovskiy. "Role of genetic polymorphism and differences in the detoxification of chemical substances in the human body". Hygiene and sanitation 95, nr 3 (28.10.2019): 255–62. http://dx.doi.org/10.18821/0016-9900-2016-95-3-255-262.

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There are given modern views on the role of genetic polymorphism on the detoxification of chemical substances and individual sensitivity in workers to the development of diseases associated with xenobiotics metabolism disorders. In the search for genetic markers of occupationally caused diseases it is promising to study allelomorphs of genes responsible for the polyfunctional response of the human body, including genes involved in xenobiotic biotransformation. There is substantiated the expediency of compilation and introduction of genetic passports for stuff occupied at hazardous chemical enterprises.
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7

Doylidov, Viktor. "Determination of reproductive, fattening and meat quality of pigs with integrated genotypes of various DNA markers allelomorphis". Proceedings of the Kuban State Agrarian University 1, nr 69 (2017): 225–31. http://dx.doi.org/10.21515/1999-1703-69-225-231.

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8

Yu, Y. G., M. A. Saghai Maroof i G. R. Buss. "Divergence and allelomorphic relationship of a soybean virus resistance gene based on tightly linked DNA microsatellite and RFLP markers". Theoretical and Applied Genetics 92, nr 1 (styczeń 1996): 64–69. http://dx.doi.org/10.1007/bf00222952.

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9

Yu, Y. G., M. A. Saghai Maroof i G. R. Buss. "Divergence and allelomorphic relationship of a soybean virus resistance gene based on tightly linked DNA microsatellite and RFLP markers". TAG Theoretical and Applied Genetics 92, nr 1 (1.02.1996): 64–69. http://dx.doi.org/10.1007/s001220050093.

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10

Taylor, Daniel Kyle, Lisa F. Boyd, Jiansheng Jiang, Mike M. Mage, Peter Cresswell, David H. Margulies i Kannan Natarajan. "Analyses of the interactions of tapasin and ERp57-tapasin proteins with PaSTa 1 and PaSTa 2 antibodies and MHC-I molecules". Journal of Immunology 206, nr 1_Supplement (1.05.2021): 104.05. http://dx.doi.org/10.4049/jimmunol.206.supp.104.05.

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Abstract The intracellular loading of major histocompatibility complex class I (MHC-I) molecules with high affinity peptides is a pre-requisite for their cell surface display as ligands for T and NK cells. Peptide acquisition occurs in the ER within the peptide loading complex (PLC) and is accomplished through the concerted action of several proteins, most notably tapasin. In the absence of tapasin, peptide loading is compromised, resulting in decreased cell surface expression of some, though not all, MHC-I allelomorphs. In order to gain a mechanistic understanding of tapasin function as well as its apparent allelomorph specificity we have produced recombinant Fab fragments of two anti-tapasin antibodies, PaSTa 1 and PaSTa 2, and investigated their binding to human recombinant soluble tapasin and ERp57/tapasin by SPR methods. Both antibody Fabs bind with nanomolar affinities characterized by slow off rates. Based on these results we developed an MHC-I binding assay employing PaSTa 1-captured tapasin or ERp57/tapasin which reveals affinities in the micromolar range for selected MHC-I alleles. These affinities are notably weaker than those obtained for the structurally related but PLC-independent chaperone, TAPBPR (TAP-binding protein, related), and may reflect distinct evolutionarily derived functions for the two related molecules.
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11

Gunduz, Irfan, Glenn R. Buss, Pengyin Chen i Sue A. Tolin. "Genetic and Phenotypic Analysis of Soybean mosaic virus Resistance in PI 88788 Soybean". Phytopathology® 94, nr 7 (lipiec 2004): 687–92. http://dx.doi.org/10.1094/phyto.2004.94.7.687.

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Resistance to Soybean mosaic virus (SMV) was identified in PI 88788 soybean, a germ plasm accession from China that is used widely as a source of resistance to soybean cyst nematode. Strains SMV-G1 through -G7 infected the inoculated leaves of PI 88788 but were not detected in upper, noninoculated trifoliolate leaves. Inheritance of resistance was determined by inoculating progenies of crosses of PI 88788 with susceptible cvs. Essex and Lee 68 with SMV strains G1 and G7. Allelomorphic relationships with known genes for resistance to SMV were tested in crosses with the resistant genotypes PI 96983, L29, and V94-5152, possessing Rsv1, Rsv3, and Rsv4 genes, respectively. Data analyses showed that resistance in PI 88788 to SMV-G1 is controlled by a single, partially dominant gene; however, to SMV-G7, the same gene was completely dominant. The PI 88788 gene was independent of the Rsv1 and Rsv3 loci, but allelic to Rsv4 in V94-5152. Expression of the Rsv4 gene in PI 88788 resulted in a reduced number of infection sites and restricted short- and long-distance movement of virus, rather than hypersensitivity. A unique late susceptible phenotype was strongly associated with heterozygosity. This gene has potential value for use in gene pyramiding to achieve resistance to several SMV strains, as well as for rate-reducing resistance.
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12

Jiang, Jiansheng, Kannan Natarajan, Jessica Ingram i David H. Margulies. "Structure of a TAPBPR/nanobody complex reveals dynamic plasticity of unbound regions of TAPBPR". Journal of Immunology 200, nr 1_Supplement (1.05.2018): 99.17. http://dx.doi.org/10.4049/jimmunol.200.supp.99.17.

