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Peneau, Justine. "Dynamique dispositive et structure temporelle de la co-conception : une analyse du travail de design en agence". Electronic Thesis or Diss., Institut polytechnique de Paris, 2023. http://www.theses.fr/2023IPPAT002.
Pełny tekst źródłaThis thesis takes place within a digital agency that implements design methods that allow its clients to be involved in the design. This field allows me to observe co-design situations that bring together an agency and a client organization, situations that have been little studied in the literature. Our immersion and our commitment as a designer allowed us to experience the temporalities of agency work and to come back in particular to what the vocabulary and the so-called “sprint” methods imply in relation to time in design. It is a multidisciplinary thesis that brings together the sciences of information and communication and design. They make it possible to jointly analyze communication and design situations as well as the supports that support them.It therefore seemed important to us to understand the co-design situation less through the concept of space (which tends to predominate) than through that of time.Our hypothesis is that we can consider the activity of design as the organization of temporal formats which have effects on participation but also which presuppose models of design. The thesis pays attention to the dynamics of emergence. These latter involve another relationship to time based on moving inter-relations. This hypothesis thus more particularly led us to study the “sprint” method as a temporal format but also to be attentive to what emerges at the heart of these “formatted” situations and to the way in which design expertise ties and unties temporalities. Finally, we observe that the design situation opens up a transitional space, a “benevolent device”, where time is “dynamically suspended” precisely to allow links to be forged between the plurality of temporalities that crosses the project between past, present and future
Simon, Nathalie. "Agence de design : construction de croyances et de pratiques autour de l'observation et la création". Paris 7, 2006. http://www.theses.fr/2006PA070074.
Pełny tekst źródłaLearning how to carry a glance and to adopt an ethnological posture to elucidate our contemporary, to understand the others and oneself Here,a design agency is the ground for an ethnological approach, that of an ergonomist carrying out a participating observation; and who open to ethnology and ethnomethodology, is giving an attempt to identify the obvious concepts, the beliefs and the practices of its members. What are the directions that the individuals belonging to a multiple culture give to their daily activities? IP is a particular agency of design and innovation. The belief on which it is based is that of an alliance between social sciences and desjgn. During nearly four years, designers and an ergonomist have worked in this agency, on projects of products innovation. Those were the observable supports of the beliefs and of the practices of the members and they illustrate here their evolutions in order to answer to the alliance between observation and creation. The work of the individuals went from an activity partitioned between different professions, which fail to recognize each other well, with that of a team in which the obvious concepts, the common practices, the exchanges and the divisions constituted themselves, towards a co-construction of the method of the agency, towards an identity construction work. The research deals with the real process of creation work, of the relations of co-operation and the mobilization of the practices and subjectivities to go from the concept of profession to the one of individuals, an essential posture to consider an improvement of the multidisciplinary collaborative process and the integration of the professions in design
Lafaye, Rachel. "Design et expériences dans la formation continue en ligne : la création de MOOC en agence". Thesis, Bourgogne Franche-Comté, 2019. http://www.theses.fr/2019UBFCH032.
Pełny tekst źródłaIn the domain of training, new technologies have come and gone but have not provided real answers to the problems of online continuing training. And yet, with each introduction of a new technology, research is conducted into the learners, the theoretical aspects of course design and the characterization of the devices created. What is lacking seems to be an analysis of design in the field; such an analysis would make it possible to imagine positive developments and to implement research results in hands-on practice.In the era of MOOC and their use by companies, how are online continuing training courses designed ? In the specific context of the creation MOOC by an agency, we set out to describe the design of online training from two perspectives : that of the design activity and that of the experiences that the training brings about.For this research I had the advantage of being at the same time a PhD student and a salaried employee of an agency specialized in online training and was thus able to collect « scenes of life » as both participant and observer and these were used to establish a model of design, according to the Theory of Activity.For the study of the experiences, four MOOC projects of the agency served as case studies. After a presentation of the design choices specific to each project and the quantitative results obtained, the representations resulting from the experiences are analyzed based on the semi-directive interviews that we carried out.Finally, this work proposes a descriptive method of design and joint analysis of design and experiences. As part of the observed field, new perspectives related to the design of online training were raised concerning the mediation of knowledge, its strategic and evolutionary dimensions
Prévet, Antoine. "Incitations et contractualisation dans le secteur public". Thesis, Paris 1, 2018. http://www.theses.fr/2018PA01E014.
