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Ganesan, Parameshwari. "Investigation of Luminescent Properties in Rare-Earth free Metallophosphonate Hybrid Materials : structural Insights in photophysical studies". Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMC266.
Pełny tekst źródłaThis thesis work systematically investigates the structural and photophysical properties of rare-earth-free metallophosphonate hybrid luminescent materials, emphasizing the role of structure in luminescent properties. Metallophosphonates demonstrate exceptional versatility with their coordination chemistry, highlighted by their ability to interact with multiple metal centers and form robust P-O-M metal bonds. We aim to study crystalline organic-inorganic hybrid luminescent materials in which the organic part provides a rigid platform which is easily modifiable with various functional groups. we present various metallophosphonate hybrids synthesized through the hydrothermal route using functionalized organic ligands such as Fluorene, Thianthrene, and Tetraphenylethylene (TPE) phosphonic acid with different alkaline-earth elements (Mg, Ca, Sr, Ba) and transition elements (Mn, Co, Cu, Zn). Different metallophosphonate materials are obtained by manipulating the nature of molecules, the number of functional groups, and the characteristics of cations in the structure. Due to that, the synthesized metallophosphonate hybrid materials exhibit diverse structural properties, including rigidity, thermal stability, and different arrangements like face-to-face or edge-to-face and herringbone stacking patterns. Furthermore, these materials display intriguing luminescent properties, such as Fluorescence, Room Temperature Phosphorescence (RTP), Bathochromic and Hypsochromic shift (red and blue shift), Excimer emission, and other novel green and red luminescence bands, particularly in the presence of specific cations. Lastly, we discuss and explore the interconnection between structural and physical properties including the phenomena of Aggregation Induced Emission (AIE) and Aggregation Enhanced Emission (AEE) for hybrid compounds
Yu, Wai Hong. "Synthesis, Characterization and application studies of new aggregation-induced emission (AIE)-active materials". HKBU Institutional Repository, 2018. https://repository.hkbu.edu.hk/etd_oa/496.
Pełny tekst źródłaDong, Yujie. "Synthesis, photophysical properties and applications of aggregation-induced emission materials based on cyanostilbene moiety". HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/313.
Pełny tekst źródłaLau, Wai Sum. "Synthesis, characterization and application studies of cyanostilbene-based molecular materials with aggregation-induced emission (AIE) characteristics". HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/70.
Pełny tekst źródłaOhtani, Shunsuke. "Creation of Emissive and Functional Materials Based on Fused-Boron Complexes". Kyoto University, 2021. http://hdl.handle.net/2433/261618.
Pełny tekst źródłaIto, Shunichiro. "Synthesis and Photophysical Properties of Functional Luminescent Materials Based on β-Diiminate Complexes Composed of Main-Group Metals". Doctoral thesis, Kyoto University, 2020. http://hdl.handle.net/2433/245840.
Pełny tekst źródła0048
新制・課程博士
博士(工学)
甲第22155号
工博第4659号
新制||工||1727(附属図書館)
京都大学大学院工学研究科高分子化学専攻
(主査)教授 田中 一生, 教授 秋吉 一成, 教授 古賀 毅
学位規則第4条第1項該当
Doctor of Philosophy (Engineering)
Kyoto University
DGAM
Suenaga, Kazumasa. "Precise Control of Highly-Efficient Solid-Emissive Property of Boron Ketoiminate". Kyoto University, 2019. http://hdl.handle.net/2433/242531.
Pełny tekst źródłaKyoto University (京都大学)
0048
新制・課程博士
博士(工学)
甲第21793号
工博第4610号
新制||工||1718(附属図書館)
京都大学大学院工学研究科高分子化学専攻
(主査)教授 田中 一生, 教授 秋吉 一成, 教授 大内 誠
学位規則第4条第1項該当
Arribat, Mathieu. "Acides aminés phosphole ou silole : vers de nouvelles sondes fluorescentes pour un marquage de peptide innovant". Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTS144.
Pełny tekst źródłaThe first part of this work is focused on phospholyl amino acids synthesis by formation of a P-C bond. The fluorescent properties (absorption, emission and quantum yield) are modulated either by the substituent on the phosphorus atom (BH3, O, S, …) or by the aromatic skeleton of the phosphole. Peptide coupling in solution or on solid support were performed and showed the possibility to introduce such amino acids into peptide of interest. The second part of this work is dedicated to the synthesis of new functionalized phospholes for a chemoselective grafting on amino acid and peptides pendant groups (SH, NH2, OH) via PS, P-N or P-O bonds. The third part consists into the synthesis of a new class of tetraphenylsilole amino acids which exhibit AIE (aggregation-induced emission) fluorescent properties. Those compounds were successfully incorporated into di- an tri- peptides in solution and on solid support
Dong, Wenyue [Verfasser]. "The Design and Synthesis of Conjugated Polymers with Aggregation-Induced Emission and Their Application in Fluorescence Sensing / Wenyue Dong". Wuppertal : Universitätsbibliothek Wuppertal, 2015. http://d-nb.info/1076929885/34.
Pełny tekst źródłaDong, Lei. "Conception et synthèse de glyco-sondes fluorescentes pour des applications en détection". Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1153/document.
Pełny tekst źródłaWith scientific and social progress, various methods for the specific and sensitive detection of metals, proteins and other biomolecules are widely utilized in environmental protection, disease surveillance, drug therapy, agricultural production, industry and other significant areas. Fluorescent probes are widely developed based on ICT, PET, FRET and other fluorescence mechanisms, and applied to the detection of contaminants or in cell imaging. But the ACQ effect usually quenched the fluorescence intensity and thus limited the applications of organic probes in cell imaging and living systems. Therefore, the concept of aggregated-induced emission (AIE) appears as a possible solution to these problems and several fluorescent glycoclusters, glyco-probes and glyco-complexes were designed and reported for biological analysis. Our first project aimed to design and synthesize fluorescent glyco-polymers with multiple glycosides for cell targeting and drug delivery while fluorescence will allow the detection of the targeted cells. To overcome the ACQ effect and interference from natural biological background fluorescence, we conjugated dicyanomethylene-4H-pyran (DCM) and tetraphenylethene (TPE) to obtain near-infrared AIE fluorescent probes. The glycosides provided good water solubility and self-assembly in water led to detection systems and imaging cancer cells. TPE-based glycopolymers were synthesized from TPE monomers incorporating two monosaccharides by CuAAC conjugation and these monomers were polymerized by either CuAAC or thiol-ene “click” reactions. The TPE-based glycopolymers did not display a large chain length (typically less than 7 units) and the expected fluorescent properties could not be reached. We then designed and synthesized glyco-dots self-assembled by DCM probes and TPE-based glycoclusters. The glyco-dots displayed high water-solubility and selective response to peroxynitrite (ONOO-) both in vitro and in cell assays. The glyco-dots could detect endogenous and exogenous ONOO- but no specific cell recognition. We designed and synthesized AIE fluorescent probes which could self-assemble with TPE-based glycoclusters. The resulting glyco-dots were readily water soluble and displayed excellent sensitivity and selectivity for thiophenol detection in vitro and in environmental water samples. We finally combined both TPE and DCM moieties to synthesize a novel AIE fluorophore (TPE-DCM) with long-wavelength emission. Then conjugation with glycosides through CuAAC led to AIE fluorescent probes with long-wavelength emission, excellent water-solubility. Application to the detection of glycosidases in vitro and in cell assays or animal models was possible with these probes
Viglianti, L. "THE HETEROARYLETHENES: SYNTHESIS, ELECTROCHEMISTRY AND INVESTIGATION ON THE AGGREGATION-INDUCED EMISSION OF A PROMISING CLASS OF MOLECULES WITH LUMINESCENT PROPERTIES". Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/338784.