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Abstract Recently determined structures of the tapasin homolog, TAPBPR, complexed with peptide-receptive MHC-I molecules, revealed interaction of TAPBPR with the a2-1 helix of MHC-I, and displacement of the C-terminal region of the peptide binding groove, resulting in a conformation amenable to peptide loading. These structures were based on X-ray data at ~3.4 Å resolution and a number of regions of the electron density map were ill-defined. In an effort to obtain a higher resolution structure of TAPBPR, we isolated TAPBPR-specific nanobodies (camelid-derived single domain antibody fragments), from phage display libraries generated from peripheral blood lymphocyte mRNA of an alpaca immunized with TAPBPR. E. coli-expressed and purified nanobodies were complexed with TAPBPR. Crystal structures of a TAPBPR/nanobody complex and of nanobody alone were determined at 2.8 Å and 1.55 Å resolution respectively. In the structure of the complex the nanobody binds to the C-terminal Ig domain of TAPBPR, rigidifying the region of contact and thus permitting modeling of TAPBPR residues that were not visible in the reported TAPBPR/MHC-I structures. Unliganded surfaces of TAPBPR were more disordered than in the MHC-I liganded form. These data are consistent with the view that the luminal domains of TAPBPR, in solution, are structurally dynamic, and rigidify on ligand (i.e. MHC-I) interaction. Such structural plasticity may explain the ability of TAPBPR to interact with a variety of MHC-I allelomorphs.
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13

Yang, Qing, i J. D. Fan. "Topologic configuration of electron". Modern Physics Letters A 33, nr 26 (24.08.2018): 1850163. http://dx.doi.org/10.1142/s0217732318501638.

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Motion of an electron is much different from that of a kind of matter in classical mechanics. Although it is impossible to directly observe the configuration of a bare electron, it is never as simple as to treat it as a three-dimensional (3D) particle in the microscopic world because the electron itself certainly has its own topological configuration, so that it presents a field of a unit charge and a spin, etc. An electron produces a magnetic field in motion and also can radiate or absorb an electromagnetic field in its accelerating motions. Thus, the topological configuration of an electron must be related or similar to the configurations of the magnetic field and electromagnetic wave. Starting from the topological configuration of a single electromagnetic wave, it is possible to derive that an electron is a quantized left-hand Möbius strip, on the center of which there exists an anti-neutrino. The Möbius strip excites a [Formula: see text] circumference of a unit negative charge and a linear electric field of a [Formula: see text] torsion and can explain the wave feature of the electron and the essential cause of producing a magnetic field and radiating an electromagnetic wave as well as predict that the second-order tensor field among the three quarks in a proton has a topological configuration of right-hand three-leaf knot and can excite a [Formula: see text] circumference of a unit positive charge and a linear electric field of a [Formula: see text] torsion, which is just allelomorphic to an electron.
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14

Crook, Kenneth, i Simon V. Hunt. "Enrichment of Early Fetal-Liver Hemopoietic Stem Cells of the Rat Using Monoclonal Antibodies Against the Transferrin Receptor, Thy-1, and MRC-Oχ82". Developmental Immunology 4, nr 4 (1995): 235–46. http://dx.doi.org/10.1155/1995/85036.

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Fetal livers from inbred rat fetuses at 14 days' gestation were dispersed into a single-cell suspension by physical disruption and collagenase digestion. Pluripotent stem cells were characterized and partially purified by a combination of monoclonal antibodies. These included CD71 (anti-transferrin receptor, MRC-Oχ26, used for rosetting), Cdw90 (anti- Thy-1, MRC-Oχ7), and the newly described MRC-Oχ82 (reacting with myeloid cells in peritoneal exudate), employed in FACS sorting. Enrichment was monitored by long-term reconstitution of lethally irradiated congenic rats genetically distinguishable from the donor by an allelomorphic variant of the CD45 cell-surface antigen. At intervals from 3 months to 1 year, lymph-node cells and peritoneal exudate cells were biopsied for analysis by two-color flow cytometry-one color to determine donor origin, the other to identify Th cell (CD4+), Tc cell (CD8+), B cell (sIg+ or CD45RC+ ), neutrophil (Oχ82 + or Oχ43- ), and macrophage (Oχ43+) compartments. The degree of chimaerism was taken as the read out of stem-cell activity. No significant differentials between lymph-node and peritoneal exudate chimaerisms were detected in any of the recipients; therefore, the enrichment procedure revealed only pluripotent cells, not stem cells of restricted potency. All recovered stem-cell activity was in the Oχ26(CD71)-negative, Oχ7(CDw90)-positive, Oχ82-positive fraction. In the optimum case, an enrichment of very roughly 200-fold in cell-for-cell activity was obtained.Rat bone-marrow colony-forming units in the spleen (CFUs-12) were found to lack the surface antigens recognized by the monoclonal antibodies CD53 (MRC-Oχ44), MRC-Oχ39, MRC-Oχ59, and 144.2.15. These would provide a strategy for their enrichment by depletion.
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15