Pełny tekst źródłaThis thesis focuses on the structural specificities of the public sector and how they impact incentives and performance. It uses the microeconomic tools of contract theory and econometric analysis. Among these characteristics, special attention is paid to monitoring, information management and budget constraints by applying a theoretical lens, that allows to provide new insights into the incentive systems in place in the public sector. The first chapter contributes to the debate on transparency in the public sector by considering one of its major features, i.e. a limited budget. This issue is studied as an information design problem and employ a principal-agent model with moral hazard to show that if the principal has to choose between total transparency and total opacity, then transparency is more likely to be optimal when tasks are least valuable and budgets are lowest. The second chapter aims at capturing a new theoretical explanation for the widespread intuition that more bureaucracy could lead to less effort and quality despite improved control. To that end, the idea of “the extra mile” is introduced in a classic principal-agent model with moral hazard. Bureaucratic management is characterized by the use of procedures, defined as the association of codification and verification. A procedure allows for more accurate verification of the agent’s action, but is socially inefficient. In the third chapter, using both theory and regression analysis, we propose a new explanation for price differences in the French water industry based on organizational arguments
Ozel, Derya. "La promesse du durable : situations de conception architecturale en Inde". Thesis, Paris 10, 2017. http://www.theses.fr/2017PA100014.
Pełny tekst źródłaThis work explores the making of sustainability in the field of architecture in India. It is based on two ethnographical studies made in 2011 and 2012, in an architectural studio in the city of Ahmedabad (in the State of Gujarat) and in an consultancy firm in the city of Bombay (in the State of Maharashtra). The arrival of labels on the real estate and construction markets makes it possible to date the idea of sustainability in architectural design and rekindle a typical local debate. The controversy more specifically concerns the implementation of LEED certifications of American origin. This “Western” and procedural sustainability, which serves economic and marketing logics, does not represent, according to the architects, the “authentic” one. But then, India is said to be, par excellence, the country of sustainability: just look the lifestyles, Indian culture, or of course, the “traditional” and “vernacular” architecture. Beyond the rhetoric between tradition and modernity, the ethnographic investigation follows the small details of architectural projects in the making and shows the similarities between the studio and the consultancy firm. The fate of sustainability is related, in one way or another, to ideas of commitment and conviction. The ideal of sustainability is not lying so much on a certainty (which still more or less depends on the actors), but on the daily life and on the practices that tend to give it life and the most substance possible
Valdes, Cristopher Ballinas. "The politics of agency design : politics and the forging of autonomous agencies in Mexico". Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539939.
Pełny tekst źródłaGu, Ning. "Dynamic Designs of Virtual Worlds Using Generative Design Agents". Thesis, The University of Sydney, 2006. http://hdl.handle.net/2123/984.
Pełny tekst źródłaGu, Ning. "Dynamic Designs of Virtual Worlds Using Generative Design Agents". Architecture, 2006. http://hdl.handle.net/2123/984.
Pełny tekst źródłaThis research aims at developing a different kind of virtual world that is dynamically designed and implemented as needed. Currently, most virtual world designs are considered static. Similar to the physical world, these worlds are pre-defined prior to their use. The resultant environments serve certain purposes but do not take into consideration possible changes to the purposes during their use, changes which often occur when the occupants interact with the environments and with each other. Virtual worlds as networked environments can be flexibly configured and programmed. This flexibility makes it possible to consider virtual world designs in terms of dynamics and autonomy, reflecting the changing needs of different moments. To achieve dynamic designs of virtual worlds, this study applies a computational approach using rational design agents. A Generative Design Agent (GDA) model is developed that specifies computational processes for reasoning and designing in virtual worlds. The GDAs serve as personal design agents to the virtual world occupants. Design formalisms for virtual worlds are also addressed. The design component of a GDA is supported by the application of a generative design grammar. On one hand, generative design grammars serve as the generative force to be applied by the GDAs for virtual world design automation. On the other hand, each grammar defines coherent stylistic characterisations shared by the virtual world designs it generates. The technical outcomes of the research consist of the GDA model and a generative design grammar framework. The framework provides guidelines and strategies to designers for developing generative design grammars that produce different design languages for virtual worlds, rather than predefine every detail of all possible virtual world designs. GDAs monitor the virtual worlds and the various activities that occur in the worlds, interpret the occupants’ needs in the virtual worlds and the state of the worlds based on these observations, hypothesise design goals in order to satisfy these needs, and finally apply generative design grammars to provide virtual world designs for the moment, or initiate other actions in the worlds, according to the current design goals, on behalf of the occupants. The development of the GDA model and the generative design grammar framework provides new perspectives for understanding and developing virtual worlds. The GDA model challenges the conventional way that virtual worlds are designed and implemented, and this leads to dynamic designs of virtual worlds. The generative design grammar framework provides a computational approach to formally defining design languages for virtual worlds.
Carlsson, Nicole. "Vulnerable data interactions — augmenting agency". Thesis, Malmö universitet, Fakulteten för kultur och samhälle (KS), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-23309.
Pełny tekst źródłaGasque, Travis M. "Design agency: Dissecting the layers of tabletop role-playing game campaign design". Thesis, Georgia Institute of Technology, 2016. http://hdl.handle.net/1853/55055.
Pełny tekst źródłaTostenson, Thomas Daniel. "Design for starting a chaplain agency". Theological Research Exchange Network (TREN), 2007. http://www.tren.com/search.cfm?p067-0008.