Pełny tekst źródłaTominaga, Masato. "Functional π-Conjugated Materials Based on Structure of o-Carborane". 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188607.
Pełny tekst źródłaUpamali, Karasinghe A. Nadeeka. "Carbazole-Based, Self-Assembled, Π-Conjugated Systems As Fluorescent Micro And Nanomaterials - Synthesis, Photophysical Properties, Emission Enhancement And Chemical Sensing". Bowling Green State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1323099511.
Pełny tekst źródłaZhang, Wanying. "Comprehensive Study on Fluorescent ESIPT Liquid Crystal Materials and the Potential for Optoelectronic Applications". Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263621.
Pełny tekst źródłaYoshii, Ryosuke. "Synthesis of Highly-Functional Polymers Using Characteristics of Four-Coordinated Boron-Complexes with Boron-Nitrogen Bonds". 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/188610.
Pełny tekst źródłaGrolleau, Jérémie. "Synthèse de nouveaux semi-conducteurs organiques par arylation directe". Thesis, Angers, 2016. http://www.theses.fr/2016ANGE0029/document.
Pełny tekst źródłaResearch on organic photovoltaics over a decade allowed a steadily increasing in the efficiency of solar cells. Several research groups have begun a reflection on the synthesis processes to limit wastes. Thus the direct arylation coupling which avoids the use of organometallic compounds, has emerged as an example of green reaction. The first part is devoted to the methodological study of direct arylation of bromotriphenylamine with thiophene-2-carboxaldehyde derivatives substituted in C3 and C4 by electron-withdrawing groups and electron-donor groups. This basic pattern allows access to three small molecules by condensation. Photovoltaic cells reaching photoconversion efficiencies of 3% were obtained. In the second part, the polymerization by direct arylation of sustituted thiophene monomers by nitrile groups as the acceptor and by alkoxy or thioalkyl as the donor led in one step to a novel family of conjugated polymers having donor and acceptor groups alternately. Solar cells were made with the polymers as donors or as acceptors materials. Finally, in the last part, exploratory work on the emission properties of benzofuran derivatives have been made. Knoevenagel condensations have been developed for a range of compounds containing the cyano-vinylbenzofuran unit. Most compounds have high emission in the solid state
Cousins, Morgan. "I. Designing Brighter Fluorophores: A Computational And Spectroscopic Approach To Predicting Photophysical Properties Of Hydrazone-Based Dyes Ii. Developing Spectroscopic Methods To Better Understand The Cofactors Of Metalloproteins". ScholarWorks @ UVM, 2017. https://scholarworks.uvm.edu/graddis/787.
Pełny tekst źródłaXie, Sheng. "Perfluroaryl azides : Reactivities, Unique Reactions and their Applications in the Synthesis of Theranostic Agents". Doctoral thesis, KTH, Organisk kemi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-172950.
Pełny tekst źródłaQC 20150903
Andreiuk, Bohdan. "Self-assembly of ionic fluorescent dyes inside polymer nanoparticles : engineering bright fluorescence and switching". Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAF027/document.
Pełny tekst źródłaEncapsulation of ionic dyes with help of bulky hydrophobic counterions into polymer nanomaterials emerged as powerful method for generating ultrabright fluorescent nanoparticles (NPs) for bioimaging. Here, this counterion-based approach is extended to cyanine dyes, operating from blue to near-infrared range. Based on cyanine-loaded NPs, a multicolour cell barcoding method for long-term cell tracking is developed. Second, the role of bulky hydrophobic counterion in self-assembly of cationic dyes inside polymeric NPs is studied by testing a large library of anions. We show that high hydrophobicity of a counterion enhances dye encapsulation, prevents particle aggregation and tunes dye clustering, while large size prevents dyes from self-quenching. Third, counterions based on aluminates and barbiturates are shown to outperform fluorinated tetraphenylborates. This work provides a solid basis for counterion-enhanced encapsulation and emission concept in preparation of dye-loaded fluorescent NPs
Yu, Tingting. "Solid state luminescent molecules, macromolecules and materials, their response to stimuli and their applications in devices". Thesis, Lyon, 2020. http://www.theses.fr/2020LYSEN061.
Pełny tekst źródłaIn this thesis, we developed new luminescent conjugated chromophores presenting an alternation of electron donor and acceptor groups, with a specific focus on their emission properties in aggregates or solid states in far-red or near infrared region. We studied the influence of chain length and donor/acceptor substitution not only on the optical properties of the isolated compounds, but also (and especially) on the material in its aggregated state. Finally, taking advantages of these specific properties of some of the as-designed candidates, we explored their potential applications ranging from fluorochromic stimuli-responsive sensors (in film form) to red and NIR luminescent two-photon probes for biological imaging. The main achievements of this thesis are the following: 1) new alternating triarylamine or carbazole / tetraphenylethylene (TPE) polymers were synthesized. Their solid state luminescence poseeses typical J-aggregates emission features in solid state, unusual in TPE derivatives that we relate to the linear polymeric nature of the object; 2) A new family of diphenylamine / benzobisthiazole chromophores and derived oligomers were synthesized . Their luminescence properties present a marked sensitivity to protonation, which we took advantage of in the making of acid-base responsive luminescent devices; 3) we explored the possibility of additional chemical transformations of the newly designed chromophore, in order to achieve solid state NIR emission, in particular by means of a change in the character of the electronic transition from Intra-Molecular Charge Tranfer (ICT) to Cyanine transition owing to benzothiazole quaternarization. Other modifications resulted in improvement of their AIE properties, bioavailability and selectivity of their cellular compartments staining ability; 4) These new compounds present a reversible photoinduced “on-off” switching of their luminescence properties, which might present an interest in the design of contrast-agents for super resolution imaging
Rouillon, Jean. "Chromophores présentant une émission à l'état solide induite à deux photons : synthèses et études de la dynamique des états excités en solution et en agrégats". Thesis, Lyon, 2020. http://www.theses.fr/2020LYSEN057.
