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Tamulevičienė, Daiva. "Responsibility centres in the system of controlling". Buhalterinės apskaitos teorija ir praktika, nr 15 (10.04.2014): 126–40. http://dx.doi.org/10.15388/batp.2014.15.11.
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Controlling is the new concept of modern management based on planning, control, accountability, and coordinate and consultative activity. One of the essential conditions of the installation of controlling is decentralization of management. The information in the system of controlling is accumulated and analysed not at the level of the whole company, but at the separate segments called as responsibility centres. The aim of the article is to examine the significance of the responsibility centres in the system of controlling and to propose the methodology of responsibility centres establishment and evaluation of theirs activity.
The responsibility centre might be a division of the company or some segment of activity or geography. Depending on what responsibility centres would be created in the company, that would have an effect on efficiency of the controlling system‘s behaviour. Although there exist many different features of the classification of responsibility centres, it is appropriate, in the companies‘ practice, to make responsibility centres in accordance with the fields of activity: cost, revenue, profit and investment centres. It is appropriate to make and install the system of responsibility centres and internal reporting by suggested sequence of four stages: organizational structure diagnostics; establishment of responsibility centres; establishment of internal reporting by the responsibility centres and establishment of the system of evaluation of the responsibility centres activity and motivation of employees.
The purpose of responsibility centres and installation of responsibility accounting in the controlling system is to ensure an efficient behaviour of the organization and the maximization of its results both in short-term and in long-term perspective. The only way to reach the purpose is by evaluating the input of each responsibility centre‘s to the overall result. The controlling service‘s task is to solve all the problems that occur in practice when establishing the responsibility centres and the reporting of responsibility centres and to select such indicators of the evaluation of each centre that would reflect the connection of activity of corresponding centre‘s employees and their achievements to the goals of organization in the best possible way.
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Strooband, Karel FB, Rebecca M. Stanley, Anthony D. Okely i Rachel A. Jones. "Support to Enhance Level of Implementation in Physical Activity Interventions: An Observational Study". Australasian Journal of Early Childhood 43, nr 1 (marzec 2018): 25–33. http://dx.doi.org/10.23965/ajec.43.1.03.
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THIS ARTICLE AIMS TO DESCRIBE the level of implementation (LOI) of the Jump Start study, and examine the relationship between LOI changes and the support types provided to early childhood education and care (ECEC) centres. Direct observations were conducted in 21 ECEC centres at six months and 12 months after the start of the intervention. Each centre's LOI percentage was calculated and classified into high, medium or low implementers using objective criteria. Support strategies were determined by LOI at first observation. Pearson correlations between the support types and LOI were calculated using SPSS Statistics (version 23.0). In most cases (86%), ongoing support led to an increase in LOI, 17.5% on average. Phone calls were the only type of support significantly related to the positive LOI change (r = 0.532, p = 0.013). It was difficult to detect other effective support types due to the combined and small variance in support types provided to each centre.
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Juodraitis, Adolfas, i Odeta Šapelytė. "Paradoxicality of the activity of institutional education institutions: principles and opportunities". Social welfare : interdisciplinary approach 4, nr 1 (1.06.2014): 31–44. http://dx.doi.org/10.15388/sw.2014.28247.
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The article presents the problem of paradoxicality of the activity of juvenile institutional education (i.e., socialisation centres operating in Lithuania). Several important variables have not been considered in the interaction of the activities of the socialisation centre, simultaneously of pedagogical and other staff and learners, their families/foster parents, and this resulted in inconsistency of the implementation of the complex resocialisation process. The article calls for the scientific discussion, actualising essential principles of resocialisation observed in socialisation centres, grounded on empirical data of children’s subjective experience (N= 97) and assessment of specialists of the child socialisation centre (N=94).
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Thompson, RL, EV Bandera, VJ Burley, JE Cade, D. Forman, JL Freudenheim, D. Greenwood i in. "Reproducibility of systematic literature reviews on food, nutrition, physical activity and endometrial cancer". Public Health Nutrition 11, nr 10 (październik 2008): 1006–14. http://dx.doi.org/10.1017/s1368980007001334.
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AbstractObjectiveDespite the increasing dependence on systematic reviews to summarise the literature and to issue public health recommendations, the formal assessment of the reliability of conclusions emerging from systematic reviews has received little attention. The main goal of the present study was to evaluate whether two independent centres, in two continents, draw similar conclusions regarding the association of food, nutrition and physical activity and endometrial cancer, when provided with the same general instructions and with similar resources.DesignThe assessment of reproducibility concentrated on four main areas: (1) paper search and selection; (2) assignment of study design; (3) inclusion of ‘key’ papers; and (4) individual studies selected for meta-analysis and the summary risk estimate obtained.ResultsIn total 310 relevant papers were identified, 166 (54 %) were included by both centres. Of the remaining 144 papers, 72 (50 %) were retrieved in the searches of one centre and not the other (54 in centre A, 18 in centre B) and 72 were retrieved in both searches but regarded as relevant by only one of the centres (52 in centre A, 20 in centre B). Of papers included by both centres, 80 % were allocated the same study design. Agreement for inclusion of cohort-type and case–control studies was about 63 % compared with 50 % or less for ecological and case series studies. The agreement for inclusion of 138 ‘key’ papers was 87 %. Summary risk estimates from meta-analyses were similar.ConclusionsTransparency of process and explicit detailed procedures are necessary parts of a systematic review and crucial for the reader to interpret its findings.
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Davies, Ruth. "The social impact of activity centres". Australian Planner 41, nr 3 (styczeń 2004): 35–37. http://dx.doi.org/10.1080/07293682.2004.9982368.
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Wójcik, Dariusz, Vladimír Pažitka, Eric Knight i Phillip O’Neill. "Investment banking centres since the global financial crisis: New typology, ranking and trends". Environment and Planning A: Economy and Space 51, nr 3 (24.09.2018): 687–704. http://dx.doi.org/10.1177/0308518x18797702.
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Financial centres are central to contemporary capitalism, but research on their development has been impeded by methodological challenges related to data availability. This paper offers a new typology of financial centre activity. Based on the nationality of parent companies of financial service providers operating in a centre, and the nationalities of their customers, we distinguish between domestic, export, import and platform activities. Second, we compile a unique dataset of investment banking deals worldwide, which allows us to apply the new typology and introduce the first ever ranking of top financial centres based on the actual investment banking activity conducted in these centres. Our findings confirm the dominance of New York and London as global financial centres, with New York focused on domestic activities, and London on export and platform activities. Our data also show that, overall, investment banking activity has fallen dramatically since 2007, with 60% of the decline concentrated in New York, and a further 30% in Zurich, London, Frankfurt, Amsterdam and Edinburgh combined. As a result, the dominance of investment banking by New York and London has diminished, contributing to a trend that predates the crisis, explainable by the increasing shares of Asian centres, with Tokyo and Chinese cities in the lead.
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Graham, Dawn Fowler, Ian Graham i Michael J. MacLean. "Going to the Mall: A Leisure Activity of Urban Elderly People". Canadian Journal on Aging / La Revue canadienne du vieillissement 10, nr 4 (1991): 345–58. http://dx.doi.org/10.1017/s0714980800011375.