Pełny tekst źródłaMatthews, Michael Thomas. "Learner Agency and Responsibility in Educational Technology". BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/6532.
Pełny tekst źródłaLala, Divesh. "The design and implementation of dynamic interactive agents in virtual basketball". 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199434.
Pełny tekst źródłaQually, Byron Alexander. "Design and democracy : transformative agency within indigenous structure". Thesis, Open University, 2018. http://oro.open.ac.uk/55017/.
Pełny tekst źródłaMontinari, Natalia. "Incentive Design with Reciprocal Agents". Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421623.
Pełny tekst źródłaAbstract [In Italian] Incentive Design with Reciprocal Agents La presente tesi analizza la definizione ottimale di incentivi in presenza di agenti economici caratterizzati da other regarding preferences, e in particolare preferenze per la reciprocità. Recentemente, una crescente letteratura in ambito economico analizza i fattori in grado di influenzare l’efficacia dei sistemi di incentivazione sia a livello individuale che di gruppo (es. organizzazioni, comunità, etc). Accanto a una corposa letteratura che documenta il corretto funzionamento degli incentivi, es. Gibbons, (1997), Lazear (2000), infatti, un filone di studi in crescita riporta evidenze di casi in cui gli incentivi sembrano non essere efficaci, (Angrist and Lavy, 2009) o addirittura controproducenti, determinando il crowding out delle motivazioni intrinseche (si veda, tra gli altri Ariely et al., 2009; Frey e Oberholzer-Gee, 1997; Gneezy e Rustichini, 2000). In particolare, non è ovvio che incentivi disegnati partendo dall’assunzione che gli agenti economici siano motivati esclusivamente da self-interest siano ugualmente efficaci nei casi in cui gli individui presentano c.d. other regarding preferences, Gintis et al. (2005), Bowles (2009). Nei casi in cui risultino sostituti delle motivazioni, gli incentivi economici saranno inefficaci o addirittura controproducenti. In queste situazioni osserveremo il c.d crowding out delle motivazioni intrinseche o un over-justification effect, Bénabou and Tirole, (2003). Ci sono però anche dei casi in cui gli incentivi rinforzano le motivazioni intrinseche, manifestando un effetto complementare, come documentato da Bowles (2009), Galbiati and Vetrova (2009). La tesi è composta da quattro capitoli, facenti riferimento a quattro articoli autonomi. Il primo capitolo è un modello teorico che spiega la presenza di lavoro straordinario non (adeguatamente) ricompensato documentato in molte organizzazioni e in quasi tutti i paesi industrializzati. Quando i lavoratori sono motivati da reciprocità sia verso il proprio datore di lavoro (o in generale verso un superiore gerarchico) sia verso i colleghi, un manager interessato a massimizzare il profitto troverà conveniente offrire ai lavoratori uno schema di compensazione competitivo che induca i dipendenti a fare lavoro straordinario senza essere (totalmente) compensati. I lavoratori saranno motivati da reciprocità negativa verso i colleghi e vorranno impedire loro di segnalarsi agli occhi del datore di lavoro. Il secondo capitolo utilizza la metodologia sperimentale per analizzare la presenza di effetti di spillover tra due contesti decisionali diversi ma in cui i soggetti partecipano simultaneamente. Un contesto decisionale è sempre identico in ognuno dei tre trattamenti, e presenta i caratteri del dilemma sociale. Il secondo contesto decisionale varia in ogni trattamento e fa riferimento a diverse tipologie di sistemi di incentivi: incentivi di team, tornei e piece rate. Spesso, infatti, si è simultaneamente coinvolti in più interazioni con diverse persone. In ambito lavorativo, per esempio, il lavoratore compete con alcuni colleghi (es. per avanzamenti di carriera) e deve collaborare con altri. Mentre alcuni ambiti di interazioni possono essere oggetto di diverse forme di incentivazione, esiste una dimensione in cui la cooperazione volontaria è necessaria ma non può essere imposta. Il lavoro evidenzia che quando i soggetti sono contemporaneamente esposti a tornei e contesti di dilemma sociale, il livello medio di cooperazione volontaria sarà minore del caso in cui i soggetti siano esposti a un incentivo di team. Questa evidenza suggerisce di incorporare anche considerazioni legate agli effetti di spillover nel valutare l’efficacia dei sistemi di incentivazione. Il terzo capitolo analizza sperimentalmente la rilevanza di informazioni (inutili) su pari (es. colleghi in un’organizzazione) in presenza di schemi di compensazione di tipo individuale. In molti contesti organizzativi, infatti, i lavoratori possono osservarsi reciprocamente non è chiaro quale sia il livello ottimale di comunicazione e trasparenza interna che debba essere promosso da parte dei manager. I risultati di questo lavoro dimostrano che avere informazioni su soggetti simili aumenta la probabilità di rivedere le proprie scelte in maniera ottimale ma questo effetto è rilevante solo se l’informazione veicolata informa il soggetto di essere in una situazione peggiore del suo pari. I soggetti, pertanto, manifestano una forma di attenzione selettiva alle informazioni sugli altri. Infine, l’ultimo capitolo presenta un’analisi