Pełny tekst źródłaThe design of biocompatible nano-objects used in fluorescence microscopy represents a major interest. In this perspective, chromophores with two-photon absorption (A2P) and aggregation induced emission (AIE) properties have been synthesized, derived from an extended tetraphenylethylene (TPE) base. The study of the influence of the stereoconfiguration (Z or E) of this family of molecules on their self-assembly established a link between crystallinity and fluorescence of the aggregates, and nano-objects were optimized for in vitro and in vivo imaging applications by two-photon fluorescence microscopy.The mechanisms behind the AIE properties of TPEs, still debated in the literature, have been rationalized by a detailed photophysical study made possible by the development of a new actinometric NMR method. The functionalization of one of the chromophores by a hydrophilic polymer block leading to a self-assembly in micellar form in aqueous medium was done to obtain luminescent nano-objects of a new type, which have been used as DNA specific probes. Finally, a new methodology for the stereoselective synthesis of AIEgens of the ditriazolostilbene (DTS) family was proposed, paving the way for versatile molecular engineering based on azide-alkyne cycloaddition
Yang, Chih-Min, i 楊智閔. "Ionic Luminogen with Aggregation-Enhanced Emission". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/13225030049700524989.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
101
Restricted intramolecular rotation (RIR) of the non-coplanar aromatic fluorophores has been proven in several instances as the operative mechanism leading to the aggregation-enhanced emission (AEE) property. Besides using the bulky substituent as structural moiety of AEE-active materials, ionic bond interaction is also considered to be effective in reinforcing RIR. In this study, ionic ammonium sulfonate bond was used to introduce long chain orientation order and thus to impose effective RIR to generate emission enhancement on AEE-active organic fluorophores. With this aspect, a surfactant (surf) molecule of weakly-luminescent dodecylbenzenesulfonic acid (DBSA) was used to complex to different amines of varied structures and certain diamines (piperazine (PZ) and poly(ethyleneimine (PEI)) with right geometry to generate orientated dodecyl chains in the ionic products result in the further emission intensifications of the complex systems. Additionally, long-chain dodecylamine (DA) was used to react with weakly-fluorescent biphenyldisulfonate (BPS) and poly(styrene sulfonate) (PSS) to generate AEE-active materials with required orientation order and strong fluorescence due to the active RIR effect. An interesting aggregation-enhanced excimer emission (AEEE) was observed specifically for PSS(DA)1 complex system. Several complex systems (such as DBSA(PZ)x, DBSA(PEI)X, BPS(DA)x and PSS(DA)x ) were found to self-assemble into well-ordered supramolecular lamellar structures with the preferable orientation orders among their long aliphatic chains. RIR in relation to orientation order is therefore the main focus of this research.
Chien, Wei-Lun, i 簡偉倫. "Anthracene-Based Luminogen with Aggregation-Enhanced Emission". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/04019539460649668011.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
101
In regards to the role of H-bond interaction as restriction forces on molecular rotation, we thereby explore further possibilities of using this facile strategy to generate AEE-active fluorescence systems with enhanced emissions. We used typical Heck coupling reaction to synthesis two different systems based on the facile H-bond interaction between H-bond donating hydroxyl and H-bond accepting pyridine functions are illustrated in this research. In chapter 2, an AEE-active dipyridine fluorophore was used to H-bond to monomeric diphenol (bisphenol A, BPA) and poly(vinyl phenol) (PVPh) to generate pseudo-linear and crosslinked systems, respectively, with beneficial AEE-active strong fluorescence. Instead of diphenol fluorophore, AEE-active diphenol compound was used in Chapter 3 as the fluorescent component to react with poly(vinylpyrrolidone) to generate peudo-crosslinked network with strong fluorescence. Both systems described in Chapter 2 and 3 are all subjected to different instrumentation analyses to identify the restricted molecular rations and the related enhanced emissions.
Teng, Siang-ling, i 鄧湘霖. "Ionic Interaction in Fluorescent Complexes with Aggregation-Enhanced Emission". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/43ea53.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
102
Abstract-1 A fluorescent biological sensor utilizing aggregation-enhanced emission (AEE) property was developed in our laboratory. First, anAIE-active fluorescent tetraphenylthiophene (TP) unit was synthetically connected to poly(N-isopropylacrylamide) by covalent and ionic bonds, resulting in the respective c- and i-TP-PNIPAM for the detection and quantification of the bovine serum albumin (BSA) model protein. When bind to BSA, the ionic i-TP-PNIPAM shows much better fluorescence (FL) sensitivity compared to c-TP-PNIP AM. The fluorescence (FL) intensity of i-TP-PNIAPM displays a good linear dependence on concentration of BSA (0 – 1 mg/mL), indicating quantitative fluorimetric protein detection can be achieved. Further addition of anionic surfactant ofsodium dodecylsulfate (SDS) considerably raised the FL intensity of the complexsolution. All the FL response was discussed in term of conformational freedom of the TP unit under different environmental constraints. Abstract-2 A water-soluble fluorophore containing four anionicsulfonated groups, sodium tetraphenylthiophenesulfonate (TPS), was sythesizedand characterized to have aggregation-enhanced emission (AEE) property. One the other hand, acidified Jeffamine (diammonium-terminated poly(propylene glycol) and Jeffamine-included β-cyclodextrin (β-CD) were separatedly prepared. Through the facile ionic interaction between sulfonate anion in TPS and ammonium cation in Jeffamine (or in Jeffamine-included β-CD), fluorescent ionic complex of iTP-JA (or iTP-CD-JA) can be prepared and their emission behavior was correlated with the degree of restricted intramolecular rotation (RIR), as the main mechanism responsible for AEE phenomenon, in each system of different molecular structures. When bind to polymeric Jeffamine, iTP-JA complex emits with higher intensity than the small-mass TPS. Use of β-CD rigidify the flexible Jeffamine, therefore, iTP-CD-JA complex is the most efficient emitter among all three samples.
Chen, Tai Lin, i 陳泰霖. "Aggregation Enhanced Emission and Piezochromism of Nitrogen Containing Heterocyclic Luminogen". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/42063937618355335109.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
101
Abstract - 1 Two tri-armed piezofluorochromic compounds of tris(4-(4-phenylquinolin-2-yl)phenyl)amine (TPA-3Qu) and tris(4-(6-(9H-carbazol-9yl)-4-phenylquinolin-2-yl)phenyl)amine (TPA-3QuCz) were prepared and found to exhibit keen fluorescence responses toward pressurization. With the framework of a twisted, pyramidal triphenylamine (TPA) center connecting to three large quinolinecarbazole (QuCz) arms, TPA-3QuCz is amorphous material exhibiting a large bathochromic shift of 112 nm under gentle grinding forces, which is in widely contrast to the small shift of 32 nm for TPA-3Qu when subjected to a high pressure load of 10 MPa. By heating to high temperatures, both TPA-3QuCz and TPA-3Qu also exhibited the same bathochromic shifts as pressurization did. Conformational transformations involving planarization of the arms were proposed to account for the observed fluorescence responses of TPA-3QuCz and TPA-3Qu towards pressure and heating. Abstract -2 In this study, organic molecules of 4,4''-((1E,1''E)-((3,4-diphenylthiophene-2,5-diyl)bis(4,1-phenylene))bis(ethene-2,1-diyl))dipyridine (TP-2Py) with smaller substituent and 4,4''-((1E,1''E)-((3,4-diphenylthiophene-2,5-diyl)bis(4,1-phenylene))bis(ethene-2,1-diyl))bis(N,N-diphenylaniline) (TP-2TPA) with stronger substituent were prepared and characterized to identify their photoluminescent (PL) responses toward the effect of aggregation emission enhancement (AEE). Comparing the fluorescence intensity for TP-2Py and TP-2TPA , no matter in the solid or solution state, the fluorescence of TP-2TPA is stronger than the TP-2Py. By the study influence of temperature on solution emissions of TP-2Py and TP-2TPA, and computer simulation, we realized the compound of TP-2TPA which could effective restriction on molecular rotation than the compound of TP-2Py. With the effector of effective restriction on molecular rotation, TP-2TPA can block the non-radiative energy loss, to enhance the efficiency of luminescence. In another way, we also blends with hydroxyl-containing components (poly( vinyl alcohol) (PVA)) on both compounds,TP-2Py and tp-2TPA,. After blending with the hydroxyl components, the fluorescence can be further intensified due to the further restricted molecular rotation, though the facile intermolecular hydrogen-bond (H-bond) interactions between the nitrogen containing heterocyclic and the hydroxyl functions.