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RÉSUMÉLe propos de cet article est d'introduire, de définir et de tester un modèle théorique qui puisse expliquer la fréquentation par les personnes âgées des centres d'achats urbains, conçus comme des endroits d'échanges sociaux. Nous estimons que les personnes âgées vont dans les centres d'achats pour satisfaire leurs besoins de vie sociale et de loisirs. Nous créons le néologisme « mailler » pour aller au mail ou au centre d'achat. Nous émettons ensuite l'hypothèse qu'il existe des variables individuelles, c'est-à-dire de prédisposition et des variables environnementales, c'est-à-dire d'incitation, variables qui différencient les personnes âgées adeptes de ces activités de magasinage. En nous fondant sur l'analyse de données secondaires, tirées d'un échantillonnage de 300 personnes âgées montréalaises vivant à domicile, nous avons découvert que le magasinage, effectué dans trois centres d'achats de Montréal, constitue une activité pour plus de 67 pour cent des sujets de l'échantillon. Certaines variables sont à relier à cette activaté: variables de prédisposition telles que l'âge, le sexe, l'éducation et aussi le sentiment de solitude et variables incitatives comme l'architecture du centre d'achat et son ambiance. En nous fondant sur ces résultats, nous pensons que ce modèle nous aide à mieux comprendre les activités de loisirs des personnes âgées demeurant à domicile.
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Haftenberger, M., AJ Schuit, MJ Tormo, H. Boeing, N. Wareham, HB Bueno-de-Mesquita, M. Kumle i in. "Physical activity of subjects aged 50–64 years involved in the European Prospective Investigation into Cancer and Nutrition (EPIC)". Public Health Nutrition 5, nr 6b (grudzień 2002): 1163–77. http://dx.doi.org/10.1079/phn2002397.
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AbstractObjective:To describe physical activity of participants in the European Prospective Investigation into Cancer and Nutrition (EPIC).Design:A cross-sectional analysis of baseline data of a European prospective cohort study.Subjects:This analysis was restricted to participants in the age group 50–64 years, which was represented in all EPIC centres. It involved 236 386 participants from 25 centres in nine countries. In each EPIC centre, physical activity was assessed by standardised and validated questions. Frequency distribution of type of professional activity and participation in non-professional activities, and age-adjusted means, medians and percentiles of time dedicated to non-professional activities are presented for men and women from each centre.Results:Professional activity was most frequently classified as sedentary or standing in all centres. There was a wide variation regarding participation in different types of non-professional activities and time dedicated to these activities across EPIC centres. Over 80% of all EPIC participants engaged in walking, while less than 50% of the subjects participated in sport. Total time dedicated to recreational activities was highest among the Dutch participants and lowest among men from Malmö (Sweden) and women from Naples (Italy). In all centres, total time dedicated to recreational activity in the summer was higher than in the winter. Women from southern Europe spent the most time on housekeeping.Conclusions:There is a considerable variation of physical activity across EPIC centres. This variation was especially evident for recreational activities in both men and women.
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GOLOVCHENKO, Glib. "ANALYSIS OF MEDIA EDUCATION CENTRES’ ACTIVITY IN UKRAINE". Cherkasy University Bulletin: Pedagogical Sciences, nr 2 (2020): 118–25. http://dx.doi.org/10.31651/2524-2660-2020-2-118-125.
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Introduction. Currently the age of digital society requires its members to freely acquire new skills for the successful use of the possibilities of the new digital reality –media and information literacy. As a result, media education, which is recognized by UNESCO as a separate field of education, is becoming increasingly important. Ukraine has already some positive achie-?ements in the sphere of media education. Purpose. The paper is aimed at systematizing the experience gained by Ukraine through the prism of media education centers’ activity.Methods. A set of theoretical research methods was used to study the areas of Ukrainian media education: a review of the literature, selection and interpretation of results, their systematization and identification of prospects. Results. The activity of 3 recognized domestic centers of media education is described: the Institute of Social and Political Psychology, the Institute of Higher Education of the National Academy of Pedagogical Sciences of Ukraine and the Institute of Ecology of Mass Information. Generalization and systematization of their media educational activities made it possible to distinguish the following criteria: historical, methodological, prognostic. Thanks to their use, 2 new media educational centers were identified: the Academy of Press of Ukraine and the College of Press and Television in Mykolayiv. The history of their creation, peculiarities of development and introduction of scientific, educational and methodical maintenance are analyzed, the directions of their further activity are outlined. Originality of the paper lies in the analysis of media education trends in Ukraine through the activity of the acknowledged media education centres and the new ones. Conclusion. A study of the media educational activities of these centers led to the conclusion that they are all similar in their mission – media education. At the same time, they have unique features that are manifested in the practical implementation of media education. It is planned to investigate the peculiarities of media education activity that was totally conducted in the distant form due to COVID 19 pandemic.
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Dumbleker, Vinod. "Call Centres: A Customer Centric Business Activity". Paradigm 6, nr 2 (lipiec 2002): 107–21. http://dx.doi.org/10.1177/0971890720020209.
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Bristow, Gillian, Max Munday i Peter Gripaios. "Call Centre Growth and Location: Corporate Strategy and the Spatial Division of Labour". Environment and Planning A: Economy and Space 32, nr 3 (marzec 2000): 519–38. http://dx.doi.org/10.1068/a3265.
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The authors contribute to the developing literature on call centres by providing detailed empirical evidence on the spatial unevenness in the distribution of call centre activity. They argue that the driving forces of call centre growth, whether as the rationalisation of back-office functions or as entirely new entities, have been corporate strategy and the pursuit of low-cost competitive advantage. Thus, although technological developments at the heart of call centre operations render them relatively ‘footloose’ in locational terms, the search for specific characteristics makes certain regions (and parts of regions) more attractive than others. By using a sample database of call centres, the authors describe the characteristics of call centres in the United Kingdom in terms of size, sector, and spatial distribution. They then attempt to explain the determinants of call centre location at the county level through a multiple regression analysis. The results indicate that there is a propensity to site call centres close to existing concentrations of allied activity, with preferences for densely populated areas mediated by needs to maintain employee access and avoid staff turnover problems. This has important implications for the spatial division of labour, with call centre growth likely to reinforce existing spatial unevenness in employment in key service activities. The authors conclude by considering the implications of these findings for contemporary urban and regional development, as well as providing a number of suggestions for future research.
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Firliansyah, Eterna, Mirza Dikari Kusrini i Arzyana Sunkar. "Pemanfaatan dan Efektivitas Kegiatan Penangkaran Penyu di Bali bagi Konservasi Penyu". Journal of Tropical Biodiversity and Biotechnology 2, nr 1 (4.10.2017): 21. http://dx.doi.org/10.22146/jtbb.25690.
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Sea turtle has been widely consumed in Bali since the 1970s mostly for religious activities. After many international critics, various stakeholders (governments, NGOs, environmentalists and Balinese people) developed the so-called “turtle conservation centre” as means to conserve sea turtles. The purpose of this study is to assess the effectiveness of those conservation efforts by evaluating the conservation activities of each conservation centres. We visited five sea turtle conservation centres in Bali; all were named as captive breeding centres or farm. The captive breeding centre is misleading as there is no activity related to captive breeding, mostly hatchery. Some of the eggs were not even originated from Bali, and the centres were sometimes used as the source for sea turtle for religious purposes. Based on the scoring, only one centre is active in terms of conservation. Turtle conservation program in Bali should increase their in situ program, i.e. mapping and protecting the nesting habitat and conducting regular monitoring of nesting turtle.
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López Fernández, Jorge, Alejandro López-Valenciano, Xián Mayo, Elizabeth Horton, Ivan Clavel, Gary Liguori i Alfonso Jiménez. "Comparative analysis of reported physical activity from leisure centres’ members versus the general population in Spain". BMJ Open 11, nr 6 (czerwiec 2021): e043963. http://dx.doi.org/10.1136/bmjopen-2020-043963.