empirica sull’efficacia di sistemi di incentivi alternativi finalizzati ad aumentare la percentuale di raccolta differenziata. Lo studio utilizza dati sulla produzione annuale di rifiuti di 95 comuni nella provincia di Treviso dal 1999 al 2008. In seguito a un provvedimento legislativo regionale i paesi della provincia sono stati assegnati a tre consorzi che hanno perseguito strategie differenti per la gestione dei rifiuti urbani. In particolare, mentre quasi tutti i comuni hanno un programma di raccolta dei rifiuti porta a porta (DtD) solo un sottogruppo di comuni ha adottato una metodologia di pagamento che lega la produzione di rifiuti all’ammontare effettivo pagato, c.d. Pay as you throw (PAYT). La nostra analisi dimostra che sia la DtT che la PAYT aumentano sensibilmente la percentuale di raccolta differenziata, la tariffa ha un effetto che cresce significativamente nel tempo. Inoltre, sebbene sia documentato un significativo spostamento dei rifiuti dai comuni che adottano la PAYT a quelli limitrofi che non hanno la DtD, a livello di municipalità questo effetto è trascurabile dal momento che l’effetto netto associato all’adozione della PAYT è positivo.
Tewari, Manish. "SECURITY DESIGN THAT ADDRESSES AGENCY CONFLICTS AND INFORMATION ASYMMETRY". Doctoral diss., University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3441.
Pełny tekst źródłaPh.D.
Department of Finance
Business Administration
Business Administration PhD
Qvarfordt, Johan, i Johan Ronner. "Agency Centric Design and Engaging Game Art in VR". Thesis, Blekinge Tekniska Högskola, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-14660.
Pełny tekst źródłaFöhr, Stephanie. "Beyond human (self-) care : Exploring fermentation as a practice of caring with humans, non-humans and the planet Earth". Thesis, Linnéuniversitetet, Institutionen för design (DE), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-96699.
Pełny tekst źródłaAly, Safwan Krishnamurti Ramesh. "A framework for interaction and task decomposition for objects emulating agency behavior /". Pittsburgh, Pa. : Carnegie Mellon University, 2000. http://code.arc.cmu.edu/lab/upload/aly%5Fphd%5Fthesis.0.pdf.
Pełny tekst źródłaPonder, Brenda. "A case study examining ethics training within an award-winning federal agency". Thesis, University of Phoenix, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3731430.
Pełny tekst źródłaThe ethics training program of the United States Army Corps of Engineers (USACE), Alaska District, a recipient of the Office of Government Ethics (OGE) 2010 Education and Communication Award, was studied to determine if the training fostered employee awareness of unethical situations within the workplace. The study fills a gap in scholarly literature in that never before had a peer-review study been done to examine how ethics training fosters awareness within an award-winning federal agency. The method and design used for collecting the data was the qualitative exploratory case study. Seven data sources were analyzed using NVivo 10 ® software and Microsoft Excel and conclusions drawn by use of data source triangulation. Two primary data sources used were responses from two sets of interview questions: one set with 15 employees and another set with two ethics training coordinators. The other five sources of data evidence used were the OGE 2009 Education and Commission Awards Announcement, the OGE 2009 Education and Communication Award Application Form submitted by Alaska District to OGE, samples of the Ethics Monthly Treats, and comments made by the interviewees on the 2-minute ethics video (Secret Ethics Man), and brownbag lunches. The framework for this study was Gagne’s theoretical instructional design model. The three emerging themes were: ethics information was distributed frequently, innovative delivery methods, and content of ethics instruction. The results of the study indicate that the design, delivery, and components of the training program may have been effective in fostering employee awareness of unethical situations within the workplace.
Berger, James R. "Federal agencies and design/build contracting". Thesis, Springfield, Virginia: Available from National Technical Information Service, 1991. http://hdl.handle.net/10945/28212.
Pełny tekst źródłaRedij, Tejashree. "Rational Design of Anti-diabetic Agents". Thesis, University of the Sciences in Philadelphia, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13861629.
Pełny tekst źródłaThe Glucagon-like peptide 1 receptor (GLP-1R) belongs to the pharmaceutically important Class B family of G-protein coupled receptors (GPCRs) and its incretin peptide ligand GLP-1 analogs are adopted drugs for the treatment of type 2 diabetes (T2D). Despite remarkable anti-diabetic effects, Glucagon Like Peptide-1 (GLP-1) peptide-based drugs are limited by the need of injection or high cost oral formulation. On the other hand, developing non-peptide small molecule drugs targeting GLP-1R remains elusive likely due to the large nature of the orthosteric binding site on GLP-1R. A promising approach is to develop small molecule agonistic positive allosteric modulators (ago-PAMs) or positive allosteric modulators (PAMs) of GLP-1R by targeting the potential allosteric sites in the transmembrane (TM) domain of human GLP-1R.