Lin, Li-yang, i 林利陽. "Polypeptides containing luminescent units with aggregation-induced emission property". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/j25965.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
103
First chapter: Tetraphenylthiophene (TP) with aggregation-enhanced emission (AEE) property was used as terminal fluorophore of the water-soluble poly(γ-propargyl-L-glutamate) (PPLG)-based polymers of TP-PPLG-g-MEO2. In this study, we research various TP-PPLG-g-MEO2 affect aggregation of luminescence. In water, when concentration of TP-PPLG-g-MEO2 achieve CMC, TP-PPLG-g-MEO2 will aggregation to nanoparticle and suddenly increasing emission, and when heating over LCST, TP-PPLG-g-MEO2 will contract and also enhance emission. We use TP-PPLG-g-MEO2 “salt out effect” property to probe salt in water, salt have interaction with side chain MEO2 and peptide main chain to make TP-PPLG-g-MEO2 contract together and change secondary structure to b-sheet conformation to enhance emission. In the strong alkaline media, TP-PPLG-g-MEO2 backbone change to random coil conformation that break intramolecular hydrogen bonding and loss LCST property, TP-PPLG-g-MEO2 become is a micelle like structure, core was hydrophobic TP and shell was hydrophilic polypeptide and particle size about 500nm measure by DLS. In random coil conformation, chain end hydrophobic TP have strong aggregation than in the a-helical and have strong aggregation emission peak. At last, we use TP-PPLG-g-MEO2 to detect BSA. When TP-PPLG-g-MEO2 mixture with BSA, TP-PPLG-g-MEO2 will fall in to BSA and separate to decrease TP-PPLG-g-MEO2 aggregation and emission. Second chapter: We synthesis polypeptide contain TPA pendent by click reaction. The resulting PPLG-g-TPA contains the crystalline TPA side groups, Tm about 145 oC and is therefore high Tg materials with the desired AIE activity. Due to side chain TPA, PPLG-g-TPA have piezofluorochromic property that have two color between crystal and amorphous state. The lone pair electrons of nitrogen atom in TPA side groups inherit PPLG-g-TPA the sensitivity toward acid HCl and metal ions. Emission of PPLG-g-TPA was progressively decreased upon increasing the amounts of HCl and metal ions in the solutions that can be acid or metal ions sensor.
Chang, Jui-Wen, i 張瑞文. "Aggregation-Induced Emission Characteristics of Tetraphenylethene-Capped Dipeptide Materials". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/43nzds.
Pełny tekst źródła國立交通大學
材料科學與工程學系所
103
Supramolecular self-assembly hydrogel materials is ubiquitous in materials science and biology. Self-assembly provides routes to a range of materials with regular structures. And others advantages to developed in this process. In this thesis, we developed the novel dipeptide supramolecular hydrogel with self-assembly gelation enhanced fluorescence emission. Tetraphenylethene (TPE) is almost non-emissive when molecularly dissolved in solution but turns to be highly fluorescent in aggregate states. The hydrogelator was constructed by using the TPE as the hydrophobic part and four different dipeptide (Gly-Gly、 Ser-Ser、 Asp-Asp and Tyr-Asp) as the hydrophilic component. We investigated these amphiphilic low-moleculars weight of the gelation pH value, performance of rheology, morphology and optical properties of the AIE characteristics. Each of the luminophore hydrogels has received different interesting results: TPE-GG is the minimum molecular weight of TPE-capped peptide forms the supramolecular hydrogel. TPE-SS is the minimum molecular weight of TPE-capped peptide forms the supramolecular hydrogel under neutral condition. TPE-DD could form the hydrogel under the acid condition(pH value= 4.3) and could be a pH sensor. TPE-YD can form the strongest hydrgel under the acid condition(pH value= 4.3) and also can form stable hydrgel under neutral condition. TPE-SS and TPE-YD can form hydrogel under neutral condition. These materials are potentially useful for develop 3D cell culture in the future. TPE-DD could change the emission properties under different pH values, which may be promising a biomaterial as an active element of biosensors.
Chen, Jyun-Wei, i 陳俊瑋. "Novel Aggregation-Induced Emission Fluorophores Applied on Cellular Studies". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/88facz.
Pełny tekst źródła國立中興大學
化學工程學系所
106
In this study, we focused on developing the newly organic molecules on the therapy and diagnosis of cancers. In the experiments, we synthesized some simple fluorescent organic molecules and enhanced their performances in the cells by the unique properties of Aggregation-Induced Emission (AIE). First, we synthesized an asymmetric 1, 6-disubstituted naphthalene (NV-12P), which can generate particular reactive oxygen species to undergo type I photodynamic therapy under irradiation. Furthermore, this compound can specifically localize in mitochondria in cancer cells to exhibit selective dark cytotoxicity, and exhibit efficient photodamage in cancer cells due to intracellular bright spots. Results suggested that this compound can be a potential dual-toxic efficacy molecule. Additionally, a water-soluble pH sensor ADA was designed and synthesized based on the molecular design of photo-induced electron transfer (PET) and intramolecular charge transfer (ICT). The fluorescent emission response against a pH value located in the range of 3~6, which is suitable to label intracellular pH dependent microenvironments. Finally, we not only used ADA to identify intracellular pH gradients between different cell lines, but also developed ADA as a fluorescent molecule that labeled normal cells by the unique fluorescence intensity of ADA in normal cells, making it effective as the control group at the time of cancer diagnosis.
Mandal, Kuheli. "Fluorescent Bioimaging Probe from Aggregation Induced Emission Active Molecule". Thesis, 2019. http://hdl.handle.net/10821/8341.
Pełny tekst źródłaShih, Ke-Ying, i 施克穎. "Specific interaction in fluorescent polypeptide: aggregation-enhanced emission and conformational transformation". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/d9h5w8.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
102
Abstract-1 New pyridine-terminated fluorophore of 4-[2-(9-Anthryl)vinyl]pyridine (AnPy) with intramolecular charge transfer (ICT) and aggregation-induced emission (AIE) properties was synthesized and was blended with different amounts of polytyrosine (PTyr) through preferable hydrogen-bond (H-bond) interactions. In blends of low AnPy content, the rigid PTyr peptide chains serve as templates to H-bond to AnPys, imposing rotational restriction and reinforcing the AIE-related emission intensity of AnPys, resulting in amorphous blends with the observed glass transitions dependent on the composition of the blends. In contrast, when large amounts of AnPys were added, excess AnPys will form new crystals, in between the amorphous regions, constituted by the near parallel dimers of AnPys. With the hampered molecular rotation, the parallel dimers of AnPys in the highly AnPy-loaded blends emit strongly with intensity much higher than those for the amorphous blends. In this study, conformation of the blends and degree of restricted molecular rotation were assessed in order to correlate with the AIE-related fluorescence behaviour. Abstract-2 Tetraphenylthiophene (TP) with aggregation-enhanced emission (AEE) property was used as terminal fluorophore of the water-soluble poly(γ-propargyl-L-glutamate) (PPLG)-based polymers of TP-iPPLGs to probe the relationship between the secondary structure (α-helix) of polypeptides and the AEE-related emission behavior. Intermolecular aggregation of the terminal TP unit in TP-iPPLG is sterically blocked by the large α-helical PPLG chains, leading to the weak AEE-related fluorescence in water. In contrast, the intermolecular approach between the terminal TP units of TP-iPPLG is accessible if TP was connected by peptide chin in random coil structure. Therefore, helix-to-coil transition induced in the alkaline aqueous solution successfully enhances the emission intensity of the TP-iPPLG solution. The pH-induced conformation change in relationship to the AEE-related emission behavior is therefore evaluated in this study.