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Objectives(1) To describe the physical activity (PA) levels of the members of a Spanish leisure centre operator according to age and gender; (2) to describe the differences in the three PA levels between the members of a Spanish leisure centre operator and the general Spanish population considering the PA Eurobarometer data according to their gender and age and (3) to explore the intensity origin of the PA either in Spanish members of leisure centres or the Spanish population considering their gender.DesignDescriptive epidemiology study.ParticipantsData from 16 Spanish leisure centres (n=3627) and from the 2017 Eurobarometer 472 for Spain (n=1002) were used for this research.Primary and secondary outcomes measuresThe PA levels were analysed with the International Physical Activity Questionnaire short version, and respondents were grouped into physical inactivity (PIA), moderate-PA and high-PA. Moreover, gender (men or women) and age (18–29 years; 30–44 years; 45–59 years; 60–69 years; ≥70 years) were considered. Total metabolic equivalent (MET)-min/week, as well as total MET-min/week for walking intensity, moderate intensity and vigorous intensity were recorded.ResultsLeisure centres showed a lower prevalence of PIA and a higher prevalence of high-PA than the general population (p<0.05). Women displayed a higher prevalence of PIA and lower prevalence of high-PA than men (p<0.05). The prevalence of PIA increases with age while the prevalence of high-PA decreases.ConclusionLeisure centres engage most of their members in regular PA, including women and older adults, and these members also perform a higher number of MET in vigorous PA, than the general population.
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Liu, Chang, i Nigel Harwood. "Understandings of the Role of the One-to-One Writing Tutor in a U.K. University Writing Centre: Multiple Perspectives". Written Communication 39, nr 2 (28.02.2022): 228–75. http://dx.doi.org/10.1177/07410883211069057.
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This article presents findings from a study of a U.K. university writing centre regarding understandings of tutor roles, involving 33 Chinese international students, 11 writing tutors, and the centre director. The research used interviews and audio-recorded consultations as data to analyze and explore participants’ beliefs and understandings. The most common roles associated with tutors were proofreader, coach, commentator, counsellor, ally, and teacher. Mismatches were found in understandings of the proofreader role and counsellor role when comparing students’ views, tutors’ views, and the writing centre policy. Policy recommendations are made in light of the findings regarding how writing centres frame the tutor’s role and the function of writing consultations, in terms of (1) interrogating traditional conceptualizations of tutor role, (2) disseminating the centre’s aims to the student population and to the wider university, (3) expanding the centre’s activity across the university, and (4) strengthening tutor training and development.
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Renton, S. J., N. E. Lightfoot i M. A. Maar. "Physical activity promotion in call centres: employers' perspectives". Health Education Research 26, nr 6 (28.06.2011): 1050–59. http://dx.doi.org/10.1093/her/cyr055.
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GORĄCZKOWSKA, JADWIGA. "INFLUENCE OF INNOVATION CENTRES ON INNOVATION ACTIVITY IN INDUSTRY IN THE MAZOVIA PROVINCE". sj-economics scientific journal 24, nr 1 (30.06.2017): 318–29. http://dx.doi.org/10.58246/sjeconomics.v24i1.243.
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The article presents the influence of the innovation centres on regions innovation development based on Mazovia Province. The probit model is used to present how the innovation centres stimulate innovative activity in 951 industry companies from this region. The most important conclusions are:
1) innovation centres, especially technology parks, technology incubators stimulate innovative activity in a systematic way,2) centres stimulate cooperation too, but it is on low level.
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Chow, Amanda Froehlich, i Louise Humbert. "Physical Activity and Nutrition in Early Years Care Centres: Barriers and Facilitators". Journal of Childhood Studies 36, nr 1 (30.03.2010): 26–30. http://dx.doi.org/10.18357/jcs.v36i1.15136.
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Physical activity and good nutrition are key components of healthy living and reduce the risk of developing chronic diseases. Current research indicates that young Canadian children are not active enough for healthy growth and development (Temple et al., 2009). In addition their diets are lacking in fruits and vegetables, and excessively high in processed foods. Parents play a key role in establishing healthy behaviours; however early years professionals also have a strong influence, as many young children spend a large portion of their day in child care centres. This study aimed to use an ecological framework to identify specific factors (facilitators and barriers) that professionals in urban child care centres faced when promoting physical activity and nutrition. Seven urban child care centre professionals participated in one on one semi-structured interviews, with questions developed around McLeroy’s (1988) ecological model. Reported acilitators and barriers were categorized using the ecological model at individual level (i.e., intrapersonal) or social environmental (interpersonal, institutional, community, and policy) level. The classification of factors into distinct categories was important, as this information can aid in designing initiatives that target.
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García Fernández, Jerónimo, i Francisco Pires Vega. "Fidelización de usuarios mayores en centros de fitness: Gestión de clientes por programas de actividad física (The Loyalty of older people in fitness centers: Managing customers for physical activity programs)". Retos, nr 17 (9.03.2015): 103–6. http://dx.doi.org/10.47197/retos.v0i17.34686.
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Los centros de fitness, son hoy en día lugares donde los socios realizan actividad física «controlada», donde mejoran su estado físico y mental, incluso en donde se socializan con otros socios de todas las edades. Estos centros, han sido normalmente gestionados por personas sin formación en la materia y con el único interés de tener socios, sin tener en cuenta la repercusión a largo plazo. Este interés, sumado a problemas de gestión del centro, y a problemas personales de los socios, ha propiciado que existan altas tasas de deserción en este tipo de centros indoor, con la consecuente elevación de los gastos en marketing, no obteniendo así, una rentabilidad sostenible. Proponemos, un programa de actividad física con el que se podría mejorar estas tasas de fidelización, siendo el punto central de la gestión de los centros de hoy en día, la satisfacción y la lealtad a los centros de fitness.Palabra clave: Fidelización, Mayores, Centros de Fitness, Programa de Actividad física por objetivos.Abstract: The fitness centers are now places where partners perform «controlled» physical activity, which improves their physical and mental state, and where they socialize with other partners of all ages. These centers have been typically managed by people without training in this subject and with the only interest of obtaining partners without taking into account the long-term impact. This problem, together with management problems of the center and personal problems of the members, have meant that there are high desertion rates in this type of indoor facilities, with the consequent increase in expenditure on marketing and a non-sustainable profitability. We propose a program of physical activity that could improve the rate of loyalty, being the central point of management of sports centers today, the satisfaction and loyalty to the fitness centers.Key words: Loyalty, Senior, Fitness Centres, Physical Activity Programs Through Objectives.
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TITTLER, ROBERT. "Early Stuart Chester as a centre for regional portraiture". Urban History 41, nr 1 (29.07.2013): 3–21. http://dx.doi.org/10.1017/s096392681300031x.
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ABSTRACT:Scholarship on provincial towns and cities has thus far overlooked their role as centres of painting in the early modern era, leaving the false impression that painting, and art itself, remained the preserve of London. Chester proves a vibrant centre for such activities in the era 1590–1640. This article shows how and why the distinctive characteristics of Chester and its wider hinterland encouraged and shaped its production of portraiture. It also places Chester in the wider context of painting activity in other such provincial centres.
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Mantey, Dorota. "Local centres in post-socialist suburbs: Redefined concept and retrofitting perspectives". Moravian Geographical Reports 30, nr 3 (1.09.2022): 192–210. http://dx.doi.org/10.2478/mgr-2022-0013.
