Gotowa bibliografia na temat „After 1763”

Peter Forsskål (1732–1763) was the naturalist on the Royal Danish Expedition to Arabia (1761–1767), a particularly rich example of the eighteenth century era of scientific exploration and a quintessential project of the Enlightenment. Forsskål is noteworthy for his early writings in philosophy and politics and for his outstanding contributions to the botanical and zoological knowledge of the Middle East, specifically Egypt and the Arabian Peninsula, principally Yemen. His biological work stands out for the large number of species identified, its attention to detail, the expansiveness of his descriptions, his knowledge and use of Arabic and his early ideas on plant geography. Forsskål's research in the marine biology of the Red Sea was also pioneering. His publications and collections represent the single greatest contribution to the knowledge of the natural history of the Middle East in the eighteenth century and are still valued by scholars today. His skill in retaining local terminology in Arabic and his respect for the contributions of local inhabitants to this work are also worth noting. When he died of malaria in 1763 in Yemen, the eighteenth-century world of natural science lost a promising and adventurous scientist.

In a report on the state of Poland in 1766 the papal nuncio, A. E. Visconti, observed that the new king, Stanisław August Poniatowski, possessed ‘a burning desire to reform the whole country in one day – if only he could – and the entire nation, in order to bring it up to the level of other, more advanced nations’. The interregnum after the death of Augustus III in October 1763 and Poniatowski's election in September 1764 had inaugurated the most determined campaign for reform within the Polish-Lithuanian Commonwealth since the Union of Lublin of 1569. By 1763–4 there was little that did not need to be reformed. The accumulation of privilege by the szlachta, the nobility, had attained such dimensions that both the monarchy and the Sejm, the parliament, were almost powerless to govern. The most obvious expression of the impotence of the state and of the refusal of the nobility to submit to the discipline of any centralized authority was, of course, the liberum veto, the use of which, real or threatened, had consigned the majority of the Sejmy of Augustus II (1697–1733) and of Augustus III (1733–63) to nullity. Yet the veto's successful, widespread application was only possible because of a rough equilibrium of political strength between Poland's various magnate factions.After Augustus Ill's death, Russian military backing enabled the so-called ‘Family’, the party led by Michael Czartoryski (1696–1775) and his brother, August (1697–1782), to break through the stalemate. At the Convocation Sejm of 7 May to 23 June 1764, the Czartoryskis pushed through a series of unprecedented reforms aimed at conferring on the monarchy and the Sejm a degree of real authority over the country at large.

Around 1970 Tjeder suggested two changes to the nomenclature of the Ascalaphidae regarding the names Libelloides and libelluloides. To avoid future confusion, we augment Tjeder’s work by analyzing the nomenclatural status of all taxa related to these names—specifically Libelloides Schäffer, 1763 and Libelloides coccajus ([Denis et Schiffermüller], 1775), Ascalaphidae, and Palpares libelluloides (Linnaeus, 1764), Myrmeleontidae. After a short historical preamble, we treat the three taxa in chronological order of description. Additional information is reported in four Addenda, followed by a list of synonymies. Our conclusions are as follows: 1. Schäffer’s Das Zwiefalter– oder Afterjüngferchen (1763) is consistent with the Principle of Binomial Nomenclature, thus the names Libelloides and Libellula spuria, therein created, are available [ICZN Code Article 11.4.1.]. 2. Libellula spuria Schäffer, 1763, is a senior synonym of Papilio coccajus [Denis et Schiffermüller], 1775; however, the older name Libellula spuria Schäffer, 1763, is a nomen oblitum with respect to the younger name Papilio coccajus [Denis et Schiffermüller], 1775, which therefore must be considered a nomen protectum [ICNZ Code Article 23.9.2: both Articles 23.9.2.1 and 23.9.2.2 apply]. 3. The name Hemerobius libelloides Linnaeus, 1764, is the correct original spelling [ICNZ Code Article 32.5.1 does not apply], but the subsequent spelling Myrmeleon libelluloides Linnaeus, 1767, even if an unjustified emendation [ICZN Code Article 33.2.1 and 33.2.3], is in prevailing usage and consequently: i) it is deemed to be a justified emendation, and ii) it is attributed to its original author and date [ICZN Code Article 33.2.3.1]. 4. Myrmeleon libelluloides Fuesslin, 1775, being a mere misidentification of the name Myrmeleon libelluloides (Linnaeus, 1764), is unavailable name [ICZN Code Article 49]. 5. Schäffer (1763) is not the author of the name Ascalaphus libelluloides: the authorship must be attributed to van der Weele with the date of description 5th January 1909. 6. Libellula turcica Petiver & Empson, 1767, in Ábrahám (2012), is an unavailable name. 7. The original spelling Myrmeleon kolywanense Laxmann, 1770, is the correct original spelling [ICNZ Code Article 32.5.1 does not apply], but the subsequent spelling Ascalaphus kolyvanensis Rambur, 1842, even if an unjustified emendation [ICZN Code Article 33.2.1 and 33.2.3], is in prevailing usage and consequently: i) it is deemed to be a justified emendation, and ii) it is attributed to its original author and date [ICZN Code Article 33.2.3.1]. 8. Fuesslin’s Verzeichniss der ihm bekannten schweizerischen Insekten (1775) was published between 24th February (date in the second part of the Preface [Vorrede]) and 12th May 1775 (Wyttenbach, 1775), so the date of publication is 12th May 1775 [ICZN Code Article 21.3].