LIN, YUN-RU, i 林韻茹. "Investigation of Aggregation-Induced-Emission Behavior for Tetraphenylethylene-Based Polymer". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/j97wv6.
Pełny tekst źródła逢甲大學
化學工程學系
105
In this study, we successfully synthesized a small molecules with tetraphenylethylene as the basic structure and the correspounding polymer. Two methods were tested when small molecules was synthesized. The product synthesized by McMurry reaction found to be a good method for the synthesis of small molecules. The molecules were polymerized to obtain the corresponding macromolecule materials. Then, the absorption spectra, fluorescence spectra, aggregation-induced emission effect and quantum yield were measured, respectively. The results showed that the absorption and fluorescence peaks of polymer were bathochromic shifted as conjugation chain was increased. The size of the polymer gradually increased with the increasing of the water fraction of solvent and begins to decrease after the water fraction reach 70% water percentage. The result agrees with the fact that the smaller size particle favor closer packing of polymer molecules and showed brighter fluorescence. In the polymer systems, the intramolecular rotations of the phenyl rotors are already partly restricted at molecular level due to the steric effect of polymer chains. Finally, the thermal stability was measured, the Td was 380℃, and the polymer showed nice thermal stability.
CHEN, PIN-RUEI, i 陳品叡. "Aggregation-induced emission in tetrasubstituted tetraphenylethene derivatives: synthesis and characterization". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/kj8s8y.
Pełny tekst źródła逢甲大學
化學工程學系
107
Luminescent materials with aggregation-induced emission (AIE) properties have attracted many people's interest in recent years due to their application in, optoelectronic components, fluorescent probes, chemical sensor, and biosensor. Tetraphenylethene (TPE) is a compound that often used to investigate luminescence properties with significant AIE. In this study, TPE derivatives 9, 14, 15, 16, 18a-d with tetra-substituted structure were successfully synthesized, and their absorption spectra, fluorescence spectra, aggregation-induced luminescence, liquid fluorescence quantum yield and electrochemical properties were studied. Based on the red-shift of absorption and fluorescence spectra for compounds 14, and 15, the conjugation growth was observed. In the aggregation-induced emission test, it was found that the fluorescence intensity increased with decrease of the solution solubility, and red-shift of fluorescence occurred. The compound 14, with Tetramethyl silane (TMS) substituents, showed the highest fluorescence quantum yield (56.7%). Moreover, different alkyl chains led to different fluorescence quantum yield. The oxidation potential of the compounds was determined by cyclic voltammetry and the energy of the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) was estimated. The thermal decomposition temperatures of the compounds were above 300oC revealing good thermal stability.
CHNEG, HAN-HUNG, i 鄭翰鴻. "Synthesis and Analysis of Tetraphenylethylene Derivative Exhibiting Aggregation-Induced Emission Property". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/40917032054723533120.
Pełny tekst źródła逢甲大學
化學工程學系
105
Aggregation-induced emission (AIE) have been widely uesd and developed, such as biotechnology, chemical technology, electrochromic, organic light-emitting diodes, and others. In this work, a AIE-active tetraphenylethylene derivative consist of long carbon chain and bromo group have been successfully synthesized. This compound only faintly emit in solution but show strong emission in aggregated state. The photoluminescence progressively increases during increasing the water content. In the THF/water mixture with 90 % water, the photoluminescence intensity is about 16 times increased if compared to pure THF. On the other hand, we observed that the particles are aggregated in the THF/water mixture with 60 % water. This result can be provided to associate with AIE-active.
Yang, Deng-Jie, i 楊登傑. "Self-assembly of responsive polymers containing luminogen with aggregation-induced emission property". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/f3ufh6.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
103
In chapter 1, tetraphenylthiophenen (TP) with aggregation-emission enhancement (AEE) property is served as terminal fluorophore of poly (acrylic acid) (PAA) based polymer of TP-PAA by atom transfer radical polymerization (ATRP) and hydrolysis reaction to probe the relationship between pH-induced conformation change and the AEE-related emission behavior, and the detection of the bovine serum albumin (BSA) model protein. Intermolecular aggregation of the terminal TP unit in TP-PAA is sterically blocked due to the carboxyl groups of the poly (acrylic acid) were involved in H-bonding, leading to the weak AEE-related fluorescence in the neutral aqueous solution. In contrast, the carboxyl group of the poly (acrylic acid) become deprotonated, leading to a strong electrostatic force limiting the hydrogen bonding and results in the terminal TP units in TP-PAA can easily approach each other to form aggregates with strong the emission intensity in the alkaline aqueous solution; The water-soluble TP-PAA were blended with BSA forming complexes due to hydrophobic interactions shows a sensitive and selective fluorescence enhancement property for protein detection. In chapter 2, as restricted intramolecular rotation (RIR) is the key leading to the aggregation-enhanced emission (AEE) property. We propose that luminogenic unit connecting polymer chains is particularly clumsy in rotation in considering that the bulky polymer chains are effective in hampering the rotational freedom of the luminogenic unit connecting to them. To test this idea, we synthesized tetraphenylthiophenen (TP) with aggregation-emission enhancement (AEE) property is served as central fluorophores of sodium polystyrene sulfonate (PSS) based polymer of TP-PSS. We used PL spectroscopy to study AEE phenomena for TP-PSS in solution/solid state and solvent/nonsolvent pair, respectively; we can use the sulfonate side groups of TP-PSS characteristics containing short-range interactions and ion exchange to detect pH value and remove calcium to achieve water softing.
Sing-HuaSu i 蘇星華. "Fluorescent Copolymers with Aggregation-Induced Emission: Synthesis, Nanofiber Fabrication and Sensing Applications". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/3xequw.
Pełny tekst źródła國立成功大學
化學工程學系
105
Electrospinning (ES) is a simple and versatile method for manufacturing continuous nanofibers. ES nanofibers with their large surface-to-volume ratio are widely used for various applications. In this study, novel fluorescent ES nanofibers are successfully prepared from random copolymers of poly(NIPAAm-co-NMA-co-(PPS-HEMA)) through free radical polymerization and followed by electrospinning for optical applications. PNIPAAm segments with thermo-responsive properties exhibit a hydrophilic-hydrophobic change as the temperatures varied. PNMA segments with chemically cross-linking moiety stabilize the morphology of nanofibers in the solution after thermal cross-linking. PPS-HEMA segments with aggregation-induced emission (AIE) phenomenon show much weaker emission in a good organic solvent. Upon aggregate formation, the emission of these AIE dyes is induced to increase by the effect of the restricted intramolecular rotation. The morphology of nanofibers before/after cross-linking were observed by Field Emission Scanning Electron Microscopy (FE-SEM). The high surface-to-volume ratio of ES nanofibers enhanced the sensitivity compared with that of spin-coating film. Furthermore, the optical measurements of ES nanofibers were reusable for several times.
Lin, Yu-Chun, i 林泑君. "Supramolecular Nanostructures with Aggregation-Induced Emission Characteristics and their Applications in pH Sensors". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/p4vxbc.