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Abstract Chaotically developed post-socialist suburbs need retrofitting by providing residents with a local central space. This research aims at developing a typology of suburban local centres, describing the most common central spaces according to adopted criteria, as well as identifying which type of local centre has the most potential to be perceived as such by suburbanites and how suburban municipalities plan central spaces. The research was conducted in six institutional Warsaw suburbs representing the most common types of local centres of a neighbourhood catchment area. The research has shown that spatial criteria differentiate local centres more than social criteria. Concentric layouts attract different non-residential functions more effectively than linear ones. When recognising some spaces as central, the legibility of the broader spatial arrangement and the presence of key objects with centre-forming functions seems to be important. Factors that distort such recognition include the excessive dispersion of buildings, shops, and service points; peripheral or random location of the main activity node; poorly designed and equipped central spaces; and the proximity to large-scale shopping centres and recreational areas/objects. When looking for a model of retrofitting post-socialist suburbs through strengthening neighbourhood centres, it is worth recalling the concept of the so-called “third places”.
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PRUDÊNCIO, Miguel, Robert R. EADY i Gary SAWERS. "Catalytic and spectroscopic analysis of blue copper-containing nitrite reductase mutants altered in the environment of the type 2 copper centre: implications for substrate interaction". Biochemical Journal 353, nr 2 (8.01.2001): 259–66. http://dx.doi.org/10.1042/bj3530259.
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The blue dissimilatory nitrite reductase (NiR) from Alcaligenes xylosoxidans is a trimer containing two types of Cu centre, three type 1 electron transfer centres and three type 2 centres. The latter have been implicated in the binding and reduction of nitrite. The Cu ion of the type 2 centre of the oxidized enzyme is ligated by three His residues, and additionally has a co-ordinated water molecule that is also hydrogen-bonded to the carboxyl of Asp92 [Dodd, Van Beeumen, Eady and Hasnain (1998), J. Mol. Biol. 282, 369Ő382]. Two mutations of this residue have been made, one to a glutamic acid residue and a second to an asparagine residue; the effects of both mutations on the spectroscopic and catalytic properties of the enzyme have been analysed. EPR spectroscopy revealed that both mutants retained intact type 1 Cu centres with g‖ = 2.12 (A‖ = 0mT) and g⊥ = 2.30 (A⊥ = 6.4mT), which was consistent with their blue colour, but differed in their activities and in the spectroscopic properties of the type 2 centres. The D92E mutant had an altered geometry of its type 2 centre such that nitrite was no longer capable of binding to elicit changes in the EPR parameters of this centre. Accordingly, this mutation resulted in a form of NiR that had very low enzyme activity with the artificial electron donors reduced Methyl Viologen and sodium dithionite. As isolated, the EPR spectrum of the Asp92 → Asn (D92N) mutant showed no characteristic type 2hyperfine lines. However, oxidation with iridium hexachloride partly restored a type 2 EPR signal, suggesting that type 2 copper is present in the enzyme but in a reduced, EPR-silent form. Like the Asp92 → Glu mutant, D92N had very low enzyme activities with either Methyl Viologen or dithionite. Remarkably, when the physiological electron donor reduced azurin I was used, both mutant proteins exhibited restoration of enzyme activity. The degree of restoration differed for the two mutants, with the D92N derivative exhibiting approx. 60% of the activity seen for the wild-type NiR. These findings suggest that on formation of an electron transfer complex with azurin, a conformational change in NiR occurs that returns the catalytic Cu centre to a functionally active state capable of binding and reducing nitrite.
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Crosetti, Anne-Sophie. "The ‘Converted Unbelievers’: Catholics in Family Planning in French-Speaking Belgium (1947–73)". Medical History 64, nr 2 (17.03.2020): 267–86. http://dx.doi.org/10.1017/mdh.2020.6.
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This paper looks at the journey of eleven counsellors in marital counselling centres in French-speaking Belgium, from the creation of the centres in 1953, to the 1970s, when contraception became legal, and abortion became a public issue. At the time of Humanae Vitae, groups of volunteers, working within Catholic organisations where counselling took place, began to structure their activity around Carl Rogers’s ethics of client-centred therapy, placing their religious ideology in a secondary position to focus on the problems experienced by the couples and women they were receiving in the centres. These were often challenges they were experiencing themselves in their own lives. The reiteration of the Catholic orthodox view on contraception through Humanae Vitae marked a gap between the counsellors and the Church. This contribution questions the identity-related tension of Catholics working in conjugal counselling centres and the type of commitments they made to both the conjugal centres and the Church in a moment where family planning was debated both in the Church and politically.
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Kozera, Agnieszka. "Investment Activity of Large Cities - Regional Centres in Poland". EUROPEAN RESEARCH STUDIES JOURNAL XXIV, Special Issue 1 (1.03.2021): 220–47. http://dx.doi.org/10.35808/ersj/2039.
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Gordon, M. "The mathematics of fountain design: a multiple-centres activity". Teaching Mathematics and its Applications 32, nr 1 (4.01.2013): 19–27. http://dx.doi.org/10.1093/teamat/hrs013.
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KADER, R., P. Middleton, O. Ahmad, R. Dart, J. McGuire, G. Sebepos-Rogers, J. Segal, E. Shakweh i M. Samaan. "P225 Using a standardised reporting proforma is associated with improved endoscopic assessment in UC". Journal of Crohn's and Colitis 14, Supplement_1 (styczeń 2020): S255. http://dx.doi.org/10.1093/ecco-jcc/jjz203.354.
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Abstract Background Repeated endoscopic assessments are an essential part of ulcerative colitis (UC) disease management and current guidelines recommend the use of an endoscopic activity score, either the endoscopic Mayo score or Ulcerative Colitis Endoscopic Index of Severity (UCEIS) as treatment targets. These indices have prognostic value, with endoscopic healing associated with favourable short- and long-term outcomes. This multi-centre study aimed to assess the frequency of using endoscopic disease activity scores in UC patients undergoing lower GI endoscopy. Methods Lower GI endoscopy reports from patients with UC were retrospectively reviewed from 7 sites in London between April and October 2018. Endoscopy reports were assessed based on the BRIDGe endoscopic reporting criteria including the use of Mayo or UCEIS score. The comparison was made between site factors (specialist IBD centres/non-specialist centres, use of reporting proforma), endoscopist speciality (gastroenterology, surgery or nurse endoscopist), level of training (consultant, registrar or nurse endoscopist) and interest in IBD. Chi-squared was used to compare groups. Results 899 lower GI endoscopy reports were reviewed. Mayo or UCEIS was used in 51% of cases (453/899). The use of endoscopic scores were significantly higher in gastroenterologists than in surgeons and nurse endoscopists respectively (401/762 (53%) vs. 22/54 (41%) vs. 30/83 (36%)), and higher in registrar trainees than consultants and nurse endoscopists (175/251 (70%) vs. 248/565 (44%) vs. 30/83 (36%)) and in those with a specialist interest in IBD compared with those without (237/409 (58%) vs. 216/490 (44%), p < 0.0001). The use of endoscopic scores was more frequent in specialist IBD centres than in non-specialist centres (417/728 (58%) vs. 36/172 (21%), p < 0.001). One centre used a reporting proforma which was associated with a significantly higher frequency of score use compared with centres without a proforma (202/260 (78%) vs. 251/639 (39%), p < 0.0001). Conclusion Reporting of endoscopic disease activity using a standardised scoring system occurs in only half of cases from this large multi-centre cohort. Frequency of use is higher in specialist IBD centres and when performed by gastroenterology specialists. Endoscopy reports from a site that used a standardised reporting proforma were significantly more likely to include an endoscopic index as well as a range of other reporting items. This suggests, at least in part, that endoscopy reporting may be optimised by the introduction of a proforma. Integration of a standardised proforma into reporting software would target all endoscopists performing UC endoscopies regardless of speciality, site or IBD interest.