There are two hypotheses explaining a fulminant outcome after hepatitis B virus (HBV) infection, both of which may be applicable at the same time: (i) basal core promoter (BCP) mutations increase viral replication, allowing rapid spread of the virus through the liver, and (ii) pre-core (pre-C) mutations abrogating hepatitis B e antigen (HBeAg) synthesis remove its tolerogenic effect, leading to a vigorous immune response. This study investigated the effect of these mutations on virus replication efficiency and HBeAg production. Substitutions A1762T/G1764A and T1753C, C1766T and T1768A in the BCP region, and G1896A and G1899A in the pre-C region, were examined either alone or in combination, using a common genetic background. Huh7 cells were transfected with these constructs and real-time PCR was used to quantify released virion-associated and intracellular HBV DNA, pregenomic RNA and pre-C mRNA. In addition, culture supernatants were tested for hepatitis B surface antigen (HBsAg) and HBeAg. The double BCP mutation (A1762T/G1764A) and the pre-C mutations (G1896A, G1899A), either alone or in combination, had no appreciable effect on the replication capacity of the virus. In contrast, clones with mutations at positions 1766/1768, 1762/1764/1766 and 1753/1762/1764 exhibited increased-replication phenotypes. HBeAg was undetectable in all cultures transfected with constructs bearing the G1896A stop-codon mutation, as expected. In contrast, constructs with additional mutations in the BCP region had appreciably lower levels of HBeAg expression than the wild type. Thus, core promoter mutations other than those at 1762/1764 appear to upregulate viral DNA replication and, at the same time, greatly reduce HBeAg production.

Introduction. The financial factor had its full effect during the next major pan-European conflict – the Seven Years’ War (1756–1763). The Seven Years’ War can be considered as the “zero” World War of the 18th century. Its fighting took place in all parts of the world and oceans known then. All the major Christian powers of that time were drawn into it. In terms of the level of militarization, this war surpassed all previous coalition wars. The financial crisis caused by the Seven Years’ War was also very different from the previous ones and had a pan-European effect. The purpose of the article is to study the causes of the financial crisis of 1763. Materials and Methods. Comparative-historical, chronological and genealogical research methods were used, the principles of objectivity and historicism were observed. Results. The crisis was led by the confidence of some banks and financial firms in a win-win business related to the supply of military operations. Discussion and Conclusion. After Frederick II began defacing coins, according to the Copernicus – Gresham law, degraded money is forced out of circulation by full-weight ones, so the German princes, who were neighbors of Prussia, were forced to voluntarily lower the silver content in their coins. There was nothing left but to start the debasing process. This leads to the financial crisis of 1763.