Pełny tekst źródła國立交通大學
材料科學與工程學系所
103
In this study, we have synthesized a series of peptide-based low molecular weight hydrogelators. This thesis has two-fold part. In the first part, a new class of organic hydrogelators are developed. These three-dimensional hydrogels contain nanofibrous structures with average widths of ca. 10-12 nm, which prepared via self-assembly of small molecules (PFB-dipeptides) in water. The PFB-dipeptide is weakly fluorescent in solution, but the intensity is increased by almost ~200-fold in the assemblies. The aggregation-induced emission (AIE) in the PFB-dipeptide nanostructures is unusual because there is no AIE-capped moiety in the molecule. The origin of the unusual AIE character is attributed to the side chain steric and hydrophobic effects of amino acids in the structure of PFB-dipeptides and the presence of intermolecular J-type quadruple-quadruple interactions of perfluoropheny-phenyl pairs between the PFB-dipeptides in the assemblies. This work illustrates the importance of the structure-property relationship on the development of new nanoscience and self-assembly nanomaterials. In the second part, a new series of self-assembled peptide nanostructures based on naphthalimide were synthesized and studied, the materials have significant differences in their fluorescence intensity, which have a higher emission peak at acidic conditions. Cell imaging was observed small spherical organelles (lysosomes) in live human prostate cancer PC-3 cell line and significant colocalizations (84.14 ± 2.99 %) of the sensor ppNI-FDGEA with a commercial available Lysotracker Red DND-99 probe by confocal fluorescence microscopy. This design template may also be used to synthesize other functional peptide sequences with potential applications in tissue engineering.
Li, Yi-wei, i 李逸維. "Aggregation-Induced Emission Enhancement of organic and polymeric fluorophores containing 2,4,6-Triphenylpyridine moiety". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/60225039021678798674.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
100
In this study, organic and polymeric fluorophores based on 2,4,6-triphenylpyridiene (TPP) structure were found to have the novel aggregation-induced emission enhancement (AIEE) property. For the small-mass fluorophores, TPP and cyano-functionalized TPP (TPP-CN) were prepared from the facile Chichibabin reaction and their AIEE properties were characterized by the emission behavior in solvent/nonsolvent pair. Solid samples of TPP and TPP-CN exhibit enhanced emission with increasing annealing time under solvent vapors, thus, both compounds have the characters of crystallization-induced emission enhancement (CIEE) behavior. For polymeric system, copolymers PTPPF containing alternative TPP and 9,9-dioctylfluorene units were prepared through Suzuki coupling and study on its fluorescence behavior also reveals its AIEE feature. The rigid polymer possesses high emission intensity in its dilute solution state and remains almost unchanged with increasing nonsolvent fraction. The solid sample was found to have a high quantum yield (ФF) of 70 %.
Chen, Huan-Wen, i 陳煥文. "Synthesis, Identification of Structure, and Fluorescence Characterization of Aggregation-Induced Emission of Materials". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/83768997252549351644.
Pełny tekst źródła國立中央大學
化學學系
102
In this study, we synthesized a serious of fluorophore with various donor and acceptor substituents. The longer emission wavelength fluorophore can be adjusted by molecular design which nonplanar conjugated structure could restrict intramolecular rotation in solid state. Moreover, aggregation-induced emission phenomenon will be found in nonplanar conjugated structure. On the other hand, we added dicyano-substituented with dithiophene fluorophore to test their aggregation-induced emission behavior. In addition, the thermal properties and the energy level of HOMO and LUMO were estimated by thermogravimetric analyzer, differential scanning calorimeter, cyclic voltammetry, and low-energy photoelectron spectrometer, respectively. Finally, the density functional theory and time-dependent density functional theory to imitate the orbital and energy levels of HOMO and LUMO.
Chien, Rong-hong, i 簡榮宏. "Aggregation-induced emission of organic compounds and polymers containing fluorene or tetraphenylthiophene ring". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/43488579296445205463.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
99
Traditional organic chromophores and polymers with disc-like, coplanar geometry tend to be highly emissive in the dilute solutions but become weakly luminescent in the concentrated solution and solid states. On the contrast, conventional chromophores (such as silole) with non-coplanar structure exhibit strong fluorescence in the concentrated states due to the aggregation-induced emission (AIE) or AIE enhancement (AIEE) effect originated from the restricted intramolecular rotation (RIR) inherent from the chemical structures of the luminescent materials. To verify the influence of RIR on the AIEE properties, four approaches were attempted in this research. First, copolymers PFN with alternative fluorene-naphthol unit was prepared through facile Suzuki coupling and was characterized to have AIEE properties due to the hydrogen-bond (H-bond) interactions among the inherent hydroxyl (OH) groups of the naphthol units. The H-bond interactions of PFN copolymer effectively restrict the molecular rotations and experimental variables (such as increasing solution concentration, introducing non-solvent water to solution, cooling and applying shearing forces during solvent evaporation stage etc.) effective in promoting the H-bond interactions result in the emission enhancement. Second, the fluorescent PFN was blended with poly(vinyl pyrrolidone) (PVR) through facile hydrogen-bond (H-bond) interactions. By the effective H-bond interactions between the OH groups of PFN and the carbonyl functions of PVR. The molecular rotations of PFN can be effectively locked by large amounts of carbonyl groups in PVR. With the efficient H-bond interactions, the PFN/PVR blend with the low content (2.33 wt%) of fluorescent PFN component actually has a high quantum efficiency of 0.93, comparatively higher than other blends containing higher fluorescent PFN. Third, novel vinyl polymer PTP with pendant AIE-effective tetraphenylthiophene (TP) group was prepared through radical polymerization. The resultant PTP polymer exhibits two discernible emission bands corresponding to monomer and aggregate emissions, respectively. The relative monomer to aggregate emission intensity of the PTP polymer in either the solution or the solid state depends strongly on the extent of aggregations. Increasing solution concentration results in the increasing extent of aggregation and the increasing aggregate/monomer emission ratio and also, the large emission enhancement due to the AIEE effect. Finally, the TP-derived ammonium (TP-NH3+) cations are complexed with poly(sodium vinylsulfonate) (PSV) polyanion to generate ionic PSV-TP(x/y) systems with long-range electrostatic interactions between the cationic ammonium of TP-NH3+ and the polyanion of PSV. The fluorophoric TP units are associated with each other to form large aggregate domains stabilized by the long-range interactions. Introduction of water into dilute solution of PSV-TP in THF resulted in self-aggregated nanoparticles and the accompanied emission enhancement due to AIEE effect. Introduction of excess PSV polyanions promoted the self-aggregation of the TP fluorophores and resulted in the fluorescence enhancement. Nevertheless, addition of NaCl electrolytes causes the dissociations of the TP aggregates and the corresponding emission reduction. By controlling the additive, the blended PSV-TP film containing excess PSV has a high quantum yield of ΦF = 0.83. In addition, the ionic PSV-TP complex film possesses high spectral stability without spectral variations after annealing at a high temperature of 270 oC.