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Magun, Sunder. "The Placement Activity on the Canadian Employment Agency". Relations industrielles 38, nr 1 (12.04.2005): 72–94. http://dx.doi.org/10.7202/029328ar.
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Clavel San Emeterio, Iván, Jorge García-Unanue, Eliseo Iglesias-Soler, Leonor Gallardo i José Luis Felipe. "Drop out prediction in sport centres. Definition of models and reproducibility (Predicción de bajas de clients en centros deportivos. Definición de modelos y reproducibilidad)". Retos, nr 37 (24.07.2019): 54–61. http://dx.doi.org/10.47197/retos.v37i37.71423.
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Abstract. Purpose: One of the main problems detected in the sport centre field is abandonment of physical activity by members. The aim of this estudy is to evaluate the reproducibility of predictive models of abandonment in sports centres, based on information collected through access control and the Customer Relationship Management system. Method: Monthly data corresponding to the actual behaviour of of two sport centres in Spain were recorded over the course of one year (12,545 members). Based on these variables, two predictive models were designed using the absence or permanence in the centre as an independent variable. Subsequently, the regression formula obtained was applied on all members of the same sports centres a year later (12,986 members), checking the effectiveness and reproducibility of the model. Results:. Logistic regression models based on customer historical behaviour were useful to predict abandonment. The effectiveness of the models was around 70% a year after. Conclusions: The segmentation of users based on the likelihood of drop out and the identification of behaviour variables that predict such drop out and the confirmation of the effectiveness of the predictive model, can help to optimize the design of loyalty strategies to prevent the abandonment in sport centres.Resumen. Objetivo: El abandono de la práctica deportiva por parte de clientes en centros deportivos es uno de los principals problemas en el sector. El objetivo de este estudio es evaluar la reproducibilidad de modelos predictivo de abandono en centros deportivos, basados en información recogida a través del control de accesos y el sistema Customer Relationship Management. Método: Se recopiló comportamientos mensuales de los clientes de dos centros deportivos en España durante un año (12,545 members). En base a dichas variables se diseñaron dos modelos predictivos utilizando la baja o permanencia en el centro como variable independiente. Posteriormente, se aplicó la formula de regression obtenida sobre todos los miembros de los mismos centros deportivos un año después (12,986 members), comprobando la efectividad y reproducibilidad del modelo. Resultados: Las estimaciones de regression logística fueron útiles para predecir el abandon en los centros deportivos. Además, reproduciendo el mismo modelos en una muestra diferente se consiguió aproximadamente un 70% de efectividad. Conclusiones: La segmentación de usuarios en base a la probabilidad de baja y la identificación de variables predictivas de dicha baja pueden optimizar el diseño de estrategias de prevención de abanadono en centros deportivos.
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Enoch, Marcus, Fredrik Monsuur, Garyfalia Palaiologou, Mohammed A. Quddus, Fiona Ellis-Chadwick, Craig Morton i Rod Rayner. "When COVID-19 came to town: Measuring the impact of the coronavirus pandemic on footfall on six high streets in England". Environment and Planning B: Urban Analytics and City Science 49, nr 3 (22.10.2021): 1091–111. http://dx.doi.org/10.1177/23998083211048497.
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Town centres in the economically developed world have struggled in recent years to attract sufficient visitors to remain economically sustainable. However, decline has not been uniform, and there is considerable variation in how different town centres have coped with these challenges. The arrival of the coronavirus (COVID-19) pandemic public health emergency in early 2020 has provided an additional reason for people to avoid urban centres for a sustained period. This paper investigates the impact of coronavirus on footfall in six town centres in England that exhibit different characteristics. It presents individual time series intervention model results based on data collected from Wi-fi footfall monitoring equipment and secondary sources over a 2-year period to understand the significance of the pandemic on different types of town centre environment. The data show that footfall levels fell by 57%–75% as a result of the lockdown applied in March 2020 and have subsequently recovered at different rates as the restrictions have been lifted. The results indicate that the smaller centres modelled have tended to be less impacted by the pandemic, with one possible explanation being that they are much less dependent on serving longer-distance commuters and on visitors making much more discretionary trips from further afield. It also suggests that recovery might take longer than previously thought. Overall, this is the first paper to study the interplay between footfall and resilience (as opposed to vitality) within the town centre context and to provide detailed observations on the impact of the first wave of coronavirus on town centres’ activity.
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Gudžinskienė, Vida, Rita Raudeliūnaitė i Rokas Uscila. "The Possibilities of Implementation of the Rights of the Child in Children’s Day Care Centres". Pedagogika 121, nr 1 (22.04.2016): 209–24. http://dx.doi.org/10.15823/p.2016.15.
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As economic and cultural changes proliferate in our society, there is an increasing number of families the functioning of which disrupted – they are called social risk families. Social risk families are dominated by such negative factors as alcohol consumption, violence, negligence, failure to comply with societal norms, which are observed by growing up children every day. Gradually children growing up in social risk families become socially injured and need exceptional assistance. In order to assist socially injured children children’s day care centres are established, one of the functions of which is to implement children’s rights. The objective of the study: to theoretically and empirically validate the possibilities of children’s day care centres to implement children’s rights. The subject of the study – the possibilities of children’s rights which are implemented in children’s day care centres. The methods of the study: theoretical methods – the analysis of scientific literature, documents. Empirical methods – a questionnaire survey (instrument – questionnaire), which was aimed at collecting information on the implementation of socially injured children’s rights attending children’s day centres. 255 children, who attend day centres in rural areas, participated in the study. The age limit of children is not less than 14 years and not more than 18 years and parents of whom gave permission that their child could participate in the study. Such children’s age span was chosen, taking into consideration the fact that the children of such age are sufficiently mature and able to adequately express their opinion (the United Nations Convention on the Rights of the Child (1989), G. M. Biegel (2009). The statistical methods of data analysis: descriptive statistics (the analysis of a frequency distribution), Spearman’s correlation coefficient.
The results of the study. The documents regulating the activity of children’s day care centres and the educational, socio-cultural activities, which are performed in the centres, and the material assistance, which is provided there, create the preconditions for the implementation of socially injured children’s rights. The empirical study on the implementation of children’s rights in children’s day care centres established that: a favourable psychological atmosphere which is created by the employees in day care centres and the carried out activities create conditions to implement the rights of the majority of socially injured children (a right to be not discriminated, free, healthy, respected, supervised, a right to a cultural activity, leisure and rest, education, (self-) development, a right to express their opinion, be provided for and supervised); the implementation of children’s rights in children’s day care centres is aggravated by a considerable distance between the children’s place of residence and a day care centre. Consequently, part of children stay in a day care centre briefly, they give little or no time for doing homework, participate in sociocultural activities rarely. Part of children have their rights to education and (self-)development, thoughtful and comprehensive leisure partly ensured; more than half of the investigators do not receive material assistance in day care centres. Children’s day care centres only partly ensure a children’s right to be provided for and healthy. It is appropriate to organise the ride of children in children’s day centres, which are in rural areas, in such a way that conditions would be created to all the children, who attend a day care centre, to participate both in educational and sociocultural activities.
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MARAKAKIS, Ioannis, Angelos SIOLAS i Thomas N. CHATZICHRISTOS. "Town Centricity Model – Delimiting the center of Athens, Greece". European Journal of Geography 13, nr 2 (12.04.2022): 44–59. http://dx.doi.org/10.48088/ejg.i.mar.13.2.44.59.