Taylor, Daniel Kyle, Jiansheng Jiang, Lisa F. Boyd, Peter Cresswell, Michael G. Mage, David H. Margulies i Kannan Natarajan. "Dynamic features of tapasin as revealed by structures of two tapasin/Fab complexes". Journal of Immunology 208, nr 1_Supplement (1.05.2022): 102.20. http://dx.doi.org/10.4049/jimmunol.208.supp.102.20.

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Abstract Intracellular loading of major histocompatibility complex class I (MHC-I) molecules occurs within the peptide loading complex and is accomplished through the concerted action of several proteins, including the chaperone/catalyst tapasin. In the absence of tapasin, peptide loading is compromised, resulting in decreased cell surface expression of some, though not all, MHC-I allelomorphs. To gain a mechanistic understanding of tapasin’s function we have produced recombinant Fab fragments of two anti-tapasin antibodies, PaSta1 and PaSta2, and investigated their binding to human recombinant soluble tapasin by surface plasmon resonance methods and X-ray crystallography. Both antibody Fabs bind with nanomolar affinities characterized by slow off rates. PaSta1 and PaSta2 recognize distinct epitopes as tapasin captured on a surface immobilized with one PaSta Fab binds the other PaSta Fab with nanomolar affinity. However, tapasin captured on a PaSta2 Fab surface is not able to bind peptide/HLA-B*44:05/beta-2 microglobulin complexes while tapasin captured on a PaSta1 Fab surface can, indicating that PaSta2 sterically competes for the MHC-I binding site. This finding was echoed in the structural characterization of PaSta Fab-tapasin complexes by X-ray crystallography. PaSta1 binds to an extended N-terminal region of tapasin, a site accessible even in the tapasin/ERp57 complex. By contrast, PaSta2 binds at the junction of the N-terminal and C-terminal domains of tapasin, where tapasin may interact with HLA-I molecules. Comparison of conformations of tapasin in complex with PaSta1, PaSta2, HLA-B*44:05, and ERp57 reveals the dynamic nature of tapasin, a versatile chaperone and catalyst. Supported by the intramural research program of the NIAID, NIH
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16

"Erratum to : RE-EXAMINATION OF BERNSTEIN'S CORRECTIONS TO THE MULTI-ALLELOMORPHISM IN THE ABO BLOOD GROUPS". Journal of the Japan Society of Blood Transfusion 34, nr 5 (1988): e1-e1. http://dx.doi.org/10.3925/jjtc1958.34.5_e1.

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17

Naaz, Neha, Sana Choudhary, Nidhi Sharma, Nazarul Hasan, Najla A. Al Shaye i Diaa Abd El-Moneim. "Frequency and spectrum of M2 mutants and genetic variability in cyto-agronomic characteristics of fenugreek induced by caffeine and sodium azide". Frontiers in Plant Science 13 (16.01.2023). http://dx.doi.org/10.3389/fpls.2022.1030772.

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Trigonella foenum graecum L. (Fenugreek) is a valuable medicinal plant cultivated for decades for its therapeutic characteristics. Still no pronounced improvement concerning wild form was accomplished as it is a self-pollinating crop. Induced mutagenesis is encouraged as a remarkable tool on this plant to circumvent the genetic bottleneck of cultivated germplasms. As a result, novel allelomorphic combinations for short-term agronomic attributes were developed. Fenugreek cultivar Pusa Early Bunching, selected for the present experiment, was mutagenized with five doses (0.2%, 0.4%, 0.6%, 0.8%, and 1.0%) of caffeine and sodium azide (SA) to evaluate its impact on the qualitative and quantitative traits of M1 and M2 generation conducted in a Complete Randomized Block Design (CRBD), replicated five times during 2019–2020 and 2020–2021, respectively. The frequency of induced phenotypic variations was assessed in M2 progenies, resulting in the identification and isolation of a broad spectrum of mutants with altered phenotypes. Mutagenic effectiveness and efficiency were found to be maximum at lower concentrations of the mutagen treatments and highest in SA, followed by caffeine. Various morphological mutants with modified characters were observed at different concentrations in M2 generation. The spectrum of mutations was wider in SA than in caffeine, as caffeine produced 51 while SA produced 54 individual mutants under seven major categories. The maximum frequency of morphological mutants was associated with leaf, followed by plant size, plant growth habit, pod, seed size, seed shape, and seed color. Morphological and structural variations in the guard cells of stomata and seeds were observed through scanning electron microscopy. The variations created in the economically important traits may enrich the genetic diversity of this plant species. Moreover, these morphological mutants may serve as a source of elite genes in further breeding programs of fenugreek.
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