As the first step of taking this approach, we constructed a three-dimensional structure model of the TM domain of human GLP-1R using homology modeling and conformational sampling techniques. Next, a potential allosteric binding site on the TM domain was predicted computationally. In silico screening of drug-like compounds against this predicted allosteric site has identified nine compounds as potential GLP-1R agonists. The independent agonistic activity of two compounds was subsequently confirmed using cyclic adenosine monophosphate (cAMP) response element (CRE)-based luciferase reporting system. One compound was also shown to stimulate insulin secretion through in vitro assay. In addition, this compound synergized with GLP-1 to activate human GLP-1R.
In 2017, the crystal structures of GLP-1R in its active state (PDB ID: 5VAI) became available. Hence, we have performed another round of in silico screening employing this structure. First, the potential ligand binding sites in 5VAI were identified using computational tools and in silico screening procedure as described above was carried out again. A new small 8 molecule with low molecular weight and logP was identified. In vitro studies of this compound confirmed that it acts as the ago-Positive Allosteric Modulator (PAM) of GLP-1R that improves GLP-1's affinity and efficacy towards GLP-1R. When used in combination with GLP-1, this compound improves insulin secretion than using GLP-1 alone. Site specific mutagenesis studies confirmed its binding site as predicted in the TM domain of GLP-1R.
Finally, this ago-PAM molecule was further optimized to improve its potency and specificity towards GLP-1R using structure-based optimization strategy and medicinal synthesis. The newly designed compound, whose molecular weight was less than the parental compound, was found to act as the PAM of GLP-1R and showed improvement in the specificity than the parental compound. Thus, this new compound could be further exploited in the drug development for T2D treatment.
These results demonstrated that allosteric regulation exists in GLP-1R and can be exploited for developing small molecule agonists. The success of this work will help pave the way for small molecule drug discovery targeting other Class B GPCRs through allosteric regulations.
Segovia, Laserna Rosario. "Novel antimicrobial peptides for therapeutic applications: design, synthesis, characterization, and evaluation of their biological and biophysical activity". Doctoral thesis, Universitat de Barcelona, 2022. http://hdl.handle.net/10803/673907.
Pełny tekst źródłaDesprés de dècades d'excessiu ús d'antibiòtics en la medicina humana, l'agricultura i la indústria ramadera, els bacteris multiresistents (resistents a molts o tots els antibiòtics convencionals) s'han convertit en un important problema de salut pública de primer ordre a escala mundial. En aquest sentit, és de gran importància el disseny de nous antimicrobians, segurs i efectius, especialment contra els bacteris Gram-negatius. Les polimixines són lipopèptids antimicrobians, altament actius i selectius contra bacteris Gram-negatius que es van descobrir l'any 1947, però el seu ús es va abandonar a la dècada dels 70 a causa de la seva nefro- i neurotoxicitat. En les últimes dècades, les polimixines han estat rescatades com a teràpia d'últim recurs als hospitals a causa de la crisi dels antibiòtics. Per aquest motiu, durant aquesta tesi es van dissenyar, sintetitzar i caracteritzar 31 nous compostos basats en polimixina. A més, es va avaluar la seva activitat biològica i el seu mecanisme d'acció mitjançant diversos assajos microbiològics i biofísics. Finalment, es van seleccionar dos compostos com a candidats més prometedors per al seu posterior desenvolupament. Aquests presentaven una activitat in vitro i in vivo comparable a la mostrada per la polimixina natural i uns efectes nefrotòxics in vivo excepcionalment baixos. D'altra banda, es va estudiar la capacitat de formar porus a les membranes bacterianes per part del BP100. El BP100 és un pèptid antimicrobià d'11 aminoàcids derivat de cecropina A i melitina. Mitjançant l'estudi d'una sèrie d'anàlegs de BP100 amb diferents longituds que anaven de 4 a 24 aminoàcids, es va poder determinar el seu potencial mecanisme d'acció, que consisteix en un mecanisme de “dynamic carpet” on el BP100 s'insereix dinàmicament a la membrana, pertorbant la bicapa, augmentant la permeabilitat d’aquesta de manera que finalment es produeix la mort cel·lular.
Hromasová, Lucie. "Analýza firemní identity společnosti NIOSPORT agency,a.s". Master's thesis, Vysoká škola ekonomická v Praze, 2012. http://www.nusl.cz/ntk/nusl-142093.
Pełny tekst źródłaGibbons, Sophie Elizabeth. "The Effects of Non Profit Agency Website Donation Button Design on Aid Agency Trust and Donation Compliance". Thesis, University of Canterbury. Psychology, 2010. http://hdl.handle.net/10092/3672.