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Town centres have been analysed by researchers according to the specific parameters of their studies such as concentration cores of economic activity or on the basis of social and demographic attributes, diversity of land uses, etc. However, it is the synthesis of all centre’s characteristics that most completely define it. Moreover, in Greece, there is no sufficient statistical information available concerning town centres and it is necessary to create such data in order to improve their monitoring, control and planning. In order to apply this information, the boundary of town centre has to be set. This paper envisages in the definition of a town centre, the creation of a “Town Centricity Model” and the development and implementation of a consistent methodology resulting to its delimitation. After survey, analysis and evaluation of characteristics serving as centrality estimators, the most critical are deployed and the methodology is implemented. The latter concerns the design and creation of a geodatabase in a Geographic Information System (GIS) with features and attributes set to the spatial reference unit of a building block. The use of both vector and raster spatial analyses are addressed, the most representative qualitative methods are surveyed and weighting factors with the use of Delphi method are assigned. The pilot study of the aforementioned methodology is implemented in a case study area located in the municipality of Athens in Greece, resulting to the delimitation of its centre. The results are presented and ongoing future research is further discussed.
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Tucker, Patricia, Molly Driediger, Leigh M. Vanderloo, Shauna M. Burke, Jennifer D. Irwin, Andrew M. Johnson, Jacob Shelley i Brian W. Timmons. "Exploring the Feasibility and Effectiveness of a Childcare PhysicaL ActivitY (PLAY) Policy: Rationale and Protocol for a Pilot, Cluster-Randomized Controlled Trial". International Journal of Environmental Research and Public Health 16, nr 22 (11.11.2019): 4400. http://dx.doi.org/10.3390/ijerph16224400.
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Background: Young children are prone to low levels of physical activity in childcare. This environment, inclusive of equipment, policies, and staff, has been identified as influencing young children’s activity behaviours. To date, no study has examined the feasibility and effectiveness of such policies in Canadian childcare centres, while the provision of physical activity policies in other countries has shown some promise for improving the activity levels of young children. As such, the primary objective of the Childcare PhysicaL ActivitY (PLAY) Policy study is to examine the feasibility of an evidence-based, stakeholder-informed, written physical activity and sedentary time policy for centre-based childcare (i.e., at the institutional level). The secondary objectives are to examine the impact of policy implementation on the physical activity levels and sedentary time of young children, subsequent environmental changes in childcare centres, and childcare providers’ self-efficacy to implement a physical activity policy. This study will examine both policy implementation and individual (behavioural) outcomes. Methods/Design: The Childcare PLAY Policy study, a pilot, cluster-randomized controlled trial, involves the random allocation of childcare centres to either the experimental (n = 4) or control (n = 4) group. Childcare centres in the experimental group will adopt a written physical activity policy for eight weeks (at which time they will be asked to stop enforcing the policy). Physical activity levels and sedentary time in childcare will be assessed via ActiGraph™ accelerometers with measurements at baseline (i.e., week 0), mid-intervention (i.e., week 4), immediately post-intervention (i.e., week 9), and at six-month follow-up. Policy implementation and feasibility will be assessed using surveys and interviews with childcare staff. The Environment and Policy Assessment and Observation Self-Report tool will capture potential changes to the childcare setting. Finally, childcare providers’ self-efficacy will be captured via a study-specific questionnaire. A nested evaluation of the impact of policy implementation on young children’s physical activity levels will be completed. A linear mixed effects models will be used to assess intervention effects on the primary and secondary outcomes. Descriptive statistics and thematic analysis will be employed to assess the feasibility of policy implementation. Discussion: The Childcare PLAY Policy study aims to address the low levels of physical activity and high sedentary time observed in childcare centres by providing direction to childcare staff via a written set of evidence-informed standards to encourage young children’s activity and reduce sedentary time. The findings of this work will highlight specific aspects of the policy that worked and will inform modifications that may be needed to enhance scalability. Policy-based approaches to increasing physical activity affordances in childcare may inform future regulations and programming within this environment.
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Goodman, Robin, i Matthew Coote. "Sustainable Urban Form and the Shopping Centre: An Investigation of Activity Centres in Melbourne's Growth Areas". Urban Policy and Research 25, nr 1 (marzec 2007): 39–61. http://dx.doi.org/10.1080/08111140701225578.
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Mamaev, A. V., L. D. Samusenko i M. V. Barkova. "LOCATION, ELECTROPHYSIOLOGICAL ACTIVITY AND STRUCTURE OF SHEEP BIOLOGICALLY ACTIVE CENTRES". VESTNIK OF THE BASHKIR STATE AGRARIAN UNIVERSITY 40, nr 4 (13.12.2016): 61–68. http://dx.doi.org/10.31563/1684-7628-2016-40-4-61-68.
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Yamashita, Hiroki, Tadashi Fujii i Satoru Itoh. "The development of diverse suburban activity centres in Melbourne, Australia". Applied GIS 2, nr 2 (styczeń 2006): 9.1–9.26. http://dx.doi.org/10.2104/ag060009.
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Pettipher, Charlotte, i Jim Mansell. "ENGAGEMENT IN MEANINGFUL ACTIVITY IN DAY CENTRES: AN EXPLORATORY STUDY". Mental Handicap Research 6, nr 3 (25.03.2010): 263–74. http://dx.doi.org/10.1111/j.1468-3148.1993.tb00057.x.
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Bowman, Ann Marie, i Catherine Foster. "Physical Activity Advisement Practices in Diabetes Education Centres across Canada". Canadian Journal of Diabetes 31, nr 2 (styczeń 2007): 131–39. http://dx.doi.org/10.1016/s1499-2671(07)12008-6.
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Sullivan, R., G. Lewison i A. D. Purushotham. "An analysis of research activity in major UK cancer centres". European Journal of Cancer 47, nr 4 (marzec 2011): 536–44. http://dx.doi.org/10.1016/j.ejca.2010.10.015.
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Brooker, D., R. Dröes, R. Chattat, E. Farina, J. Rymaszewska, F. Meiland, S. Evans i C. Henderson. "ENABLING PARTICIPATION IN SOCIAL ACTIVITY: THE MEETING CENTRES SUPPORT PROGRAMME". Innovation in Aging 2, suppl_1 (1.11.2018): 584. http://dx.doi.org/10.1093/geroni/igy023.2166.
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Wolfenden, Luke, Melinda Neve, Louise Farrell, Christophe Lecathelinais, Colin Bell, Andrew Milat, John Wiggers i Rachel Sutherland. "Physical activity policies and practices of childcare centres in Australia". Journal of Paediatrics and Child Health 47, nr 3 (marzec 2011): 73–76. http://dx.doi.org/10.1111/j.1440-1754.2010.01738.x.
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McDougall, Andrew, i Lucy Groenhart. "Recent experiences in facilitating urban change in Victorian activity centres". Australian Planner 44, nr 1 (marzec 2007): 34–40. http://dx.doi.org/10.1080/07293682.2007.9982543.
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Kosovska, A. "PROFESSIONAL ACTIVITY OF A CORRECTIONAL TEACHER AT THE INSTITUTIONS FOR CHILDREN WITH SPECIAL EDUCATIONAL NEEDS". Zhytomyr Ivan Franko state university journal. Рedagogical sciences, nr 1(108) (7.06.2022): 164–89. http://dx.doi.org/10.35433/pedagogy.1(108).2022.164-189.