Huang, Po-Chiao, i 黃柏喬. "Use of cyclodextrin to impose rotational restriction of luminogens with aggregation-induced emission property". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/t7rr7x.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
103
In Chapter 1, Because restricted molecular rotation is the main mechanism responsible for the aggregation-induced emission (AIE), a Jeffamine-included polyrotaxane (JCD) was therefore used in this study as rigid template to impose effective rotational restriction on the AIE-active luminogen of 1,2-bis(2,4-dihydroxybenzylidene)hydrazine (CN4OH). Besides rigidifying the flexible Jeffamine chain, the β-cyclodextrin (β-CD) rings of JCD also provided hydroxyl (OH) groups to hydrogen bond to the OHs of CN4OH, furnishing emissive CN4OH/JCD(x/y) (x/y: molar ratio between CN4OH and JCD) blends with emission efficiency higher than the pure CN4OH itself. Dependent on the composition of the blends, CN4OHs in the blends are arrayed differently to experience varied levels of rotational restriction and thus emit with an intensity correlated with molecular arrangement of the CN4OHs in the blends. The relationship between molecular arrangement, restricted molecular rotation and AIE-oriented emission behavior is the focus of this study. In Chapter 2, 3,4-diphenyl-2,5-bis(4-styryl)thiophene(TP2S)with AEE property showed 2,5-diphenylethene arms emission and tetraphenylthiophene (TP) center emission. β-CD were used as host molecule to encapsulate TP2S and showed an enhanced center emission and a decreased arm emission. Due to the rotational restriction, the TP2S/CD(x/y) (x/y: molar ratio between TP2S and β-CD)complex with emission intensity higher than the pure TP2S. In order to hinder TP2S slip out from β-CD, polymeric PS was used as template to grip the encapsulated TP2Ss through the π-π interactions of the aromatic phenyl rings in TP2S and in PS.When bind to PS, TP2S/CD/PS blends with higher emission intensity than the TP2S/CD complex.
Chowdhury, Aniket. "Vinylanthracene and Triphenylamine Based Luminescent Molecular Systems : From Aggregation-Induced Emission to Explosive Detection". Thesis, 2016. http://etd.iisc.ac.in/handle/2005/2968.
Pełny tekst źródłaChowdhury, Aniket. "Vinylanthracene and Triphenylamine Based Luminescent Molecular Systems : From Aggregation-Induced Emission to Explosive Detection". Thesis, 2016. http://etd.iisc.ernet.in/handle/2005/2968.
Pełny tekst źródłaChou, Tsu-Yu, i 周子喻. "Photophysical Properties of Thermally Activated Delay Fluorescence and Aggregation Induced Emission Organic Light Emitted Devices". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/48rchh.
Pełny tekst źródłaZhan, Fu-Kai, i 詹富凱. "The Effects of Alkyl Chain Length and Aggregation-Induced Emission Chromophore on Organic Self-Assembled Nanomaterials". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/36986890510788709767.
Pełny tekst źródła國立交通大學
材料科學與工程學系所
104
Recently, research of molecules behavior gradually matured, further controlling strength or weakness of molecular interaction, which is the origin of self assembly materials. The first part in my study, we discussed the effect of changing alkyl chain length on naphthalene diimide (NDI) to dipeptide self assembly. We chose methylamine、ethylamine、n-propylamine、n-butylamine and n-octylamine to be the aliphatic chain length on naphthalene diimide, connecting tyrosine and phenylalanine as peptide sequence to improve the value of application. In addition, we discovered different physical properties by chaning alkyl chain length. Carbon chains length affected critical gelation pH. As the length was decreased, the critical pH value changed from higher to lower. Minimum gelation concentration (MGC) increased with the chain decrease of carbon length. Sol-gel transition temperature and storage modulus (G’) on rheology increased as carbon chains increasing. In photo-luminescence (PL), fluorescence intensity decreased with increasing concentration and happened red shift. This demonstrated aggregation-caused quenching (ACQ) properties. In the second part, we synthesized biofunctional peptid sequence conjugated with tetraphenylethene (TPE) to produce aggregation-induced emission (AIE). We selected DGEA and RGD as biological sequence. 1 wt% TPE-GDGEA could’t form hydrogel but formed hydrogel at 3 wt% under acidic environment. 1 wt% TPE-FDGEA formed hydrogel under acdic environment and hydrogel at 3 wt% was formed under neutral environment. 3 wt% TPE-FDGEA has the hightest on sol-gel transition temperature and rheology. The structure of 3 wt% TPE-GDGEA hydrogel present naroribbons while TPE-GDGEA hydrogels under and all concentraitons including TPE-FDGEA were nanofibers. For biological experiments, 3 wt% TPE-FDGEA was better than TPE-GDGEA, because 3 wt%TPE-FDGEA could form hydrogel under netural environment. In order to investigate the difference between RGD and RGE, we also synthesized TPE-FRGD and TPE-FRGE. The both 1 wt% TPE-FRGD and 1 wt% TPE-FRGE formed hydrogel under acidic environment, while TPE-FRGD on sol-gel transition temperature and rheology was higher than TPE-FRGE and their structure present nanofibers.In addition, water fraction experiment indicated the both TPE-FRGD and TPE-FRGE displayed the AIE properties. On biological experiments, the both could enter into cells and performed fluorescence. In the future, the two TPE derivatives develop a prospective and novel materals with applying in the field of health and medicine.
Sudhakar, Pagidi. "Rational Design Facile Synthesis of Boryl Anilines : Intriguing Aggregation Induced Emission and External Stimuli Responsive Properties". Thesis, 2015. http://etd.iisc.ac.in/handle/2005/3884.
Pełny tekst źródłaSudhakar, Pagidi. "Rational Design Facile Synthesis of Boryl Anilines : Intriguing Aggregation Induced Emission and External Stimuli Responsive Properties". Thesis, 2015. http://etd.iisc.ernet.in/2005/3884.
Pełny tekst źródłaPing-FengHsu i 許秉豐. "A novel pyrene-Schiff base fluorescent ‘turn on’ sensor toward Zn2+ and Al3+ with aggregation-induced emission enhancement". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/uebdm5.
Pełny tekst źródła國立成功大學
化學工程學系
104
A novel fluorescent sensor PySb comprising of pyrene moiety as the fluorophore, benzene ring as the spacer, and 2-(hydroxymethyl)propane-1,3-diol as the ionophore was synthesized. PySb itself exhibited weak fluorescence due to photoinduced electron transfer (PET). It can serve as a highly selective and sensitive fluorescent ‘turn on’ sensor toward (a) Zn2+ in ethanol solution (λem = 470 nm) and (b) Al3+ in DMSO solution (λem = 458 nm). The complexes of PySb-Zn2+ and PySb-Al3+ were further supported by 1H NMR spectra. The 1:2 stoichiometry between PySb and Zn2+ was obtained from Job plot. Excellent detection limit toward Zn2+ (2.39×10-8 M) was derived from titration experiment. Similarly, the binding constant toward Zn2+ was estimated as 2×109 M-1 based on titration experiment. PySb-Zn2+ complex in DMF solution showed aggregation-induced emission enhancement with increasing content of ethanol (0-99%). It could be utilized as a fluorescent sensor in a wide range of pH (3-11). Green emission of PySb (λem = 515 nm) was observed when pH was higher than 12 due to intramolecular charge transfer (ICT).
Fu, Jin-Yuan, i 富靖元. "Fluorescent Light-up Probe with Aggregation Induced Emission for β-galactosidase Sensing and its application in living cells". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/me98a5.