Pełny tekst źródłaHolmes, Robert D. "A multi-commodity network design for the Defense Logistics Agency". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1994. http://handle.dtic.mil/100.2/ADA283499.
Pełny tekst źródłaRahimi, Bafrani Raena. "The Agency of Earth on the Site of the Design". Thesis, Virginia Tech, 2021. http://hdl.handle.net/10919/104163.
Pełny tekst źródłaMaster of Landscape Architecture
Earth as one of the existing materials of a site constantly affects the process of the design. This study focuses on describing and improving the use and understanding this material shared by the disciplines of architecture and landscape architecture. As landscape architecture has been incredibly important to civilization throughout history, this project looks at different ways that earth has affected design through important periods of history, from Greeks to modern design. Considering many examples in which designers have worked with the current land, there are other cases across cultures where people have changed earth. Thinking about different designs, there are many possible answers to this thesis question from using existing hills to making mountains. This design is an artificial mound as a monument to indigenous people and it is about reviving the missed parts of the earth in order to empower the ground, rethinking the whole earth and protecting it, turning it into an important earthwork that is not only about something for people but also making it into something which in invisible situations it cannot be. Based on the tradition of Native American mound builders, part of this thesis is to affirm the value of diversity and equality in the US, through creating a gathering space for all people that pays special attention to indigenous culture.
Kimber, Kay D. "Technoliteracy, teacher agency and design: Shaping a digital learning culture". Thesis, Queensland University of Technology, 2002. https://eprints.qut.edu.au/36677/1/36677_Digitised%20Thesis.pdf.
Pełny tekst źródłaZrehen, Stéphane. "Elements of brain design for autonomous agents /". [S.l.] : [s.n.], 1995. http://library.epfl.ch/theses/?nr=1373.
Pełny tekst źródłaOkamoto, Masayuki. "Design and applications of learning conversational agents". 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148780.
Pełny tekst źródłaArnold, Stephen John. "The design of agents against alzheimer's disease". Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536076.
Pełny tekst źródłaKhristova, Tetiana. "Computer-aided design of novel antithrombotic agents". Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-01018545.
Pełny tekst źródłaDe, Jager Josephus Jacobus. "Design and synthesis of novel antimalarial agents". Thesis, Stellenbosh : Stellenbosh University, 2014. http://hdl.handle.net/10019.1/96071.
Pełny tekst źródłaENGLISH ABSTRACT: Malaria is a pestilent disease associated with massive socioeconomic burden of sub-Saharan Africa. This disease is caused by a blood infection of the single cellular parasite of the Plasmodium genus. Two enzymes of this parasite have been identified to be essential to the survival of this parasite, notably Spermidine Synthase and Protein Farnesyltransferase. The goal of this dissertation was to search for and synthesise novel inhibitors of these two enzymes with a strong focus towards understanding their structure/activity relationships. To achieve the first goal, molecular modelling was employed. An in-depth discussion is presented to describe the underlying principles relevant to this branch of computational chemistry. This ensures that the experiments using these methods are set-up correctly and results are interpreted within context. Two virtual high-throughput screens were then performed using prepared crystallographic structures of Spermidine Synthase. The first was pharmacophore based method and the second based on LibDock. The database used, containing 7.1 million compounds, was filtered using a custom developed tool prior to screening. Finally, CDOCKER was then used to investigate the activity of potential hit compounds. Spermidine Synthase has a natural affinity for adenosine and this trait was exploited by derivatising analogues to synthesise potential inhibitors of the enzyme. This was to be achieved by the incorporation of both electrophilic and nucleophilic moieties at selected positions, including the use of a high yielding Mitsunobu reaction. A number of additional residues were then synthesised and joined to the adenosine which were proposed to increase the active site occupancy and increase affinity to the enzyme. For the second enzyme targeted for inhibition, Protein Farnesyltransferase, indole was used as a starting scaffold to synthesise potential hits de novo. It was aimed to derivatise the indole at the Nʹ and 3ʹ positions. The crystal structure of one of the intermediates was published. Furthermore, a synthetic sequence which culminated in a palladium catalysed Suzuki coupling was performed.