Background: Covalent Bruton's tyrosine kinase (BTK) inhibitors (cBTKi) have transformed treatment landscape of chronic lymphocytic leukemia (CLL). These inhibitors bind to C481 residue in the kinase domain of BTK. This is also the site for the most common mutations rendering cells resistant to cBTKi. To circumvent this limitation of the cBTKi, non-covalent BTKi (ncBTKi) such as pirtobrutinib have been developed. Recently, non-C481 BTK mutations have been reported in patients with CLL at the time of disease progression during pirtobrutinib treatment. These observations underscore the need for ncBTKi that can target C481 as well as non-C481 mutations of BTK. AS-1763 is a potent, highly selective, orally available, and ncBTKi, equipotent against both wild-type and C481S-mutated BTK when tested in biochemical assays. In vivo, AS-1763 demonstrated significant antitumor effects in OCI-LY10 tumor xenograft models harboring wild-type or C481S mutant BTK (Kawahata et al. J Med Chem 64:14129, 2021). Study Design and Methods: In the present project, first we used cell free assay systems to evaluate selectivity and potency of AS-1763 by a kinome-wide profiling and inhibitory effect of AS-1763 in enzyme assays using recombinant mutant BTK. Second, we examined dose- and time-dependent inhibition of mutant BTK that is expressed in HEK293 cell line. Third, we tested biological, biochemical, and molecular impact of AS-1763 in primary CLL cells. Fourth, we determined sensitivity of CLL cells to AS-1763 when combined with other targeted agents. Results: AS-1763 showed a highly selective profile for BTK in a panel of 291 kinase assays with >260-fold selectivity except 3 Tec family kinases (BMX, ITK, and TEC). We have generated a total of 17 recombinant BTK mutant proteins (C481, T474, L528 variants and other BTK mutants; Table 1) reported in the literature or predicted by single nucleotide change in the codon, and established assay methods to measure inhibitory potency of BTKi for those BTK mutants (Table 1). AS-1763 showed potent inhibitory activities for those BTK mutants while inhibitory potencies of other cBTKi and ncBTKi were diminished against some BTK mutants such as T474 and/or L528 mutations. AS-1763 exhibited dose-dependent and slow-off rate inhibitions of BTK autophosphorylation (pY223) in HEK293 cells transfected with various BTK mutants. Furthermore, the observed inhibitory effects of AS-1763 on the BTK autophosphorylation (pY223) in HEK293 cells were continued up to 24 h after washing out of AS-1763. In primary CLL samples, AS-1763, pirtobrutinib or ibrutinib induced a modest apoptosis. AS-1763 effectively inhibited the BCR signaling pathway in a dose dependent manner as evidenced by downregulation of pY223-BTK expression which was also observed in cBTKi and ncBTKi relapsed/refractory CLL samples. In vitro incubations with AS-1763 inhibited CLL cell spontaneous migration, decreased CCL3/CCL4 levels in culture supernatant and was accompanied with the inhibition of intracellular calcium release and B-cell activation, as measured by surface CD86 expression. Besides, AS-1763 incubation for 24 hours was shown to modulate the expression of BCL-2 family proteins with the downregulation of MCL-1 and BCL-xl. Interestingly, in vitro treatment of CLL patient samples with AS-1763 demonstrated a notable elevation in cellular ROS and mitochondrial superoxide levels starting at 1 µM, concurrently impacting SOD1 expression in CLL patient samples. Evaluation of drug interaction models utilizing Compusyn and Synergy Finder applications predominantly indicated additive effects between AS-1763 with BCL-2 inhibitor, venetoclax as well as p53 activator APR-246. Consistent with this data, AS-1763 and venetoclax combinations showed high-rates of apoptosis in samples that were relapsed/refractory to cBTKi and ncBTKi. Conclusions: AS-1763 is a selective ncBTKi that inhibits both wild-type and mutant BTKs listed in Table 1. In CLL cells, AS-1763 was effective in inhibiting BCR pathway signaling and sensitized cells to other agents such as venetoclax. Based on these encouraging data we have initiated a clinical trial to test AS-1763 in patients with CLL and other B cell malignancies who have failed or are intolerant to at least two prior lines of systemic therapy, including cBTKi (NCT05602363 Clinical Trials.gov).

Leonty (born as Luka Stepanovich Zelensky in 1726, died in 1807), priestmonk from the Monastery of the Exaltation of the Holy Cross in Poltava, undertook the pilgrimage to the Holy Land in 1763 1766. His itinerary included Egypt, the Sinai Peninsula and Palestine. After his trip to Levant he arrived to Istanbul where he became the chaplain of the church attached to the Russian Embassy. Since that time, the Ottoman capital became his home for the rest of his days. He only left Istanbul for Russia twice in 1771 1775 and 1787 1793. In 1767 Leonty was honoured the title of archimandrite. In 1788 the cleric resigned from the pastoral service and in his advanced age painstakingly worked on his multivolume autobiography. The first three volumes of Leontys memoirs are dedicated to the detailed and vivid description of his pilgrimage to the renowned holy places of Egypt and Palestine. Leontys memoirs are a quaint mixture of various facts, inner dialogues and personal observations of the local inhabitants, their occupations and lifestyles he encountered, including established beliefs, manners and customs. The aim of the present article is to survey particular facets of Leontys narrative as a valuable source for scholars dealing with Ottoman history and to examine his ambivalent attitude towards Islam and its followers living in the ArabOttoman world.Иеромонах полтавского Крестовоздвиженского монастыря (the Monastery of the Exaltation of the Holy Cross in Poltava) Леония (в миру Лука Степанович Зеленский) (1726 1807) совершил хождение в Святую землю в 1763 1766 гг. Его маршрут включал посещение мест поклонения в Египте, включая Синай, и Палестине. По завершении паломничества он остался на службе в церкви при российском посольстве в Стамбуле, где прожил до конца жизни. В России ему довелось побывать в России только дважды в 1771 1775 гг. и 1787 1793 гг. В 1767 г. Леоний был возведен в сан архимандрита, а в 1788 г. он оставил место церковного настоятеля и на закате жизни всецело отдался литературному творчеству. Его перу принадлежит тринадцатитомные мемуары, первые три тома которой посвящены описанию его путешествия к святым местам Египта и Палестины. Сочинение Леонтия лишено композиционного единства и представляет собой причудливую смесь разнообразных фактов, бытовых и психологических зарисовок, метких наблюдений и внутренних диалогов, в которых исследователи найдут много важного и полезного. Одним из сюжетов, привлекательных для историковвостоковедов, является тема отношения российского богомольца к исламу и его последователям представителям арабоосманского мира.