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The article presents the concept of correctional (special education) teacher based on current legislation and studies the network of institutions for children with special educational needs, which are subordinated to various ministers of Ukraine, in particular: the Ministry of Education and Science of Ukraine (MES); the Ministry of Social Policy of Ukraine; the Ministry of Health of Ukraine (MoH). Considering the purpose and specifics of the institutions that provide education and upbringing of children with special educational needs and in their activities are subordinated to various ministers of Ukraine, the essence of the professional activity of a correctional teacher in each of the relevant institutions is highlighted, in particular: in the pre-school education institutions of compensatory and combined types, in the special school; in the educational and rehabilitation centre, in the inclusive education institutions, in the inclusive resource centres, which are subordinated to the Ministry of Education and Science of Ukraine; in the orphanage, in the comprehensive rehabilitation centres, which are subordinated to the Ministry of Social Policy of Ukraine; in the childcare home and in the rehabilitation institutions, which are subordinated to the Ministry of Health of Ukraine.
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Li, Jia, Patrizio Mazzone, Lisa W. M. Leung, Weiqian Lin, Giuseppe D’Angelo, Jun Ma, Jin Li i in. "Electrophysiology in the time of coronavirus: coping with the great wave". EP Europace 22, nr 12 (30.09.2020): 1841–47. http://dx.doi.org/10.1093/europace/euaa185.
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Abstract Aims To chart the effect of the COVID-19 pandemic on the activity of interventional electrophysiology services in affected regions. Methods and results We reviewed the electrophysiology laboratory records in three affected cities: Wenzhou in China, Milan in Italy, and London in the UK. We inspected catheter lab records and interviewed electrophysiologists in each centre to gather information on the impact of the pandemic on working patterns and on the health of staff members and patients. There was a striking decline in interventional electrophysiology activity in each of the centres. The decline occurred within a week of the recognition of widespread community transmission of the virus in each region and shows a striking correlation with the national figures for new diagnoses of COVID-19 in each case. During the period of restriction, workflow dropped to <5% of normal, consisting of emergency cases only. In two of three centres, electrophysiologists were redeployed to perform emergency work outside electrophysiology. Among the centres studied, only Wenzhou has seen a recovery from the restrictions in activity. Following an intense nationwide programme of public health interventions, local transmission of COVID-19 ceased to be detectable after 18 February allowing the electrophysiology service to resume with a strict testing regime for all patients. Conclusion Interventional electrophysiology is vulnerable to closure in times of great social difficulty including the COVID-19 pandemic. Intense public health intervention can permit suppression of local disease transmission allowing resumption of some normal activity with stringent precautions.
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Wright, C. A., B. Hilder i M. E. Schneider-Kolsky. "Meeting the research agenda in Australian radiation therapy: the current picture". Journal of Radiotherapy in Practice 8, nr 2 (czerwiec 2009): 67–77. http://dx.doi.org/10.1017/s1460396908006596.
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AbstractIn recent years the role of the radiation therapist (RT) has increasingly evolved. In Australia, one of the major developments has been the transition from practice which was rarely based on scientific evidence, to the profession today which engages in and incorporates research into everyday practice. The aim of this article is to provide an insight into the current status of Australian radiation therapy research. In order to present a national overview, a survey relating to research activity was e-mailed to all (48) clinical centres in Australia. Thirty-six out of the 48 centres responded, representing 13 private and 23 public centres. The results demonstrated that a research culture is beginning to be established and that there are challenges associated with implementing research. The role of universities in facilitating the development of research skills was considered important with an increasing number of practitioners undertaking higher research degrees. Overall, research activity in the Australian radiation therapy community is becoming more prevalent. If the profession is to continue to strengthen its research profile the professional body and universities need to continue providing academic and funding support. Greater focus on multidisciplinary collaboration is needed with direct involvement of RTs in multi-centre studies.
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Haglund, Björn, i Louise Peterson. "Why use board games in leisure-time centres? Prominent staff discourses and described subject positions when playing with children". International Journal for Research on Extended Education 5, nr 2-2017 (30.07.2018): 188–206. http://dx.doi.org/10.3224/ijree.v5i2.06.
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Board games are traditionally seen as an important Swedish leisure-time centre activity, but research regarding this activity is sparse. This study aims to fill part of that void through a web survey directed to members in a closed Facebook group focusing on leisure-time centres. Fifty-five informants’ answers were analysed using critical discourse analysis to find why staff at leisure-time centres use board games. The article also discusses the subject positions the staff use when playing board games with the children. The results reveal four prominent discourses, which were termed: supporting social structure, learning social competence, substituting digital games, and learning cognitive abilities. The results also reveal three subject positions while playing board games: developer, supervising judge, and participant. The informants’ discourses regarding their reasons for using board games and the positions the staff settled into while playing board games drew mostly from a social pedagogical arena. However, features that emphasize traditional school related content are also evident.
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Sader, Helio S., Paul R. Rhomberg, Leonard R. Duncan, Hans H. Locher, Glenn E. Dale i Robert K. Flamm. "Antimicrobial activity of POL7306 tested against clinical isolates of Gram-negative bacteria collected worldwide". Journal of Antimicrobial Chemotherapy 75, nr 6 (22.02.2020): 1518–24. http://dx.doi.org/10.1093/jac/dkaa020.
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Abstract Background POL7306 belongs to a new class of peptidomimetic outer-membrane-protein-targeting antibiotics with a novel mechanism of action. POL7306 is in development for the treatment of infections caused by antimicrobial-resistant Gram-negative bacteria and has demonstrated low cytotoxicity and nephrotoxicity. Methods A total of 891 isolates were collected by the SENTRY Antimicrobial Surveillance Program from 134 medical centres in Europe (n = 424; 41 centres in 18 nations), the USA (n = 411 isolates from 67 centres), the Asia-Pacific region (n = 24; 15 centres in 6 nations) and Latin America (n = 32; 11 centres in 9 nations) and included 558 Enterobacterales, 310 non-fermenters and 23 fastidious organisms. Susceptibility testing was performed using the reference broth microdilution method and the medium was supplemented with 0.002% polysorbate-80 for testing POL7306. Resistant subsets were characterized by WGS. Results POL7306 demonstrated potent in vitro activity against Enterobacterales [including carbapenem-resistant (MIC50/90, 0.06/0.25 mg/L), ESBL-producing (MIC50/90, 0.06/0.12 mg/L), KPC-producing (MIC50/90, 0.12/0.25 mg/L), MBL-producing (MIC50/90, 0.06/0.25 mg/L), colistin-non-susceptible, mcr-negative (MIC50/90, 0.5/2 mg/L) and mcr-positive (MIC50/90, 0.12/0.25 mg/L) Enterobacterales], Pseudomonas aeruginosa (MIC50/90, 0.25/0.25 mg/L), Acinetobacter baumannii (MIC50/90, 0.06/0.12 mg/L) and Stenotrophomonas maltophilia (MIC50/90, 0.06/0.25 mg/L). Conclusions POL7306 demonstrated potent activity against a large collection of Gram-negative organisms collected worldwide that included colistin-resistant, XDR and ESBL- and carbapenemase-producing isolates for which there are currently limited treatment options.
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Thompson, S. G., F. Duckert, F. Haverkate i J. M. Thomson. "The Measurement of Haemostatic Factors in 16 European Laboratories: Quality Assessment for the Multicentre ECAT Angina Pectoris Study". Thrombosis and Haemostasis 61, nr 02 (1989): 301–6. http://dx.doi.org/10.1055/s-0038-1646581.