Pełny tekst źródła國立交通大學
應用化學系碩博士班
107
TPE-gal for detecting β-galactosidase. β-galactosidase is a crucial biomarkerused to identify malignant tumorsand also associated with cell senescence.Compared to a normal ovarian cell, β-galactosidase in primary ovarian cancers cell is much higher. Therefore, the probe TPE-galconsists of tetraphenylethylene as a chromophore and two galactose groups as anenzyme-responsive moiety for β-galactosidase. Furthermore, two galactose moieties can greatly increase the solubility of the probe in water and prevent aggregation and emission. When β-galactosidase is detected, two galactosesin the probe was cut off to release a lower water-soluble chromophore, tetraphenylethylene, and causeaggregation induced emission. The fluorescent probe TPE-gal has shown high selectivity for detecting β-galactosidase and excellent biocompatibility to investigate endogenous β-galactosidase in the ovarian cancer cell, SKOV-3.
Chan, Han-Chieh, i 詹涵絜. "Syntheses of Tetraphenylethene Bridged Biscalix[4]arene Derivatives and Studies of Their Organogel Properties and Aggregation Induced Emission". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/723kf5.
Pełny tekst źródła國立交通大學
應用化學系碩博士班
108
In this thesis, we designed and synthesized tetraphenylethene bridged biscalix[4]arene derivatives (E)-30, (Z)-30, (E)-31 and (Z)-31 by click reaction. Control compounds (E)-34 and (Z)-34 were also synthesized for comparison. We have previously reported a serendipitous discovery that triazole bridged biscalix[4]arenes form organogels in certain conditions. These compounds were tested and we found that only compound (E)-30 was able to form gel with fluorescent in certain solvents. The gelation properties and self-assembly morphologies of compound (E)-30 was further examined by SEM, Variable-temperature 1H-NMR, IR spectroscopy and SEM to gain insight into the possible packing model. In addition, because these derivatives incorporated with tetraphenylethene scaffold, we also investigated their aggregation induced emission behavior. We revealed that different water fraction was required to initiate the AIE effect of all compounds. At the same time, we observed that all compounds have a slight blue shift when the fraction of water increases. The morphologies of the aggregated compounds were also examined by SEM.
Lai, Chung-Tin, i 賴俊廷. "Effect of molecular structure on the aggregation-induced emission properties of organic and polymeric materials containing tetraphenylthiophene or triphenylpyridine moiety". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/69101888517969686629.
Pełny tekst źródła國立中山大學
材料與光電科學學系研究所
100
About half a century ago, Főrster and Kasper discovered that traditional organic chromophore such as pyrene was weakened with an increase in its solution concentration. It was soon recognized that this was a general phenomenon for many aromatic compounds. This concentration-quenching effect was found to be caused by the formation of sandwich-shaped (disc-like) excimers and exciplexes aided by the collisional interactions between the aromatic molecules in the excited and ground states. In 2001, Tang’group discovered such a system, in which luminogen aggregation played a constructive, instead of a destructive, role in the light-emitting process: a series of silole molecules were found to be non-luminescent in the solution state but emissive in the aggregated state. They coined the term ‘‘aggregation-induced emission’’ (AIE) or “AIE enhancement” (AIEE) for this novel phenomenon which originated from the restricted intramolecular rotation (RIR) inherent from the chemical structures of the luminescent materials. To verify the effect of molecular structure on the AIE properties of organic and polymeric materials, four approaches were attempted in this research. (I) Aggregation-Induced Emission in Tetraphenylthiophene-Derived Organic Molecules and Vinyl Polymer Organic molecules of tetraphenylthiophene (TP) and the derived model compound of TP-Qu and vinyl polymer of PS-Qu with the pendant group of TP-Qu were prepared and characterized to identify their photoluminescent responses toward the effect of AIE. During aggregate formation, the corresponding TP solutions greatly gained the emission intensity. In contrast, TP-Qu and PS-Qu in isolated or aggregated states emitted strongly with nearly the same emission intensity. RIR is the key factor deciding the AIE effect in different states. With four small phenyl rotors around the central thiophene stator, the RIR of the TP molecules in dilute solution is low but increases upon aggregate formations. In contrast, the bulky C-2 quinoline rotor of the TP-Qu molecule enhances the RIR in isolated state. With the inherent TP-Qu pendant groups, the emissive behavior of vinyl polymer PS-Qu is similar to the TP-Qu molecule. (II) Aggregation-Induced Emission Enhancement of Diblock Copolymer Containing Tetraphenylthiophene-Quinoline Pendant Fluorphores by Selective Solvent Pairs In this study, diblock copolymer of PSQu-PBS containing 25 mol% of fluorescent PSQu segments was synthesized and its aggregation-induced emission enhancement (AIEE) behavior was characterized and compared to PSQu homopolymer with 100 mol% of fluorescent units. With fewer (25 %) fluorescent units, solutions of diblock PSQu-PBS copolymer actually have higher (or comparable) emission intensities than the homopolymer PSQu solutions. Solutions of PSQu-PBS in THF/H2O of varied compositions emit essentially with the same intensity but in contrast, emissions of PSQu-PBS in THF/hexane increase with the increasing hexane content. Copolymer micelles formed in THF/hexane mixtures are supposed to have higher extent of aggregation, leading to more pronounced AIEE effect than micelles formed in THF/H2O. (III) Tetraphenylthiophene-Functionalized Poly(N-isopropylacrylamide): Probing LCST with Aggregation-Induced Emission A hydrophobic TP center with novel AIE property was chemically linked to two poly(N-isopropylacrylamide) (PNIPAM) chains to obtain thermoresponsive polymers to study the relationships between the lower critical solution transitions (LCSTs) and the AIE-operative fluorenscence emission. Three ethynyl-terminated PNIPAMs with different molecular weights were synthesized via controlled atom transfer radical polymerization (ATRP) using ethynyl-functionalized initiator. The PNIPAMs were then coupled with diazide-funtionalized TP (TPN3) via click reaction to obtain the desired TP-embedded polymers of Px (x = 1, 2, and 3). All three polymers show AIE-property from their solution fluorescence behavior in THF/hexane mixtures. In the aqueous solution, the TP-center served as a fluorogenic probe that reveals the LCSTs of polymers and its relation to the degree of TP labeling in terms of polymer concentration. The thermoresponsiveness of Px was demonstrated by the complete emission quench when heated at temperatures above LCST. Dissociation of the TP aggregates above LCST is responsible for the emission quench. (IV) Influence of Molecular Weight on the Aggregation-Induced Emission of Vinyl Polymers Containing the Fluorescent 2,4,6-Triphenylpyridine Pendant Groups Molecular weight effect on the AIEE property of vinyl polymers containing fluorescent 2,4,6-triphenylpyridine (TPP) pendant groups was evaluated in the fourth topic. The high and low Mw vinyl polymers of PDMPS–L and –H were prepared through Click chemistry between azide–TPP derivative and acetylene–functionalized polystyrenes. Solutions of the low Mw PDMPS–L exhibited the normal AIEE effect with continuous emission gains with increasing extent of aggregation upon nonsolvent inclusion. On the contrast, the high Mw PDMPS–H solutions emitted with constant intensity on all solutions with different extent of aggregation. Despite the varied solution behavior, the solid PDMPS-L and –H films are all strong deep-blue emitter with high quantum yields of 84 and 82.5%, respectively. The emission behavior was explained by the conformational difference between the PDMPS–L and –H chains, which were approached by computer simulation in this topic.