AFRIKAANSE OPSOMMING: Malaria is ‘n peslike siekte wat geassosieer word met beduinde sosio-ekonomiese implikasies vir sub-Sahara Afrika. Die siekte word veroorsaak deur ‘n bloed infeksie van die enkel sellulêre parasiet van die Plasmodium genus. Twee ensieme, naamlik Spermidien Sintetase en Protein Farnesieltransferase, is geïdentifiseer om noodsaaklik te wees vir die oorlewing van die parasiet. Die doelwit van hierdie verhandeling is die soektog en sintese van oorspronklike inhibeerders van hierdie twee ensieme met ‘n sterk fokus daarop om struktuur/aktiwiteit interaksies te verstaan. Om die eerste doelwit te bereik is molekulêre modellering toegepas. ‘n Indiepte ondersoek word voorgestel om die onderliggende beginsels relevant tot hierdie tak van berekenkundige chemie te beskryf. Dit verseker dat eksperimente wat op hierdie tegnieke berus korrek opgestel word en dat die resultate binne konteks geïnterpreteer word. Twee virtuele hoë-deurset skerms was deurgevoer op voorbereide kristallografiese strukture van Spermidien Sintetase. Die eerste het berus op ‘n pharmakoforiese metode en die tweede op LibDock. ‘n Self-ontwikkelde sagteware gereedskap stuk is gebruik om a databasis van 7.1 miljoen verbindings te filtreer voor dit gebruik is in hoë-deurset skerms. Uiteindelik is CDOCKER gebruik om die potensiele aktiwiteit van “treffer” verbindings te beraam. Spermidien syntetase het ‘n natuurlike affiniteit vir adenosien en hierdie eienskap is benut deur analoeë af te lei na potensiële inhibeerders teen die ensiem. Dit is bewerkstellig deur die insluiting van beide elektrofiliese asook nukleifielese funksionele groepe op gekose posisies. Dit het die gebruik van ‘n hoë opbrengs Mitsunobu reaksie ingesluit. ‘n Aantal ander addisionele residueë is toe gesintetiseer en geheg aan die afgeleide adenosien om die ensiem setel te vul en sodoende die affinitieit te verhoog. Vir die tweede ensiem wat geteiken is vir inhibisie, Protein Farnesieltransferase, is indool benuttig as ‘n begin steier te dien om potensiële treffers de novo te sintetiseer. Dit is geteiken om die indool af te lei op die Nʹ en 3ʹ posisies en die kristal struktuur van een van hierdie tussengangers is gepubliseer. Verder is ‘n sintetiese weg, wat uitgeloop het op ‘n palladium gekataliseerde Suzuki koppeling, uitgevoer.
Williams, Jarrod C. "Design and Synthesis of Superresolution Imaging Agents". Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1342887517.
Pełny tekst źródłaZhang, Weihe. "Design and Synthesis of Potential Anticancer Agents". Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1288896777.
Pełny tekst źródłaKhan, Nasim B. "Design and synthesis of potential antimicrobial agents". Thesis, Aston University, 2007. http://publications.aston.ac.uk/11064/.
Pełny tekst źródłaSikdar, Soumick. "Design and synthesis of potential antimicrobial agents". Thesis, Aston University, 2010. http://publications.aston.ac.uk/15794/.
Pełny tekst źródłaTan, Jinlong. "Design and Synthesis of Novel Antibacterial Agents". Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/25809.
Pełny tekst źródłaManna, Ester. "Essays on incentive design for motivated agents". Doctoral thesis, Universita degli studi di Salerno, 2013. http://hdl.handle.net/10556/1017.
Pełny tekst źródłaI develop an overview on the impact of intrinsic motivation on the individu- als’ choice in several economic environments. I start by considering a public good problem in which individuals can be intrinsically motivated. Even if the intrinsic motivation has a positive impact on the levels of public good contributed, it seems difficult to achieve the socially optimal level of contribution. When intrinsic mo- tivations alone are not sufficient to supply the socially optimal level, a principal’s intervention is necessary. The intervention usually takes the form of monetary in- centives. These incentives may conflict with individuals’ intrinsic motivation. I analyze the interaction between intrinsic motivation and monetary incentives in or- der to understand how people respond to incentives. In this sense, this work is related to the literature on psychological incentives in organizations (B´enabou and Tirole, 2003, 2006; Gneezy and Rustichini, 2000a, 2000b). A key prediction of this literature is that motivation is effective in stimulating effort even in the absence of a monetary compensation. This overview is also related to the literature on the self-selection of motivated employees in different sectors (see for instance Besley and Ghatak, 2005, and Prendergast, 2007). This literature suggests that the public sector pays lower incentives to attract motivated employees. This review exam- ines implications regarding the design of optimal incentives and public policy, the selection of motivated agents and its interaction with monetary rewards.I develop a multi-agent model where the individuals are the agents who are asked to contribute to the public good. The individuals may be interested not only in their own utility but also in the well-being of the others. Namely, individuals may or may not be intrinsically motivated. Whether they are motivated or not is their private information. I investigate the possibility of implementing a mecha- nism compatible with individual incentives that simultaneously results in efficient decisions, the voluntary participation of the individuals, and the feasibility of the budget. Under asymmetric information on the individuals’ intrinsic motivation, the principal has to offer different transfers to different agents in order to attain sepa- ration of types. The transfers are made as a function of their degree of motivation. Both individuals will be taxed but motivated individuals pay lower taxes than un- motivated individuals. This is because the principal pays an information rent to motivated individuals in order to elicit higher levels of effort. Monetary incentives are necessary to compensate motivated individuals in order to increase the levels of contribution.I study whether the presence of motivated teachers benefits public and private schools in a competitive environment. The quality is influenced by the effort exerted by the teachers. Teachers’ motivation may have a positive impact on the levels of effort and, then, on the quality. The effect of motivation strictly depends on the degree of differentiation of the programmes offered by the two schools. When both schools offer similar programmes, the Nash equilibrium is the one in which both schools hire motivated teachers. This is because teachers’ motivation plays an important role in the students’ choice between the two school. In contrast, when the two schools offer significantly different programmes, the Nash equilibrium is the one in which both schools hire selfish teachers. The increase in the students’ utility due to the higher quality provided by the motivated teachers is more than offset by the reduction in the profits earned by the two schools. [edited by author]
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Mosley, Sylvester L. "Base-modified carbocyclic nucleosides as medicinal agents". Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/27041.