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SummaryAs part of a European multicentre prospective study involving the measurement of a number of haemostatic factors, a quality assessment (QA) scheme was organized. This paper describes the preparation, design and results of the first Qa exercise, involving 16 European laboratories and 10 haemostatic assays. The design allowed the investigation, for each assay, of the variability between duplicates and the variability between days within each centre, and of the agreement between centres. A graphical presentation of each centre’s performance in comparison to that of others was adopted, which preserved the confidentiality of each centre’s results. The factor VIII clotting activity assay (VIII: C) and the rocket immuno-electrophoresis assays of von Willebrand factor related antigen (vWF R:Ag), antithrombin III, protein C and histidine-rich glycoprotein showed the highest betweenduplicate and between-day coefficients of variation (CVs), whereas the clotting assays of activated partial thromboplastin time and fibrinogen had the lowest CVs. CVs for the enzymatic assays using synthetic substrates of antithrombin III, plasminogen and alpha-2-antiplasmin were between these extremes. The between-centre CVs were high for both the VIII:C and vWFR:Ag assays. The QA exercise showed that, in multicentre studies involving the measurement of haemostatic factors, it is feasible to undertake analysis locally at each centre.
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Harries, Iwan, Jonathan R. Weir-McCall, Michelle C. Williams, James Shambrook, Giles Roditi, Russel Bull, Gareth J. Morgan-Hughes, Edward D. Nicol i Alastair J. Moss. "CT imaging prior to transcatheter aortic valve implantation in the UK". Open Heart 7, nr 1 (kwiecień 2020): e001233. http://dx.doi.org/10.1136/openhrt-2019-001233.
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ObjectiveThis cross-sectional observational study sought to describe variations in CT in the context of transcatheter aortic valve implantation (CT-TAVI) as currently performed in the UK.Methods408 members of the British Society of Cardiovascular Imaging were invited to complete a 27-item online CT-TAVI survey.Results47 responses (12% response rate) were received from 40 cardiac centres, 23 (58%) of which performed TAVI on-site (TAVI centres). Only six respondents (13%) performed high-volume activity (>200 scans per year) compared with 13 (28%) performing moderate (100–200 scans per year) and 27 (59%) performing low (0–99 scans per year) volume activity. Acquisition protocols varied (41% retrospective, 12% prospective with wide padding, 47% prospective with narrow padding), as did the phase of reporting (45% systolic, 37% diastolic, 11% both, 6% unreported). Median dose length product was 675 mGy.cm (IQR 477–954 mGy.cm). Compared with non-TAVI centres, TAVI centres were more likely to report minimum iliofemoral luminal diameter (n=25, 96% vs n=7, 58%, p=0.003) and optimal tube angulation for intervention (n=12, 46% vs n=1, 8%, p=0.02).ConclusionsThis national survey formally describes current CT-TAVI practice in the UK. High-volume activity was only present at one in seven cardiac CT centres. There is wide variation in scan acquisition, scan reporting and radiation dose exposure in cardiac CT centres.
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Nikolajsen, Helene, Louise Fleng Sandal, Carsten Bogh Juhl, Jens Troelsen i Birgit Juul-Kristensen. "Barriers to, and Facilitators of, Exercising in Fitness Centres among Adults with and without Physical Disabilities: A Scoping Review". International Journal of Environmental Research and Public Health 18, nr 14 (9.07.2021): 7341. http://dx.doi.org/10.3390/ijerph18147341.
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Fitness centres are an obvious arena for performing physical activity for the general population but representation of adults with physical disabilities (AwPD) is lacking. To increase possibilities for AwPD to exercise in fitness centres together with adults without physical disabilities (AwoPD), the aim of this study was to identify, synthesise, and compare barriers to, and facilitators of, exercising in fitness centres for each group. A scoping review was conducted and data extraction of the barriers and facilitators was performed independently by two researchers on six categories of contextual factors based on the framework of Di Blasi: (1) The fitness centre setting; (2) The fitness centre user characteristics; (3) The fitness instructor/staff characteristics; (4) The fitness centre user–instructor/management relationship; and (5) The fitness/exercise characteristics. An extra category, (6) Other relationships, was added. The PRISMA Extension for Scoping Reviews was used for reporting. Of the 102 included papers, only 26 (25%) of the papers were on AwPD, which focused mainly on physical barriers (category 1: inaccessible settings). In contrast, the remaining 76 papers involving AwoPD focused primarily on facilitators (category 2: motivational factors and exercising effects). In categories 3–6, the two groups had similar results, as both groups preferred skilled instructors, a welcoming and comfortable fitness centre environment, an ability to exercise at their preferred type and level, and good social connections. Since most data were based on AwoPD, more studies on actual experiences from AwPD are needed, to reveal the facilitators/motivational factors for fitness centre use.
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БАБУШКО, Світлана, i Людмила СОЛОВЕЙ. "Models of adult education centres in Ukraine". EUROPEAN HUMANITIES STUDIES: State and Society 1, nr I (23.03.2019): 4–17. http://dx.doi.org/10.38014/ehs-ss.2019.1-i.01.
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Non-formal adult education is dynamically developing in different forms. The article represents them in the example of Ukraine. Non-formal education was acknowledged only in 2017 in the Law of Ukraine “On Education”, though it had been provided in several forms before. Currently, the most popular form of non-formal adult education in Ukraine is the Centers for Adult Education. They are created on the initiative of public organizations in partnership with foreign adult education organizations, in particular DVV International. To analyze their profiles there were identified several criteria: relation to formal or nonformal education, initiators and organizers, target audience, providers of methodical and financial assistance, thematic directions of their activity. As a result of the analysis according to the identified criteria, the information from Internet resources on the activity of adult educational centres was systemized; their similar and different features in their organization form were distinguished and defined their models: university- and college-based, school-based; museum and library-based. In addition, the directions for the further scientific research in this field were outlined.
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Adams, Mark, Thomas M. Berger, Cristina Borradori-Tolsa, Myriam Bickle-Graz, Sebastian Grunt, Roland Gerull, Dirk Bassler i Giancarlo Natalucci. "Association between perinatal interventional activity and 2-year outcome of Swiss extremely preterm born infants: a population-based cohort study". BMJ Open 9, nr 3 (marzec 2019): e024560. http://dx.doi.org/10.1136/bmjopen-2018-024560.
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ObjectivesTo investigate if centre-specific levels of perinatal interventional activity were associated with neonatal and neurodevelopmental outcome at 2 years of age in two separately analysed cohorts of infants: cohort A born at 22–25 and cohort B born at 26–27 gestational weeks, respectively.DesignGeographically defined, retrospective cohort study.SettingAll nine level III perinatal centres (neonatal intensive care units and affiliated obstetrical services) in Switzerland.PatientsAll live-born infants in Switzerland in 2006–2013 below 28 gestational weeks, excluding infants with major congenital malformation.Outcome measuresOutcomes at 2 years corrected for prematurity were mortality, survival with any major neonatal morbidity and with severe-to-moderate neurodevelopmental impairment (NDI).ResultsCohort A associated birth in a centre with high perinatal activity with low mortality adjusted OR (aOR 0.22; 95% CI 0.16 to 0.32), while no association was observed with survival with major morbidity (aOR 0.74; 95% CI 0.46 to 1.19) and with NDI (aOR 0.97; 95% CI 0.46 to 2.02). Median age at death (8 vs 4 days) and length of stay (100 vs 73 days) were higher in high than in low activity centres. The results for cohort B mirrored those for cohort A.ConclusionsCentres with high perinatal activity in Switzerland have a significantly lower risk for mortality while having comparable outcomes among survivors. This confirms the results of other studies but in a geographically defined area applying a more restrictive approach to initiation of perinatal intensive care than previous studies. The study adds that infants up to 28 weeks benefited from a higher perinatal activity and why further research is required to better estimate the added burden on children who ultimately do not survive.