Pełny tekst źródłaVictor, Sundar K. "Negotiation Between Distributed Agents in a Concurrent Engineering System". Digital WPI, 1999. https://digitalcommons.wpi.edu/etd-theses/1083.
Pełny tekst źródłaBerker, Ilan. "Conflicts and Negotiations in Single Function Agent Based Design Systems". Digital WPI, 1999. https://digitalcommons.wpi.edu/etd-theses/1075.
Pełny tekst źródłaClifton, Heather A. "Computational antiviral drug design". Muncie, Ind. : Ball State University, 2009. http://cardinalscholar.bsu.edu/645.
Pełny tekst źródłaCook, Duncan. "Art, agency and eco-politics : rethinking urban subjects and environment(s)". Thesis, Royal College of Art, 2014. http://researchonline.rca.ac.uk/1645/.
Pełny tekst źródłaLa, Boissonniere François. "An approach to design autonomous agents within ModSAF". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/Mq44911.pdf.
Pełny tekst źródłaJones, William Alexander. "Design and synthesis of intracellular MR contrast agents". Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497879.
Pełny tekst źródłaMugoyela, Veronica Kapesa. "The design and synthesis of novel trypanocidal agents". Thesis, University of Sunderland, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314809.
Pełny tekst źródłaWilson, Karen. "Agents, affectivity and aesthetics in user-interface design". Thesis, Abertay University, 2007. https://rke.abertay.ac.uk/en/studentTheses/632067a9-4c26-4823-86f8-45f041a259ec.
Pełny tekst źródłaCarroll, Gabriel D. (Gabriel Drew). "Approaches to mechanism design with boundedly rational agents". Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72829.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references.
This dissertation ties together three papers on mechanism design with boundedly rational agents. These papers explore theoretically whether, and to what extent, limitations on agents' ability to strategically misrepresent their preferences can help a mechanism designer achieve outcomes that she could not achieve with perfectly rational agents. The first chapter investigates whether local incentive constraints are sufficient to logically imply full incentive-compatibility, in a variety of mechanism design settings. This can be motivated by a boundedly rational model in which agents cannot contemplate all possible misrepresentations, but can consider those that are close to their true preferences. This chapter offers a unified approach that covers both continuous and discrete type spaces, showing that in many commonly studied cases, local incentive-compatibility (suitably defined) implies full incentive-compatibility. The second chapter advances the methodology of looking quantitatively at incentives for strategic behavior, motivated by the premise that agents will be truthful if the incentive to be strategic is small enough. This chapter defines a mechanism's susceptibility to manipulation as the maximum amount of expected utility any agent can ever gain from strategic misrepresntation. This measure of susceptibility is then applied to anonymous voting rules. One set of results estimates the susceptibility of specific voting rules; an important finding is that several voting systems previously identified as resistant to manipulation are actually more susceptible than simple plurality rule, by the measure proposed here. A second set of results gives asymptotic lower bounds on susceptibility for any possible voting rule, under various combinations of efficiency, regularity, and informational conditions. These results illustrate how one can quantitatively explore the tradeoffs between susceptibility and other properties of the voting rule. The third chapter carries the methodology of the second chapter to a market environment: unit-demand, private-value double auction markets. This chapter quantitatively studies the tradeoff between inefficiency and susceptibility to manipulation, among all possible mechanisms for such markets. The main result approximately locates the possibility frontier, pinning it down within a factor that is logarithmic in the size of the market.
by Gabriel D. Carroll.
Ph.D.
Bivigou, Koumba Achille Mayelle. "Design, synthesis and characterization of novel raft agents". Thesis, Stellenbosch : University of Stellenbosch, 2005. http://hdl.handle.net/10019.1/2992.
Pełny tekst źródłaThis thesis begins with the description of the preparation of thirteen dithioesters (of the form Z- (C=S)-S-R) which were characterized via Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (NMR) and ultraviolet spectroscopy (UV). The dithioesters were then used as reversible addition-fragmentation chain transfer (RAFT) mediating agents in the bulk polymerization of styrene, in order to observe differences in the kinetic behaviour of the polymerizations and, as a result, the efficiencies of the dithioesters in mediating the polymerizations.